114,683 results match your criteria Chronic Renal Failure


[Establishment of rat model of cardiorenal syndrome by transabdominal subtotal nephrectomy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):447-452

Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

To evaluate the changes of rat renal function and cardiac function after transabdominal subtotal nephrectomy (STNx) and provide an ideal animal model for the study of chronic kidney disease (CKD) and cardiorenal syndrome (CRS). The SD rats (male, 5-6 weeks) were randomly divided into Sham group (10) and STNx group (10). The rats from Sham group underwent sham surgery, and the right nephrectomy plus the 2/3 left kidney artery ligation through abdominal incision were performed in the rats from STNx group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.013DOI Listing
February 2019

Adherence assessment practices in haemodialysis settings: a qualitative exploration of nurses and pharmacists' perspectives.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

School of Healthcare, University of Leeds, Leeds, United Kingdom.

Aims And Objectives: To explore clinician assessment of patient adherence, and identify strategies to improve adherence assessment practices in haemodialysis settings.

Background: Patients with chronic kidney disease undergoing haemodialysis are typically prescribed complex regimens; as such, they are at high risk of medication nonadherence. Current clinical practices focus on prescribing medications, however, little attention is paid to measuring and ensuring patient adherence to their prescribed treatments. Read More

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http://dx.doi.org/10.1111/jocn.14821DOI Listing
February 2019

Differences in Management of Coronary Artery Disease in Patients With Medicare Advantage vs Traditional Fee-for-Service Medicare Among Cardiology Practices.

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Cardiovascular Division, Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri.

Importance: One-third of Medicare beneficiaries are enrolled in Medicare Advantage (MA), Medicare's private plan option. Medicare Advantage incentivizes performance on evidence-based care, but limited information exists using reliable clinical data to determine whether this translates into better quality for patients with coronary artery disease (CAD) enrolled in MA compared with those enrolled in traditional fee-for-service (FFS) Medicare.

Objective: To determine differences in evidence-based secondary prevention treatments and intermediate outcomes among patients with CAD enrolled in MA vs FFS Medicare. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.0007DOI Listing
February 2019

Resveratrol exerts dose-dependent anti-fibrotic or pro-fibrotic effects in kidneys: A potential risk to individuals with impaired kidney function.

Phytomedicine 2018 Dec 17;57:223-235. Epub 2018 Dec 17.

Key Laboratory of Transplant Engineering and Immunology, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China; Center for Metabolic and Vascular Biology, School for Nutrition and Health Promotion, College of Health Solutions, Arizona State University, Scottsdale, AZ, United States. Electronic address:

Background: Renal fibrosis is the pathological feature of chronic kidney disease (CKD) which leads to end-stage renal disease (ESRD) and renal failure. Resveratrol [3,5,4'-trihydroxy-trans-stilbene (RSV)] has shown benefits for metabolic diseases and anti-cancer therapy, but its potential risk on renal health has not been fully evaluated.

Purpose: To investigate the global effects of RSV on renal fibrosis in human tubular epithelial cell (TEC) line HK-2, and in mice with unilateral ureteral obstruction (UUO). Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.024DOI Listing
December 2018

Adherence to fluid resuscitation guidelines and outcomes in patients with septic shock: Reassessing the "one-size-fits-all" approach.

J Crit Care 2019 Feb 5;51:94-98. Epub 2019 Feb 5.

Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Objective: The Surviving Sepsis Campaign and Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock Management Bundle (SEP-1) recommend rapid crystalloid infusion (≥30 mL/kg) for patients with sepsis-induced hypoperfusion or septic shock. We aimed to assess compliance with this recommendation, factors associated with non-compliance, and how compliance relates to mortality.

Design: Retrospective, observational study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.006DOI Listing
February 2019

Patient expectations and experiences of remote monitoring for chronic diseases: Systematic review and thematic synthesis of qualitative studies.

Int J Med Inform 2019 Apr 29;124:78-85. Epub 2019 Jan 29.

Department of Medicine, University of Otago Christchurch, 8140, New Zealand; Department of Nephrology, Canterbury District Health Board, Christchurch, New Zealand.

