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Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Dynamic, Clinical and Health Psychology, "Sapienza" University, 00185 Rome, Italy.

Women with endometriosis often suffer from genito-pelvic pain. The objective of the present study was to analyze the relationship between cognitive and psycho-emotional factors and sexual functioning of women with endometriosis, comparing women with and without endometriosis. A total of 87 women with endometriosis (EG) and 100 women without endometriosis (CG) completed a socio-demographic questionnaire; the short-form of McGill Pain Questionnaire (SF-MPQ); the Female Sexual Functioning Index (FSFI); the Sexual Distress Scale (SDS); the Symptoms Checklist (SCL-90-R); the Toronto Alexithymia Scale (TAS-20); the Positive and Negative Affects Scale (PANAS); the Sexual Dysfunctional Belief Questionnaire (SDBQ); the Sexual Modes Questionnaire (SMQ); and the Questionnaire of Cognitive Schema Activation in Sexual Context (QCSASC). Read More

Int J Mol Sci 2022 Apr 25;23(9). Epub 2022 Apr 25.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Neurogenic inflammation and central sensitization play a role in chronic prostatitis/chronic pelvic pain syndrome. We explore the molecular effects of low-intensity shock wave therapy (Li-ESWT) on central sensitization in a capsaicin-induced prostatitis rat model. Male Sprague-Dawley rats underwent intraprostatic capsaicin (10 mM, 0. Read More

Addict Sci Clin Pract 2022 May 13;17(1):27. Epub 2022 May 13.

Hatanpää Health Center, Tampere, Finland.

Background: Subcutaneously retained needle fragments in people who inject drugs (PWIDs) are a possible cause of local symptoms, most commonly pain and infections. It remains unknown how common retained needle fragments are among PWIDs.

Case Presentation: A young PWID consulted a primary care physician due to chronic left-sided groin pain. Read More

BMC Surg 2022 May 13;22(1):175. Epub 2022 May 13.

Gynecology Department, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.

Background: The most common complications of myomectomy are intraoperative hemorrhage and postoperative adhesion. The key point to overcome this problem is to improve suture quality. However, to date, there is still no consensus on the optimal method of uterine repair. Read More

Andrologia 2022 May 12:e14455. Epub 2022 May 12.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a poorly understood disease. Accumulating evidence suggests that autoimmune dysfunction is involved in the development of CP/CPPS. Interleukin-17 (IL-17) is associated with the occurrence and development of several chronic autoimmune inflammatory diseases. Read More

ACS Omega 2022 May 19;7(17):14856-14866. Epub 2022 Apr 19.

Centre of Biomedical Research (CBMR), SGPGIMS Campus, Lucknow-226014, Uttar Pradesh, India.

Endometriosis (EM) is a hormone-dependent gynecological disease associated with chronic pelvic pain and altered immuno-inflammatory processes. It shares some cancer-like characteristics such as increased proline biosynthesis and activated glutaminolysis. Both proline and glutamine are interconvertible metabolically, and studies have shown their roles in cancer cell metabolic reprogramming, redox homeostasis, occurrence/development of endometrial carcinoma, and its further progression toward the malignant state. Read More

FASEB J 2022 May;36 Suppl 1

Ponce Health Sciences University-Ponce Research Institute, Ponce, PR.

Introduction: Endometriosis is a complex gynecological disorder characterized by the ectopic growth of endometrial tissue. Symptoms of endometriosis are known to impair the quality of life of patients, among these symptoms are dysmenorrhea, chronic pelvic pain, and gastrointestinal (GI) issues. These GI issues are one of the common reasons for misdiagnosis with irritable bowel syndrome (IBS), a pain syndrome characterized by abdominal pain, painful bowel movements, diarrhea, and constipation, all of which are often present in endometriosis and persist even after treatment. Read More

Clin Exp Immunol 2022 May;207(3):360-369

Department of Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China.

