73,580 results match your criteria Chronic Obstructive Pulmonary Disease


Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke.

Exp Gerontol 2019 Jan 16. Epub 2019 Jan 16.

Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy. Electronic address:

Inflammation and cellular senescence (also called inflammaging) are involved in the pathogenesis of premature lung aging, a key driver of chronic obstructive pulmonary disease (COPD). Downregulation of histone deacetylases and FoxO3 expression, activation of the ERK 1/2 pathway and IL-8 increase are hallmarks of lung inflammaging. The effects of Budesonide (BUD), Aclidinium (ACL) and Formoterol (FO) on lung inflammaging are unknown. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.016DOI Listing
January 2019

Prognostic factors for one-year mortality in patients with acute heart failure with and without chronic kidney disease: differential impact of beta-blocker and diuretic treatments.

Hypertens Res 2019 Jan 18. Epub 2019 Jan 18.

Division of Cardiology, Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

The pathophysiology and treatment of acute decompensated heart failure (HF) in the presence of chronic kidney disease (CKD) remain ill defined. Here we compared the prognostic factors for 1-year mortality in patients with acute HF with and without CKD. We retrospectively studied 392 consecutive patients with acute decompensated HF. Read More

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http://dx.doi.org/10.1038/s41440-018-0204-4DOI Listing
January 2019

"Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI".

Acad Radiol 2019 Jan 15. Epub 2019 Jan 15.

Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Rm. 2488, 1111 Highland Ave., Madison, WI; Department of Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI; Department of Medicine, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI; Department of Biomedical Engineering, College of Engineering, University of Wisconsin - Madison, Madison, WI. Electronic address:

Rationale And Objectives: The purpose of this review is to acquaint the reader with recent advances in ultrashort echo time (UTE) magnetic resonance imaging (MRI) of the lung and its implications for pulmonary MRI when used in conjunction with functional MRI technique.

Materials And Methods: We provide an overview of recent technical advances of UTE and explore the advantages of combined structure-function pulmonary imaging in the context of restrictive and obstructive pulmonary diseases such as idiopathic pulmonary fibrosis (IPF) and cystic fibrosis (CF).

Results: UTE MRI clearly shows the lung parenchymal changes due to IPF and CF. Read More

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http://dx.doi.org/10.1016/j.acra.2018.12.007DOI Listing
January 2019

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases.

Respir Res 2019 Jan 18;20(1):14. Epub 2019 Jan 18.

MedImmune LLC, One MedImmune Way, #4552B, Gaithersburg, MD, USA.

Background: Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated efficacy for patients with moderate to severe asthma and, in a Phase IIa trial, for chronic obstructive pulmonary disease (COPD) with eosinophilic inflammation. We investigated effects of benralizumab 100 mg every 8 weeks (first three doses every 4 weeks) subcutaneous on blood inflammatory markers through proteomic and gene-expression analyses collected during two Phase II studies of patients with eosinophilic asthma and eosinophilic COPD. Read More

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http://dx.doi.org/10.1186/s12931-018-0968-8DOI Listing
January 2019

The role of MMP-12 gene polymorphism - 82 A-to-G (rs2276109) in immunopathology of COPD in polish patients: a case control study.

BMC Med Genet 2019 Jan 18;20(1):19. Epub 2019 Jan 18.

Second Department of Internal Medicine of Collegium Medicum, Jagiellonian University in Cracow, Skawińska street 8, 31-066, Kraków, Poland.

Background: Major symptoms of chronic obstructive pulmonary disease (COPD) are chronic bronchitis and emphysema leading from lung tissue destruction, that is an effect of an imbalance between metalloproteinases (MMPs) and their tissue inhibitors activity. As potential factor involved in this COPD pathogenesis, MMP-12 is considered. We investigated the role of genetic polymorphism and protein level of MMP-12 in the COPD development among Poles. Read More

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http://dx.doi.org/10.1186/s12881-019-0751-9DOI Listing
January 2019

Evaluating Hospital Readmissions for Persons With Serious and Complex Illness: A Competing Risks Approach.

Med Care Res Rev 2019 Jan 18:1077558718823919. Epub 2019 Jan 18.

