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    6840 results match your criteria Chronic Granulomatous Disease

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    Immunomodulatory properties of Concholepas concholepas hemocyanin against francisellosis in a zebrafish model.
    Fish Shellfish Immunol 2017 Jun 17. Epub 2017 Jun 17.
    Center of Integrative Microbial Evolution, Department of Pharmaceutical Biosciences, School of Pharmacy, Faculty of Mathematics and Natural Science, University of Oslo, Norway.
    The development of vaccines for aquaculture has been an important milestone in providing a continuous and sustainable production. Most of the vaccines currently on the market for aquaculture include oil as adjuvant. Nevertheless, several studies reported an occurrence of side effects after their use in farmed fish. Read More

    Mediastinal hemangioendothelioma: Case report and review of the literature.
    Respir Med Case Rep 2017 3;22:19-23. Epub 2017 Jun 3.
    Department of Thoracic Surgery, University College London Hospitals (UCLH), London, UK.
    Background: Epithelioid haemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that can arise in the lung, liver, soft tissues or, less commonly, bone. Due to its low prevalence of less than one in a million and its non-specific clinical features, EHE is often misdiagnosed and managed inappropriately. Here we discuss the case of a 58 year-old gentleman with mediastinal EHE and review existing literature on pulmonary EHE (PEH). Read More

    Analysis of sarcoidosis in the Oporto region (Portugal).
    Rev Port Pneumol (2006) 2017 Jun 15. Epub 2017 Jun 15.
    Pneumology Department and Diffuse Lung Disease Study Group, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine of Porto University, Porto, Portugal.
    Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Epidemiological studies of different populations are essential because clinical presentation, organ involvement, disease severity, and prognosis vary significantly according to region and population. The aim of this study was to assess epidemiological and clinical characteristics, staging factors, and clinical course in patients with sarcoidosis from a tertiary hospital in Oporto, Portugal. Read More

    Tuberculosis masked by immunodeficiency: a review of two cases diagnosed with chronic granulomatous disease.
    Tuberk Toraks 2017 Mar;65(1):56-59
    Clinic of Pediatric Immunology and Allergy, Dr. Behçet Uz Children Diseases Training and Research Hospital, Izmir, Turkey.
    Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency that is characterized by recurrent and life-threatening infections resulting from defects in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and granuloma formation due to increased inflammatory response. The most commonly involved organs are the lungs, skin, lymph nodes, and liver due to infection. It may present with recurrent pneumonia, hilar lymphadenopathy, empyema, abscess, reticulonodular patterns, and granulomas due to lung involvement. Read More

    Brain changes detected by functional magnetic resonance imaging and spectroscopy in patients with Crohn's disease.
    World J Gastroenterol 2017 May;23(20):3607-3614
    Kun Lv, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China.
    Crohn's disease (CD) is a chronic, non-specific granulomatous inflammatory disorder that commonly affects the small intestine and is a phenotype of inflammatory bowel disease (IBD). CD is prone to relapse, and its incidence displays a persistent increase in developing countries. However, the pathogenesis of CD is poorly understood, with some studies emphasizing the link between CD and the intestinal microbiota. Read More

    Bilateral ocular ischemia-induced blindness as a presenting manifestation of Takayasu arteritis: a case report.
    J Med Case Rep 2017 Jun 10;11(1):153. Epub 2017 Jun 10.
    Department of Cardiovascular Medicine, Jakaya Kikwete Cardiac Institute, P.O. Box 65141, Dar es Salaam, Tanzania.
    Background: Takayasu arteritis is a granulomatous panarteritis that predominantly affects the aorta and its major branches. The initial manifestations of this large-vessel vasculitis are usually nonspecific; however, as the disease progresses, typical symptoms of arterial occlusion, aneurysmal formation, and vascular pain become evident. Ischemic ocular complications of Takayasu arteritis which could lead to complete loss of vision are not uncommon and depend on the obliterated portion(s) of carotid(s), the intensity and rate of progression of ocular vascular insufficiency, and sufficiency of the collateral blood supply to the eye. Read More

