1,258,462 results match your criteria Chronic Myeloid Leukemia and BCR-ABL


Genotyping of strains detected in cattle from a nationwide survey in Korea.

Authors:
Yo-Han Kim Doo Kim

J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.

Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, Korea.

A total of 123 strains detected in cattle from a nationwide survey in Korea were classified into the genomic groups I (0.8%), II (13.8%), III (11. Read More

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December 2018

Association between Dietary Glycemic Index and Excess Weight in Pregnant Women in the First Trimester of Pregnancy.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Group of Research in Nutrition and Chronic Diseases, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.

Objective:  To assess the association between dietary glycemic index (GI) and excess weight in pregnant women in the first trimester of pregnancy.

Methods:  A cross-sectional study in a sample of 217 pregnant women was conducted at the maternal-fetal outpatient clinic of the Hospital Geral de Fortaleza, Fortaleza, state of Ceará, Brazil, for routine ultrasound examinations in the period between 11 and 13 weeks + 6 days of gestation. Weight and height were measured and the gestational body mass index (BMI) was calculated. Read More

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December 2018

[Update of multimodal therapy in canine osteoarthritis].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):337-345. Epub 2018 Dec 12.

Canine osteoarthritis is a very common disease and the main cause for chronic pain in dogs. Progressive degeneration of joint cartilage, periarticular soft tissues and subchondral bone consecutively lead to osteophytes, inflammation and pain. It is an irreversible process. Read More

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October 2018

Intervertebral disc herniation in two coatis (Nasua nasua) and postoperative laminectomy membrane formation.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):330-336. Epub 2018 Dec 12.

Magnetic resonance imaging revealed spinal cord compression due to intervertebral disc herniation of Hansen type I and II in the thoracolumbar vertebral column in two middle-aged coatis () with chronic progressive paraparesis. Surgical treatment included hemilaminectomy and partial corpectomy in one and dorsal laminectomy in the other coati. Both coatis recovered well after surgery. Read More

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October 2018
3 Reads

[Cobalamin deficiency in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):309-314. Epub 2018 Dec 12.

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Read More

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October 2018
1 Read

Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn´s Disease.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Akershus University Hospital, Lørenskog, Norway.

Background: Crohns disease (CD) is a chronic inflammation in the gut that often progresses to fibrosis. Magnetic Resonance Enterography (MRE) is an important diagnostic tool in evaluating CD. We aimed to assess the prevalence of inflammation and stricturing disease in patients with long-term CD and investigate associations with clinical factors. Read More

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December 2018

Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

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December 2018
1 Read

Detecting moderate or complex congenital heart defects in adults from an electronic health records system.

J Am Med Inform Assoc 2018 Dec;25(12):1634-1642

Emory University School of Medicine, Atlanta, GA, USA.

Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.

Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More

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December 2018
3 Reads

Classification of chronic kidney disease 10 years on: what have we learnt in the Netherlands.

Fam Pract 2018 Dec;35(6):744-745

Department of Primary and Community Care, Radboud university medical center, Nijmegen, the Netherlands.

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December 2018

Educational level and risk of chronic kidney disease: longitudinal data from the PREVEND study.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association.

Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Read More

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December 2018

Hypertension in chronic kidney disease: Nephrology Dialysis Transplantation notable 2017 advances.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.

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December 2018

Severe vitamin D deficiency is a risk factor for renal hyperfiltration.

Am J Clin Nutr 2018 Dec;108(6):1342-1351

Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research.

Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population.

Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Read More

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December 2018

Health Burden, Instrumental and Emotional Support Adequacy, and Depressive Symptoms in Older Men With HIV.

Gerontologist 2018 Dec 12. Epub 2018 Dec 12.

Virginia Tech Center for Gerontology, Virginia Polytechnic Institute and State University, Blacksburg.

Background And Objectives: Older adults with HIV face greater health burden than HIV-uninfected counterparts. Little is known about resources that might mediate the influence of physiological health burden on psychological well-being. Informed by the stress process model, we assessed the influence of multifaceted health burden indicators on depressive symptoms and evaluated the mediating effects of social support adequacy. Read More

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December 2018

Assessment of drug interaction potential between the HCV direct-acting antiviral agents elbasvir/grazoprevir and the HIV integrase inhibitors raltegravir and dolutegravir.

J Antimicrob Chemother 2018 Dec 12. Epub 2018 Dec 12.

Merck & Co., Inc., Kenilworth, USA.

Background: Elbasvir/grazoprevir is a once-daily fixed-dose combination therapy for the treatment of chronic HCV infection, including HCV/HIV coinfection.

