8,181 results match your criteria Chronic Fatigue Syndrome


Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

J Psychosom Res 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatrics, Akershus University Hospital, Lørenskog N-1478, Norway.

Objective: Acute Epstein-Barr virus (EBV) infection is a known trigger of both acute and chronic fatigue. The aim of this study was to investigate associations to fatigue in adolescents with EBV infection during the initial stage and six months after, as well as in healthy controls.

Methods: 200 adolescents (12-20 years old) with EBV infection were assessed as soon as possible after the onset of symptoms (EBV) and six months later (EBV, 5 drop-outs). Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.04.008DOI Listing

Letter to the Editor: Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: Definitions, Similarities, and Differences.

Authors:
Frank N M Twisk

Clin Ther 2019 Apr 16. Epub 2019 Apr 16.

ME-de-patiënten Foundation, Limmen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2019.03.010DOI Listing

The post-aSAH syndrome: a self-reported cluster of symptoms in patients with aneurysmal subarachnoid hemorrhage.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Neurosurgery, Oslo University Hospital; and.

OBJECTIVEAlthough many patients recover to a good functional outcome after aneurysmal subarachnoid hemorrhage (aSAH), residual symptoms are very common and may have a large impact on the patient's daily life. The particular cluster of residual symptoms after aSAH has not previously been described in detail and there is no validated questionnaire that covers the typical problems reported after aSAH. Many of the symptoms are similar to post-concussion syndrome, which often is evaluated with the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Read More

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http://dx.doi.org/10.3171/2019.1.JNS183168DOI Listing

Meeting the Educational Needs of Young, ME/CFS Patients: Role of the Treating Physician.

Authors:
Faith R Newton

Front Pediatr 2019 2;7:104. Epub 2019 Apr 2.

Department of Education, Delaware State University, Dover, DE, United States.

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https://www.frontiersin.org/article/10.3389/fped.2019.00104/
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http://dx.doi.org/10.3389/fped.2019.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455006PMC
April 2019
1 Read

Corrigendum: Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

Front Neurol 2019 2;10:316. Epub 2019 Apr 2.

Division of Neurotherapeutics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

[This corrects the article DOI: 10.3389/fneur.2018. Read More

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http://dx.doi.org/10.3389/fneur.2019.00316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454267PMC

Cognitive factors are associated with disability and pain, but not fatigue among physiotherapy attendees with persistent pain and fatigue.

Physiotherapy 2019 Jan 19. Epub 2019 Jan 19.

School of Health Sciences, University of Salford, Allerton Building, Salford, Manchester, M6 6PU, UK; Department of Research and Innovation, Northern Care Alliance NHS Group, Summerfield House, 544 Eccles New Road, Salford, Greater Manchester, M5 5AP, UK.

Objectives: Most research exploring the relationship between cognitive factors and pain, disability and fatigue in patients with persistent pain/fatigue has been performed in multi disciplinary environments. It is unclear whether these associations are consistent in other contexts. This study therefore aimed to establish the relationships between these factors in patients with persistent pain/fatigue referred for physiotherapy treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319406193001
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http://dx.doi.org/10.1016/j.physio.2019.01.006DOI Listing
January 2019
1 Read

Hypermobile type Ehlers-Danlos syndrome associated with hypogammaglobulinemia and fibromyalgia: A case-based review on new classification, diagnosis, and multidisciplinary management.

Clin Case Rep 2019 Apr 19;7(4):680-685. Epub 2019 Feb 19.

Internal Medicine Residency Program Brookwood Baptist Health Birmingham Alabama.

Hypermobile type Ehlers-Danlos syndrome (hEDS) is an underdiagnosed connective tissue disorder characterized by generalized joint hypermobility, chronic fatigue, widespread joints pain, and impaired quality of life. Here, we reported the first hEDS complicated by hypogammaglobulinemia. New insights into classification, diagnosis, and proper management of hEDS are also reviewed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2070
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http://dx.doi.org/10.1002/ccr3.2070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452458PMC
April 2019
6 Reads

Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis.