4 VCU Medical Center, Richmond, VA, USA.

Hospital readmission rate is a ubiquitous measure of efficiency and quality. Individuals with life-limiting illnesses account heavily for admissions but evaluation is complicated by high-mortality rates. We report a retrospective cohort study examining the association between palliative care (PC) and readmissions while controlling for postdischarge mortality with a competing risks approach. Read More

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http://dx.doi.org/10.1177/1077558718823919DOI Listing
January 2019

The impact of key modifiable risk factors on leading chronic conditions.

Prev Med 2019 Jan 15. Epub 2019 Jan 15.

Yale University Prevention Research Center, Yale University School of Medicine, New Haven, CT, USA; Sickness Prevention Achieved through Regional Collaboration (SPARC, Inc.), Newton, MA, USA. Electronic address:

We studied associations between 7 cardiovascular disease (CVD) risk factors (RFs) and 9 chronic conditions and estimated population-attributable risk. Data (N = 358,218) were from the 2017 Behavioral Risk Factor Surveillance System. Outcomes included asthma, arthritis, chronic obstructive pulmonary disease (COPD), cognitive impairment, CVD, and kidney disease. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.01.006DOI Listing
January 2019

Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis.

J Cachexia Sarcopenia Muscle 2019 Jan 18. Epub 2019 Jan 18.

Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Background: Pulmonary rehabilitation (PR) is a cornerstone in the management of chronic obstructive pulmonary disease (COPD), targeting skeletal muscle to improve functional performance. However, there is substantial inter-individual variability in the effect of PR on functional performance, which cannot be fully accounted for by generic phenotypic factors. We performed an unbiased integrative analysis of the skeletal muscle molecular responses to PR in COPD patients and comprehensively characterized their baseline pulmonary and physical function, body composition, blood profile, comorbidities, and medication use. Read More

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http://dx.doi.org/10.1002/jcsm.12370DOI Listing
January 2019

Ensifentrine (RPL554): an inhaled 'bifunctional' dual PDE3/4 inhibitor for the treatment of asthma and chronic obstructive pulmonary disease.

Pharm Pat Anal 2019 Jan 18. Epub 2019 Jan 18.

Unit of Pharmacology, Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.

Ensifentrine (RPL554), an inhaled 'bifunctional' dual phosphodiesterase 3/4 inhibitor that exhibits both bronchodilator and anti-inflammatory activities, provides a new option in the treatment of chronic obstructive pulmonary disease (COPD) and other inflammatory airway diseases that are under clinical development. Ensifentrine appears to be initially under development for the treatment of COPD although it is not yet clear whether it should be understood as an add-on therapy in patients for the treatment of acute exacerbations of COPD or for the regular maintenance treatment of patients either alone, or on top of existing drug classes. Read More

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http://dx.doi.org/10.4155/ppa-2018-0030DOI Listing
January 2019
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Longitudinal analysis to better characterize Asthma-COPD Overlap Syndrome (ACOS): Findings from an adult asthma cohort in Korea (COREA).

Clin Exp Allergy 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, Asan Medical Center, Ulsan University School of Medicine, Seoul, Korea.

Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), which has received much attention, has not been unanimously defined.

Objective: In this study, we tried to demonstrate that longitudinally defined ACOS is more useful in the real-world than blending patients with asthma and COPD.

Methods: The study patients had undergone two consecutive pulmonary function tests measured at least 3 months apart (n = 1,889). Read More

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http://dx.doi.org/10.1111/cea.13339DOI Listing
January 2019

Lund-Mackay Computed Tomography Score Is Associated With Obstructive Pulmonary Function Changes in Chronic Cough Patients.

Am J Rhinol Allergy 2019 Jan 18:1945892418825094. Epub 2019 Jan 18.

1 Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: A remarkable relationship between upper airway conditions and lung diseases has been reported. At the same time, sinonasal findings in chronic cough patients have not been fully examined.

Objective: The purpose of this study is to show paranasal sinus findings and lung function in chronic cough patients without asthma and chest X-ray abnormalities. Read More

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http://dx.doi.org/10.1177/1945892418825094DOI Listing
January 2019

Chronic obstructive pulmonary disease assessment test: usefulness for monitoring recovery and predicting poor course of disease after exacerbations.

Emergencias 2019 Ene;31(1):21-26

Unidad de Investigación, OSI Barrualde-Galdakao, Galdakao, Bizkaia2 Red de Investigación en Servicios de Salud en Enfermedades Crónicas [REDISSEC], Galdakao, Bizkaia, España.

