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    521 results match your criteria Chronic Respiratory Disease[Journal]

    1 OF 11

    Impact of cataract on health-related quality of life in a longitudinal Japanese chronic obstructive pulmonary cohort.
    Chron Respir Dis 2017 Jan 1:1479972317745735. Epub 2017 Jan 1.
    1 Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
    Cigarette smoking increases the risk of developing both cataract and chronic obstructive pulmonary disease (COPD). The prevalence of cataract and the clinical characteristics of COPD patients with cataract were retrospectively investigated in a 2-year observational COPD cohort. We analyzed 395 patients with complete data on ophthalmologic evaluation (319 subjects with COPD and 76 subjects at risk of COPD). Read More

    Does antibiotic treatment duration affect the outcomes of exacerbations of asthma and COPD? A systematic review.
    Chron Respir Dis 2017 Jan 1:1479972317745734. Epub 2017 Jan 1.
    3 Department of Respiratory Medicine, Royal Liverpool University Hospital, Liverpool, UK.
    Asthma and chronic obstructive pulmonary disease (COPD) cause significant morbidity and mortality worldwide, primarily through exacerbations. Exacerbations are often treated with antibiotics but their optimal course duration is uncertain. Reducing antibiotic duration may influence antimicrobial resistance but risks treatment failure. Read More

    Dose uniformity of budesonide Easyhaler® under simulated real-life conditions and with low inspiration flow rates.
    Chron Respir Dis 2017 Jan 1:1479972317745733. Epub 2017 Jan 1.
    3 Orion Corporation, Orion Pharma, Kuopio, Finland.
    Budesonide Easyhaler® multidose dry powder inhaler is approved for the treatment of asthma. Objectives were to determine the delivered dose (DD) uniformity of budesonide Easyhaler® in simulated real-world conditions and with different inspiration flow rates (IFRs). Three dose delivery studies were performed using 100, 200, and 400 µg/dose strengths of budesonide. Read More

    Reluctance of patients with chronic obstructive pulmonary disease in its early stages and their families to participate in a partnership-based self-management trial: A search for explanation.
    Chron Respir Dis 2017 Jan 1:1479972317743758. Epub 2017 Jan 1.
    1 Faculty of Nursing, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
    Recruitment, the process of accessing, screening, selecting and retaining participants for research remains a challenge. In a randomized controlled trial, partnership-based self-management intervention for patients who have chronic obstructive pulmonary disease (COPD) in its initial stages, and their families, a theoretical framework developed for patients with an advanced COPD and their families was modified and implemented in a primary care context. In contrast to recruitment to the original study where 4% decline participation, in this study 25% of the potential patients declined participation. Read More

    Sarcopenia in chronic obstructive pulmonary disease: A study of prevalence and associated factors in the Southeast Asian population.
    Chron Respir Dis 2017 Jan 1:1479972317743759. Epub 2017 Jan 1.
    5 Division of Ambulatory Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
    Chronic obstructive pulmonary disease (COPD) has been described as a systemic disease. Sarcopenia is one of the systemic effects that is related to several adverse outcomes. The objectives of this study were to estimate the prevalence of sarcopenia and to determine the factors associated with sarcopenia in COPD patients in Southeast Asia. Read More

    Daily spirometry in an acute exacerbation of adult cystic fibrosis patients.
    Chron Respir Dis 2017 Jan 1:1479972317743756. Epub 2017 Jan 1.
    3 Division of Pulmonary and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
    To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation requiring intravenous antibiotics had a daily FEV1. The average time to a 10% increase over their initial sick FEV1 was calculated, as well as the time to a new baseline. Read More

    Clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease.
    Chron Respir Dis 2017 Jan 1:1479972317743757. Epub 2017 Jan 1.
    1 Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training Hospital, University of Health Sciences, İstanbul, Turkey.
    The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. Read More