    Pathology of Tuberculosis: How the Pathology of Human Tuberculosis Informs and Directs Animal Models.
    Microbiol Spectr 2017 Jun;5(3)
    Department of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
    Tuberculosis (TB) is a chronic inflammatory disease caused by the pathogenic bacterium Mycobacterium tuberculosis. A wide variety of host- and pathogen-associated variables influence the clinical manifestation of TB in different individuals within the human population. As a consequence, the characteristic granulomatous lesions that develop within the lung are heterogeneous in size and cellular composition. Read More

    Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review.
    J Pathol Transl Med 2017 Jun 5. Epub 2017 Jun 5.
    Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. However, some rare gastric lesions exhibiting distinctive histological features may also be associated with H. pylori infection, including lymphocytic gastritis, granulomatous gastritis, Russell body gastritis, or crystal-storing histiocytosis. Read More

    [Vogt-Koyanagi-Harada disease].
    J Fr Ophtalmol 2017 Jun 1;40(6):512-519. Epub 2017 Jun 1.
    Université Paris Descartes, 75014 Paris, France; Centre Cochin ambulatoire d'ophtalmologie, groupe hospitalier Cochin-Hôtel-Dieu, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
    Vogt-Koyanagi-Harada (VKH) disease is defined as a severe bilateral, chronic granulomatous panuveitis associated with serous retinal detachments, disk edema, and vitritis, with central nervous system, auditory, and integumentary manifestations. It is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals genetically susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, acute inflammatory, chronic, and recurrent, with extraocular manifestations including headache, meningitis, hearing loss, poliosis, and vitiligo. Read More

    Seven chronic granulomatous disease cases in a single-center experience and a review of the literature.
    Asian Pac J Allergy Immunol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Pediatrics, Division of Immunology and Allergy, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
    Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme system. This disease causes the disordered functioning of phagocytic cells. It is characterized by life-threatening and/or recurrent infections by bacteria and fungi. Read More

    Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC.
    Redox Biol 2017 Apr 24;13:82-93. Epub 2017 Apr 24.
    Department of Pathology and Immunology, University of Geneva Medical School, 1-rue Michel Servet, 1211 Geneva, Switzerland. Electronic address:
    There is emerging evidence for the involvement of reactive oxygen species (ROS) in the regulation of stem cells and cellular differentiation. Absence of the ROS-generating NADPH oxidase NOX2 in chronic granulomatous disease (CGD) patients, predominantly manifests as immune deficiency, but has also been associated with decreased cognition. Here, we investigate the role of NOX enzymes in neuronal homeostasis in adult mouse brain and in neural cells derived from human induced pluripotent stem cells (iPSC). Read More

    Diverse stimuli engage different neutrophil extracellular trap pathways.
    Elife 2017 Jun 2;6. Epub 2017 Jun 2.
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.
    Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans and Group B Streptococcus. We studied NET production in neutrophils from healthy donors with inhibitors of molecules crucial to PMA induced NETs including protein kinase C, calcium, reactive oxygen species, the enzymes myeloperoxidase (MPO) and neutrophil elastase. Read More

    Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention.
    World J Gastrointest Pathophysiol 2017 May;8(2):87-92
    Daniel Kotlarz, Jacek Puchalka, Cristoph Klein, Department of Pediatrics Dr. Von Hauner Children's Hospital, Ludwig-Maximilians-University, 80539 Munich, Germany.
    Chronic granulomatous disease (CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years (95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease (IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis (UC) and end up having a colectomy. Read More

    Leprosy in an Eight-Year-Old Child - An Exceptional Case with Unusual Oral Manifestation.
    J Clin Diagn Res 2017 Apr 1;11(4):ZD19-ZD20. Epub 2017 Apr 1.
    Senior Lecturer, Department of Oral Medicine and Radiology, Maharana Pratap College of Dentistry and Research Centre, Gwalior, Madhya Pradesh, India.
    Leprosy is a contagious and granulomatous disease which is caused by Mycobacterium leprae. The incubation period for leprosy is five to seven years and it can take as long as about 30 years before signs and symptoms of leprosy develop in some patients. It is a chronic systemic disease which mostly affects the skin and peripheral nerves. Read More

