136,101 results match your criteria Chronic Laryngitis Infectious or Allergic


Tofacitinib suppresses mast cell degranulation and attenuates experimental allergic conjunctivitis.

Int Immunopharmacol 2020 Jun 29;86:106737. Epub 2020 Jun 29.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Allergic conjunctivitis (AC), a common eye inflammation that affects patients' health and quality of life, is still a therapeutic challenge for ophthalmologists. Tofacitinib, a new Janus kinase (JAK) inhibitor, has been successfully used in the treatment of several disorders. Nonetheless, its effect in AC and the potential anti-allergic mechanisms are still unclear. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106737DOI Listing

Shared Decision-making in Allergic Rhinitis: An Approach to the Patient.

Authors:
Gary C Steven

Ann Allergy Asthma Immunol 2020 Jun 29. Epub 2020 Jun 29.

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http://dx.doi.org/10.1016/j.anai.2020.06.032DOI Listing

Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury.

Ocul Surf 2020 Jun 29. Epub 2020 Jun 29.

Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA. Electronic address:

Purpose: Neutrophils play a critical role in defending against threats such as microbial infection, yet their activation during innate immune response incites collateral damage to healthy tissues. We have previously shown that corneal injury induces mast cells to express the neutrophil chemoattractant CXCL2. Here we delineate the mechanism of injury-induced, non-IgE-mediated mast cell activation at the ocular surface. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.06.006DOI Listing

House dust microbiota in relation to adult asthma and atopy in a U.S. farming population.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Dept. of Health and Human Services (DHHS), Research Triangle Park (RTP), North Carolina (NC), USA. Electronic address:

Background: Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear.

Objective: To examine associations of house dust microbiota with adult asthma, atopy, and hay fever.

Methods: Vacuumed bedroom dust samples from the homes of 879 participants (average age 62) in the Agricultural Lung Health Study, a case-control study of asthma nested within a farming cohort, were subjected to 16S rRNA amplicon sequencing to characterize bacterial communities. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.013DOI Listing

Can moderate-intensity aerobic exercise ameliorateatopic dermatitis?

Exp Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Allergy Immunology Center, Korea University, Seoul, Korea.

It has been shown that aerobic exercise improves atopic dermatitis (AD), although the mechanism is not clear. Here, we propose a hypothesis that moderate-intensity aerobic exercise improvesAD ina mouse model through modulating allergic inflammation.The DNCB-treated mouse model for eczemawere divided into 3 groups: 1) not subjected to aerobic exercise, 2) subjected to continuous aerobic exercise and, 3) subjected to accumulated aerobic exercise. Read More

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http://dx.doi.org/10.1111/exd.14138DOI Listing

Molecular allergen sensitization of Aspergillus fumigatus between allergic bronchopulmonary aspergillosis and A fumigatus-sensitized asthma in Guangzhou, Southern China.

J Clin Lab Anal 2020 Jul 2:e23448. Epub 2020 Jul 2.

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Few studies have assessed the sensitization of mycotic allergens and Aspergillus fumigatus molecular allergens. This study aimed to investigate the relationships of A fumigatus components and mycotic allergens in allergic bronchopulmonary aspergillosis (ABPA) patients and A fumigatus (Af)-sensitized asthma patients.

Methods: Serum sIgE levels of Penicillium chrysogenum, Cladosporium herbarum, Mucor racemosus, Candida albicans, Alternaria alternata, Helminthosporium halodes, and A fumigatus allergen components (Asp f 1, Asp f 2, Asp f 3, Asp f 4, and Asp f 6) were measured via the ImmunoCAP assay in 18 ABPA and 54 Af-sensitized asthma patients in Guangzhou city, China. Read More

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http://dx.doi.org/10.1002/jcla.23448DOI Listing

Allergic contact dermatitis caused by Lavandula angustifolia and cross-reaction with Citrus bergamia essential oils in an aromatherapist.

Int J Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology. Hospital, Universitario San Cecilio, Granada, Spain.

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http://dx.doi.org/10.1111/ijd.15027DOI Listing

[Scombroid food poisoning among hospital personnel].

