8,087 results match your criteria Chronic Fatigue Syndrome


Association between child maltreatment and central sensitivity syndromes: a systematic review protocol.

BMJ Open 2019 Feb 19;9(2):e025436. Epub 2019 Feb 19.

School of Nursing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction: A growing body of evidence is identifying the link between a history of child maltreatment and a variety of adverse health outcomes ultimately leading to significant social and healthcare burden. Initial work has identified a potential association between child maltreatment and the development of a selection of somatic and visceral central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, temporomandibular joint disorder, chronic lower back pain, chronic neck pain, chronic pelvic pain, interstitial cystitis, vulvodynia, chronic prostatitis, tension-type headache, migraine, myofascial pain syndrome, irritable bowel syndrome and restless legs syndrome.

Methods And Analysis: Primary electronic searches will be performed in the Embase, MEDLINE, PubMed, Scopus, PyscINFO, CINAHL and Cochrane Library databases and a number of Grey Literature sources including child protection and paediatric conference proceedings. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02543
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http://dx.doi.org/10.1136/bmjopen-2018-025436DOI Listing
February 2019
2 Reads

A role for corticosteroid-binding globulin variants in stress-related disorders.

Expert Rev Endocrinol Metab 2012 May;7(3):301-308

b Endocrine & Metabolic Unit, The University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.

Primary stress-related diseases such as chronic fatigue syndrome, fibromyalgia or chronic widespread pain have been associated with altered activity of the hypothalamic-pituitary-adrenal axis due to measured relative hyper- or hypo-cortisolism in basal or experimentally stimulated states. A hereditary risk to development of these diseases has been proposed. Corticosteroid-binding globulin (CBG), a plasma transport vehicle for cortisol, may play a more active role in the hypothalamic-pituitary-adrenal axis. Read More

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http://dx.doi.org/10.1586/eem.12.20DOI Listing

Postural orthostatic tachycardia syndrome (POTS): a common but unfamiliar syndrome.

Neth J Med 2019 Jan;77(1):3-9

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

Postural orthostatic tachycardia syndrome (POTS) is a condition in which a change from a supine to an upright position causes an abnormally large increase in heart rate which may be accompanied by a variety of physical complaints. We report two cases illustrating the heterogeneity of this syndrome. We give an update on the etiology of POTS, which is still poorly understood, and its overlap with other syndromes such as chronic fatigue syndrome. Read More

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January 2019

Health-related quality of life and costs in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

Health-related quality of life (HRQoL) has an increasing role in medical decision-making. This review of the literature aims to provide an overview on HRQoL, costs, and work disability in SS, a disease characterized by focal lymphocytic infiltration of exocrine glands with no therapeutics of proven immunomodulatory potential. HRQoL is markedly reduced in SS in multiple studies across many countries when compared with HRQoL in healthy controls. Read More

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http://dx.doi.org/10.1093/rheumatology/key370DOI Listing
February 2019
2 Reads

How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

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http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

Illness perceptions in adolescents with chronic fatigue syndrome and other physical health conditions: Application of the common sense model.

Clin Child Psychol Psychiatry 2019 Feb 15:1359104519829796. Epub 2019 Feb 15.

1 Department of Psychology, University of Bath, UK.

Background:: The common sense model (CSM) proposes that illness perceptions guide coping and illness management, which subsequently affects outcomes. Chronic fatigue syndrome (CFS) is associated with severe functional impairment. CFS is distinct from other physical health conditions in that individuals can experience high levels of uncertainty, stigma and disbelief from others. Read More

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http://dx.doi.org/10.1177/1359104519829796DOI Listing
February 2019
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Quality of life and its association with irritable bowel syndrome and fatigue ten years after giardiasis.

Neurogastroenterol Motil 2019 Feb 14:e13559. Epub 2019 Feb 14.

Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway.

Background: Gastroenteritis has been associated with complications such as irritable bowel syndrome (IBS) and chronic fatigue (CF). Little is known about the implications for quality of life (QoL) in this setting. The aims of this study were to evaluate the association between exposure to Giardia infection and QoL ten years after the infection, and how this related to IBS and CF. Read More

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http://dx.doi.org/10.1111/nmo.13559DOI Listing
February 2019
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Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Metab Brain Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Medicine, Imperial College London, Hammersmith Hospital, London, England, W12 0HS, UK.

