7,853 results match your criteria Chronic Fatigue Syndrome


Effects of a short-term aquatic exercise intervention on symptoms and exercise capacity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a pilot study.

Eur J Appl Physiol 2018 Jun 19. Epub 2018 Jun 19.

School of Health and Human Sciences, Southern Cross University, PO Box 157, Lismore, NSW, 2480, Australia.

Purpose: This pilot pre-and post-intervention study investigated the effects of a short-term aquatic exercise programme on physiological outcomes, symptoms and exercise capacity in women with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Methods: Eleven women (54.8 ± 12. Read More

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and compound heterozygous mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome.

Mol Genet Metab Rep 2018 Sep 15;16:23-29. Epub 2018 Jun 15.

Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115, USA.

Complex phenotypes may represent novel syndromes that are the composite interaction of several genetic and environmental factors. We describe an 9-year old male with high functioning autism spectrum disorder and Muckle-Wells syndrome who at age 5  years of age manifested perseverations that interfered with his functioning at home and at school. After age 6, he developed intermittent episodes of fatigue and somnolence lasting from hours to weeks that evolved over the course of months to more chronic hypersomnia. Read More

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September 2018

Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants.

Lancet Public Health 2018 Jun 13. Epub 2018 Jun 13.

General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, 1 Horselethill Road, Glasgow, G12 9LX, Scotland, United Kingdom. Electronic address:

Background: Frailty is associated with older age and multimorbidity (two or more long-term conditions); however, little is known about its prevalence or effects on mortality in younger populations. This paper aims to examine the association between frailty, multimorbidity, specific long-term conditions, and mortality in a middle-aged and older aged population.

Methods: Data were sourced from the UK Biobank. Read More

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June 2018
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Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen - Case Series Presentation and Suggested Bio-Psycho-Social Mechanism.

Front Psychol 2018 29;9:848. Epub 2018 May 29.

The Emili Sagol CAT Research Center, Graduate School of Creative Arts Therapies, University of Haifa, Haifa, Israel.

Fibromyalgia Syndrome (FMS) is a condition considered to represent a prototype of central sensitization syndrome, characterized by chronic widespread pain and along with symptoms of fatigue, non-restorative sleep and cognitive difficulties. FMS can be induced by trauma, infection or emotional stress with cumulative evidence that dissociation is relatively frequent in FMS patients. Two randomized controlled trials have shown that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and be effective in patients suffering from FMS. Read More

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May 2018
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Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature.

Z Gastroenterol 2018 06 11;56(6):573-577. Epub 2018 Jun 11.

GI Physiology Unit, Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.

Eosinophilic colitis is a rare clinical condition that belongs to the group of eosinophilic gastrointestinal disorders. Its occurrence can be primary or secondary to infection, medications, or autoimmune/hematological conditions. We present a case of a young female adult with severe chronic fatigue syndrome, widespread chronic pain, including functional abdominal pain, who developed severe eosinophilic colitis following successive treatments with gabapentin and pregabalin. Read More

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Sleepiness, fatigue, anxiety and depression in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea - Overlap - Syndrome, before and after continuous positive airways pressure therapy.

PLoS One 2018 11;13(6):e0197342. Epub 2018 Jun 11.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.

Patients with Chronic Obstructive Pulmonary Disease (COPD) and / or Obstructive Sleep Apnea (OSA) often complain about sleepiness, fatigue, anxiety and depression. However, common screening questionnaires, like Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS) and Hospital Anxiety and Depression Scale (HADS) have not been previous evaluated in patients with overlap-coexisting COPD and OSA-syndrome versus patients with OSA alone. Our study compared ESS, FSS and HADS between patients with overlap syndrome and patients with OSA, before and after treatment with Continuous Positive Airways Pressure (CPAP). Read More

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The biopolitics of CFS/ME.

Authors:
Nikos Karfakis

Stud Hist Philos Biol Biomed Sci 2018 Jun 8. Epub 2018 Jun 8.

