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    Interspecies diversity of chloride channel regulators, calcium-activated 3 genes.
    PLoS One 2018 18;13(1):e0191512. Epub 2018 Jan 18.
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
    Members of the chloride channel regulators, calcium-activated (CLCA) family, have been implicated in diverse biomedical conditions, including chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, the activation of macrophages, and the growth and metastatic spread of tumor cells. Several observations, however, could not be repeated across species boundaries and increasing evidence suggests that select CLCA genes are particularly prone to dynamic species-specific evolvements. Here, we systematically characterized structural and expressional differences of the CLCA3 gene across mammalian species, revealing a spectrum of gene duplications, e. Read More

    Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence.
    PLoS One 2018 18;13(1):e0191330. Epub 2018 Jan 18.
    Trinity Centre for Bioengineering, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
    Asthma and chronic obstructive pulmonary disease (COPD) patients are required to inhale forcefully and deeply to receive medication when using a dry powder inhaler (DPI). There is a clinical need to objectively monitor the inhalation flow profile of DPIs in order to remotely monitor patient inhalation technique. Audio-based methods have been previously employed to accurately estimate flow parameters such as the peak inspiratory flow rate of inhalations, however, these methods required multiple calibration inhalation audio recordings. Read More

    Effects of 1,25-Dihydroxyvitamin D3 on the Prevention of Chronic Obstructive Pulmonary Disease (COPD) in Rats Exposed to Air Pollutant Particles Less than 2.5 Micrometers in Diameter (PM2.5).
    Med Sci Monit 2018 Jan 18;24:356-362. Epub 2018 Jan 18.
    Department of Thoracic Surgery, Jiangxi Provincial Chest Hospital, Nanchang, Jiangxi, China (mainland).
    BACKGROUND This study aimed to investigate the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on airway changes in chronic obstructive pulmonary disease (COPD) rats exposed to air pollutant particles less than 2.5 micrometers in diameter (PM2.5), and to evaluate the mechanisms. Read More

    Performance of the LACE index to predict 30-day hospital readmissions in patients with chronic obstructive pulmonary disease.
    Clin Epidemiol 2018 27;10:51-59. Epub 2017 Dec 27.
    Department of Respiratory Medicine, Liverpool Hospital.
    Background And Objective: Patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (COPD) have a high 30-day hospital readmission rate, which has a large impact on the health care system and patients' quality of life. The use of a prediction model to quantify a patient's risk of readmission may assist in directing interventions to patients who will benefit most. The objective of this study was to calculate the rate of 30-day readmissions and evaluate the accuracy of the LACE index (length of stay, acuity of admission, co-morbidities, and emergency department visits within the last 6 months) for 30-day readmissions in a general hospital population of COPD patients. Read More

    Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients.
    Int J Chron Obstruct Pulmon Dis 2018 28;13:141-148. Epub 2017 Dec 28.
    Department of Pulmonary Medicine, Bellvitge University Hospital, IDIBELL, University of Barcelona, L'Hospitalet de Llobregat.
    Background: A higher risk of atherothrombotic cardiovascular events, which are platelet-driven processes, has been described during acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, the relevance of platelet reactivity during AECOPD and whether this is affected by antiplatelet agents are not fully elucidated to date. This study aimed to evaluate whether platelet reactivity is augmented during an exacerbation in COPD patients with and without antiplatelet therapy and its association with systemic inflammatory parameters. Read More

    Risk factors predict frequent hospitalization in patients with acute exacerbation of COPD.
    Int J Chron Obstruct Pulmon Dis 2018 27;13:121-129. Epub 2017 Dec 27.
    Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University.
    Purpose: COPD is a heterogeneous disease, and the available prognostic indexes are therefore limited. This study aimed to identify the factors associated with acute exacerbation leading to hospitalization.