A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with a consideration of the post-infection role of damage-associated molecular patterns and the development of chronic inflammatory, oxidative and nitrosative stress in genetically predisposed individuals. The consequences are detailed, including the role of increased intestinal permeability and the translocation of commensal antigens into the circulation, and the development of dysautonomia, neuroinflammation, and neurocognitive and neuroimaging abnormalities. Increasing levels of such stress and the switch to immune and metabolic downregulation are detailed next in relation to the advent of hypernitrosylation, impaired mitochondrial performance, immune suppression, cellular hibernation, endotoxin tolerance and sirtuin 1 activation. Read More

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http://dx.doi.org/10.1007/s11011-019-0388-6DOI Listing
February 2019

Fibromyalgia syndrome: under-, over- and misdiagnosis.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8.

Division of Rheumatology, McGill University Health Centre, Quebec, Canada and Alan Edwards Pain Management Unit, McGill University Health Centre, Quebec, Canada.

Fibromyalgia syndrome (FM) is an enigma. During the past three decades, with the gradual acceptance of the validity of FM, it is variously under-, over and misdiagnosed. Evidence-based interdisciplinary guidelines have suggested a comprehensive clinical assessment to avoid this diagnostic conundrum. Read More

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February 2019
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The Invisible Burden of Chronic Fatigue in the Community: a Narrative Review.

Curr Rheumatol Rep 2019 Feb 11;21(2). Epub 2019 Feb 11.

Department of Human Behaviour, School of Psychiatry, University of New South Wales, Level 1 30 Botany Street, UNSW, Sydney, NSW, 2052, Australia.

Purpose Of Review: Unexplained fatigue is commonly reported in the general population, with varying severity. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) sits at the extreme of the fatigue continuum, yet more individuals experience unexplained prolonged fatigue (1-6-month duration) or chronic fatigue (> 6 months) that, although debilitating, does not fulfil ME/CFS criteria. This review examines the empirical literature comparing symptoms for those with prolonged fatigue, chronic fatigue and ME/CFS. Read More

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http://dx.doi.org/10.1007/s11926-019-0804-2DOI Listing
February 2019

Authors' reply to Cognitive-behavioural therapy for chronic fatigue syndrome: neither efficacious nor safe.

Br J Psychiatry 2018 Dec;213(6):724

Department of Medical Psychology,VU University Medical Center,Amsterdam and Academic Medical Center (AMC),University of Amsterdam,the Netherlands.

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http://dx.doi.org/10.1192/bjp.2018.215DOI Listing
December 2018

Initiating Care of a Patient With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Authors:
Charles W Lapp

Front Pediatr 2018 23;6:415. Epub 2019 Jan 23.

Hunter-Hopkins Center PLLC, Charlotte, NC, United States.

This paper introduces the primary care physician to the unique and challenging aspects of initially diagnosing and managing a complex condition for which there are a plethora of symptoms, few physical findings, no known cause, and no specific treatments. While daunting, the rewards are many, and those who pursue an interest in ME/CFS find themselves at the forefront of medicine. Read More

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http://dx.doi.org/10.3389/fped.2018.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357921PMC
January 2019

Functional neuroimaging in patients presenting with somatoform disorders: A model for investigating persisting symptoms after tick bites and post-treatment Lyme disease syndrome?

Med Mal Infect 2019 Feb 5. Epub 2019 Feb 5.

Institut de neurosciences de la Timone UMR7289, campus santé, Aix-Marseille université, 13005 Marseille, France; Pôle de psychiatrie, Assistance publique-Hôpitaux de Marseille, 13005 Marseille, France; Fondation FondaMental, 13005 Créteil, France.

Approximately 10% of patients presenting with Lyme disease experience fatigue, musculoskeletal pain, concentration disorders, or short-term memory deficits in the six months following treatment. This entity has been defined as post-Lyme disease syndrome or post-treatment Lyme disease syndrome. The pathophysiology of this syndrome is unknown, but neither persistence of the bacterium nor effectiveness of antibiotics are currently reported in the literature. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.002DOI Listing
February 2019
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Ethical classification of ME/CFS in the United Kingdom.

