128,784 results match your criteria Chronic Laryngitis Infectious or Allergic


Chronic Rhinosinusitis: Does Allergy Play a Role?

Med Sci (Basel) 2019 Feb 18;7(2). Epub 2019 Feb 18.

Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, GA 30308, USA.

A few chronic rhinosinusitis (CRS) variants have demonstrated a strong association with environmental allergy, including allergic fungal rhinosinusitis (AFRS) and central compartment atopic disease (CCAD). However, the overall relationship between CRS and allergy remains poorly defined. The goal of this review is to evaluate the relationship between CRS and allergy with a focus on specific CRS variants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medsci7020030DOI Listing
February 2019

IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Pneumology & Pulmonary Cell Research, Departments of Internal Medicine & Biomedicine, University & University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

The patho-mechanism leading to airway wall remodeling in allergic asthma is not well understood and remodeling is resistant to therapies. This study assessed the effect of immunoglobulin E (IgE) in the absence of allergens on human primary airway smooth muscle cell (ASMC) remodeling in vitro. ASMCs were obtained from five allergic asthma patients and five controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20040875DOI Listing
February 2019

A Novel Dantrolene Sodium-Loaded Mixed Micelle Containing a Small Amount of Cremophor EL: Characterization, Stability, Safety and Pharmacokinetics.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Beijing Key laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Dantrolene sodium (DS) is the only drug specifically used for the treatment of malignant hyperthermia. Nevertheless, its clinical application is significantly restricted due to its aqueous insolubility and the limited formulations available in clinical practice. In order to solve these problems, a novel mixed micelle composed of phospholipid and Cremophor EL was designed and evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24040728DOI Listing
February 2019

Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Department of Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Qalyubia 13518, Egypt.

This study was designed to investigate the potential effects and underlying mechanism of adipose tissue-derived mesenchymal stem cells (MSCs) on allergic inflammation compared to Montelukast as an antileukotriene drug in a rat model of allergic rhinitis (AR). The effect of MSCs was evaluated in albino rats that were randomly divided into four (control, AR, AR + Montelukast, and AR + MSCs) groups. Rats of AR group were sensitized by ovalbumin (OVA) and then challenged with daily nasal drops of OVA diluted in sterile physiological saline (50 μL/nostril, 100 mg/mL, 10% OVA) from day 15 to day 21 of treatment with/without Montelukast (1 h before each challenge) or MSCs I/P injection (1 × 10⁶ MCSs; weekly for three constitutive weeks). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20040873DOI Listing
February 2019

The effect of passive smoking on exhaled nitric oxide in asthmatic children.

Nitric Oxide 2019 Feb 16. Epub 2019 Feb 16.

Social Medicine Institute, Department of Social and Preventive Medicine, Medical University of Lodz, Poland.

To date, some studies suggest that passive smoking (PS) may be an important determinant of FeNO levels in children but sill there is a need of investigations using objective methods of PS exposure. The aim of our study was to examine the effect of PS, measured by urine cotinine levels, on FeNO and lung function (FEV1) in allergic and non-allergic asthmatic children. METHODS: It was a prospective, non-interventional study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2019.01.012DOI Listing
February 2019

San Antonio refugees: Their demographics, healthcare profiles, and how to better serve them.

PLoS One 2019 19;14(2):e0211930. Epub 2019 Feb 19.

The San Antonio Refugee Health Clinic, The Student-Faculty Collaborative Practices Program, The Center for Medical Humanities and Ethics, The Long School of Medicine, The University of Texas Health San Antonio, San Antonio, Texas, United States of America.

Objective: The recent refugee crisis has resulted in the largest burden of displacement in history, with the US being the top resettlement country since 1975. Texas welcomed the second most US-bound refugees in 2016, with a large percentage arriving in San Antonio. Yet, the composition of the San Antonio refugees has not been described and their healthcare needs remain ill-defined. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211930PLOS
February 2019

Epistaxis Risk Associated with Intranasal Corticosteroid Sprays: A Systematic Review and Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 19:194599819832277. Epub 2019 Feb 19.

1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.

Objective: Intranasal corticosteroids (INCSs) are widely utilized for the treatment of allergic rhinitis. Epistaxis is a known adverse effect of INCSs, but it is not known if the risk of epistaxis differs among INCSs.

