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Dtsch Med Wochenschr 2019 Mar 14;144(6):398-410. Epub 2019 Mar 14.

In case of an acute leg swelling a deep leg vein thrombosis needs to be excluded. In order to do this, compression sonography and the D-dimer-test are applied in the framework of an established diagnostic algorithm. The ensuing therapy consists in anticoagulation and compression. Read More

Phlebology 2019 Mar 12:268355519833255. Epub 2019 Mar 12.

1 Department of Vascular Surgery, Zuyderland Medical Centre, Heerlen, The Netherland.

Background: Venous insufficiency of the lower extremity affects up to 40-60% of general adult population in the Western population, of which around 25% has varicose veins mostly treated by ablation of the incompetent great saphenous vein. Although endovenous options are available, the majority is still treated with stripping of the great saphenous vein for which there is no consensus regarding postoperative compressive therapy. The objective of this prospective randomised controlled trial was to evaluate 4 h compared to 72 h of leg compression after great saphenous vein stripping. Read More

Int Angiol 2019 Feb;38(1):70-75

College of Medical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.

Background: Lower extremity edema occurs in many conditions including congestive heart failure, lymphedema, diabetes-related, kidney and liver disease, chronic venous insufficiency with venous hypertension. Clinical edema assessment methods are often subjective and variable. Our goals were to introduce a simple noninvasive measurement procedure potentially useful to characterize lower extremity edema by providing normative values from which edema thresholds might emerge. Read More

Eur J Vasc Endovasc Surg 2019 Mar 5. Epub 2019 Mar 5.

Department of Surgery & Cancer, Imperial College London, Charing Cross Hospital, London, UK. Electronic address:

Objective/background: The aim was to summarise the evidence for the relationship between vein diameters and clinical severity, and elucidate the relationship between diameters and health related quality of life (HRQoL) METHODS: A systematic review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. The MEDLINE and Embase databases were searched from 1946 to 31 August 2018. Reference lists of included studies were searched for further relevant papers. Read More

Rev Med Chil 2019 ;147(1):41-46

Departamento de Cirugía Vascular y Endovascular, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Pelvic venous insufficiency may cause pelvic congestion syndrome that is characterized by chronic pelvic pain exacerbated by prolonged standing, sexual activity or menstrual cycle. It may be treated by embolizing the dysfunctional pelvic venous drainage and sometimes resecting vulvar, perineal and thigh varices.

Aim: To assess the results of embolization of insufficient pelvic or ovarian veins on pelvic congestion syndrome. Read More

Vasa 2019 Mar 8:1-6. Epub 2019 Mar 8.

2 Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia.

Background: The mechanism for post-thrombotic syndrome (PTS), the most important long-term sequelae of deep venous thrombosis, is not entirely known. It is probably caused by venous hypertension due to venous insufficiency and venous obstruction. Venous hypertension could also be a consequence of the May-Thurner syndrome (MTS), i. Read More

BMC Geriatr 2019 Mar 7;19(1):76. Epub 2019 Mar 7.

Division of Health Services, Norwegian Institute of Public Health, Box 4404 Nydalen, 0130, Oslo, Norway.

Background: Many home-dwelling elderly use medical compression stockings to prevent venous insufficiency, deep venous thrombosis, painful legs and leg ulcers. Assisting users with applying and removing compression stockings demands resources from the home based health services, but the effects are uncertain. This systematic review aims to summarize the effects of preventive use of medical compression stockings for patients with chronic venous insufficiency and swollen legs. Read More

Vasa 2019 Mar 6:1-7. Epub 2019 Mar 6.

3 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

Background: Elastic compression therapy (CT) in patients with peripheral artery disease (PAD) and chronic venous insufficiency (CVI) may compromise arterial perfusion. We evaluated the feasibility of a toe-flexion test, which quantifies dynamic foot perfusion by near-infrared spectroscopy (NIRS), for the assessment of hemodynamic sustainability of CT in PAD patients with CVI.

Patients And Methods: In this prospective observational study, PAD patients aged 50-85 with combined CVI at CEAP stages II-IV were studied. Read More

Niger J Clin Pract 2019 Mar;22(3):399-405

Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Background: Ultrasound-accelerated catheter-directed thrombolysis (UCT) increases the invasion of thrombolytic agent into the thrombus using ultrasonic energy, provides less infusion of thrombolytic agent, reduces complication, and post-thrombotic syndrome (PTS) development rates. For these reasons, this procedure is a promising method for the treatment of deep vein thrombosis (DVT).