Objectives: To evaluate the pharmacokinetic interaction of elbasvir and grazoprevir with raltegravir or dolutegravir.

Methods: Three open-label trials in healthy adult participants were conducted. Read More

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December 2018
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Older HIV+ and HIV- Adults Provide Similar Definitions of Successful Aging: A Mixed-Methods Examination.

Gerontologist 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, University of California, San Diego.

Background And Objective: As HIV-infected (HIV+) individuals age, there is a need to understand successful aging (SA) from the patient perspective. This study compared SA definitions between HIV+ and HIV-uninfected (HIV-) older adults and then examined correlates of SA categories.

Research Design And Methods: Ninety-three HIV+ and 46 HIV- older (aged 50+) adults provided brief definitions of SA, which was examined using content analysis. Read More

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December 2018
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Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial.

J Gerontol A Biol Sci Med Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Background: Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (ω-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and ω-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized clinical trial. Read More

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December 2018
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Turning Pain into Gain: Evaluation of a Multidisciplinary Chronic Pain Management Program in Primary Care.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Queensland 4222, Australia and Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland 4222, Australia.

Objective: To measure the impact of the multidisciplinary Turning Pain Into Gain program in people experiencing chronic pain of any etiology.

Methods: A mixed-methods observational study of 252 participants was used to explore the impact of Turning Pain Into Gain on medication use; quality of life and functioning, as measured by the Pain Self-Efficacy Questionnaire; and self-reported hospitalizations between 2015 and 2016.

Results: Responses from 178 participants showed an increased alignment with Australian pain medication guidelines (e. Read More

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December 2018

Patterns and Perceptions of Self-Management for Osteoarthritis Pain in African American Older Adults.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

College of Nursing, The University of Iowa, Iowa City, Iowa, USA.

Objective: To explore and describe older African Americans' patterns and perceptions of managing chronic osteoarthritis pain.

Methods: A convergent parallel mixed-methods design incorporating cross-sectional surveys and individual, semistructured interviews.

Setting: One hundred ten African Americans (≥50 years of age) with clinical osteoarthritis (OA) or provider-diagnosed OA from communities in northern Louisiana were enrolled. Read More

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December 2018

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

Maternal Stress During Pregnancy Is Associated with Decreased Cortisol and Cortisone Levels in Neonatal Hair.

Horm Res Paediatr 2018 Dec 12:1-9. Epub 2018 Dec 12.

Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.

Background: Hair glucocorticoids (GCs) offer a retrospective view on chronic GC exposure. We assessed whether maternal pre- and postnatal stress was associated with neonatal and maternal hair GCs postpartum (pp).

Methods: On the first day pp 172 mother-infant pairs donated hair, of whom 67 had consulted a centre of expertise for psychiatric disorders during pregnancy. Read More

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December 2018

Measurements of Trunk Sway for Stance and Gait Tasks 2 Years after Vestibular Neurectomy.

Audiol Neurootol 2018 Dec 12;23(5):298-308. Epub 2018 Dec 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

The aim of this study was to investigate changes in balance control for stance and gait tasks in patients 2 years before and after vestibular neurectomy (VN) performed to alleviate intractable Meniere's disease. Amplitudes of trunk sway in roll and pitch directions were measured for stance and gait tasks in 19 patients using gyroscopes mounted at the lower-back. Measurements before VN and 2 years later were compared to those of healthy age-matched controls (HC). Read More

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December 2018

Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.

Cell Rep 2018 Dec;25(11):3194-3203.e4

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-like behavior in mice and resulted in a 5hmC reduction in prefrontal cortex (PFC). Read More

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December 2018

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.

Cell Rep 2018 Dec;25(11):3036-3046.e6

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA; Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address:

IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. We report here that inflammation induces the accumulation of CD11bGr1 myeloid-derived suppressor cells (MDSCs) that express high levels of IL-10 in colon tissue. Read More

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December 2018

Novel therapeutic approaches in primary hyperoxaluria.

Expert Opin Emerg Drugs 2018 Dec 12:1-9. Epub 2018 Dec 12.

a Division of Pediatric Nephrology , University Childrens Hospital, Universitatsklinikum Bonn , Bonn , Germany.

Introduction: Currently, three types of primary hyperoxaluria (PH I-III) are known, all based on different gene-mutations affecting the glyoxylate metabolism in the liver. Disease hallmark is an increased endogenous oxalate production and thus massively elevated urinary excretion of oxalate and other type-specific metabolites. Hyperoxaluria induces the formation of calcium-oxalate kidney stones and/or nephrocalcinosis. Read More

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December 2018

Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough.