Objectives: To describe the range of patients' beliefs, attitudes, expectations, and experiences of remote monitoring for chronic conditions across different healthcare contexts and populations.

Design: We searched MEDLINE, Embase, PsychINFO, and CINAHL, Google Scholar, and reference lists of related studies through to July 2017. Thematic synthesis was used to analyse the findings of the primary studies. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2019.01.013DOI Listing

Video-assisted thoracic surgery for pleuroperitoneal communication.

Surg Case Rep 2019 Feb 19;5(1):34. Epub 2019 Feb 19.

Department of Thoracic Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Hydrothorax due to pleuroperitoneal communication (PPC) is a rare complication of continuous ambulatory peritoneal dialysis (CAPD). Approximately 50% of the patients need to convert to hemodialysis.

Case Presentation: A 65-year-old man with chronic renal failure due to membranoproliferative glomerulonephritis underwent CAPD. Read More

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http://dx.doi.org/10.1186/s40792-019-0595-8DOI Listing
February 2019

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.

Sci Rep 2019 Feb 19;9(1):2256. Epub 2019 Feb 19.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Rho-kinase (ROCK) activation in hepatic stellate cells (HSC) is a key mechanism promoting liver fibrosis and portal hypertension (PTH). Specific delivery of ROCK-inhibitor Y-27632 (Y27) to HSC targeting mannose-6-phosphate-receptors reduces portal pressure and fibrogenesis. In decompensated cirrhosis, presence of ascites is associated with reduced renal perfusion. Read More

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http://www.nature.com/articles/s41598-019-38678-5
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http://dx.doi.org/10.1038/s41598-019-38678-5DOI Listing
February 2019
1 Read

Impact of renal dysfunction on the management and outcome of acute heart failure: results from the French prospective, multicentre, DeFSSICA survey.

BMJ Open 2019 Jan 15;9(1):e022776. Epub 2019 Jan 15.

Emergency Department and RESCUe Network, Lucien Hussel Hospital, Vienne, France.

Objectives: Cardiorenal syndrome (CRS) is the combination of acute heart failure syndrome (AHF) and renal dysfunction (creatinine clearance (CrCl) ≤60 mL/min). Real-life data were used to compare the management and outcome of AHF with and without renal dysfunction.

Design: Prospective, multicentre. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340446PMC
January 2019

Lanthanum carbonate for hyperphosphatemia in patients with advanced CKD and patients receiving dialysis.

Expert Rev Endocrinol Metab 2009 Jul;4(4):307-316

b Manchester Institute of Nephrology and Transplantation, The Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK.

Reduced renal excretion of phosphate leads to hyperphosphatemia, which is prevalent in patients with end-stage renal disease, and is associated with increased morbidity and mortality. Dialysis alone is unable to adequately remove the ingested phosphate contained in food. It is therefore usually necessary to supplement food with drugs that reduce the intestinal absorption of dietary phosphate in order to control serum phosphate. Read More

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http://dx.doi.org/10.1586/eem.09.11DOI Listing

Hydrogen Sulfide Protects Hyperhomocysteinemia-Induced Renal Damage by Modulation of Caveolin and eNOS Interaction.

Sci Rep 2019 Feb 18;9(1):2223. Epub 2019 Feb 18.

Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, 40292, USA.

The accumulation of homocysteine (Hcy) during chronic kidney failure (CKD) can exert toxic effects on the glomeruli and tubulo-interstitial region. Among the potential mechanisms, the formation of highly reactive metabolite, Hcy thiolactone, is known to modify proteins by N-homocysteinylation, leading to protein degradation, stress and impaired function. Previous studies documented impaired nitric oxide production and altered caveolin expression in hyperhomocysteinemia (HHcy), leading to endothelial dysfunction. Read More

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http://dx.doi.org/10.1038/s41598-018-38467-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379383PMC
February 2019

Predictors of in-hospital adverse events after endovascular aortic aneurysm repair.

