142,112 results match your criteria Chronic Laryngitis Infectious or Allergic

Effect of vitamin D supplementation on lung function in children with asthma and low vitamin D levels.

J Allergy Clin Immunol 2021 Jun 9. Epub 2021 Jun 9.

Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background: Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.

Objective: To determine whether vitamin D supplementation reduces levels of total IgE and IgE to each of two common indoor allergens in children with asthma and low vitamin D levels.

Methods: Total IgE, IgE to Dermatophagoides pteronyssinus (Der p), and IgE to Blattella germanica (Bla g) were measured at the randomization and exit visits for 174 participants in the Vitamin D Kids Asthma study (VDKA), a multicenter, double-blind, randomized placebo-controlled trial of vitamin D supplementation (4,000 IU/day) to prevent severe exacerbations in children with persistent asthma and vitamin D levels <30 ng/ml. Read More

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Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors.

Clin Chim Acta 2021 Jun 9. Epub 2021 Jun 9.

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, DK-4000 Roskilde, Denmark.

Background And Aims: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts.

Material And Methods: In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Read More

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Investigating the inflammatory cascade effect of basophil activation in children with allergic rhinitis or asthma, via the IgE-FcεRI-NF-κB signaling pathway.

Yi Qiao Jie Chen

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Otorhinolaryngology, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, China.

Background: Allergic rhinitis (AR) is a type I allergic reaction mediated by serum immunoglobulin E (IgE).

Objectives: This study aimed to investigate the basophil activation rate and serum expression of inflammatory factors in AR patients and rats. The involvement of the IgE-FcεRI-nuclear factor kappa B (NF-κB) signaling pathway in the pathogenesis of AR was also explored. Read More

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The B-Natural study-The outcome of immune tolerance induction therapy in patients with severe haemophilia B.

Haemophilia 2021 Jun 12. Epub 2021 Jun 12.

Indiana Haemophilia and Thrombosis Centre, Indianapolis, Indiana, USA.

Introduction: Inhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher.

Aim: To evaluate the use and outcome of ITI in patients with HB and inhibitors. Read More

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Association of Symptoms of Sleep-Related Breathing Disorders with Asthma Control in Indian Children.

Indian J Pediatr 2021 Jun 11. Epub 2021 Jun 11.

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.

Objective: To explore the association of symptoms of sleep-related breathing disorders (SRBD) with asthma control in Indian children.

Methods: This study was carried out in the pediatric chest clinic of a tertiary care center in western India. Children from 6 to 18 y of age with a physician-diagnosed case of asthma were included in the study. Read More

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Eight novel susceptibility loci and putative causal variants in atopic dermatitis.

J Allergy Clin Immunol 2021 Jun 2. Epub 2021 Jun 2.

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan; Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. Electronic address:

Background: Atopic dermatitis (AD) is the most common allergic disease in the world. While genetic components play critical roles in its pathophysiology, a large proportion of its genetic background is still unexplored.

Objectives: This study sought to illuminate the genetic associations with AD using genome-wide association study (GWAS) and its downstream analyses. Read More

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Biologics in Otolaryngology: Past, Present, and Future.

Otolaryngol Clin North Am 2021 Jun 8. Epub 2021 Jun 8.

Department of Otolaryngology - Head and Neck Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, 11th Floor Otolaryngology, Atlanta, GA 30308, USA.

Biologics have been widely adopted in multiple subspecialties of otolaryngology. This article provides an overview of past, present, and future uses of biologics in otolaryngology with emphasis on allergic rhinitis, chronic rhinosinusitis with polyposis, head and neck squamous cell carcinoma, salivary and skull base tumors, hearing loss, and other otologic disorders. Read More

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Dual inhibition of complement component 5 and leukotriene B4 by topical rVA576 in atopic keratoconjunctivis: TRACKER phase 1 clinical trial results.

Orphanet J Rare Dis 2021 Jun 11;16(1):270. Epub 2021 Jun 11.

Moorfields Eye Hospital, 51 North Block, 5 Chicheley Street, London, SE1 7PJ, UK.