Data Sources: Systematic review of primary studies identified through Medline, Embase, Web of Science, PubMed Central, and Cochrane databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0194599819832277DOI Listing
February 2019

Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study.

Vet Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, NC, 27606, USA.

Background: Histamine type-1 (H1) receptor antagonists such as diphenhydramine are frequently used for treatment of pruritus in dogs, yet therapeutic efficacy for allergic disorders is reported to be highly variable. Dimenhydrinate is a salt of diphenhydramine and 8-chlorotheophylline, and has been reported to produce superior oral absorption of diphenhydramine.

Hypothesis/objective: To determine the pharmacokinetic and pharmacodynamic properties of diphenhydramine in dogs after intravenous (1 mg/kg) and oral (5 mg/kg) administration, and when given orally as dimenhydrinate at a dose of 10 mg/kg (≈5 mg/kg diphenhydramine). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vde.12727DOI Listing
February 2019
1 Read

Asthma with multiple allergic comorbidities is associated with complete response to omalizumab.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

AP-HP, Groupe hospitalier Trousseau, La Roche Guyon, Centre de l'Asthme et des Allergies, Paris, France.

Patients with severe asthma constitute a heterogeneous population, and different phenotypes have been identified both in adults and children. Severe asthma affects 4.5% of children with current asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cea.13373DOI Listing
February 2019

A new source for isothiazolinone contact allergy in traditional, non-digital photography.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, University of Montpellier, France.

A 61-year-old patient was referred for a one-year history of relapsing itchy erythematous and vesicular lesions on the dorsa of the hands progressively extending to the neck, the neckline and the face (fig 1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cod.13245DOI Listing
February 2019

Occupational allergic contact dermatitis to sulfite in a seafood section worker of a supermarket.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Service de Dermatologie, CHU Montpellier, Université Montpellier I, Montpellier, France.

A 56-year-old female patient was referred for itchy face dermatitis of a few months duration (fig 1). She had had allergic contact dermatitis to cheap jewellery and to an antifungal cream (Kétoderm) and was regularly using cosmetics for vascular rosacea. This article is protected by copyright. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cod.13244DOI Listing
February 2019

Contact Allergy and Allergic Contact Dermatitis to Lavender: A Retrospective Study from an Australian Clinic.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Skin and Cancer Foundation Inc, Occupational Dermatology Research and Education Centre, Carlton, Victoria, Australia.

Background: Lavender is commonly used in aromatherapy and in a broad range of personal and household products. It has been identified as a contact sensitizer and has been reported to cause allergic contact dermatitis (ACD).

Objectives: To report our experience with contact allergy and ACD to lavender and to raise awareness of lavender as a potential contact allergen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cod.13247DOI Listing
February 2019

T lymphocyte phenotype of contact allergic patients: experience with nickel and p-phenylenediamine.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Faculty of Biology, Medicine and Health, University of Manchester.

Background: There is considerable interest in understanding the immunological variables that have the greatest influence on the effectiveness of sensitization by contact allergens, particularly in the context of developing new paradigms for risk assessment of novel compounds OBJECTIVES: To examine the relationship between patch test score for 3 different contact allergens and the characteristics of T-cell responses.

Patients/materials/methods: A total of 192 patients with confirmed nickel, p-phenylenediamine (PPD) or methylisothiazolinone allergy were recruited from the Contact Dermatitis Investigation Unit at Salford Royal Hospital. Severity of allergy was scored by patch testing and peripheral blood lymphocytes characterized for T cell phenotype by flow cytometry and proliferative activity by radiolabelled thymidine incorporation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cod.13246DOI Listing
February 2019

Intestinal overexpression of IL-18 promotes eosinophils-mediated allergic disorders.

Immunology 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine, New Orleans, LA, 70112.

Baseline eosinophils reside in the gastrointestinal tract; however, in several allergic disorders, excessive eosinophils accumulate in the blood as well in the tissues. Recently, we showed in vitro that interleukin (IL)-18 matures and transforms IL-5 generated eosinophils into the pathogenic eosinophils that are detected in human allergic diseases. To examine the role of local induction of IL-18 in promoting eosinophil-associated intestinal disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imm.13051DOI Listing
February 2019

Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants.

Inflammopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, University of California, Los Angeles, CA, 90024, USA.

1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred with lymphoid cells from actively immunized donor rats to normal syngeneic rats = passive recipients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10787-019-00565-wDOI Listing
February 2019

How important is oxygen titration in hypercapnic COPD exacerbation?

Wien Klin Wochenschr 2019 Feb 18. Epub 2019 Feb 18.

Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00508-019-1464-yDOI Listing
February 2019

Changes among TGF-β1 Breg cells and helper T cell subsets in a murine model of allergic rhinitis with prolonged OVA challenge.

Int Immunopharmacol 2019 Feb 15;69:347-357. Epub 2019 Feb 15.

Department of Otolaryngology of Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, China. Electronic address:

Background: Allergic rhinitis is a common allergic disease resulting from inappropriate Th2 cell-mediated immune responses to environmental antigens. As such, regulatory B cells and T helper cells play a critical role in the occurrence and development of allergic rhinitis.

Methods: Wild-type mice received ovalbumin (OVA) intranasal challenge for varied lengths of time, then the inflammatory state of their nasal mucosa was analyzed by histology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.009DOI Listing
February 2019

AAAAI/ACAAI subcutaneous immunotherapy (SCIT) surveillance study (2013-2017): fatalities, infections, delayed reactions and use of epinephrine auto-injectors.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Immunology, Allergy, and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and Bernstein Clinical Research Center, Cincinnati, Ohio.

Background: SCIT is highly effective but safety risks exist.

Objective: The aims of this study were to: 1) identify clinical practices that could influence fatal and non-fatal systemic allergic reactions (SRs) to SCIT; and 2) identify SCIT-associated infections.

Methods: From 2008-2016, 27-51% of AAAAI/ACAAI members completed an annual survey of SCIT-related SRs of varying severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.01.058DOI Listing
February 2019

Low cross-reactivity between cisplatin and other platinum salts.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Dermatology Department, Dijon University Hospital, Dijon, France.

Background: Hypersensitivity reactions to platinum salts (PS) (cisplatin (CI), carboplatin (CA) and oxaliplatin (OX)) can be severe and their incidence is increasing due to their widespread use in cancer treatment.

Objective: To determine the rate of cross-reactivity between platinum salts and whether CI can be administered without prior allergy testing in patients with a history of CA or OX hypersensitivity.

Methods: From September 2002 to April 2016, patients with suspected immediate PS hypersensitivity were tested and cross-reactivity between the three PS was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.01.057DOI Listing
February 2019

Adverse events in oral immunotherapy for the desensitization of cow's milk allergy in children: a randomized controlled trial.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Allergy and Immunology, Department of Pediatrics, McGill University, Montreal, QC, Canada. Electronic address:

Background: This study focuses on side effects of cow's milk oral immunotherapy (CM-OIT) using consensus definitions of food-induced anaphylaxis.

Objective: To evaluate the risk of allergic reactions (ARs) and to identify risk factors associated with higher risk of anaphylactic ARs (AARs) during CM-OIT in children.

Methods: Clinical charts of children receiving CM-OIT were carefully reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.02.007DOI Listing
February 2019

House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation.

Microb Pathog 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. Electronic address:

Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of the most common indoor allergens and are a significant driver of allergic disease. Respiratory infections are known factors in acute exacerbations of asthma but the impact of allergen on the pathogen is not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2019.02.019DOI Listing
February 2019

Nasal IgE Production in Allergic Rhinitis: Impact of Rhinovirus Infection.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Departments of Medicine, University of Virginia Health System, Charlottesville, VA, 22908.

Background: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state and these exacerbations can be mitigated via administration of anti-IgE.

Objective: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV.

Methods: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cea.13372DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Identification of microbial contaminants in sinus rinse squeeze bottles used by allergic rhinitis patients.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 5;5(1):26-29. Epub 2019 Jan 5.

Medical University of South Carolina, Department of Otolaryngology, Head & Neck Surgery, Charleston, SC, USA.

Objective: To identify whether irrigation devices become contaminated when used by patients with allergic rhinitis (AR).

