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    7074 results match your criteria Chronic Granulomatous Disease

    1 OF 142

    A Pilot Study Assessing the Ability of 5-Aminosalicylic Acid to Modulate the Immune Response in Chronic Beryllium Disease.
    Ann Am Thorac Soc 2018 Apr;15(Supplement_2):S133
    1 Division of Environmental and Occupational Health Sciences, Hollis Laboratory, Department of Medicine, National Jewish Health, Denver, Colorado; and.
    Chronic beryllium disease is a granulomatous lung disease, characterized by the accumulation of macrophages and beryllium-specific CD4 T-cells that proliferate and produce T-helper cell type 1 cytokines. Previous studies indicate that beryllium-mediated oxidative stress enhances cytokine response in chronic beryllium disease CD4 T-cells. 5-Aminosalicylic acid (5-ASA) is currently used to treat inflammatory bowel disease and has both antioxidant and antiinflammatory actions. Read More

    Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.
    Hum Gene Ther Clin Dev 2018 Apr 17. Epub 2018 Apr 17.
    1 Institute for Tumor Biology and Experimental Therapy , Georg-Speyer-Haus, Frankfurt, Germany .
    Chronic granulomatous disease (CGD) is a debilitating primary immunodeficiency affecting phagocyte function due to the absence of nicotinamide dinucleotide phosphate (NADPH) oxidase activity. The vast majority of CGD patients in the Western world have mutations within the X-linked CYBB gene encoding for gp91 (NOX2), the redox center of the NADPH oxidase complex (XCGD). Current treatments of XCGD are not entirely satisfactory, and prior attempts at autologous gene therapy using gammaretrovirus vectors did not provide long-term curative effects. Read More

    A clinical threat in patients with granulomatosis polyangiitis in remission: Subglottic stenosis.
    Eur J Rheumatol 2018 Mar 11;5(1):69-71. Epub 2017 Apr 11.
    Division of Rheumatology, Department of Internal Medicine, Süleyman Demirel University School of Medicine, Isparta, Turkey.
    Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous disease that involves small- and medium-sized arteries and affects the main respiratory tracts and kidneys. Upper respiratory tract involvement usually occurs in 90% of patients, who most frequently present with symptoms of chronic sinusitis. Subglottic stenosis (SS) is a rare and severe complication that is usually observed in approximately 15% of patients. Read More

    ISMap element targeted nested polymerase chain in the detection of subsp. in fecal samples of cattle and buffaloes.
    Vet World 2018 Mar 31;11(3):397-401. Epub 2018 Mar 31.
    Animal Disease Research Centre, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.
    Background And Aim: Johne's disease is chronic granulomatous enteritis which affects ruminants. There are many diagnostic approaches for the detection of subsp. (MAP) of which molecular detection methods using various elements are less time consuming and more accurate. Read More

    A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report.
    J Med Case Rep 2018 Apr 13;12(1):94. Epub 2018 Apr 13.
    Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, TAC 441 South, P.O. Box 208057, New Haven, CT, 06520, USA.
    Background: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy. Read More

    Iatrogenic pulmonary lesions.
    Semin Diagn Pathol 2018 Mar 23. Epub 2018 Mar 23.
    Service de Pneumologie et Soins Intensifs Respiratoires, Hopital du Bocage Centre Hospitalier Universitaire (CHU) de Bourgogne, Dijon, France; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France; INSERM U866, Faculté de Médecine, Dijon, France.
    Treatment of patients often includes the administration of medications and sometimes radiation. While the intent is to treat an underlying condition, in some cases, adverse effects occur due to these agents. Most of these adverse effects are mild, however, some can be severe and life-threatening. Read More

    High Incidence of Autoimmune Disease Post HSCT for Chronic Granulomatous Disease.
    Biol Blood Marrow Transplant 2018 Apr 6. Epub 2018 Apr 6.
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital Cancer Center and Houston Methodist Hospital, Houston TX. Electronic address:
    There is a lack of consensus regarding the role and method of Hematopoietic Stem Cell Transplantation (HSCT) on patients with Chronic Granulomatous Disease (CGD), Long term follow up after HSCT in these patient population is essential in order to know its potential complications and decide who will benefit the most from HSCT. We report the outcome of HSCT and long term follow up in 24 patients with CGD, transplanted in our center from either related (N=6) or unrelated (n=18) donors, over a 12-year period (2003-2015) using high dose alemtuzumab in the preparative regimen . We evaluated the incidence and timing of adverse events and potential risk factors. Read More

