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    Predictive factors for early hospital readmission and 1-year mortality in elder patients following surgical treatment of a hip fracture.
    Ulus Travma Acil Cerrahi Derg 2017 May;23(3):245-250
    Department of Orthopedics and Traumatology, Erzincan University Faculty of Medicine, Erzincan-Turkey.
    Background: Early hospital readmission after surgically treated hip fracture is a common entity, often involving an adverse event and causing strains on an already overburdened healthcare system. The main purposes of the present study were to determine the 30-day readmission rate, analyze the predictive factors for early hospital readmissions, and assess 1-year mortality following surgical treatment of hip fracture in elderly patients. Retrospective case-control study. Read More

    [TREATMENT OF MECHANICALLY VENTILATED PATIENTS IN AN INTERNAL MEDICINE DEPARTMENT - OVERVIEW 2013].
    Harefuah 2016 Aug;155(8):482-484
    Department of Internal Medicine A, Barzilai Medical Center, Ashkelon, Ben Gurion University of the Negev.
    Background: Over recent years the number of mechanically ventilated patients in internal medicine departments has grown. These patients are elderly, mostly disabled and suffer from many chronic illnesses. Most of them require prolonged mechanical ventilation. Read More

    Combined Impact of Smoking and Early Life Exposures on Adult Lung Function Trajectories.
    Am J Respir Crit Care Med 2017 May 21. Epub 2017 May 21.
    Imperial College London, COPD Research Group, Airways Disease Section, National Heart and Lung Institute, London, United Kingdom of Great Britain and Northern Ireland ;
    Background: Both adverse early life exposures and adult smoking can negatively influence adult lung function trajectory but few studies consider how the impact of early life exposures may be modified by subsequent smoking.

    Methods: The Medical Research Council National Survey of Health and Development is a nationally representative cohort, initially of 5362 individuals, followed since enrolment at birth in March 1946. Using data collected prospectively across life and multilevel modelling we investigated how the relationships between early life exposures (infant lower respiratory infection, manual social class, home overcrowding and pollution exposure) and FEV1 and FVC trajectories between ages 43 and 60-64 were influenced by smoking behaviour. Read More

    Patients' and healthcare professionals' perceptions of self-management support interactions: Systematic review and qualitative synthesis.
    Chronic Illn 2017 Jan 1:1742395317710082. Epub 2017 Jan 1.
    4 Faculty of Pharmacy, The University of Sydney, Camperdown, NSW, Australia.
    Objective To review studies examining the experience of self-management support in patient-provider interactions and the shaping of goals through interactions. Methods We undertook a systematic review and thematic synthesis of the qualitative literature. We searched six databases (2004-2015) for published studies on the provision of self-management support in one-to-one, face-to-face, patient-provider interactions for obesity, type 2 diabetes mellitus and chronic obstructive pulmonary disease, with 14 articles meeting inclusion criteria. Read More

    [THE ASSOCIATION BETWEEN OBESITY AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)].
    Harefuah 2016 Sep;155(9):554-558
    Department of Medicine B, Ben-Gurion University, Soroka University Medical Center, Beer-Sheva, Israel.
    Background: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease, with major respiratory and systemic expressions. Obesity is defined as a BMI>30 kg/ m2 and its prevalence has doubled in recent decades. The possible relationship of obesity to COPD, and its influence on respiratory pathophysiology, is considered a mystery. Read More

    [LONG TERM TREATMENT WITH MACROLIDES IN CHRONIC LUNG DISEASES].
    Harefuah 2016 Sep;155(9):567-571
    Pulmonary Institute, Carmel Medical Center.
    Introduction: Macrolide agents have both antibacterial properties as well as various effects on the inflammatory system. In recent years there is growing evidence regarding the favourable effects of macrolides in a range of chronic respiratory conditions. Historically, erythromycin and clarithromycin were found to stabilize pulmonary deterioration in diffuse panbronchiolitis. Read More

    Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases.
    Theranostics 2017 7;7(6):1543-1588. Epub 2017 Apr 7.
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States.
    The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2 signaling axis is involved in the pathogenesis of several diseases including chronic obstructive pulmonary diseases (COPD), asthma, cystic fibrosis and cancer. Interaction between CXCL8 secreted by select cancer cells and CXCR1/2 in the tumor microenvironment is critical for cancer progression and metastasis. Read More

    Chronic obstructive pulmonary disease associated with increased risk of bipolar disorder.
    Chron Respir Dis 2017 May 1;14(2):151-160. Epub 2016 Jan 1.
    2 Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
    Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of chronic obstructive pulmonary disease (COPD). However, the relationship between COPD and subsequent bipolar disorder remains unclear. From January 1, 2000, we identified adult patients with COPD from the Taiwan National Health Insurance Research Database. Read More

    Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection.
    Inflammopharmacology 2017 May 20. Epub 2017 May 20.
    Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre, P. Debyelaan 25, 6229 HZ, Maastricht, The Netherlands.
    Patients with more severe chronic obstructive pulmonary disease frequently experience exacerbations and it is estimated that up to 50% of these exacerbations are associated with bacterial infections. The mainstay treatment for these infection-related exacerbations constitutes the administration of glucocorticoids, alone or in combination with antibiotics. A recent line of evidence demonstrates that many hormones including the steroid beclomethasone can also directly affect bacterial growth, virulence, and antibiotic resistance. Read More

    Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.
    JAMA 2017 May 21. Epub 2017 May 21.
    Lane Fox Unit, Guy's and St Thomas' NHS Foundation Trust, London, England2Asthma, Allergy, and Lung Biology, King's College London, London, England.
    Importance: Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there are few treatments to prevent hospital readmission and death.

    Objective: To investigate the effect of home NIV plus oxygen on time to readmission or death in patients with persistent hypercapnia after an acute COPD exacerbation.

    Design, Setting, And Participants: A randomized clinical trial of patients with persistent hypercapnia (Paco2 >53 mm Hg) 2 weeks to 4 weeks after resolution of respiratory acidemia, who were recruited from 13 UK centers between 2010 and 2015. Read More

    Emerging bronchoscopic treatments for chronic obstructive pulmonary disease.
    Pharmacol Ther 2017 May 17. Epub 2017 May 17.
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands.
    Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by pathophysiological factors including airflow limitation, hyperinflation and reduced gas exchange. Treatment consists of lifestyle changes, lung rehabilitation and pharmacological therapies such as long acting beta-2-agonists (LABA) and long acting muscarinic antagonists (LAMA). More recently bronchoscopic treatments are emerging for COPD. Read More

    Telehealth Interventions to Support Self-Management of Long-Term Conditions: A Systematic Metareview of Diabetes, Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, and Cancer.
    J Med Internet Res 2017 May 17;19(5):e172. Epub 2017 May 17.
    Allergy and Respiratory Research Group, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
    Background: Self-management support is one mechanism by which telehealth interventions have been proposed to facilitate management of long-term conditions.

    Objective: The objectives of this metareview were to (1) assess the impact of telehealth interventions to support self-management on disease control and health care utilization, and (2) identify components of telehealth support and their impact on disease control and the process of self-management. Our goal was to synthesise evidence for telehealth-supported self-management of diabetes (types 1 and 2), heart failure, asthma, chronic obstructive pulmonary disease (COPD) and cancer to identify components of effective self-management support. Read More

    The SENSOR Study: Protocol for a Mixed-Methods Study of Self-Management Checks to Predict Exacerbations of Pseudomonas Aeruginosa in Patients with Long-Term Respiratory Conditions.
    JMIR Res Protoc 2017 May 19;6(5):e89. Epub 2017 May 19.
    Department of Research and Innovation, Portsmouth Hospitals National Health Service Trust, Portsmouth, United Kingdom.
    Background: There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in COPD and severe asthma. Both COPD and bronchiectasis are characterized by exacerbations in which bacteria play a central role. Read More

    [Over-diagnosis of chronic obstructive pulmonary disease in Primary Care. Prevalence and determining factors].
    Semergen 2017 May 17. Epub 2017 May 17.
    Servicio de Neumología, Hospital Universitario Lucus Augusti, Lugo, España.
    Introduction: COPD under-diagnosis is common in Primary Health Care medicine, due to the low use of spirometry, but there is less information about over-diagnosis of the disease in patients that have a clinical diagnosis of COPD.

