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    7745 results match your criteria Chronic Fatigue Syndrome

    1 OF 155

    Negative Affectivity, Depression, and Resting Heart Rate Variability (HRV) as Possible Moderators of Endogenous Pain Modulation in Functional Somatic Syndromes.
    Front Psychol 2018 6;9:275. Epub 2018 Mar 6.
    Health Psychology, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium.
    Several studies have shown that patients with functional somatic syndromes (FSS) have, on average, deficient endogenous pain modulation (EPM), as well as elevated levels of negative affectivity (NA) and high comorbidity with depression and reduced resting heart rate variability (HRV) compared to healthy controls (HC). The goals of this study were (1) to replicate these findings and (2) to investigate the moderating role of NA, depression, and resting HRV in EPM efficiency within a patient group with fibromyalgia and/or chronic fatigue syndrome (CFS). Resting HRV was quantified as the root mean square of successive differences between inter-beat intervals (RMSSD) in rest, a vagally mediated time domain measure of HRV. Read More

    Beyond total treatment effects in randomised controlled trials: Baseline measurement of intermediate outcomes needed to reduce confounding in mediation investigations.
    Clin Trials 2018 Mar 1:1740774518760300. Epub 2018 Mar 1.
    2 Centre for Biostatistics, School of Health Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    Background: Random allocation avoids confounding bias when estimating the average treatment effect. For continuous outcomes measured at post-treatment as well as prior to randomisation (baseline), analyses based on (A) post-treatment outcome alone, (B) change scores over the treatment phase or (C) conditioning on baseline values (analysis of covariance) provide unbiased estimators of the average treatment effect. The decision to include baseline values of the clinical outcome in the analysis is based on precision arguments, with analysis of covariance known to be most precise. Read More

    HPV vaccination syndrome: A clinical mirage, or a new tragic fibromyalgia model.
    Reumatol Clin 2018 Mar 13. Epub 2018 Mar 13.
    Departamento de Reumatología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. Electronic address:
    Independent investigators have described the onset of a chronic painful dysautonomic syndrome soon after human papillomavirus (HPV) vaccination. The veracity of this syndrome is hotly debated. Many of the reported post-HPV vaccination cases fullfill fibromyalgia diagnostic criteria. Read More

    Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME.
    PLoS One 2018 15;13(3):e0193672. Epub 2018 Mar 15.
    Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Introduction: Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) point to an autoimmune disease directed against neurotransmitter receptors. We had observed elevated autoantibodies against ß2 adrenergic receptors, and muscarinic 3 and 4 acetylcholine receptors in a subset of patients. Immunoadsorption (IA) was shown to be effective in removing autoantibodies and improve outcome in various autoimmune diseases. Read More

    Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls.
    Pharmacoecon Open 2018 Mar 13. Epub 2018 Mar 13.
    International Centre for Evidence in Disability, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
    Background: People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continue to struggle to have their condition recognised as disabling in the face of public and professional prejudice and discrimination.

    Objective: The aim of this study was to compare the functional status and well-being of people with well-characterised ME/CFS with people with multiple sclerosis (PWMS), as well as healthy controls (HCs).

    Methods: In this cross-sectional study, we used data collected as part of the UK ME/CFS Biobank to compare actual participant scores from the Medical Outcomes Survey Short Form-36 v2™ (SF-36v2™) between groups, as a proxy for impact of disability, and from a bespoke questionnaire seeking data on employment and income. Read More

    Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?
    Clin Sci (Lond) 2018 Mar 9;132(5):523-542. Epub 2018 Mar 9.
    Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, U.K.
    Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (ME/CFS) is a disabling and debilitating disease of unknown aetiology. It is a heterogeneous disease characterized by various inflammatory, immune, viral, neurological and endocrine symptoms. Several microbiome studies have described alterations in the bacterial component of the microbiome (dysbiosis) consistent with a possible role in disease development. Read More

    Predictors of sleep-disordered breathing in pregnancy.
    Am J Obstet Gynecol 2018 Feb 2. Epub 2018 Feb 2.
    Northwestern University, Chicago, IL.
    Background: Sleep-disordered breathing (SDB) is common in pregnancy, but there are limited data on predictors.

    Objectives: The objective of this study was to develop predictive models of sleep-disordered breathing during pregnancy.