Ned Tijdschr Geneeskd 2020 May 20;164. Epub 2020 May 20.

Diakonessenhuis, Utrecht.Afd. Interne Geneeskunde.

Background: Scombroid food poisoning is caused by eating fish with a high concentration of histamine. Histamine is converted from histidine in fish of the Scombroidea family if it is not stored at a sufficiently low temperature. The clinical picture resembles an allergic reaction. Read More

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Period2 gene regulates diurnal changes of nasal symptoms in an allergic rhinitis mouse model.

Int Forum Allergy Rhinol 2020 Jul 1. Epub 2020 Jul 1.

Shanxi Medical University, Taiyuan, China.

Background: Allergic rhinitis (AR) symptoms exhibit prominent 24-hour variations associated with the biological clock. Although endogenous glucocorticoids synchronize circadian oscillator in the nasal mucosa, the precise mechanism of AR remains unclear. Therefore, using a mouse model, we investigated the association between circadian-clock genes and AR symptoms at various time-points. Read More

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http://dx.doi.org/10.1002/alr.22607DOI Listing

Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety.

Drug Saf 2020 Jul 1. Epub 2020 Jul 1.

Perron Institute for Neurological and Translational Sciences, First Floor, RR Block, QEII Medical Centre, Nedlands, WA, Australia.

Cationic arginine-rich peptides represent a novel class of peptides being developed as neuroprotective agents for stroke and other acute and chronic neurological disorders. As a group, cationic arginine-rich peptides have a diverse range of other biological properties including the ability to traverse cell membranes, modulate immune responses, antagonise ion channel receptor function, as well as possessing cardioprotective, anti-nociceptive, anti-microbial and anti-cancer properties. A sound understanding of their safety profile is essential for the design of future clinical trials and for ensuring translational success with these compounds. Read More

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http://dx.doi.org/10.1007/s40264-020-00962-zDOI Listing

Breast Cancer Survivorship, Quality of Life, and Late Toxicities.

Front Oncol 2020 16;10:864. Epub 2020 Jun 16.

Department of Translational Medicine, University of Eastern Piedmont, DIMET, Novara, Italy.

Breast cancer is the most frequent cancer in women: in 2018, almost two million cases have been diagnosed all over the world and it represents the principal cause of death from a neoplastic disease in women. In the past years, breast cancer prognosis has significantly improved over time: currently 5-year survival rates are in the range of 90%, and 10-year survival is about 80%. This improvement has been mostly observed in western countries, due to high coverage and compliance with screening programs, leading to early diagnosis, i. Read More

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http://dx.doi.org/10.3389/fonc.2020.00864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308500PMC

Successful treatment of eosinophilic chronic rhinosinusitis and eosinophilic otitis media using the anti-IL-5 receptor monoclonal antibody benralizumab: A case report.

Respir Med Case Rep 2020 17;30:101135. Epub 2020 Jun 17.

Department of Otolaryngology, Tenri Hospital, Nara, Japan.

Eosinophilic chronic rhinosinusitis (ECRS) is characterized by the presence of nasal polyps, dominant ethmoid shadows in computed tomography (CT) scans, and elevated levels of eosinophil infiltration into the nasal polyps and peripheral blood. ECRS is often accompanied by severe asthma. The recent development of monoclonal antibody-based biologics, including benralizumab, has offered new therapeutic approaches for the treatment of asthma and allergic diseases. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322358PMC

Expedited Desensitization to Canakinumab.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720937694. Epub 2020 Jun 22.

Allergy Immunology Associates, Inc., Mayfield Heights, Ohio.

Introduction: Interleukin-1 (IL-1) antagonists have been successful in the management of monogenic auto-inflammatory diseases, notably classic hereditary fever syndromes, such as Familial Mediterranean Fever (FMF). Anakinra (Kineret®), a human recombinant IL-1 receptor antagonist (IL-1Ra), has been clinically effective in the management of persistent auto-inflammation, such as FMF. Few studies report anaphylaxis in response to anakinra, which were resolved with an anakinra desensitization or the anti-IL-1β monoclonal antibody canakinumab (ILARIS®). Read More

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http://dx.doi.org/10.1177/2152656720937694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309336PMC

Skin prick reactivity among asthmatics in East Africa.

