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Angiol Sosud Khir 2019 ;25(1):32-38

Department of General Surgery, Ural State Medical University of the RF Ministry of Public Health, Ekaterinburg, Russia.

Analysed herein are one-year results of formation of arteriovenous fistulas in 109 patients with end-stage chronic renal failure, as well as therapeutic decision-making after angiosurgical counselling of 144 patients presenting with 'problem' permanent vascular accesses. The counselling and formation of arteriovenous fistulas were carried out in conditions of interdepartmental collaboration between outpatient centres dealing with haemodialysis and vascular surgeons specialized in ultrasound mapping of peripheral vessels and performing different variants of arteriovenous fistulas. The angiosurgical care was as close to the patient as possible. Read More

Clin J Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology Division, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.

In cancer patients, impairment of kidney function is not uncommon. Recently, the efficacy of the combination of gemcitabine and nab-paclitaxel for pancreatic ductal adenocarcinoma (PDAC) patients has been reported, however, there is no recommendation for dose and administration to patients undergoing hemodialysis (HD). A 66-year-old man began receiving HD for chronic renal failure 4 years previously. Read More

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 E 210th Street, Bronx, New York, NY, 10467, USA.

Objective: To determine all-cause mortality risk in patients with and without adrenal incidentaloma.

Methods: Retrospective cohort study of patients with CT abdomen performed within 24 h of emergency room presentation at an academic medical center from January 1, 2005, to December 31, 2009, without history of adrenal disease, adrenal lab testing, or cancer. Incidentaloma cohort identified by database query of imaging reports followed by manual review and matched to no-nodule controls at 3:1 on age ± 1 year and exam date ± 3 months. Read More

Kidney Int Rep 2019 Apr 4;4(4):582-593. Epub 2019 Feb 4.

Department of Medicine, Division of Nephrology, University of Wisconsin, Madison, Wisconsin, USA.

Introduction: Transplant glomerulopathy (TG) becomes increasingly prevalent in kidney transplant recipients over time, and it is strongly associated with allograft failure. To date, our prognostic biomarkers and understanding of the processes of immunologic injury in TG are limited.

Methods: This is a retrospective cohort analysis of kidney transplant recipients with TG (double contours of the glomerular basement membrane as defined by the chronic glomerulopathy score). Read More

Kidney Int Rep 2019 Apr 28;4(4):571-581. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Introduction: After dialysis-requiring acute kidney injury (AKI-D), recovery of sufficient kidney function to discontinue dialysis is an important clinical and patient-oriented outcome. Predicting the probability of recovery in individual patients is a common dilemma.

Methods: This cohort study examined all adult members of Kaiser Permanente Northern California who experienced AKI-D between January 2009 and September 2015 and had predicted inpatient mortality of <20%. Read More

Case Rep Nephrol 2019 12;2019:5390235. Epub 2019 Mar 12.

Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.

We describe a patient who had chronic lymphocytic leukaemia (CLL) Binet stage A at presentation with further evidence of disease at multiple sites but who initially required no treatment. However, several years later, her peripheral blood lymphocyte count started to increase, and soon after that she suffered an acute myocardial infarct (in the absence of coronary atheroma) together with proteinuric renal failure due to membranoproliferative glomerulonephritis. Her renal function improved markedly following anti-CLL chemotherapy. Read More

Emerg Med Int 2019 12;2019:2102390. Epub 2019 Mar 12.

Department of Renal Medicine, Changi General Hospital, Singapore, Singapore.

Introduction: It is not uncommon for patients without preceding history of kidney disease to present to the Emergency department with renal failure. The absence of prior medical records or renal imaging presents a diagnostic challenge. Elevated parathyroid hormone levels or echogenic contracted kidneys on ultrasound are known to point to a diagnosis of chronic kidney disease. Read More

Respir Care 2019 Apr 16. Epub 2019 Apr 16.

Department of Pulmonary and Critical Care Medicine, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.

Background: The Berlin definition of ARDS does not account for nonpulmonary organ failure, which is a major determinant of outcome. We examined whether an increasing severity of hypoxemia across the Berlin definition classifications also corresponded with evidence of multiple organ dysfunction on the day of ARDS onset. We also examined the representation of major etiologies for ARDS across the Berlin definition classifications. Read More

Contrib Nephrol 2019 16;198:124-134. Epub 2019 Apr 16.

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.