    Pulmonary sarcoidosis.
    Lancet Respir Med 2018 Apr 3. Epub 2018 Apr 3.
    Royal Brompton and Harefield National Health Service Foundation Trust, Interstitial Lung Disease Unit, London, UK.
    Sarcoidosis is a granulomatous disease of unknown cause, occurs worldwide and has a highly variable prevalence. The disease is typically dominant in the lungs, although it can affect virtually any organ and is unpredictable in its clinical course. The severity of pulmonary sarcoidosis ranges from incidentally discovered radiographic abnormalities in asymptomatic patients to a chronic progressive disease that is refractory to treatment. Read More

    [Ocular manifestations in Behçet's disease].
    Rev Med Interne 2018 Apr 3. Epub 2018 Apr 3.
    Sorbonne universités, UPMC université Paris 06, UMR 7211, et DHU i2B-inflammation-immunopathologie-biothérapie, 75005 Paris, France; Inserm, UMR_S 959, 75013 Paris, France; CNRS, FRE3632, 75005 Paris, France; Département de médecine interne et d'immunologie clinique, université Pierre-et-Marie-Curie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75013 Paris, France; Centre national de référence des maladies auto-immunes systémiques rares, centre national de référence des maladies auto-inflammatoires et de l'amylose, France. Electronic address:
    Ocular disease in Behçet's disease is frequent and may be associated with a poor functional prognosis. Uveitis is the most common ocular manifestation in Behçet's disease and represents a diagnostic criterion of the disease. The ocular involvement is inaugural of the disease in 20% of the cases or may develop 2 to 3 years after the beginning of the extraocular signs. Read More

    Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.
    Mol Ther 2018 Mar 10. Epub 2018 Mar 10.
    Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:
    We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising. We developed a distinctly different approach using c-kit CAR-T cells. Read More

    Autoimmune/inflammatory syndrome induced by mineral oil: a health problem.
    Clin Rheumatol 2018 Apr 4. Epub 2018 Apr 4.
    Unidad Médica de Alta Especiad, Hospital de Especialidades "Dr. Antonio Fraga Mouret," Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
    Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) includes the following conditions: siliconosis, Gulf War syndrome, macrophagic myofasciitis syndrome, and post-vaccination phenomena. Afterward, other syndromes have been recognized, such as in ASIA by mineral oil (ASIA-MO). These conditions are triggered by adjuvants and they are the result of the interplay of genetic and environmental factors. Read More

    A rare yet emerging cause of bacterial meningitis.
    IDCases 2018 9;11:61-63. Epub 2018 Jan 9.
    Department of Pharmacy, University Medical Center of El Paso, El Paso, TX, 79905, USA.
    is a member of the complex. Although it is usually associated with infections in patients with cystic fibrosis, chronic granulomatous disease, and immunosuppression, central nervous infections are not commonly reported. Moreover, management of these infections is difficult due to multiple mechanisms of bacterial resistance to antimicrobial agents. Read More

    NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages.
    Blood 2018 Apr 4. Epub 2018 Apr 4.
    Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, United States;
    The phagocyte NADPH oxidase generates superoxide, the precursor to reactive oxygen species (ROS) that have both antimicrobial and immunoregulatory functions. Inactivating mutations in NADPH oxidase alleles cause chronic granulomatous disease (CGD), characterized by enhanced susceptibility to life-threatening microbial infections and inflammatory disorders, and hypomorphic NADPH oxidase alleles are associated with autoimmunity. Impaired apoptotic cell (AC) clearance is implicated as an important contributing factor in chronic inflammation and autoimmunity, but the role of NADPH oxidase-derived ROS in this process is incompletely understood. Read More

    Last station in the eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis march: Eosinophilic asthma with radiological findings associated with blood eosinophilia.
    J Asthma 2018 Apr 3:1-7. Epub 2018 Apr 3.
    b Department of Chest Diseases , Erciyes University School of Medicine , Kayseri , Turkey.
    Objective: Eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis (EA-CRS/NP) is a subphenotype of adult-onset eosinophilic asthma. Blood eosinophil levels are shown to be highly elevated in patients with EA-CRS/NP and have potential for tissue infiltration. We aimed to demonstrate the clinical features of the patients who have a blood eosinophil level above 10% and have thorax computed tomography findings due to blood eosinophilia. Read More