Methods: Ten AR patients with no clinical or endoscopic evidence of active sinonasal infection were given a sinus rinse system and instructed on its proper use, cleaning, and storage. Two squeeze bottles (bottle A and bottle B) were given to each patient for twice-a-day rinsing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wjorl.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364664PMC

Health-related quality of life worsens by school age amongst children with food allergy.

Clin Transl Allergy 2019 7;9:10. Epub 2019 Feb 7.

1The Centre for Allergy Research, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.

Background: Food allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such, we aimed to identify if age, as well as other factors, are associated with food allergy-specific HRQL in an objectively defined population of children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13601-019-0244-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366088PMC
February 2019

Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study.

J Asthma Allergy 2019 25;12:43-58. Epub 2019 Jan 25.

Respiratory, US Medical Affairs, GSK, La Jolla, CA, USA.

Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy.

Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan Commercial Database. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/real-world-characteristics-and-dis
Publisher Site
http://dx.doi.org/10.2147/JAA.S189676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354698PMC
January 2019
3 Reads

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019

The environment and its effect on allergic sensitization and atopic dermatitis, and colostrum and the immune system of the preterm infant.

Pediatr Allergy Immunol 2019 Mar;30(2):147-148

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13029DOI Listing

Ethanol Lock Therapy for the Prevention of Nontunneled Catheter-Related Bloodstream Infection in Pediatric Patients.

JPEN J Parenter Enteral Nutr 2019 Feb 17. Epub 2019 Feb 17.

Division of Anesthesiology and Postgraduate Program in Palliative Care, IMIP, Recife, Pernambuco, Brazil.

Background: Ethanol lock therapy (ELT) has been reported as being effective in preventing central line-associated bloodstream infection (CLABSI) in tunneled (or long-term) central venous catheters (CVCs). To the best of our knowledge, no studies have evaluated this therapy in relation to nontunneled (or short-term) CVCs.

Objective: To evaluate the effectiveness of ELT in preventing CLABSI in nontunneled CVC in pediatric patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jpen.1508DOI Listing
February 2019

N,N-dimethylacrylamide - a new sensitizer in the FreeStyle Libre glucose sensor.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Lund University, Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Sweden.

Background: Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre glucose sensor. Analyses by gas chromatography-mass spectrometry (GC-MS) have indicated the presence of N,N-dimethylacrylamide (DMAA) in the sensor.

Material And Methods: Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cod.13243
Publisher Site
http://dx.doi.org/10.1111/cod.13243DOI Listing
February 2019
7 Reads

[Clinicopathological characteristics and diagnosis of IgG4related sialadenitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):1-3

Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.001DOI Listing
February 2019
1 Read

Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.

J Vet Med Sci 2019 Feb 15. Epub 2019 Feb 15.

The Institute of Environmental Toxicology.

The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC+PARA exposure compared to that of the control, MXC, and PARA groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1292/jvms.18-0641DOI Listing
February 2019

Regulation of the pleiotropic effects of tissue resident mast cells.

J Allergy Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Clinical Nutrition, University of Hohenheim, Fruwirthstr. 12, D-70599 Stuttgart, Germany. Electronic address:

Mast cells, best known for their detrimental role in allergic diseases, act in a diverse array of physiological and pathological functions, made possible by the plurality of mast cell types. Their various developmental avenues and their distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting in diverse functions. We briefly summarize this heterogeneity, elaborate on molecular determinants that allow mast cells to communicate with their environment to fulfill their tasks, discuss their protease repertoire stored in secretory lysosomes, and consider different aspects of mast cell signaling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.02.004DOI Listing
February 2019
2 Reads

Successful treatment with omalizumab of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis: case reports and literature review.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.01.056DOI Listing
February 2019

Clinical Risk Factors Associated with Multidrug-Resistant Tuberculosis (MDR-TB) in Mali.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

University Clinical Research Center (UCRC)- SEREFO Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. Electronic address:

Background: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.02.004DOI Listing
February 2019

Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population.

Int J Pediatr Otorhinolaryngol 2019 Feb 5;120:58-63. Epub 2019 Feb 5.