World Allergy Organ J 2020 Jun 23;13(6):100130. Epub 2020 Jun 23.

Makerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: The burden of asthma in Africa is high, and yet the disease is not universally prioritised. Data on allergic asthma and its impact on asthma morbidity are limited in Africa. Our aim was to describe the distribution of skin prick positivity among asthmatics in Eastern Africa. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322185PMC

Nasal IgE in subjects with allergic and non-allergic rhinitis.

World Allergy Organ J 2020 Jun 23;13(6):100129. Epub 2020 Jun 23.

Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.

Purpose: The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students.

Methods: 131 students (age 25. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322186PMC

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study.

World Allergy Organ J 2020 Jun 23;13(6):100127. Epub 2020 Jun 23.

Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: Some studies have shown associations of maternal age at delivery with asthma and food allergy in offspring. However, the relationship between maternal age at delivery and allergic rhinitis is largely unclear. This study aimed to investigate the association between maternal age at delivery and allergic rhinitis in a population sample of Asian children, and to explore potential effect modifiers. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322179PMC

Summer Buzz: All You Need to Know about Insect Sting Allergies.

Pediatr Rev 2020 Jul;41(7):348-356

UT Health San Antonio, San Antonio, TX.

Insect stings can generate a range of immune and clinical reactions. Most reactions are local and self-limiting. Allergic reactions to insect stings can occur at all ages, with or without previous stings. Read More

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http://dx.doi.org/10.1542/pir.2018-0358DOI Listing

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD.

Respir Res 2020 Jul 1;21(1):166. Epub 2020 Jul 1.

Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

Background: Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely studied but few studies have examined the prognostic value of blood neutrophil counts (BNC). Read More

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http://dx.doi.org/10.1186/s12931-020-01436-7DOI Listing

Environmental and Endogenous Acids Can Trigger Allergic-Type Airway Reactions.

Int J Environ Res Public Health 2020 Jun 29;17(13). Epub 2020 Jun 29.

Elsa Nervo, Società Chimica Italiana, 00198 Rome, Italy.

Inflammatory allergic and nonallergic respiratory disorders are spreading worldwide and often coexist. The root cause is not clear. This review demonstrates that, from a biochemical point of view, it is ascribable to protons (H) released into cells by exogenous and endogenous acids. Read More

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http://dx.doi.org/10.3390/ijerph17134688DOI Listing

Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Department of Medicinal Biosciences, Research Institute for Biomedical & Health Science, College of Biomedical and Health Science, Konkuk University, 268 Chungwon-daero Chungju-si 27478, Korea.

Apigenin (4',5,7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin analyzed its effect on histamine release in the 1950s. Since then, anti-mutation and antitumor properties of apigenin have been widely reported. Read More

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http://dx.doi.org/10.3390/ijms21134620DOI Listing

Role of myeloid cells in the regulation of ILC2-mediated allergic inflammation.

Immunology 2020 Jul 1. Epub 2020 Jul 1.

Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang, China.

Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like Th2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation and eliminating helminth infections. The past few years have contributed to our better understanding of the interactions between ILC2s and other cells of immune system via soluble factors or in a cell-cell contact manner. Read More

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http://dx.doi.org/10.1111/imm.13232DOI Listing

Maternal microbiome regulation prevents early allergic airway diseases in mouse offspring.

Pediatr Allergy Immunol 2020 Jul 1. Epub 2020 Jul 1.

Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.

Background: Asthma is a serious global health problem, severely affecting the lives of sufferers and their families. An exceptionally hygienic home and reduced microbial exposure can aggravate the incidence of childhood asthma.

Methods: Specific-pathogen-free BALB/c mice were pretreated with bacterial lysate (BL; 1 mg/kg) as a high microbial load maternal mice model, then the offspring mice were established as an allergic airway disease (AAD) model. Read More

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http://dx.doi.org/10.1111/pai.13315DOI Listing

Potential role of diacylglycerol kinases in immune-mediated diseases.