Authors:
Diane O'Leary

Bioethics 2019 Feb 8. Epub 2019 Feb 8.

Rotman Institute of Philosophy, Western University, London, Ontario, Canada.

Few conditions have sparked as much controversy as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Professional consensus has long suggested that the condition should be classified as psychiatric, while patients and advocacy groups have insisted it is a serious biological disease that requires medical care and research to develop it. This longstanding debate shifted in 2015, when U. Read More

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http://dx.doi.org/10.1111/bioe.12559DOI Listing
February 2019

Post-bacterial infection chronic fatigue syndrome is not a latent infection.

Med Mal Infect 2019 Feb 2. Epub 2019 Feb 2.

Aix Marseille University, IRD, MEPHI, IHU, méditerranée infection, AP-HM, 13385 Marseille cedex 05, France.

Post-infectious chronic fatigue syndrome is a public health problem. Etiologies and physiopathological mechanisms are unknown. Some viruses are known to be involved in post-infectious chronic fatigue syndrome, but the role of bacterial infection is still questioned, especially in cases of post-treatment Lyme disease syndrome where subjective symptoms are regularly attributed to the presence of the dormant bacterium without scientific evidence. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.006DOI Listing
February 2019
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Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction.

PLoS One 2019 5;14(2):e0210394. Epub 2019 Feb 5.

Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom.

Objectives: To explore cognitive performance in chronic fatigue syndrome (CFS) examining two cohorts. To establish findings associated with CFS and those related to co-morbid depression or autonomic dysfunction.

Methods: Identification and recruitment of participants was identical in both phases, all CFS patients fulfilled Fukuda criteria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363139PMC
February 2019
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The Importance of Accurate Diagnosis of ME/CFS in Children and Adolescents: A Commentary.

Front Pediatr 2018 21;6:435. Epub 2019 Jan 21.

Division of Population Health, Health Services Research and Primary Care, Centre for Primary Care, University of Manchester, Manchester, United Kingdom.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic illness that causes a range of debilitating symptoms. While most research has focused on adults, the illness also presents in children and adolescents. Many physicians find it difficult to diagnose the illness. Read More

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http://dx.doi.org/10.3389/fped.2018.00435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348258PMC
January 2019

Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population.

Clin Rheumatol 2019 Jan 31. Epub 2019 Jan 31.

Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia.

Introduction: Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibromyalgia and CFS in a rheumatology clinic population. Read More

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http://dx.doi.org/10.1007/s10067-019-04447-yDOI Listing
January 2019
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Factors affecting quality of life in children and adolescents with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorders.

Am J Med Genet A 2019 Jan 31. Epub 2019 Jan 31.

Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Hypermobile Ehlers-Danlos syndrome (hEDS) is a hereditary disorder of connective tissue, often presenting with complex symptoms can include chronic pain, fatigue, and dysautonomia. Factors influencing functional disability in the pediatric hEDS population are incompletely studied. This study's aims were to assess factors that affect quality of life in children and adolescents with hEDS. Read More

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http://doi.wiley.com/10.1002/ajmg.a.61055
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http://dx.doi.org/10.1002/ajmg.a.61055DOI Listing
January 2019
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The Oslo University Hospital Pain Registry: development of a digital chronic pain registry and baseline data from 1,712 patients.

Scand J Pain 2019 Jan 30. Epub 2019 Jan 30.

Advisory Unit on Pain Management Health Region South-East, Oslo, Norway.

Background and aims Chronic pain is a leading cause to years lived with disability worldwide. However, few of the interventions used in pain medicine have proven efficacy, and evidence from the existing studies may not be valid for the general pain population. Therefore, it is of utmost need that we describe chronic pain conditions in their most relevant aspects, their various guises, as well as the real world outcomes of our clinical interventions. Read More

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http://dx.doi.org/10.1515/sjpain-2017-0160DOI Listing
January 2019
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Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

Front Neurol 2018 10;9:1033. Epub 2019 Jan 10.