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:

Objectives: Asthma and allergic rhinitis (AR) frequently occur as comorbid diseases of the upper airways. Single-nucleotide polymorphisms (SNPs) in the FCRL3 and FCRL5 genes have recently been shown to be associated with various immune-related disorders. This study evaluated the association of FCRL3 and FCRL5 polymorphisms with asthma and allergic rhinitis (AR) in a Han Chinese population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2019.02.015DOI Listing
February 2019

Cough in exercise and athletes.

Pulm Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Canada.

In the general population, particularly in individuals with asthma, cough is a common symptom, often reported after exertion, although regular exercise may be associated with a reduction in the prevalence of cough. In athletes, exercise-induced cough is also a particularly frequent symptom. The main etiologies of cough in athletes are somewhat similar to non-athletes, including asthma/airway hyperresponsiveness, upper airways disorders such as allergic or non-allergic rhinitis, and exercise-induced laryngeal obstruction, although these conditions are more frequently observed in athletes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pupt.2019.02.003DOI Listing
February 2019

Cromolyn-crosslinked chitosan nanoparticles for the treatment of allergic rhinitis.

Eur J Pharm Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy and Biotechnology, Via San Donato 19/2, University of Bologna, 40127 Bologna, Italy. Electronic address:

The aim of this work was to prepare new mucoadhesive nasal decongestant nanoparticles obtained by direct crosslinking between the cationic polymer chitosan and the anionic drug cromolyn. Different chitosan/cromolyn molar ratios were used in order to obtain nanoparticles of suitable size, encapsulation efficiency/drug loading and mucoadhesion. Moreover, the ability of the nanoparticles to deliver cromolyn into and through the nasal mucosa was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2019.02.015DOI Listing
February 2019

Allergen Immunotherapy for IgE-Mediated Food Allergy: there is a measure in everything to a proper proportion of therapy.

Pediatr Allergy Immunol 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Allergology Unit, Department of Pediatric Medicine, Bambino Gesù Children's research Hospital (IRCCS), Rome, Holy See, Italy.

IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (e. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pai.13042
Publisher Site
http://dx.doi.org/10.1111/pai.13042DOI Listing
February 2019
3 Reads

Acute Non-Traumatic Spontaneous Auricular Hematoma.

Am J Case Rep 2019 Feb 16;20:204-206. Epub 2019 Feb 16.

Department of Emergency Medicine, Mayo Clinic, Jacksonville, FL, USA.

BACKGROUND Auricular hematomas are well-known among wrestlers and other contact sports participants, but spontaneous auricular hematomas are rare. The differential diagnosis for acute spontaneous auricular swelling is limited. In addition to infectious causes, antecedent trauma, and bleeding complications, angioedema should also be considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.913464DOI Listing
February 2019

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in mice and humans. This new wealth of knowledge has uncovered novel aspects of the pathogenesis of a range of disorders, including infectious, neoplastic, autoimmune, allergic and cardiovascular diseases. Consequently, GM-CSF and IL-3 are now being investigated as therapeutic targets for some of these disorders, and some phase I/II clinical trials are already showing promising results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20040834DOI Listing
February 2019

High dietary fat intake induces a microbiota signature that promotes food allergy.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Institute of Pathology, Department of Experimental Pathology, University of Bern, Bern, Switzerland. Electronic address:

Background: Diet-induced obesity and food allergies rise in tandem, but a potential cause-and-effect relationship between these diseases of affluence remains to be tested.

Objective: To test the role of high dietary fat intake, diet-induced obesity and associated changes in gut microbial community structure on food allergy pathogenesis.

Methods: Mice were fed a high fat diet (HFD) for 12 weeks prior to food allergen sensitization on an atopic dermatitis-like skin lesion followed by intra-gastric allergen challenge to induce experimental food allergy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.01.043DOI Listing
February 2019
1 Read

Interleukin-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Immunology, University Hospital Zurich, Gloriastrasse 23, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, Ramistrasse 71, 8006 Zurich, Switzerland. Electronic address:

Background: Type 2 immunity serves to resist parasitic helminths, venoms and toxins, but the role and regulation of neutrophils during type 2 immune responses is controversial. Helminth models suggested a contribution of neutrophils to type 2 immunity, whereas neutrophils are associated with increased disease severity during type 2 inflammatory disorders such as asthma.