    Objective: The main objective of the study was to investigate the prevalence of COPD over-diagnosis in Primary Care medicine. Secondary objectives were to determine the factors associated with an incorrect clinical diagnosis of COPD and to analyse whether the pharmacological treatment is different for patients with correct or incorrect diagnosis. Read More

    A behaviour change intervention to reduce sedentary time in people with chronic obstructive pulmonary disease: protocol for a randomised controlled trial.
    J Physiother 2017 May 16. Epub 2017 May 16.
    Discipline of Physiotherapy, The University of Sydney.
    Introduction: Replacing sedentary behaviour with light intensity physical activity (ie, activities classified as less than three metabolic equivalents, such as slow-paced walking) may be a more realistic strategy for reducing cardiometabolic risk in people with chronic obstructive pulmonary disease than only aiming to increase levels of moderate-vigorous intensity physical activity. Behaviour change interventions to reduce sedentary behaviour in people with chronic obstructive pulmonary disease have not yet been developed or tested.

    Research Questions: Is a 6-week behaviour change intervention effective and feasible in reducing sedentary time in people with chronic obstructive pulmonary disease?

    Design: This study will be a multi-centre, randomised, controlled trial with concealed allocation, assessor blinding, and intention-to-treat analysis, comparing a 6-week behaviour change intervention aimed at reducing sedentary time with a sham intervention in people with chronic obstructive pulmonary disease. Read More

    The -786 T/C polymorphism of NOS3 gene is a susceptibility marker of COPD among Tunisians that correlates with nitric oxide levels and airflow obstruction.
    Cytokine 2017 May 16. Epub 2017 May 16.
    Unité de Recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire "Biologie, Medecine et Santé, Faculté de Medecine Ibn el Jazzar, Sousse, Tunisia; Département de Biologie, Faculté des Sciences de Sfax, Tunisia. Electronic address:
    Objective: The goal of this study was to examine the role of G894T (rs1799983), -786T/C (rs3918161) and a 27 bp variable number of tandem repeats (VNTR) 4B/4A of NOS3 gene on the risk and severity of COPD.

    Methods: The study included 194 controls and 138 COPD patients. NOS3 G894T, -786T/C and 4B/4A variants were determined by PCR analysis based on the banding pattern on gel electrophoresis. Read More

    Reduced HDAC2 in skeletal muscle of COPD patients.
    Respir Res 2017 May 19;18(1):99. Epub 2017 May 19.
    Airway Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK.
    Background: Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The aim of this study was to investigate the role of histone deacetylases(HDAC) in skeletal muscle weakness in COPD.

    Methods And Results: Twelve COPD patients, 8 smokers without COPD (SM) and 4 healthy non-smokers (NS) were recruited to the study. Read More

    Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection.
    J Cardiothorac Surg 2017 May 19;12(1):35. Epub 2017 May 19.
    Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
    Background: Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonary disease patients.

    Methods: We retrospectively analyzed 174 consecutive chronic obstructive pulmonary disease patients with non-small-cell lung cancer who underwent lobectomy or segmentectomy. Read More

    [Effect of esmolol on hemodynamics and clinical outcomes in patients with septic shock].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 May;29(5):390-395
    Department of Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China. Corresponding author: Li Gang, Email:
    Objective: To evaluate the effect of heart rate control with esmolol on hemodynamics, inflammatory cytokines and clinical outcomes in patients with septic shock.