    Study Design: Nulliparous women completed validated questionnaires to assess for symptoms related to snoring, fatigue, excessive daytime sleepiness, insomnia, and restless leg syndrome. Read More

    Clinical Criteria of Central Sensitization in Chronic Pelvic and Perineal Pain (Convergences PP Criteria): Elaboration of a Clinical Evaluation Tool Based on Formal Expert Consensus.
    Pain Med 2018 Mar 7. Epub 2018 Mar 7.
    Federative Pelvic Pain Center, Department of Urology.
    Background: The evaluation of chronic pelvic and perineal pain (CPP) is often complex. The patient's description of the pain often appears to be disproportionate to the limited findings on physical examination and/or complementary investigations. The concept of central sensitization may allow better understanding and management of patients with CPP. Read More

    Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach.
    Auton Neurosci 2018 Feb 22. Epub 2018 Feb 22.
    Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Research & Innovation Hub, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK. Electronic address:
    Fatigue is a significant symptom that is frequently reported by those with postural tachycardia syndrome (PoTS). There are a variety of reasons why those with PoTS might experience fatigue and as a consequence an individualised approach to management is most appropriate. In this chapter we will examine the prevalence of fatigue in those with PoTS, its overlap with conditions such as chronic fatigue syndrome and describe a clinical approach to the management of fatigue in those with PoTS. Read More

    Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome.
    Auton Neurosci 2018 Mar 5. Epub 2018 Mar 5.
    Department of Pediatrics, Johns Hopkins University School of Medicine, 200 N. Wolfe St., Room 2077, Baltimore, MD 21287, USA. Electronic address:
    Objective: To review the association between orthostatic intolerance syndromes and both joint hypermobility and Ehlers-Danlos syndrome, and to propose reasons for identifying hereditary connective tissue disorders in those with orthostatic intolerance in the context of both clinical care and research.

    Methods: We searched the published peer-reviewed medical literature for papers reporting an association between joint hypermobility or Ehlers-Danlos syndrome and orthostatic intolerance.

    Results: We identified 10 relevant papers. Read More

    Low- and high-anxious hypermobile Ehlers-Danlos syndrome patients: comparison of psychosocial and health variables.
    Rheumatol Int 2018 Mar 1. Epub 2018 Mar 1.
    Department of Physical Medicine and Rehabilitation, Hôtel-Dieu Hospital, Paris, France.
    Despite the frequent co-ocurrence of hypermobile Ehler-Danlos syndrome (hEDS) and pathological anxiety, little is known about the psychosocial and health implications of such comorbidity. Our aim was to explore the association between high levels of anxiety and psychosocial (catastrophizing, kinesiophobia, somatosensory amplification, social support and functioning), health (pain, fatigue, BMI, tobacco/alcohol use, depression, diagnosis delay, general health), and sociodemographic factors in people with hEDS. In this cross-sectional study, 80 hEDS patients were divided into two groups according to self-reported anxiety levels: low and high. Read More

    Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.
    Front Immunol 2018 15;9:229. Epub 2018 Feb 15.
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden.
    Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent findings and placed them in the context of the clinical picture and natural history of the disease. Read More

    Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia.
    Cochrane Database Syst Rev 2018 02 28;2:CD010292. Epub 2018 Feb 28.
    Health Care Center for Pain Medicine and Mental Health, Saarbrücken, Germany.
    Background: Fibromyalgia is a clinically defined chronic condition of unknown etiology characterized by chronic widespread pain that often co-exists with sleep disturbances, cognitive dysfunction and fatigue. People with fibromyalgia often report high disability levels and poor quality of life. Drug therapy, for example, with serotonin and noradrenaline reuptake inhibitors (SNRIs), focuses on reducing key symptoms and improving quality of life. Read More

    Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions.
    Front Cell Neurosci 2018 13;12:35. Epub 2018 Feb 13.
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, United States.
    Centralized pain syndromes are associated with changes within the central nervous system that amplify peripheral input and/or generate the perception of pain in the absence of a noxious stimulus. Examples of idiopathic functional disorders that are often categorized as centralized pain syndromes include fibromyalgia, chronic pelvic pain syndromes, migraine, and temporomandibular disorder. Patients often suffer from widespread pain, associated with more than one specific syndrome, and report fatigue, mood and sleep disturbances, and poor quality of life. Read More

    Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide.
    J Autoimmun 2018 Feb 24. Epub 2018 Feb 24.
    CNRS, Biotechnology and Cell Signaling, University of Strasbourg, France; Laboratory of Excellence Medalis, France; University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France. Electronic address:
    Sjögren's syndrome is a multifactorial systemic autoimmune disorder characterized by lymphocytic infiltrates in exocrine organs. Patients present with sicca symptoms, such as extensive dry eyes and dry mouth, and parotid enlargement. Other serious complications include profound fatigue, chronic pain, major organ involvement, neuropathies and lymphomas. Read More

    Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island.
    Epidemiol Infect 2018 Feb 28:1-9. Epub 2018 Feb 28.
    INSERM CIC 1410,CHU Réunion,Saint Pierre,Reunion.
    Prolonged fatigue is increasingly reported among chikungunya virus (CHIKV)-infected populations. We investigated the relationships between CHIKV exposure, long-lasting rheumatic musculoskeletal pain (LRMSP) and chronic fatigue. 1094 participants (512 CHIKV seropositive and 582 seronegative) of the TELECHIK population-based cohort were analysed considering the duration of the manifestations throughout an average 2-year follow-up. Read More

    Association of chronic fatigue syndrome with premature telomere attrition.
    J Transl Med 2018 Feb 27;16(1):44. Epub 2018 Feb 27.
    Division of High-Consequence Pathogens & Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329, USA.
    Background: Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a severely debilitating condition of unknown etiology. The symptoms and risk factors of ME/CFS share features of accelerated aging implicated in several diseases. Using telomere length as a marker, this study was performed to test the hypothesis that ME/CFS is associated with accelerated aging. Read More

    Healthy Settings in Hospital - How to Prevent Burnout Syndrome in Nurses: Literature Review.
    Acta Clin Croat 2017 Jun;56(2):292-298
    Quality Control Department, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
    Healthy settings involve a holistic and multidisciplinary method that integrates actions towards risk factors. In hospital settings, a high level of stress can lead to depression, anxiety, decreased job satisfaction and lower loyalty to the organization. Burnout syndrome can be defined as physical, psychological and emotional exhaustion, depersonalization, and low sense of personal accomplishment. Read More

    The X-Y factor: Females and males with urologic chronic pelvic pain syndrome present distinct clinical phenotypes.
    Can Urol Assoc J 2018 Feb 23. Epub 2018 Feb 23.
    Department of Urology, Queen's University, Kingston, ON, Canada.
    Introduction: Urological chronic pelvic pain syndrome (UCPPS) in females is often attributed to the bladder (interstitial cystitis/bladder pain syndrome), while UCPPS in males is often attributed to the prostate (chronic prostatitis/chronic pelvic pain syndrome). However, there is increasing awareness that bladder pain plays a role in both males and females and the degree of overlap of clinical characteristics in males and females with UCPPS is not well known. Our objective was to compare clinical phenotypes of females and males with UCPPS. Read More

    Correction to: Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.
    J Transl Med 2018 Feb 23;16(1):39. Epub 2018 Feb 23.
    Psychology Department, College of Health and Biomedicine, Victoria University, Melbourne, Australia.
    The original version of this article [1], published on 6 February 2018, contains a mistake in the 'Conclusions' section. The corrected version of the affected sentence is given below and the corrected part is marked in bold. Read More

    Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to Activity Management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): protocol for a randomised controlled trial.
    Trials 2018 Feb 22;19(1):136. Epub 2018 Feb 22.
    Centre for Child and Adolescent Health, Bristol Medical School: Population Health Sciences, University of Bristol, Oakfield House, Oakfield, Grove, Bristol, BS8 2BN, UK.
    Background: Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition. The National Institute for Health and Clinical Excellence (NICE) recommends Cognitive Behavioural Therapy (CBT) as a treatment option for paediatric CFS/ME because there is good evidence that it is effective. Despite this, most young people in the UK are unable to access local specialist CBT for CFS/ME. Read More

    The role of spousal relationships in fibromyalgia patients' quality of life.
    Psychol Health Med 2018 Feb 23:1-9. Epub 2018 Feb 23.
    b School of Nursing , Oregon Health & Science University , Portland , OR , USA.
    Fibromyalgia (FM) is a chronic pain syndrome that includes debilitating symptoms such as widespread pain and tenderness, fatigue, and poor physical functioning. Research has shown FM patients' choice of coping style and relationship quality with their spouse can impact their mental quality of life (QoL), but no known study has examined the protective nature of relationship quality and coping behaviors on both patient physical and mental QoL in the context of chronic pain. We examined 204 patients with FM on the (a) roles of coping styles and relationship quality on patient quality of life, and (b) moderating effect of relationship quality on the association between negative coping style and patient QoL. Read More