Endometriosis is a chronic inflammatory disorder resulting in pelvic pain and infertility. The role of T helper 17 (Th17) cells in endometriosis remains elusive. In this study, through detecting CXCR3, CCR4, CCR10, CCR6, interleukin-17 Receptor E (IL-17RE), and CD27, RORγt-and-IL-17A-expressing Th17 cells were distinguished and sorted from peritoneal fluid (PF) of patients with stage III and IV endometriosis. Read More

J Am Coll Radiol 2022 May;19(5S):S137-S155

Associate Chair for Ambulatory Care and Specialty Chair, University of Michigan, Ann Arbor, Michigan.

Pelvic floor disorders including pelvic organ prolapse (POP), urinary dysfunction, defecatory dysfunction, and complications after pelvic floor surgery are relatively common in the female population. Imaging tests are obtained when the initial clinical evaluation is thought to be incomplete or inconclusive or demonstrates findings that are discordant with patients' symptoms. An integrated imaging approach is optimal to evaluate the complex anatomy and dynamic functionality of the pelvic floor. Read More

J Am Coll Radiol 2022 May;19(5S):S114-S120

Specialty Chair, University of Michigan, Ann Arbor, Michigan.

Palpable scrotal abnormalities are caused by a variety of disorders, ranging from indolent benign conditions to aggressive tumors, and infectious and vascular processes. In these patients the diagnostic workup typically begins with a complete clinical, history, and physical examinations, including analysis of risk factors. If imaging is required, ultrasound examination is the diagnostic modality of choice. Read More

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Department of Urogynecology, TriHealth, Cincinnati, OH.

Background: Patients undergoing vaginal hysterectomy with native tissue pelvic reconstruction typically have low pain levels overall in the postoperative period. Notwithstanding, pain control immediately following surgery may be more challenging and a barrier to same-day discharge. Intrarectal diazepam has been utilized for acute and chronic pelvic pain and has a pharmacokinetic profile ideal for intermittent use. Read More

Front Med (Lausanne) 2022 25;9:878815. Epub 2022 Apr 25.

Department of Gynecology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: Hysterectomy is one of the most frequently performed operations worldwide. However, postoperative complications and body image changes may induce psychological distress after hysterectomy. The study aimed to evaluate the effect of psychological intervention on pelvic floor function and psychological outcomes following hysterectomy among patients with benign indications. Read More

Int Urogynecol J 2022 May 11. Epub 2022 May 11.

Menopause and Osteoporosis Unit, San Rossore Clinical Center, Pisa, Italy.

Introduction And Hypothesis: The Vaginal Health Index Score (VHIS) and vulvodynia swab tests are used to assess vaginal health and vulvodynia. However, few studies have used these tests in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). IC/BPS is a chronic, debilitating disorder, characterised by urinary frequency, urinary urgency and pelvic pain. Read More

Clin Nucl Med 2022 May 11. Epub 2022 May 11.

From the Department of Radiology, Hospital of the University of Pennsylvania.

Abstract: Prostatic calculi are common and usually asymptomatic calcified stones frequently found incidentally in imaging or during the evaluation of benign prostatic hyperplasia. Those associated with chronic prostatitis can lead to bacterial colonization, inflammation, and blockage of secretory ducts, resulting in pelvic pain and lower urinary tract symptoms. Although PET tracers such as 18F-NaF and 18F-FDG have been used to assess metastatic and benign bone disorders, their comparative avidity in the domain of extraosseous and prostate calcification remains to be fully explored. Read More

BMC Womens Health 2022 May 10;22(1):146. Epub 2022 May 10.

Department of Obstetrics and Gynecology, University of Messina, Messina, Italy.

Background: To evaluate the effects of a combined oral contraceptive containing 1.5 mg 17b-estradiol (E2) and 2.5 mg nomegestrol acetate (NOMAC) or 2 mg/daily dienogest (DNG) oral progestin on endometriosis-associated chronic pelvic pain (CPP) and on the quality of life (QoL) and sexual function, by a randomized study design. Read More

Female Pelvic Med Reconstr Surg 2022 May 5. Epub 2022 May 5.

Departments of Obstetrics & Gynecology.