Objectives: To assess the usefulness of the chronic obstructive pulmonary disease (COPD) assessment test (CAT) for evaluating recovery from an acute exacerbation of chronic COPD. To assess whether the CAT score used along with a COPD exacerbation severity scale can better predict risk of a poor course of disease.

Material And Methods: Prospective multicenter cohort study enrolling patients who attended hospital emergency departments with symptoms of exacerbated COPD. Read More

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January 2019

Influencing factors of pneumothorax and parenchymal haemorrhage after CT-guided transthoracic needle biopsy: single-institution experience.

Pol J Radiol 2018 26;83:e379-e388. Epub 2018 Jul 26.

Department of Radiology, Faculty of Medicine, Thammasat University Hospital, Pathum Thani, Thailand.

Purpose: To evaluate the incidences and influencing factors of pneumothorax and parenchymal haemorrhage after computed tomography (CT)-guided transthoracic needle biopsy (TTNB).

Material And Methods: A retrospective analysis of 216 patients who underwent CT-guided TTNB was performed. The frequencies and risk factors of pneumothorax and parenchymal haemorrhage were determined. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.79202
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http://dx.doi.org/10.5114/pjr.2018.79202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334090PMC
July 2018
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The association between recent hospitalized COPD exacerbations and adverse outcomes after percutaneous coronary intervention: a nationwide cohort study.

Int J Chron Obstruct Pulmon Dis 2019 3;14:169-179. Epub 2019 Jan 3.

Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan,

Purpose: COPD is associated with coronary artery disease, and exacerbations are major events in COPD. However, the impact of recent hospitalized exacerbations on outcomes of percutaneous coronary intervention (PCI) remains underdetermined.

Patients And Methods: Using the National Health Insurance Research Database of Taiwan, we identified 215,275 adult patients who underwent first-time PCI between 2000 and 2012. Read More

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https://www.dovepress.com/the-association-between-recent-hos
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http://dx.doi.org/10.2147/COPD.S187345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322514PMC
January 2019
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Altered serum levels of type I collagen turnover indicators accompanied by IL-6 and IL-8 release in stable COPD.

Int J Chron Obstruct Pulmon Dis 2019 3;14:163-168. Epub 2019 Jan 3.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China,

Background: COPD, characterized by chronic inflammation and airway remodeling, has significant pathological alterations in composition and deposition of the extracellular matrix. The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies.

Purpose: In this study, we investigated whether the serum concentrations of PICP and ICTP were associated with the inflammation level for patients with stable COPD. Read More

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http://dx.doi.org/10.2147/COPD.S188139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322508PMC
January 2019

Relationships of Haptoglobin Phenotypes with Systemic Inflammation and the Severity of Chronic Obstructive Pulmonary Disease.

Sci Rep 2019 Jan 17;9(1):189. Epub 2019 Jan 17.

Division of Thoracic Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. Read More

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http://dx.doi.org/10.1038/s41598-018-37406-9DOI Listing
January 2019

Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness tiotropium alone in COPD.

Eur Respir J 2019 Jan 17. Epub 2019 Jan 17.

Queen's University and Kingston General Hospital, Kingston, Canada.

The 3-minute constant speed shuttle test (3-min CSST) was used to examine the effect of tiotropium/olodaterol compared with tiotropium at reducing activity-related breathlessness in patients with chronic obstructive pulmonary disease (COPD). This was a randomised, double-blind, two-period crossover study including COPD patients with moderate to severe pulmonary impairment, lung hyperinflation at rest and a Mahler Baseline Dyspnoea Index <8. Patients received 6 weeks of tiotropium/olodaterol 5/5 µg and tiotropium 5 µg in a randomised order with a 3-week washout period. Read More

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http://dx.doi.org/10.1183/13993003.02049-2018DOI Listing
January 2019

Reductions in 30-day readmission, mortality, and costs with inpatient-to-community pharmacist follow-up.

J Am Pharm Assoc (2003) 2019 Jan 14. Epub 2019 Jan 14.

Objectives: To determine the impact of pharmacist-provided continuous care and electronic communication on readmissions among a group of high-risk patients.

Design: Pragmatic interventional study with 5:1 matched control.

Setting And Participants: Patients discharged from any of 4 hospitals with chronic obstructive pulmonary disease, pneumonia, heart failure, acute myocardial infarction, or diabetes within Pennsylvania. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15443191183047
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http://dx.doi.org/10.1016/j.japh.2018.11.005DOI Listing
January 2019
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Increased pain sensitivity, postural abnormalities, and functional balance impairment in obstructive lung disease compared to healthy subjects.

