Search Our Scientific Publications & Authors

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Neurological Sciences, University of Vermont, United States.

High expression of vascular endothelial growth factor (VEGF) is associated with immature angiogenesis within the urinary bladder wall and bladder afferent nerve sensitization leading to visceral hyperalgesia and pelvic pain. Research suggests a shift in VEGF alternative splice variant (VEGF-Aa, VEGF-Ab) expression with several pathologies (e.g. Read More

Endocr Rev 2019 Apr 17. Epub 2019 Apr 17.

Departments of Obstetrics and Gynecology, Northwestern University, Chicago, IL.

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. Read More

Unfallchirurg 2019 Apr 16. Epub 2019 Apr 16.

Departments of Surgery, Neurology and Sports Medicine, Maxima Medical Center, De Run 4600, 7777, 5500 MB, Veldhoven, The Netherlands.

Young individuals with chronic exercise-induced lower leg pain (ELP) who have normal compartmental muscle pressures and normal imaging occasionally suffer from a nerve entrapment syndrome. These patients have consistently undergone a variety of diagnostic tests and often futile therapies prior to arriving at the correct diagnosis. Awareness among traumatologists regarding these nerve entities is low. Read More

J R Army Med Corps 2019 Apr 16. Epub 2019 Apr 16.

Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre Headley Court, Epsom, UK.

Introduction: Chronic exertional compartment syndrome (CECS) presents with pain during exercise, most commonly within the anterior compartment of the lower limb. A diagnosis is classically made from a typical history and the measurement of intramuscular compartmental pressure (IMCP) testing. Improved, more specific diagnostic criteria for IMCP testing allow clinicians to now be more certain of a diagnosis of CECS. Read More

Rev Bras Ginecol Obstet 2019 Mar 16;41(3):170-175. Epub 2019 Apr 16.

University of Siena, Siena, Italy.

Objective:  Endometriosis is a complex disease, and pain is an important component of the syndrome. One of the most used methods to assess pain is the visual analogue scale (VAS). The aim of the present research was to study the pain experienced by patients who referred to our unit for endometriosis, using the VAS to understand the variables that could influence it. Read More

Neurourol Urodyn 2019 Apr 15. Epub 2019 Apr 15.

Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Aims: Central sensitization playsimportant roles in cyclophosphamide (CYP)-induced cystitis. In addition, as a visceral pain, CYP-induced chronic pain shares common pathophysiological mechanisms with neuropathic pain. Previous studies demonstrated that neuregulin-1 (Nrg1)-ErbB signaling contributes to neuropathic pain, but whether and how this signaling influences mechanical allodynia in CYP-induced cystitis is unclear. Read More

MedEdPORTAL 2016 Dec 31;12:10527. Epub 2016 Dec 31.

Branch Chief, Chronic Viral Diseases Branch, Centers for Disease Control and Prevention.

Introduction: Over a million adults in the U.S. are affected by chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). Read More

Neural Plast 2019 11;2019:2098083. Epub 2019 Mar 11.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Read More

Prof Inferm 2018 Oct-Dec;71(4):209-220

Coordinatore Didattico CdL in Infermieristica M, Sapienza Università di Roma, sede AO S. Camillo-Forlanini, Roma.

Objective: The paper provides a description of available measurement tools which are able to adequately assess acute chronic pain in Down Syndrome (DS) patients, regardless of their age and cognitive impairment.

Methods: Papers referring to DS patients were sought using different databases, such as PubMed, CINAHL, Scopus, Web of Science (ISI) and Cochrane, with no limit of time and published up to October 2017. All validated tools applicable to DS patients were included in the search, which consisted of papers published both in English and Italian. Read More

Unfallchirurg 2019 Apr 12. Epub 2019 Apr 12.

Máxima Medical Center, De Run 4600, P.O. Box 7777, 5500 MB, Veldhoven, The Netherlands.