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Vascular and Endovascular Research Center, Johns Hopkins University, Baltimore, Md. Electronic address:

Background: Endovascular aneurysm repair (EVAR) offered outstanding survival benefit but at the expense of cost, periodic radiographic monitoring, and higher reinterventions rates. Perioperative complications, although rare, can occur after EVAR, contributing to longer hospitalization, higher cost, and significant comorbidity and mortality. Therefore, the aim of this study was to identify the predictors of in-hospital events (IHEs) after elective EVAR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07415214183255
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http://dx.doi.org/10.1016/j.jvs.2018.10.093DOI Listing
February 2019
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Frequencies of Common Infectious Organisms Causing Chronic Diarrhea in Renal Transplant Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):212-215

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Objectives: Gastrointestinal complications are common in kidney transplant patients, with the most frequent being diarrhea (60%). Chronic diarrhea affects the patient's quality of life, causes fatigue and weight loss and malabsorption, increases the number of hospitalizations, increases serum creatinine levels, and causes alterations in immunosuppressive drug levels. Diarrhea is also associated with an increased risk of graft failure and death. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P69DOI Listing
January 2019

Acute Respiratory Failure in Renal Transplant Recipients: A Single Center Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):172-174

From the Pulmonary Medicine, Baskent University, Adana, Turkey.

Objectives: We evaluated the frequency and cause of acute respiratory failure in renal transplant recipients.

Materials And Methods: Our single-center retrospective observational study included consecutive renal transplant recipients who were admitted to an intensive care unit for acute respiratory failure between 2011 and 2017. Acute respiratory failure was defined as oxygen saturation < 92% or partial pressure of oxygen in arterial blood < 60 mm Hg on room air and/or requirement of noninvasive or invasive mechanical ventilation. Read More

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http://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=10.60
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http://dx.doi.org/10.6002/ect.MESOT2018.P49DOI Listing
January 2019
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Kidney Transplant in Pediatric Patient With Heart Failure: Case Report.

Exp Clin Transplant 2019 Jan;17(Suppl 1):153-155

From the Department of Transplantation, Servicios de Salud Del Estado de Queretaro, Hospital General de Querétaro, Querétaro, México.

Chronic kidney disease is defined as irreversible and progressive damage of the kidney. Chronicity is defined by the presence of renal dysfunction for at least 3 months, and renal dysfunction is defined through combinations of investigation (abnormal radiologic findings, abnormal urine or abnormal biochemistry reflecting renal dysfunction) and/or documentation of glomerular filtration rate below 60 mL/min/1.73 m². Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P23DOI Listing
January 2019

Disaster preparedness for earthquakes in hemodialysis units in Gyeongju and Pohang, South Korea.

Kidney Res Clin Pract 2019 Feb 18. Epub 2019 Feb 18.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

In 2016 and 2017, there were earthquakes greater than 5.0 in magnitude on the Korean Peninsula, which has previously been considered an earthquake-free zone. Patients with chronic kidney disease are particularly vulnerable to earthquakes, as the term "renal disaster" suggests. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0058DOI Listing
February 2019

Autophagy and immunological aberrations in systemic lupus erythematosus.

Eur J Immunol 2019 Feb 18. Epub 2019 Feb 18.

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034, People's Republic of China.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, in which immune defects can occur at multiple points of the cascading auto-aggressive immune reactions, resulting in a striking heterogeneity of clinical presentations. The clinical manifestations of such autoimmune response can be severe:-common manifestations symptoms include rash and renal inflammation progressing to kidney failure. Autophagy, the cellular "self-digestion" process, is a key factor in the interplay between innate and adaptive immunity. Read More

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http://doi.wiley.com/10.1002/eji.201847679
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http://dx.doi.org/10.1002/eji.201847679DOI Listing
February 2019
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Interference Rendering Capillary Electrophoresis of Serum Proteins Uninterpretable.

Clin Lab 2019 Jan;65(1)

Background: The authors report a clinical case where biological interference rendered the electrophoretic trace of serum proteins obtained by capillary electrophoresis as uninterpretable.

Methods: Electrophoresis of serum proteins and immunotyping immunoassay were performed on Capillary 2 Flex Piercing® Sebia.

Results: A 72-year-old male patient was hospitalized in the clinical hematology department for deep lymphadenopathies with hepatocellular failure. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180634DOI Listing
January 2019

Left Ventricular Structure in Patients With Mild-to-Moderate CKD-a Magnetic Resonance Imaging Study.

