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    6816 results match your criteria Chronic Granulomatous Disease

    1 OF 137

    Johne's disease in the eyes of Irish cattle farmers: A qualitative narrative research approach to understanding implications for disease management.
    Prev Vet Med 2017 Jun 8;141:7-13. Epub 2017 Apr 8.
    School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
    Bovine Johne's Disease (JD) is a disease characterised by chronic granulomatous enteritis which manifests clinically as a protein-losing enteropathy causing diarrhoea, hypoproteinaemia, emaciation and, eventually death. Some research exists to suggest that the aetiologic pathogen Mycobacterium avium subspecies paratuberculosis may pose a zoonotic risk. Nationally coordinated control programmes have been introduced in many of the major milk producing countries across the world. Read More

    X-linked Carriers of Chronic Granulomatous Disease: Illness, Lyonization and Stability.
    J Allergy Clin Immunol 2017 May 17. Epub 2017 May 17.
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH. Electronic address:
    Background: Chronic granulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and aberrant inflammation. Mutations in CYBB cause X-linked CGD and account for 65%-70% of cases in western countries.

    Objective: To understand the clinical manifestations associated with the X-linked CGD carrier state. Read More

    Identification of candidate genes for paratuberculosis resistance in the native Italian Garfagnina goat breed.
    Trop Anim Health Prod 2017 May 19. Epub 2017 May 19.
    Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, Pisa, Italy.
    Paratuberculosis disease is a chronic bacterial disease infection of ruminants of global relevance, caused by MAP (Mycobacterium avium subsp. paratuberculosis). The present study was conducted on the Garfagnina goat breed that is an Italian native goat population registered on the Tuscan regional repertory of genetic resources at risk of extinction. Read More

    Life-Threatening Hypercalcemia During Prodrome of Pneumocystis jiroveci Pneumonia in an Immunocompetent Infant.
    Glob Pediatr Health 2017 2;4:2333794X17705955. Epub 2017 May 2.
    Children's Mercy Hospital, University of Missouri at Kansas City, MO, USA.
    Severe hypercalcemia in infants is usually attributed to genetic etiologies and less commonly to acquired ones. An 8-week-old girl presented with failure to thrive, mild respiratory distress, and life-threatening hypercalcemia (23.5 mg/dL). Read More

    IBD due to PID: Inflammatory bowel disease caused by primary immunodeficiencies - Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm.
    Pediatr Allergy Immunol 2017 May 17. Epub 2017 May 17.
    Centre for Paediatrics, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a multifactorial pathogenesis with complex interactions between polygenetic predispositions and environmental factors. However, IBD can also be caused by monogenic diseases, such as primary immunodeficiencies (PID). Recently, an increasing number of these altogether rare diseases has been described to present often primarily, or solely as IBD. Read More

    Sarcoidosis in Israel: Clinical Outcome Status, Organ Involvement, and Long-Term Follow-Up.
    Lung 2017 May 15. Epub 2017 May 15.
    Pulmonary Department, Meir Medical Center, Tshernichovsky 59, 442801, Kfar Saba, Israel.
    Purpose: Sarcoidosis is a chronic granulomatous inflammatory disease of unknown etiology with heterogeneous outcomes. This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five-year period. Further, we compared our results to the 'World Association of Sarcoidosis and Other Granulomatous Disease' (WASOG) COS and the 'A Case Control Etiologic Study of Sarcoidosis' (ACCESS) instruments in order to evaluate their relevance to the Israeli population. Read More

    Silicone Injection-Related Granulomatous Hypercalcemia.
    Am J Med Sci 2017 May 29;353(5):492-494. Epub 2016 Apr 29.
    Division of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, Virginia. Electronic address:
    Cosmetic filler injections are known to cause a number of acute and chronic effects, including local inflammation, nodule formation and granulomatous reaction. The timeline of these events is highly variable, occurring from hours to decades following injection. In few cases, systemic effects have been observed. Read More

    Acremonium pneumonia in an AIDS patient.
    IDCases 2017 25;8:75-76. Epub 2017 Apr 25.
    Hofstra Northwell School of Medicine, United States.
    Acremonium is a saprophytic fungus mostly causing superficial skin, nail, or ocular infections after traumatic inoculation. However, it is being recently recognized as one of the opportunistic infections in immunocompromised patients including neutropenia, malignancies, chronic granulomatous disease (CGD) and transplant recipients. To our knowledge there have been no reported cases of Acremonium infection, related to HIV or AIDS. Read More

    Haploinsufficiency of NADPH oxidase subunit NCF2 is sufficient to accelerate full-blown lupus in NZM.2328 mice.
    Arthritis Rheumatol 2017 May 4. Epub 2017 May 4.
    Washington University School of Medicine in St Louis, St Louis, Missouri, 63110.
    Objective: We have previously established that NCF2 (Neutrophil cytosolic factor 2) is a lupus predisposing gene and identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. This study was undertaken to investigate the relationship between reduced leukocyte NADPH oxidase activity and immune dysregulation associated with SLE.