Korean J Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.

Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response to ICS in patients with upper airway cough syndrome (UACS) or unexplained chronic cough (UCC). Sixty-eight patients with UACS and 33 patients with UCC (duration of cough ≥ 8 weeks) were treated with ICS: 250 µg of fluticasone propionate or 400 µg of budesonide twice a day at physician's discretion. Read More

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December 2018

A fistulating oropharyngeal lesion.

Ear Nose Throat J 2018 Dec;97(12):E15-E17

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85084, USA.

Post-transplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression. It can present throughout the head and neck, and tonsillar involvement is not limited to children. We report the case of a 67-year-old woman who developed odynophagia associated with putrid halitosis 4 months after she had undergone renal transplantation. Read More

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December 2018

Influence of polypharmacy on heart rate variability in older adults at the Hiroshima Atomic Bomb Survivors Recuperation Research Center, Japan.

PLoS One 2018 12;13(12):e0209081. Epub 2018 Dec 12.

Department of Food and Dietetics, Hiroshima Bunka Gakuen Two-Year College, 3-5-1 Nagatsukanishi, Asaminami-ku, Hiroshima, Japan.

Background: Many studies have identified the risk of polypharmacy, but physiological evidence and methods of evaluation in these studies were poor. The relationship between polypharmacy and heart rate variability in older adults remains unclear. We investigated the relationship between polypharmacy in older adults, including atomic bomb survivors, and heart rate variability. Read More

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December 2018

Patients who leave Emergency Department without being seen or during treatment in the Lazio Region (Central Italy): Determinants and short term outcomes.

PLoS One 2018 12;13(12):e0208914. Epub 2018 Dec 12.

Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.

Background And Aims: Patients who leave Emergency Department before physician's visit (LWBS) or during treatment (LDT) represent a useful indicator of the emergency care's quality. The profile of patients LWBS was described: they are generally males, young, with lower urgency triage allocation and longer waiting time. They have a greater risk of ED re-admission compared to discharged patients, but effect on hospitalization and mortality are more controversial. Read More

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December 2018

Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D.

PLoS One 2018 12;13(12):e0208806. Epub 2018 Dec 12.

Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Aims: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG. Read More

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December 2018

Cardiovascular disease risk in patients with hepatitis C infection: Results from two general population health surveys in Canada and the United States (2007-2017).

PLoS One 2018 12;13(12):e0208839. Epub 2018 Dec 12.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

The role of hepatitis C virus (HCV) infection in increasing the risk of cardiovascular disease (CVD) is controversial. The objective of the present study is to estimate the 10-year risk of CVD in HCV- positive subjects and describe their profile of cardiometabolic risk markers compared to HCV-negative subjects. We conducted a cross-sectional study to estimate 10-year CVD risk, calculated using the Framingham Risk Score (FRS), in participants from the Canadian Health Measures Survey (CHMS; 2007-2015, n = 10,115) and the US-National Health and Nutrition Examination Survey (NHANES; 2007-2016, n = 16,668). Read More

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December 2018
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Correlation and prognostic accuracy between noninvasive liver fibrosismarkers and portal pressure in cirrhosis: Role of ALBI score.

PLoS One 2018 12;13(12):e0208903. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: The role of noninvasive liver fibrosis markers which were developed to evaluate the severity of chronic liver disease remains unclear in cirrhosis.

Aims: To evaluate the correlation between noninvasive markers and hemodynamic parameters and their prognostic performance in cirrhotic patients.

Methods: A total of 242 cirrhotic patients undergoing hemodynamic study were analyzed. Read More

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December 2018

Education and work participation among adults with congenital unilateral upper limb deficiency in Norway: A cross-sectional study.

PLoS One 2018 12;13(12):e0207846. Epub 2018 Dec 12.

Innlandet Hospital Trust, Department of Physical Medicine and Rehabilitation, Ottestad, Norway.

Objectives: To describe level of education and work participation among adults with congenital unilateral upper limb deficiency (CUULD) in Norway and to explore associations between work participation and demographic and clinical factors.

Methods: Cross-sectional study. In 2012, a postal questionnaire was sent to 186 persons with congenital limb deficiency (CLD), age ≥ 20 years, registered at the TRS National Resource Center for Rare Disorders. Read More

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December 2018

The National Institutes of Health measure of Healing Experience of All Life Stressors (NIH-HEALS): Factor analysis and validation.