Exercise-induced leg pain (ELP) and tightness may be caused by a chronic exertional compartment syndrome (CECS). Although CECS can develop in any muscle compartment, most individuals suffer from an anterior tibial muscle CECS (ant-CECS). Typically, a patient with ant-CECS experiences discomfort toward the end of sports activity or in the hours thereafter. Read More

Int Urol Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

Purpose: In patients with loin pain hematuria syndrome (LPHS), a response to percutaneous renal hilar blockade (RHB) and a multidisciplinary team (MDT) evaluation predicts patient's potential renal auto-transplantation (RAT) success.

Methods: A pain assessment was performed using a 0-10 numeric pain rating scale prior to a percutaneous RHB under CT guidance. If the pain score was reduced > 50% immediately after the RHB, patients were evaluated for RAT by a MDT. Read More

Neuromodulation 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.

Introduction: Apart from the clinical efficacy of high frequency spinal cord stimulation at 10 kHz, the underlying mechanism of action remains unclear. In parallel with spinal or segmental theories, supraspinal hypotheses have been recently proposed. In order to unveil hidden altered brain connectome patterns, a resting state functional magnetic resonance imaging (rsfMRI) protocol was performed in subjects routinely treated for back and/or leg pain with high-frequency spinal cord stimulation (HF-SCS) HF-SCS at 10 kHz. Read More

PLoS One 2019 11;14(4):e0215201. Epub 2019 Apr 11.

Clinics Hospital, Department of Urology, University of de Sao Paulo Medical School, Sao Paulo, Brazil.

Introduction: Interstitial Cystitis (IC) is a chronic condition diagnosed based on the presence of symptoms, such as suprapubic/ pelvic pain, pressure or discomfort in association with urgency and increased urinary frequency. Confusable diseases must be excluded. However, there is no objective test or marker to establish the presence of the disease. Read More

Front Immunol 2019 22;10:546. Epub 2019 Mar 22.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial peptides released by neutrophils. NETs were initially described in the context of pathogen defense but are also involved in autoimmune-mediated skin diseases. Read More

Clin Toxicol (Phila) 2019 Apr 9:1-11. Epub 2019 Apr 9.

a Department of Emergency Medicine , University of California Davis Medical Center , Sacramento , CA , USA.

Introduction: Cannabis smoking can result in elevation of heart rate and blood pressure immediately after use, possibly from sympathetic nervous system stimulation and parasympathetic nervous system inhibition. Vascular inflammation, platelet activation, and carboxyhemoglobin generation have also been proposed as potential side effects of cannabis smoking. As such, an association between cannabis use and acute coronary syndrome has been postulated. Read More

J Tradit Complement Med 2019 Apr 1;9(2):163-167. Epub 2018 Jun 1.

Chulabhorn International College of Medicine, Thammasat University, Pathumthani, 12121, Thailand.

Myofascial pain syndrome (MPS) is a chronic pain disorder which causes musculoskeletal pain and inflammation in the body's soft tissues. Thai Traditional Medicine uses hot herbal compresses as analgesic and anti-inflammatory treatment. There are no scientifically validated follow-up studies after treatment using hot herbal compresses. Read More

J Thorac Dis 2019 Feb;11(2):418-426

Department of Thoracic Surgery, Kliniken Essen-Mitte, Essen, Germany.

Background: Thoracotomy leads to acute and chronic post-thoracotomy pain (CPTP). The purpose of this study was to investigate the effect of magnesium sulphate (MgSO) administered perioperatively on acute postoperative and CPTP syndrome.

Methods: One hundred patients were enrolled in this prospective, observational study. Read More

Georgian Med News 2019 Feb(287):20-25

Kharkiv National Medical University, Ukraine.

The purpose of the study is examination the dynamics of antioxidant defense indicators and lipoperoxidation processes in women with pregnancy termination different periods. 227 pregnant women were examined, 190 of them had clinical signs of premature birth in the gestation period of 23-36 weeks. Formation of clinical groups was carried out depending on the term of pregnancy in the form of premature and timely birth. Read More

Sex Med 2019 Apr 3. Epub 2019 Apr 3.