Heart Lung 2019 Jan 14. Epub 2019 Jan 14.

Hacettepe University, Faculty of Medicine, Department of Chest Diseases, Ankara, Turkey.

Background: Recent reports have identified pain as a comorbidity in obstructive lung diseases, but data regarding pain in certain obstructive lung diseases such as COPD and bronchiectasis vs. healthy controls and differences in pain between these chronic lung diseases are limited.

Objectives: The primary aim of this study was to compare pain sensitivity, postural abnormalities, and functional balance in patients with COPD/bronchiectasis vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01479563183031
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http://dx.doi.org/10.1016/j.hrtlng.2018.12.009DOI Listing
January 2019
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Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway.

Biochem Biophys Res Commun 2019 Jan 14. Epub 2019 Jan 14.

The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Previous work has confirmed that the chronic hypoxia-hypercapnia (CHH) associated with chronic obstructive pulmonary disease contributes to the development of skeletal muscle atrophy. Neuromuscular Electrical Stimulation (NMES) has shown some efficacy when used as a treatment to reduce skeletal muscle atrophy. The present study focuses on the MicroRNA-486/PTEN/FoxO1 pathway with the goal of identifying its physiological role in skeletal muscle atrophy induced by CHH as well as its role during NMES treatment. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.12.147DOI Listing
January 2019

Development of a Portable Dielectric Biosensor for Rapid Detection of Viscosity Variations and Its In Vitro Evaluations Using Saliva Samples of COPD Patients and Healthy Control.

Healthcare (Basel) 2019 Jan 16;7(1). Epub 2019 Jan 16.

IHP-Leibniz-Institut für innovative Mikroelektronik, Im Technologiepark 25, 15236 Frankfurt/Oder, Germany.

Chronic Obstructive Pulmonary Disease (COPD) is a life-threatening lung disease affecting millions of people worldwide. Although the majority of patients with objective COPD go undiagnosed until the late stages of their disease, recent studies suggest that the regular screening of sputum viscosity could provide important information on the disease detection. Since the viscosity of sputum is mainly defined by its mucin⁻protein and water contents, dielectric biosensors can be used for detection of viscosity variations by screening changes in sputum's contents. Read More

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http://dx.doi.org/10.3390/healthcare7010011DOI Listing
January 2019

Safety and Tolerability of Comprehensive Research Bronchoscopy in COPD: Results from the SPIROMICS Bronchoscopy Sub-Study.

Ann Am Thorac Soc 2019 Jan 17. Epub 2019 Jan 17.

University of Michigan, Pulmonary & Critical Care, Ann Arbor, Michigan, United States.

Rationale: There is an unmet need to investigate the lower airways in chronic obstructive pulmonary disease (COPD) to define pathogenesis and to identify potential markers to accelerate therapeutic development. Although bronchoscopy is well-established to sample airways in various conditions, a comprehensive COPD research protocol is not currently published.

Objectives: To evaluate the safety and tolerability of a comprehensive research bronchoscopy procedure suitable for multicenter trials and to identify factors associated with adverse events. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201807-441OCDOI Listing
January 2019
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Carbon monoxide poisoning in Denmark with focus on mortality and factors contributing to mortality.

PLoS One 2019 17;14(1):e0210767. Epub 2019 Jan 17.

Department of Cardiothoracic Surgery, Aalborg University Hospital, Aalborg, Denmark.

Introduction: Carbon monoxide (CO) poisoning is frequent worldwide but knowledge regarding the epidemiology is insufficient. The aim of this study was to clarify the extent of this intoxication, its mortality and factors associated with mortality.

Materials And Methods: National databases from Statistics Denmark were used to identify individuals who suffered from CO-poisoning during 1995-2015, as well as information regarding co-morbidities, mortality and manner of death. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210767PLOS
January 2019
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Which Method to Use for Surgical Ablation of Atrial Fibrillation Performed Concomitantly with Mitral Valve Surgery: Radiofrequency Ablation versus Cryoablation.

Braz J Cardiovasc Surg 2018 Nov-Dec;33(6):542-552

Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Objective: The effects of energy source on the maintenance of sinus rhythm and the contribution of demographic characteristics to the case selection in patients submitted to ablation performed concurrently with mitral valve surgery were analyzed.