Clin Sci (Lond) 2020 Jul;134(13):1637-1658

Department of Translational Medicine, University of Eastern Piedmont, via Solaroli 17, 28100 Novara, Italy.

The mechanism promoting exacerbated immune responses in allergy and autoimmunity as well as those blunting the immune control of cancer cells are of primary interest in medicine. Diacylglycerol kinases (DGKs) are key modulators of signal transduction, which blunt diacylglycerol (DAG) signals and produce phosphatidic acid (PA). By modulating lipid second messengers, DGK modulate the activity of downstream signaling proteins, vesicle trafficking and membrane shape. Read More

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http://dx.doi.org/10.1042/CS20200389DOI Listing

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production.

Clin Sci (Lond) 2020 Jul 1. Epub 2020 Jul 1.

Central South University, Changsha, China.

Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is downregulated in the airway epithelium of asthma patients.  Although a few studies hint towards the role of ITGB4 in asthmatic inflammation pathogenesis, their specific resultant effects remain unexplored. Read More

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http://dx.doi.org/10.1042/CS20191188DOI Listing

Updates on Vaccine Safety and Post-Licensure Surveillance for Adverse Events Following Immunization in South Korea, 2005-2017.

Yonsei Med J 2020 Jul;61(7):623-630

School of Pharmacy, Sungkyunkwan University, Suwon, Korea.

Purpose: Vaccine hesitancy is among the top ten threats to global health, and access to precise data on adverse events following immunization (AEFIs) is imperative to alleviate public concerns surrounding vaccines. This study aimed to present the overall trends of AEFIs reported in South Korea.

Materials And Methods: We evaluated the trends of AEFIs using the Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System database between January 2005 and December 2017. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.7.623DOI Listing

Construction workers' skin disorders in the Finnish Register of Occupational Diseases in 2005-2016.

Contact Dermatitis 2020 Jul 1. Epub 2020 Jul 1.

Finnish Institute of Occupational Health (FIOH), Occupational health unit, Helsinki, Finland.

Background: Construction workers are a known risk group for occupational skin disease (OSD).

Aims: To study diagnoses and causes of construction workers' OSD in the Finnish Register of Occupational Diseases (FROD) in 2005-2016.

Methods: We searched the FROD for dermatological cases (i) in construction-related occupations defined by ISCO-08 and (ii) in the industrial branch of construction defined by European industry standard classification system (NACE rev. Read More

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http://dx.doi.org/10.1111/cod.13648DOI Listing

The Versatile UV Absorber Drometrizole: Expanding from the realm of Cosmetics to Feminine Sanitary Products.

Contact Dermatitis 2020 Jul 1. Epub 2020 Jul 1.

Park Nicollet Contact Dermatitis Clinic, Minneapolis, Minnesota.

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http://dx.doi.org/10.1111/cod.13651DOI Listing

Contact dermatitis caused by glucose sensors - 15 adult patients tested with a medical device patch test series.

Contact Dermatitis 2020 Jul 1. Epub 2020 Jul 1.

Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

Background: Several cases of allergic contact dermatitis (ACD) to the glucose sensor FreeStyle Libre have been reported. Isobornyl acrylate (IBOA) and N,N-dimethylacrylamide (DMAA) are known culprit allergens.

Objectives: To evaluate patients with suspected ACD to FreeStyle Libre in a standardized manner, present causative allergens and assess patient-reported implications. Read More

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http://dx.doi.org/10.1111/cod.13649DOI Listing

Patch testing and diagnosis when suspecting allergic contact dermatitis from medical devices.

Contact Dermatitis 2020 Jul 1. Epub 2020 Jul 1.

Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1111/cod.13650DOI Listing

Symptoms of titanium and nickel allergic sensitization in orthodontic treatment.

Prog Orthod 2020 Jul 1;21(1):17. Epub 2020 Jul 1.

Department of Orthodontics, University of Rijeka, Faculty of Dental Medicine, Kresimirova 40, 51000, Rijeka, Croatia.