    Methods: We generated NCF2-null mice, in which NADPH oxidase activity is absent, on the non-autoimmune C57BL/6 background and on the NZM. Read More

    Cervicofacial Primary Cutaneous Actinomycosis: Surgical Treatment for Complete Remission of the Disease.
    J Craniofac Surg 2017 May;28(3):e269-e271
    Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Actinomycosis, an infectious bacterial disease caused by Actinomyces species, is very rare and is characterized by contiguous spreading, subacute to chronic granulomatous inflammation and the formation of multiple abscesses and sinus tracts that may discharge sulfur granules. Actinomycosis that presents on the skin without endogenous origin is called primary cutaneous actinomycosis, and the occurrence and treatment of primary cutaneous actinomycosis is rarely reported. This report describes the treatment of primary cervicofacial actinomycosis with a literature review, and emphasizes the importance of surgical option for complete remission of the disease. Read More

    Hepatic Capillariasis - Drug Targets.
    Infect Disord Drug Targets 2017 Apr 27. Epub 2017 Apr 27.
    Seth GSMC and KEM Hospital Mumbai. India.
    Zoonotic infections are increasingly becoming public health menaces and are usually transmitted to humans due to unsuitable environmental conditions. One of them is hepatic capillariasis, caused by the parasite Capillaria hepatica, primarily a disease of rodents, with hepatic manifestations in humans. Although its prevalence is very low, it can cause significant morbidity and mortality, with cases reported from all over the world. Read More

    Lepromatous leprosy in a renal transplant recipient.
    Am J Transplant 2017 Apr 27. Epub 2017 Apr 27.
    Department of Nephrology, Haydarpaşa Numune Training and Research Hospital, İstanbul.
    Leprosy is a chronic granulomatous disease caused by acid fast bacillus Mycobacterium Leprae. It is rare in organ transplant patients; cases have been reported in three heart, one liver, and 12 renal transplantation patients in Worldwide (1,2). We report on a patient with lepromatous leprosy presenting six years after renal transplantation. Read More

    Lupus miliaris disseminatus faciei: A resistant case with response to cyclosporine.
    Dermatol Ther 2017 Apr 26. Epub 2017 Apr 26.
    Lok Nayak Hospital, Address, 107 Cruikshank Street, Frenchville, Rockhampton, QLD 4701, Australia.
    Lupus miliaris disseminatus faciei (LMDF) is a chronic, inflammatory dermatosis of unknown etiology, characterized by multiple, monomorphic, symmetrical, reddish-brown papules over forehead, cheeks, and eyelids. Histopathology shows perifollicular epitheloid cell granuloma. Though numerous therapies, ranging from cyclines, macrolides, dapsone tranilast, isotretinoin, steroids, and tacrolimus have been tried, the results are inconsistent, except with systemic steroids. Read More

    Successful hepatectomy for hepatic abscess with chronic granulomatous disease: a case report.
    Surg Case Rep 2017 Dec 26;3(1):57. Epub 2017 Apr 26.
    Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, Gunma University, 3-39-33, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
    Background: Chronic granulomatous disease (CGD), a rare inherited disorder, is characterized by impaired ability of phagocytic cells to kill certain bacteria and fungi. Although liver abscess is a common manifestation of CGD, its optimal management in these patients is unknown. Here, we present a case of successful hepatectomy for hepatic abscess in a patient with CGD. Read More

    Fungal Rhinosinusitis: A Radiological Review With Intraoperative Correlation.
    Can Assoc Radiol J 2017 May;68(2):178-186
    Neuroradiology, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada.
    The interaction between fungi and the sinonasal tract results in a range of clinical presentations with a broad spectrum of clinical severity. The most commonly accepted classification system divides fungal rhinosinusitis into invasive and noninvasive subtypes based on histopathological evidence of tissue invasion by fungi. Invasive fungal rhinosinusitis is subdivided into acute invasive and chronic invasive categories. Read More