Kidney Int Rep 2019 Feb 11;4(2):267-274. Epub 2018 Oct 11.

Department of Nephrology and Hypertension, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

Introduction: The high burden of left ventricular (LV) abnormalities in patients with advanced chronic kidney disease (CKD) is well established. However, less is known about the prevalence, patterns, and determinants of LV abnormalities in patients with early CKD.

Methods: We examined LV structure in 290 patients with a median estimated glomerular filtration rate (eGFR) of 51 ml/min per 1. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365352PMC
February 2019

Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir in Patients With Hepatitis C Virus Genotype 1 or 4 Infection and Advanced Kidney Disease.

Kidney Int Rep 2019 Feb 9;4(2):257-266. Epub 2018 Oct 9.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Introduction: Hepatitis C virus (HCV) infection is common in patients with end-stage renal disease. We investigated the safety and efficacy of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) ± dasabuvir (DSV) ± ribavirin (RBV) in 2 phase 3, open-label, multicenter studies in patients with stage 4 or 5 chronic kidney disease (CKD).

Methods: RUBY-I, Cohort 2 enrolled treatment-naïve or -experienced patients with HCV genotype (GT) 1a or 1b infection, with or without cirrhosis. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365406PMC
February 2019

Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients.

Case Rep Surg 2019 15;2019:4136214. Epub 2019 Jan 15.

Department of General Surgery, Boston Children's Hospital, 300 Longwood Ave, Fegan 3, Boston MA 20115, USA.

Introduction: There are no reported survivors of gastroschisis with complete liver herniation. We describe a case report of two patients, one of whom survived.

Case #1: The patient was born with gastroschisis and herniation of the entire liver. Read More

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http://dx.doi.org/10.1155/2019/4136214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350565PMC
January 2019

Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension.

Oxid Med Cell Longev 2019 10;2019:8912768. Epub 2019 Jan 10.

Department of Experimental Medicine, Section of Pharmacology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Cardiovascular diseases frequently coexist with chronic kidney disease that constitutes a major determinant of outcome in patients with heart failure. Dysfunction of both organs is related to chronic inflammation, endothelial dysfunction, oxidative stress, and fibrosis. Widespread expression of serine protease DPP4 that degrades varieties of substrates suggests its involvement in numerous physiological processes. Read More

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http://dx.doi.org/10.1155/2019/8912768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350609PMC
January 2019

A Multicenter Large-Scale Retrospective Analysis of the Correlation between Body Mass Index and All-Cause Mortality in Patients with Type 2 diabetes Mellitus: A Seven-Year Real-World Study.

Endocr Res 2019 Feb 18:1-7. Epub 2019 Feb 18.

a Department of Intensive Care Unit , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , Zhejiang , P.R. China.

Aims: To investigate the association between body mass index (BMI) and all-cause mortality in patients with type 2 diabetes mellitus (T2DM) and to determine any sex-specific differences in this association.

Methods: We retrospectively enrolled patients with T2DM and investigated the annual death data for seven years starting from 2010. All-cause mortality was calculated using Life Tables analysis. Read More

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http://dx.doi.org/10.1080/07435800.2019.1573826DOI Listing
February 2019

Glomerular filtration rate in patients with moderate to severe psoriasis.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Psoriasis could be associated to comorbidities that can affect kidney function, including diabetes mellitus, arterial hypertension and hyperuricaemia. Chronic kidney disease (CKD) affects up to 10.4% of patients with psoriasis , and it is a risk factor for renal failure, cardiovascular diseases and overall mortality. Read More

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http://doi.wiley.com/10.1111/jdv.15506
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http://dx.doi.org/10.1111/jdv.15506DOI Listing
February 2019
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Molecular assessment of rejection and injury in lung transplant biopsies.

J Heart Lung Transplant 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Alberta Transplant Applied Genomics Center, Edmonton, Alberta, Canada. Electronic address:

Background: Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces.

Methods: We prospectively studied whether microarray assessment of single TBB pieces could identify disease states and reduce the amount of tissue required for diagnosis. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1317DOI Listing
February 2019

Development of the LC-MS/MS method for determining the p-cresol level in plasma.