Division of Neurotherapeutics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the label given to a syndrome that can include long-term flu-like symptoms, profound fatigue, trouble concentrating, and autonomic problems, all of which worsen after exertion. It is unclear how many individuals with this diagnosis are suffering from the same condition or have the same underlying pathophysiology, and the discovery of biomarkers would be clarifying. The name "myalgic encephalomyelitis" essentially means "muscle pain related to central nervous system inflammation" and many efforts to find diagnostic biomarkers have focused on one or more aspects of neuroinflammation, from periphery to brain. Read More

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http://dx.doi.org/10.3389/fneur.2018.01033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335565PMC
January 2019
2 Reads

Cytokine profiles in patients with Q fever fatigue syndrome.

J Infect 2019 Jan 23. Epub 2019 Jan 23.

Radboud Expertise Center for Q Fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Background: Q fever fatigue syndrome (QFS) is a state of prolonged fatigue following around 20% of acute Q fever cases. It is thought that chronic inflammation plays a role in its etiology. To test this hypothesis we measured circulating cytokines and the ex-vivo cytokine production in patients with QFS and compared with various control groups. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.006DOI Listing
January 2019
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Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study.

J Behav Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

This mixed-methods study investigated factors associated with fatigue, disability and school attendance in young people with severe CFS/ME. Participants' illness experiences were also explored. Questionnaires were completed at baseline (T1) and approximately 5 months later (T2). Read More

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http://dx.doi.org/10.1007/s10865-019-00010-xDOI Listing
January 2019
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Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning.

Front Pediatr 2018 8;6:412. Epub 2019 Jan 8.

Massachusetts ME/CFS & FM Association, Quincy, MA, United States.

Techniques of data mining and machine learning were applied to a large database of medical and facility claims from commercially insured patients to determine the prevalence, gender demographics, and costs for individuals with provider-assigned diagnosis codes for myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS). The frequency of diagnosis was 519-1,038/100,000 with the relative risk of females being diagnosed with ME or CFS compared to males 1.238 and 1. Read More

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http://dx.doi.org/10.3389/fped.2018.00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331450PMC
January 2019

The International Collaborative on Fatigue Following Infection (COFFI).

Fatigue 2018 19;6(2):106-121. Epub 2018 Jan 19.

Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilizing COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.

Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. Read More

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https://www.tandfonline.com/doi/full/10.1080/21641846.2018.1
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http://dx.doi.org/10.1080/21641846.2018.1426086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333416PMC
January 2018
5 Reads

Chronic fatigue syndrome in the emergency department.

Open Access Emerg Med 2019 11;11:15-28. Epub 2019 Jan 11.

Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC, USA,

Purpose: Chronic fatigue syndrome (CFS) is a debilitating disease characterized by fatigue, postexertional malaise, cognitive dysfunction, sleep disturbances, and widespread pain. A pilot, online survey was used to determine the common presentations of CFS patients in the emergency department (ED) and attitudes about their encounters.

Methods: The anonymous survey was created to score the severity of core CFS symptoms, reasons for going to the ED, and Likert scales to grade attitudes and impressions of care. Read More

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http://dx.doi.org/10.2147/OAEM.S176843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333158PMC
January 2019
1 Read

Relationship Between Exercise-induced Oxidative Stress Changes and Parasympathetic Activity in Chronic Fatigue Syndrome: An Observational Study in Patients and Healthy Subjects.

Clin Ther 2019 Jan 18. Epub 2019 Jan 18.

Pain in Motion International Research Group, Belgium(12); Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium; Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium.

Purpose: Oxidative stress has been proposed as a contributor to pain in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). During incremental exercise in patients with ME/CFS, oxidative stress enhances sooner and antioxidant response is delayed. We explored whether oxidative stress is associated with pain symptoms or pain changes following exercise, and the possible relationships between oxidative stress and parasympathetic vagal nerve activity in patients with ME/CFS versus healthy, inactive controls. Read More

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http://dx.doi.org/10.1016/j.clinthera.2018.12.012DOI Listing
January 2019
1 Read

Self-Compassion and Adherence in Five Medical Samples: the Role of Stress.

Mindfulness (N Y) 2019 10;10(1):46-54. Epub 2018 Apr 10.