Business School, Alexander College/University of the West of England, 2 Artas Street, Aradippou 7110, Larnaca, Cyprus. Electronic address:

This paper argues that Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) constitutes a biopolitical problem, a scientific object which needs to be studied, classified and regulated. Assemblages of authorities, knowledges and techniques make CFS/ME subjects and shape their everyday conduct in an attempt to increase their supposed autonomy, wellbeing and health. CFS and CFS/ME identities are however made not only through government, scientific, and medical interventions but also by the patients themselves, a biosocial community who collaborates with scientists, educates itself about the intricacies of biomedicine, and contests psychiatric truth claims. Read More

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Giardiasis: a diagnosis that should be considered regardless of the setting.

Epidemiol Infect 2018 Jun 11:1-3. Epub 2018 Jun 11.

Academic Clinical and Surgical Hospital 'Calixto García',La Habana,Cuba.

Although Giardia, the aetiological agent of giardiasis, is one of the most prevalent intestinal parasitic infections world-wide, for industrialised countries, it is mainly appreciated as an imported disease with the minimal local transmission. However, the current evidence challenges this perception; Giardia has relevance beyond the high prevalence areas. This infection may be asymptomatic or cause gastrointestinal complains and long-term sequelae, including irritable bowel syndrome, chronic fatigue and impaired child growth and cognitive development. Read More

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June 2018
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How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors.

Am J Gastroenterol 2018 Jun 8. Epub 2018 Jun 8.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: The diagnostic criteria for irritable bowel syndrome (IBS) have recently been updated from Rome III to Rome IV. Whereas in Rome III a diagnosis of IBS entailed chronic abdominal pain or discomfort at least 3 days per month, in Rome IV the term discomfort has been removed and the frequency of abdominal pain increased to at least 1 day per week. We examined how this change in IBS criteria impacts on clinical characteristics and pathophysiological factors. Read More

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June 2018
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The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia.

Int J Pharm Compd 2018 May-Jun;22(3):252-256

Pacific University School of Pharmacy, Hillsboro, Oregon.

Fibromyalgia is a syndrome associated with chronic, widespread musculoskeletal pain, fatigue, depression, and cognitive dysfunction. With few U.S. Read More

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June 2018
3 Reads

[Chronic adrenal insufficiency: an underestimated cause of chronic fatigue].

Pan Afr Med J 2018 30;29:93. Epub 2018 Jan 30.

Faculté de Médecine de Libreville, Libreville, Gabon.

Chronic adrenal insufficiency is regarded as a rare disease in its primary stage. However, secondary adrenal insufficiency, which essentially occurs after stopping corticosteroids, is more frequent, ranging from 4.2% to 60%, depending on the pathology treated, but it is often unrecognized. Read More

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June 2018
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Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

PLoS One 2018 6;13(6):e0198106. Epub 2018 Jun 6.

CFS/ME Unit, Vall d'Hebron University Hospital Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients frequently show autonomic symptoms which may be associated with a hypothalamic dysfunction. This study aimed to explore circadian rhythm patterns in rest and activity and distal skin temperature (DST) and their association with self-reported outcome measures, in CFS/ME patients and healthy controls at two different times of year. Ten women who met both the 1994 CDC/Fukuda definition and 2003 Canadian criteria for CFS/ME were included in the study, along with ten healthy controls matched for age, sex and body mass index. Read More

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Operationalizing Substantial Reduction in Functioning Among Young Adults with Chronic Fatigue Syndrome.

Int J Behav Med 2018 Jun 5. Epub 2018 Jun 5.

Center for Community Research, DePaul University, 990 W Fullerton Avenue, Suite 3100, Chicago, IL, 60614, USA.

Purpose: Chronic fatigue syndrome and myalgic encephalomyelitis are fatiguing illnesses that often result in long-term impairment in daily functioning. In reviewing case definitions, Thrope et al. (Fatigue 4(3):175-188, 2016) noted that the vast majority of case definitions used to describe these illnesses list a "substantial reduction" in activities as a required feature for diagnosis. Read More

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Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Front Immunol 2018 9;9:1028. Epub 2018 May 9.