J Pharm Biomed Anal 2019 Jan 31;167:149-154. Epub 2019 Jan 31.

Department of Bioanalysis and Drugs Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland. Electronic address:

p-Cresol is a protein-bound uremic retention solute that originates in the intestine through bacterial metabolism and accumulates throughout the body in case of kidney failure. To date, there has been no method to analyze unconjugated p-cresol concentration in the blood with a limit of detection lower than 75 pg. Thus, the aim of this study was to develop and validate a novel liquid chromatography-tandem mass spectrometry method for the determination of unconjugated p-cresol in plasma with a lower detection limit than what has been determined using previously described methods. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.01.041DOI Listing
January 2019
1 Read

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Baylor Scott and White, Dallas, Texas.

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.058DOI Listing
February 2019
1 Read

Spondylodiscitis in end-stage renal disease: a systematic review.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18824DOI Listing
February 2019
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[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 02 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019
1 Read

Digoxin-specific Fab and therapeutic plasma exchange for digitalis intoxication and renal failure: A case report.

Am J Emerg Med 2019 Jan 22. Epub 2019 Jan 22.

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Manzoni 56, Rozzano, MI, Italy.

Treatment of chronic digitalis intoxication includes suspension of drug intake, which may be sufficient in case of mild manifestations, and supportive measures. Severe bradycardia requires the administration of atropine or isoproterenol; placement of a temporary pacemaker may be required in case of absent response to pharmacological therapy. Severe and life-threatening manifestations should be treated with digoxin-specific fragment antigen binding antibodies (Fab). Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.038DOI Listing
January 2019
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Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative stress has long been thought to play a role in triggering podocyte damage; however, the underlying mechanism remains poorly understood. Here we show that the Wnt/β-catenin pathway is involved in mediating oxidative stress-induced podocyte dysfunction. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.032DOI Listing
February 2019

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

In type 2 cardiorenal syndrome, chronic heart failure is thought to cause or promote chronic kidney disease; however, the underlying mechanisms remain poorly understood. We investigated the role of Wnt signaling in heart and kidney injury in a mouse model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC). At 8 weeks after TAC, cardiac hypertrophy, inflammation, and fibrosis were prominent, and echocardiography confirmed impaired cardiac function. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.021DOI Listing
February 2019
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(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease.

J Card Fail 2019 Feb 12. Epub 2019 Feb 12.

Department of Cardiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. Electronic address:

Background: The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle region peptide (HRP), on chronic kidney disease (CKD)-associated heart failure.

Methods And Results: CKD was induced in C57BL/6J mice by 5/6 nephrectomy. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.02.009DOI Listing
February 2019
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Factors that impact kidney function during open and endovascular reconstruction of aortic aneurysms.

Cir Cir 2019 ;87(2):170-175

Dirección de Cirugía, Sección de Angiología, Cirugía Vascular y Terapia Endovascular, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México.

Background: To analyze the factors that influence the deterioration of postoperative renal function in patients undergoing open or endovascular aortic reconstruction, and the impact on survival.

Method: Retrospective review of patients who underwent invasive treatment was conducted. Demographics, laboratory data, clinical, intraoperative and postoperative variables were recorded; renal function was determined, Fisher's exact test was used to find associations and Kaplan Meier analysis to estimate survival. Read More

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http://dx.doi.org/10.24875/CIRU.18000448DOI Listing
January 2019
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The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.

Curr Med Res Opin 2019 Feb 15:1-13. Epub 2019 Feb 15.

e Division of Nephrology , St. Michael's Hospital , Toronto , Ontario , Canada.

Background: Heart failure (HF) and chronic kidney disease (CKD) are responsible for substantial morbidity and mortality in individuals with type 2 diabetes (T2D).

Methods: This review discusses the significance of these comorbidities of T2D and current options for managing them, with a focus on sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Based on a focused literature search of cardiovascular outcomes trials (CVOTs), this review assessed the effects of SGLT-2 inhibitors in individuals with T2D with or without established cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1080/03007995.2019.1576479DOI Listing
February 2019
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Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy.

Rheumatol Ther 2019 Feb 14. Epub 2019 Feb 14.

Nephrology Division, University Hospital Limerick, Graduate Entry Medical School, Health Research Institute, University of Limerick, Limerick, Ireland.