    Paecilomyces formosus Infection in an Adult Patient with Undiagnosed Chronic Granulomatous Disease.
    J Clin Immunol 2017 May 20;37(4):342-346. Epub 2017 Apr 20.
    Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    Rhinoscleroma: a chronic infectious disease of poor areas with characteristic histological features - report of a series of six cases.
    Trop Doct 2017 Jan 1:49475517704612. Epub 2017 Jan 1.
    1 Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Rhinoscleroma is a chronic infectious disease that is endemic in certain poor areas of the world. The diagnosis often relies on pathology, the outcome is disappointing and then marked by recurrence. We present a retrospective series of six patients histologically diagnosed with rhinoscleroma. Read More

    mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France.
    Emerg Infect Dis 2017 May;23(5):874-876
    We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance. Read More

    [Clinical features, risk factors and progresses on treatment of recurrent Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Apr;53(4):317-320
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Vogt-Koyanagi-Harada disease(VKH) is a bilateral, granulomatous panuveitis associated with central nervous system, auditory, and integumentary manifestations. Clinically, VKH usually responds well to early aggressive glucocorticosteroid treatment and may be cured without any clinically significant sequelae. Some patients, however, may enter the chronic recurrent phase, which may result in marked loss of vision due to complications such as complicated cataract, secondary glaucoma and maculopathy. Read More

    Anti-inflammatory and membrane stabilizing properties of methyl jasmonate in rats.
    Chin J Nat Med 2017 Mar;15(3):202-209
    Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences University of Ibadan, Ibadan, Nigeria.
    The present investigation was carried out to evaluate anti-inflammatory and membrane stabilizing properties of methyl jasmonate (MJ) in experimental rat models of acute and chronic inflammation. The effects of MJ on acute inflammation were assessed using carrageenan-induced rat's paw edema model. The granuloma air pouch model was employed to evaluate the effects of MJ on chronic inflammation produced by carrageenan in rats. Read More

    Brain-eating amoebae: Predilection sites in the brain and disease outcome.
    J Clin Microbiol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Biological Sciences, School of Science and Technology, Sunway University, Malaysia.
    Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection lasting few days, while GAE is a chronic to subacute infection that can last up to several months. Read More

    Nontuberculous mycobacterial infection of the musculoskeletal system in immunocompetent hosts.
    Indian J Orthop 2017 Mar-Apr;51(2):205-212
    Department of Pathology, Hinduja Hospital and Medical Research Center, Mumbai, Maharashtra, India.
    Background: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. Read More

    Single-centre experience of granulomatous interstitial nephritis-time for a new approach?
    Clin Kidney J 2017 Apr 7;10(2):249-254. Epub 2017 Jan 7.
    Renal Unit, King's College Hospital, London, UK.
    Background: Differentiating between renal-limited sarcoidosis and tuberculosis (TB) infection as a cause of granulomatous interstitial nephritis (GIN) can be difficult. This series compares clinical features and response to treatment between the different underlying aetiologies in order to propose a management algorithm for GIN to assist with diagnosis and treatment. Methods: This retrospective study reports on all patients presenting with a histological diagnosis of GIN between 2000 and 2012 at our unit. Read More

    Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma.
    J Ocul Pharmacol Ther 2017 May 10;33(4):325-333. Epub 2017 Apr 10.
    1 F.I. Proctor Foundation, University of California , San Francisco, San Francisco, California.
    Necrobiotic xanthogranuloma (NXG) is a chronic, progressive non-Langerhans histiocytic granulomatous disease. While case reports describing periorbital involvement of NXG are frequent, only a few case reports describing ocular involvement, such as scleritis and uveitis, exist. Herein, we present a case presenting initially as bilateral anterior and posterior scleritis, as well as a chronic bilateral granulomatous panuveitis, and discuss the immunosuppressant options that should be considered for this disease with protean manifestations. Read More

    Clinical Implications for the Timely Diagnosis of Mycobacterium marinum in the Age of Biologic Therapy: A Case Report and Review of the Literature.
    Case Rep Infect Dis 2017 14;2017:5274302. Epub 2017 Mar 14.
    Division of Infectious Diseases, Department of Internal Medicine, University of Calgary, Calgary, AB, Canada.
    Mycobacterium marinum infections typically present as cutaneous nodular lesions with a sporotrichoid lymphatic spread on extensor surfaces of extremities. The natural history of this infection can be altered if the host is immunosuppressed, leading to disseminated presentations. A detailed exposure history and high degree of suspicion for this indolent pathogen are often required for the correct diagnosis of this disease. Read More

    Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab.
    ACG Case Rep J 2017 29;4:e46. Epub 2017 Mar 29.
    Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal.
    Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. Read More

    Mycobacterium avium subsp. paratuberculosis (Map) Fatty Acids Profile Is Strain-Dependent and Changes Upon Host Macrophages Infection.
    Front Cell Infect Microbiol 2017 21;7:89. Epub 2017 Mar 21.
    Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Technological Park of BizkaiaDerio, Spain; Servicio Regional de Investigación y Desarrollo Agroalimentario, Agri-Food Research and Development Regional ServiceVillaviciosa, Spain.
    Johne's disease is a chronic granulomatous enteritis of ruminants caused by the intracellular bacterium Mycobacterium avium subsp. paratuberculosis (Map). We previously demonstrated that Map isolates from sheep persisted within host macrophages in lower CFUs than cattle isolates after 7 days of infection. Read More

    Chronic Granulomatous Disease Presenting as Aspergillus Fumigatus Pneumonia in a Previously Healthy Young Woman.
    Am J Case Rep 2017 Apr 5;18:351-354. Epub 2017 Apr 5.
    Department of Infectious Disease, Baptist Memorial Health Care, Memphis, TN, USA.
    BACKGROUND Chronic Granulomatous Disease (CGD) is a rare immunodeficiency disease caused by a genetic defect in the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase enzyme, resulting in increased susceptibility to bacterial and fungal infections. The inheritance can be X-linked or autosomal recessive. Patients usually present with repeated infections early in life. Read More

    Chronic Granulomatous Disease in Patients Reaching Adulthood: A Nationwide Study in France.
    Clin Infect Dis 2017 Mar;64(6):767-775
    Service de Maladies Infectieuses et Tropicales, Centre d''Infectiologie Necker Pasteur, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris.
    Background: Although prognosis of Chronic Granulomatous Disease (CGD) has greatly improved, few studies have focused on its long-term outcome. We studied the clinical course and sequelae of CGD patients diagnosed before age 16, at various adult time points.

    Method: Cross-sectional French nationwide retrospective study of patients screened through the National Reference Center for Primary Immunodeficiencies (CEREDIH) registry. Read More

    Therapeutic effects of proteoliposomes on X-linked chronic granulomatous disease: proof of concept using macrophages differentiated from patient-specific induced pluripotent stem cells.
    Int J Nanomedicine 2017 20;12:2161-2177. Epub 2017 Mar 20.
    UMR CNRS 5525, University of Grenoble Alpes, Grenoble, France; CGD Diagnosis and Research Centre, University Hospital Centre of Grenoble Alpes, Grenoble, France.
    Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency due to dysfunction of the phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex leading to severe and recurrent infections in early childhood. The main genetic form is the X-linked CGD leading to the absence of cytochrome b558 composed of NOX2 and p22 (phox) , the membrane partners of the NADPH oxidase complex. The first cause of death of CGD patients is pulmonary infections. Read More

    Serological, culture and molecular survey of Mycobacterium avium paratuberculosis in a goat flock in Tuscany.
    Folia Microbiol (Praha) 2017 Mar 28. Epub 2017 Mar 28.
    Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, Pisa, Italy.
    Mycobacterium avium paratuberculosis (Map) is a pathogen which causes a chronic progressive granulomatous enteritis known as paratuberculosis or Johne's disease and it primarily affects wild and domestic ruminants. The aim of this research was to examine a flock which consisted of 294 goats and was located in Garfagnana district (Tuscany, Italy) performing ELISA tests, culture and IS900 PCR assay; direct diagnostic methods were carried out not only on bulk tank milk and cheese samples but also on individual milk and tissue specimens collected from nine subjects positive to ELISA tests. Out of 294 animals, 20 goats (6. Read More

    Chromobacterium violaceum infection in chronic granulomatous disease: a case report and review of the literature.
    JMM Case Rep 2017 Jan 31;4(1):e005084. Epub 2017 Jan 31.
    Department of Infectious Diseases, Austin Health, Heidelberg, VIC 3084, Australia; Department of Microbiology, Austin Health, Heidelberg, VIC 3084, Australia.
    Introduction.Chromobacterium violaceum is an opportunistic human pathogen, associated with significant mortality, and has been reported in patients with chronic granulomatous disease (CGD), a genetic condition causing impaired phagocytosis. Case presentation. Read More

