148,350 results match your criteria Chronic Laryngitis Infectious or Allergic

Food-dependent Exercise-induced Wheals, Angioedema, and Anaphylaxis: A Systematic Review.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany.

Background: Food-dependent exercise-induced wheals, angioedema, and anaphylaxis remain insufficiently characterized.

Objective: We systematically reviewed the literature on clinical manifestations, laboratory investigations, culprit foods, triggering exercise, comorbidities, and treatment outcomes.

Methods: Using predefined search terms and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) recommendations, we searched three electronic databases to identify relevant literature published before July 2021. Read More

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Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype.

Phytomedicine 2022 Jun 8;104:154252. Epub 2022 Jun 8.

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Background: Despite the substantial amount of efforts made to reduce morbidity and improve respiratory management, asthma control remained a major challenge for severe patients. Plant isoflavones, one of the most estrogenic compounds, are considered a potential alternative therapy for asthma. Iristectorigenin A, a naturally occurring isoflavone, is extracted from a variety of medical plants and its biological activity has not been reported previously. Read More

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Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Building 9312, Henrik Harpestrengs Vej 4C, 2100 Copenhagen, Denmark.

Aims: To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs).

Methods And Results: A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker. Read More

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Allergy testing for Cremophor in a patient with cervical cancer with infusion reactions to paclitaxel and docetaxel.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Obstetrics and Gynecology, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, Japan.

A woman in her 30s with cervical cancer underwent postoperative chemotherapy and showed allergic reactions to multiple taxanes. As the patient had infusion reactions to both paclitaxel and docetaxel, a prick test with Cremophor was conducted. In the absence of an allergic reaction to etoposide, we determined that the patient was allergic to pure taxane compounds. Read More

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Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation.

Chin J Nat Med 2022 Jun;20(6):443-457

Institute of Otolaryngology, Institute of Hearing and Speech of Sun Yat-sen University, Sun Yat-sen Me-morial Hospital, Sun Yat-sen University, Guangzhou 510520, China. Electronic address:

Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic rhinitis. Hence, regulating the balance of intestinal flora may be useful for preventing and treating allergic rhinitis. However, the underlying mechanism is unclear. Read More

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Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx.

Chin J Nat Med 2022 Jun;20(6):421-431

Department of Pharmacy, Jinling Hospital, Nanjing 210002, China. Electronic address:

Pseudo-allergic reactions (PARs) widely occur upon application of drugs or functional foods. Anti-pseudo-allergic ingredients from natural products have attracted much attention. This study aimed to investigate anti-pseudo-allergic compounds in licorice. Read More

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The Environmental Microbiome, Allergic Disease and Asthma.

J Allergy Clin Immunol Pract 2022 Jun 21. Epub 2022 Jun 21.

Department of Internal Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address:

The environmental microbiome represents the entirety of the microbes and their metabolites that we encounter in our environments. A growing body of evidence supports the role of the environmental microbiome in risk for and severity of allergic diseases and asthma. The environmental microbiome represents a ubiquitous, lifelong exposure to non-self antigens. Read More

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Viral infection and allergy status impact severity of asthma symptoms in children with asthma exacerbations.

Ann Allergy Asthma Immunol 2022 Jun 21. Epub 2022 Jun 21.

Department of Pediatrics, Division of Allergy and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR; Arkansas Children's Research Institute, Little Rock, AR. Electronic address:

Background: While viral infection is known to be associated with asthma exacerbations, prior research has not identified reliable predictors of acute symptom severity in virus-related asthma exacerbations (VRAE).

Objective: To determine the effect of asthma control and viral infection on the severity of current illness and evaluate biomarkers related to acute symptoms during asthma exacerbations.

Methods: We prospectively enrolled 120 children with physician diagnosed asthma and current wheezing who presented to Arkansas Children's Hospital Emergency Department. Read More

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Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis.

ACS Appl Mater Interfaces 2022 Jun 24. Epub 2022 Jun 24.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 100190, P. R. China.

Allergic rhinitis (AR) is a chronic inflammatory reaction by immunoglobulin E (IgE) mediators after individual contact with allergens. It affects 10-40% of the world's population and reduces the quality of life. Long-term symptoms of rhinitis can cause inflammation to spread and trigger asthma, which can harm human health. Read More

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White patients' physical responses to healthcare treatments are influenced by provider race and gender.

Proc Natl Acad Sci U S A 2022 Jul 27;119(27):e2007717119. Epub 2022 Jun 27.