    What kind of information and communication technologies do patients with COPD prefer to use? A cross-sectional study in Latin America.
    Chron Respir Dis 2017 Jan 1:1479972317741895. Epub 2017 Jan 1.
    5 Centro de Investigación en Salud Pública y Epidemiología Clínica, Universidad Tecnológica Equinoccial, Quito, Ecuador.
    The aim of the present study was to assess the frequency of uses and preferences of information and communication technologies (ICTs) among Latin American chronic obstructive pulmonary disease (COPD) patients. We conducted an anonymous cross-sectional survey study on Latin American COPD patients. The adapted version of the Michigan questionnaire was employed in eligible outpatients in different cities of Latin America. Read More

    Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans.
    Chron Respir Dis 2017 Jan 1:1479972317741896. Epub 2017 Jan 1.
    1 Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa Prefecture, Japan.
    The objective of this study was to investigate the relationship between the extent of emphysema and heart size in patients with chronic obstructive pulmonary disease (COPD) using inspiratory and expiratory chest computed tomography (CT). This retrospective study was approved by the institutional review board and informed consent was waived. We measured lung volume (LV), low attenuation area percent (%LAA; less than or equal to -950 HU), maximum cardiac area, and maximum transverse cardiac diameter on inspiratory/expiratory chest CT in 60 patients with COPD. Read More

    Inflammatory biomarkers and radiologic measurements in never-smokers with COPD: A cross-sectional study from the CODA cohort.
    Chron Respir Dis 2017 Jan 1:1479972317736293. Epub 2017 Jan 1.
    1 Samsung Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Various biomarkers have emerged as potential surrogates to represent various subgroups of chronic obstructive pulmonary disease (COPD), which manifest with different phenotypes. However, the biomarkers representing never-smokers with COPD have not yet been well elucidated. The aim of this study was to evaluate the associations of certain serum and radiological biomarkers with the presence of COPD in never-smokers. Read More

    Obesity and metabolic syndrome in COPD: is exercise the answer?
    Chron Respir Dis 2017 Jan 1:1479972317736294. Epub 2017 Jan 1.
    2 National Centre for Sport and Exercise Medicine, School of Sport Exercise and Health Sciences, Loughborough University, Loughborough, UK.
    Approximately half of all patients with chronic obstructive pulmonary disease (COPD) attending pulmonary rehabilitation (PR) programmes are overweight or obese which negatively impacts upon dyspnoea and exercise tolerance particularly when walking. Within the obese population (without COPD), the observed heterogeneity in prognosis is in part explained by the variability in the risk of developing cardiovascular disease or diabetes (cardiometabolic risk) leading to the description of metabolic syndrome. In obesity alone, high-intensity aerobic training can support healthy weight loss and improve the constituent components of metabolic syndrome. Read More

    Effects of varenicline therapy in combination with advanced behavioral support on smoking cessation and quality of life in inpatients with acute exacerbation of COPD, bronchial asthma, or community-acquired pneumonia: A prospective, open-label, preference-based, 52-week, follow-up trial.
    Chron Respir Dis 2017 Jan 1:1479972317740128. Epub 2017 Jan 1.
    2 Department of Respiratory Medicine, Medical School, University of Thessaly, Larissa, Greece.
    Quitting smoking is the most important element in the therapeutic management of chronic respiratory diseases. Combining pharmacotherapy with behavioral support increases smoking cessation success rates. In addition, hospitalized smokers have increased motivation to quit. Read More

    High-sensitivity cardiac troponin T in obstructive sleep apnea patients without cardiovascular diseases: Efficacy of CPAP treatment.
    Chron Respir Dis 2017 Jan 1:1479972317740127. Epub 2017 Jan 1.
    1 Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
    The aims of this article were to determine the levels of serum high-sensitivity cardiac troponin T (hs-cTnT) in obstructive sleep apnea (OSA) patients without cardiovascular disease (CVD) and to assess the efficacy of continuous positive airway pressure (CPAP). Snorers referred for polysomnography (PSG) for the investigation of OSA were eligible and hs-cTnT levels measured in our pilot study. Hs-cTnT was measured again after 3 months of CPAP treatment in participants with severe OSA. Read More

    Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis.
    Chron Respir Dis 2017 Nov 6;14(4):392-406. Epub 2017 Mar 6.
    1 Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
    Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder associated with severely impaired mucociliary clearance caused by defects in ciliary structure and function. Although recurrent bacterial infection of the respiratory tract is one of the major clinical features of this disease, PCD airway microbiology is understudied. Despite the differences in pathophysiology, assumptions about respiratory tract infections in patients with PCD are often extrapolated from cystic fibrosis (CF) airway microbiology. Read More

    Health status of COPD patients undergoing pulmonary rehabilitation: A comparative responsiveness of the CAT and SGRQ.
    Chron Respir Dis 2017 Nov 15;14(4):352-359. Epub 2017 Mar 15.
    5 Department of Medicine, Faculty of Medicine and Surgery; University of Malta, Msida, Malta.
    The St. George's Respiratory Questionnaire (SGRQ) and chronic obstructive pulmonary disease (COPD) assessment test (CAT) are the measures used to assess health status. This study aims to examine the responsiveness of these tools by severity of dyspnoea category in patients with COPD. Read More

    Home-based pulmonary rehabilitation for people with COPD: A qualitative study reporting the patient perspective.
    Chron Respir Dis 2017 Jan 1:1479972317729050. Epub 2017 Jan 1.
    1 Department of Physiotherapy, La Trobe University, Melbourne, VIC, Australia.
    This study aimed to document the perspective of patients with chronic obstructive pulmonary disease (COPD) who underwent home-based pulmonary rehabilitation (HBPR) in a clinical trial. In this qualitative study, open-ended questions explored participants' views regarding HBPR. Thirteen semi-structured interviews were analysed using a thematic analysis approach. Read More

    Shuttle walk tests in people with COPD who demonstrate exercise-induced oxygen desaturation: An analysis of test repeatability and cardiorespiratory responses.
    Chron Respir Dis 2017 Jan 1:1479972317729051. Epub 2017 Jan 1.
    1 Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, Lidcombe, New South Wales, Australia.
    Exercise-induced oxygen desaturation (EID) is prevalent in people with chronic obstructive pulmonary disease (COPD). This article reports a sub-analysis from a randomized controlled trial (RCT) in people with COPD and EID (COPD/EID). The primary aim, in people with COPD/ EID, was to determine the repeatability of the distance and time walked in the incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT), respectively. Read More

    Telehealth pulmonary rehabilitation: A review of the literature and an example of a nationwide initiative to improve the accessibility of pulmonary rehabilitation.
    Chron Respir Dis 2017 Jan 1:1479972317724570. Epub 2017 Jan 1.
    1 Department of Medicine, Faculty of Medicine, University of Alberta, Edmonton, Canada.
    Several different applications of telehealth technologies have been used in the care of respiratory patients, including telemonitoring, teleconsultations, tele-education, and telehealth-pulmonary rehabilitation (PR). Telehealth technology provides an opportunity to assist in the management of chronic respiratory diseases and improve access to PR programs. While there is inconclusive evidence as to the effectiveness of telemonitoring to reduce healthcare utilization and detection of exacerbations, teleconsultations have been shown to be an effective means to assess patients' disease prior to the initiation of PR, and telehealth PR has been shown to be as effective as institution-based PR at improving functional exercise capacity and health-related quality of life. Read More

    How do patients conceptualize chronic obstructive pulmonary disease?
    Chron Respir Dis 2017 Aug 19;14(3):245-255. Epub 2016 Dec 19.
    1 Department of Family Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
    Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States, yet even at risk or diagnosed patients misunderstand COPD and its consequences for their quality of life and mortality. This study explored how patients conceptualize the causes, symptoms, consequences, treatment, and risk for developing COPD. The study consisted of six focus groups: 39 participants who were adults > 40 and current smoker or have COPD symptoms, family history, or exposures. Read More