    Inflammatory and autoimmune manifestations in X-linked carriers of chronic granulomatous disease in the United Kingdom.
    J Allergy Clin Immunol 2017 Mar 23. Epub 2017 Mar 23.
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Paediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

    Granulocyte transfusions in patients with chronic granulomatous disease and refractory infections: The NIH experience.
    J Allergy Clin Immunol 2017 Mar 22. Epub 2017 Mar 22.
    Immunology Service, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md; Primary Immunodeficiency Clinic, NIAID, National Institutes of Health, Bethesda, Md. Electronic address:

    Severe Aspergillus Pneumonia and Pulmonary Artery Hypertension in a Child with Autosomal Recessive Chronic Granulomatous Disease and Selective IgA Deficiency.
    J Clin Immunol 2017 May 24;37(4):333-335. Epub 2017 Mar 24.
    Allergy Immunology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

    Chronic granulomatous disease caused by maternal uniparental isodisomy of chromosome 16.
    J Allergy Clin Immunol Pract 2017 Mar 21. Epub 2017 Mar 21.
    Department of Immunology, La Paz University Hospital, Madrid, Spain; Lymphocyte Pathophysiology Group, La Paz Institute of Biomedical Research, IdiPAZ, Madrid, Spain.

    Disseminated Lichtheimia ramosa Infection After Hematopoietic Stem Cell Transplantation in a Child with Chronic Granulomatous Disease.
    Pediatr Infect Dis J 2017 Mar 22. Epub 2017 Mar 22.
    1.Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 2.Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Mucormycosis is uncommon in patients with chronic granulomatous disease (CGD). We report a 7-year-old boy with X-linked CGD and absent oxidative burst who developed fatal Lichtheimia ramosa infection with fungal thrombosis of the kidneys, spleen, and other organs following hematopoietic stem cell transplantation (HSCT). Lichtheimia infection is rarely reported in patients with CGD and could be related to iatrogenic immunosuppression. Read More

    Infection Profile in Chronic Granulomatous Disease: a 23-Year Experience from a Tertiary Care Center in North India.
    J Clin Immunol 2017 Apr 22;37(3):319-328. Epub 2017 Mar 22.
    Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigargh, 160012, India.
    Purpose: Chronic granulomatous disease (CGD) is an inherited phagocytic disorder characterized by recurrent infections with usually catalase-positive organisms. Infections in CGD from developing countries are expected to be different from those in the Western countries. We report the profile of infections in children diagnosed with CGD from a tertiary care center in North India. Read More

    Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model.
    Clin Vaccine Immunol 2017 May 5;24(5). Epub 2017 May 5.
    Center of Integrative Microbial Evolution and Department of Pharmaceutical Biosciences, School of Pharmacy, Faculty of Mathematics and Natural Science, University of Oslo, Oslo, Norway
    Vaccine development against extracellular bacteria has been important for the sustainability of the aquaculture industry. In contrast, infections with intracellular pathogens remain largely an unresolved problem. Francisella noatunensis subsp. Read More

    [Actinomycosis Involving Chronic Pancreatitis: A Case Report with Literature Review].
    Korean J Gastroenterol 2017 Mar;69(3):191-195
    Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
    Actinomycosis is a slowly progressive, chronic infectious disease. It is caused by the genus Actinomyces, which are gram-positive anaerobic bacteria. It presents as a mass-like lesion, composed of bacterial nidus and characteristic granulomatous inflammatory fibrosis. Read More

    Chronic granulomatous disease as a risk factor for cutaneous lupus in childhood.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Dermatology, Centro Hospitalar do Porto, Oporto, Portugal.
    Chronic granulomatous disease (CGD) is a primaryimmunodeficiency disorder that affects the phagocyticcells of the innate immune system. It is characterizedby recurrent or persistent infections with granulomaformation. Lupus-like lesions have been reported incarriers of CGD and less frequently, in patients withCGD. Read More

    Borderline Tuberculoid Leprosy Masquerading as Granuloma Annulare: A Clinical and Histological Pitfall.
    Am J Dermatopathol 2017 Apr;39(4):296-299
    *Keck School of Medicine, University of Southern California, Los Angeles, CA; andDepartments of †Dermatology, and‡Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA.
    Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae, an intracellular acid-fast bacillus that tends to infect the skin and peripheral nerves. Because of the wide array of cutaneous manifestation, diagnosis is not always straightforward, especially in nonendemic regions of the world such as the United States.