Purpose: To evaluate the safety and preliminary efficacy of topical rVA576, a dual inhibitor of complement component 5 (C5) and leukotriene B4 (LTB4), in patients with recalcitrant atopic keratoconjunctivitis (AKC) in the open label phase 1 TRACKER clinical trial.

Methods: Three patients diagnosed with moderate or severe AKC who had been on maximal topical treatment (antihistamines and ciclosporin) for at least three months prior to entry, and showed persistent symptoms and signs of inflammation, were recruited into the trial. Patients received rVA576 eye drops twice a day for 8 weeks. Read More

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Management of penicillin allergy in primary care: a qualitative study with patients and primary care physicians.

BMC Fam Pract 2021 Jun 11;22(1):112. Epub 2021 Jun 11.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, UK.

Background: Six percent of patients are allergic to penicillin according to their medical records. While this designation protects a small number of truly allergic patients from serious reactions, those who are incorrectly labelled may be denied access to recommended first line treatment for many infections. Removal of incorrect penicillin allergy may have positive health consequences for the individual and the general population. Read More

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Analysis of allergen profile in patients sensitized to canine allergen and potential Can f 5 cross-reactivity with human PSA.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211023670

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.

Can f 5 allergy and possible cross-reactivity with human semen in which there are significant amounts of prostate-specific antigen (PSA) are particularly interesting aspects of allergy to dog. The objective of the study was to confirm cross-reactivity between human PSA and Can f 5 in a study of canine sensitised women. A total of 100 women (aged 18-73, 41 on average) with a positive history of animal fur allergy or positive skin prick tests to canine allergens were selected. Read More

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Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota.

Food Funct 2021 Jun 12. Epub 2021 Jun 12.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University (Guangzhou Campus), Guangzhou, China. and Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, China.

Dietary factors can reshape the gut microbiota and consequently affect disease progression. We previously reported that tetrahydrocurcumin (THC), the major active metabolite of curcumin (Cur), could ameliorate allergic inflammation in asthmatic mice. Herein, we aimed to investigate whether THC or Cur exerts anti-inflammatory effects on allergic asthma via modulating gut microbiota. Read More

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Platelet Activating-Factor Acetylhydrolase II:A Member of Phospholipase A2 Family That Hydrolyzes Oxidized Phospholipids.

Chem Phys Lipids 2021 Jun 8:105103. Epub 2021 Jun 8.

Department of TCM Chemistry, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Intracellular platelet activating-factor acetylhydrolase type II (PAF-AH II) is a 40-kDa monomeric enzyme. It was originally identified as an enzyme that hydrolyzes the acetyl group of PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine). As a member of phospholipase A2 super family, PAF-AH II has broad substrate specificity. Read More

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Early postnatal exposure to traffic-related air pollution and asthma in adolescents: Vulnerability factors in the PARIS birth cohort.

Environ Res 2021 Jun 8:111473. Epub 2021 Jun 8.

Health Environmental Risk Assessment (HERA) Team, CRESS, Université de Paris, Inserm, INRAE, Paris, France; Université de Paris, Faculté de Pharmacie de Paris, Paris, France; Cellule Cohorte, Direction de l'Action Sociale de l'Enfance et de la Santé, Mairie de Paris, Paris, France.

Background: Associations between early traffic-related air pollution (TRAP) exposure and respiratory and allergic morbidity in adolescents are inconsistent. However, sub-groups might be more vulnerable to the health effects of this exposure.

Objectives: We investigated associations between early exposure to TRAP and respiratory and allergic morbidity at age 13 years in the PARIS birth cohort, and potential modifying effects of sex, parental allergy, stressful family event and lower respiratory tract infections (LRTI). Read More

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Characterising non-linear associations between airborne pollen counts and respiratory symptoms from the AirRater smartphone app in Tasmania, Australia: A case time series approach.

Environ Res 2021 Jun 8;200:111484. Epub 2021 Jun 8.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia; Public Health Services, Department of Health, Hobart, TAS, 7000, Australia. Electronic address:

Pollen is a well-established trigger of asthma and allergic rhinitis, yet concentration-response relationships, lagged effects, and interactions with other environmental factors remain poorly understood. Smartphone technology offers an opportunity to address these challenges using large, multi-year datasets that capture individual symptoms and exposures in real time. We aimed to characterise associations between six pollen types and respiratory symptoms logged by users of the AirRater smartphone app in Tasmania, Australia. Read More

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A decision tree model for neuroimmune guidance of allergic immunity.