    A Systematic Review of Probiotic Interventions for Gastrointestinal Symptoms and Irritable Bowel Syndrome in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
    Probiotics Antimicrob Proteins 2018 Feb 20. Epub 2018 Feb 20.
    National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia.
    Gastrointestinal (GI) symptoms and irritable bowel (IB) symptoms have been associated with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The aim of this study was to conduct a systematic review of these symptoms in CFS/ME, along with any evidence for probiotics as treatment. Pubmed, Scopus, Medline (EBSCOHost) and EMBASE databases were searched to source relevant studies for CFS/ME. Read More

    Fatigue in chronically critically ill patients following intensive care - reliability and validity of the multidimensional fatigue inventory (MFI-20).
    Health Qual Life Outcomes 2018 Feb 20;16(1):37. Epub 2018 Feb 20.
    Department of Psychotherapy and Psychosomatic Medicine, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden Fetscherstraße 74, 01307, Dresden, Germany.
    Background: Fatigue often occurs as long-term complication in chronically critically ill (CCI) patients after prolonged intensive care treatment. The Multidimensional Fatigue Inventory (MFI-20) has been established as valid instrument to measure fatigue in a wide range of medical illnesses. Regarding the measurement of fatigue in CCI patients, the psychometric properties of the MFI-20 have not been investigated so far. Read More

    Medical Cannabis for the Treatment of Fibromyalgia.
    J Clin Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Background: Fibromyalgia is a chronic pain syndrome, characterized by chronic musculoskeletal pain, fatigue, and mood disturbances. There are nearly no data on the effect of medical cannabis (MC) treatment on patients with fibromyalgia.

    Methods: Data were obtained from the registries of 2 hospitals in Israel (Laniado Hospital and Nazareth Hospital) on patients with a diagnosis of fibromyalgia who were treated with MC. Read More

    A reexamination of the cognitive behavioral model of chronic fatigue syndrome.
    J Clin Psychol 2018 Feb 19. Epub 2018 Feb 19.
    DePaul University.
    Objective: The cognitive behavioral model of chronic fatigue syndrome (CFS) suggests that cognitions and reduced activity level perpetuate the fatigue and impairment that individuals with CFS experience. The two empirical evaluations of this model resulted in conflicting findings. The current study examines the influence of case definition fulfillment on the applicability of this model to CFS. Read More

    Concurrent validation of a pressure pain threshold scale for individuals with myofascial pain syndrome and fibromyalgia.
    J Man Manip Ther 2018 Feb 9;26(1):25-35. Epub 2017 Jul 9.
    Physical Therapy Program, University of Central Florida, Orlando, FL, USA.
    Background: Manual pressure palpation is an examination technique used in the classification of myofascial pain syndrome (MPS) and fibromyalgia (FM). Currently, there are no validated systems for classifying results. A valid and reliable pressure pain threshold scale (PPTS) may provide a means for clinicians to grade, document, and report findings. Read More

    Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome.
    J Psychosom Res 2018 Mar 11;106:49-55. Epub 2018 Jan 11.
    Health Psychology, University of Leuven, Belgium. Electronic address:
    Objective: Dyspnea perception is distorted in patients with medically unexplained dyspnea. The goals of this study were 1) to replicate these results in patients with fibromyalgia and/or chronic fatigue syndrome (CFS), and 2) to investigate predictors of distorted symptom perception within the patient group, with a focus on negative affectivity (NA), psychiatric comorbidity and somatic symptom severity.

    Methods: Seventy-three patients diagnosed with fibromyalgia and/or CFS and 38 healthy controls (HC) completed a rebreathing paradigm, consisting of a baseline (60s of room air), a rebreathing phase (150s, gradually increasing ventilation, partial pressure of COin the blood, and self-reported dyspnea), and a recovery phase (150s of room air). Read More

    Sleep Quality in Well-defined Lyme Disease: A Clinical Cohort Study in Maryland.
    Sleep 2018 Feb 14. Epub 2018 Feb 14.
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.
    Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Read More

    Attention-deficit/hyperactivity disorder, joint hypermobility-related disorders and pain: expanding body-mind connections to the developmental age.
    Atten Defic Hyperact Disord 2018 Feb 14. Epub 2018 Feb 14.
    Division of Medical Genetics, IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
    Attention-deficit/hyperactivity disorder (ADHD) and generalized joint hypermobility (JH) are two separated conditions, assessed, and managed by different specialists without overlapping interests. Recently, some researchers highlighted an unexpected association between these two clinical entities. This happens in a scenario of increasing awareness on the protean detrimental effects that congenital anomalies of the connective tissue may have on human health and development. Read More