Department of Psychology, Stanford University, Stanford, CA 94305.

The healthcare workforce in the United States is becoming increasingly diverse, gradually shifting society away from the historical overrepresentation of White men among physicians. However, given the long-standing underrepresentation of people of color and women in the medical field, patients may still associate the concept of doctors with White men and may be physiologically less responsive to treatment administered by providers from other backgrounds. To investigate this, we varied the race and gender of the provider from which White patients received identical treatment for allergic reactions and measured patients' improvement in response to this treatment, thus isolating how a provider's demographic characteristics shape physical responses to healthcare. Read More

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Eosinophilic Disorders of the Gastrointestinal Tract and Associated Abdominal Viscera: Imaging Findings and Diagnosis.

Radiographics 2022 Jun 24:220004. Epub 2022 Jun 24.

From the Department of Radiology (M.Y., A.D.T.A., Z.S.K., M.L.W., J.P.H., S.P.S., J.L.F., S.K.V.) and Department of Laboratory Medicine and Pathology (M.S.T.), Mayo Clinic, 200 2nd St SW, Rochester, MN 55905; and Department of Diagnostic Imaging, National University Health System, Singapore (L.L.S.T.).

Eosinophilic gastrointestinal disorders (EGIDs) are inflammatory conditions of the gastrointestinal tract that are characterized by tissue eosinophilia and end-organ dysfunction or damage. Primary EGIDs are associated with atopy and other allergic conditions, whereas secondary EGIDs are associated with underlying systemic diseases or hypereosinophilic syndrome. Within the spectrum of EGIDs, eosinophilic esophagitis is the most prevalent. Read More

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Identification of Major B-Cell Linear Epitopes of Peach Allergen Pru p 3 Using Immune Slot-Blot Microarray Assay.

J Agric Food Chem 2022 Jun 24. Epub 2022 Jun 24.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Foods, School of Food Science Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, People's Republic of China.

Pru p 3, one of the most representative proteins of the lipid transfer proteins (LTPs), is responsible for clinical allergic reactions to food of peach origin. The identification of Pru p 3 epitopes is not comprehensive due to different methods and principles of epitope screening. In addition, evaluation of the stability of the epitopes and the validation of the immunological key amino acids still need further research. Read More

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Exiting the Anthropocene: Achieving Personal and Planetary Health in the 21 Century.

Allergy 2022 Jun 24. Epub 2022 Jun 24.

NOVA Institute for Health, 1407 Fleet Street, Baltimore, MD 21231, USA.

Planetary health provides a perspective of ecological interdependence that connects the health and vitality of individuals, communities, and Earth's natural systems. It includes the social, political, and economic ecosystems that influence both individuals and whole societies. In an era of interconnected grand challenges threatening health of all systems at all scales, planetary health provides a framework for cross-sectoral collaboration and unified systems approaches to solutions. Read More

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Oak pollen allergy in Korea.

Curr Protein Pept Sci 2022 Jun 24. Epub 2022 Jun 24.

Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, 03722, Korea.

Oak pollen allergy is common all over the world and important causes of pollinosis. The molecular properties of some component allergens have been clearly characterized, while some of them are still waiting for the characterization. Studies on some oak component allergens are neglected, possibly because of its high cross-reactivity to birch. Read More

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Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components.

Transfusion 2022 Jun 24. Epub 2022 Jun 24.

Cerus Corporation, Concord, California, USA.

Background: Platelet transfusion carries risk of transfusion-transmitted infection (TTI). Pathogen reduction of platelet components (PRPC) is designed to reduce TTI. Pulmonary adverse events (AEs), including transfusion-related acute lung injury and acute respiratory distress syndrome (ARDS) occur with platelet transfusion. Read More

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[Translated article] Contact Allergy in Patients With Rosacea.

Actas Dermosifiliogr 2022 Jun 10;113(6):T550-T554. Epub 2022 May 10.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain.

Background And Objective: Rosacea is a chronic acneiform skin disorder in which impaired skin barrier function can lead to sensitization to allergens. We aimed to analyze contact allergies in our patients with rosacea.

Material And Methods: Retrospective cohort study of all patients who underwent patch testing in our skin allergy clinic between May 1991 and May 2019. Read More

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Nutritional management of immediate hypersensitivity to legumes in vegetarians.

Allergol Immunopathol (Madr) 2022 22;50(S Pt 1):37-45. Epub 2022 Jun 22.

Departament of Pediatrics, Division of Allergy, Clinical Immunology and Rheumatology, Escola Paulista de Medicina-Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.