Materials And Methods: Patients diagnosed with DVT by ultrasonography (USG) who underwent UCT between May 2013 and August 2014 at Gazi University Hospital Cardiovascular Surgery Clinic were included in the study. Read More

Curr Pain Headache Rep 2019 Mar 4;23(3):16. Epub 2019 Mar 4.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Purpose Of Review: Chronic venous disease (CVD), although affecting up to 40% of the US population, is often underdiagnosed by healthcare professionals due to an incomplete understanding of the presenting symptoms. CVD is a common cause of lower extremity pain and discomfort, including aching, cramping, tingling, burning, swelling, heaviness, restlessness, and fatigue, and may lead to significant morbidity if left untreated. The negative impact of CVD on quality of life is well established and the optimization of management strategies is an important area of evolving research. Read More

Ont Health Technol Assess Ser 2019 19;19(2):1-86. Epub 2019 Feb 19.

Background: People with chronic venous insufficiency who develop leg ulcers face a difficult condition to treat. Venous leg ulcers may persist for long periods of time and have a negative impact on quality of life. Treatment requires frequent health care provider visits, creating a substantial burden across health care settings. Read More

Ann Vasc Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Vascular & Endovascular Surgery Wellington Street, Perth, 6000, Western Australia.

Objective: Aim of the study was to assess results of interventions for iliocaval obstruction or compression in patient with acute and chronic venous disease.

Methods: Patients with chronic venous insufficiency (CVI) C3-C6 (CEAP classification) and acute DVT were assessed by ultrasound scan, CT, venography and/or IVUS, and if an obstruction in their iliocaval or iliofemoral segments were confirmed, they underwent venoplasty and stenting. Acute DVT cases were treated with pharmaco-mechanical and/or catheter-directed thrombolysis and residual obstruction was then stented. Read More

Minim Invasive Ther Allied Technol 2019 Feb 22:1-7. Epub 2019 Feb 22.

c Department of Vascular Surgery , Emam Khomeini Hospital, Tehran University of Medical Science , Tehran , Iran.

Introduction: Venous outflow obstruction is a common condition among patients with chronic venous insufficiency. Endovascular treatment is favourable over open surgery. This study aimed to assess stent patency and clinical outcome in venous outflow obstruction of lower limbs, and also to compare it between post-thrombotic syndrome and non-thrombotic iliac vein lesions. Read More

Khirurgiia (Mosk) 2019 (1):37-42

Voyno-Yasenetsky Krasnoyarsk State Medical University of Healthcare Ministry of the Russia, Krasnoyarsk, Russia.

Aim: To analyze efficiency of ozone therapy, ultrasound and cryotherapy for infected and purulent wounds due to chronic venous insufficiency.

Material And Methods: There were 127 patients with chronic venous insufficiency followed by chronic wounds. Efficacy of systemic and local ozone therapy was assessed. Read More

J Vasc Surg Venous Lymphat Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Soonchunhyang University Seoul Hospital, Seoul, Korea. Electronic address:

Objective: Preoperative mapping of great saphenous vein (GSV) escape points to tributary veins (TVs) and targeted intervention of escape points may reduce recurrence rates of varicose veins (VVs) after endovascular treatment of saphenous veins and prevent saphenous nerve complications. The aim of this study was to perform an analysis of cartography after Doppler ultrasound mapping of escape points in patients with VVs and to suggest one point that may prevent recurrence and nerve complications.

Methods: Ultrasound assessment of VVs was performed from March 4, 2016, to July 15, 2016, specifically focusing on the locations of escape points from the saphenous vein to TVs. Read More

Eur J Vasc Endovasc Surg 2019 Feb 16. Epub 2019 Feb 16.

Jobst Vascular Institute of ProMedica, and University of Michigan Ann Arbor, 2109 Hughes Drive, Suite 400, Toledo, OH 43551, USA. Electronic address:

Arch Med Sci Atheroscler Dis 2018 15;3:e156-e163. Epub 2018 Dec 15.