    Establishing a clinical phenotype for cachexia in end stage kidney disease - study protocol.
    BMC Nephrol 2018 Feb 13;19(1):38. Epub 2018 Feb 13.
    School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast and Regional Nephrology Unit, Belfast City Hospital, Belfast HSC Trust, Belfast, UK.
    Background: Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some evidence of muscle wasting. ESKD is associated with an increase in inflammatory cytokines and can result in cachexia, with the loss of muscle and fat stores. Read More

    Efficacy of web-based cognitive-behavioural therapy for chronic fatigue syndrome: randomised controlled trial.
    Br J Psychiatry 2018 Feb;212(2):112-118
    Academic Medical Center (AMC),University of Amsterdam,Department of Medical Psychology,Amsterdam Public Health Research Institute,Amsterdam,the Netherlands.
    Background: Face-to-face cognitive-behavioural therapy (CBT) leads to a reduction of fatigue in chronic fatigue syndrome (CFS). Aims To test the efficacy of internet-based CBT (iCBT) for adults with CFS.

    Method: A total of 240 patients with CFS were randomised to either iCBT with protocol-driven therapist feedback or with therapist feedback on demand, or a waiting list. Read More

    Differentiating Multiple Sclerosis from Myalgic Encephalomyelitis and Chronic Fatigue Syndrome.
    Insights Biomed 2017 12;2(2). Epub 2017 Jun 12.
    College of Science and Health, DePaul University, USA.
    Multiple Sclerosis (MS), Myalgic Encephalomyelitis (ME), and Chronic Fatigue syndrome are debilitating chronic illnesses, with some overlapping symptoms. However, few studies have compared and contrasted symptom and disability profiles for these illnesses for the purpose of further differentiating them. The current study was an online self-report survey that compared symptoms from a sample of individuals with MS (N = 120) with a sample of individuals with ME or CFS (N = 269). Read More

    Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
    Sci Rep 2018 Feb 9;8(1):2779. Epub 2018 Feb 9.
    Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA.
    Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous syndrome in which patients often experience severe fatigue and malaise following exertion. Immune and cardiovascular dysfunction have been postulated to play a role in the pathophysiology. We therefore, examined whether cytokine profiling or cardiovascular testing following exercise would differentiate patients with ME/CFS. Read More

    Revolving door respiratory patients: A rehabilitative perspective.
    Monaldi Arch Chest Dis 2017 Sep 22;87(3):857. Epub 2017 Sep 22.
    University Hospital St. Orsola-Malpighi, Medical Department of Continuity of Care and Disability.
    Rehabilitation is an integral component of care for patients affected by either acute or chronic pulmonary diseases. The key elements of rehabilitation treatment for critical respiratory patients are as follows: weaning from mechanical ventilation, respiratory therapy, physical reconditioning, and occupational therapy. It should be noted that patients affected by pulmonary diseases are prone to hospital re-admission due to frequent exacerbations, especially in cases with more severe stages of chronic obstructive pulmonary disease. Read More

    On chronic fatigue syndrome and nosological categories.
    Clin Rheumatol 2018 Feb 7. Epub 2018 Feb 7.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 5265601, Tel-Hashomer, Israel.
    Chronic fatigue syndrome (CFS) is a heterogeneous disease which presents with pronounced disabling fatigue, sleep disturbances, and cognitive impairment that negatively affects patients' functional capability. CFS remains a poorly defined entity and its etiology is still in question. CFS is neither a novel diagnosis nor a new medical condition. Read More

    Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome.
    Saudi J Anaesth 2018 Jan-Mar;12(1):112-114
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
    A subset of patients who had Lyme disease experience postinfectious signs or symptoms called post-treatment Lyme disease syndrome (PTLDS). PTLDS is a chronic condition including pain in joints and muscles, neurological symptoms including demyelinating diseases, peripheral neuropathy, headaches, sleep disturbances, fatigue, and cardiac conditions. We report a case of difficult acute pain management in a patient with PTLDS who underwent dental extractions and required admission to an intensive care unit for pain control. Read More