Objectives: The aim of this study was to determine the relationship between opioid prescriptions and number of chronic pain conditions in women with interstitial cystitis (IC).

Methods: This was a cross-sectional study. Women diagnosed with IC based on International Classification of Diseases, Ninth Revision/Tenth Revision codes over an 11-year period (2010-2020) were identified from electronic medical records. Read More

Urology 2022 May 6. Epub 2022 May 6.

Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Clinical Urology, Weil Cornell Medicine -Qatar, Doha, Qatar.

Objective: to evaluate the effectiveness of UPOINT based multimodal treatment on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and determine factors that could be associated with clinical improvement.

Methods: A retrospective study was conducted in Doha, Qatar including patients with CP/CPPS from the Middle East and North Africa. The UPOINT phenotyping system was used to classify patients and guide their multimodal therapy. Read More

Phys Med Rehabil Clin N Am 2022 May;33(2):475-487

Anesthesiology and Critical Care, Duke University, 2080 Duke University Road, Durham, NC 27708, USA.

For patients with chronic pain or cancer-related pain, the most common indication for sympathetic block is to control visceral pain arising from malignancies or other alterations of the abdominal and pelvic viscera. When it is recalcitrant to conservative care, or if the patient is intolerant to pharmacotherapy, consideration of sympathetic blocks or neurolytic procedures is considered. Potential advantages of a neurolytic procedure, compared with spinal and epidural anesthetic infusions, include cost savings and avoidance of hardware. Read More

Phys Med Rehabil Clin N Am 2022 May;33(2):379-407

Department of Anesthesiology, Division of Pain Medicine, University of California, San Diego, CA, USA; Koman Family Outpatient Pavilion, Center for Pain Medicine, 9400 Campus Point Drive, MC 7328, La Jolla, CA 92037, USA.

Interventional pain procedures offer treatments for chronic pain conditions refractory to conservative measures. Neuromodulation, including peripheral nerve stimulation (PNS), applies electrical stimuli to neural structures to treat pain. Here we review the literature on PNS for various chronic pain conditions including neuropathic pain, postamputation pain, musculoskeletal pain, migraine, and pelvic pain. Read More

Reprod Fertil 2022 Apr 17;3(2):R34-R41. Epub 2022 Mar 17.

Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.

Endometriosis is a chronic, multisystemic disease often presenting with significant phenotypic variation amongst patients. The impact of race/ethnicity on the prevalence of endometriosis, as well as disease presentation, is a question of interest which has been explored for the last century. This narrative review explores the historical perspective of endometriosis and race/ethnicity as well as the evidence available to date. Read More

Urol Int 2022 May 5:1-9. Epub 2022 May 5.

School of Engineering and Mathematical Sciences, University of Western Australia, Perth, Washington, Australia.

Background: The posterior fornix syndrome (PFS) was first described in 1993 as a predictably occurring group of symptoms: chronic pelvic pain (CPP), urge, frequency, nocturia, emptying difficulties/urinary retention, caused by uterosacral ligament (USL) laxity, and cured by repair thereof.

Summary: Our hypothesis was that non-Hunner's interstitial cystitis (IC) and PFS are substantially equivalent conditions. The primary objective was to determine if there was a causal relationship between IC and pelvic organ prolapse (POP). Read More

Tech Coloproctol 2022 May 5. Epub 2022 May 5.

Department of Surgery, Proctos Clinic, Bilthoven, The Netherlands.

Background: A chronic anal fissure is a common, painful condition with great impact on daily life. The exact pathogenesis has not been fully elucidated and treatment varies. A large percentage of patients experience pelvic floor dysfunction (dyssynergia and increased pelvic floor muscle tone). Read More

Prostate Int 2022 Jun 11;10(2):92-95. Epub 2022 Mar 11.

Department of Urology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea.

Background: We investigated the association between moderate-to-severe prostatitis-like symptoms and the predictors of benign prostatic hyperplasia (BPH) progression.