Vegetarianism is becoming a common practice among people. Products of vegetable origin are also on the rise, such as vegetable "milk" and legume-based snacks, which may lead to legume sensitivity and allergies in vegetarian diet followers. Furthermore, products derived from legumes, such as lupin flour or fenugreek powder, are often used as food additives. Read More

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Efficacy and Safety of Rupatadine Fumarate Combined with Acupoint Application in Allergic Rhinitis Complicated with Diabetes.

Comput Intell Neurosci 2022 14;2022:6935758. Epub 2022 Jun 14.

Department of Otolaryngology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

The prevalence of allergic rhinitis has exhibited an upward trend, and diabetes is a common endocrine metabolic disorder. Treatment of allergic rhinitis complicated with diabetes has been marginally explored. This study aimed to observe the effect of rupatadine fumarate combined with acupoint application in the treatment of allergic rhinitis complicated with diabetes and its effect on serum IgE levels. Read More

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Lung function in young adulthood: differences between males and females with asthma.

ERJ Open Res 2022 Apr 20;8(2). Epub 2022 Jun 20.

Dept of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.

Background: There are phenotypic differences in asthma in males and females. Differences in lung function between the sexes at the peak lung function level in young adulthood are so far not directly addressed. The aim of the present study was to assess lung function in early adulthood in males and females depending on asthma onset and remission. Read More

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Emulgels Containing Seed Oil, Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment.

Polymers (Basel) 2022 Jun 9;14(12). Epub 2022 Jun 9.

Graduate Program in Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.

seed oil and seed oil consist of fatty acids and sterols that are beneficial for skin. Mixing of these oils at 1:1 ratio has shown to increase antioxidant activity of oils. This study aims to formulate emulgels containing microemulsions of seed oil, seed oil, and mixed and seed oils. Read More

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Maternal High-Fat Diet Aggravates Allergic Asthma in Offspring via Modulating CD4 T-Cell Differentiation.

Nutrients 2022 Jun 16;14(12). Epub 2022 Jun 16.

Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China.

Maternal improper nutrition has been reported to trigger respiratory disorders in offspring. Here, we characterized the effects of high-fat environment in the fetal period on mice and human cord blood CD4 T-lymphocytes, and investigated their roles in susceptibility to asthma. Mice born to mothers that consumed a high-fat diet (HFD) throughout the gestation period were sensitized by ovalbumin to establish an experimental asthma model. Read More

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Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo.

Molecules 2022 Jun 12;27(12). Epub 2022 Jun 12.

Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Yunnan University of Chinese Medicine, Kunming 650500, China.

Renifolin F is a prenylated chalcone isolated from , a traditional minority ethnic medicine used to treat the respiratory diseases and asthma. Based on the effects of the original medicine plant, we established an in vivo mouse model of allergic asthma using ovalbumin (OVA) as an inducer to evaluate the therapeutic effects of Renifolin F. In the research, mice were sensitized and challenged with OVA to establish an allergic asthma model to evaluate the effects of Renifolin F on allergic asthma. Read More

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mRNA BNT162b Vaccine Elicited Higher Antibody and CD4 T-Cell Responses than Patients with Mild COVID-19.

Microorganisms 2022 Jun 18;10(6). Epub 2022 Jun 18.

Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

We compared the development and persistence of antibody and T-cell responses elicited by the mRNA BNT162b2 vaccine or SARS-CoV-2 infection. We analysed 37 post-COVID-19 patients (15 with pneumonia and 22 with mild symptoms) and 20 vaccinated subjects. Anti-Spike IgG and neutralising antibodies were higher in vaccinated subjects and in patients with pneumonia than in patients with mild COVID-19, and persisted at higher levels in patients with pneumonia while declining in vaccinated subjects. Read More

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The Role of Early Life Microbiota Composition in the Development of Allergic Diseases.

Microorganisms 2022 Jun 9;10(6). Epub 2022 Jun 9.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun 130062, China.

Allergic diseases are becoming a major healthcare issue in many developed nations, where living environment and lifestyle are most predominantly distinct. Such differences include urbanized, industrialized living environments, overused hygiene products, antibiotics, stationary lifestyle, and fast-food-based diets, which tend to reduce microbial diversity and lead to impaired immune protection, which further increase the development of allergic diseases. At the same time, studies have also shown that modulating a microbiocidal community can ameliorate allergic symptoms. Read More

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Early Use of ECMO for Refractory Kounis Syndrome Concealed by General Anesthesia-A Case Report.