ME/CFS Unit, ASSSEMBiomédics, Barcelona, Spain.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a pathological condition characterized by incapacitating fatigue and a combination of neurologic, immunologic, and endocrine symptoms. At present its diagnosis is based exclusively on clinical criteria. Several studies have described altered immunologic profiles; therefore, we proposed to further examine the more significant differences, particularly T and NK cell subpopulations that could be conditioned by viral infections, to discern their utility in improving the diagnosis and characterization of the patients. Read More

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May 2018
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Two-Year Follow-Up of Impaired Range of Motion in Chronic Fatigue Syndrome.

J Pediatr 2018 Jun 1. Epub 2018 Jun 1.

Rick Violand PT, LLC, Ellicott City, MD.

Objective: To measure changes in range of motion (ROM) over time in a cohort of 55 adolescents and young adults with chronic fatigue syndrome and to determine whether changes in ROM correlated with changes in health-related quality of life.

Study Design: Participants underwent a standardized examination of 11 areas of limb and spine ROM at baseline and at 3- to 6-month intervals for 2 years, resulting in a ROM score that ranged from 0 (normal throughout) to 11 (abnormal ROM in all areas tested). We measured the time until the ROM score was ≤2 (the score in healthy age-matched controls). Read More

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June 2018
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Activity and Exercise Intolerance After Concussion: Identification and Management of Postural Orthostatic Tachycardia Syndrome.

J Neurol Phys Ther 2018 Jul;42(3):163-171

Affilate Faculty, Doctor of Physical Therapy Program, Regis University, Denver, Colorado (N.M.); Marcus Institute for Brain Health, Aurora, Colorado (N.M.); University of Pennsylvania, Philadelphia (J.R.B.); Division of Cardiology, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania (J.R.B.); Physical Therapy Department Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (K.K.); and Dysautonomia International, East Moriches, New York (L.S.).

Background And Purpose: Postural orthostatic tachycardia syndrome (POTS) is increasingly recognized as a complication affecting recovery from concussion. Individuals with POTS demonstrate refractory dizziness, lightheadedness, cognitive dysfunction, fatigue, headache, chronic pain, nausea and gastrointestinal dysmotility, activity and exercise intolerance, syncope, and tachycardia. Subtypes of POTS may include hypovolemia, hyperadrenergic states, autonomic neuropathy, and underlying autoimmunity, which may variably impact response to rehabilitation in varying ways. Read More

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July 2018
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Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: a MAPP Research Network study.

Pain 2018 May 28. Epub 2018 May 28.

Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Chronic Overlapping Pain Conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This 'centralized pain' phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, and hypersensitivity to external stimuli. Here we used three cohorts, including patients with Urologic Chronic Pelvic Pain Syndrome (UCPPS), a mixed pain cohort with other COPCs, and healthy individuals (total n = 1039) from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network to explore the factor structure of symptoms of centralized pain. Read More

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May 2018
2 Reads

Successful outcome of musculoskeletal injury leads to a reduction in chronic fatigue: A case report.

Authors:
Carl Todd DO

J Bodyw Mov Ther 2018 Apr 21;22(2):281-286. Epub 2017 Jul 21.

The Carl Todd Clinic, 5 Pickwick Park, Park Lane, Corsham, Wiltshire, SN13 0HN, United Kingdom. Electronic address:

Background: Chronic fatigue syndrome (CFS) is a general term used to describe a number of medical conditions that lead to persistent levels of fatigue and distress.

Objectives: Osteopathic manipulative treatment (OMT) combined with shoulder exercises to resolve musculoskeletal sports injury may have also led to a reduction in pain and improved strength with the patient reporting a change in CFS levels.

Clinical Features: 19-year-old male student, (statue 194cm and mass 80kg) who had played county level cricket and hockey. Read More

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The role of mirtazapine in patients with fibromyalgia: a systematic review.

