Arch Pathol Lab Med 2021 Jun 4. Epub 2021 Jun 4.
From the Department of Pathology (Irshaid, Garritano, Patsenker, Kluger, Katz, Xu), Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut.
Context.—: Large-cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relatively straightforward to diagnose in lymph nodes, a marrow biopsy is often obtained first given its ease of procedure, low cost, and low morbidity. Read More