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J Vasc Surg Venous Lymphat Disord 2022 Aug 8. Epub 2022 Aug 8.

Department of Surgery, Icahn School of Medicine at Mount Sinai.

Objective: Many patients present with chronic proximal venous outflow obstruction (PVOO) and superficial venous insufficiency (SVI) at the time of iliac vein stenting. This study aimed to determine if there was a difference in outcomes for patients receiving an iliac vein stent based on whether these patients had SVI.

Methods: A registry of 553 patients who underwent iliac vein stent placement for chronic PVOO from 2011-2021 was retrospectively analyzed. Read More

Actas Dermosifiliogr 2022 Aug 8. Epub 2022 Aug 8.

Department of Vascular Medicine, Hospital Privado, Córdoba, Argentina.

Background And Aims: Few studies have evaluated the correlation between the severity of cutaneous manifestations of chronic venous disease (CVD) of the lower limbs measured by the Clinical, Etiologic, Anatomic and Pathophysiologic classification (CEAP) and the Venous Clinical Severity Score (VCSS) combined, its risk factors, and venous reflux determined by Doppler ultrasonography. The purpose of this study was to compare the clinical severity assessed by CEAP and VCSS with known risk factors for CVD and the severity of venous reflux.

Methods: A prospective study was carried out on 250 patients with CVD characterized as C2 to C6 according to the CEAP classification, who attended the departments of Dermatology and Vascular Medicine at the Hospital Privado Universitario de Córdoba from April 2013 to December 2014. Read More

Adv Ther 2022 Aug 11. Epub 2022 Aug 11.

Department of Surgery, Vascular Screening and Diagnostic Centre, University of Nicosia Medical School, Engomi, 2 Kyriacou Matsi Street, Ayios Dhometios, 2368, Nicosia, Cyprus.

The importance of chronic venous disease (CVD), as a cause of reduced quality of life and increased costs to healthcare systems, is expected to rise in parallel with population aging and the increasing prevalence of obesity. Venoactive drugs (VADs) are frequently used to treat the symptoms and signs of CVD. The most commonly used and widely studied VAD, micronised purified flavonoid fraction (MPFF), is effective at all stages of CVD, and has been shown to significantly reduce leg pain, leg heaviness and swelling, as well as ankle oedema and functional discomfort, in clinical trials. Read More

J Vasc Surg Venous Lymphat Disord 2022 Aug 5. Epub 2022 Aug 5.

Department of Surgery, Division of Vascular Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

Objective: Extremity venous aneurysms put patients at risk of pulmonary embolism (PE) and chronic venous insufficiency. Presently, due to the rarity of these aneurysms, no consensus for their treatment exists. The purpose of this study was to review the presentation, natural history, and contemporary management of extremity venous aneurysms. Read More

PLoS One 2022 8;17(8):e0272566. Epub 2022 Aug 8.

Thrombosis Expert Centre Maastricht and Laboratory for Clinical Thrombosis and Haemostasis, Maastricht, The Netherlands.

Background: Although compression therapy is well established for patients with deep venous thrombosis (DVT) and chronic venous disease (CVD), considerable variation exists in its organization in clinical practice which may impact patient outcomes. The current study aims to deepen our understanding of the main drivers of the complex care organization for compression therapy and to identify targets for improvement.

Methods: This realist evaluation includes a mixed-method design consisting of semi-structured interviews with patients and health care professionals involved in compression therapy (n = 30), stakeholder meetings (n = 2) and surveys (n = 114). Read More

Ultrasound 2022 Aug 17;30(3):236-245. Epub 2021 Oct 17.

Western Sydney Vascular, Westmead, Australia.

Objective: Chronic venous disease is a common vascular condition, affecting up to 60% of the population worldwide. In Australia and New Zealand, chronic venous insufficiency ultrasound examinations are primarily performed by sonographers. This research aimed to explore how ultrasound examinations are being performed, providing insights into current practices and recommendations for quality improvement. Read More

J Coll Physicians Surg Pak 2022 Aug;32(8):1009-1013

Department of Cardiovascular Surgery, Bahcelievler State Hospital, Istanbul, Turkey.