Background: The pathogenesis of anemia in chronic kidney disease (CKD) could be multifactorial. In recent animal studies, hepcidin knockout (KO) mice with adenine-induced CKD did not exhibit anemia and iron deficiency. Hepcidin has emerged as a major player in the development of anemia in CKD. Read More

Contrib Nephrol 2019 16;198:112-123. Epub 2019 Apr 16.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan,

Background: Hypoxia-inducible factor (HIF) stabilizers, also known as inhibitors of HIF prolyl hydroxylase domain (PHD) inhibitors enzymes, are novel small-molecule agents to treat renal anemia. They increase endogenous erythropoietin (EPO) production by stabilizing HIF. This review focuses on the mechanisms by which PHD inhibitors ameliorate anemia in chronic kidney disease (CKD) and summarizes the current clinical experience with and prospects for these drugs. Read More

N Engl J Med 2019 Apr 14. Epub 2019 Apr 14.

From the George Institute for Global Health, University of New South Wales Sydney (V.P., M.J.J., B.N., S. Bompoint), the Royal North Shore Hospital (V.P.), Concord Repatriation General Hospital (M.J.J.), and the Charles Perkins Centre, University of Sydney (B.N.), Sydney, and the Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW (C.P.) - all in Australia; Imperial College London (B.N.) and the Department of Renal Medicine, UCL Medical School (D.C.W.) - both in London; the Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (H.J.L.H., D.Z.); the Nephrology Division, NYU School of Medicine and NYU Langone Medical Center, New York (D.M.C.); Baim Institute for Clinical Research (D.M.C., C.P.C., B.M.B.), the Cardiovascular Division (C.P.C.) and the Renal Division and Department of Medicine (B.M.B), Brigham and Women's Hospital, and Harvard Medical School (B.M.B.) - all in Boston; Janssen Research and Development, Raritan, NJ (R.E., S. Bull, G.C., P.-L.C., Y.Y., G.M.); Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis (R.A.); the Department of Medicine, University of Chicago Medicine, Chicago (G.B.); the Division of Biostatistics, Department of Population Health Sciences, University of Utah, Salt Lake City (T.G.); the Division of Nephrology, University of British Columbia, Vancouver (A.L.), and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto (B.Z.) - all in Canada; the Renal Division, Peking University First Hospital, Beijing (H.Z.); and the Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.).

Background: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes.

Methods: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. Read More

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1246-1257

Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,College of Pharmaceutical Sciences & Chinese Medicine,Southwest University Chongqing 400715,China.

The aim of this paper was to observe the changes of EPO in rats with chronic renal failure and low immunity induced by adenine and to investigate the reversal effect of Yougui Yin(YGY)and exogenous EPO.SD rats were randomly divided into normal control group(n=20)and adenine-model group(n=90).The adenine-model group rats were given with adenine 150 mg·kg~(-1)for 14days by gavage administration,and then randomly divided into 8 groups as follows:model group(n=20),YGY groups(10,20,40 g·kg~(-1),10 in each group),rh EPO group(500,1 000,1 500 IU·kg~(-1),10 in each group),and Guilu Erxian Gao 10 g·kg~(-1)group(positive control group,n=10). Read More

J Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, Via Massarenti 9, 40100, Bologna, Italy.

Aldosterone is a mineralocorticoid hormone with a well-known effect on the renal tubule leading to water retention and potassium reabsorption. Other major effects of the hormone include the induction of proinflammatory activity that leads to progressive fibrotic damage of the target organs, heart and kidney. Blocking the aldosterone receptor therefore represents an important pharmacological strategy to avoid the clinical conditions deriving from heart failure (CHF) and chronic kidney disease (CKD). Read More

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e557-e559. Epub 2019 Mar 28.

Oman Medical College, Sohar, Oman.

Matrix stones are a rare form of urinary with a low mineral content. We report a 63-year-old female patient who presented to the Sohar Hospital, Sohar, Oman, in 2018 with unexplained left flank pain and constipation. She had a history of chronic renal failure (CRF) and had previously undergone haemodialysis (HD). Read More

Molecules 2019 Apr 16;24(8). Epub 2019 Apr 16.

Engineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, China.

Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified polysaccharide (LJP61A) on renal function using an adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. Read More

Iran J Kidney Dis 2019 Mar;13(2):98-104

Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, USA.