    Methods: A prospective randomized controlled trial was conducted. The patients with septic shock admitted to Department of Critical Care Medicine of China-Japan Friendship Hospital from August 2014 to October 2016 were enrolled. Read More

    Why do patients decline participation in offered pulmonary rehabilitation? A qualitative study.
    Clin Rehabil 2017 May 1:269215517708821. Epub 2017 May 1.
    1 Department of Nursing, Metropolitan University College, Copenhagen, Denmark.
    Objective: The purpose of this study is to produce insight in the explanations for declining pulmonary rehabilitation given by patients with chronic obstructive pulmonary disease.

    Setting: The participants were recruited from a hospital in Denmark, among patients hospitalized due to an exacerbation of chronic obstructive pulmonary disease and among stable patients attending an outpatient clinic.

    Participants: Patients who decline participation in offered pulmonary rehabilitation, who speak Danish, who are able to give informed consent and to participate in a 1-hour interview. Read More

    Impact of a Patient Navigator Program on Hospital-Based and Outpatient Utilization Over 180 Days in a Safety-Net Health System.
    J Gen Intern Med 2017 May 18. Epub 2017 May 18.
    Harvard Medical School, Boston, MA, USA.
    Background: With emerging global payment structures, medical systems need to understand longer-term impacts of care transition strategies.

    Objective: To determine the effect of a care transition program using patient navigators (PNs) on health service utilization among high-risk safety-net patients over a 180-day period.

    Design: Randomized controlled trial conducted October 2011 through April 2013. Read More

    Respiratory bronchiolitis-associated interstitial lung disease - an unexpected form of idiopathic interstitial pneumonia in a young male.
    Rom J Morphol Embryol 2017 ;58(1):261-265
    Department of Pulmonology, Faculty of Medicine, "Ovidius" University of Constanta, Clinical Hospital of Pulmonology, Constanta, Romania;
    Cigarette smoking is the most frequently encountered risk factor for chronic obstructive pulmonary disease and lung cancer. The latest American Thoracic Society÷European Respiratory Society classification of idiopathic interstitial pneumonia includes two entities related to smoking habits: respiratory bronchiolitis-associated interstitial lung disease and desquamative interstitial pneumonia. The new approach to diagnosis is to combine pathological pattern with clinical and radiological data. Read More

    Roles of roflumilast, a selective phosphodiesterase 4 inhibitor, in airway diseases.
    J Thorac Dis 2017 Apr;9(4):1144-1154
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases. Both diseases have incompletely distinct pathophysiology, clinical manifestation, and treatment responsiveness. Pulmonary and systemic inflammations are the hallmarks of COPD. Read More

    Effect of azithromycin in combination with simvastatin in the treatment of chronic obstructive pulmonary disease complicated by pulmonary arterial hypertension.
    Pak J Med Sci 2017 Mar-Apr;33(2):260-264
    Zhixin Ding, Intensive Care Unit, Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou, 450007, China.
    Objective: To evaluate the effect of azithromycin in combination with simvastatin in the treatment of chronic obstructive pulmonary disease (COPD) complicated by pulmonary arterial hypertension.

    Methods: Eighty-six patients who developed COPD and pulmonary arterial hypertension and received treatment from August 2013 to October 2014 were selected and randomly divided into an observation group and a control group using random number table, 43 in each group. Patients in the control group were orally administrated 20 mg of simvastatin, once a day. Read More

    Physical activity and risk of comorbidities in patients with chronic obstructive pulmonary disease: a cohort study.
    NPJ Prim Care Respir Med 2017 May 18;27(1):36. Epub 2017 May 18.
    Epidemiology, Biostatistics, and Prevention Institute, University of Zurich, Hirschengraben 84, CH-8001, Zurich, Switzerland.
    Multi-morbidity is common in patients with chronic obstructive pulmonary disease and low levels of physical activity are hypothesized to be an important risk factor. The current study aimed to assess the longitudinal association between physical activity and risk of seven categories of comorbidity in chronic obstructive pulmonary disease patients. The study included 409 patients from primary care practice in the Netherlands and Switzerland. Read More