Objective: To evaluate the outcomes of radiofrequency ablation (RFA) therapy performed on patients with great saphenous vein insufficiency.

Study Design: Descriptive study.

Place And Duration Of Study: Bahcelievler State Hospital, Istanbul, Turkey, between January 2018 and May 2021 Methodology: A total of 709 patients (382 females, 327 males), who were treated with radiofrequency ablation (RFA) in the clinic, were included in the study. Read More

J Vasc Surg Venous Lymphat Disord 2022 Aug 2. Epub 2022 Aug 2.

Cardiovascular Medicine, Fukuoka Sanno Hospital.

Background: Venous stenting is increasingly used to manage femoro-ilio-caval venous outflow obstruction/stenosis due to postthrombotic syndrome (PTS). Although the safety, efficacy, and long-term patency of venous stents have been reported, re-interventions due to stent occlusion and in-stent restenosis (ISR) have also been reported. The mechanism of ISR and the in-stent neointimal growth after venous stenting remains unclear. Read More

Comput Math Methods Med 2022 26;2022:2718314. Epub 2022 Jul 26.

Department of General Surgery, Haining People's Hospital, Zhejiang Province, Haining, 314400 Zhejiang, China.

Purpose: This research is aimed at elucidating the clinical efficacy of balloon dilatation (BD) plus stent implantation for nonthrombotic iliac vein compression syndrome (NIVCS) combined with chronic venous insufficiency (CVI) in different compression positions.

Methods: Sixty-five NIVCS patients comorbid with CVI admitted between December 2015 and April 2020 were selected and assigned to two groups according to different iliac vein compression positions. Both groups of patients received iliac vein BD + stent implantation, with the difference lying in that the tip of the stent was inserted 0. Read More

Ann Vasc Surg 2022 Aug 1. Epub 2022 Aug 1.

Department of Vascular and Endovascular Surgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.

Objective: The current study aimed to evaluate the distance between the right common iliac artery (RCIA) and lumbar vertebra in asymptomatic patients in order to determine whether such distance was statistically correlated with the left common iliac vein (LCIV) diameter (LCIVD) and to investigate if both measures were related to demographic characteristics and anthropometric data, such as sex, age, height, and body mass index (BMI).

Methods: In this descriptive and uncontrolled anatomic study, data from high-definition computed tomography (CT) angiography images of living kidney donors without a medical history of chronic venous insufficiency or past deep vein thrombosis (DVT) were analyzed. The RCIA crossed over the LCIV in 311 individuals, who were then included in this study. Read More

Wiad Lek 2022 ;75(6):1540-1543

POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.

Objective: The aim: To analyze the occurrence of complications and evaluate the quality of life in patients who got less-invasive treatment methods using endovenous laser ablation of varicose veins of the lower extremities in the early and late postoperative periods.

Patients And Methods: Materials and methods: The study was conducted with the participation of 100 patients treated in 2019-2020 by one team of surgeons for varicose veins of the lower extremities with symptoms of chronic venous insufficiency C2-C4 (CEAP classification). Depending on the performance of endovenous surgical interventions, all patients were divided into two study groups. Read More

Int J Mol Sci 2022 Jul 19;23(14). Epub 2022 Jul 19.

Department of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland.

Chronic wounds are becoming an increasingly common clinical problem due to an aging population and an increased incidence of diabetes, atherosclerosis, and venous insufficiency, which are the conditions that impair and delay the healing process. Patients with diabetes constitute a group of subjects in whom the healing process is particularly prolonged regardless of its initial etiology. Circulatory dysfunction, both at the microvascular and macrovascular levels, is a leading factor in delaying or precluding wound healing in diabetes. Read More

Biomolecules 2022 06 28;12(7). Epub 2022 Jun 28.

Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Department of Surgical, Medical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.

Chronic venous disease is a condition globally widespread, resulting in a disabling pathological disorder. The CD4 + Th17+ (Cluster Differentiation 4) lymphocytes represent a regulative factor for innate immunity related to the development of complex diseases. Recently, these mechanisms have been associated with vascular disease. Read More

Eur J Vasc Endovasc Surg 2022 Jul 21. Epub 2022 Jul 21.