Pharmacol Res 2019 Apr 13;144:158-166. Epub 2019 Apr 13.

Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Chronic atrophic gastritis (CAG) is a common digestive disease without specific treatment. According to syndrome differentiation, traditional Chinese medicine (TCM) classified it into different syndromes and has achieved significant therapeutic effects. In this study, immune repertoire sequencing techniques combined with symptom scores, electronic gastroscopy as well as pathologic changes were used to evaluate the effect and the underlying mechanism of Modified Sijunzi Decoction (MSD) in treating CAG. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.012DOI Listing
April 2019
1 Read

[Mufangji Decoction formula tracing and its effect on emergency and severe cases].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):388-400

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Mufangji Decoction is a famous herbal formula from Synopsis of Golden Chamber. However,it is easy to be misunderstood due to so its unique compatability. The syndromes treated by Mufangji Decoction included the following aspects:(1) in terms of modern medicine,it could be used to treat acute and chronic heart failure,heart failure aggravated by lung infection,chronic obstructive pulmonary disease acute episode,pulmonary heart disease,bilateral pleural effusion,acute attack of gout,rheumatic fever,rheumatoid arthritis,and rheumatoid arthritis;(2) in terms of symptoms,it could be used to treat asthma,chest tightness,wheeze impacting prostration and dyspnea impacting sitting posture; gastric distention; dark face,cyanotic,and mitral valvular face; edema of head and extremities; dry mouth,thirsty,unwilling to wear thick clothes,intolerance of heat,and irritable; fatigue,shortness of breath,poor appetite,constipation,less urine,yellow color,poor response to diuretics,and diuretic resistance; fast heart rate,which is hard to be controlled by Western medicine and has no response to Zhenwu Decoction; dark red tongue,dry tongue with yellow fur,rapid pulse,or deep tight pulse. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.2019.0009
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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0009DOI Listing
January 2019
2 Reads

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Insights & Advances in Care.

Authors:
Alison Bested

Altern Ther Health Med 2018 Jun;24(S1):32-33

No Abstract Available. Read More

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Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study.

Diagnostics (Basel) 2019 Apr 10;9(2). Epub 2019 Apr 10.

Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease presenting with extreme fatigue, post-exertional malaise, and other symptoms. In the absence of a diagnostic biomarker, ME/CFS is diagnosed clinically, although laboratory tests are routinely used to exclude alternative diagnoses. In this analytical cross-sectional study, we aimed to explore potential haematological and biochemical markers for ME/CFS, and disease severity. Read More

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http://dx.doi.org/10.3390/diagnostics9020041DOI Listing
April 2019
1 Read

Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

Front Pediatr 2019 22;7:82. Epub 2019 Mar 22.

Workwell Foundation, Ripon, CA, United States.

Post-exertional malaise (PEM) is the hallmark clinical feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PEM involves a constellation of substantially disabling signs and symptoms that occur in response to physical, mental, emotional, and spiritual over-exertion. Because PEM occurs in response to over-exertion, physiological measurements obtained during standardized exertional paradigms hold promise to contribute greatly to our understanding of the cardiovascular, pulmonary, and metabolic states underlying PEM. Read More

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http://dx.doi.org/10.3389/fped.2019.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439478PMC
March 2019
1 Read

Medically Unexplained Symptoms (MUS): Faults and Implications.

Authors:
Michiel Tack

Int J Environ Res Public Health 2019 Apr 8;16(7). Epub 2019 Apr 8.

Independent researcher, Sint-Laurentiusstraat 87, 9700 Oudenaarde, Belgium.

The classification of medically unexplained symptoms (MUS) could have negative consequences for patients with functional somatic syndromes (FSS). By grouping related but distinct syndromes into one label, the MUS classification fails to inform clinicians about their patients' health condition. In research settings, the MUS classification makes patient samples more heterogeneous, obstructing research into the underlying pathology of FSS. Read More

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http://dx.doi.org/10.3390/ijerph16071247DOI Listing
April 2019
1 Read

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome.

Polymers (Basel) 2018 Nov 15;10(11). Epub 2018 Nov 15.