Rheumatol Int 2018 Jun 2. Epub 2018 Jun 2.

Pharmacy Department (119), Durham VA Medical Center, 508 Fulton St., Durham, NC, 27705, USA.

Mirtazapine is commonly used to treat major depressive disorder. Due to its effects on multiple neurotransmitters, it has been investigated for possible benefits in patients with fibromyalgia. The objective of this systematic review is to assess the efficacy and safety of mirtazapine in the treatment of patients with fibromyalgia. Read More

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June 2018
2 Reads

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis.

Med Hypotheses 2018 Jul 30;116:114-118. Epub 2018 Apr 30.

ENT Dept, University Hospital Centre "Sestre milosrdnice", Zagreb School of Medicine Zagreb, Croatia.

Epidemiological studies show female predominance in the prevalence of non- allergic rhinitis (NAR) and local allergic rhinitis (LAR). Experimental studies show female patients with allergic rhinitis (AR) demonstrate higher levels of sensitivity to irritants and airway hyperresponsiveness than males. Bronchial asthma shows female predominance in post-puberty patients, and gender interaction with severe asthma endotypes. Read More

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July 2018
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Deconstructing post-exertional malaise in myalgic encephalomyelitis/ chronic fatigue syndrome: A patient-centered, cross-sectional survey.

PLoS One 2018 1;13(6):e0197811. Epub 2018 Jun 1.

Stanford ME/CFS Initiative, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, United States of America.

Background: Post-exertional malaise (PEM) is considered to be the hallmark characteristic of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). Yet, patients have rarely been asked in formal studies to describe their experience of PEM.

Objectives: To describe symptoms associated with and the time course of PEM. Read More

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Cerebral blood flow and heart rate variability predict fatigue severity in patients with chronic fatigue syndrome.

Brain Imaging Behav 2018 May 31. Epub 2018 May 31.

Department of Medicine, College of Medicine, University of Florida, PO Box 100221, Gainesville, FL, 32610-0221, USA.

Prolonged, disabling fatigue is the hallmark of chronic fatigue syndrome (CFS). Previous neuroimaging studies have provided evidence for nervous system involvement in CFS etiology, including perturbations in brain structure/function. In this arterial spin labeling (ASL) MRI study, we examined variability in cerebral blood flow (CBFV) and heart rate (HRV) in 28 women: 14 with CFS and 14 healthy controls. Read More

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How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies.

J Immunol Res 2018 2;2018:1060421. Epub 2018 May 2.

Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

In the course of pSS, inflammatory cell infiltration consists mainly of lymphocytes infiltrating exocrine glands, which leads to their impaired function. The characteristic feature is generalized dryness. The aim of this study was to attempt to answer the question whether it is possible to distinguish between patients with pSS and individuals with dryness caused by other pathologies without applying invasive studies. Read More

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Structural brain changes versus self-report: machine-learning classification of chronic fatigue syndrome patients.

Exp Brain Res 2018 May 30. Epub 2018 May 30.

Department of Medicine, College of Medicine, University of Florida, PO Box 100277, Gainesville, 2610-0277, FL, USA.

Chronic fatigue syndrome (CFS) is a disorder associated with fatigue, pain, and structural/functional abnormalities seen during magnetic resonance brain imaging (MRI). Therefore, we evaluated the performance of structural MRI (sMRI) abnormalities in the classification of CFS patients versus healthy controls and compared it to machine learning (ML) classification based upon self-report (SR). Participants included 18 CFS patients and 15 healthy controls (HC). Read More

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Subjective Experiences and Sensitivities in Women with Fibromyalgia: A Quantitative and Comparative Study.

Pain Res Manag 2018 1;2018:8269564. Epub 2018 Apr 1.

Clinical Research Unit URC28, Dreux Hospital, GHT28, France.