    Effect of respiratory rehabilitation techniques on the autonomic function in patients with chronic obstructive pulmonary disease: A systematic review.
    Chron Respir Dis 2017 Aug 15;14(3):217-230. Epub 2016 Dec 15.
    1 Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Belgium.
    Patients with chronic obstructive pulmonary disease (COPD) show several extrapulmonary abnormalities such as impairment in the autonomic function (AF). Similarly, the use of respiratory training techniques such as controlled breathing techniques, noninvasive mechanical ventilation (NIMV), and oxygen supplementation for AF modulation in patients with COPD is popular in existing literature. However, the evidence to support their use is nonexistent. Read More

    APACHE II score cannot predict successful weaning from prolonged mechanical ventilation.
    Chron Respir Dis 2017 Aug 24;14(3):270-275. Epub 2017 Feb 24.
    3 Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    At least 5% of all intensive care unit patients require prolonged respiratory support. Multiple factors have been suggested as possible predictors of successful respiratory weaning so far. We sought to verify whether the Acute Physiology and Chronic Health Evaluation II (APACHE II) can predict freedom from prolonged mechanical ventilation (PMV) in patients treated in a regional weaning centre. Read More

    Validity and reliability of strain gauge measurement of volitional quadriceps force in patients with COPD.
    Chron Respir Dis 2017 Aug 24;14(3):289-297. Epub 2017 Feb 24.
    1 Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, Belgium.
    This study investigated the validity and reliability of fixed strain gauge measurements of isometric quadriceps force in patients with chronic obstructive pulmonary disease (COPD). A total cohort of 138 patients with COPD were assessed. To determine validity, maximal volitional quadriceps force was evaluated during isometric maximal voluntary contraction (MVC) manoeuvre via a fixed strain gauge dynamometer and compared to (a) potentiated non-volitional quadriceps force obtained via magnetic stimulation of the femoral nerve (twitch (Tw); n = 92) and (b) volitional computerized dynamometry (Biodex; n = 46) and analysed via correlation coefficients. Read More

    Physical activity, sedentary behaviour and sleep in COPD guidelines: A systematic review.
    Chron Respir Dis 2017 Aug 24;14(3):231-244. Epub 2017 Feb 24.
    1 Alliance for Research in Exercise, Nutrition and Activity, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
    Objectives: Physical activity, sedentary and sleep behaviours have strong associations with health. This systematic review aimed to identify how clinical practice guidelines (CPGs) for the management of chronic obstructive pulmonary disease (COPD) report specific recommendations and strategies for these movement behaviours.

    Methods: A systematic search of databases (Medline, Scopus, CiNAHL, EMbase, Clinical Guideline), reference lists and websites identified current versions of CPGs published since 2005. Read More

    Patterns of use of dry powder inhalers versus pressurized metered-dose inhalers devices in adult patients with chronic obstructive pulmonary disease or asthma: An observational comparative study.
    Chron Respir Dis 2017 Aug 24;14(3):309-320. Epub 2017 Feb 24.
    2 School of Pharmacy, Lebanese American University, Byblos, Lebanon.
    Numerous patients with chronic obstructive pulmonary disease (COPD) and asthma do not use inhaler devices properly, which can contribute to poor disease control. The objective of this study is to assess the technical and safety use of dry powder inhalers (DPIs) versus pressurized metered-dose inhalers (MDIs) in adult patients with COPD or asthma in Lebanon. A concurrent, prospective comparative observational study was conducted at one hospital and 15 community pharmacies in Lebanon. Read More

    Clinical-effectiveness of self-management interventions in chronic obstructive pulmonary disease: An overview of reviews.
    Chron Respir Dis 2017 Aug 24;14(3):276-288. Epub 2017 Feb 24.
    1 Health Technology Assessment, Health Information and Quality Authority, Dublin, Ireland.
    Self-management (SM) is defined as the provision of interventions to increase patients' skills and confidence, empowering the individual to take an active part in their disease management. There is uncertainty regarding the optimal format and the short- and long-term benefits of chronic obstructive pulmonary disease (COPD) SM interventions in adults. Therefore, a high-quality overview of reviews was updated to examine their clinical effectiveness. Read More