Aim: The study aimed to evaluate to which extent self-reported symptomatology, age, and sex are predictors of titanium and nickel allergic sensitization in patients in treatment with fixed orthodontic appliances.

Methods: The study analyzed 228 subjects aged 11-45 years (median 18, interquartile range 16-22); 68% of them were females, and 52% were adolescents. The allergic sensitization testing included epicutaneous patch test to titanium, titanium dioxide, titanium oxalate, titanium nitride, and nickel sulfate. Read More

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http://dx.doi.org/10.1186/s40510-020-00318-4DOI Listing

Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis.

Clin Transl Allergy 2020 26;10:25. Epub 2020 Jun 26.

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Via Alessandro Manzoni 56, 20089 Rozzano, MI Italy.

Background: A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis with nasal polyps (CRSwNP), the presence of which may adversely affect asthma treatment outcomes. The biologic agent omalizumab is effective as add-on therapy in patients with severe allergic asthma. The aim of this post hoc analysis of the PROXIMA study was to compare the efficacy of omalizumab between patients with severe allergic asthma, with and without comorbid CRSwNP. Read More

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http://dx.doi.org/10.1186/s13601-020-00330-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318524PMC

Type I allergic reaction to rituximab upon first lifetime exposure: a case report.

Allergy Asthma Clin Immunol 2020 26;16:56. Epub 2020 Jun 26.

Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC Canada.

Background: While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Case Presentation: We describe a case of a 58-year-old female patient who received rituximab for the first time for treatment of rheumatoid arthritis. She developed symptoms immediately after infusion, however presented 11 days after drug exposure with cyclical anaphylaxis-like reaction requiring multiple doses of epinephrine. Read More

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http://dx.doi.org/10.1186/s13223-020-00448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318363PMC

Treatment Options for Cow's Milk Protein Allergy: A Modeling Analysis.

Clinicoecon Outcomes Res 2020 17;12:307-315. Epub 2020 Jun 17.

Cukurova University Medical School, Allergy and Immunology Department, Adana, Turkey.

Purpose: Cow's milk protein allergy (CMPA) is one of the most common food allergies in early childhood. We aimed to evaluate clinical and economic outcomes of the amino-acid formula (AAF) and extensively hydrolyzed formula (eHF) based treatment of CMPA by using data available from Turkey and otherwise from literature.

Materials And Methods: A theoretical model was developed to evaluate AAF and eHF for CMPA treatment in terms of the number of children tolerating formula or experiencing an allergic reaction or withdrawing formula due to taste or other palatability features and CMPA related direct medical costs from the payer perspective. Read More

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http://dx.doi.org/10.2147/CEOR.S242021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306455PMC

[Diagnosis and treatment of acute tonsillopharyngitis. Consensus document update].

An Pediatr (Barc) 2020 Jun 27. Epub 2020 Jun 27.

Sociedad Española de Pediatría Extrahospitalaria y Atención Primaria (SEPEAP).

An update of the Spanish consensus document on the diagnosis and treatment of acute tonsillopharyngitis is presented. Clinical scores should not be used to prescribe antibiotics, unless microbiological tests are not available or there is a child at risk of rheumatic fever. There is no score better than those set out in the previous consensus. Read More

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http://dx.doi.org/10.1016/j.anpedi.2020.05.004DOI Listing

Global lockdown, pollution, and respiratory allergic diseases: Are we in or are we out?

J Allergy Clin Immunol 2020 Jun 22. Epub 2020 Jun 22.

Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla, Florence, Italy.

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http://dx.doi.org/10.1016/j.jaci.2020.05.047DOI Listing

Successful treatment of coronavirus disease 2019 in a patient with asthma.

Allergy Asthma Proc 2020 Jul;41(4):296-300

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases the risk for severe COVID-19 infection. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200044DOI Listing

Long-term efficacy of injected allergen immunotherapy for treatment of grass pollen allergy in elderly patients with allergic rhinitis.

Allergy Asthma Proc 2020 Jul;41(4):271-277

Humanitas Research Hospital, Milano, Italy.