    Diagnostic adequacy and safety of endoscopic ultrasound-guided fine-needle aspiration in patients with lymphadenopathy in a large cohort.
    Endosc Int Open 2018 Apr 29;6(4):E421-E424. Epub 2018 Mar 29.
    Institute of Digestive and Hepatobiliary Sciences, Medanta The Medicity, Gurugram, India.
    Background And Study Aims : The role of endoscopic-ultrasound (EUS) guided fine-needle aspiration (FNA) in patients with lymphadenopathy in terms of diagnostic adequacy and safety in large population is not well defined. The aim of this study was to evaluate diagnostic adequacy and safety of EUS-FNA in patients with lymphadenopathy.

    Patients And Methods:  Retrospective study from October 2010 to September 2015 at tertiary care center in Delhi-NCR. Read More

    Intraabdominal actinomycosis resulting in a difficult to diagnose intraperitoneal mass: A case report.
    Int J Surg Case Rep 2018 Mar 21;45:101-103. Epub 2018 Mar 21.
    Department of Pathology, Kinki Central Hospital, Hyogo, Japan.
    Introduction: Actinomycosis is a chronic suppurative granulomatous disease caused by Actinomyces israelii. Preoperative confirmed diagnosis is very difficult, so most cases are diagnosed preoperatively as malignant tumors. We report a case of intraabdominal actinomycosis which was difficult to diagnose preoperatively. Read More

    [The diagnostic algorithm of practice in pulmonary and extrapulmonary sarcoidosis].
    Pol Merkur Lekarski 2018 Mar;44(261):101-109
    Department of Pulmonology, Medical University of Gdansk, Poland.
    Sarcoidosis (SA) is a granulomatous multisystem disease of unknown ethiology. Pulmonary, lymphadenopathy, liver, spleen, skin, and bone sarcoidosis are more frequent but also SA of the heart, central nervous system, eye, and hypercalcemia with following kidney failure also occur. Sarcoidosis may co-exist with extrapulmonary forms, which may overtake or precede each other. Read More

    Morphological and molecular characterization of Paragonimus caliensis Little, 1968 (Trematoda: Paragonimidae) from Medellin and Pichinde, Colombia.
    Acta Trop 2018 Mar 27;183:95-102. Epub 2018 Mar 27.
    Área de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Facultat de Farmàcia, Universitat de València, 46100 Burjassot, Valencia, Spain; Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute La Fe, Universitat de Valencia, 46010 Valencia, Spain.
    Paragonimiasis is a subacute to chronic inflammatory granulomatous lung disease caused by the genus Paragonimus. In Latin America Paragonimus mexicanus Miyazaki & Ishii, 1968 is the only confirmed species to cause human infections. Paragonimus caliensis Little, 1968 is an uncommon species often regarded as a synonym of P. Read More

    Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung.
    MBio 2018 Mar 27;9(2). Epub 2018 Mar 27.
    Molecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA
    Invasive aspergillosis (IA) remains the primary cause of morbidity and mortality in chronic granulomatous disease (CGD) patients, often due to infection by species refractory to antifungals. This motivates the search for alternative treatments, including immunotherapy. We investigated the effect of exogenous type I interferon (IFN) activation on the outcome of IA caused by three species, , , and , in CGD mice. Read More

    Incidental Findings in Routine Histopathological Examination of Appendectomy Specimens; Retrospective Analysis of 1970 Patients.
    Indian J Surg 2018 Feb 17;80(1):48-53. Epub 2016 Oct 17.
    2Department of Pathology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
    Diseases and tumors of the appendix vermiformis are very rare, except for acute appendicitis. This study aimed to examine rare findings in the histopathologic examinations of specimens of patients undergoing appendectomy due to the diagnosis of acute appendicitis. The files of 1970 patients undergoing appendectomy due to the diagnosis of acute appendicitis between March 2012 and March 2016 were retrospectively investigated. Read More

    Social geography of Rhinoscleroma and qualitatively and quantitatively abnormal cell-mediated immunity.
    Infect Genet Evol 2018 Mar 22;62:17-19. Epub 2018 Mar 22.
    Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy.
    Rhinoscleroma is a progressive chronic granulomatous disease of the upper respiratory tract that may extend to the tracheobronchial tract. It is common belief that the pathology is determined by Klebsiella Rhinoscleromatis. In the authors' opinion, the infection with Klebsiella Rhinoscleromatis may not represent the only etiopathogenic factor of the disease. Read More

    Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91 , phagocyte flavocytochrome b large subunit.
    Microbiol Immunol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Biochemistry, Kawasaki Medical School, 577 Matsushima Kurashiki, Okayama 701-0192, Japan.
    Human phagocyte flavocytochrome b (Cyt b), the catalytic center of NADPH oxidase, consists of a heavily glycosylated large subunit (gp91 , Nox2) and a small subunit (p22 ). Cyt b is a membrane-spanning complex enzyme. Chronic granulomatous disease (CGD) is predominantly caused by a mutation in the CYBB gene encoding gp91 on the X-chromosome. Read More

    Action and function of Chromobacterium violaceum in health and disease: Violacein as a promising metabolite to counteract gastroenterological diseases.
    Best Pract Res Clin Gastroenterol 2017 Dec 12;31(6):649-656. Epub 2017 Oct 12.
    Biological Chemistry Laboratory, Institute of Chemistry, Universidade Estadual de Campinas, CP 6154, 13083-970, Campinas, SP, Brazil; NanoBioss, Institute of Chemistry, Universidade Estadual de Campinas, Campinas, SP, Brazil; LNNano (CNPEM), Campinas, SP, Brazil. Electronic address:
    Chromobacterium violaceum is a Gram negative, β-proteobacterium found in the microbiota of tropical and subtropical environments. Although considered an opportunistic pathogen, infection rapidly progress to fatal sepsis, with metastatic abscesses. It is noteworthy the multidrug resistant phenotype of C. Read More

    Hepatic Sarcodosis presenting as portal hypertension in a young boy.
    Gastroenterol Hepatol Bed Bench 2018 ;11(1):83-85
    Department of Hepato-gastroenterology, Sindh Institute of Urology and Transplantation, (SIUT), Civil Hospital Karachi 74200, Karachi, Pakistan.
    A 13-year-old boy, known case renal stone disease came with the complaints of abdominal pain along with low grade fever. On examination, hepatosplenomegaly was noted while his lab reports showed a low hemoglobulin with a raised ESR. His blood and urine cultures showed no growth. Read More

    A Cohort of 169 Chronic Granulomatous Disease Patients Exposed to BCG Vaccination: a Retrospective Study from a Single Center in Shanghai, China (2004-2017).
    J Clin Immunol 2018 Mar 20. Epub 2018 Mar 20.
    Department of Allergy and Clinical Immunology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
    Purpose: Clinical diagnosis and treatment for chronic granulomatous disease (CGD) have advanced greatly in recent years. However, CGD patients in China have unique clinical features and infection spectrums, which are challenging to their caretakers. Here, we summarized the clinical characteristics, genetic features, treatment, and prognosis of CGD in a single center in Shanghai. Read More

    G908R NOD2 variant in a family with sarcoidosis.
    Respir Res 2018 Mar 20;19(1):44. Epub 2018 Mar 20.
    Université Paris 13, Sorbonne Paris Cité, Laboratoire EA2363 "Hypoxie et Poumon", 74 rue Marcel Cachin, 93017, Bobigny cedex, France.
    Background: Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in response to unidentified antigens in individuals with genetic susceptibility. The present study aimed to determine the genetic variants implicated in a familial case of sarcoidosis. Read More

    TNF-α blockade impairs in vitro tuberculous granuloma formation and down modulate Th1, Th17 and Treg cytokines.
    PLoS One 2018 15;13(3):e0194430. Epub 2018 Mar 15.
    Laboratory of Immunology, Department of Biological Sciences, Triângulo Mineiro Federal University, Uberaba, Minas Gerais, Brazil.
    Tuberculosis (TB) is a granulomatous disease that has affected humanity for thousands of years. The production of cytokines, such as IFN-γ and TNF-α, is fundamental in the formation and maintenance of granulomas and in the control of the disease. Recently, the introduction of TNF-α-blocking monoclonal antibodies, such as Infliximab, has brought improvements in the treatment of patients with chronic inflammatory diseases, but this treatment also increases the risk of reactivation of latent tuberculosis. Read More

    Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China.
    World J Gastroenterol 2018 Mar;24(9):1035-1045
    Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang Province, China.
    Aim: To analyze clinical differences between monogenic and nonmonogenic very-early-onset inflammatory bowel disease (VEO-IBD) and to characterize monogenic IBD phenotypically and genotypically genetic testing.