Department of Cardiovascular Surgery, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Introduction: Venous leg ulcers (VLUs), which arise from chronic venous insufficiency in the lower limbs, are a major cause of morbidity and significantly negatively impact patients' health-related quality of life. Treatment of venous ulcers can be either conservative or surgical. Despite appropriate treatment, VLUs can be resistant to healing. Read More

J Wound Care 2019 Feb;28(2):59-65

Head of Center for Human Molecular Genetics and Pharmacogenomics, Professor of Biochemistry and Genetics; University of Maribor, Faculty of Medicine, Center for human molecular genetics and pharmacogenomics, Taborska ulica 8, SI-2000 Maribor, Slovenia. University of Maribor, Faculty for Chemistry and Chemical engineering, Laboratory for Biochemistry, Molecular Biology and Genomics, Smetanova 17, SI-2000 Maribor, Slovenia.

Chronic wounds represent a major socioeconomic problem. Chronic venous ulceration is one of the least well-understood types of chronic wounds. A chronic venous ulcer arises as a result of chronic venous insufficiency (CVI), which affects approximately 10-35% of people in the developed world, yet not all people with CVI develop ulceration. Read More

J Vasc Surg Venous Lymphat Disord 2019 Feb 11. Epub 2019 Feb 11.

Division of Vascular Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objective: The aim of this study was to investigate the prevalence and clinical predictors of >50% iliocaval venous obstruction (ICVO) in Thai patients with lipodermatosclerosis and healed or active venous ulcers and the diagnostic accuracy of duplex ultrasound (DUS) compared with computed tomography venography (CTV).

Methods: Limbs with lipodermatosclerosis, healed venous leg ulceration, or active venous leg ulceration were prospectively evaluated by DUS and CTV. Loss of respiratory variation in the common femoral vein (CFV) and reversed flow in the superficial epigastric vein (SEV) were evaluated by DUS. Read More

Adv Ther 2019 Feb 13. Epub 2019 Feb 13.

Fundación Santa Fe de Bogotá, Universidad de Los Andes, Bogotá, Colombia.

Chronic venous disease (CVD) is both prevalent and unavoidable in many people as a result of persistent or unalterable risk factors, the most important of which are advanced age, excess body weight, and family history. Given this inevitability, medical treatment is required to alleviate symptoms and slow disease progression. Venoactive drug therapy is emerging as a valuable treatment option for many CVD patients and micronized purified flavonoid fraction (MPFF) is the most widely prescribed and well-studied venoactive drug available. Read More

Adv Ther 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY, USA.

Risk factors for the development of progression chronic venous disease (CVD) and varicose veins are widespread and include advanced age, excess body weight, sedentary lifestyles and occupations, family history, and pregnancy. Varicose veins and CVD are associated with venous hypertension, venous reflux, dysfunctional venous valves, and vein wall inflammation, though the precise etiologies are unclear. Once venous pathology develops, it can progress through a vicious cycle of inflammation and leukocyte recruitment that leads to further deterioration of vein walls and valves, increased hypertension, and release of additional proinflammatory mediators. Read More

Adv Ther 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY, USA.

Chronic venous disease (CVD) is widespread, underdiagnosed, and can progress to chronic venous insufficiency and venous ulcers, which can require extensive treatment and hospitalization. These conditions negatively impact patient quality of life and place substantial burdens on healthcare resources. The two main risk factors for CVD are age and obesity. Read More

Adv Ther 2019 Feb 13. Epub 2019 Feb 13.

Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK.

Chronic venous disease (CVD) is a prevalent condition that tends to worsen with age. Patients initially seek treatment to relieve symptoms of leg pain, discomfort, heaviness and swelling, all of which impact their quality of life. As the disease increases in severity to include varicose veins, skin changes, and venous ulcer, the demand for treatment increases while the quality of life further diminishes. Read More

Vascular 2019 Feb 10:1708538118823838. Epub 2019 Feb 10.

Department of Cardiovascular Surgery, VM Medical Park Samsun Hospital, Samsun, Turkey.

Objectives: This study aims to present the early results of a prospective study of the use of novel n-butyl-2 cyanoacrylate (VenaBlock)-based nontumescent endovenous ablation with a guiding light for the treatment of patients with varicose veins.

Methods: Five hundred and seventy-three patients with lower-limb venous insufficiency were treated within in the previous four years. The study enrolled adults aged 21-70 years with symptomatic moderate to severe varicosities (C2-C6 patients clinical, etiological, anatomical, and pathophysiological classification) and great saphenous vein reflux lasting longer than 0. Read More

J Vasc Surg Cases Innov Tech 2019 Mar 28;5(1):45-48. Epub 2019 Jan 28.