    Patients And Methods: This was a retrospective study of consecutive patients with COPD (meeting the Global Initiative for Chronic Obstructive Lung Disease [GOLD] diagnostic criteria) hospitalized at the Ninth Hospital of Xi'an Affiliated Hospital of Xi'an Jiaotong University between October 2014 and September 2016. Read More

    Qualitative systematic review of barriers and facilitators to self-management of chronic obstructive pulmonary disease: views of patients and healthcare professionals.
    NPJ Prim Care Respir Med 2018 Jan 17;28(1). Epub 2018 Jan 17.
    Institute of Health and Society, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, USA.
    Self-management interventions for chronic obstructive pulmonary disease (COPD) can improve quality of life, reduce hospital admissions, and improve symptoms. However, many factors impede engagement for patients and practitioners. Qualitative research, with its focus on subjective experience, can provide invaluable insights into such factors. Read More

    Identifying COPD patients at risk for worse symptoms, HRQoL, and self-efficacy: A cluster analysis.
    Chronic Illn 2018 Jan 1:1742395317753883. Epub 2018 Jan 1.
    1 Department of Physical Therapy, Medical School, 37884 University of São Paulo, São Paulo, Brazil.
    Objectives To identify clusters of chronic obstructive pulmonary disease (COPD) patients with distinct beliefs about their illness in terms of symptoms, health-related quality of life (HRQoL), self-efficacy, and daily life physical activity (DLPA). Methods This cross-sectional study included 150 COPD outpatients. The patients' illness perceptions, clinical control, HRQoL, self-efficacy, and DLPA (accelerometry) were evaluated. Read More

    [A study on the effects and safety of sequential humidified high flow nasal cannula oxygenation therapy on the COPD patients after extubation].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):109-112
    Emergency Center, First Affiliated Hospital of Zhejiang University, Hangzhou 321000, China.
    Objective: To investigate and compare the effect and safety of nasal high-flow oxygen therapy (HFNCO) and noninvasive ventilation (NIV) therapy after extubation in patients with chronic obstructive pulmonary disease (COPD). Methods: All COPD patients subjected to mechanical ventilation in the Emergency Intensive Unit of the First Affiliated Hospital of Zhejiang University during January 2015 to June 2016 were included in the study. The patients were divided into two groups after extubation and HFNCO and NIV were adopted on each group respectively. Read More

    Impact of Air Pollution and Outdoor Temperature on the Rate of Chronic Obstructive Pulmonary Disease Exacerbations.
    Folia Med (Plovdiv) 2017 Dec;59(4):423-429
    1Clinic of Pneumonology and Phthisiatry, Dr. G. Stranski University Hospital, Pleven, Bulgaria.
    Background: Environmental pollution can be one of the main risk factors for acute exacerbations of chronic obstructive pulmonary disease (COPD).

    Aim: To study the relationship between air pollution, outdoor temperature and exacerbations of COPD.

    Materials And Methods: COPD patients (n=1432) were followed up for one year. Read More

    Comparison of respiratory system impedance in asthma and COPD: A prospective observational study.
    Respirology 2018 Jan 17. Epub 2018 Jan 17.
    Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe, Japan.
    Background And Objective: A single assessment of within-breath variations of respiratory system reactance (Xrs) at 5 Hz (ΔX5) measured by the forced oscillation technique (FOT) has been reported to be useful for the detection of pathophysiological changes in chronic obstructive pulmonary disease (COPD) and asthma. We examined longitudinal changes in respiratory system resistance (Rrs) and Xrs during tidal breathing between stable asthma and COPD patients in order to clarify the features of changes of respiratory system impedance and airflow limitation for these conditions.

    Methods: Between April 2013 and September 2013, outpatients with a COPD or asthma diagnosis were recruited. Read More

    Risk factors for osteoporosis in male patients with chronic obstructive pulmonary disease in Taiwan.
    PeerJ 2018 12;6:e4232. Epub 2018 Jan 12.
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Puzi City, Chiayi County, Taiwan.
    Objective: To investigate the risk factors for osteoporosis in male Taiwanese patients with chronic obstructive pulmonary disease (COPD).

    Methods: This cross-sectional study evaluated male COPD outpatients and age-matched male subjects at a regional teaching hospital. The following data were obtained and analyzed: bone mineral density of the lumbar spine and hip on dual-energy X-ray absorptiometry, demographic characteristics, questionnaire interview results, pulmonary function test results, chest posterior-anterior radiographic findings, and biochemical and high-sensitivity C-reactive protein (hs-CRP) levels. Read More

    Human airway branch variation and chronic obstructive pulmonary disease.
    Proc Natl Acad Sci U S A 2018 Jan 16. Epub 2018 Jan 16.
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
    Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. Read More