2Department of Psychology, East Tennessee State University, Johnson City, TN USA.

Emerging evidence indicates self-compassion can be beneficial for medical populations and for medical adherence; yet, research to date has not fully examined the reasons for this association. This study examined the association of dispositional self-compassion to adherence across five medical samples and tested the extent to which perceived stress accounted for this association. Five medical samples (total  = 709), including fibromyalgia, chronic fatigue syndrome, and cancer patients, recruited from various sources, completed online surveys. Read More

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http://dx.doi.org/10.1007/s12671-018-0945-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320740PMC
April 2018
1 Read

Internet-based self-diagnosis of Lyme disease caused death in a young woman with systemic lupus erythematosus.

Joint Bone Spine 2019 Jan 17. Epub 2019 Jan 17.

Department of Immunology, 2ndFaculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.

In the majority of cases, Lyme disease responds well to antibiotic treatment. Nevertheless, some patients may suffer from chronic nonspecific symptoms such as musculoskeletal pain and fatigue, termed as a post-treatment Lyme disease syndrome (PTLDS). Proper understanding and management of PTLDS may prevent from the incorrect diagnosis of patients with autoimmune, neuromuscular or other somatic disorders, where identical symptoms are equally prevalent. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.12.011DOI Listing
January 2019
1 Read

Effects of a health education program on cytokines and cortisol levels in fibromyalgia patients: a randomized controlled trial.

Adv Rheumatol 2018 Aug 3;58(1):21. Epub 2018 Aug 3.

Departamento de Morfologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais (UFMG), Avenida Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil.

Background: Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain associated to other symptoms, such as: fatigue, anxiety, depression and sleep disorders. Health education programs (HEP) have emerged as good non-pharmacological strategies to treat it. However, it is still not clear if the benefits are only subjective, or it has also objective impacts on immune and or neuroendocrine systems. Read More

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https://advancesinrheumatology.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s42358-018-0022-zDOI Listing
August 2018
5 Reads

Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.

J Clin Densitom 2018 Dec 21. Epub 2018 Dec 21.

Center for Metabolic Bone Diseases, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium. Electronic address:

Background: Hypophosphatasia (HPP) is a rare metabolic bone disorder caused by mutations in the alkaline phosphatase (ALPL) gene, and characterized by low circulating alkaline phosphatase (ALP) levels and bone, muscle, dental and systemic manifestations. In this case series we investigate the clinical spectrum, genetic and biochemical profile of adult HPP patients from the University Hospitals Leuven, Belgium.

Methodology: Adults with HPP were identified through medical record review. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950183024
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http://dx.doi.org/10.1016/j.jocd.2018.12.006DOI Listing
December 2018
3 Reads

Long-term effect of cognitive behavioural therapy and doxycycline treatment for patients with Q fever fatigue syndrome: One-year follow-up of the Qure study.

J Psychosom Res 2019 Jan 12;116:62-67. Epub 2018 Nov 12.

Expert Center for Chronic Fatigue, Department of Medical Psychology, VU University Medical Centre, Amsterdam, The Netherlands; Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Background: Previously, we reported a randomized placebo-controlled trial, the Qure study, showing that cognitive behavioural therapy (CBT), and not doxycycline, was significantly more effective than placebo in reducing fatigue severity in Q fever fatigue syndrome (QFS) patients. This follow-up study evaluates the long-term effect of these treatment regimens, 1 year after completion of the original trial.

Methods: All patients who completed the Qure study, CBT (n = 50), doxycycline (n = 52), and placebo (n = 52), were included in this follow-up study. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2018.11.007DOI Listing
January 2019
2 Reads

Validation of Chronic Liver Disease Questionnaire for Non-Alcoholic Steatohepatitis in Patients with Biopsy-Proven Non-alcoholic Steatohepatitis.

Clin Gastroenterol Hepatol 2019 Jan 10. Epub 2019 Jan 10.

Center For Liver Disease, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, United States; Center for Outcomes Research in Liver Diseases, Washington, DC, USA.