    Methods: A retrospective analysis of children aged 0 to 6 years diagnosed with VEO-IBD in a tertiary hospital in southern China from 2005 to 2017 was performed. Clinical data for VEO-IBD patients were collected, and genetic characteristics were analyzed using whole exome sequencing or target gene panel sequencing. Read More

    High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing.
    Mol Ther Nucleic Acids 2018 Mar 10;10:1-8. Epub 2017 Nov 10.
    Department of Molecular Hematology, Goethe University Medical School, 60590 Frankfurt am Main, Germany; LOEWE Center for Cell and Gene Therapy, Goethe University Medical School, 60590 Frankfurt am Main, Germany.
    The CRISPR/Cas9 prokaryotic adaptive immune system and its swift repurposing for genome editing enables modification of any prespecified genomic sequence with unprecedented accuracy and efficiency, including targeted gene repair. We used the CRISPR/Cas9 system for targeted repair of patient-specific point mutations in the Cytochrome b-245 heavy chain gene (CYBB), whose inactivation causes chronic granulomatous disease (XCGD)-a life-threatening immunodeficiency disorder characterized by the inability of neutrophils and macrophages to produce microbicidal reactive oxygen species (ROS). We show that frameshift mutations can be effectively repaired in hematopoietic cells by non-integrating lentiviral vectors carrying RNA-guided Cas9 endonucleases (RGNs). Read More

    Endobronchial Tuberculosis Simulating Carcinoid Tumor.
    J Coll Physicians Surg Pak 2018 Mar;28(3):S39-S41
    Medical Student, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
    Diagnosing endobronchial tuberculosis (EBTB) can be difficult due to the lack of specific signs and symptoms that differentiate it from other respiratory diseases, such as lung tumors. We hereby report a case of a very rare presentation of tuberculosis (TB) in a patient who presented with a dry cough and significant weight loss for 3 months. Chest X-ray and CT scan of the chest showed partial atelectasis and a segmental collapse of the right upper lobe and tumor-like arising from its bronchus along with a large right para-tracheal mediastinal lymphadenopathy, mimicking a metastatic (N2) disease. Read More

    Evaluation of infectious and non-infectious complications in patients with primary immunodeficiency.
    Cent Eur J Immunol 2017 30;42(4):336-341. Epub 2017 Dec 30.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Introduction: Primary immunodeficiency diseases (PIDs) are a heterogeneous group of genetic immune disorders. PID patients suffer from a variety of complications. The aim of this study was to determine the infectious and non-infectious complications among PID patients. Read More

    In-host microevolution of Aspergillus fumigatus: A phenotypic and genotypic analysis.
    Fungal Genet Biol 2018 Apr 23;113:1-13. Epub 2018 Feb 23.
    Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen, UK. Electronic address:
    In order to survive, Aspergillus fumigatus must adapt to specific niche environments. Adaptation to the human host includes modifications facilitating persistent colonisation and the development of azole resistance. The aim of this study is to advance understanding of the genetic and physiological adaptation of A. Read More

    Phylogenetic analysis of Histoplasma capsulatum var duboisii in baboons from archived formalin-fixed, paraffin embedded tissues.
    Med Mycol 2018 Feb 16. Epub 2018 Feb 16.
    Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
    Histoplasma capsulatum var. duboisii (Hcd) infections have been well documented to cause chronic granulomatous disease, mainly involving the skin of baboons and humans in African countries primarily. This retrospective study classified the subspecies of Histoplasma and developed a phylogenetic tree utilizing DNA sequences extracted from formalin-fixed, paraffin embedded (FFPE) tissues from 9 baboons from a research colony in Texas histologically diagnosed with Hcd. Read More

    Correction to: Chronic Granulomatous Disease in a Brazilian Patient Mimetizing Sarcoidosis.
    J Clin Immunol 2018 Feb;38(2):221
    Medicina do Centro Universitário Lusíada - UNILUS, Santos, Brazil.
    The original version of abstract PO-162 "Chronic Granulomatous Disease in a Brazilian Patient Mimetizing Sarcoidosis" incorrectly listed the name of the second author as Micheli Barsioti. The correct spelling of the author's name is Michele Baziotti Man. Read More