Department of Surgery, Atlantic Health System Morristown Medical Center, Morristown, NJ.

Klippel-Trenaunay syndrome is a rare disorder consisting of the triad of vascular and/or lymphatic malformations, capillary malformations, and soft tissue or bony hypertrophy. Symptom control is the mainstay of treatment for these patients, with many of the symptoms never fully being relieved. In this case report, we present the case of a 46-year-old man with chronic lower extremity ulcerations unresponsive to wound care therapy. Read More

Eur J Trauma Emerg Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedics and Traumatology, University Medical Center of Johannes Gutenberg-University Mainz, Mainz, Germany.

The number of geriatric patients is increasing. These patients exhibit specific characteristics, which influence the type of fracture care. Many patients have comorbidities, which make them more vulnerable to surgical procedures. Read More

Ter Arkh 2018 May;90(5):55-60

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.

Aim: The study of the course and outcomes of panniculitis (PN) in modern rheumatology practice.

Materials And Methods: We observed 209 patients (pts) (f-185, m-24 in age 17 to 80 years) with the input diagnosis "Erythema nodosum? Undifferentiated panniculitis?" and duration of illness in from 1 week to 25 years, observed in V.A. Read More

Wounds 2019 Feb;31(2):65-67

Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

The calf muscles have been called the body's "second heart," improving blood circulation when exercised, usually by walking. Structured exercise training (SET) increases calf muscle pump function, lower limb circulation, and walking capacity for those with limited ambulation due to peripheral arterial disease (PAD)1 or venous insufficiency.2 This resulted in the Centers for Medicare and Medicaid Services (CMS) decision to reimburse up to thirty-six 30- to 60-minute, properly supervised hospital outpatient or office-based SET sessions over 12 weeks to treat intermittent claudication for patients with PAD. Read More

Phlebology 2019 Jan 28:268355519826008. Epub 2019 Jan 28.

2 Department of General Surgery, Changi General Hospital, Singapore.

Objectives: The aim of this prospective single-centre study is to assess the effectiveness and patient experience of the VenaSeal™ Closure System, a novel non-thermal, non-tumescent catheter technique, which uses cyanoacrylate glue to occlude the refluxing truncal superficial veins to treat varicose veins and chronic venous insufficiency, in a multi-ethnic Asian population from Singapore.

Methods: Seventy-seven patients (93 legs; 103 procedures) underwent VenaSeal™ Closure System ablation. Forty-nine (63. Read More

Phlebology 2019 Jan 24:268355519825590. Epub 2019 Jan 24.

3 Sir Charles Gairdner Hospital, Perth, WA, Australia.

Compression bandaging remains the 'gold standard' intervention for the treatment of venous leg ulcers. Numerous studies have investigated the effect of a large variety of compression bandaging techniques and materials on venous leg ulcer healing. However, the majority of these studies failed to monitor both actual bandage application pressures and the bandaging competency of participating clinicians. Read More

Rev Assoc Med Bras (1992) 2018 Aug;64(8):729-735

. Medical Science Faculty of the Santa Casa of São Paulo, São Paulo/SP, Brasil.

Objective: This study aims to correlate the demographic data, different clinical degrees of chronic venous insufficiency (CEAP), ultrasound findings of saphenofemoral junction (SFJ) reflux, and anatomopathological findings of the proximal segment of the great saphenous vein (GSV) extracted from patients with primary chronic venous insufficiency (CVI) submitted to stripping of the great saphenous vein for the treatment of lower limb varicose.

Method: This is a prospective study of 84 patients (110 limbs) who were submitted to the stripping of the great saphenous vein for the treatment of varicose veins of the lower limbs, who were evaluated for CEAP clinical classification, the presence of reflux at the SFJ with Doppler ultrasonography, and histopathological changes. We study the relationship between the histopathological findings of the proximal GSV withdrawal of patients with CVI with a normal GSV control group from cadavers. Read More

Eur J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

University of Genoa, Dissal, Department of Dermatology, San Martino Policlinic Hospital, Genoa, Italy.

Chronic wounds include arterial, venous, diabetic and pressure ulcers. The term "chronic wound" defines wounds that have not healed within three months. The possible causes that transform a simple wound into a chronic one are the object of study, and research has focused on infection as one of the crucial factors in producing and maintaining chronic wounds. Read More

J Vasc Surg Venous Lymphat Disord 2019 Mar 14;7(2):210-216. Epub 2019 Jan 14.