Background & Aims: The chronic liver disease questionnaire for non-alcoholic steatohepatitis (CLDQ-NASH) was developed in a systematic manner for assessment of patient-reported outcomes. This instrument collects data on 36 items grouped into 6 domains: abdominal symptoms, activity/energy, emotional health, fatigue, systemic symptoms, and worry. We aimed to validate CLDQ-NASH in a large group of patients with NASH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193002
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http://dx.doi.org/10.1016/j.cgh.2019.01.001DOI Listing
January 2019
7 Reads

Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study.

Health Expect 2019 Jan 10. Epub 2019 Jan 10.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

Background: The Clinical Understanding and Research Excellence in ME/CFS group (CureME) at the London School of Hygiene & Tropical Medicine has supported and undertaken studies in immunology, genetics, virology, clinical medicine, epidemiology and disability. It established the UK ME/CFS Biobank (UKMEB), which stores data and samples from three groups: participants with ME/CFS, Multiple Sclerosis (MS) and healthy controls. Patient and public involvement have played a central role from its inception. Read More

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http://dx.doi.org/10.1111/hex.12857DOI Listing
January 2019

"It's not one size fits all"; the use of videoconferencing for delivering therapy in a Specialist Paediatric Chronic Fatigue Service.

Internet Interv 2019 Mar 23;15:43-51. Epub 2018 Dec 23.

Bristol Medical School, University of Bristol, UK.

Background: There are few specialist paediatric Chronic Fatigue Syndrome (CFS/ME) services in the UK. Therefore, the distance some families have to travel to reach these services can be a barrier to accessing evidence-based treatment. Videoconferencing technology such as Skype provides a means of delivering sessions remotely. Read More

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http://dx.doi.org/10.1016/j.invent.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312867PMC
March 2019
2 Reads

A 4-Day Mindfulness-Based Cognitive Behavioral Intervention Program for CFS/ME. An Open Study, With 1-Year Follow-Up.

Front Psychiatry 2018 20;9:720. Epub 2018 Dec 20.

Department of Mental Health, Haukeland University Hospital, Bergen, Norway.

Chronic Fatigue Syndrome/Myalgic Encephalopathy (CFS/ME) is an incapacitating illness in which single treatment interventions seem to have variable effects. Based on an earlier study we have conducted a new study with a concentrated intervention program. The aims of this study were to: (1) explore the clinical course for patients with CFS/ME who participated in a treatment program delivered during four consecutive days, and (2) evaluate their satisfaction with this program. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306445PMC
December 2018
2 Reads

Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy.

Brain Imaging Behav 2019 Jan 7. Epub 2019 Jan 7.

Department of Psychology, The University of Alabama at Birmingham, 1720 2nd Ave S, Birmingham, AL, 35294, USA.

Previous neuroimaging studies have detected markers of neuroinflammation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Magnetic Resonance Spectroscopy (MRS) is suitable for measuring brain metabolites linked to inflammation, but has only been applied to discrete regions of interest in ME/CFS. We extended the MRS analysis of ME/CFS by capturing multi-voxel information across the entire brain. Read More

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http://dx.doi.org/10.1007/s11682-018-0029-4DOI Listing
January 2019
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Adolescent's descriptions of fatigue, fluctuation and payback in chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): interviews with adolescents and parents.

BMJ Paediatr Open 2018 4;2(1):e000281. Epub 2018 Dec 4.

Centre for Academic Child Health, University of Bristol, Bristol, UK.

Objective: As part of a larger qualitative study to explore outcomes important in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) and what improvements in fatigue and disability are key, interviews were undertaken with adolescents and their parents. This paper focuses on their descriptions of fatigue, fluctuation of symptoms and payback.

Design And Setting: Semistructured qualitative interviews were undertaken between December 2014 and February 2015. Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307594PMC
December 2018

Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem.

Int J Environ Res Public Health 2019 Jan 3;16(1). Epub 2019 Jan 3.

School of Health Sciences and Social Work, University of Portsmouth, Portsmouth P01 2DT, UK.