Laboratory of Nutrition and Hygiene, Shaanxi Normal University, Xi'an 710119, China.

green tea was considered a medicine food homology plant to improve chronic fatigue Ssyndrome (CFS) in China. The aim of this research was to study the therapeutic effect of selenium-polysaccharides (Se-TP) from green tea on CFS and explore its metabolic mechanism. A CFS-rats model was established in the present research and Se-TP was administrated to evaluate the therapeutic effect on CFS. Read More

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http://www.mdpi.com/2073-4360/10/11/1269
Publisher Site
http://dx.doi.org/10.3390/polym10111269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401680PMC
November 2018
4 Reads

EBV-requisitioning physicians' guess on fatigue state 6 months after acute EBV infection.

BMJ Paediatr Open 2019 1;3(1):e000390. Epub 2019 Mar 1.

Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.

We assessed referring medical practitioner's ability to predict chronic fatigue development in adolescents presenting with acute infectious mononucleosis. Compared with being predicted as and were both strongly associated with developing fatigue 6 months later (OR 2.5, 95% CI 1. Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422241PMC
March 2019
1 Read

RIFD - A brief clinical research interview for functional somatic disorders and health anxiety.

J Psychosom Res 2019 Apr 2. Epub 2019 Apr 2.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

Objective: Epidemiological research in functional somatic disorders such as irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, and bodily distress syndrome and related conditions such as health (illness) anxiety is often based on self-reported questionnaires or layman interviews. This study presents and describes the Research Interview for Functional somatic Disorders (RIFD) and provides first data regarding RIFD's ability to identify cases with functional somatic disorders and health anxiety in a two-phase design following self-reported symptom questionnaires.

Methods: RIFD was performed by phone by trained family physicians on a stratified subsample of 1590 adults from a Danish general population cohort (n = 7493). Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.04.001DOI Listing
April 2019
2 Reads

A national Health and Work Strategy: a search for evidence.

Occup Med (Lond) 2019 Apr;69(2):118-125

Health and Safety Executive, Harpur Hill, Buxton, Derbyshire, UK.

Background: The Health and Safety Executive's new Health and Work Strategy is based on an up-to-date assessment of workplace health priorities. Rather than replicating traditional prioritization approaches, a broader assessment of health and work priorities was carried out using a range of stakeholders.

Aims: To develop a set of health priorities for further research and intervention activity. Read More

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http://dx.doi.org/10.1093/occmed/kqz001DOI Listing
April 2019
1 Read

Varied Presentation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Needs for Classification and Clinician Education: A Case Series.

Clin Ther 2019 Apr 1. Epub 2019 Apr 1.

Instituto de Química Médica (CSIC), Madrid, Spain.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, heterogeneous and serious disease. In this article, we analyze the cases of 3 patients with ME/CFS. Due to the disbeliefs, misconceptions, and stigmas that are attached to ME/CFS, patient diagnosis is made after years of disease progression. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.02.014DOI Listing
April 2019
1 Read

Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain.

Neurourol Urodyn 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Aims: The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.23995
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http://dx.doi.org/10.1002/nau.23995DOI Listing
April 2019
2 Reads

Depressive symptoms in adolescents with chronic fatigue syndrome (CFS): Are rates higher than in controls and do depressive symptoms affect outcome?

Clin Child Psychol Psychiatry 2019 Apr 4:1359104519838584. Epub 2019 Apr 4.

3 King's College London, UK.

Introduction:: Previous research has indicated that co-morbid depression is common in adolescents with chronic fatigue syndrome (CFS).

Objectives:: We sought to compare the characteristics of depressive symptoms in adolescents with CFS to those of healthy controls (HCs) and illness controls (adolescents with asthma).

Design:: Case-control study nested within a prospective clinical cohort. Read More

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http://dx.doi.org/10.1177/1359104519838584DOI Listing
April 2019
1 Read

Incidence and distribution of lower extremity reflux in patients with pelvic venous insufficiency.

Phlebology 2019 Apr 3:268355519840846. Epub 2019 Apr 3.