    Mycophenolate mofetil as a successful therapy for idiopathic granulomatous mastitis.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Harvard Medical School, Boston, Massachusetts.
    Idiopathic granulomatous mastitis (IGM) is a benign chronic inflammatory breast disease of unknown etiology. No consensus exists as to the best therapeutic approach, though treatment choices include antibiotics, drainage, surgical excision, steroids, methotrexate, and observation. Herein we report a case of idiopathic granulomatous mastitis that was refractory to methotrexate and intralesional and systemic steroids but responded well to mycophenolate mofetil 1500mg twice daily. Read More

    Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection.
    ACS Infect Dis 2018 Mar 1. Epub 2018 Mar 1.
    Department of Internal Medicine, UT Southwestern , 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
    The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens in immunocompromised individuals, such as those with cystic fibrosis (CF) or chronic granulomatous disease (CGD). Burkholderia are intrinsically resistant to many antibiotics and the lack of antibiotic development necessitates novel therapeutics. Peptide-conjugated phosphorodiamidate morpholino oligomers are antisense molecules that inhibit bacterial mRNA translation. Read More

    Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice.
    Comp Med 2018 Feb;68(1):4-14
    Department of Veterinary Biosciences, Center for Retrovirus Research, College of Veterinary Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH;, Email:
    Chronic infection with human T-cell leukemia virus type 1 (HTLV1) can lead to adult T-cell leukemia (ATL). In contrast, infection with HTLV2 does not lead to leukemia, potentially because of distinct virus-host interactions and an active immune response that controls virus replication and, therefore, leukemia development. We created a humanized mouse model by injecting human umbilical-cord stem cells into the livers of immunodeficient neonatal NSG mice, resulting in the development of human lymphocytes that cannot mount an adaptive immune response. Read More

    Identification of antigenic proteins from Mycobacterium avium subspecies paratuberculosis cell envelope by comparative proteomic analysis.
    Microbiology 2018 Mar 24;164(3):322-337. Epub 2018 Jan 24.
    1​Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
    Johne's disease (JD) is a contagious, chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). The aim of this study was to identify antigenic proteins from the MAP cell envelope (i. Read More

    Gingival enlargement unveiling Crohn's disease - A report of a rarefied case.
    J Indian Soc Periodontol 2017 Jul-Aug;21(4):326-328
    Department of Periodontics, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India.
    This article highlights a peculiar case of Crohn's disease (CD) with the primary presenting symptom as localized gingival overgrowth in the anterior region of maxilla. The patient underwent surgical treatment with external bevel gingivectomy procedure. Follow-up after 6 months revealed no recurrence. Read More

    Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama.
    Rev Inst Med Trop Sao Paulo 2018 15;60:e8. Epub 2018 Feb 15.
    Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama.
    Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V. Read More

    Development of a recombinase polymerase amplification assay for rapid detection of Francisella noatunensis subsp. orientalis.
    PLoS One 2018 14;13(2):e0192979. Epub 2018 Feb 14.
    Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling, Scotland, United Kingdom.
    Francisella noatunensis subsp. orientalis (Fno) is the causative agent of piscine francisellosis in warm water fish including tilapia. The disease induces chronic granulomatous inflammation with high morbidity and can result in high mortality. Read More

    NADPH Oxidase Deficiency: A Multisystem Approach.
    Oxid Med Cell Longev 2017 21;2017:4590127. Epub 2017 Dec 21.
    Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
    The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes. The generation and release of ROS in the form of an "oxidative burst" represent the pivotal mechanism by which phagocytic cells are able to destroy pathogens. Read More

    Mucocutaneous Manifestations of Infection by Histoplasma capsulatum in HIV-Negative Immunosuppressed Patients.
    Actas Dermosifiliogr 2018 Feb 8. Epub 2018 Feb 8.
    Servicio de Dermatología, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
    Histoplasmosis is a systemic mycosis caused by the dimorphous fungus Histoplasma capsulatum (H. capsulatum). The fungus enters the body through the respiratory tract in the form of microconidia, which are transformed into intracellular yeast-like structures in the lungs before disseminating hematogenously. Read More

    Late-onset postoperative Mycobacterium haemophilum endophthalmitis masquerading as inflammatory uveitis: a case report.
    BMC Infect Dis 2018 02 7;18(1):70. Epub 2018 Feb 7.
    Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand.
    Background: Although atypical mycobacteria had been increasingly found in various ocular infections in the past decades, a slow-growing Mycobacterium haemophilum (M. haemophilum) was scarcely reported. Similar to tuberculous infection, the presentation can masquerade as low-grade granulomatous intraocular inflammation with partial response to corticosteroids. Read More

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