    How to determine an impaired health status in COPD: Results from a population-based study.
    Neth J Med 2017 May;75(4):151-157
    Department of Research & Education, CIRO, Horn, the Netherlands.
    Background: Chronic obstructive pulmonary disease (COPD) is associated with a significantly impaired health status and lost work productivity across all degrees of airflow limitation. The current study investigated whether an impaired health status is better represented by the recommended COPD Assessment Test (CAT) cut-point of 10 points, or the 95th percentile of the CAT score in a non-COPD population. Additionally, the impact of COPD on health status in a Dutch population, after stratification for work status, was measured. Read More

    Decreased phosphatase PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD.
    Am J Physiol Lung Cell Mol Physiol 2017 May 18:ajplung.00382.2016. Epub 2017 May 18.
    The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. Our aim was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway, in COPD. PTEN expression and activity were measured in the peripheral lung of COPD patients compared to smoking and non-smoking controls. Read More

    Genome-wide gene expression array identifies novel genes related to disease severity and excessive daytime sleepiness in patients with obstructive sleep apnea.
    PLoS One 2017 17;12(5):e0176575. Epub 2017 May 17.
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed gene expression profiles of peripheral blood mononuclear cells from 48 patients with sleep-disordered breathing stratified into four groups: primary snoring (PS), moderate to severe OSA (MSO), very severe OSA (VSO), and very severe OSA patients on long-term continuous positive airway pressure treatment (VSOC). Comparisons of the microarray gene expression data identified eight genes up-regulated with OSA and down-regulated with CPAP treatment, and five genes down-regulated with OSA and up-regulated with CPAP treatment. Read More

    The Relationship Between Weather and Objectively Measured Physical Activity Among Individuals With COPD.
    J Cardiopulm Rehabil Prev 2017 May 17. Epub 2017 May 17.
    University of Toronto, Ontario, Canada (Dr Balish); School of Physiotherapy (Dr Dechman) and Faculty of Medicine (Drs Hernandez and Blanchard), Dalhousie University, Halifax, Nova Scotia, Canada; Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada (Dr Spence); Behavioural Medicine Laboratory, University of Victoria, British Columbia, Canada (Dr Rhodes); School of Human Kinetics, Laurentian University, Sudbury, Ontario, Canada (Dr McGannon); and Capital District Health Authority, Halifax, Nova Scotia, Canada (Dr Blanchard).
    Purpose: Although daily variation in weather impacts physical activity (PA) levels among relatively healthy individuals, it is largely unknown whether this relationship occurs for those living with chronic obstructive pulmonary disease (COPD). The purpose of this study was to examine how daily variation in temperature, rain, and snow is related to objectively measured PA among patients with COPD, and whether demographic or clinical characteristics moderate these relationships.

    Methods: Patients with COPD completed a questionnaire and wore a pedometer for 7 days at baseline, end of pulmonary rehabilitation (PR), and 3 and 9 months after completing PR (28 days in total). Read More

    Respiratory functional status after conventional and minimally invasive aortic valve replacement surgery - a propensity score analysis.
    Kardiochir Torakochirurgia Pol 2017 Mar 31;14(1):5-9. Epub 2017 Mar 31.
    Department of Cardiovascular Surgery and Transplantation, Jagiellonian University, Pope John Paul II Krakow Specialist Hospital, Kraków, Poland.
    Introduction: Reports describing respiratory function of patients after conventional or minimally invasive cardiac surgery are infrequent.

    Aim: To compare pulmonary functional status after conventional (AVR) and after minimally invasive, through right anterior minithoracotomy, aortic valve replacement (RT-AVR).

    Material And Methods: This was an observational analysis of 212 patients scheduled for RT-AVR and 212 for AVR between January 2011 and December 2014 selected using propensity score matching. Read More

    Cost-effectiveness of telehealthcare to patients with chronic obstructive pulmonary disease: results from the Danish 'TeleCare North' cluster-randomised trial.
    BMJ Open 2017 May 17;7(5):e014616. Epub 2017 May 17.
    Danish Centre for Healthcare Improvements, Aalborg University, Aalborg, Denmark.
    Objectives: To investigate the cost-effectiveness of a telehealthcare solution in addition to usual care compared with usual care.