    A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications.
    Mol Neurobiol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
    Currently, a psychologically based model is widely held to be the basis for the aetiology and treatment of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME)/systemic exertion intolerance disease (SEID). However, an alternative, molecular neurobiological approach is possible and in this paper evidence demonstrating a biological aetiology for CFS/ME/SEID is adduced from a study of the history of the disease and a consideration of the role of the following in this disease: nitric oxide and peroxynitrite, oxidative and nitrosative stress, the blood-brain barrier and intestinal permeability, cytokines and infections, metabolism, structural and chemical brain changes, neurophysiological changes and calcium ion mobilisation. Evidence is also detailed for biologically based potential therapeutic options, including: nutritional supplementation, for example in order to downregulate the nitric oxide-peroxynitrite cycle to prevent its perpetuation; antiviral therapy; and monoclonal antibody treatment. Read More

    Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.
    J Transl Med 2018 Feb 6;16(1):24. Epub 2018 Feb 6.
    Psychology Department, College of Health and Biomedicine, Victoria University, Melbourne, Australia.
    Background: Preliminary evidence suggests that the enteric microbiota may play a role in the expression of neurological symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Overlapping symptoms with the acute presentation of D-lactic acidosis has prompted the use of antibiotic treatment to target the overgrowth of species within the Streptococcus genus found in commensal enteric microbiota as a possible treatment for neurological symptoms in ME/CFS.

    Methods: An open-label, repeated measures design was used to examine treatment efficacy and enable sex comparisons. Read More

    Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis.
    Am J Med Sci 2018 Feb 8;355(2):195-200. Epub 2017 Apr 8.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
    Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disease characterized by multiple organ system involvement, including renal disease, with low complement levels. We report the case of a 31-year-old woman who presented with nonspecific symptoms including fatigue, diarrhea, macular rash and abdominal pain with acute renal failure leading to end-stage kidney disease. Laboratory results showed hematuria, nephrotic range proteinuria, worsening creatinine and low C1q levels. Read More

    Is There a Link Between Obstructive Sleep Apnea Syndrome and Fibromyalgia Syndrome?
    Turk Thorac J 2017 Apr 1;18(2):40-46. Epub 2017 May 1.
    Department of Mental Health and Diseases, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.
    Objectives: Fibromyalgia syndrome (FMS) is characterized by complaints of chronic musculoskeletal pain, fatigue, and difficulty in falling asleep. Obstructive sleep apnea syndrome (OSAS) is associated with symptoms, such as morning fatigueness and unrefreshing sleep. We aimed to investigate the presence of OSAS and objectively demonstrate changes in sleep pattern in patients with FMS. Read More

    Cardiovascular characteristics of chronic fatigue syndrome.
    Biomed Rep 2018 Jan 28;8(1):26-30. Epub 2017 Nov 28.
    Interdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, I-27100 Pavia, Italy.
    Patients with chronic fatigue syndrome (CFS) commonly exhibit orthostatic intolerance. Abnormal sympathetic predominance in the autonomic cardiovascular response to gravitational stimuli was previously described in numerous studies. The aim of the current study was to describe cardiological and clinical characteristics of Italian patients with CFS. Read More

    Rethinking childhood adversity in chronic fatigue syndrome.
    Fatigue 2018 10;6(1):20-29. Epub 2017 Oct 10.
    Wolfson Research Unit, Newcastle University, Newcastle, UK.
    Previous studies have consistently shown increased rates of childhood adversity in chronic fatigue syndrome (CFS). However, such aetiopathogenic studies of CFS are potentially confounded by co-morbidity and misdiagnosis particularly with depression.We examined the relationship between rates of childhood adversity using two complimentary approaches (1) a sample of CFS patients who had no lifetime history of depression and (2) a modelling approach. Read More

    Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis.
    J Transl Med 2018 Feb 2;16(1):21. Epub 2018 Feb 2.
    Maryland Spine Center, Mercy Medical Center, 301 St. Paul Place, Baltimore, MD, 21201, USA.
    Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients with severe ME/CFS whose symptoms improved after recognition and surgical management of their cervical spinal stenosis. Read More

    A Herbal Medicine,, in Subjects with Chronic Dizziness (GOODNESS Study): Study Protocol for a Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Clinical Trial for Effectiveness, Safety, and Cost-Effectiveness.
    Evid Based Complement Alternat Med 2017 13;2017:4363716. Epub 2017 Dec 13.
    Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
    This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication,(GJD), in patients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight patients diagnosed with Meniere's disease, psychogenic dizziness, or dizziness of unknown cause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Read More

    Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort.
    Arch Dis Child 2018 Jan 30. Epub 2018 Jan 30.
    Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
    Objective: To investigate associations of physical activity at age 11 years with chronic disabling fatigue (CDF) at ages 13 and 16 years.

    Design: Longitudinal birth cohort.

    Setting: South-West England. Read More

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