    HIF1A rs10873142 polymorphism is associated with risk of chronic obstructive pulmonary disease in a Chinese Han population: a case-control study.
    Biosci Rep 2018 Jan 16. Epub 2018 Jan 16.
    The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
    Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow. Recently, variants in the hypoxia-inducible factor 1α ( HIF1A ) gene were found to be associated with COPD risk. This study aimed to identify whether rs10873142 polymorphism (an intronic polymorphism) in HIF1A gene was related to COPD in a Chinese population. Read More

    Addressing the Impact and Unmet Needs of Nonadherence in Asthma and Chronic Obstructive Pulmonary Disease: Where Do We Go From Here?
    J Allergy Clin Immunol Pract 2018 Jan 12. Epub 2018 Jan 12.
    Department of General Practice, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands.
    Nonadherence to treatment, and its associated health and economic burden, is particularly problematic in asthma and chronic obstructive pulmonary disease management because of heterogeneous patient populations and the need for an inhaled route of drug administration. Symptom variability, comorbidities, and device switching further add to suboptimal adherence rates. As opposed to controlled clinical trials, real-life studies show consistently low inhaler adherence in daily practice, yet exact adherence rates have long been affected by disagreement on standardized definitions. Read More

    Asthma-COPD overlap: A Portuguese survey.
    Rev Port Pneumol (2006) 2018 Jan 12. Epub 2018 Jan 12.
    Pulmonology Department, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine, University of Porto, Portugal.
    Introduction: The overlap between asthma and chronic obstructive pulmonary disease (COPD) (ACO) has been discussed for many years but clinical recommendations for this entity have been diverse. This study is intended to reach a consensus on diagnosis, treatment and patient orientation for ACO, within the Portuguese medical community.

    Methods: This study was conducted by a multidisciplinary panel of experts from three distinct medical specialties (Pulmonology, Family Medicine and Immunoallergology). Read More

    Exhaled Air Molecules and Chronic Obstructive Pulmonary Disease.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec;39(6):841-845
    Department of Respiratory Medicine,Jiangxi Province People's Hospital,Nanchang 330006,China.
    Chronic airway inflammation,a main pathologic process of chronic obstructive pulmonary disease (COPD),can trigger inflammation cells and airway structure cells to produce bioactive molecules,which play key roles in the pathogenesis of COPD and are also an efficient indicators for the diagnosis and treatment of COPD. This article reviews the important roles of these exhaled air molecules in the diagnosis and treatment of COPD,with an attempt to offer new strategies in the management of COPD. Read More

    Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes.
    Respir Res 2018 Jan 16;19(1):10. Epub 2018 Jan 16.
    Radboud University Medical Center, Nijmegen, Netherlands.
    Background: Inhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in handling that can significantly reduce drug delivery to the lungs and effectiveness of treatment.

    Methods: A systematic review was conducted to define 'critical' errors and their impact on health outcomes and resource use between 2004 and 2016, using key search terms for inhaler errors in asthma and COPD (Search-1) and associated health-economic and patient burden (Search-2). Read More

    The chronic ischaemic cardiovascular disease ESC Pilot Registry: Results of the six-month follow-up.
    Eur J Prev Cardiol 2018 Jan 1:2047487317751955. Epub 2018 Jan 1.
    16 EURObservational Research Programme, European Society of Cardiology, France.
    Aim Chronic ischaemic cardiovascular disease (CICD) remains a leading cause of morbidity and mortality worldwide. The CICD Pilot Registry enrolled 2420 patients across 10 European Society of Cardiology countries prospectively to describe characteristics, management strategies and clinical outcomes in this setting. We report here the six-month outcomes. Read More

    Comparison of the in vitro pharmacological profiles of long-acting muscarinic antagonists in human bronchus.
    Pulm Pharmacol Ther 2018 Jan 11. Epub 2018 Jan 11.
    Laboratory of Research in Respiratory Pharmacology-UPRES EA220, UFR Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin, Université Paris-Saclay, Suresnes, France; Department of Airway Diseases, Hôpital Foch, Suresnes, France. Electronic address:
    Background And Purpose: Long-acting muscarinic antagonists (LAMAs) have been recommended for the treatment of chronic obstructive pulmonary disease and (more recently) asthma. However, the in vitro pharmacological profiles of the four LAMAs currently marketed (tiotropium, umeclidinium, aclidinium and glycopyrronium) have not yet been compared (relative to ipratropium) by using the same experimental approach.