    Serum enolase-2, high-sensitivity C-reactive protein, and serum cholesterol in smear-positive drug-naïve pulmonary tuberculosis.
    J Res Med Sci 2017 26;22:49. Epub 2017 Apr 26.
    Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
    Background: Pulmonary tuberculosis (PTB) is a chronic granulomatous disease caused by Mycobacterium tuberculosis. The present study determined the serum human enolase-2 (ENO-2), high-sensitive C-reactive protein (hs-CRP), and serum cholesterol levels as biological marker of disease activity and treatment response in smear-positive drug-naïve PTB.

    Materials And Methods: This case-control study was done in the Department of Medicine, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro/Hyderabad, Sindh, from January 2015 to April 2016. Read More

    A contemporary analysis of clinical and demographic factors of chronic rhinosinusitis patients and their association with disease severity.
    Ir J Med Sci 2017 May 30. Epub 2017 May 30.
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, 02114, USA.
    Background: Chronic rhinosinusitis (CRS) is highly prevalent, significantly decreases quality of life and leads to tremendous health care costs every year. No recent study has characterised the prevalence of potentially CRS-modifying patient characteristics and simultaneously shown their impact on CRS severity.

    Aims: We sought to determine the prevalence of potential clinical and demographic CRS-modifying characteristics and their associations with CRS symptom severity in a large contemporary cohort of CRS patients. Read More

    Laparoscopic Intervention in Acute Crohn's Disease Involving an Ovary.
    J Minim Invasive Gynecol 2017 May 27. Epub 2017 May 27.
    Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland; Ludwin and Ludwin Gynecology, Krakow, Poland. Electronic address:
    Crohn's disease (CD) is a chronic inflammatory disorder that may involve any part of the gastrointestinal tract. Acute manifestations in female internal reproductive organs are rare and have been described in only a few cases. A 27-year-old nulligravida diagnosed with CD presented with pelvic pain, fever, and a palpable mass (confirmed by ultrasound) in the right lower quadrant of the abdomen. Read More

    Age predicts cytokine kinetics and innate immune cell activation following intranasal delivery of IFNγ and GM-CSF in a mouse model of RSV infection.
    Cytokine 2017 May 27;97:25-37. Epub 2017 May 27.
    Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA, USA; Center for Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
    Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in young children and is further associated with increased healthcare utilization and cost of care in the first years of life. Severe RSV disease during infancy has also been linked to the later development of allergic asthma, yet there remains no licensed RSV vaccine or effective treatment. Pre-clinical and clinical studies have shown that disease severity and development of allergic asthma are associated with differences in cytokine production. Read More

    Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease.
    Front Immunol 2017 11;8:543. Epub 2017 May 11.
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
    Chronic granulomatous disease (CGD) results from primary defects in phagocytic reactive oxygen species (ROS) production. T-cell evaluation is usually neglected during patients' follow-up, although T-cell depletion has been reported in CGD through unknown mechanisms. We describe here a 36-year-old patient with X-linked CGD with severe CD4 T-cell depletion <200 CD4 T-cells/μl, providing insights into the mechanisms that underlie T-cell loss in the context of oxidative burst defects. Read More

    Algorithms for imputing partially observed recurrent events with applications to multiple imputation in pattern mixture models.
    J Biopharm Stat 2017 May 25. Epub 2017 May 25.
    a 300 Shire Way , Lexington , MA.
    Five algorithms are described for imputing partially observed recurrent events modeled by a negative binomial process, or more generally by a mixed Poisson process when the mean function for the recurrent events is continuous over time. We also discuss how to perform the imputation when the mean function of the event process has jump discontinuities. The validity of these algorithms is assessed by simulations. Read More

    Analysis of the patients with simultaneous bilateral spontaneous pneumothorax.
    Clin Respir J 2017 May 20. Epub 2017 May 20.
    School of Medicine, Department of Thoracic Surgery, Ege University, Izmir, Turkey.
    Background: Simultaneous bilateral spontaneous pneumothorax (SBSP) is an uncommon condition with limited data on its incidence in the literature. In this study, we aimed to describe the bilaterality in both primary and secondary spontaneous pneumothorax cases, and the clinical approach in simultaneous disease and prognosis of these patients.