Department of Cardiovascular Surgery, Medical School of Eskişehir Osmangazi University, Eskişehir, Turkey.

Objective: In this study, the clinical results of radiofrequency ablation (RFA) and n-butyl-cyanoacrylate embolization (CAE) methods were compared in the treatment of incompetent great saphenous veins (GSVs).

Methods: We analyzed retrospectively 244 patients (128 patients in the RFA group, 116 patients in the CAE group) with incompetent GSVs who were treated with RFA and CAE according to the patients' choice between June 2013 and June 2016. All patients were thoroughly examined preoperatively and at 1, 3, 6, and 12 months after the operation, and the clinical results and the quality of life were evaluated. Read More

Curr Health Sci J 2018 Jul-Sep;44(3):235-242. Epub 2018 Jul 15.

Medical Center Dr. Ianosi, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania.

In the last two decades Nd: YAG laser has become a standard of treatment of telangiectasias of the lower limbs in CEAP stage of chronic venous insufficiency. This paper shows the results of a two years study period of telangiectasias of lower limbs with Nd: YAG laser conducted in a specialised centre in this type of procedures. The study group consisted of 446 patients (21 males and 425 females) with telangiectasias (CEAP) on the lower limbs between January 2016-December 2017. Read More

Int J Vasc Med 2018 2;2018:5437678. Epub 2018 Dec 2.

Karaman State Hospital, Department of Cardiology, 70100 Karaman, Turkey.

Background And Objectives: Chronic venous insufficiency (CVI) is a common pathology of the circulatory system and is associated with a high morbidity for the patients and causes high costs for the healthcare systems. Arterial stiffness has been shown to be a predictor of cardiovascular events and mortality. The relationship between CVI and arterial stiffness using pulse wave velocity (PWV) and augmentation index (Aix) was evaluated in this study. Read More

Kardiologiia 2018 Dec 25;58(12):60-65. Epub 2018 Dec 25.

Pirogov Russian National Research Medical University (RNRMU).

Purpose: to elucidate predictors of development of chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary artery thromboembolism (PTE).

Material And Methods: We included in this study 210 patients hospitalized with diagnosis of submassive and massive PTE from 2013 to 2017. In 1 to 3 years after initial hospitalization these patients were invited for control examination. Read More

J Vasc Surg Venous Lymphat Disord 2019 Mar 6;7(2):228-233. Epub 2019 Jan 6.

Division of Vascular Surgery, Department of Surgery, University of Maryland School of Medicine and Baltimore Veterans Administration Medical Center, Baltimore, Md. Electronic address:

Objective: Chronic venous leg ulcers (VLUs) affect up to 2% of the general population, resulting in a significant socioeconomic burden. Placental tissue that contains mesenchymal stem cells and active growth factors has been shown to be beneficial in healing of chronic wounds. We compared the efficacy of a human viable wound matrix (hVWM) of cryopreserved placental tissue for the treatment of refractory VLUs with standard therapy. Read More

Praxis (Bern 1994) 2019 Jan;108(1):31-36

1 Institut für Physiologie und Pathophysiologie, Abteilung Herz- und Kreislaufphysiologie, Universität Heidelberg, Deutschland.

Drug-Based Therapy of Varicose Veins from the Perspective of Experimental Models Abstract. Varicose remodeling of the venous wall primarily occurs in the lower extremities and is often associated with venous insufficiency. Although a large part of the western population shows various degrees of varicosis, little is known about the mechanisms driving their formation. Read More

Phlebology 2019 Jan 7:268355518822582. Epub 2019 Jan 7.

Department of Vascular Surgery, Waikato Hospital, Hamilton, New Zealand.

Objectives: This study aimed to determine if compression therapy or surgical intervention improves tissue oxygenation in chronic venous disease.

Method: Thirty lower limbs with chronic venous disease were placed into three groups, being compression, open surgical and endovenous ablation. Tissue oxygenation was assessed using a hyperspectral transcutaneous oxygen measurement system. Read More

Cureus 2018 Oct 27;10(10):e3504. Epub 2018 Oct 27.

Plastic Surgery, Reading Hospital, Wyomissing, USA.