    Design: A 12-month cost-utility analysis conducted alongside a cluster-randomised trial.

    Setting: Community-based setting in the geographical area of North Denmark Region in Denmark. Read More

    Chronic obstructive pulmonary disease.
    Lancet 2017 May 11;389(10082):1931-1940. Epub 2017 May 11.
    Pulmonary Research Institute, Airway Research Centre North, German Centre for Lung Research, Grosshansdorf, Germany.
    Chronic obstructive pulmonary disease (COPD) kills more than 3 million people worldwide every year. Despite progress in the treatment of symptoms and prevention of acute exacerbations, few advances have been made to ameliorate disease progression or affect mortality. A better understanding of the complex disease mechanisms resulting in COPD is needed. Read More

    Flagellar expression in clinical isolates of non-typeable Haemophilus influenzae.
    J Med Microbiol 2017 May 18;66(5):592-600. Epub 2017 May 18.
    1​Benemérita Universidad Autónoma de Puebla, Instituto de Ciencias, Posgrado en Microbiología, Centro de Investigaciones en Ciencias Microbiológicas, Puebla, México.
    Purpose: Haemophilus influenzae is a commensal organism found in the upper respiratory tract of humans. When H. influenzae becomes a pathogen, these bacteria can move out of their commensal niche and cause multiple respiratory tract diseases such as otitis media, sinusitis, conjunctivitis and bronchitis in children, and chronic obstructive pulmonary disease in adults. Read More

    Do current OELs for silica protect from obstructive lung impairment? A critical review of epidemiological data.
    Crit Rev Toxicol 2017 May 17:1-28. Epub 2017 May 17.
    a Louvain Center for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain , Bruxelles , Belgium.
    Inhalation of respirable crystalline silica (RCS) can lead to serious health effects such as silicosis and lung cancer. There also seems to be a general consensus to consider that RCS exposure is associated with obstructive lung impairment or chronic obstructive pulmonary disease (COPD), a leading cause of mortality, morbidity, and disability worldwide. It is, however, not clear whether occupational exposure levels (OELs), generally set to prevent silicosis, also protect workers from developing an obstructive impairment. Read More

    Uptake of telehealth implementation for COPD patients in a high-poverty, inner-city environment: A survey.
    Chron Respir Dis 2017 Jan 1:1479972317707653. Epub 2017 Jan 1.
    3 Lane Fox Respiratory Unit, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
    This study aimed to investigate computer and internet access and education attained in patients with chronic obstructive pulmonary disease (COPD) as potential barriers to implementation of telemedicine. We prospectively assessed 98 patients admitted with an acute exacerbation of COPD (mean age: 70.5 ± 9. Read More

    Recognition of Small Airways Obstruction in Asthma and COPD - The Road Less Travelled.
    J Clin Diagn Res 2017 Mar 1;11(3):TE01-TE05. Epub 2017 Mar 1.
    Consultant, QRG Health City, Faridabad SR, Respiratory Medicine, VP Chest Institute, New Delhi, India.
    The small airways, once regarded as the silent zone in the air conducting system of the lungs are now known to be one of the initial sites of involvement in diseases like asthma and Chronic Obstructive Pulmonary Disease (COPD). Identification of the involvement of distal airways in these diseases is often difficult to assess, clinically as well as by conventional pulmonary function tests and therefore, usually remains undiscovered in early stages. Early recognition of their involvement in asthma and COPD and timely management may reduce long term morbidity in these conditions. Read More

    Clinico-Radiologic and Spirometric Profile of an Indian Population with Post-Tuberculous Obstructive Airway Disease.
    J Clin Diagn Res 2017 Mar 1;11(3):OC35-OC38. Epub 2017 Mar 1.
    Assistant Professor, Department of Pulmonary Medicine, V.S.S. Medical College, Burla, Sambalpur, Odisha, India.
    Introduction: Tuberculosis is a public health problem in developing countries and in spite of receiving adequate anti-tuberculous therapy, patients often continues to have several post-tuberculous sequelae, especially airflow limitation.