    Methods: A total of 16 patients who were followed with the diagnosis of bilateral spontaneous pneumothorax between January 2005 and January 2017 were retrospectively analyzed. Read More

    Chronic paracoccidioidmycosis in a woman with Crohn Disease.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Department of Diagnosis and Surgery, Araraquara Dental School, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
    We report a rare case of chronic paracoccidioidomycosis(PCM) in a woman with Crohn disease in the setting of treatment with azathioprine and mesalazine. Serum tests for antigens to Paracoccidioides brasiliensis, Histoplasma capsulatum, and Aspergillus fumigatus were negative. An incisional biopsy of an oral lesion with periodic acid-schiff and Grocott-methenamine silver stains revealed chronic granulomatous inflammation with multinucleated giant cells with Paracoccidioides brasiliensis within the cytoplasm, confirming the diagnosis of PCM. Read More

    Lipopolysaccharide-induced acute lung injury in mice chronically infected by Schistosoma mansoni.
    Exp Parasitol 2017 Jul 19;178:21-29. Epub 2017 May 19.
    Institute of Biomedical Sciences, Department of Pathology and Parasitology, Federal University of Alfenas, Minas Gerais, 37130-001, Brazil. Electronic address:
    We used a murine model of Schistosoma mansoni (SM) infection and lipopolysaccharide (LPS)-induced endotoxicity to investigate if these conditions can interact to modify the pathological manifestations typically observed in each condition. Swiss mice were randomized into four groups: SAL, uninfected; SM, infected; LPS, uninfected + LPS; and SM + LPS, infected + LPS. S. Read More

    Johne's disease in the eyes of Irish cattle farmers: A qualitative narrative research approach to understanding implications for disease management.
    Prev Vet Med 2017 Jun 8;141:7-13. Epub 2017 Apr 8.
    School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
    Bovine Johne's Disease (JD) is a disease characterised by chronic granulomatous enteritis which manifests clinically as a protein-losing enteropathy causing diarrhoea, hypoproteinaemia, emaciation and, eventually death. Some research exists to suggest that the aetiologic pathogen Mycobacterium avium subspecies paratuberculosis may pose a zoonotic risk. Nationally coordinated control programmes have been introduced in many of the major milk producing countries across the world. Read More

    X-linked Carriers of Chronic Granulomatous Disease: Illness, Lyonization and Stability.
    J Allergy Clin Immunol 2017 May 17. Epub 2017 May 17.
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH. Electronic address:
    Background: Chronic granulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and aberrant inflammation. Mutations in CYBB cause X-linked CGD and account for 65%-70% of cases in western countries.

    Objective: To understand the clinical manifestations associated with the X-linked CGD carrier state. Read More

    Identification of candidate genes for paratuberculosis resistance in the native Italian Garfagnina goat breed.
    Trop Anim Health Prod 2017 May 19. Epub 2017 May 19.
    Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, Pisa, Italy.
    Paratuberculosis disease is a chronic bacterial disease infection of ruminants of global relevance, caused by MAP (Mycobacterium avium subsp. paratuberculosis). The present study was conducted on the Garfagnina goat breed that is an Italian native goat population registered on the Tuscan regional repertory of genetic resources at risk of extinction. Read More

    Life-Threatening Hypercalcemia During Prodrome of Pneumocystis jiroveci Pneumonia in an Immunocompetent Infant.
    Glob Pediatr Health 2017 2;4:2333794X17705955. Epub 2017 May 2.
    Children's Mercy Hospital, University of Missouri at Kansas City, MO, USA.
    Severe hypercalcemia in infants is usually attributed to genetic etiologies and less commonly to acquired ones. An 8-week-old girl presented with failure to thrive, mild respiratory distress, and life-threatening hypercalcemia (23.5 mg/dL). Read More