Methods: Men who underwent health checkups were analyzed. We classified symptoms as "moderate to severe" if the pain score according to the National Institutes of Health-Chronic Prostatitis Symptoms Index was ≥8 and predictors of the progression of BPH were defined as having a prostate-specific antigen (PSA) ≥1. Read More

Prostate Int 2022 Jun 29;10(2):96-107. Epub 2022 Mar 29.

Department of Urology, Kashihara, Nara, 634-8522, Japan.

The microbiome in various organs involves a vast network that plays a key role in the health and wellness of the human body. With recent advances in biological technologies such as high-throughput sequencing, transcriptomics, and metabolomics, it appears that the microbial signature varies dynamically among individuals, creating various roles in metabolism, local and systemic inflammation, and host immunity. Urinary and genital organs, including the prostate, seminal vesicles, and urinary bladder, are reservoirs of several bacterial, viral, and fungal communities. Read More

Asian J Urol 2022 Apr 11;9(2):139-145. Epub 2021 Sep 11.

San Filippo Neri Hospital, Department of Urology, Rome, Italy.

Objective: To assess the efficacy and safety of a treatment regimen based on rectal administration of Boswellia resin extract and propolis derived polyphenols in patients with type IIIa and type IIIb chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS).

Methods: Patients with type IIIa and type IIIb CP/CPPS received one rectal suppository a day for 15 days per month for 3 consecutive months. Participants were evaluated with National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Scores (IPSS), International Index of Erectile Function (IIEF), four-glass test, uroflowmetry, and prostate-specific antigen assessments at baseline and at Week 4, and Week 12. Read More

J Sex Med 2022 May 1. Epub 2022 May 1.

Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, MA, USA; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Background: Sexual minority (lesbian, bisexual, mostly heterosexual) young women face many sexual and reproductive health disparities, but there is scant information on their experiences of chronic pelvic pain, including an absence of information on prevalence, treatment, and outcomes.

Aim: The purpose of this study was to describe the characteristics of chronic pelvic pain experiences of young women by sexual orientation identity and gender of sexual partners.

Methods: The analytical sample consisted of a nationwide sample of 6,150 U. Read More

Vasa 2022 May;51(3):119-120

Specialist Practice Angiology Brado - Erbel, Heidelberg, Germany.

Cureus 2022 Apr 25;14(4):e24481. Epub 2022 Apr 25.

Urology, University Hospital Virgen de la Arrixaca, Murcia, ESP.

Purpose Chronic pelvic pain syndrome (CPPS) is permanent pelvic pain of unknown etiology. Current theories suggest a multifactorial origin for CPPS, including urinary pathologies, psychosocial factors, prostate inflammation, infection, central sensitization of the nervous system, and muscular contractures or fibrosis. As there are no defined treatment protocols for CPPS, a multimodal approach is recommended. Read More

Exp Ther Med 2022 Jun 8;23(6):382. Epub 2022 Apr 8.

Department of Andrology, Ganzhou Municipal Hospital, Ganzhou, Jiangxi 341000, P.R. China.

Chronic pelvic pain syndrome (CPPS) and chronic prostatitis (CP) is difficult to distinguish from each other, herein termed CP/CPPS. The present study aimed at gaining further insight into the change in extracellular vesicles (EVs) in the prostatic fluid of males with CPPS. From December 2019 to November 2020, after clinical screening, 24 patients with CPPS without obvious urinary symptoms and 13 healthy male participants were included. Read More

Nihon Yakurigaku Zasshi 2022 ;157(3):164-167

Department of Pharmacology and Toxicology, Dokkyo medical university.

Men with benign prostatic hyperplasia (BPH) often experience symptoms of overactive bladder (OAB), and bladder outlet obstruction (BOO) is one of cause of BPH. It has been suggested that bladder myogenic microcontractions or micromotions may partly contribute to the development of urgency (bladder sensory (afferent) hypersensitivity) in OAB related to BOO. We have investigated the direct effects of drugs (β3-adrenoceptor agonists, α1-adrenoceptor antagonists, PDE type5 inhibitors) on the bladder afferent function in BOO rats. Read More