PLoS One 2018 12;13(12):e0207820. Epub 2018 Dec 12.

Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America.

Two hundred patients with severe and/or life-threatening disease were recruited form the NIH Clinical Center and participated in the validation of the NIH-HEALS, which included exploratory factor analysis, principal component analysis, reliability, convergent validity, and divergent validity analyses. Item-reducing principal components analysis and internal consistency and split-half reliability demonstrated excellent internal consistency and split-half reliability (Cronbach's alpha = 0.89, split-half reliability = 0. Read More

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December 2018

Chronic lifestyle diseases display seasonal sensitive comorbid trend in human population evidence from Google Trends.

PLoS One 2018 12;13(12):e0207359. Epub 2018 Dec 12.

Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Timarpur, Delhi, India.

Seasonal and human physiological changes are important factors in the development of many diseases. But, the study of genuine seasonal impact on these diseases is difficult to measure due to many other environment and lifestyle factors which directly affect these diseases. However, several clinical studies have been conducted in different parts of the world, and it has clearly indicated that certain groups of population are highly subjected to seasonal changes, and their maladaptation can possibly lead to several disorders/diseases. Read More

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December 2018

[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):280-284

Facultad de Medicina Humana, Universidad Nacional San Luis Gonzaga. Ica, Perú; Sociedad Científica de Estudiantes de Medicina de Ica (SOCEMI). Ica, Perú.

Gaucher disease is an autosomal recessive lysosomal storage disorder characterized by deficiency of beta-glucosidase that would lead to the accumulation of glucosylceramide mainly in cells of the mononuclear phagocytic system causing systemic effectations. We present a patient of twenty years who is suffering from chronic pain in the left hypochondrium with episodes of bleeding for 3 years and sensation of thermal rise, physical examination revealed jaundice and massive splenomegaly, without neurological involvement. Severe osteoporosis, pancytopenia, and the presence of portal vein thrombosis with cavernomatous transformation complicated by portal biliopathy simulating a klatskin tumor, marrow and enzymatic studies were compatible with Gaucher disease, were shown as unexpected findings. Read More

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December 2018

High Prevalence of Spinal Magnetic Resonance Imaging Findings in Asymptomatic Young Adults (18-22 Yrs) Candidate to Air Force Flight.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Headquarters Joint Force Command (HQ JFC) of the North Atlantic Treaty Organization (NATO), Lago Patria, Giugliano in Campania (NA), Italy.

Study Design: Cross-sectional, retrospective, magnetic resonance (MR) imaging study, performed during cadets' selection procedures of the Italian Air Force Academy.

Objective: To assess the prevalence of spinal MR imaging findings in asymptomatic young adults (18-22 yrs) candidate to Air Force Flight.

Summary Of Background Data: Spinal MR imaging findings are frequently detected in asymptomatic subjects. Read More

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December 2018

Characterization of Brain Signatures to Add Precision to Self-Management Health Information Interventions.

Nurs Res 2018 Dec 12. Epub 2018 Dec 12.

Edward J. and Louise Mellen Professor of Nursing, Case Western Reserve University, Cleveland, OH Marvin E. and Ruth Durr Denekas Professor of Nursing, Case Western Reserve University, Cleveland, OH Associate Professor, Case Western Reserve University, Cleveland, OH PhD Student, Case Western Reserve University, Cleveland, OH Professor, Kent State University, Kent, OH Assistant Professor, Case Western Reserve University, Cleveland, OH Assistant Professor, Chief Diversity Officer, The Ohio State University, Columbus, OH Associate Professor, Case Western Reserve University, Cleveland, OH Associate Professor, Case Western Reserve University, Cleveland, OH.

Background: Although many of the proposed mediating processes of self-management interventions are operationally defined as cognitive processes (e.g., acquiring and using information, self-efficacy, motivation, decision-making), little is known about their underlying brain mechanisms. Read More

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December 2018

Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis.

Otol Neurotol 2019 Jan;40(1):e32-e39

Department of Otorhinolaryngology.

Objectives: Patients with otosclerosis more often complain about postoperative taste disturbance than patients with chronic otitis media, which seems paradoxical. We aim to investigate if and potentially why this seems to be the case, since the chorda tympani nerve (CTN) is thought to be severely traumatized less frequently during surgery in the former than in the latter.

Study Design: Prospective cohort study. Read More

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January 2019

Comparison of Candesartan and Angiotensin-(1-7) Combination and Mito Tempo Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (Mren2)27 Rats.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.