An estimated 25%⁻32% of veterans of the 1991 Gulf War continue to experience multiple unexplained health problems known as Gulf War Illness (GWI). GWI encompasses chronic pain, musculoskeletal weakness, headache, fatigue, cognitive deficits, alterations in mood, and numerous multi-system complaints. Most potential exposures implicated in GWI were not well documented but included varying levels of several neurotoxicants as well as the anticholinergic drug pyridostigmine bromide (PB), which was routinely taken as prophylaxis against the nerve agent soman. Read More

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http://dx.doi.org/10.3390/ijerph16010111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339135PMC
January 2019
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Depression as a Mediator of Chronic Fatigue and Post-Traumatic Stress Symptoms in Middle East Respiratory Syndrome Survivors.

Psychiatry Investig 2019 Jan 7;16(1):59-64. Epub 2019 Jan 7.

Department of Psychiatry, National Medical Center, Seoul, Republic of Korea.

Objective: The relationship among chronic fatigue, depressive symptoms, and post-traumatic stress symptoms (PTSSs) among Middle East respiratory syndrome (MERS) survivors is poorly understood.

Methods: Of 148 survivors who consented to be registered and underwent assessments at 12 months (T1) and 18 months (T2) after the MERS outbreak, 72 (48.65%) were evaluated for chronic fatigue, depressive symptoms, and PTSSs based on the Impact of Event ScaleRevised (IES-R), the Patient Health Questionnaire-9 (PHQ-9), and the Fatigue Severity Scale (FSS). Read More

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http://dx.doi.org/10.30773/pi.2018.10.22.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354037PMC
January 2019
1 Read

Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers.

Psychiatry Investig 2019 Jan 7;16(1):71-79. Epub 2019 Jan 7.

Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Objective: The present study compared cancer-related fatigue (CRF) and chronic fatigue syndrome (CFS) using multidimensional measurements with the aim of better understanding characteristics and exploring markers of two similar fatigue syndromes.

Methods: Twenty-five patients with CRF and twenty patients with CFS completed questionnaires, including the Fatigue Severity Scale (FSS), Hospital Anxiety Depression Scale (HADS), Perceived Stress Scale (PSS), and Pittsburgh Sleep Quality Index (PSQI). Additionally, levels of high sensitivity C-reactive protein (hs-CRP), heart rate variability (HRV), and electroencephalography (EEG) were obtained. Read More

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http://dx.doi.org/10.30773/pi.2018.10.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354035PMC
January 2019

Supervised walking improves cardiorespiratory fitness, exercise tolerance, and fatigue in women with primary Sjögren's syndrome: a randomized-controlled trial.

Rheumatol Int 2019 Feb 2;39(2):227-238. Epub 2019 Jan 2.

Department of Rheumatology, Universidade Federal de São Paulo-Escola Paulista de Medicina, Rua Botucatu, 740, São Paulo, SP, 04023-900, Brazil.

Objective: The aim of this study was to evaluate the safety and effectiveness of a supervised walking program in women with primary Sjögren's syndrome (pSS).

Methods: Forty-five sedentary women fulfilling the American European Consensus Criteria for pSS were randomized to a training group (TG, n = 23) or control group (CG, n = 22). Patients in the TG were submitted to supervise walking three times a week for 16 weeks. Read More

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http://dx.doi.org/10.1007/s00296-018-4213-zDOI Listing
February 2019
3 Reads

Corrigendum to "Differential effects of childhood trauma subtypes on fatigue and physical functioning in chronic fatigue syndrome" [Comprehensive Psychiatry 78 (2017) 76-82].

Compr Psychiatry 2019 Feb 27;89:78-79. Epub 2018 Dec 27.

University Psychiatric Department, Campus Antwerp University Hospital (UZA), Antwerp (Edegem), Belgium; Collaborative Antwerp Psychiatric Research Institute (CAPRI), Faculty of Medicine and Health Sciences, University of Antwerp (UA), Antwerp, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S0010440X183021
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http://dx.doi.org/10.1016/j.comppsych.2018.12.011DOI Listing
February 2019
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Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome.

Clin Hemorheol Microcirc 2018 Dec 28. Epub 2018 Dec 28.

Department of Chemical and Materials Engineering, San José State University, San José, CA, USA.