Methods: Cryothermal (n=42; 43.8%) and radiofrequency (n=54; 56. Read More

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http://www.bjcvs.org/pdfRBCCV/v33n6a05.pdf
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http://dx.doi.org/10.21470/1678-9741-2018-0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326442PMC
May 2018
1 Read

Decreased miR-29b expression is associated with airway inflammation in chronic obstructive pulmonary disease.

Am J Physiol Lung Cell Mol Physiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.

Chronic obstructive pulmonary disease (COPD) is a common chronic airway inflammatory disease. MicroRNAs are shown to be involved in the regulation of inflammation. We investigated the role of microRNA-29b (miR-29b) in the airway inflammation in COPD. Read More

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https://www.physiology.org/doi/10.1152/ajplung.00436.2018
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http://dx.doi.org/10.1152/ajplung.00436.2018DOI Listing
January 2019
1 Read

Contribution of chronic diseases to educational disparity in disability in France: results from the cross-sectional "disability-health" survey.

Arch Public Health 2019 11;77. Epub 2019 Jan 11.

1Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Background: This study aimed 1) to assess whether the contribution of chronic conditions to disability varies according to the educational attainment, 2) to disentangle the contributions of the prevalence and of the disabling impact of chronic conditions to educational disparities.

Methods: Data of the 2008-09 Disability Health Survey were examined ( = 23,348). The disability indicator was the Global Activity Limitation Indicator (GALI). Read More

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http://dx.doi.org/10.1186/s13690-018-0326-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330417PMC
January 2019
1 Read

GOLD stage predicts thoracic aortic calcifications in patients with COPD.

Exp Ther Med 2019 Jan 30;17(1):967-973. Epub 2018 Nov 30.

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, D-69120 Heidelberg, Germany.

Although some of the associations between chronic obstructive pulmonary disease (COPD) and atherosclerosis are based on shared risk factors such as smoking, recent epidemiological evidence suggests that COPD is a risk factor for vascular disease due to systemic inflammation. The present study assessed the hypothesis that disease severity (as expressed by the GOLD stage) independently predicts the extent of vascular calcifications. A total of 160 smokers diagnosed with COPD (GOLD I-IV, 40 subjects of each GOLD stage) and 40 smokers at risk (GOLD 0; median age of 60 years old; Q1:56;Q3:65; 135 males and 65 females) underwent non-contrast, non-electrocardiography synchronized chest computerised tomography. Read More

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http://dx.doi.org/10.3892/etm.2018.7039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307445PMC
January 2019
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Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells.

Exp Ther Med 2019 Jan 8;17(1):519-524. Epub 2018 Nov 8.

Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China.

The diaphragmatic fatigue that results from airflow obstruction is associated with the severe morbidity of patients with chronic obstructive pulmonary disease. Astragaloside IV (AS-IV) has antioxidant, anti-apoptotic and anti-inflammatory activities in various cell types. The present study aimed to evaluate the protective effects of AS-IV in diaphragmatic muscle cells. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.6940
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http://dx.doi.org/10.3892/etm.2018.6940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307367PMC
January 2019
2 Reads

Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study.

BMC Cardiovasc Disord 2019 Jan 16;19(1):20. Epub 2019 Jan 16.

Cardio-Thoracic-Vascular Department, Policlinico S. Orsola-Malpighi, Università di Bologna, Via Albertoni 15, 40138, Bologna, Italy.

Background: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical condition. Indacaterol/glycopirronium has shown benefits in the treatment of COPD, with few cardiologic adverse effects. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-018-0986-yDOI Listing
January 2019
2 Reads

Intermittent Use of Portable NIV Increases Exercise Tolerance in COPD: A Randomised, Cross-Over Trial.

J Clin Med 2019 Jan 15;8(1). Epub 2019 Jan 15.

Northumbria Healthcare NHS Foundation Trust, Respiratory Medicine, North Tyneside & Northumberland NE29 8NH, UK.

During exercise, non-invasive ventilation (NIV) prolongs endurance in chronic obstructive pulmonary disease (COPD), but routine use is impractical. The VitaBreath device provides portable NIV (pNIV); however, it can only be used during recovery. We assessed the effect of pNIV compared to pursed lip breathing (PLB) on exercise tolerance. Read More

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http://dx.doi.org/10.3390/jcm8010094DOI Listing
January 2019

Molecular Pathways and Respiratory Involvement in Lysosomal Storage Diseases.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Rare Metabolic Diseases Unit, Pediatric Department, Fondazione MBBM, Università degli Studi di Milano Bicocca, San Gerardo Hospital, ASST di Monza, 20900 Monza, Italy.