Fibromyalgia is a chronic widespread pain syndrome associated with chronic fatigue. Its pathogenesis is not clearly understood. This study presents subjective experiences and sensitivities reported by fibromyalgia patients, which should be considered in primary care to avoid medical nomadism, as well as stigmatization of the patients. Read More

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April 2018
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Hair and salivary cortisol in a cohort of women with chronic fatigue syndrome.

Horm Behav 2018 May 29;103:1-6. Epub 2018 May 29.

Department of Psychology, University of Vienna, Vienna, Austria.

Hypocortisolism has been found in CFS patients in blood, urine, and saliva. It is unclear if hypocortisolism can also be demonstrated using long-term cortisol measurements, such as cortisol in hair. In addition, the interaction between the HPA axis and the immune system, both expected to play an important role in CFS, is unclear. Read More

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Advances in the diagnosis and treatment of Sjogren's syndrome.

Clin Rheumatol 2018 Jul 26;37(7):1743-1749. Epub 2018 May 26.

Institute of Clinical Pharmacology, Anhui Medical University, Hefei,, 230032, Anhui, China.

Sjogren's syndrome (SS) is a systemic autoimmune disease that primarily affects the exocrine glands, resulting in dryness of the eyes and mouth due to lymphocytic infiltration of the salivary and lacrimal glands along with arthritis, kidney, liver, and lung involvement, chronic fatigue, musculoskeletal pain, vasculitis, and so on. Considerable advance has been made for the classification and treatment of primary SS in the past few years. This article reviews the recent classification criteria for primary SS and briefly discusses the conventional and novel therapies of the disease. Read More

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July 2018
1 Read

Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome.

Biol Psychol 2018 May 23;136:87-99. Epub 2018 May 23.

Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA.

We investigated central fatigue in 50 patients with chronic fatigue syndrome (CFS) and 50 matched healthy controls (HC). Resting state EEG was collected from 19 scalp locations during a 3 min, eyes-closed condition. Current densities were localized using exact low-resolution electromagnetic tomography (eLORETA). Read More

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Towards a new classification of stable phase schizophrenia into major and simple neuro-cognitive psychosis: Results of unsupervised machine learning analysis.

J Eval Clin Pract 2018 May 23. Epub 2018 May 23.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Rationale: Deficit schizophrenia, as defined by the Schedule for Deficit Syndrome, may represent a distinct diagnostic class defined by neurocognitive impairments coupled with changes in IgA/IgM responses to tryptophan catabolites (TRYCATs). Adequate classifications should be based on supervised and unsupervised learning rather than on consensus criteria.

Methods: This study used machine learning as means to provide a more accurate classification of patients with stable phase schizophrenia. Read More

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May 2018
2 Reads

Comparison of Fatigue Severity and Quality of Life between Unexplained Fatigue Patients and Explained Fatigue Patients.

Korean J Fam Med 2018 May 18;39(3):180-184. Epub 2018 May 18.

Department of Family Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Background: Recently, despite the high prevalence of fatigue in patients, there is a lack of research on the quality of life (QoL) in unexplained fatigue patients, indicating that they are not properly diagnosed and treated. The aim of this study was to compare fatigue severity and QoL between patients with explained and unexplained fatigue.

Methods: The study consisted of 200 Korean adults who complained of fatigue without underlying disease. Read More

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Complete Hypokalemic Quadriparesis as a First Presentation of Sjögren Syndrome.

Can J Kidney Health Dis 2018 10;5:2054358118774536. Epub 2018 May 10.

Division of Nephrology and Immunology, Department Medicine, University of Alberta, Edmonton, Canada.

Rationale: We hope to increase awareness that hypokalemic paralysis may be the first presentation of Sjögren syndrome, for which potassium-sparing diuretics can be an effective adjunct to potassium replenishment.

Presenting Concerns: A 73-year-old female presented to a peripheral hospital with quadriparesis and a critically low serum potassium of 1.6 mmol/L with U waves on the electrocardiogram (ECG). Read More

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May 2018
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Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort.

Sleep Med 2018 Jun 31;46:26-36. Epub 2018 Jan 31.