The effect of prolonged allergen immunotherapy is still insufficiently known, especially in elderly patients. The effect after a 3-year course of injected allergen-specific immunotherapy (AIT) for grass pollen allergy in elderly patients with allergic rhinitis was observed. Thirty-eight elderly patients (mean ± standard deviation, 66. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200035DOI Listing

Treatment with azelastine hydrochloride and fluticasone propionate in a single delivery device of young children and adolescents with allergic rhinitis.

Allergy Asthma Proc 2020 Jul;41(4):232-239

Clinic of Occupational Diseases, University Hospital Sv. Ivan Rilski, Sofia, Bulgaria.

Allergic rhinitis (AR) is the most common chronic noncommunicable disease worldwide that affects any age during the human life span but raises particular concerns among the parents and caregivers of the children who are affected. H-receptor antagonists and corticosteroids provide the most effective way of bringing the condition under control. Intranasal application of these medications has the advantage of a faster onset of action and avoids systemic unwanted adverse effects. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200034DOI Listing

A case of Asthma with Behcet's disease: successful treatment with Omalizumab and its effects on recurrent aphthous lesions.

Immunopharmacol Immunotoxicol 2020 Jul 1:1-12. Epub 2020 Jul 1.

Department of Infectious Diseases and Clinical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Monoclonal antibody therapies have revolutionized the treatment of autoinflammatory-immune/genetic disease including spondylarthritis, asthma and rheumatoid arthritis. Behcet's disease (BD) is a multi-systemic vasculitis, which is generally recurrent aphthous lesions (RAL) as well as ocular and skin lesions. Today, the immunohistopathogenesis of BD is mostly unknown. Read More

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http://dx.doi.org/10.1080/08923973.2020.1789656DOI Listing

[Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].

Authors:
J B Sun Z L Li

Zhonghua Er Ke Za Zhi 2020 Jul;58(7):559-563

Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.

To investigate the relationship between gene polymorphism of rs2228055 locus in the exon region of interleukin-10 receptor A (IL-10RA) and susceptibility to food allergy in children. This was a case-control study. The food allergy group had 150 children who were diagnosed with food allergy in the Pediatric Food Allergy Clinic of Peking University Third Hospital from August 1, 2017 to November 30, 2018. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200425-00433DOI Listing

Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Ovalbumin-Challenged Asthma.

Antioxidants (Basel) 2020 Jun 27;9(7). Epub 2020 Jun 27.

Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Korea.

is widespread in northeast Asia and used for treatment of improvement of blood circulation and anti-inflammation. In this study, we investigated anti-inflammatory and anti-oxidant effects of the methanolic extract of leaves (LOL) in an ovalbumin (OVA)-challenged allergic asthma model and tumor necrosis factor (TNF)-α-stimulated NCI-H292 cell. Female BALB/c mice were sensitized with OVA by intraperitoneal injection on days 0 and 14, and airway-challenged with OVA from days 21 to 23. Read More

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http://dx.doi.org/10.3390/antiox9070563DOI Listing

COVID-19: Unmasking Telemedicine.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Division of Pulmonary, Allergy and Critical Care, Department of Medicine, NorthShore University HealthSystem, Evanston, IL. Electronic address:

Telemedicine adoption has rapidly accelerated since the onset of the COVID-19 pandemic. Telemedicine provides increased access to medical care and helps to mitigate risk by conserving personal protective equipment and providing for social/physical distancing in order to continue to treat patients with a variety of allergic and immunologic conditions. During this time, many allergy and immunology clinicians have needed to adopt telemedicine expeditiously in their practices while studying the complex and variable issues surrounding its regulation and reimbursement. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.06.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320693PMC

Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions.

J Allergy Clin Immunol 2020 Jun 27. Epub 2020 Jun 27.

Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig Holstein, Lübeck, Germany; Airway Research Center North (ARCN), University of Lübeck, German Center for Lung Research (DZL), Lübeck, Germany. Electronic address:

Murine blood IgG1, but not IgG2a, sialylation levels attenuate IgG-mediated and IgG-controlled IgE-mediated allergic reactions by enhancing the expression of the IgG inhibitory Fcγ receptor IIB on immune cells, accordingly, human blood IgG sialylation levels correlate with FcγRIIB expression. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.05.056DOI Listing

Age-of-onset information helps identify 76 genetic variants associated with allergic disease.

PLoS Genet 2020 Jun 30;16(6):e1008725. Epub 2020 Jun 30.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergology, and University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008725DOI Listing

Pharmacotherapeutic management of atopic keratoconjunctivitis.

Expert Opin Pharmacother 2020 Jun 30:1-9. Epub 2020 Jun 30.

Department of Ophthalmology, Queens Hospital, Barking Havering and Redbridge University Hospitals NHS Trust , Romford, UK.

Introduction: Atopic keratoconjunctivitis (AKC) is a form of allergic eye disease that can have sight threating implications. Prevalence is underestimated due to scarce published data and treatment is expanding as a result of limitations of current strategies. This article aims to provide an up-to-date overview of AKC and summarize current and upcoming management. Read More

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http://dx.doi.org/10.1080/14656566.2020.1786534DOI Listing

Allergic contact dermatitis to immobilization mask used in radiation therapy.

Pediatr Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Thermoplastic masks made of polyester resin are used to immobilize patients receiving radiation therapy. We describe a case of allergic contact dermatitis (ACD) to a thermoplastic mask worn by a child receiving proton beam therapy for treatment of medulloblastoma. ACD to a thermoplastic mask in an adult was first reported in 2018. Read More

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http://dx.doi.org/10.1111/pde.14260DOI Listing

Strategic Outlook toward 2030: Japan's research for allergy and immunology - Secondary publication.

Allergol Int 2020 Jun 26. Epub 2020 Jun 26.

Division of Molecular Genetics, The Jikei University School of Medicine, Research Center for Medical Science, Tokyo, Japan. Electronic address:

Strategic Outlook toward 2030: Japan's Research for Allergy and Immunology (Strategy 2030) is the national research strategy based on Japan's Basic Law on Measures Against Allergic Diseases, a first of its kind worldwide. This strategy was established by a multi-disciplinary committee consisting of administrators of the Ministry of Health, Labour and Welfare of Japan, young and senior experts from various research societies and associations, and representatives of patient and public groups. Whereas the issues of transition, integration, and international collaboration have yet to be solved in this research realm in Japan, identification of unmet needs, digitization of information and transparent procedures, and strategic planning for complex problems (a process dubbed MIERUKA by the Toyota Way) are crucial to share and tackle the same vision and goals. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.006DOI Listing

Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis.

Allergol Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.

Background: Condition of asthma in patients with asthma and concomitant seasonal allergic rhinitis (SAR) deteriorates during the Japanese cedar pollen (JCP) season. However, the underlying mechanisms remain unclear.

Methods: We analyzed seasonal variations in eicosanoid levels in the airways of patients with asthma and concomitant SAR sensitized to JCP (N = 29, BA-SAR-JCP group) and those not sensitized (N = 13, BA-AR-non-JCP group) during the JCP season. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.014DOI Listing

TSLP is a negative regulator of RANKL-induced osteoclastogenesis.

Biochem Biophys Res Commun 2020 Jun 26. Epub 2020 Jun 26.

Oral Health Science Center, Tokyo Dental College, Tokyo, 101-0061, Japan; Tokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, 101-0061, Japan; Department of Biochemistry, Tokyo Dental College, Tokyo, 101-0061, Japan.

Thymic stromal lymphopoietin (TSLP) is a member of the IL-2 cytokine family, which is known to activate type 2 innate lymphoid cells, mast cells, and Th2 cells; this activation results in allergic inflammation and host defense against parasites. TSLP has also been shown to promote Th17-mediated immune responses, such as those observed in the development of rheumatoid arthritis; however, its role in osteoclastogenesis remains poorly understood. Here, we investigated the functional involvement of TSLP in RANKL-induced osteoclast differentiation from murine bone marrow-derived macrophages (BMMs). Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.05.055DOI Listing