BC Women's Center for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada; Women's Health Research Institute, Vancouver, British Columbia, Canada; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada; BC Centre for Vulvar Health, Vancouver, British Columbia, Canada. Electronic address:

Introduction: Pelvic pain and vulvar pain are common conditions in women. In this study, we sought to characterize the clinical picture of patients with concurrent pelvic pain and provoked vestibulodynia (PVD).

Aim: To analyze the association between sexual/clinical characteristics and a diagnosis of PVD among women with pelvic pain. Read More

Transfus Apher Sci 2019 Mar 19. Epub 2019 Mar 19.

Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA.

Objective: Stiff person syndrome (SPS) is commonly associated with antibodies directed against 65-kDa glutamic acid decarboxylase (GAD65). Therapeutic Plasma Exchange (TPE) has been used as an adjunct therapy in patients who do not respond well to conventional treatment, which includes immunosuppression therapies, anti-anxiety medications, muscle relaxants, anticonvulsants, and pain relievers.

Methods: We retrospectively analyzed the clinical data and outcomes of ten patients with the clinical diagnosis of anti-GAD65 positive SPS in which TPE was employed to improve symptoms refractory to conventional treatment during an eight-year period. Read More

Aliment Pharmacol Ther 2019 Apr 4. Epub 2019 Apr 4.

Gastroenterology, Salford Royal NHS Foundation Trust, Salford, UK.

Background: Chronic continuous abdominal pain (CCAP) is characteristic of centrally mediated gastrointestinal pain disorders. It consumes significant healthcare resources yet is poorly understood, with minimal cohort-specific data in the literature.

Aims: To examine in a large cohort of CCAP patients, (a) diagnostic features, (b) iatrogenic impact of opioids and surgery, (c) drug treatment effects and tolerance. Read More

Proc (Bayl Univ Med Cent) 2018 Oct 26;31(4):532-533. Epub 2018 Sep 26.

Division of Pain Management, Department of Anesthesiology, Scott & White Medical CenterTempleTexas.

Dorsal root ganglion stimulation is a fairly recent treatment that has emerged in chronic pain management, often used in cases involving patients with complex regional pain syndrome. We describe a 24-year-old woman with severe left hip pain secondary to avascular necrosis in whom multiple treatments failed, including oral analgesics and radiofrequency ablation. A dorsal root ganglion stimulator was implanted with significant pain relief. Read More

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Surgery, College of Medicine, University of Duhok, Duhok, Kurdistan Region, Iraq.

A 35-year-old woman presented to the surgical clinic complaining of right hypochondrial pain for 4 days. Abdominal examination revealed tenderness on deep palpation in the right hypochonrdium, with no palpable organs or masses. The patient had repeated attacks of the same pain that mandated repeated admissions to the emergency hospital and treated conservatively. Read More

J Psychosom Res 2019 Apr 25;119:1-7. Epub 2019 Jan 25.

Division of Gastroenterology, Department of Clinical and Experimental Medicine, Linköping University, Sweden.

Objectives: Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disease associated with impaired quality of life and an increased use of healthcare services. Self-ratings of health have proven a powerful predictor of health outcomes. The aim of this study was to evaluate the unique impacts of comorbidities, gastrointestinal symptoms, perceived stress and sense of coherence on the number of healthcare contacts and self-rated health of IBS patients in Swedish primary care. Read More

Stereotact Funct Neurosurg 2019 Apr 4:1-6. Epub 2019 Apr 4.

Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA,

Background: Spinal cord stimulation (SCS) is a well-established therapy for chronic pain syndromes, with growing applicability to other conditions. Restless legs syndrome (RLS) is a widespread, chronic movement disorder managed primarily and incompletely by medication, and its etiology can be classified as idiopathic or secondary.