The RANE Center for Venous and Lymphatic Diseases, Jackson, MS 39216. Electronic address:

J Vasc Surg Venous Lymphat Disord 2022 Jul 21. Epub 2022 Jul 21.

Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI. Electronic address:

Objective: Phlebectomy of large voluminous varicose veins comes with a risk of substantial blood loss. The purpose of this study is to investigate outcomes associated with use of an adjunct tourniquet during varicose vein surgery of complex and large truncular varicosities.

Methods: Registry data prospectively captured anatomic and outcome data for patients who presented with clinical classification C2 or more severe venous disease from December 2014 to December 2021. Read More

J Vasc Surg Venous Lymphat Disord 2022 Jul 14. Epub 2022 Jul 14.

MedStar Washington Hospital Center, Washington D.C., DC, USA.

Objectives: Chronic venous insufficiency (CVI) affects up to 40% of the US population and thus, intervention for symptomatic venous disease comprises a large portion of many vascular practices. Treatment of chronic superficial venous insufficiency has evolved from open surgical treatment to minimally invasive endovenous closure, which includes both thermal and non-thermal techniques. Thrombotic complications of thermal ablation are well reported with an overall complication rate of <2%. Read More

Phlebology 2022 Jul 14:2683555221114545. Epub 2022 Jul 14.

Department of Surgery, 75231Bharati Vidyapeeth Deemed University, Sangli, India.

Objective: To evaluate the incidence of anomalies in the superficial venous system in lower limb.

Method: Triplex ultrasonography in clinically suspected cases of acute or chronic venous disease or congenital malformation was performed on 3189 lower limbs in 2000 patients (bilateral in 1189 and unilateral in 811) from Jan 2020 to Dec 2020.

Result: (1) Anomalies of great saphenous vein were observed in 496 cases (15. Read More

Ann Vasc Surg 2022 Jul 8. Epub 2022 Jul 8.

Department of Vascular Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi, China. Electronic address:

Background: Diet is fundamental to maintaining and improving human health. There is ample evidence identifying the beneficial and/or harmful effects of diet on noncommunicable diseases such as obesity, diabetes mellitus, and cardiovascular disease. However, the associations of the diet to chronic venous disease has not been fully described. Read More

Wounds 2022 02;34(2):E13-E16

Aster Aadhar Hospital, Shastri Nagar, Kolhapur, Maharashtra, India.

Introduction: Nonhealing ulcers are difficult to manage because they deviate from the normal wound healing process. The standard treatment with saline dressings is not efficient in treating patients with such wounds; advanced wound care dressings are needed. Chitosan-based advanced wound dressings are gaining popularity because of their unique characteristics, such as absorbency, conformability, and pain alleviation at the wound bed. Read More

Wounds 2022 02;34(2):E10-E12

Ospedale Civile di Livorno, Livorno, Italy.

Introduction: Due to venous insufficiency, a vascular ulcer frequently occurs with the progression of stasis dermatitis. Achromic melanoma, a rare form of pigmentless melanoma frequently located on the sole of the foot, is often and easily confused with a typical wound. Diagnosis of ulcerated achromic melanoma is thus often delayed and associated with a poor prognosis. Read More

J Wound Care 2022 Jul;31(7):548-558

Triticum Exploitatie BV, Sleperweg 44, 6222NK Maastricht, the Netherlands.

Objective: Hard-to-heal wounds can be caused by persistent infections or an excess of inflammatory cytokines, proteases and oxidants, and can severely impact the quality of life (QoL) of patients. Due to the paucity of effective treatments and increased resistance to antibiotics, new and improved therapies are required to resolve infections and to simultaneously enhance the healing trajectory. Medical grade honey (MGH) may be a novel and effective treatment approach. Read More

J Hypertens 2022 08 5;40(8):1530-1536. Epub 2022 Jul 5.

University Milano-Bicocca, Milan, Italy.

Aim: The current study was designed at assessing whether the sympathetic cardiovascular drive (SNS) is differently activated in chronic kidney disease (CKD) patients displaying less or more elevated resting heart rate (HR) values. It was also designed at determining at which HR cutoff value the SNS displays a greater activation.