1 Center for Vein Restoration, Greenbelt, MD, USA.

Introduction: Women with pelvic venous insufficiency often present with lower extremity symptoms and manifestations of chronic venous disorders. The purpose of this investigation was to determine the incidence of lower extremity chronic venous disorders and the types and distribution of lower extremity veins involved in patients with a known diagnosis of pelvic venous insufficiency.

Methods: Between January 2012 and December 2015, we retrospectively reviewed the charts of 227 women with pelvic venous insufficiency as well as their lower extremity venous duplex investigations. Read More

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http://dx.doi.org/10.1177/0268355519840846DOI Listing
April 2019
2 Reads

[Clinical research of auricular gold-needle therapy in treatment of chronic fatigue syndrome of deficiency constitution].

Zhongguo Zhen Jiu 2019 Feb;39(2):128-32

Foshan Chinese Medicine Hospital Affiliated to Guangzhou University of TCM, Foshan 528000, Guangdong Province.

Objective: To observe the clinical therapeutic effects of auricular gold-needle therapy on chronic fatigue syndrome of deficiency constitution and explore its potential mechanism.

Methods: A total of 120 patients were randomized into an auricular gold-needle therapy group, an auricular point pressure therapy group and a Chinese herb group, 40 cases in each one. Additionally, a health control group (40 cases) was set up, without any intervention. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2019.02.004DOI Listing
February 2019
2 Reads

[Acupuncture in the treatment of chronic fatigue syndrome based on "interaction of brain and kidney" in TCM: a randomized controlled trial].

Zhongguo Zhen Jiu 2019 Feb;39(2):123-7

Department of Tuina, Hangzhou Hospital of TCM, Hangzhou 310007, Zhejiang Province, China.

Objective: To observe the effects of acupuncture on the fatigue symptoms of chronic fatigue syndrome, the potential symptoms and cytokines on the base of the theory as "interaction of brain and kidney" and explore its clinical therapeutic effects and the potential mechanism.

Methods: A total of 68 patients were randomized into an observation group and a control group, 34 cases in each one. In the control group, oryzanol and vitamin B1 were prescribed for oral administration and the patients were required to have a proper rest and physical exercise. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2019.02.003DOI Listing
February 2019
4 Reads

Impact of Herbal Preparations on Outcomes of Highly Active Antiretroviral Therapy: A One-Year Prospective Cohort Study.

Chin J Integr Med 2019 Apr 2. Epub 2019 Apr 2.

Center for AIDS Research, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530011, China.

Objective: To investigate the impacts of two herbal preparations for human immunodeficiency virus/aquired immune deficiency syndrome (HIV/AIDS) patients, Shenling Fuzheng Capsule (, SLFZC) and Qingdu Capsule (, QDC), on the efficacy of highly active antiretroviral therapy (HAART).

Methods: HIV/AIDS patients met the criteria were all enrolled in a 1-year cohort study, in which patients receiving HAART alone were designated as Group A, those receiving HAART in combination with SLFZC were designated as Group B, and those receiving HAART in combination with QDC were designated as Group C, 100 cases in each group. The dose of SLFZC was 1. Read More

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http://dx.doi.org/10.1007/s11655-019-3156-xDOI Listing

A Timely Multidisciplinary Update on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Clin Ther 2019 Mar 30. Epub 2019 Mar 30.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA; Department of Internal Medicine, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA; Department of Psychiatry, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2019.03.004DOI Listing

B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

Ann Intern Med 2019 Apr 2. Epub 2019 Apr 2.

Haukeland University Hospital and University of Bergen, Bergen, Norway (O.D., O.M.).

Background: Previous phase 2 trials indicated benefit from B-lymphocyte depletion in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Objective: To evaluate the effect of the monoclonal anti-CD20 antibody rituximab versus placebo in patients with ME/CFS.

Design: Randomized, placebo-controlled, double-blind, multicenter trial. Read More

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http://dx.doi.org/10.7326/M18-1451DOI Listing
April 2019
2 Reads

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Trial Fails to Confirm Earlier Observations of Rituximab's Effectiveness.