    Case Report: The authors report an unusual case of borderline tuberculoid leprosy in an 80-year-old white woman from California. Read More

    Co-morbidities in severe asthma: Clinical impact and management.
    Respirology 2017 May 22;22(4):651-661. Epub 2017 Mar 22.
    Royal Brompton and Harefield NHS Foundation Trust, London, UK.
    Patients with severe asthma represent a minority of the total asthma population, but carry a majority of the morbidity and healthcare costs. Achieving better asthma control in this group of patients is therefore of key importance. Systematic assessment of patients with possible severe asthma to identify treatment barriers and triggers of asthma symptoms, including co-morbidities, improves asthma control and reduces healthcare costs and is recommended by international guidelines on management of severe asthma. Read More

    Pituitary Adenoma and Hyperprolactinemia Accompanied by Idiopathic Granulomatous Mastitis.
    Case Rep Endocrinol 2017 22;2017:3974291. Epub 2017 Feb 22.
    General Surgery Department, Liv Hospital, Ulus, Istanbul, Turkey.
    Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of the breast, and its etiology remains not fully elucidated. IGM is observed more often in patients with autoimmune disease. Hyperprolactinemia is observed during pregnancy, lactation, and a history of oral contraceptive use. Read More

    Early intracellular trafficking of Granulibacter bethesdensis in human macrophages.
    Infect Immun 2017 Mar 20. Epub 2017 Mar 20.
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Granulibacter bethesdensis is a Gram-negative bacterium that infects patients with Chronic Granulomatous Disease (CGD), a primary immunodeficiency marked by a defect in NOX2, the phagocyte nicotinamide adenine dinucleotide phosphate oxidase. Previous studies have shown that NOX2 is essential for killing of G. bethesdensis by neutrophils and monocytes and that bacteriostatic activity of monocyte derived macrophages (MDM) requires NOX2 and IFNγ-pretreatment. Read More

    [Serratia infections, should we think about primary immunodeficiencies?]
    Arch Argent Pediatr 2017 Apr;115(2):e108-e111
    Hospital Infantil Miguel Servet, Zaragoza, España.
    Chronic granulomatous disease (CGD) is a primary immunodeficiency with an incidence of 1/200,000-250,000 live births. CGD affects mainly male patients, most of the mutations being X-linked, and autosomal recessive forms occur more frequently in communities with greater numbers of consanguineous marriages. CGD is characterized by sensitivity to recurrent and severe bacterial and fungal infections, with formation of granulomas due to the inability of phagocytes to generate reactive oxygen compounds, necessary for the intracellular death of phagocytic microorganisms. Read More

    An oral lesion as the primary clinical manifestation of sarcoidosis.
    Ann R Coll Surg Engl 2017 May 16;99(5):e135-e136. Epub 2017 Mar 16.
    Mid Essex Hospital Services NHS Trust , UK.
    An oral lesion as the first clinical presentation of sarcoidosis is extremely rare. We present the case of a 39-year-old woman who was referred to the oral and maxillofacial surgery department with a persistent asymptomatic nodular lesion in the hard palate. This was located adjacent to a grossly carious upper first molar and a provisional diagnosis of chronic periapical granuloma was made. Read More

    Cutaneous Crohn's disease with superimposed psoriasis: A unique case with overlapping histology.
    J Cutan Pathol 2017 Jun 17;44(6):588-590. Epub 2017 Apr 17.
    Department of Dermatology & Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Crohn's disease (CD) is an idiopathic, chronic inflammatory disorder of the gastrointestinal tract. We recently encountered a unique case in which a patient with longstanding CD presented with skin lesions with histopathologic features of both psoriasis and granulomatous inflammation suggestive of cutaneous CD. To our knowledge, this has not been described concomitantly in the same patient, in the same lesions. Read More

    Diagnostic Tools for Doctors' Evaluation of Tattoo Complications.
    Curr Probl Dermatol 2017 13;52:42-57. Epub 2017 Mar 13.
    The 'Tattoo Clinic', Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.
    Diagnosis of tattoo complications is a multi-facetted field since many clinical entities and disease mechanisms are represented. Infections, allergies, and pigment foreign body reactions with granuloma are the major groups. The clinician needs a structured approach to diagnosis and an armamentarium of standard tests. Read More

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