Introduction: The rate of adverse renal events has been shown to be higher in patients treated with lesinurad plus a xanthine-oxidase inhibitor (XOI) than in patients treated only with a XOI. We reassessed the risks for various adverse renal events from a different perspective and devised a hypothesis to explain the results.

Methods: We used data from phase 3 trials that were publicly available from the full prescribing information document and estimated the relative risk and the number needed to treat for increased serum creatinine (sCri), renal failure, and renal lithiasis. Read More

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http://dx.doi.org/10.1007/s40744-019-0143-9DOI Listing
February 2019
1 Read

Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study.

Clin Res Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiovascular Sciences, Clinical Sciences Wing, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK.

Background: Proenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart failure. We investigated the prognostic utility of PENK in heart failure with preserved ejection fraction (HFpEF), and its relationship to renal function, Body Mass Index (BMI), and imaging measures of diastolic dysfunction.

Methods: In this multicentre study, PENK was measured in 522 HFpEF patients (ejection fraction > 50%, 253 male, mean age 76. Read More

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http://dx.doi.org/10.1007/s00392-019-01424-yDOI Listing
February 2019
2 Reads

Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C Related Decompensated Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):4-12. Epub 2018 Mar 6.

Institute of Liver, Gastroenterology, & Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

Background: Sofosbuvir (SOF), a direct acting antiviral, has revolutionized the treatment of chronic Hepatitis C Virus (HCV) infection. However, data is scarce about efficacy of SOF plus Ribavarin (RBV) in Indian patients with decompensated cirrhosis. We evaluated the efficacy of SOF plus RBV in decompensated cirrhosis, and compared the outcome with compensated cirrhosis and non-cirrhotics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183004
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http://dx.doi.org/10.1016/j.jceh.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363947PMC
March 2018
4 Reads

Urinary Potassium Excretion and Progression of Chronic Kidney Disease.

Clin J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea;

Background And Objectives: Data on whether low or high urinary potassium excretion is associated with poor kidney outcome have been conflicting. The aim of this study was to clarify the association between urinary potassium excretion and CKD progression.

Design, Setting, Participants, & Measurements: We investigated the relationship between lower urinary potassium excretion and CKD progression and compared three urinary potassium indices among 1821 patients from the Korean Cohort Study for Outcome in Patients with CKD. Read More

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http://dx.doi.org/10.2215/CJN.07820618DOI Listing
February 2019
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Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Objective: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control.

Research Design And Methods: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. Read More

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http://dx.doi.org/10.2337/dc18-1936DOI Listing
February 2019
1 Read

Endothelin-1 levels and cardiovascular events.

Trends Cardiovasc Med 2019 Feb 1. Epub 2019 Feb 1.

Vascular Research Laboratory, Providence VA Medical Center, 830 Chalkstone Ave., Office 158L, Providence, RI, USA; Division of Cardiology, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.

Circulating plasma levels of endothelin-1 and related peptides generated during the synthesis of endothelin-1 from its precursor molecule pre-proendothelin-1 have been widely studied as potential risk markers for cardiovascular events. The associations of endothelin-1 with aging, blood pressure, lung function, and chronic kidney disease have been described, as have relations between endothelin-1 levels and evidence of cardiac remodeling, including increased left atrial diameter and increased left ventricular mass. Endothelin-1 has been studied as a predictor of and prognostic marker in coronary artery disease, myocardial infarction, and heart failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10501738183023
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http://dx.doi.org/10.1016/j.tcm.2019.01.007DOI Listing
February 2019
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Prevalence and predictors of self care practices among hypertensive patients at Jimma University Specialized Hospital, Southwest Ethiopia: cross-sectional study.

BMC Res Notes 2019 Feb 14;12(1):86. Epub 2019 Feb 14.

Pharmacy Department, Jimma University, Jimma, Ethiopia.

Objective: Hypertension is a major risk factor and precursor of myocardial infarction, chronic kidney disease, heart failure and premature death. These vascular events increased costs of hypertension management. Self-care Practices were recommended to control blood pressure among hypertensive patients. Read More

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http://dx.doi.org/10.1186/s13104-019-4125-3DOI Listing
February 2019
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Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

BMC Nephrol 2019 Feb 14;20(1):53. Epub 2019 Feb 14.