    Physical activity patterns and clusters in 1001 patients with COPD.
    Chron Respir Dis 2017 Aug 24;14(3):256-269. Epub 2017 Feb 24.
    1 Department of Research & Education, CIRO, Horn, The Netherlands.
    We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic and COPD-specific characteristics and, based on multiple physical activity measures, we identified clusters of patients. In total, 1001 patients with COPD (65% men; age, 67 years; forced expiratory volume in the first second [FEV1], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function and clinical data were assessed. Read More

    Experiences of patients undergoing pulmonary rehabilitation during an exacerbation of chronic respiratory disease.
    Chron Respir Dis 2017 Aug 9;14(3):298-308. Epub 2017 Mar 9.
    1 Centre for Exercise and Rehabilitation Science, Leicester Respiratory Biomedical Research Unit, Department of Respiratory Medicine, Glenfield Hospital, University Hospitals of Leicester, Leicester, UK.
    Chronic obstructive pulmonary disease (COPD) is characterized in the later stages by acute exacerbations that often require hospitalization. Pulmonary rehabilitation is recommended for patients with COPD to aid symptom control, improve quality of life and increase physical activity. We have previously reported a large intervention trial commenced during a hospital admission. Read More

    The Quebec Respiratory Health Education Network: Integrating a model of self-management education in COPD primary care.
    Chron Respir Dis 2017 Jan 1:1479972317723237. Epub 2017 Jan 1.
    5 Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
    The objective of this study is to evaluate whether a chronic obstructive pulmonary disease (COPD) self-management education program with coaching of a case manager improves patient-related outcomes and leads to practice changes in primary care. COPD patients from six family medicine clinics (FMCs) participated in a 1-year educational program offered by trained case managers who focused on treatment adherence, inhaler techniques, smoking cessation, and the use of an action plan for exacerbations. Health-care utilization, health-related quality of life (HRQL), treatment adherence, inhaler technique, and COPD knowledge were assessed at each visit with validated questionnaires. Read More

    Palliative care for respiratory disease: An education model of care.
    Chron Respir Dis 2017 Jan 1:1479972317721562. Epub 2017 Jan 1.
    Center to Advance Palliative Care, New York, NY, USA.
    That palliative care improves quality of life for seriously ill patients and their families is well known - but how can healthcare providers ensure that the palliative needs of all patients are being assessed and addressed? A growing number of curricula in core palliative care practices have been developed to ensure that clinicians from all specialties and disciplines have the necessary training to manage pain and symptoms and discuss care goals with patients and families. Through broad-based training in core palliative care skills, combined with referral to specialty palliative care for high-need patients, providers can improve quality of life for their patients with respiratory disease. Read More

    Breathlessness services as a new model of support for patients with respiratory disease.
    Chron Respir Dis 2017 Jan 1:1479972317721557. Epub 2017 Jan 1.
    2 University of Cambridge, Cambridge, United Kingdom.
    The complexity of breathlessness in advanced disease requires a diversity of measures ideally tailored to the individual patient needs. 'Breathlessness services' have been systematically developed and tested to provide specific interventions and support for patients and their carers. The aim of this article is (1) to identify and describe components of breathlessness services and (2) to describe the clinical model of one specific service in more detail. Read More

    Oral prednisolone for 4 days does not increase exercise tolerance in men with COPD.
    Chron Respir Dis 2017 Jan 1:1479972317721929. Epub 2017 Jan 1.
    1 Department of Respiratory Medicine, Hvidovre University Hospital, Hvidovre, Denmark.
    One of the primary objectives in management of chronic obstructive pulmonary disease (COPD) is preventing decrease in lung function and reducing the annual number of acute exacerbations of COPD (AECOPD). An oral course of systemic corticosteroids is a commonly used treatment in AECOPD. We hypothesize that this treatment also increases exercise performance and decreases muscle fatigue. Read More