    Experimental Approach: With a total of 560 human bronchial rings, we investigated the antagonists' potency, onset and duration of action for inhibition of the contractile response evoked by electrical field stimulation. Read More

    Chronic Lung Disease and Mortality after Cardiac Surgery: A Prospective Cohort Study.
    J Cardiothorac Vasc Anesth 2017 Dec 11. Epub 2017 Dec 11.
    Department of Cardiac Surgery, Meshalkin National Medical Research Centre, Novosibirsk, Russia.
    Objective: To investigate the 1-year survival in cardiac surgical patients with lung disease, including previously undiagnosed cases.

    Design: Prospective cohort study.

    Setting: Tertiary hospital. Read More

    Discontinuous ventilator weaning of patients with acute SCI.
    Spinal Cord 2018 Jan 16. Epub 2018 Jan 16.
    Centre for Spinal Injuries, BG Trauma Hospital Hamburg, Hamburg, Germany.
    Study Design: Retrospective, single centre cohort study.

    Objectives: To determine factors associated with ventilator weaning success and failure in patients with acute spinal cord injury (SCI); determine length of time and attempts required to wean from the ventilator successfully and determine the incidence of pneumonia.

    Setting: BG Klinikum Hamburg, Level 1 trauma centre, SCI Department, Germany. Read More

    Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease.
    Hum Genomics 2018 Jan 15;12(1). Epub 2018 Jan 15.
    Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.
    Background: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD). However, many genetic variants show suggestive evidence for association but do not meet the strict threshold for genome-wide significance. Integrative analysis of multiple omics datasets has the potential to identify novel genes involved in disease pathogenesis by leveraging these variants in a functional, regulatory context. Read More

    COPD management by Swedish general practitioners - baseline results of the PRIMAIR study.
    Scand J Prim Health Care 2018 Jan 15:1-9. Epub 2018 Jan 15.
    a NVS, Section for Family Medicine and Primary Care , Karolinska Institutet , Stockholm , Sweden.
    Background: Chronic obstructive pulmonary disease (COPD) is a common cause of suffering and death. Evidence-based management of COPD by general practitioners (GPs) is crucial for decreasing the impact of the disease. Efficient strategies include early diagnosis, smoking cessation and multimodal treatment. Read More

    Frailty: A global measure of the multisystem impact of COPD.
    Chron Respir Dis 2018 Jan 1:1479972317752763. Epub 2018 Jan 1.
    1 School of Healthcare Sciences, Cardiff University, University Hospital of Wales, Cardiff, UK.
    Chronic obstructive pulmonary disease (COPD) is a multisystem disease that resembles the accumulation of multiple impairments seen in aging. A comprehensive geriatric assessment (CGA) captures multisystem deficits, from which a frailty index (FI) can be derived. We hypothesized that patients with COPD would be frailer than a comparator group free from respiratory disease. Read More

    Statins in the treatment of COPD and asthma-where do we stand?
    Curr Opin Pharmacol 2018 Jan 12;40:26-33. Epub 2018 Jan 12.
    Department of Thoracic Medicine and Surgery at the Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
    Asthma and chronic obstructive pulmonary disease (COPD) are the two most prevalent obstructive lung diseases that account for tremendous morbidity and mortality throughout the world. These diseases have strong inflammatory components, with multiple prior studies showing elevated levels of various inflammatory markers and cells in those with COPD and asthma. Therefore, efforts to target inflammation in management of these diseases are of great interest. Read More

    Surrogate scale for evaluating respiratory function based on complete blood count parameters.
    J Clin Lab Anal 2018 Jan 15. Epub 2018 Jan 15.
    College of Medical Laboratory, Dalian Medical University, Dalian, China.
    Background: In this study, we aimed to identify a simple method for evaluating respiratory function using complete blood count parameters.