Department of Pathology, Division of Renal and Transplant Pathology, Ohio State University Wexner Medical Center, M018 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1239-8DOI Listing
February 2019
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Risk of subsequent health disorders among living kidney donors.

Medicine (Baltimore) 2019 Feb;98(7):e14494

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University.

Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens.We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902150-0005
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http://dx.doi.org/10.1097/MD.0000000000014494DOI Listing
February 2019
2 Reads

Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease

Turk J Med Sci 2019 Feb 11;49(1):327-335. Epub 2019 Feb 11.

Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD).

Materials And Methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Read More

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http://dx.doi.org/10.3906/sag-1809-43DOI Listing
February 2019
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Lung Ultrasound B-lines Occurrence in Relation to Left Ventricular Function and Hydration Status in Hemodialysis Patients.

Medicina (Kaunas) 2019 Feb 12;55(2). Epub 2019 Feb 12.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, Poland.

Background And Objective: Reliable assessment of the fluid status in hemodialysis (HD) patients is often difficult. A lung ultrasound with an assessment of the B-lines ("lung comets" (LCs)) number is a novel hydration status measure. However, the occurrence of left ventricular dysfunction may have a significant effect on pulmonary congestion and further modulate the LC number. Read More

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http://dx.doi.org/10.3390/medicina55020045DOI Listing
February 2019
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[The unusual couple: a clinical case of coexistence between aHUS and Fabry's disease].

G Ital Nefrol 2019 Feb;36(1)

Professore Ordinario di Nefrologia, Università degli Studi della Campania, Luigi Vanvitelli.

Atypical hemolytic-uremic syndrome (aHUS) is a rare, potentially lethal (1-4) systemic disorder, capable of affecting both adults and children, causing thrombotic microangiopathy (TMA) (5) that leads to the formation of thrombus within small blood vessels with multiple organ failure. The pathogenesis of the aHUS is part of a sort of chronic and uncontrolled activation of the complement system by genetic mutation of some proteins usually responsible for its self-regulation (6,7). Today, the rapid diagnosis of the disease and the timely start of treatment with eculizumab, improve outcomes of renal failure, stroke and heart attack (8-10). Read More

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February 2019
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[Atrial fibrillation in severe and end stage renal disease: from oral anticoagulation therapy to percutaneous left atrial appendage occlusion].

G Ital Nefrol 2019 Feb;36(1)

Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Non-valvular atrial fibrillation (AF) is the most frequent arrhythmia in the general population and its prevalence increases with age. The prevalence and incidence of AF is high in patients with chronic kidney failure (CKD). The most important complication associated with AF, both in the general population and in that with CKD, is thromboembolic stroke. Read More

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February 2019
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Metabolic Acidosis Due To Pyroglutamic Acid.

Eur J Case Rep Intern Med 2018 24;5(10):000949. Epub 2018 Oct 24.

Internal Medicine Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Metabolic acidosis is a common clinical disturbance due to increased plasma acidity caused by a primary decrease in serum HCO3- concentration. It is classified as normal or high anion gap metabolic acidosis. High anion gap metabolic acidosis can result from either a decrease in unmeasured cations (K, Ca2, Mg2) or an increase in unmeasured anions (PO, albumin). Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/949
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http://dx.doi.org/10.12890/2018_000949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346886PMC
October 2018
2 Reads

Study of Vitamin D Deficiency among the Apparently Healthy Population in Jashore, Bangladesh.

Mymensingh Med J 2019 Jan;28(1):214-221

Dr Goutam Kumar Acherjya, Junior Consultant (Medicine), Upazila Health Complex, Bagherpara, Jashore, Bangladesh; E-mail:

Globally Vitamin D deficiency is a burning issue for the last two decades. Though the very high prevalence of hypovitaminosis D is worldwide even in the South-East Asia but there is very limited data in Bangladesh. This observational study was designed to assess the status of Vitamin D deficiency among the clinically apparent healthy population in the district of Jessore, Bangladesh from January 2017 to June 2017. Read More

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January 2019
2 Reads