Methods: Three patients underwent SCS implantation for chronic back and/or leg pain with concomitant targeting of RLS: (1) a 34-year-old man with sporadic RLS symptoms that strongly intensified after military-related spinal fractures, (2) a 54-year-old man with RLS likely secondary to meralgia paresthetica, and (3) a 42-year-old man with low back and right lower extremity pain after a military motor vehicle accident. Read More

Aging Male 2019 Apr 4:1-8. Epub 2019 Apr 4.

a Department of Urology , Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung , Taiwan.

Purpose: Applying low-intensity extracorporeal shockwave therapy (LI-ESWT) has been reported to improve symptoms of refractory chronic pelvic pain syndrome (CPPS) in short-term follow-up. This study aims to demonstrate the effect of LI-ESWT on refractory CPPS over the span of a 12-month follow-up.

Materials And Methods: This was an open-label, single-arm prospective study. Read More

Neurourol Urodyn 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Aims: The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Read More

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019839647

1 Service d'Orthopédie-Traumatologie, Hôpital Gabriel Montpied, CHU de Clermont Ferrand BP 69, Clermont Ferrand, France.

A 20-year-old patient came to the sport medicine clinic for bilateral forefoot pain during sport activities (running) progressing for the last 3 months. Thanks to a positive measurement of the compartment pressure during a running test reproducing the symptomatology and exclusion of classical differential diagnosis, a bilateral chronic compartment syndrome of the lateral forefoot was confirmed. Three months after a surgical fasciotomy, the patient fully recovered. Read More

Phlebology 2019 Apr 3:268355519840846. Epub 2019 Apr 3.

1 Center for Vein Restoration, Greenbelt, MD, USA.

Introduction: Women with pelvic venous insufficiency often present with lower extremity symptoms and manifestations of chronic venous disorders. The purpose of this investigation was to determine the incidence of lower extremity chronic venous disorders and the types and distribution of lower extremity veins involved in patients with a known diagnosis of pelvic venous insufficiency.

Methods: Between January 2012 and December 2015, we retrospectively reviewed the charts of 227 women with pelvic venous insufficiency as well as their lower extremity venous duplex investigations. Read More

Am J Physiol Renal Physiol 2019 Apr 3. Epub 2019 Apr 3.

Urology, Qilu Hospital of Shandong University, China.

The etiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still unknown. Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to play an important role in the development of autoimmune and inflammatory diseases. Here, we investigated the expression and function of GM-CSF in CP/CPPS patients and in a mouse model of Experimental Autoimmune prostatitis (EAP). Read More

Nurs Res 2019 Apr 1. Epub 2019 Apr 1.

Associate Professor, Instituto de Investigación Biosanitaria Granada (IBIS, Granada), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain PhD Candidate, Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Spain PhD Candidate, Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Spain Associate Professor, Department of Health Sciences, University of Jaén, Paraje Las Lagunillas, Jaén, Spain Associate Professor, Department of Cell Biology, University of Granada, Granada, Spain Professor, Instituto de Investigación Biosanitaria Granada (IBIS, Granada), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain Instituto de Investigación Biosanitaria Granada, Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Spain.

Background: There is very little scientific literature on the potential relationships between modifiable factors, including body composition, dietary pattern and physical activity (PA), and bone status in patients with fibromyalgia: A musculoskeletal condition characterized by chronic, widespread pain that is often accompanied by a broad spectrum of symptoms.

Objectives: To investigate the impact of body composition parameters, adherence to the Mediterranean diet (Med Diet), and PA on bone health in a population of premenopausal and postmenopausal women with fibromyalgia syndrome (FMS).

Methods: Ninety-five women diagnosed with FMS were included in this cross-sectional study. Read More

Cochrane Database Syst Rev 2019 Apr 2;4:CD011118. Epub 2019 Apr 2.

Cochrane Pain, Palliative and Supportive Care Group, Pain Research Unit, Churchill Hospital, Oxford, UK.