    Aim: To evaluate pulmonary function by spirometry among post-tuberculosis cases with airway obstruction and their relationship with smoking.

    Materials And Methods: All patients who presented to the pulmonary medicine Outpatient Department (OPD) with symptoms of obstructive airway disease and had completed adequate anti-tuberculous therapy for pulmonary tuberculosis were taken up for study. Read More

    Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease.
    Biomed Pharmacother 2017 May 12;91:925-930. Epub 2017 May 12.
    Department of Basic Nursing Science, School of Nursing, Korea University, Seoul 02841, Republic of Korea. Electronic address:
    Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that is generally characterized by progressive and irreversible airflow obstruction and alveolar destruction. Long-term treatment with current medications has been associated with various adverse effects, indicating a need for alternative approaches for the prevention and treatment of COPD. This study investigated the mechanism underlying the effects of trans-anethole in a mouse model of COPD induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS). Read More

    Age, gender, neck circumference, and Epworth sleepiness scale do not predict obstructive sleep apnea (OSA) in moderate to severe chronic obstructive pulmonary disease (COPD): The challenge to predict OSA in advanced COPD.
    PLoS One 2017 16;12(5):e0177289. Epub 2017 May 16.
    Department of Medicine, Pulmonary, Critical Care and Sleep Division, UC San Diego, San Diego, CA, United States of America.
    The combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is associated with substantial morbidity and mortality. We hypothesized that predictors of OSA among patients with COPD may be distinct from OSA in the general population. Therefore, we investigated associations between traditional OSA risk factors (e. Read More

    Chronic kidney disease: A likely underestimated component of multimorbidity in older patients with chronic obstructive pulmonary disease.
    Geriatr Gerontol Int 2017 May 16. Epub 2017 May 16.
    Unit of Geriatric and Respiratory Medicine, University Campus BioMedico, Rome, Italy.
    The coexistence of chronic kidney disease and chronic obstructive pulmonary disease, two age-related conditions, has important clinical and prognostic implications. Respiratory failure is associated with important changes in glomerular and tubulointerstitial function. In contrast, renal failure can affect lung function, mainly by adding a restrictive component or causing complications, such as uremic pulmonary edema and pleural effusion. Read More

    An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.
    Clin Exp Pharmacol Physiol 2017 May 15. Epub 2017 May 15.
    The University of Manchester; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
    Lymphocyte numbers are increased in the lungs of chronic obstructive pulmonary disease (COPD) patients. Phosphatidylinositol-3-kinase delta (PI3Kδ) is involved in lymphocyte activation. We investigated the effect of PI3Kδ inhibition on cytokine release from COPD lymphocytes. Read More

    Rehabilitation of Discharged Patients With Chronic Obstructive Pulmonary Disease-Are New Strategies Needed?
    Health Serv Res Manag Epidemiol 2017 Jan-Dec;4:2333392816687704. Epub 2017 Jan 12.
    Department for Regional Health Research, Centre for Quality, University of Southern Denmark, Odense, Denmark.
    Background: Rehabilitation after hospital stay implies several benefits for patients with chronic obstructive pulmonary disease (COPD); still few patients are referred and participate in rehabilitation programs. We conducted a case study to investigate the effects of interventions targeting the referral, uptake, and completion for a program of early rehabilitation in the primary health-care sector.

    Methods: We undertook targeted initiatives to make patients participate in an individualized rehabilitation program with gradual increased intensity. Read More

    Recurrent Stress Cardiomyopathy During COPD Exacerbation: Are Beta-adrenergic Agonists Only to Blame?
    Cureus 2017 Apr 14;9(4):e1166. Epub 2017 Apr 14.
    Cardiology, North Bronx Health Network Jacobi Medical Center.
    Takotsubo cardiomyopathy (TCM) is a variant of stress-induced cardiomyopathy, characterized by transient left ventricular dysfunction that may be associated with emotional or physical triggers. We present the case of a 51-year-old Caucasian female with severe chronic obstructive pulmonary disease (COPD) who presented with syncope and was found to have her second lifetime episode of stress-induced cardiomyopathy. Eight months prior, she had been admitted with a COPD exacerbation and was found to have left ventricular (LV) dysfunction with ejection fraction (EF) of 22% attributed to TCM with subsequent normalization of her left ventricular function. Read More

    Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease.
    Arch Med Sci 2017 Apr 20;13(3):645-651. Epub 2016 Jun 20.
    Department of Environmental Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
    Introduction: Butyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids. Butyrylcholinesterase activity is associated with both inflammation and oxidative stress. Changes in the activity of this enzyme have been observed in various diseases such as liver cirrhosis, diabetes, neurodegenerative disease and others. Read More

    The pharmacotherapy preferred by doctors in treatment of patients diagnosed with asthma or chronic obstructive pulmonary disease or allergic rhinitis and concomitant diseases: an epidemiological analysis.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):148-158. Epub 2017 Apr 13.
    Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
    Introduction: The clinical course of asthma and chronic obstructive pulmonary disease (COPD) is influenced by the co-occurrence of other chronic diseases and their pharmacotherapy. There are no data associated with the doctors' pharmacotherapy preferences in treatment of patients with asthma, COPD or allergic rhinitis and concomitant diseases.

    Aim: The assessment of doctors' preferences in pharmacotherapy of asthma, COPD or allergic rhinitis in relation to concomitant diseases. Read More

    Identifying individuals with physician-diagnosed chronic obstructive pulmonary disease in primary care electronic medical records: a retrospective chart abstraction study.
    NPJ Prim Care Respir Med 2017 May 15;27(1):34. Epub 2017 May 15.
    Institute of Health Policy, Management and Evaluation, University of Toronto, Dalla Lana School of Public Health, 155 College Street, Suite 425, Toronto, ON, M5T 3M6, Canada.
    Little is known about using electronic medical records to identify patients with chronic obstructive pulmonary disease to improve quality of care. Our objective was to develop electronic medical record algorithms that can accurately identify patients with obstructive pulmonary disease. A retrospective chart abstraction study was conducted on data from the Electronic Medical Record Administrative data Linked Database (EMRALD(®)) housed at the Institute for Clinical Evaluative Sciences. Read More

    Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.
    J Biol Chem 2017 May 15. Epub 2017 May 15.
    University College Dublin, Ireland;
    CO2 is a physiological gas normally produced in the body during aerobic respiration. Hypercapnia (elevated blood pCO2 > ≈ 50mmHg) is a feature of several lung pathologies e.g. Read More

    Neutrophil Extracellular Traps are associated with disease severity and microbiota diversity in Chronic Obstructive Pulmonary Disease.
    J Allergy Clin Immunol 2017 May 12. Epub 2017 May 12.
    Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland. Electronic address:
    Background: Neutrophil extracellular traps (NETs) have been observed in the airway in COPD, but their clinical and pathophysiological implications have not been defined.

    Objective: To determine if NETs are associated with disease severity in COPD, and how they are associated with microbiota composition and airway neutrophil function.

    Methods: NET protein complexes (DNA-Elastase and Histone-Elastase complexes), cell free DNA and neutrophil biomarkers were quantified in soluble sputum and serum from COPD patients during periods of disease stability and during exacerbations, and compared to clinical measures of disease severity and sputum microbiome. Read More

    [The role of extracorporeal removal of CO2 (ECCO2R) in the management of respiratory diseases].
    Rev Mal Respir 2017 May 12. Epub 2017 May 12.
    Service de réanimation médicale, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
    Introduction: The aim of extracorporeal removal of CO2 (ECCO2R) is to ensure the removal of CO2 without any significant effect on oxygenation. ECCO2R makes use of low to moderate extracorporeal blood flow rates, whereas extracorporeal membrane oxygenation (ECMO) requires high blood flows.

    State Of The Art: For each ECCO2R device it is important to consider not only performance in terms of CO2 removal, but also cost and safety, including the incidence of hemolysis and of hemorrhagic and thrombotic complications. Read More

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