Centre for Child and Adolescent Health, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK; Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK. Electronic address:

Objective/background: Sleep abnormalities are characteristic of chronic fatigue syndrome (CFS, also known as 'ME'), however it is unknown whether sleep might be a causal risk factor for CFS/ME.

Patients/methods: We analysed data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. We describe sleep patterns of children aged 6 months to 11 years, who were subsequently classified as having (or not having) 'chronic disabling fatigue' (CDF, a proxy for CFS/ME) between the ages 13 and 18 years, and we investigated the associations of sleep duration at age nine years with CDF at age 13 years, as well as sleep duration at age 11 years with CDF at age 16 years. Read More

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Dutch Health Council Advisory Report on Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: Taking the Wrong Turn.

Authors:
Frank Twisk

Diagnostics (Basel) 2018 May 16;8(2). Epub 2018 May 16.

ME-de-patiënten Foundation, Zonnedauw 15, 1906 HB Limmen, The Netherlands.

Recently, the Dutch Health Council published their advisory report on Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) which is meant to determine the medical policy with regard to ME in the Netherlands. The Health Council briefly discusses several diagnostic criteria and proposes to use new diagnostic criteria for "ME/CFS" in research and clinical practice in the future. The advisory report then summarizes organic abnormalities observed in the last decades and concludes that "ME/CFS" is a "serious, chronic, multisystem disease". Read More

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Antibodies Against GPCR.

Front Biosci (Landmark Ed) 2018 Jun 1;23:2177-2194. Epub 2018 Jun 1.

CellTrend GmbH, Im Biotechnologiepark TGZ II, 14943 Luckenwalde, Germany,

G-protein-coupled receptors (GPCRs) are the largest family of receptors in humans. GPCRs are seven-transmembrane receptors that are activated by the binding of a ligand to the extracellular domain. In addition to the endogenous ligands, auto-antibodies (aab) can also bind to the GPCRs. Read More

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June 2018
3 Reads

Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

J Sleep Res 2018 May 16:e12703. Epub 2018 May 16.

CFS/ME Unit, Internal Medicine Service, Vall d'Hebron University Hospital Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort. Read More

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May 2018
1 Read

Fibromyalgia Syndrome: A Case Report on Controlled Remission of Symptoms by a Dietary Strategy.

Front Med (Lausanne) 2018 30;5:94. Epub 2018 Apr 30.

Neurological Department, Ospedale Niguarda Ca' Granda, Milan, Italy.

A 34-year-old woman suffered from significant chronic pain, depression, non-restorative sleep, chronic fatigue, severe morning stiffness, leg cramps, irritable bowel syndrome, hypersensitivity to cold, concentration difficulties, and forgetfulness. Blood tests were negative for rheumatic disorders. The patient was diagnosed with Fibromyalgia syndrome (FMS). Read More

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April 2018
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The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Sleep Med Rev 2018 Apr 4. Epub 2018 Apr 4.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Addiction & Mental Health (CAMH), Toronto, ON, Canada. Electronic address:

Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders. Read More

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The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

Front Behav Neurosci 2018 26;12:78. Epub 2018 Apr 26.

Neuroimmunology Laboratory, Symptom Research Department, The University of Texas MD Anderson Cancer Institute, Houston, TX, United States.

Chronic or persistent fatigue is a common, debilitating symptom of several diseases. Persistent fatigue has been associated with low-grade inflammation in several models of fatigue, including cancer-related fatigue and chronic fatigue syndrome. However, it is unclear how low-grade inflammation leads to the experience of fatigue. Read More

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Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?

Open Access Rheumatol 2018 1;10:27-32. Epub 2018 May 1.

London School of Osteopathy, Department of Osteopathic Technique, London, UK.

Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%-6% of the developed countries' population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. Read More

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Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.

BMC Complement Altern Med 2018 May 8;18(1):149. Epub 2018 May 8.

Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul, 02447, South Korea.