    Methods: The complete blood count parameters, including red blood cell (RBC) count, hemoglobin (Hb) level, lymphocyte (Lym) and platelet (Plt) count, and partial pressure of oxygen (PO2 ) level, were measured using automated analyzers in patients with chronic obstructive pulmonary disease (COPD), aged subjects, and young subjects (control group). The red cell index (RCI) was calculated using the following equation: (RBC × Hb)/(Lym × Plt); in theory, the RCI is inversely proportional to the respiratory function. Read More

    Examining patterns of multimorbidity, polypharmacy and risk of adverse drug reactions in chronic obstructive pulmonary disease: a cross-sectional UK Biobank study.
    BMJ Open 2018 Jan 14;8(1):e018404. Epub 2018 Jan 14.
    General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
    Objective: This study aims: (1) to describe the pattern and extent of multimorbidity and polypharmacy in UK Biobank participants with chronic obstructive pulmonary disease (COPD) and (2) to identify which comorbidities are associated with increased risk of adverse drug reactions (ADRs) resulting from polypharmacy.

    Design: Cross-sectional.

    Setting: Community cohort. Read More

    Relationship of sleep pattern and snoring with chronic disease: findings from a nationwide population-based survey.
    Sleep Health 2018 Feb 20;4(1):40-48. Epub 2017 Nov 20.
    BRAC Research and Evaluation Division, BRAC Centre, 75 Mohakhali, Dhaka 1212, Bangladesh. Electronic address:
    Objectives: To investigate the association of total sleep time and presence or absence of snoring with chronic disease among the Bangladeshi adult population.

    Design: Cross-sectional survey.

    Setting: Urban and rural Bangladesh. Read More

    Initial airflow obstruction in new cases of pulmonary tuberculosis: Complication, comorbidity or missed?
    Indian J Tuberc 2018 Jan 9;65(1):63-69. Epub 2017 Apr 9.
    Department of Tuberculosis and Pulmonology, Shupik National Medical Academy of Postgraduate Education, Kyiv, Ukraine.
    Tuberculosis (TB) may have a similar spirometry findings as a chronic obstructive pulmonary disease but the prevalence of TB-induced airflow obstruction (AO) is still unknown.

    Objectives: To measure frequency of AO in new TB cases at the beginning of treatment and to evaluate factors associated with obstructive abnormalities following TB diagnosis.

    Materials And Methods: 317 patients that have no history of prior AO were recruited into the study with a median age of 39. Read More

    [Not all exacerbations of chronic obstructive pulmonary disease should be treated with antibiotics].
    Ugeskr Laeger 2017 Apr;179(15)
    This review gives an update on antibiotic treatment of exacerbation of chronic obstructive pulmonary disease (COPD). Patients who do not need hospital admission and do not present with purulent sputum nor increased levels of C reactive protein/procalcitonin have no beneficial effect of antibiotic treatment. Those with severe COPD and increased sputum purulence should be treated with antibiotics, and first-line treatment should be amoxicillin, which is effective against the most common types of bacteria in COPD exacerbation. Read More

    The Role of Tiotropium+Olodaterol Dual Bronchodilator Therapy in the Management of Chronic Obstructive Pulmonary Disease.
    Tuberc Respir Dis (Seoul) 2018 Jan;81(1):13-18
    Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK.
    Bronchodilator therapy is central to the management of chronic obstructive pulmonary disease and are recommended as the preferred treatment by the Global Obstructive Lung Disease Initiative (GOLD). Long acting anti-muscarinics (LAMA) and long acting β₂ agonists (LABA) are both more effective than regular short-acting drugs but many patients remain symptomatic despite monotherapy with these drugs. Combination therapy with LAMA and LABA increases the therapeutic benefit while minimizing dose-dependent side effects of long-acting bronchodilator therapy. Read More

    Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP.
    Int Immunopharmacol 2018 Jan 10;56:36-42. Epub 2018 Jan 10.
    Faculty of Pharmacy, Tanta University, Tanta, El-Gharbia 31527, Egypt. Electronic address:
    Background: Roflumilast (Rof), a phosphodiesterase 4 (PDE4) inhibitor, has been shown to be an effective agent in inflammatory diseases and marketed for chronic obstructive pulmonary disease.

    Objective: This study was conducted to examine the potential anti-inflammatory effects of Rof in dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in rats and to investigate the molecular mechanisms underlying these effects.