Authors:
Peter C Rowe

Ann Intern Med 2019 Apr 2. Epub 2019 Apr 2.

Johns Hopkins University School of Medicine, Baltimore, Maryland (P.C.R.).

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http://dx.doi.org/10.7326/M19-0643DOI Listing

Rituximab for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Authors:

Ann Intern Med 2019 Apr 2. Epub 2019 Apr 2.

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http://dx.doi.org/10.7326/P19-0004DOI Listing

Methodological Strategies for Ecological Momentary Assessment to Evaluate Mood and Stress in Adult Patients Using Mobile Phones: Systematic Review.

JMIR Mhealth Uhealth 2019 Apr 1;7(4):e11215. Epub 2019 Apr 1.

Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, Republic of Korea.

Background: Ecological momentary assessment (EMA) has utility for measuring psychological properties in daily life. EMA has also allowed researchers to collect data on diverse experiences and symptoms from various subjects.

Objective: The aim of this study was to review methodological strategies and useful related information for EMA using mobile phones to capture changes of mood and stress in adult patients seeking health care. Read More

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http://dx.doi.org/10.2196/11215DOI Listing
April 2019
3 Reads

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome.

Clin Ther 2019 Mar 28. Epub 2019 Mar 28.

Institute for Neuro Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA; Miami Veterans Affairs Medical Center, Miami, FL, USA.

Purpose: The complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine and immune regulation, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-gonadal axis, and their interactive oversight of immune function. We propose that the persistence of ME/CFS may involve changes in the regulatory interactions across these physiological axes. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.03.002DOI Listing
March 2019
3 Reads

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome.

J Neuroinflammation 2019 Mar 30;16(1):67. Epub 2019 Mar 30.

Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underlying the association between pain and chronic stress using this rat model. Read More

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http://dx.doi.org/10.1186/s12974-019-1456-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441145PMC
March 2019
2 Reads

Transcultural, transdiagnostic, and concurrent validity of a revised Metacognitions about Symptoms Control Scale.

Clin Psychol Psychother 2019 Mar 29. Epub 2019 Mar 29.

Kingston University, Kingston upon Thames, UK.

Anxiety and depression add to the burden of Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and Type 1 Diabetes Mellitus (T1DM). Metacognitions play a role in this distress. The Metacognitions about Symptoms Control Scale (MaSCS) measures metacognitive beliefs regarding symptoms but has weaknesses. Read More

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http://dx.doi.org/10.1002/cpp.2367DOI Listing
March 2019
1 Read

Comments on Chronic Fatigue Syndrome.

Authors:
Richard I Shader

Clin Ther 2019 Mar 26. Epub 2019 Mar 26.

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http://dx.doi.org/10.1016/j.clinthera.2019.03.003DOI Listing

Cognitive-behavorial and graded exercise therapies for chronic fatigue (syndrome) are associated with lower levels of work/school attendance.

Authors:
Frank N M Twisk

J Behav Med 2019 Mar 28. Epub 2019 Mar 28.

ME-de-patiënten Foundation, Zonnedauw 15, 1906 HB, Limmen, The Netherlands.

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http://dx.doi.org/10.1007/s10865-019-00032-5DOI Listing

Relationship between different experimental measures of distorted symptom perception in functional syndrome patients.

Psychosom Med 2019 Mar 26. Epub 2019 Mar 26.

Health Psychology, Department of Psychology and Educational Sciences, University of Leuven, Belgium.

Objective: Patients with functional somatic syndromes (FSS) show reduced correspondence between induced physiological changes and self-reported symptoms in a rebreathing paradigm, as well as elevated symptoms unrelated to physiological changes after induction of negative affective states in an affective picture viewing paradigm. Detailed results of both paradigms separately were published elsewhere. The main goal of the current report is to describe the relationship between the responses to these two paradigms measuring distortions in symptom perception in a well-described sample of patients with fibromyalgia and/or chronic fatigue syndrome (CFS). Read More

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http://dx.doi.org/10.1097/PSY.0000000000000692DOI Listing
March 2019
1 Read

Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Authors:
Jonathan R Kerr

Front Pediatr 2019 13;7:59. Epub 2019 Mar 13.