    IBD due to PID: Inflammatory bowel disease caused by primary immunodeficiencies - Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm.
    Pediatr Allergy Immunol 2017 May 17. Epub 2017 May 17.
    Centre for Paediatrics, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a multifactorial pathogenesis with complex interactions between polygenetic predispositions and environmental factors. However, IBD can also be caused by monogenic diseases, such as primary immunodeficiencies (PID). Recently, an increasing number of these altogether rare diseases has been described to present often primarily, or solely as IBD. Read More

    Sarcoidosis in Israel: Clinical Outcome Status, Organ Involvement, and Long-Term Follow-Up.
    Lung 2017 May 15. Epub 2017 May 15.
    Pulmonary Department, Meir Medical Center, Tshernichovsky 59, 442801, Kfar Saba, Israel.
    Purpose: Sarcoidosis is a chronic granulomatous inflammatory disease of unknown etiology with heterogeneous outcomes. This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five-year period. Further, we compared our results to the 'World Association of Sarcoidosis and Other Granulomatous Disease' (WASOG) COS and the 'A Case Control Etiologic Study of Sarcoidosis' (ACCESS) instruments in order to evaluate their relevance to the Israeli population. Read More

    Silicone Injection-Related Granulomatous Hypercalcemia.
    Am J Med Sci 2017 May 29;353(5):492-494. Epub 2016 Apr 29.
    Division of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, Virginia. Electronic address:
    Cosmetic filler injections are known to cause a number of acute and chronic effects, including local inflammation, nodule formation and granulomatous reaction. The timeline of these events is highly variable, occurring from hours to decades following injection. In few cases, systemic effects have been observed. Read More

    Acremonium pneumonia in an AIDS patient.
    IDCases 2017 25;8:75-76. Epub 2017 Apr 25.
    Hofstra Northwell School of Medicine, United States.
    Acremonium is a saprophytic fungus mostly causing superficial skin, nail, or ocular infections after traumatic inoculation. However, it is being recently recognized as one of the opportunistic infections in immunocompromised patients including neutropenia, malignancies, chronic granulomatous disease (CGD) and transplant recipients. To our knowledge there have been no reported cases of Acremonium infection, related to HIV or AIDS. Read More

    Haploinsufficiency of NADPH oxidase subunit NCF2 is sufficient to accelerate full-blown lupus in NZM.2328 mice.
    Arthritis Rheumatol 2017 May 4. Epub 2017 May 4.
    Washington University School of Medicine in St Louis, St Louis, Missouri, 63110.
    Objective: We have previously established that NCF2 (Neutrophil cytosolic factor 2) is a lupus predisposing gene and identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. This study was undertaken to investigate the relationship between reduced leukocyte NADPH oxidase activity and immune dysregulation associated with SLE.

    Methods: We generated NCF2-null mice, in which NADPH oxidase activity is absent, on the non-autoimmune C57BL/6 background and on the NZM. Read More

    Cervicofacial Primary Cutaneous Actinomycosis: Surgical Treatment for Complete Remission of the Disease.
    J Craniofac Surg 2017 May;28(3):e269-e271
    Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Actinomycosis, an infectious bacterial disease caused by Actinomyces species, is very rare and is characterized by contiguous spreading, subacute to chronic granulomatous inflammation and the formation of multiple abscesses and sinus tracts that may discharge sulfur granules. Actinomycosis that presents on the skin without endogenous origin is called primary cutaneous actinomycosis, and the occurrence and treatment of primary cutaneous actinomycosis is rarely reported. This report describes the treatment of primary cervicofacial actinomycosis with a literature review, and emphasizes the importance of surgical option for complete remission of the disease. Read More

    Hepatic Capillariasis - Drug Targets.
    Infect Disord Drug Targets 2017 Apr 27. Epub 2017 Apr 27.
    Seth GSMC and KEM Hospital Mumbai. India.
    Zoonotic infections are increasingly becoming public health menaces and are usually transmitted to humans due to unsuitable environmental conditions. One of them is hepatic capillariasis, caused by the parasite Capillaria hepatica, primarily a disease of rodents, with hepatic manifestations in humans. Although its prevalence is very low, it can cause significant morbidity and mortality, with cases reported from all over the world. Read More