    Methods: Forty male Wistar rats were divided into four groups: normal control, colitis group (rats received 5% DSS in their drinking water continuously for 7 days), Rof group, and sulfasalazine (SLZ) group. Read More

    Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials.
    Lancet Respir Med 2018 Jan 10. Epub 2018 Jan 10.
    Global Medical Affairs, AstraZeneca, Molndal, Sweden.
    Background: The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD. Read More

    Prediction of mortality in patients with chronic obstructive pulmonary disease with the new Global Initiative for Chronic Obstructive Lung Disease 2017 classification: a cohort study.
    Lancet Respir Med 2018 Jan 10. Epub 2018 Jan 10.
    Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
    Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification separates the spirometric 1-4 staging from the ABCD groups defined by symptoms and exacerbations. Little is known about how this new classification predicts mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to establish the predictive ability of the GOLD 2017 classification, compared with earlier classifications, for all-cause and respiratory mortality, both when using its main ABCD groups and when further subdividing according to spirometric 1-4 staging. Read More

    Correlation of severity of chronic obstructive pulmonary disease with potential biomarkers.
    Immunol Lett 2018 Jan 9. Epub 2018 Jan 9.
    Department of Community Medicine and Public Health, King George Medical University, Lucknow, Uttar Pradesh, 226003, India.
    Background: Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha (TNF-a). The present study was designed to assess the serum cytokines [Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)] levels in chronic obstructive pulmonary disease (COPD) patients and they were correlated with severity of disease by spirometric measurements. Read More

    PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway.
    Part Fibre Toxicol 2018 Jan 12;15(1). Epub 2018 Jan 12.
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No. 1, Sec 1, Ren-Ai Road, Taipei, Taiwan.
    Background: Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of air pollution that damages lung cells. However, the mechanisms remain to be elucidated. Read More

    Early occurrence of inspiratory muscle weakness in Parkinson's disease.
    PLoS One 2018 12;13(1):e0190400. Epub 2018 Jan 12.
    Department of Neurology and Movement Disorders, Lille University Medical Center, Lille, France.
    Introduction: In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of patients with advanced PD. The objective of the present study was to characterize lung function (under off-drug conditions) in early-stage PD patients at baseline and then again two years later. Read More

    Whole-genome methylation profiling of peripheral blood mononuclear cell for acute exacerbations of chronic obstructive pulmonary disease treated with corticosteroid.
    Pharmacogenet Genomics 2018 Jan 10. Epub 2018 Jan 10.
    Institute of Medical Sciences, Tzu Chi University, Hualian, Taiwan.
    Objective: Although association studies in the general population may be relevant for determining susceptibility to chronic obstructive pulmonary disease (COPD), they may be less applicable for pharmacogenetics research in participants who have already acquired the disease.

    Patients And Methods: A genome-wide methylation profiling (generated by HumanMethylation450 BeadChips study was performed on peripheral blood mononuclear cells of 24 patients with AECOPD (acute exacerbation COPD), with good and poor responsiveness to standard corticosteroid treatment. Pyrosequencing was used to replicate the selected CpG sites in 50 patients with AECOPD with standard corticosteroid treatment. Read More

    Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers.
    Ann Am Thorac Soc 2018 Jan 12. Epub 2018 Jan 12.
    University of Pittsburgh, Division of Pulmonary, Allergy & Critical Care Medicine , 3471 Fifth Avenue , Suite 1211 Kaufmann Building , Pittsburgh, Pennsylvania, United States , 15213 ;
    Rationale: Osteoporosis is common in individuals with chronic obstructive pulmonary disease. Lung-specific factors, including radiographic emphysema, independently associate with low bone mineral density (BMD) in cross-sectional smoking cohorts. However, factors associated with progressive bone loss in smokers are under-studied and largely unknown. Read More

    High risk endovascular aneurysm repair: a case report.
    J Perioper Pract 2017 Oct;27(10):234-235
    University College Hospital London, UK.
    Mr AB is a 66-year old gentleman who presented for elective endovascular aneurysm repair (EVAR) following a routine screening scan identifying a 5.5cm abdominal aortic aneurysm (AAA). He had a past history of chronic obstructive pulmonary disease (COPD) with FEV1/FVC ratio of 48% on pre-assessment. Read More

    Prognostic significance of hypoxia inducible factor-1α expression in patients with clear cell renal cell carcinoma.
    Mol Med Rep 2018 Jan 9. Epub 2018 Jan 9.
    Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
    The prognostic significance of hypoxia inducible factor-1α (HIF-1α) expression in tumors and the levels of preoperative hemoglobin in clear cell renal cell carcinoma (ccRCC), with or without concomitant chronic obstructive pulmonary disease (COPD), was investigated. A total of 128 patients with ccRCC who underwent surgery were analyzed using retrospective methods. Overall survival (OS) and progression free survival (PFS) were analyzed with clinicopathological variables, including preoperative hemoglobin levels, COPD and the levels of HIF‑1α expression, by Kaplan‑Meier survival analysis. Read More