Background: This is the first update of a review published in 2015, Issue 1. Chronic pain is common during childhood and adolescence and is associated with negative outcomes, such as increased severity of pain, reduced function, and low mood. Psychological therapies, traditionally delivered face-to-face with a therapist, are efficacious at reducing pain intensity and disability. Read More

PLoS One 2019 2;14(4):e0213834. Epub 2019 Apr 2.

Department of Gynecology and Gynecological Oncology, University Women`s Hospital of Basel, University of Basel, Basel, Switzerland.

Objectives: Pelvic congestion syndrome is defined as chronic pelvic pain due to incompetent (dilated and refluxing) pelvic veins. The aim of this study was to investigate the prevalence of this condition by examining the prevalence of dilated ovarian and para-uterine veins in pre- and postmenopausal female patients, irrespective of their symptoms. We subsequently investigated how many women with dilated veins suffered from chronic pelvic pain. Read More

Khirurgiia (Mosk) 2019 (3):121-128

Chair of Surgical Diseases of Pediatric and Dental Faculties, Volgograd State Medical University of Ministry of Health of the Russian Federation, Volgograd, Russia.

This article is devoted to general and particular problems of inguinal hernia repair through the analysis of statistical data and comparison of advantages and disadvantages of various methods of inguinal hernia repair. Particular attention is paid to the analysis of current options of mesh implant fixing during endoscopic hernia repair: TAPP, TER, e-TER. Long-term outcomes are essential to determine surgical technique. Read More

A A Pract 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.

Restless legs syndrome can be a debilitating condition that affects a patient's ability to function and their quality of life. Neuromodulation may represent a potential option for nonpharmacological management of restless legs syndrome. We present 3 patients who have a chronic pain diagnosis and medically refractory restless legs syndrome that warranted neuromodulation. Read More

Arch Ital Urol Androl 2019 Mar 29;91(1):16-21. Epub 2019 Mar 29.

Acibadem Mehmet Ali Aydinlar University, Urology, Istanbul.

Objective: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common problem and severely impairs the quality of life (QoL). We aimed to investigate the effects of different treatment options on voiding symptoms and QoL in patients with urinary phenotype according to the UPOINT system. Matherial and methods: Ninety-six patients with NIH category II,III CP/CPPS were included in the study prospectively. Read More

Yakugaku Zasshi 2019 ;139(4):641-645

Department of Pharmacy, Okayama University Hospital.

We herein present the case of a 66-year-old Japanese man with Fanconi's syndrome. He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles. Renal dysfunction, hypophosphatemia, and increased levels of bone alkaline phosphatase were found by a hematology test after admission for treatment of HCC. Read More

J Psychosom Res 2019 May 21;120:1-7. Epub 2019 Feb 21.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Aims: To investigate the combined impact of somatic and psychosocial factors on symptom severity and physical and mental quality of life (QoL) in male and female patients with chronic pelvic pain syndrome (CPPS).

Methods: We examined 234 patients aged 18 to 84 years attending an interdisciplinary outpatient clinic for patients with CPPS in Hamburg, Germany. Using self-reports, we assessed CPPS symptom severity (NIH-CPSI), with the female counterpart of each male anatomical site used in the questionnaire for women; physical and mental QoL (SF-12) as well as symptoms of depression (PHQ-9) and anxiety (GAD-7); pain catastrophizing cognitions (PCS); social support (F-SozU) and medication intake. Read More

J Neuroinflammation 2019 Mar 30;16(1):67. Epub 2019 Mar 30.

Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underlying the association between pain and chronic stress using this rat model. Read More

Epilepsy Res 2019 Mar 22;153:19-27. Epub 2019 Mar 22.

Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia. Electronic address:

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a result of interplay between psychological, immune, neurological and genetic factors, manifested by variety of urological, as well as brain-related symptoms. However, its relation with brain excitability has not been addressed. herefore, our aim was to assess susceptibility to seizures in rats with CP/CPPS. Read More

Clin Rheumatol 2019 Mar 29. Epub 2019 Mar 29.

Albert Einstein College of Medicine, Bronx, NY, USA.