Chronic venous insufficiency (CVI) and venous leg ulcers (VLUs) have major financial implications for patients and healthcare professionals. VLUs, in particular, require significant care, can be slow to heal, and have a high rate of recurrence. These factors combine to make VLUs a major burden on the healthcare system. Read More

J Robot Surg 2019 Jan 4. Epub 2019 Jan 4.

Department of Vascular and Endovascular Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.

Robotic-assisted surgical approaches for vascular surgery are feasible regarding minimally invasive exposure, dissection, ligation and skeletonization for varicose vein ligation, anterior spine exposure, femoral-popliteal bypass, femoral vein harvest and aortic aneurysm repair. The authors performed a cadaveric exploration to demonstrate proof of concept and feasibility for a robotic-assisted approached. Surgeon autonomy over endoscopic vision, robotic instrumentation and retraction were noted as key benefits over existing open vascular approaches. Read More

BMJ Open 2019 Jan 3;9(1):e023313. Epub 2019 Jan 3.

Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida, USA.

Introduction: Chronic venous insufficiency (CVI) affects up to one-third of the adult population yet venous leg ulcers (VLU), a significant complication of CVI, only affect 1%-2% of adults in the USA. Why some develop VLU and others do not is unclear. VLU have a significant impact on quality of life and are extremely costly and difficult to treat. Read More

Vnitr Lek 2018 ;64(11):1098-1104

Chronic non-healing wounds represent a frequent comorbidity among geriatric patients. Non-healing wounds increase patients morbidity and mortality and significantly decrease their quality of life. Prognosis of these wounds depends on etiology, overall health condition of the patient and also on the proper treatment. Read More

Heart Surg Forum 2018 11 14;21(6):E472-E475. Epub 2018 Nov 14.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea.

Chronic venous disease is strongly associated with morbidity and leads to considerable medical costs. Therefore, its clinical significance is very important. Currently, iliac vein stenting is the first treatment option for chronic venous disease due to iliac vein obstruction. Read More

J Cosmet Dermatol 2019 Jan 1. Epub 2019 Jan 1.

Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

Pigmented purpuric dermatoses (PPD) or capillaritis represent a benign condition, presenting with extravasation of erythrocytes in the skin and prominent hemosiderin deposition. The eruption runs a chronic relapsing course and is resistant to therapy. Capillary fragility, cellular immunity, and microvascular inflammation play important roles in the pathogenesis of PPD. Read More

PLoS One 2018 31;13(12):e0208954. Epub 2018 Dec 31.

Department of Medical Science, McMaster University, Hamilton, Ontario, Canada.

Background: Chronic Venous Disease is characterized by morphological abnormalities of the venous system. Affected limbs are classified in increasing clinical severity with the Clinical Etiological Anatomical and Pathological system from C0 to C6. Limbs assessed at C3 through C6 meet the criteria of Chronic Venous Insufficiency. Read More

Phlebology 2018 Dec 30:268355518818339. Epub 2018 Dec 30.

Hull York Medical School, Academic Vascular Surgical Unit, Alderson House, Hull Royal Infirmary, Hull, UK.

Background: Mechanochemical ablation is an innovative non-thermal method of treating symptomatic axial superficial venous incompetence. This is a single-centre cohort study aiming to investigate the technical efficacy and clinical effectiveness at one year.

Methods: Patients with primary, unilateral, symptomatic axial incompetence were offered treatment with mechanochemical ablation using ClariVein® with 1. Read More

Eur J Haematol 2019 Apr 7;102(4):312-318. Epub 2019 Feb 7.

The Division of Hematology & Oncology, School of Medicine, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Direct oral anticoagulants (DOACs) have been shown to be superior to vitamin K antagonists (VKAs) in regards to safety and efficacy in numerous clinical trials and are now the preferred oral anticoagulant by multiple professional societies. However, patients with significant levels of organ dysfunction were excluded from all major clinical trials, leaving the clinical benefit in these subsets uncertain. Patients with chronic kidney disease (CKD) specifically often require anticoagulation for acute or long-term indications such as venous thromboembolism, atrial fibrillation, or mechanical heart valves. Read More

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Dermatological Clinic of the university of Greifswald, Germany.

Background: Chronic venous disease (CVD) is extremely common worldwide with prevalence increasing with age. It is associated with a reduced quality of life, particularly in relation to pain, physical function and mobility. Symptomatic chronic venous insufficiency (CVI) with venous ulcer at its, endpoint, indicates interventional surgery to cure venous reflux therewith promoting wound healing and preventing recurrence. Read More