    Lupus miliaris disseminatus faciei: A resistant case with response to cyclosporine.
    Dermatol Ther 2017 Apr 26. Epub 2017 Apr 26.
    Lok Nayak Hospital, Address, 107 Cruikshank Street, Frenchville, Rockhampton, QLD 4701, Australia.
    Lupus miliaris disseminatus faciei (LMDF) is a chronic, inflammatory dermatosis of unknown etiology, characterized by multiple, monomorphic, symmetrical, reddish-brown papules over forehead, cheeks, and eyelids. Histopathology shows perifollicular epitheloid cell granuloma. Though numerous therapies, ranging from cyclines, macrolides, dapsone tranilast, isotretinoin, steroids, and tacrolimus have been tried, the results are inconsistent, except with systemic steroids. Read More

    Successful hepatectomy for hepatic abscess with chronic granulomatous disease: a case report.
    Surg Case Rep 2017 Dec 26;3(1):57. Epub 2017 Apr 26.
    Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, Gunma University, 3-39-33, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
    Background: Chronic granulomatous disease (CGD), a rare inherited disorder, is characterized by impaired ability of phagocytic cells to kill certain bacteria and fungi. Although liver abscess is a common manifestation of CGD, its optimal management in these patients is unknown. Here, we present a case of successful hepatectomy for hepatic abscess in a patient with CGD. Read More

    Fungal Rhinosinusitis: A Radiological Review With Intraoperative Correlation.
    Can Assoc Radiol J 2017 May;68(2):178-186
    Neuroradiology, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada.
    The interaction between fungi and the sinonasal tract results in a range of clinical presentations with a broad spectrum of clinical severity. The most commonly accepted classification system divides fungal rhinosinusitis into invasive and noninvasive subtypes based on histopathological evidence of tissue invasion by fungi. Invasive fungal rhinosinusitis is subdivided into acute invasive and chronic invasive categories. Read More

    Paecilomyces formosus Infection in an Adult Patient with Undiagnosed Chronic Granulomatous Disease.
    J Clin Immunol 2017 May 20;37(4):342-346. Epub 2017 Apr 20.
    Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    Rhinoscleroma: a chronic infectious disease of poor areas with characteristic histological features - report of a series of six cases.
    Trop Doct 2017 Jan 1:49475517704612. Epub 2017 Jan 1.
    1 Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Rhinoscleroma is a chronic infectious disease that is endemic in certain poor areas of the world. The diagnosis often relies on pathology, the outcome is disappointing and then marked by recurrence. We present a retrospective series of six patients histologically diagnosed with rhinoscleroma. Read More

    mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France.
    Emerg Infect Dis 2017 May;23(5):874-876
    We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance. Read More

    [Clinical features, risk factors and progresses on treatment of recurrent Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Apr;53(4):317-320
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Vogt-Koyanagi-Harada disease(VKH) is a bilateral, granulomatous panuveitis associated with central nervous system, auditory, and integumentary manifestations. Clinically, VKH usually responds well to early aggressive glucocorticosteroid treatment and may be cured without any clinically significant sequelae. Some patients, however, may enter the chronic recurrent phase, which may result in marked loss of vision due to complications such as complicated cataract, secondary glaucoma and maculopathy. Read More

    Anti-inflammatory and membrane stabilizing properties of methyl jasmonate in rats.
    Chin J Nat Med 2017 Mar;15(3):202-209
    Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences University of Ibadan, Ibadan, Nigeria.
    The present investigation was carried out to evaluate anti-inflammatory and membrane stabilizing properties of methyl jasmonate (MJ) in experimental rat models of acute and chronic inflammation. The effects of MJ on acute inflammation were assessed using carrageenan-induced rat's paw edema model. The granuloma air pouch model was employed to evaluate the effects of MJ on chronic inflammation produced by carrageenan in rats. Read More