    Assessing carer needs in chronic obstructive pulmonary disease.
    Chron Respir Dis 2017 Jan 1:1479972317719086. Epub 2017 Jan 1.
    School of Health Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.
    Informal carers play a key role in supporting patients with chronic obstructive pulmonary disease (COPD), particularly when disease is advanced. They also enable delivery of healthcare professional advice. There is a well-established impact of the caring role on carers in both the generic and COPD-specific literature. Read More

    Reliability and validity of the Chinese version of the Breathlessness Beliefs Questionnaire.
    Chron Respir Dis 2017 Jan 1:1479972317715551. Epub 2017 Jan 1.
    3 Peking Union Medical College Hospital, Beijing, China.
    The aim of this article is to evaluate the reliability and validity of the Chinese version of the Breathlessness Beliefs Questionnaire (BBQ) for use among patients with respiratory diseases in China. The BBQ is an instrument for assessing specific dyspnoea-related fears and may have predictive value for chronic obstructive pulmonary disease outcomes beyond general anxiety measures. This instrument has not previously been translated into Chinese or tested in mainland China. Read More

    Implementation of guideline-based therapy for chronic obstructive pulmonary disease: Differences between men and women veterans.
    Chron Respir Dis 2017 Nov 15;14(4):385-391. Epub 2017 Jun 15.
    7 Pain Research, Informatics, Multimorbidity, & Education Center, VA Connecticut Healthcare System, Department of Veterans Affairs, West Haven, CT, USA.
    Chronic obstructive pulmonary disease (COPD) is common among both men and women, and guidelines recommend the same therapy for both sexes. While previous studies have identified gender differences in other chronic disease management, few studies have examined how implementation of COPD guidelines differs between men and women. We performed a cross-sectional study of veterans admitted to Veterans Affairs (VA) hospitals for COPD during October 1, 2008, to September 30, 2011. Read More

    Improving care for advanced COPD through practice change: Experiences of participation in a Canadian spread collaborative.
    Chron Respir Dis 2017 Jan 1:1479972317712720. Epub 2017 Jan 1.
    3 Division of Respirology, Nova Scotia Health Authority/Dalhousie University, Halifax, Canada.
    Chronic obstructive pulmonary disease (COPD) is a leading cause of death, morbidity, and health-care spending. The Halifax, Nova Scotia-based INSPIRED COPD Outreach Program™ has proved highly beneficial for patients and the health-care system. With direct investment of <$1-million CAD, a pan-Canadian quality improvement collaborative (QIC) supported the spread of INSPIRED to 19 teams in the 10 Canadian provinces contingent upon participation in evaluation. Read More

    Changes in lower limb muscle function and muscle mass following exercise-based interventions in patients with chronic obstructive pulmonary disease: A review of the English-language literature.
    Chron Respir Dis 2017 Jan 1:1479972317709642. Epub 2017 Jan 1.
    1 REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
    Chronic obstructive pulmonary disease (COPD) patients often experience lower limb muscle dysfunction and wasting. Exercise-based training has potential to improve muscle function and mass, but literature on this topic is extensive and heterogeneous including numerous interventions and outcome measures. This review uses a detailed systematic approach to investigate the effect of this wide range of exercise-based interventions on muscle function and mass. Read More

    Patient and health care professional perspectives on using telehealth to deliver pulmonary rehabilitation.
    Chron Respir Dis 2017 Jan 1:1479972317709643. Epub 2017 Jan 1.
    1 Centre for Heart Lung Innovation, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
    The objective of this study was to identify the necessary features of pulmonary telerehabilitation (P-TR) from the perspectives of individuals living with chronic lung disease and health care professionals (HCPs) who deliver pulmonary rehabilitation (PR). Focus groups were carried out with patients ( n = 26) and HCPs ( n = 26) to elicit and explore their opinions about the critical elements of in-person PR and ideas for how these elements could be supported using technology. A questionnaire was used to assess technology use, PR experience, and general health status. Read More