Introduction: Chronic kidney disease (CKD) promotes hypertrophy and fibrosis in heart, and increases the risk of cardiovascular mortality. Ferric citrate is a dietary phosphate binder used to control hyperphosphatemia in CKD patients. It has been shown to raise iron stores, improve anemia and secondary hyperparathyroidism, and decrease vascular calcification in CKD patients. Read More

Clin J Am Soc Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology.

Background And Objectives: Intravenous iron therapy for chronic anemia management is largely driven by dosing protocols that differ in intensity with respect to dosing approach (, dose, frequency, and duration). Little is known about the safety of these protocols.

Design, Setting, Participants, & Measurements: Using clinical data from a large United States dialysis provider linked to health care utilization data from Medicare, we constructed a cohort of patients with ESKD aged ≥65 years who initiated and continued center-based hemodialysis for ≥90 days between 2009 and 2012, and initiated at least one of the five common intravenous iron administration strategies; ranked by intensity (the amount of iron given at moderate-to-high iron indices), the order of strategies was 3 (least intensive), 2 (less intensive), 1 (reference), 4 (more intensive), and 5 (most intensive). Read More

J Hosp Med 2019 Apr 8;14:E1-E9. Epub 2019 Apr 8.

Department of Medicine, Hofstra-Northwell School of Medicine, Hempstead, New York.

Background: Differences between hospital-presenting sepsis (HPS) and emergency department-presenting sepsis (EDPS) are not well described.

Objectives: We aimed to (1) quantify the prevalence of HPS versus EDPS cases and outcomes; (2) compare HPS versus EDPS characteristics at presentation; (3) compare HPS versus EDPS in process and patient outcomes; and (4) estimate risk differences in patient outcomes attributable to initial resuscitation disparities.

Design: Retrospective consecutive-sample cohort. Read More

A A Pract 2019 Apr 11. Epub 2019 Apr 11.

Vascular Surgery, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.

We present a patient who was admitted for carotid endarterectomy due to tight carotid stenosis and recent amaurosis fugax. His medical history included significant coronary artery disease with stable angina pectoris, hypertension with wide pulse pressure, chronic renal failure, and anemia. During preparation for surgery, the patient developed type 2 myocardial infarction with prolonged chest pain, ST depressions on electrocardiogram, and significant troponin elevations. Read More

Intern Med J 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

Background: Elevated D-dimer levels have been associated with poor outcomes in patients with cardiovascular disease. We sought to study this association in elderly patients with chronic heart failure (CHF).

Methods: We analyzed 1355 elderly patients who were admitted with CHF. Read More

Nephrol Dial Transplant 2019 Apr 15. Epub 2019 Apr 15.

Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY, USA.

Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of cardiovascular disease (CVD) in ESKD is reduced after KT; however, it still remains the leading cause of premature patient and allograft loss, as well as a source of significant morbidity and healthcare costs. All major phenotypes of CVD including coronary artery disease, heart failure, valvular heart disease, arrhythmias and pulmonary hypertension are represented in the KT recipient population. Read More

J Family Med Prim Care 2019 Feb;8(2):426-431

Department of Paediatrics, Government Doon Medical College, Dehradoon, Uttarakhand, India.

Background: Currently, in developing countries like India, there is a paradigm shift in the mortality patterns of elderly from communicable to noncommunicable diseases.

Objective: This study is aimed at providing an insight on mortality patterns of elderly patients within a 2-year period in a tertiary hospital, All India Institute of Medical Sciences (AIIMS), Rishikesh, India.

Materials And Methods: This study is a retrospective review of mortality patterns of elderly patients from March 2016 to March 2018 occurring in the Department of General Medicine, in AIIMS, Rishikesh, India. Read More

J Pediatr Urol 2019 Feb 27. Epub 2019 Feb 27.

Oslo University Hospital, Department of Pediatric Surgery, Norway.

Introduction: A posterior urethral valve (PUV) may lead to extravasation of urine, resulting in prenatal ascites and/or perirenal urinoma. Extravasation has been presumed to act as a pop-off mechanism, preserving renal function, but previous reports addressing this presumption have been inconclusive.

Aim Of Study: The present study compares renal function in patients with PUV with and without extravasation. Read More

J Cardiol 2019 Apr 11. Epub 2019 Apr 11.

Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan. Electronic address:

Background: Angiotensin receptor and neprilysin inhibition (ARNI) has been shown to reduce cardiovascular mortality by 20% as compared with enalapril in a randomized controlled trial. However, there is a paucity of real-world data on the effects of ARNI in heart failure patients with reduced ejection fraction (HFrEF), especially those with concurrent renal impairment or hypotension.

Methods: Between 2016 and 2017, we recruited 466 HFrEF patients treated with sacubitril/valsartan (Group A) and 466 patients managed with standard HF treatment without ARNI (Group B) in a HF referral center. Read More

Nephrol Ther 2019 Apr;15 Suppl 1:S21-S26

Unité de contrôle et de prévention du risque infectieux, service de microbiologie, groupe hospitalier universitaire, hôpital Avicenne, Paris Seine Saint-Denis, 125, rue de Stalingrad, 93000 Bobigny, France; UFR-SMBH, université Paris XIII, Paris Sorbonne, 125, rue de Stalingrad, 93000 Bobigny, France. Electronic address:

The patient followed in nephrology ward for a glomerulopathy is exposed throughout his illness, into the hospital as in the community, at a high risk of bacterial, viral and more and more frequently fungal infections. At each stage of his illness, given the comorbidities associated with his renal pathology, the immunosuppressive treatments administered and the chronic haemodialysis and renal transplantation in the event of progressive disease, the nephrological patient requires specific management. Prevention consists on one hand to limit as much as possible infectious risks in the community by improving its vaccination coverage before, during and after the renal transplant and by limiting urinary infections which can worsen the underlying disease. Read More

Nephrol Ther 2019 Apr;15 Suppl 1:S1-S5

Inserm, Paris Cardiovascular Centre (Parcc), 56, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:

Necrotizing and crescentic rapidly progressive glomerulonephritis or crescentic glomerulonephritis is one of the severest forms of acquired glomerular diseases with significant mortality. Risk of end-stage renal failure at 5 years is near 30%, with a number of patients developing chronic kidney disease. Currently, autoimmune crescentic glomerulonephritides are treated with broad-spectrum immunosuppression inducing remission of the injury in the majority of patients. Read More

Am Heart J 2019 Mar 21;212:101-112. Epub 2019 Mar 21.

Duke Clinical Research Institute, Durham, NC; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC.

Heart failure (HF) outcomes are especially poor in high-risk patients with certain comorbidities including diabetes mellitus (DM), chronic kidney disease (CKD), and chronic obstructive pulmonary disease (COPD). Whether early specialty or primary care provider (PCP) follow-up after HF discharge affects outcomes in high-risk patients is unknown.

Methods: We analyzed patients discharged from a Get With The Guidelines HF-participating hospital from 2007-2012 with linked Medicare claims to investigate the association of medical specialist visit within 14 days of discharge stratified by comorbidity with the primary outcome of 90-day HF readmission. Read More

J Cachexia Sarcopenia Muscle 2019 Apr 12. Epub 2019 Apr 12.

Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California, Irvine, School of Medicine, Orange, Irvine, CA, USA.

Weight loss and homeostatic disturbances of both energy and protein balances are characteristics of several illnesses including cancer, heart failure, and chronic kidney disease (CKD). Different definitions have been used to describe this deleterious process. The term protein-energy wasting (PEW) has been proposed for CKD patients by the International Society of Renal Nutrition and Metabolism. Read More

Heliyon 2019 Mar 28;5(3):e01365. Epub 2019 Mar 28.

Faculty of Sciences, University of Lomé, Togo.

Management of chronic renal failure is exceedingly expensive. Despite of encouraging experimental outcomes, there is a lack of potent nephroprotective drugable molecules in a clinics or market. To develop a nephroprotective phytomedicine, the present study was designed to do a literature survey on reported phytochemical and biological analysis of and to carry out chemoprofiling, in-vitro antioxidant and ex-vivo nephroprotective capacity of the title plant. Read More

Clin Kidney J 2019 Apr 19;12(2):294-299. Epub 2018 Sep 19.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: A sub-analysis of a Phase III study was conducted to identify factors that might predict increased ferritin levels during long-term sucroferric oxyhydroxide (SO) treatment in hemodialysis patients.

Methods: The open-label, multicenter, Phase III study assessed the efficacy and safety of SO 750-3000 mg/day for 52 weeks in Japanese patients with chronic renal failure and hyperphosphatemia. A total of 125 of 161 patients from the Phase III trial, and who had data for ferritin levels after 28 weeks of SO treatment, were evaluated. Read More

Cardiovasc Revasc Med 2019 Mar 29. Epub 2019 Mar 29.

Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America.

We describe an interesting case of a 71 years old fragile female, with progressive shortness of breath on exertion and ankle swelling, cardiac failure NYHA class III. She also had chest irradiation due to Hodgkin's disease many years before, previous surgical aortic valve replacement using bioprosthetic stent-less Freestyle #25 mm valve (Medtronic, Inc) in 2000 for severe aortic stenosis, history of cardiac arrest in 2012 and angioplasty to ostial RCA, PCI to ostial RCA in 2014, CABG (RA graft to RCA) in 2014 (RCA intra-stent restenosis with refractory ischemia), anemia requiring regular transfusions, bronchiectasis and chronic kidney disease. Because of the great comorbidities, STS 4. Read More

Pediatr Transplant 2019 Apr 11:e13407. Epub 2019 Apr 11.

Department of Paediatrics, Western University, London, Ontario, Canada.

Objectives: MMA is associated with chronic tubulointerstitial nephritis and a progressive decline in GFR. Optimal management of these children is uncertain. Our objectives were to document the pre-, peri-, and post-transplant course of all children with MMA who underwent liver or combined liver-kidney transplant in our centers. Read More

Spine (Phila Pa 1976) 2019 Apr 5. Epub 2019 Apr 5.

Spine Surgery, Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242.

MINI: The study investigates the association between preoperative chronic opioid therapy on long-term outcomes (reoperations, ED visits, postoperative opioid use, and adverse events)in patients undergoing primary cervical spine arthrodesis using a commercial claims dataset.

Study Design: Retrospective, observational.

Objective: To define the impact of preoperative chronic opioid therapy (COT) on outcomes following cervical spine fusions. Read More

Eur J Clin Pharmacol 2019 Apr 10. Epub 2019 Apr 10.

Pharmacovigilance and Pharmacoepidemiology Centre, Pharmacology Department, CHU Rennes, 2, rue Henri Le Guilloux, 35000, Rennes, France.

Background: The hepatotoxicity of acetaminophen is recognised worldwide. Unfavourable prognoses relating to overdose include liver transplantation and/or death. Several hepatotoxicity risk factors (HRFs) should motivate the adjustment of acetaminophen daily intake (to < 4 g/day): advanced age, weight < 50 kg, malnutrition, chronic alcoholism, chronic hepatitis B and C and HIV infection, severe chronic renal failure and hepatocellular insufficiency. Read More

Ann Card Anaesth 2019 Apr-Jun;22(2):187-193

Divisions of Cardio-Thoracic Surgery, Amrita Institute of Medical Sciences and Research Center, Amrita Viswa Vidyapeetham (Amrita University), Kochi, Kerala, India.

Background: The female gender is considered as a risk factor for morbidity and mortality after coronary artery bypass grafting (CABG).

Aim: In this analysis, we assessed the impact of female gender on early outcome after CABG.

Study Design: This is a retrospective analysis of data from our center situated in South India. Read More

Pediatr Nephrol 2019 Apr 9. Epub 2019 Apr 9.

John's Hopkins Children's Center, Baltimore, MD, USA.

Background: Peritoneal dialysis (PD) is the preferred chronic dialysis modality amongst pediatric patients. Peritonitis is a devastating complication of PD. Adult data demonstrates early onset peritonitis (EP) is associated with higher rates of subsequent peritonitis and technique failure. Read More

Exp Clin Transplant 2019 Apr 9. Epub 2019 Apr 9.

From the Department of Emergency, Baskent University Faculty of Medicine, Ankara, Turkey.

Objectives: Infection-associated emergency department use in renal transplant recipients has been increasing as solid-organ transplant has become a more common treatment method for chronic kidney failure. Platelet-to-lymphocyte ratio has been demonstrated to be significantly elevated in nosocomial infections in patients treated at intensive care units and is positively correlated with duration of hospital stay. In this study, we aimed to determine whether the platelet-to-lymphocyte ratio could be used as an indicator of infection in renal transplant patients presenting to emergency departments. Read More

Rheumatol Int 2019 Apr 9. Epub 2019 Apr 9.

Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Izmir Katip Celebi University, Karabaglar, 35360, Izmir, Turkey.