Lysosomal storage diseases (LSD) include a wide range of different disorders with variable degrees of respiratory system involvement. The purpose of this narrative review is to treat the different types of respiratory manifestations in LSD, with particular attention being paid to the main molecular pathways known so far to be involved in the pathogenesis of the disease. A literature search was conducted using the Medline/PubMed and EMBASE databases to identify studies, from 1968 through to November 2018, that investigated the respiratory manifestations and molecular pathways affected in LSD. Read More

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http://dx.doi.org/10.3390/ijms20020327DOI Listing
January 2019

Can Early Introduction of Palliative Care Limit Intensive Care, Emergency and Hospital Admissions in Patients with Severe Chronic Obstructive Pulmonary Disease? A Pilot Randomized Study.

Respiration 2019 Jan 16:1-10. Epub 2019 Jan 16.

Department of Community Medicine, Primary Care, and Emergency, Geneva University Hospitals, Geneva, Switzerland.

Background: Despite their poor prognosis, patients with severe chronic obstructive pulmonary disease (COPD) have little access to palliative care and tend to have a high rate of hospital and intensive care unit (ICU) admissions during their last year of life.

Objectives: To determine the feasibility of a home palliative care intervention during 1 year versus usual care, and the possible impact of this intervention on emergency, hospital and ICU admissions, survival, mood, and health-related quality of life (HRQL).

Methods: Prospective controlled study of patients with severe COPD (GOLD stage III or IV) and long-term oxygen therapy and/or home noninvasive ventilation and/or one or more hospital admissions in the previous year for acute exacerbation, randomized to usual care versus usual care with add-on monthly intervention by palliative care specialists at home for 12 months. Read More

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http://dx.doi.org/10.1159/000495312DOI Listing
January 2019

Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.

Acta Cardiol 2019 Jan 16:1-8. Epub 2019 Jan 16.

a University of Medicine and Pharmacy of Tîrgu Mureș , Tîrgu Mureș , Romania.

Background: Atrial fibrillation (AF) often complicates ST-segment elevation myocardial infarction (STEMI). Predictors of AF in this setting include factors related to the acute phase of STEMI and pre-existing conditions. More recently, novel AF predictors have been identified in the general population. Read More

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http://dx.doi.org/10.1080/00015385.2018.1521558DOI Listing
January 2019

Heart failure and chronic obstructive pulmonary disease: a review.

Acta Cardiol 2019 Jan 16:1-8. Epub 2019 Jan 16.

a Internal Medicine Clinic , Clinical Emergency Hospital of Bucharest , Bucharest , Romania.

Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are important causes of morbidity and mortality worldwide. The association between the two conditions have significant systemic effects and a chronic, progressive evolution, affecting exercise tolerance and quality of life. The diseases share common risk factors, such as smoking, advanced age, and low-grade systemic inflammation. Read More

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https://www.tandfonline.com/doi/full/10.1080/00015385.2018.1
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http://dx.doi.org/10.1080/00015385.2018.1559485DOI Listing
January 2019
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Burden and causes for hospitalizations following coronary artery bypass grafting: a nationwide cohort study.

Eur J Cardiothorac Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Hospitalizations are a major burden for both patients and society and are potentially preventable. However, data on the burden and causes for hospitalizations after coronary artery bypass grafting (CABG) are sparse. We examined hospitalizations within 1 year after CABG and associated factors. Read More

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezy418DOI Listing
January 2019
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The Diagnostic Tests for Detection of Helicobacter pylori Infection.

Monoclon Antib Immunodiagn Immunother 2019 Jan 16. Epub 2019 Jan 16.

1 Department of Microbiology, Shahr-e-Qods-Branch, Islamic Azad University, Tehran, Iran.

Helicobacter pylori causes one of the most common infections in human populations. The role of this bacterium in chronic gastritis, gastric ulcer, gastric cancer, as well as extra-digestive diseases such as ischemic heart disease and chronic obstructive pulmonary diseases, is well known. Prevention and control of these diseases can occur by early diagnosis and eradication of H. Read More

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https://www.liebertpub.com/doi/10.1089/mab.2018.0032
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http://dx.doi.org/10.1089/mab.2018.0032DOI Listing
January 2019
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Differences in clinical characteristics and one-year outcomes of hospitalized heart failure patients in succeeding European Society of Cardiology-Heart Failure Registries - Pilot and Long-Term.