    METABOLIC PROFILE OF SERUM FATTY ACIDS IN PATIENTS WITH COMORBIDITY OF CHRO-NIC OBSTRUCTIVE PULMONARY DISEASE AND CHRONIC PANCREATITIS.
    Georgian Med News 2017 Dec(273):56-60
    Kharkiv National Medical University; Municipal Health Care Institution"Kharkiv City Perinatal Center", Ukraine.
    Objective - study of blood serum fatty acid metabolic profile in patients with comorbidity of COPD and chronic pancreatitis. 238 patients were examined, of them 131 with combined COPD and chronic pancreatitis and 107 with isolated COPD run. In study of fatty acid spectrum biological materials were prepared and gas chromatography analysis of blood serum lipid fatty acid spectrum performed according to methodology by L. Read More

    Cigarette Smoke Increases Endothelial CXCL16-Leukocyte CXCR6 Adhesion In Vitro and In Vivo. Potential Consequences in Chronic Obstructive Pulmonary Disease.
    Front Immunol 2017 13;8:1766. Epub 2017 Dec 13.
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain.
    Cardiovascular disease (CVD) is a major comorbidity in chronic obstructive pulmonary disease (COPD). Although the mechanism of its development remains largely unknown, it appears to be associated with cigarette consumption and reduced lung function. Therefore, the aim of this study was to investigate the potential link between water-soluble cigarette smoke extract (CSE)-induced endothelial dysfunction and the function of CXCL16/CXCR6 axis on the initial attachment of leukocytes, in addition to its possible impact on COPD-associated systemic inflammation. Read More

    First Time Isolation of Mycobacterium hassiacum From a Respiratory Sample.
    Clin Med Insights Circ Respir Pulm Med 2018 3;12:1179548417747529. Epub 2018 Jan 3.
    Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
    We describe the first isolation of Mycobacterium hassiacum, a rapid-growing, partial acid-resistant mycobacterium, in a respiratory specimen from a patient with exacerbated chronic obstructive pulmonary disease. To provide therapeutic recommendation for future cases, antibiotic susceptibility testing of 3 clinical isolates was performed by broth microdilution. All strains tested showed susceptibility to clarithromycin, imipenem, ciprofloxacin, and doxycycline. Read More

    Clinical and inflammatory phenotyping by breathomics in chronic airway diseases irrespective of the diagnostic label.
    Eur Respir J 2018 Jan 11;51(1). Epub 2018 Jan 11.
    Dept of Respiratory Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
    Asthma and chronic obstructive pulmonary disease (COPD) are complex and overlapping diseases that include inflammatory phenotypes. Novel anti-eosinophilic/anti-neutrophilic strategies demand rapid inflammatory phenotyping, which might be accessible from exhaled breath.Our objective was to capture clinical/inflammatory phenotypes in patients with chronic airway disease using an electronic nose (eNose) in a training and validation set. Read More

    Program of Integrated Care for Patients with Chronic Obstructive Pulmonary Disease and Multiple Comorbidities (PIC COPD+): a randomised controlled trial.
    Eur Respir J 2018 Jan 11;51(1). Epub 2018 Jan 11.
    Medical Health Service, Michael Garron Hospital, Toronto, ON, Canada.
    We sought to evaluate the effectiveness of a multi-component, case manager-led exacerbation prevention/management model for reducing emergency department visits. Secondary outcomes included hospitalisation, mortality, health-related quality of life, chronic obstructive pulmonary disease (COPD) severity, COPD self-efficacy, anxiety and depression.Two-centre randomised controlled trial recruiting patients with ≥2 prognostically important COPD-associated comorbidities. Read More

    Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years.
    Thorax 2018 Jan 11. Epub 2018 Jan 11.
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
    Background: Cigarette smoking is the strongest risk factor for COPD. Smoking burden is frequently measured in pack-years, but the relative contribution of cigarettes smoked per day versus duration towards the development of structural lung disease, airflow obstruction and functional outcomes is not known.

    Methods: We analysed cross-sectional data from a large multicentre cohort (COPDGene) of current and former smokers. Read More

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