Background: Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory and anti-nociceptive activities. However, its mechanisms of stress-induced depression remain unknown. Read More

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Patients with chronic fatigue syndrome do not score higher on the autism-spectrum quotient than healthy controls: Comparison with autism spectrum disorder.

Scand J Psychol 2018 May 8. Epub 2018 May 8.

Department of Medical Sciences, Örebro University, Örebro, Sweden.

Clinically, there is an overlap of several symptoms of chronic fatigue syndrome (CFS) and autism spectrum disorder (ASD), including fatigue; brain "fog"; cognitive impairments; increased sensitivity to sound, light, and odour; increased pain and tenderness; and impaired emotional contact. Adults with CFS (n = 59) or ASD (n = 50) and healthy controls (HC; n = 53) were assessed with the Autism-Spectrum Quotient (AQ) in a cross-sectional study. Non-parametric analysis was used to compare AQ scores among the groups. Read More

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May 2018
2 Reads

A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review.

J Neurol Neurosurg Psychiatry 2018 May 7. Epub 2018 May 7.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George's, University of London, London, UK.

Background: Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient cohorts. We hypothesised that cognitive profiles in fibromyalgia (FM), chronic fatigue syndrome (CFS) and functional neurological disorders (FNDs) would provide a template for characterising FCD. Read More

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Burnout in the staff of a chronic care hospital.

Rev Saude Publica 2018 3;52:45. Epub 2018 May 3.

Universidad de Granada, Granada, España.

OBJECTIVE To estimate the prevalence of Burnout in a medium or long-stay hospital, to monitor its evolution and to highlight the importance of cut-off points used to avoid distortions in the interpretation of the results. METHODS Two cross-sectional studies (2013-2016) were carried out, applying the Spanish version of the Maslach Burnout Inventory to the staff of a chronic care hospital (n = 323). Result variables were: Burnout prevalence and a high degree of affectation of the subscales and predictor variables: sociodemographic characteristics and factors that trigger and modulate the syndrome. Read More

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Pediatric chronic fatigue syndrome: current perspectives.

Authors:
Esther Crawley

Pediatric Health Med Ther 2017 29;9:27-33. Epub 2018 Mar 29.

Centre for Child and Adolescent Health, Bristol Medical School, University of Bristol, Bristol, UK.

Pediatric chronic fatigue syndrome is an important illness as it is relatively common and also very disabling with a wide range of impacts on the child, the family, and health care systems. It is a complicated illness but the majority of children get better with specialist treatment. This literature review provides an update on the epidemiology of chronic fatigue syndrome / myalgic encephalomyelitis, including factors associated with it, and discusses the current evidence for treatment. Read More

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Severe arthritic syndrome due to ibrutinib use for chronic lymphocytic leukemia.

J Oncol Pharm Pract 2018 Jan 1:1078155218772327. Epub 2018 Jan 1.

1 Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, CA, USA.

Although newer targeted agents improve survival in cancer patients, they have also been linked with unusual side effects. The most common side effects of Bruton tyrosine kinase inhibitors include fatigue, nausea, diarrhea, bruising, and cytopenias. We describe herein a case of an unusually severe articular syndrome with the use of ibrutinib in a patient with 17 p minus chronic lymphocytic leukemia. Read More

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January 2018

Robuvit®: improvement of fatigue in medical convalescence.

J Sports Med Phys Fitness 2018 05;58(5):678-683

Irvine3 Labs, Circulation Sciences, Department of Medical Sciences and Biotechnology, G. D'Annunzio University, Chieti, Italy.

Background: The aim of this registry study was the evaluation of symptoms of fatigue following supplementation with an oak wood extract (Robuvit®) after disappearance of acute symptoms. Robuvit®, with established antioxidant-antifatigue activity, has been successfully used in hepatic failure and in chronic fatigue syndrome: these conditions are characterized by weakness and fatigue and are broadly comparable to convalescence that is associated to increased oxidative stress.

Methods: The registry study lasted 3 weeks. Read More

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