Methods: In 95 CKD middle-age patients we evaluated muscle sympathetic nerve activity (MSNA, microneurography) and venous plasma norepinephrine (HPLC assay), subdividing the patients in different groups according to their resting clinic and 24-h HR. Read More

J Vasc Surg Venous Lymphat Disord 2022 Jun 30. Epub 2022 Jun 30.

Division of Vascular Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY.

Objective: An active venous leg ulcer (VLU) caused by lower extremity venous insufficiency is challenging to treat and will often recur after initially healing. In the present study, we compared the symptomatic outcomes and need for reoperation after iliac vein stenting (IVS) in patients with an active VLU (VLU+) and those without an active VLU (VLU-).

Methods: A single-institution database of patients with chronic venous outflow obstruction who underwent IVS from August 2011 to June 2021 was analyzed. Read More

Sleep Breath 2022 Jul 1. Epub 2022 Jul 1.

Department of Nursing, Faculty of Health Science, Bartın University, Faculty Street, 2nd Floor, No. 201, Ağdacı Campus, 74100, Bartın, Turkey.

Purpose: This study aimed to assess the prevalence of poor sleep quality and to describe its predictors in diabetic patients having chronic venous insufficiency and varicose veins treated with cyanoacrylate glue.

Methods: This single-center, prospective cohort study was conducted between March 2018 and March 2021. A total of 103 patients with diabetes mellitus and chronic venous insufficiency (CEAP classification at stages C3-C6) treated with cyanoacrylate glue for varicose veins were recruited. Read More

Stud Health Technol Inform 2022 Jun;295:281-284

Health Informatics Research Group, Osnabrück University of AS, Germany.

Chronic wounds are ulcerations of the skin that fail to heal because of an underlying condition such as diabetes mellitus or venous insufficiency. The timely identification of this condition is crucial for healing. However, this identification requires expert knowledge unavailable in some care situations. Read More

Chirurgie (Heidelb) 2022 Jun 29. Epub 2022 Jun 29.

Gefäßchirurgie, Medizinische Fakultät, Universität Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

Background: The marginal vein (MV) is a congenital, predominantly venous vascular malformation, which is based on a lack of regression of the embryonic venous system in the lower extremities and is associated with a variety of complications. So far, no uniform treatment regimens have been described in the literature.

Objective: What are the treatment strategies and outcomes in patients with a MV?

Material And Methods: In the period from 1 January 2008 to 31 December 2020, all patients treated at the University Hospital Augsburg with MV were retrospectively reviewed. Read More

Bioengineered 2022 06;13(6):14138-14158

Department of Vascular Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.

Venous ulcer is a common contributor to chronic venous insufficiency (CVI) of lower limbs, which seriously affects the life quality of patients. In this study, we researched the expression characteristics of microRNA-301a-3p (miR-301a-3p) in patients with CVI and investigated the impact of miR-301a-3p on the dysfunction of human umbilical vein endothelial cells (HUVECs). The plasma level of miR-301a-3p in normal controls, patients with varicose great saphenous vein, and patients with the venous ulcer of lower limbs were measured. Read More

Vasc Endovascular Surg 2022 Jun 21:15385744221110440. Epub 2022 Jun 21.

Total Vascular Care, Brooklyn, NY, USA.

Objectives: Endovenous Radio-frequency Ablation (RFA) has become a common treatment for chronic venous insufficiency. The Medtronic Closurefast catheter was previously the only RFA catheter approved for use in this procedure. In 2018 VenClose Company's new device was approved. Read More

Exp Ther Med 2022 Jul 17;24(1):449. Epub 2022 May 17.

Clinic of Dermatology, County Emergency Hospital of Sibiu, 550245 Sibiu, Romania.

The role of hyperhomocysteinemia (HH) in the etiopathogenetics of systemic thrombotic events has been confirmed by numerous studies. However, it has been insufficiently studied as an etiopathogenic factor in chronic venous insufficiency (CVI). The present prospective study included 166 patients with CVI at stages C3-C6. Read More

Semin Nephrol 2022 03;42(2):129-141

Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Nephrologists are increasingly providing care to transgender, nonbinary, and gender diverse (TNBGD) individuals with chronic kidney disease. This narrative review discusses the care of TNBGD individuals from a nephrology perspective. TNBGD individuals are under-represented in the nephrology literature. Read More