To investigate specific disease patterns in the rheumatic manifestations associated with autoimmune thyroid disease (AITD) through a systematic literature review. We performed a systematic review using the Medline OVID, PubMed, EMBASE, and Web of Science databases through May 2018 for experimental and observational studies that explored the association of AITD with degenerative joint disease (DJD), osteoarthritis (OA), chronic widespread pain (CWP) and fibromyalgia syndrome (FMS), and seronegative inflammatory arthritis (IA). A total of 2132 articles were identified. Read More

Dtsch Med Wochenschr 2019 Apr 29;144(7):478-483. Epub 2019 Mar 29.

Klinik für Angiologie, Klinikum Hochsauerland GmbH, Arnsberg.

Approximately 60 % of patients with acute iliofemoral deep vein thrombosis recover without further symptoms. However, 40 % will have some degree of post-thrombotic syndrome (PTS) and 4 % will develop severe PTS. PTS is the most common complication; it reduces quality of life and increases DVT-related costs. Read More

Pain 2019 Mar 27. Epub 2019 Mar 27.

Departments of Oral and Maxillofacial Surgery and.

Chronic muscle pain is a prominent symptom of the hand-arm vibration syndrome (HAVS), an occupational disease induced by exposure to vibrating power tools, but the underlying mechanism remains unknown. We evaluated the hypothesis that vibration induces an interleukin 6 (IL-6)-mediated downregulation of the potassium voltage-gated channel subfamily A member 4 (KV1.4) in nociceptors leading to muscle pain. Read More

Pol Przegl Chir 2018 Dec;91(1):1-5

Ukrainian Hernia Society P.L. Shupyk National Medical Academy of Postgraduate Education, Department of Surgery and Proctology; Ukrainian Center for Surgical Treatment of Abdominal Hernia.

The use of the anterior technique for abdominal wall components separation combined with "onlay" alloplasty (ACST + onlay) in giant incisional hernias (IH) may pose a surgical challenge as it does not exclude increased intra-abdominal pressure (IAP) and the occurrence of abdominal compartment syndrome (ACS). There remains a high incidence of surgical site complications. In our view, the use of intra-abdominal alloplasty combined with anterior separation of the anterior abdominal wall components (ACST + IPOM) will contribute to the improvement of surgical outcomes in giant IH. Read More

Metabolomics 2019 Mar 27;15(4):54. Epub 2019 Mar 27.

Faculty of Natural and Agricultural Sciences, Centre for Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom, South Africa.

Introduction: Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Previous analyses of untargeted metabolomics data indicated altered metabolic profile in FMS patients.

Objectives: We report a semi-targeted explorative metabolomics study on the urinary metabolite profile of FMS patients; exploring the potential of urinary metabolite information to augment existing medical diagnosis. Read More

Oper Orthop Traumatol 2019 Mar 27. Epub 2019 Mar 27.

Sektion für Fuß- und Sprunggelenkchirurgie, Klinik für Allgemeine, Unfall- und Wiederherstellungschirurgie, LMU München, Ludwig-Maximilians-Universität, Nußbaumstraße 20, 80336, München, Deutschland.

Objective: Repair of the lateral ligament complex of the ankle joint; identification and treatment of intra-articular pathologies.

Indications: Symptomatic chronic lateral ankle instability. Treatment of osteochondral lesions associated with lateral ankle instability. Read More

Am J Hosp Palliat Care 2019 Mar 27:1049909119838974. Epub 2019 Mar 27.

2 Hospice and Palliative Medicine, Ballad Health System, Kingsport, TN, USA.

Pain can have a devastating effect on the quality of life of patients in palliative medicine. Thus far, majority of research has been centered on opioid-based pain management, with a limited empirical evidence for the use of nonopioid medications in palliative care. However, opioid and nonopioid medications such as nonsteroidal anti-inflammatory drugs have their limitations in the clinical use due to risk of adverse effects, therefore, there is a need for more research to be directed to finding an alternative approach to pain management in comfort care setting. Read More