Pol Arch Intern Med 2019 Jan 16. Epub 2019 Jan 16.

INTRODUCTION The management of heart failure (HF) has significantly changed in recent decades. OBJECTIVES The paper analyzes clinical profile, one-year outcomes, predictors of mortality and hospital readmissions in hospitalized patients enrolled in the European Society of Cardiology HF-Pilot (ESC-HF-Pilot) and HF-Long Term (ESC-HF-LT) Registries. PATIENTS AND METHODS The analysis included hospitalized Polish patients from the ESC-HF-Pilot and ESC-HF-LT Registries. Read More

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http://pamw.pl/en/node/4418
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http://dx.doi.org/10.20452/pamw.4418DOI Listing
January 2019
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Pulmonary Cavitary Disease Secondary to Mycobacterium xenopi Complicated by Respiratory Failure.

Cureus 2018 Oct 29;10(10):e3512. Epub 2018 Oct 29.

Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, USA.

Non-tuberculous mycobacteria (NTM) are a significant cause of pulmonary infection worldwide and can be clinically challenging. Mycobacterium xenopi (M. xenopi) has low pathogenicity and usually requires either host immune impairment, as in the case of a human immunodeficiency virus infection, or a structural lung disease to cause a clinical disease. Read More

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https://www.cureus.com/articles/14545-pulmonary-cavitary-dis
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http://dx.doi.org/10.7759/cureus.3512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318116PMC
October 2018
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Coronary endarterectomy: an old tool for patients currently operated on with coronary artery bypass grafting. Long-term results, risk factor analysis.

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):219-226. Epub 2018 Dec 31.

Department of Cardiac Surgery, Tor Vergata University Policlinic, Rome, Italy.

Aim: Coronary endarterectomy (CE) may provide a useful adjunctive technique to coronary artery bypass grafting (CABG) in patients with diffuse coronary artery disease. Nevertheless, the incidence of complications still remains high, long-term results remain unclear, and no risk factors for late mortality have been completely described yet.

Material And Methods: We retrospectively reviewed 90 consecutive patients (67 ±8. Read More

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http://dx.doi.org/10.5114/kitp.2018.80917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329878PMC
December 2018

Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats.

Chin Med Sci J 2018 Nov;33(4):260-266

Department of Geriatrics,Hangzhou First People's Hospital, Hangzhou 310006, China.

Objective To investigate the combined effects of chronic obstructive pulmonary disease (COPD) and depression on spatial memory in old rats, aiming to better understand the comorbidity of the two diseases in geriatric patients. Methods The SD rats were assigned into five groups: adult control group (n=6), elderly control group (n=6), elderly COPD group (n=6), elderly depression group (n=6) and elderly COPD with depression group (n=6). Smoking and chronic unpredictable mild stress (CUMS) with solitary support were used to induce COPD model, depression model, respectively, and the both were applied for the comorbidity model. Read More

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http://dx.doi.org/10.24920/003470DOI Listing
November 2018

Nontraumatic rupture of the costal margin: a single-center experience.

Asian Cardiovasc Thorac Ann 2019 Jan 15:218492318823367. Epub 2019 Jan 15.

Department of Thoracic Surgery, Nottingham University Hospitals, Nottingham, UK.

Background: Rupture of the costal margin is uncommon. Whilst most often seen after major trauma, we describe its occurrence in patients with no direct chest trauma.

Methods: A search was performed in our thoracic surgery database for all patients with rupture of the costal margin. Read More

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http://dx.doi.org/10.1177/0218492318823367DOI Listing
January 2019
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[Nursing intervention for respiratory function exercise in patients with silicosis complicated by stable chronic obstructive pulmonary disease].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):844-846

Affiliated laigang hospital of taishan medical college, Laiwu 271104 Sandong Pronince, China.

To investigate the clinical effect of nursing intervention for respiratory function exercise in patients with silicosis complicated by stable chronic obstructive pulmonary disease (COPD) . A total of 60 patients with silicosis complicated by stable COPD who were hospitalized in Department of Occupational Diseases, Laigang Hospital Affiliated to Taishan Medical College, from August 2017 to April 2018 were enrolled and randomly divided into control group and observation group, with 30 patients in each group. The patients in the control group were given routine treatment and respiratory function exercise, and those in the observation group were given nursing intervention in addition to the treatment in the control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.012DOI Listing
November 2018

Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease.