Department of Microbiology, West Suffolk Hospital Foundation Trust, Bury St Edmunds, United Kingdom.

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a chronic multisystem disease characterized by a variety of symptoms, and exhibits various features of an autoimmune-like disease. Subtypes are well recognized but to date are difficult to identify objectively. The disease may be triggered by infection with a variety of micro-organisms, including Epstein-Barr virus (EBV). Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00059/
Publisher Site
http://dx.doi.org/10.3389/fped.2019.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424879PMC
March 2019
6 Reads

Fibromyalgia, Chronic Fatigue Syndrome, and Multiple Chemical Sensitivity: Illness Experiences.

Clin Nurs Res 2019 Mar 27:1054773819838679. Epub 2019 Mar 27.

1 Universidad Rey Juan Carlos, Madrid, Spain.

Fibromyalgia, chronic fatigue syndrome/myalgic encephalomyelitis, and multiple chemical sensitivity can be considered contested illnesses. The questioning of the status of these conditions as real diseases reduces feelings of legitimacy in those affected. The purpose of this study was to analyze subjectivity construction processes in people with these diseases. Read More

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http://dx.doi.org/10.1177/1054773819838679DOI Listing
March 2019
1 Read

Response: Sharpe, Goldsmith and Chalder fail to restore confidence in the PACE trial findings.

BMC Psychol 2019 Mar 26;7(1):19. Epub 2019 Mar 26.

Irish ME/CFS Association, Dublin, Republic of Ireland.

In a recent paper, we argued that the conclusions of the PACE trial of chronic fatigue syndrome are problematic because the pre-registered protocol was not adhered to. We showed that when the originally specific outcomes and analyses are used, the evidence for the effectiveness of CBT and graded exercise therapy is weak. In a companion paper to this article, Sharpe, Goldsmith and Chalder dismiss the concerns we raised and maintain that the original conclusions are robust. Read More

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https://bmcpsychology.biomedcentral.com/articles/10.1186/s40
Publisher Site
http://dx.doi.org/10.1186/s40359-019-0296-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434781PMC
March 2019
5 Reads

Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation.

Clin Ther 2019 Mar 22. Epub 2019 Mar 22.

School of Medicine, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain; Unidad Mixta CIPF-UCV, Centro de Investigación Príncipe Felipe, Valencia, Spain. Electronic address:

Purpose: Studies to determine epigenetic changes associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain scarce; however, current evidence clearly shows that methylation patterns of genomic DNA and noncoding RNA profiles of immune cells differ between patients and healthy subjects, suggesting an active role of these epigenetic mechanisms in the disease. The present study compares and contrasts the available ME/CFS epigenetic data in an effort to evidence overlapping pathways capable of explaining at least some of the dysfunctional immune parameters linked to this disease.

Methods: A systematic search of the literature evaluating the ME/CFS epigenome landscape was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.02.012DOI Listing

Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings.

PLoS One 2019 25;14(3):e0213724. Epub 2019 Mar 25.

Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom.

Introduction: A large body of evidence has established a pattern of altered functioning in the immune system, autonomic nervous system and hypothalamic pituitary adrenal axis in chronic fatigue syndrome. However, the relationship between components within and between these systems is unclear. In this paper we investigated the underlying network structure of the autonomic system in patients and controls, and a larger network comprising all three systems in patients alone. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213724PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433252PMC
March 2019
4 Reads

Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing.

PLoS One 2019 21;14(3):e0212193. Epub 2019 Mar 21.

Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America.

Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a syndrome of unknown etiology characterized by profound fatigue exacerbated by physical activity, also known as post-exertional malaise (PEM). Previously, we did not detect evidence of immune dysregulation or virus reactivation outside of PEM periods. Here we sought to determine whether cardiopulmonary exercise stress testing of ME/CFS patients could trigger such changes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428308PMC
March 2019
1 Read
3.234 Impact Factor

Acceptance and identity change: An interpretative phenomenological analysis of carers' experiences in myalgic encephalopathy/chronic fatigue syndrome.