The mechanisms underlying new bone formation in individuals with axial spondyloarthritis (axSpA) remain unclear; however, low levels of sclerostin (SOST) may be associated with development of syndesmophytes in those with ankylosing spondylitis (AS). Expression of fibroblast growth factor-23 (FGF-23), another osteocyte factor, is high in those with osteoporosis and chronic renal failure, but levels in those with axSpA are unknown. To evaluate serum FGF-23 and SOST levels in axSpA patients, and to assess their relationship with inflammation and structural damage. Read More

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

General Medical Unit, Alfred Health, Melbourne, Victoria, Australia.

Background: Extreme heat is a public health priority in Australia with the health effects of cold poorly studied. A record-breaking cold winter prompted an institutional investigation into the epidemiology and outcomes of hypothermic presentations.

Method: This was a retrospective cohort observational study of hypothermic emergency presentations between 7 July 2009 and 1 September 2016 with a temperature of ≤35°C. Read More

Transpl Int 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands.

In 1983 the first combined liver and kidney transplantation (CLKT) was performed by Margreiter et al and the first CLKT from a living related donor was carried out in Turkey in 1992. The indications for CLKT can be divided into three categories: I) end-stage liver disease with chronic kidney failure, II) end-stage liver disease with acute kidney failure, and III) metabolic disorders. This article is protected by copyright. Read More

Clin Rheumatol 2019 Apr 8. Epub 2019 Apr 8.

Division of Rheumatology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, P.O. Bertsham, Johannesburg, 2013, South Africa.

Introduction: To investigate the prevalence and spectrum of comorbidities in South Africans with systemic lupus erythematosus (SLE).

Patients And Methods: A nested case-control study of a known alive group (AG) and deceased group (DG) of 200 and 40 patients, respectively, matched for age and sex, attending a tertiary Lupus Clinic. Comorbidities that were documented included, but not restricted to, those listed in the Charlson comorbidity index (CCI). Read More

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Bron, France.

Background: Liver lesions of hemolytic uremic syndrome due to Shiga-toxin-producing Escherichia coli (STEC-HUS) are uncommon.

Case-diagnosis/treatment: We report three observations of severe STEC-HUS with delayed hepatic involvement. They presented with multiple organ failure and received eculizumab; 15 days after the onset of STEC-HUS, cholestasis appeared and cytolysis worsened. Read More

Ann Transl Med 2019 Feb;7(4):64

Department of Orthopaedic Surgery, Lenox Hill Hospital, Northwell Health, New York, NY, USA.

Background: Fibromyalgia is a disease primarily characterized by chronic widespread pain and associated symptoms of fatigue, mild cognitive impairment, and sleep disturbance. The condition affects 1% to 6% of the general population in the United States and is more commonly diagnosed in women (2:1 ratio). There is evidence to suggest that fibromyalgia patients may be more at risk of postoperative complications. Read More

Clin J Am Soc Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University School of Medicine, Baltimore, Maryland;

Am J Infect Control 2019 Apr 6. Epub 2019 Apr 6.

Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, Réanimation des Détresses Respiratoires et des Infections Sévères, Marseille, France; Aix-Marseille Université, School of Medicine - La Timone Medical Campus, CEReSS - Health Service Research and Quality of Life Center, Marseille, France.

Background: The link between bacterial resistance and prognosis remains controversial. Predominant pathogen causing ventilator-associated pneumonia (VAP) is Pseudomonas aeruginosa (Pa), which has increasingly become multidrug resistant (MDR). The aim of this study was to evaluate the relationship between MDR VAP Pa episodes and 30-day mortality. Read More

Dtsch Arztebl Int 2019 Mar;116(9):149-158

Background: 10-20% of hospitalized patients develop acute kidney injury (AKI)/acute renal failure during their hospital stay. The mortality of nosocomial AKI is approximately 30%.

Methods: This review is based on relevant publications retrieved by a search in multiple databases (PubMed and Uptodate), archives, and pertinent medical journals. Read More

J Knee Surg 2019 Apr 8. Epub 2019 Apr 8.

Department of Orthopedics, Duke University School of Medicine, Durham, North Carolina.

With a growing prevalence for chronic renal failure, arthroplasty surgeons will find it more likely to have dialysis dependent patients present for knee replacement. Previous retrospective studies using a matched cohort of patients have reported worse perioperative outcomes for dialysis-dependent patients. However, many of these studies failed to control for pertinent confounders. Read More