Medicina (Kaunas) 2022 Jun 2;58(6). Epub 2022 Jun 2.

Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital 11, Samjeongja-ro, Seongsan-gu, Changwon-si 51472, Korea.

A 46-year-old woman demonstrated refractory Kounis syndrome (KS) after induction of anesthesia. Despite conventional management of anaphylaxis and advanced cardiac life support, her cardiovascular function continued to deteriorate until she had a cardiac arrest, and after extracorporeal membrane oxygenation (ECMO) therapy, electrical cardiac activity reappeared. A large number of patients with KS-"allergic angina syndrome"-has been known to recover well with vasodilators; however, this patient showed antibiotics-induced refractory KS during general anesthesia. Read More

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Anti-Inflammatory Effects of Cicadidae Periostracum Extract and Oleic Acid through Inhibiting Inflammatory Chemokines Using PCR Arrays in LPS-Induced Lung inflammation In Vitro.

Life (Basel) 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Herbology, College of Korean Medicine, Sangji University, 83, Sangjidae-gil, Wonju-si 26339, Korea.

In this study, we aimed to evaluate the anti-inflammatory effects and mechanisms of CP and OA treatments in LPS-stimulated lung epithelial cells on overall chemokines and their receptors using PCR arrays. In addition, we aimed to confirm those effects and mechanisms in LPS-stimulated lung macrophages on some chemokines and cytokines. In our study, CP treatments significantly inhibited the inflammatory mediators CCL2, CCL3, CCL4, CCL5, CCL6, CCL9, CCL11, CCL17, CCL20, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7, CXCL10, TNF-α, and IL-6, while markedly suppressing NF-κB p65 nuclear translocation and the phosphorylations of PI3K p55, Akt, Erk1/2, p38, and NF-κB p65 in LPS-stimulated lung epithelial cells. Read More

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Ameliorative Effect of a Neoteric Regimen of Catechin plus Cetirizine on Ovalbumin-Induced Allergic Rhinitis in Rats.

Life (Basel) 2022 May 31;12(6). Epub 2022 May 31.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, El-Minia 61511, Egypt.

Allergic rhinitis (AR) affects 20-50% of the global population. Available treatments are limited by their adverse effects. We investigated the anti-allergic effects of catechin alone and combined with cetirizine against ovalbumin-induced AR. Read More

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The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review.

J Pers Med 2022 Jun 9;12(6). Epub 2022 Jun 9.

Unit of Otorhinolaryngology Head and Neck Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Previous studies have demonstrated that both subcutaneous (SCIT) and sublingual specific immunotherapy (SLIT) are effective in treating allergic rhinitis (AR). Further studies have evaluated the efficacy of allergen-specific immunotherapy (AIT) on different ear, nose, and throat (ENT) manifestations, in which allergy might have an etiopathogenetic role, such as local allergic rhinitis (LAR), rhinosinusitis (RS), otitis media (OM), and adenotonsillar (AT) disease. Nevertheless, the management of allergy in ENT diseases is still debated. Read More

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From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine.

J Pers Med 2022 May 28;12(6). Epub 2022 May 28.

La Roche-Posay International, 92300 Levallois-Perret, France.

Atopic dermatitis (AD) affects up to 20% of children and is considered the starting point of the atopic march with the development of food allergy, asthma, and allergic rhinitis. The heterogeneous phenotype reflects distinct and/or overlapping pathogenetic mechanisms with varying degrees of epidermal barrier disruption, activation of different T cell subsets and dysbiosis of the skin microbiome. Here, we review current evidence suggesting a systemic impact of the cutaneous inflammation in AD together with a higher risk of asthma and other comorbidities, especially in severe and persistent AD. Read More

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Immunological Pathomechanisms of Spongiotic Dermatitis in Skin Lesions of Atopic Dermatitis.

Int J Mol Sci 2022 Jun 15;23(12). Epub 2022 Jun 15.

Department of Geriatric Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakaecho, Tokyo 173-0015, Japan.

Atopic dermatitis (AD) is a chronic pruritic skin disease with a complex pathogenesis underlying its heterogeneous clinical phenotypes and endotypes. The skin manifestation of AD reflects the cytokine milieu of a type-2-dominant immunity axis induced by genetic predisposition, innate immunity dysregulation, epidermal barrier defects, and allergic inflammation. However, the detailed pathomechanism of eczematous dermatitis, which is the principal characteristic of AD, remains unclear. Read More

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