Immunol Cell Biol 2021 Jun 11. Epub 2021 Jun 11.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

The immune system defends the body from infectious and non-infectious threats. Distinct recognition strategies have evolved to generate antigen-specific immunity against pathogens or toxins versus antigen-independent tissue repair. Structural recognition, or the sensing of conserved motifs, guides the immune response to viruses, bacteria, fungi, and unicellular parasites. Read More

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Trends in Patch Testing in the Medicare Part B Fee-for-Service Population.

Dermatitis 2021 Jun 9. Epub 2021 Jun 9.

From the University of Minnesota Medical School Biostatistical Design and Analysis Center, Clinical and Translational Science Institute Division of Healthy Policy and Management, School of Public Health, University of Minnesota Department of Dermatology, University of Minnesota, Minneapolis Veterans Affairs Health Care System Departments of Medicine Dermatology, University of Minnesota Departments of Medicine Dermatology, Minneapolis Veterans Affairs Health Care System, MN.

Background: Patch testing is a vital component of the workup for allergic contact dermatitis. There are limited data on changes of patch testing use among Medicare providers, as well as patch testing reimbursement rates.

Objective: The aim of the study was to evaluate trends in the use of patch testing among various Medicare providers and Medicare patch testing reimbursement. Read More

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Contact Allergens in Prescription Topical Ophthalmic Medications.

Dermatitis 2021 Jun 9. Epub 2021 Jun 9.

From the Department of Dermatology, Park Nicollet Health Services University of Minnesota Medical School, Minneapolis.

Background/objective: Both active and inactive ingredients in topical ophthalmic agents may cause allergic contact dermatitis. Here, we examined ingredients in prescription topical ophthalmic medications available in the United States.

Methods: A comprehensive list of topical ophthalmic medications was generated using AccessPharmacy. Read More

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Further Evidence of Allergic Contact Dermatitis Caused by 2,2'-Methylenebis(6-tert-Butyl-4-Methylphenol) Monoacrylate, a New Sensitizer in the Dexcom G6 Glucose Sensor.

Dermatitis 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden Department of Dermatology, Helsingborg Hospital, Helsingborg, Sweden.

Background: Since the spring of 2020, we have seen several patients experiencing severe allergic contact dermatitis (ACD) from the Dexcom G6 glucose sensor after the composition of the sensor's adhesive patch had been changed. We have previously reported the finding of a new sensitizer, 2,2'-methylenebis(6-tert-butyl-4-methylphenol) monoacrylate, in the Dexcom G6 adhesive patch. Three patients with ACD from Dexcom G6 tested positive to this sensitizer. Read More

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Lipid transfer protein syndrome due to wild grape juice and various vegetables: A life-threatening food allergen.

J Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Iwate Medical University School of Medicine, Shiwa-gun, Japan.

We report a 16-year-old Japanese male with mugwort pollinosis in whom ingestion of wild grape juice and various vegetables caused recurrent general urticaria, abdominal pain, dyspnea, and loss of consciousness. A skin prick test demonstrated positive reactions to a wide variety of both non-heated and heated vegetables and fruits such as wild grape, bell pepper, onion, Chinese cabbage, tomato, eggplant, and broccoli. The serum immunoglobulin E levels (ImmunoCAP ISAC ) for Art v 3, Pla a 3, Pru p 3, and Jug r 3, which are lipid transfer protein (LTP) homologs, were positive but those for Bet v 1 and Bet v 2 were negative. Read More

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A rare case of allergic fungal rhinosinusitis in Indonesian elderly: A case report and diagnostic procedure.

Ann Med Surg (Lond) 2021 Jun 21;66:102400. Epub 2021 May 21.

Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Allergic fungal rhinosinusitis (AFRS) is a rare case.