J Health Psychol 2019 Mar 21:1359105319834678. Epub 2019 Mar 21.

University of Derby, UK.

Myalgic encephalopathy/chronic fatigue syndrome is a debilitating condition and many people rely heavily on family carers. This study explored the caring experiences of seven family carers. Four themes were established: relations with others, role and identity changes, coping with change and uncertainty, and information and support seeking. Read More

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http://dx.doi.org/10.1177/1359105319834678DOI Listing
March 2019
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Decreased Expression of the CD57 Molecule in T Lymphocytes of Patients with Chronic Fatigue Syndrome.

Authors:
P Espinosa J M Urra

Mol Neurobiol 2019 Mar 21. Epub 2019 Mar 21.

Immunology, Hospital General Universitario de Ciudad Real, 13005, Ciudad Real, Spain.

The chronic fatigue syndrome (CFS) is characterized by a prolonged incapacitating fatigue, headaches, sleep disturbances, and decreases in cognition, besides alterations in other physiological functions. At present, no specific biological markers have been described in this pathology. In the present study, we analyzed in lymphocytes the CD57 expression for the diagnosis of CFS, evaluating both the percentage of blood lymphocytes expressing CD57 and the average amount of the molecule expressed per cell. Read More

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http://dx.doi.org/10.1007/s12035-019-1549-7DOI Listing
March 2019
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Impact of Polypharmacy on Candidate Biomarker miRNomes for the Diagnosis of Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Striking Back on Treatments.

Pharmaceutics 2019 Mar 18;11(3). Epub 2019 Mar 18.

School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.

Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are diseases of unknown etiology presenting complex and often overlapping symptomatology. Despite promising advances on the study of miRNomes of these diseases, no validated molecular diagnostic biomarker yet exists. Since FM and ME/CFS patient treatments commonly include polypharmacy, it is of concern that biomarker miRNAs are masked by drug interactions. Read More

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http://dx.doi.org/10.3390/pharmaceutics11030126DOI Listing
March 2019
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The juvenile fibromyalgia syndrome (JFMS): a poorly defined disorder.

Acta Biomed 2019 Jan 23;90(1):134-148. Epub 2019 Jan 23.

Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy.

Juvenile fibromyalgia syndrome (JFMS) is a chronic condition characterized by symptoms of chronic diffuse musculoskeletal pain and multiple painful tender points on palpation. It is often accompanied by fatigue, disorders of sleep, chronic headaches, irritable bowel syndrome, and subjective soft tissue swelling. The complexity of the presenting clinical picture in JPFS has not been sufficiently defined in the literature. Read More

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http://dx.doi.org/10.23750/abm.v90i1.8141DOI Listing
January 2019
2 Reads

A systematic review of the association between fatigue and cognition in chronic noncommunicable diseases.

Chronic Illn 2019 Mar 18:1742395319836472. Epub 2019 Mar 18.

3 College of Nursing, University of Florida, FL, USA.

Objectives: Fatigue is one of the most common symptoms associated with chronic noncommunicable diseases, and it may also increase cognitive impairment. However, associations between fatigue and cognitive impairment in chronic illnesses remain unclear. Therefore, the purpose of this systematic review was to examine research that investigated associations between level of fatigue and cognitive status. Read More

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http://dx.doi.org/10.1177/1742395319836472DOI Listing
March 2019
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Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

Expert Rev Clin Immunol 2019 Mar 18. Epub 2019 Mar 18.

e Department of Otolaryngology , Beijing Electric Power Hospital , Beijing , China .

Introduction: An increasing number of patients present with multiple symptoms affecting many organs including the brain due to multiple mediators released by mast cells. These unique tissue immune cells are critical for allergic reactions triggered by IgE, but are also stimulated (not activated) by immune, drug, environmental, food, infectious, and stress triggers, leading to secretion of multiple mediators often without histamine and tryptase. The presentation, diagnosis and management of the spectrum of mast cell disorders is very confusing. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1596800DOI Listing