    The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma.
    Chron Respir Dis 2017 Jan 1:1479972317709650. Epub 2017 Jan 1.
    1 Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, UK.
    The use of oral methotrexate for refractory eosinophilic asthma in a tertiary asthma referral centre, Glenfield Hospital, Leicester, was evaluated between January 2006 and December 2014. The patients ( n = 61) were carefully phenotyped at baseline with markers of airway inflammation. In addition, a structured oral methotrexate proforma was utilized to evaluate response to therapy and adverse events. Read More

    Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013.
    Chron Respir Dis 2017 Nov 30;14(4):377-384. Epub 2017 May 30.
    3 St. Lawrence Health System, Potsdam, NY, USA.
    Bronchiectasis is an incurable pulmonary disorder that is characterized pathologically by permanent bronchial dilatation and severe bronchial inflammation and clinically by chronic productive cough and recurrent infectious exacerbations; bronchiectasis often occurs in the presence of chronic obstructive pulmonary disease. It is widely believed that increasing use of high-resolution computed tomography has led to a marked rise in the number of persons with diagnosed bronchiectasis in current US clinical practice; up-to-date evidence, however, is lacking. Using a retrospective cohort design and health-care claims data (2009-2013), we estimated the prevalence of bronchiectasis (noncystic fibrosis)-based on narrow case-finding criteria-to be 139 cases per 100,000 persons, to be higher among women versus men (180 vs. Read More

    Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease.
    Chron Respir Dis 2017 Jan 1:1479972317709651. Epub 2017 Jan 1.
    1 Department of Research and Education, CIRO, Centre of expertise for chronic organ failure, Horn, the Netherlands.
    We aimed to investigate (1) the relationship between cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable chronic obstructive pulmonary disease (COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (COPD Assessment Test [CAT]) and St George's Respiratory Questionnaire-COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Read More

    The prevalence of chronic obstructive pulmonary disease in hookah smokers.
    Chron Respir Dis 2017 Jan 1:1479972317709652. Epub 2017 Jan 1.
    1 Department of Internal Medicine, Shohadaye Khalije Fars Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.
    Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Hookah smoking is growing worldwide and particularly in Iran. The aim of this study was to determine the prevalence of obstructive pulmonary dysfunction in hookah smokers. Read More

    Chronic obstructive pulmonary disease associated with increased risk of bipolar disorder.
    Chron Respir Dis 2017 May 1;14(2):151-160. Epub 2016 Jan 1.
    2 Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
    Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of chronic obstructive pulmonary disease (COPD). However, the relationship between COPD and subsequent bipolar disorder remains unclear. From January 1, 2000, we identified adult patients with COPD from the Taiwan National Health Insurance Research Database. Read More

    Cleaning and infection control of airway clearance devices used by CF patients.
    Chron Respir Dis 2017 Nov 17;14(4):370-376. Epub 2017 May 17.
    1 Pediatric Pulmonary Institute and CF Center, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
    Respiratory treatment for cystic fibrosis (CF) patients includes use of respiratory devices. Contamination of airway clearance devices has not been adequately explored. We aimed to determine whether airway clearance devices are contaminated after use and whether cleaning guidelines for nebulizers are as effective for airway clearance devices. Read More

    Uptake of telehealth implementation for COPD patients in a high-poverty, inner-city environment: A survey.
    Chron Respir Dis 2017 Jan 1:1479972317707653. Epub 2017 Jan 1.
    3 Lane Fox Respiratory Unit, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
    This study aimed to investigate computer and internet access and education attained in patients with chronic obstructive pulmonary disease (COPD) as potential barriers to implementation of telemedicine. We prospectively assessed 98 patients admitted with an acute exacerbation of COPD (mean age: 70.5 ± 9. Read More

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