Case Presentation: A 63-year-old-man presented right nasal congestion one year ago. There was a polyp in the right nasal cavity supported CTScan showed a solid mass with central hyperattenuating of ±8. Read More

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Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics.

Dis Markers 2021 19;2021:5558458. Epub 2021 May 19.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, Hunan, China.

The aim of this study was to identify differences in serum metabolomics profiles of house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared to controls and to explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy controls and HDM-induced 72 AR patients, including 30 mild patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomics detection was performed, and orthogonal partial least square discriminate analysis was applied to assess the differences between AR patients and controls and for subgroups based on disease severity. Read More

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Cryoglobulins, Cryofibrinogens, and Cold Agglutinins in Cold Urticaria: Literature Review, Retrospective Patient Analysis, and Observational Study in 49 Patients.

Front Immunol 2021 25;12:675451. Epub 2021 May 25.

Department of Dermatology and Allergy, Dermatological Allergology, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Introduction: Cryoproteins, such as cryoglobulins, cryofibrinogens and cold agglutinins, precipitate at low temperatures or agglutinate erythrocytes and dissolve again when warmed. Their pathogenetic and diagnostic importance in cold urticaria (ColdU) is unclear. In this study, we aimed to characterize the prevalence of cryoproteins in patients with ColdU. Read More

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Current approach to the diagnosis of allergic bronchopulmonary aspergillosis.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2546

Division of Allergy and Clinical Immunology, Department of Chest Diseases, Erciyes University School of Medicine, Kayseri, Turkey. Electronic address:

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Reply to "Current approach to the diagnosis of allergic bronchopulmonary aspergillosis".

J Allergy Clin Immunol Pract 2021 Jun;9(6):2546-2548

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

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Reply to "Thoracic conidiobolomycosis: Invasive or allergic?"

J Allergy Clin Immunol Pract 2021 Jun;9(6):2545-2546

Infectious Diseases Unit, Royal Children's Hospital Melbourne, Melbourne, Vic, Australia; Tropical Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Vic, Australia.

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Thoracic conidiobolomycosis: Invasive or allergic?

J Allergy Clin Immunol Pract 2021 Jun;9(6):2544-2545

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

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A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome.

Microbiome 2021 Jun 10;9(1):134. Epub 2021 Jun 10.

Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil.

The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Read More

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The comparison between children and adolescents with asthma provided by the real-world "ControL'Asma" study.

J Asthma 2021 Jun 10:1-10. Epub 2021 Jun 10.

Allergy Clinic, Department of Outpatients, Casa di Cura Villa Montallegro, Genoa, Italy.

Because asthma is a disease that changes over time, the Italian Society of Pediatric Allergy and Immunology launched a nationwide study on asthma control (the ControL'Asma study). The intent was to test the hypothesis that children with asthma could present a different pattern compared to adolescents. In the study, we compared children with adolescents in a real-world setting by analyzing the asthma control grade and other asthma-related parameters. Read More

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Thyme oil alleviates Ova-induced bronchial asthma through modulating Th2 cytokines, IgE, TSLP and ROS.

Biomed Pharmacother 2021 Jun 8;140:111726. Epub 2021 Jun 8.

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. Electronic address:

Bronchial asthma (BA) is a heterogeneous allergic respiratory disease with diverse inflammatory symptoms, pathology, and responses to treatment. Thyme is a natural product which is consisted of multiple phenolic compounds of therapeutic significance for treatment of cough and bronchitis. This study evaluated the efficacy of thyme oil against ovalbumin (OVA)-induced BA in an experimental rabbit model. Read More

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Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.

J Allergy Clin Immunol 2021 Jun 7. Epub 2021 Jun 7.

University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address:

Background: While numerous genetic loci associated atopic dermatitis (AD) have been discovered, to date, work leveraging the combined burden of AD risk variants across the genome to predict disease risk has been limited.

Objective: This study aims to determine if polygenic risk scores (PRSs) relying on genetic determinants for AD provide useful predictions for disease occurrence and severity. We also explicitly test the value of including genome wide association studies (GWASs) of related allergic phenotypes and known filaggrin (FLG) loss-of-function (LOF) variants. Read More

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