JAMA Netw Open 2018 Dec 7;1(8):e185489. Epub 2018 Dec 7.

Leicester Diabetes Centre, University of Leicester, Leicester, United Kingdom.

Importance: In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effect of COPD severity is unknown. This information is important for early intervention tailored to the highest-risk groups.

Objectives: To determine the associations between COPD medication intensity or stage of airflow limitation and the risk of hospitalization or death in patients with HF. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5489DOI Listing
December 2018
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Misclassification of Both Chronic Obstructive Pulmonary Disease and Heart Failure.

JAMA Netw Open 2018 Dec 7;1(8):e185486. Epub 2018 Dec 7.

Julius Center for Health Sciences and Primary Care, Department of General Practice, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5486DOI Listing
December 2018

Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease: A Randomized Clinical Trial.

JAMA Netw Open 2018 Sep 7;1(5):e181843. Epub 2018 Sep 7.

Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, Missouri.

Importance: Smokers with chronic obstructive pulmonary disease (COPD) have particular difficulty quitting. Long-term nicotine replacement therapy (LT-NRT) might offer a strategy for reducing harm from cigarettes and provide a pathway for later cessation.

Objective: To compare the effect of LT-NRT vs standard smoking cessation (SSC) on exposure to cigarette smoke, harm related to smoking, and cessation among smokers with COPD. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1843DOI Listing
September 2018
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Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission.

JAMA Netw Open 2018 Aug 3;1(4):e181405. Epub 2018 Aug 3.

Center of Innovation in Long Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island.

Importance: Delirium at admission is associated with increased hospital morbidity and mortality, but it may be missed in up to 70% of cases. Use of a predictive algorithm in an electronic medical record (EMR) system could provide critical information to target assessment of those with delirium at admission.

Objectives: To develop and assess a prediction rule for delirium using 2 populations of veterans and compare this rule with previously confirmed rules. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1405DOI Listing
August 2018
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Prevalence of and Factors Associated With Long-term Concurrent Use of Stimulants and Opioids Among Adults With Attention-Deficit/Hyperactivity Disorder.

JAMA Netw Open 2018 Aug 3;1(4):e181152. Epub 2018 Aug 3.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville.

Importance: There exist limited data on the long-term concurrent use of stimulants and opioids among adults with attention-deficit/hyperactivity disorder (ADHD), a population at risk for prescription drug abuse.

Objective: To assess the prevalence and secular trends of and the factors associated with long-term concurrent use of stimulants and opioids among adults with ADHD.

Design, Setting, And Participants: This cross-sectional study assessed Medicaid Analytic eXtract data from 29 states between 1999 and 2010. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1152DOI Listing

Impact of Matrix Metalloproteinase 9 on COPD Development in Polish Patients: Genetic Polymorphism, Protein Level, and Their Relationship with Lung Function.

Biomed Res Int 2018 10;2018:6417415. Epub 2018 Dec 10.

Institute of Physiotherapy, Faculty of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland.

Chronic obstructive pulmonary disease (COPD) is characterized by a decline of lung function and symptoms such as chronic bronchitis and emphysema leading from lung tissue destruction. Increased activity of matrix metalloproteinases (MMPs) and an imbalance between MMPs and their tissue inhibitors (TIMPs) are considered as factors influencing the pathogenesis of COPD. We investigated the role of genetic polymorphism and expression level of MMP-9 and concentration of its complexes with TIMPs in the development of COPD among Polish patients. Read More

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http://dx.doi.org/10.1155/2018/6417415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311264PMC
December 2018
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The relationship between steps of 6MWT and COPD severity: a cross-sectional study.

Int J Chron Obstruct Pulmon Dis 2019 28;14:141-148. Epub 2018 Dec 28.

Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China,

Background And Objective: The distance of 6-minute walk test (D6MWT) has been widely used in the assessment of functional status in patients with COPD, while very little attention has been paid to the role of steps of 6-minute walk test (S6MWT). The purpose of this study was to investigate the relationship between S6MWT and other physiologic parameters of COPD.

Patients And Methods: Seventy patients with stable COPD were enrolled consecutively in this cross-sectional study. Read More

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http://dx.doi.org/10.2147/COPD.S188994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312395PMC
December 2018