Objective: To evaluate the impact of the prototypic type 2 cytokines interleukin-4 (IL-4) and IL-13 on human neutrophils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.01.042DOI Listing
February 2019

Birch pollen allergen immunotherapy reprograms nasal epithelial transcriptome and recovers microbial diversity.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Haartman Institute, University of Helsinki, Helsinki, Finland; Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

Nasal epithelial transcriptome is altered by the season. Birch pollen allergen immunotherapy recovers microbial community diversity and alters expression of allergy related genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.02.002DOI Listing
February 2019

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid.

FASEB J 2019 Feb 15:fj201802307R. Epub 2019 Feb 15.

Monash Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.

The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid dexamethasone (Dex) in experimental chronic AAD/asthma. Female BALB/c mice subjected to 11 wk of ovalbumin (Ova)-induced chronic AAD were intranasally administered MCA-MSCs (1 × 10 cells/mouse; once weekly on wk 10 and 11), Dex (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201802307RDOI Listing
February 2019

A Novel Oral Glutarimide Derivative XC8 Suppresses Sephadex-Induced Lung Inflammation in Rats and Acute Asthma in Guinea Pigs.

Curr Pharm Biotechnol 2019 Feb 14. Epub 2019 Feb 14.

PHARMENTERPRISES LLC, Moscow. Russian Federation.

Background: Corticosteroids are the best drug to treat asthma, however, 10% of cases are resistant to corticosteroids. Thus, new therapeutic approaches for asthma treatment are required.

Objective: To test the efficacy of a novel glutarimide derivative XC8 in a sephadex-induced lung inflammation in rats and in acute ovalbumin induced allergic asthma in guinea pigs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389201020666190215103505DOI Listing
February 2019

Multicenter Evaluation of a Novel Immunochromatographic Test for Anti-aspergillus IgG Detection.

Front Cell Infect Microbiol 2019 31;9:12. Epub 2019 Jan 31.

Aix-Marseille Université, APHM, IRD, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.

sp. fungi cause various diseases in both immunocompetent and immunocompromised patients. The most frequent disorders include chronic pulmonary aspergillosis (CPA), a life-threatening disease that affects at least 3 million people worldwide, and allergic bronchopulmonary aspergillosis (ABPA), which affects approximately 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365447PMC
January 2019

Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.

Sci Rep 2019 Feb 14;9(1):2078. Epub 2019 Feb 14.

Biomedical Sciences Institute, University of Chile School of Medicine, Independencia 1027, Independencia, Santiago, 8380453, Chile.

Airway mucus responses to subclinical infections may explain variations in progression of chronic lung diseases and differences in clinical expression of respiratory infections across individuals. Pneumocystis associates to more severe Chronic Obstructive Pulmonary Disease (COPD), asthma, respiratory distress of premature newborns, and is a consistent subclinical infection between 2 and 5 months of age when hospitalizations for respiratory cause and infant mortality are higher. This atypical fungus associates to increased mucin 5AC (MUC5AC), a central effector of Th2-type allergic inflammation, in infant lungs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-39079-4DOI Listing
February 2019

Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut.

Sci Rep 2019 Feb 14;9(1):2007. Epub 2019 Feb 14.

Department of Statistics, Computer Science, Applications "G. Parenti" (DiSIA), Florence, Italy.

Plant non-specific lipid transfer proteins type 1 (nsLTP1) are small basic proteins with a hydrophobic cavity able to host a number of different ligands: i.e. fatty acids, fatty acyl-CoA, phospholipids, glycolipids, and hydroxylated fatty acids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-38563-1DOI Listing
February 2019

Allergic bronchopulmonary aspergillosis presumably unmasked by PD-1 inhibition.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Pulmonary and Critical Care, Tower Health System, West Reading, Pennsylvania, USA.

Programmed cell death-1 (PD-1) inhibitors stimulate immune recognition of tumour cells in cancer patients, but have significant autoimmune side effects including pneumonitis. We report the case of a patient with asthma and mild eosinophilia who developed unusual pulmonary side effect of bronchiectasis, severe eosinophilia (absolute eosinophil count: 3200 c/mm) and elevated IgE levels (7050 IU/mL; normal: <164 IU/mL) 4 months into therapy with the PD-1 inhibitor pembrolizumab. Aspergillus fumigatus IgG was elevated at 15. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227814DOI Listing
February 2019