    Brain-eating amoebae: Predilection sites in the brain and disease outcome.
    J Clin Microbiol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Biological Sciences, School of Science and Technology, Sunway University, Malaysia.
    Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection lasting few days, while GAE is a chronic to subacute infection that can last up to several months. Read More

    Nontuberculous mycobacterial infection of the musculoskeletal system in immunocompetent hosts.
    Indian J Orthop 2017 Mar-Apr;51(2):205-212
    Department of Pathology, Hinduja Hospital and Medical Research Center, Mumbai, Maharashtra, India.
    Background: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. Read More

    Single-centre experience of granulomatous interstitial nephritis-time for a new approach?
    Clin Kidney J 2017 Apr 7;10(2):249-254. Epub 2017 Jan 7.
    Renal Unit, King's College Hospital, London, UK.
    Background: Differentiating between renal-limited sarcoidosis and tuberculosis (TB) infection as a cause of granulomatous interstitial nephritis (GIN) can be difficult. This series compares clinical features and response to treatment between the different underlying aetiologies in order to propose a management algorithm for GIN to assist with diagnosis and treatment. Methods: This retrospective study reports on all patients presenting with a histological diagnosis of GIN between 2000 and 2012 at our unit. Read More

    Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma.
    J Ocul Pharmacol Ther 2017 May 10;33(4):325-333. Epub 2017 Apr 10.
    1 F.I. Proctor Foundation, University of California , San Francisco, San Francisco, California.
    Necrobiotic xanthogranuloma (NXG) is a chronic, progressive non-Langerhans histiocytic granulomatous disease. While case reports describing periorbital involvement of NXG are frequent, only a few case reports describing ocular involvement, such as scleritis and uveitis, exist. Herein, we present a case presenting initially as bilateral anterior and posterior scleritis, as well as a chronic bilateral granulomatous panuveitis, and discuss the immunosuppressant options that should be considered for this disease with protean manifestations. Read More

    Clinical Implications for the Timely Diagnosis of Mycobacterium marinum in the Age of Biologic Therapy: A Case Report and Review of the Literature.
    Case Rep Infect Dis 2017 14;2017:5274302. Epub 2017 Mar 14.
    Division of Infectious Diseases, Department of Internal Medicine, University of Calgary, Calgary, AB, Canada.
    Mycobacterium marinum infections typically present as cutaneous nodular lesions with a sporotrichoid lymphatic spread on extensor surfaces of extremities. The natural history of this infection can be altered if the host is immunosuppressed, leading to disseminated presentations. A detailed exposure history and high degree of suspicion for this indolent pathogen are often required for the correct diagnosis of this disease. Read More

    Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab.
    ACG Case Rep J 2017 29;4:e46. Epub 2017 Mar 29.
    Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal.
    Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. Read More

    Mycobacterium avium subsp. paratuberculosis (Map) Fatty Acids Profile Is Strain-Dependent and Changes Upon Host Macrophages Infection.
    Front Cell Infect Microbiol 2017 21;7:89. Epub 2017 Mar 21.
    Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Technological Park of BizkaiaDerio, Spain; Servicio Regional de Investigación y Desarrollo Agroalimentario, Agri-Food Research and Development Regional ServiceVillaviciosa, Spain.
    Johne's disease is a chronic granulomatous enteritis of ruminants caused by the intracellular bacterium Mycobacterium avium subsp. paratuberculosis (Map). We previously demonstrated that Map isolates from sheep persisted within host macrophages in lower CFUs than cattle isolates after 7 days of infection. Read More

    Chronic Granulomatous Disease Presenting as Aspergillus Fumigatus Pneumonia in a Previously Healthy Young Woman.
    Am J Case Rep 2017 Apr 5;18:351-354. Epub 2017 Apr 5.
    Department of Infectious Disease, Baptist Memorial Health Care, Memphis, TN, USA.
    BACKGROUND Chronic Granulomatous Disease (CGD) is a rare immunodeficiency disease caused by a genetic defect in the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase enzyme, resulting in increased susceptibility to bacterial and fungal infections. The inheritance can be X-linked or autosomal recessive. Patients usually present with repeated infections early in life. Read More

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