Hypertensive transgenic (mRen2)27 rats exhibit impaired baroreflex sensitivity (BRS) for control of heart rate (HR). Intracerebroventricular (ICV) infusion of Ang-(1-7) improves indices of vagal BRS independent of lowering mean arterial pressure (MAP), while AT1 receptor blockade normalizes MAP and indices of sympathetic tone without correcting the vagal BRS. Scavenging cellular reactive oxygen species (ROS) with tempol in brain fails to correct either hypertension or sympathovagal balance in these animals, despite reports that mitochondrial ROS contributes to Ang II-infusion hypertension. Read More

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December 2018

Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

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January 2019

Use of Well-Being in Identification of Members with Future Health Risk Factors and Future Diagnosed Chronic Disease.

J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Research and Advanced Data Science, Sharecare, Inc, 701 Cool Springs Boulevard, Franklin, TN 37067 (Hamar, Jones, Rickles); Concert Genetics, Inc., 810 Crescent Center Drive, Suite 280, Franklin, TN 37067 (Coberley); Tivity Health, 701 Cool Springs Boulevard, Franklin, TN 37067 (Rula).

Objective: To evaluate if well-being is associated with the development of future health risks or incidence of new chronic disease.

Methods: A retrospective cohort study was employed using longitudinal well-being assessment survey data from participants of a Fortune 500 U.S. Read More

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December 2018

Voluntary wheel running reveals sex specific nociceptive factors in murine experimental autoimmune encephalomyelitis.

Pain 2018 Dec 11. Epub 2018 Dec 11.

Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1.

Multiple Sclerosis (MS) is an inflammatory, neurodegenerative autoimmune disease associated with sensory and motor dysfunction. Although estimates vary, ∼50% of patients with MS experience pain during their disease. The mechanisms underlying the development of pain are not fully understood and no effective treatment for MS related pain is available. Read More

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December 2018

Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics.

Pain 2018 Oct 17. Epub 2018 Oct 17.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Although self-report pain ratings are the gold standard in clinical pain assessment, they are inherently subjective in nature and significantly influenced by multidimensional contextual variables. Although objective biomarkers for pain could substantially aid pain diagnosis and development of novel therapies, reliable markers for clinical pain have been elusive. In this study, individualized physical maneuvers were used to exacerbate clinical pain in patients with chronic low back pain (N = 53), thereby experimentally producing lower and higher pain states. Read More

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October 2018
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The effect of task-oriented electromyography-triggered electrical stimulation of the paretic wrist extensors on upper limb motor function early after stroke: a pilot randomized controlled trial.

Int J Rehabil Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey.

The combined effect of task-oriented motor training and electromyography (EMG)-triggered electrical stimulation (ES) has been examined in chronic stroke, but there are no published reports in patients with early stroke. Therefore, the purpose of this study was to determine the short-term and long-term effects of task-oriented EMG-triggered ES on upper limb motor function in acute/subacute stroke. Twenty-seven patients with stroke within the first 3 months after stroke onset were randomly allocated to an experimental group and a control group. Read More

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December 2018
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Clavicle Fracture Malunion Treated with an Osteotomy Guided by a Three-Dimensional-Printed Model: A Case Report.

JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, University of California, San Francisco Medical Center, San Francisco, California.

Case: This case report describes the management of a chronic and symptomatic clavicle malunion with use of a 3-dimensional (3D)-printed model during the preoperative surgical planning.

Conclusion: The use of 3D printing has many applications in the medical field. Constant improvement in the quality of 3D printing has contributed to its increased use in a variety of surgeries. Read More

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December 2018

Postactivated B cells in systemic lupus erythematosus: update on translational aspects and therapeutic considerations.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine/Rheumatology and Clinical Immunology.

Purpose Of Review: This review summarizes recent insights and current understanding of the role of postactivated B cells in SLE and related pathogenic and potential therapeutic implications.

Recent Finding: B cells are considered key players in SLE and experience from various B-cell-targeted therapies underlines their clinical relevance. In the last years, new insights have been obtained on B-cell abnormality within the complex pathophysiology of SLE. Read More

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December 2018

Complementary and integrative medicine in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Purpose Of Review: Complementary and integrative medicine (CIM) use is widely prevalent in kidney transplant recipients but studies of efficacy or potential harm are sparse. This review examines prevalence of use of CIM and discusses potential beneficial and harmful aspects of CIM in renal transplant recipients.

Recent Findings: The prevalence of CIM use in kidney transplant patients varies from 12 to 45%. Read More

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December 2018

Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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December 2018
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