Background: Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disease. Amongst others symptoms, the disease is associated with profound fatigue, cognitive dysfunction, sleep abnormalities, and other symptoms that are made worse by physical or mental exertion. While the etiology of the disease is still debated, evidence suggests oxidative damage to immune and hematological systems as one of the pathophysiological mechanisms of the disease. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/CH-180469DOI Listing
December 2018
16 Reads
2.242 Impact Factor

Myalgic Encephalomyelitis or What? The International Consensus Criteria.

Authors:
Frank Twisk

Diagnostics (Basel) 2018 Dec 20;9(1). Epub 2018 Dec 20.

ME-de-Patiënten Foundation, Zonnedauw 15, 1906 HB Limmen, The Netherlands.

Myalgic encephalomyelitis (ME) is a neuromuscular disease with two distinctive types of symptoms (muscle fatigability or prolonged muscle weakness after minor exertion and symptoms related to neurological disturbance, especially of sensory, cognitive, and autonomic functions) and variable involvement of other bodily systems. Chronic fatigue syndrome (CFS), introduced in 1988 and re-specified in 1994, is defined as (unexplained) chronic fatigue accompanied by at least four out of eight listed (ill-defined) symptoms. Although ME and CFS are two distinct clinical entities (with partial overlap), CFS overshadowed ME for decades. Read More

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http://www.mdpi.com/2075-4418/9/1/1
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http://dx.doi.org/10.3390/diagnostics9010001DOI Listing
December 2018
8 Reads

Stress, inflammation and natural treatments.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6):1345-1347

Department of Biomedical Sciences, University of Greenwich, UK - *present address: BiomedAdvice, LLC, Boston, MA, USA.

Stress and inflammation have become the curses of our times and are the main pathogenetic factors in multiple diseases that are often comorbid and include allergies and asthma, eczema and psoriasis, fibromyalgia syndrome, mast cell activation syndrome, irritable bowel syndrome, myalgic encephalomyelitis/chronic fatigue syndrome and autism spectrum disorder (ASD). Unfortunately, there are no effective drugs. Cross-talk between mast cells and microglia in the hypothalamus and amygdala could explain stress-induced inflammation. Read More

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December 2018
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The link between idiopathic intracranial hypertension, fibromyalgia, and chronic fatigue syndrome: exploration of a shared pathophysiology.

J Pain Res 2018 10;11:3129-3140. Epub 2018 Dec 10.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Musculoskeletal Rehabilitation Research Unit, University of Leuven, Leuven, Belgium,

Purpose: Idiopathic intracranial hypertension (IICH) is a condition characterized by raised intracranial pressure (ICP), and its diagnosis is established when the opening pressure measured during a lumbar puncture is elevated >20 cm HO in nonobese patients or >25 cm HO in obese patients. Papilledema is caused by forced filling of the optic nerve sheath with cerebrospinal fluid (CSF). Other common but underappreciated symptoms of IICH are neck pain, back pain, and radicular pain in the arms and legs resulting from associated increased spinal pressure and forced filling of the spinal nerves with CSF. Read More

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https://www.dovepress.com/the-link-between-idiopathic-intrac
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http://dx.doi.org/10.2147/JPR.S186878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292399PMC
December 2018
9 Reads

A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis.

Syst Rev 2018 Dec 20;7(1):241. Epub 2018 Dec 20.

National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia.

Background: Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation. Read More

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http://dx.doi.org/10.1186/s13643-018-0909-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302292PMC
December 2018

Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome.

Psychoneuroendocrinology 2019 Feb 17;100:276-285. Epub 2018 Dec 17.

Dept. of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address:

The role of immune or infective triggers in the pathogenesis of Chronic Fatigue Syndrome (CFS) is not yet fully understood. Barriers to obtaining immune measures at baseline (i.e. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350004PMC
February 2019
2 Reads

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity.

Front Pediatr 2018 4;6:373. Epub 2018 Dec 4.

Autoimmunity Research Foundation, Thousand Oaks, CA, United States.

The illness ME/CFS has been repeatedly tied to infectious agents such as Epstein Barr Virus. Expanding research on the human microbiome now allows ME/CFS-associated pathogens to be studied as interacting members of human microbiome communities. Humans harbor these vast ecosystems of bacteria, viruses and fungi in nearly all tissue and blood. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00373/
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http://dx.doi.org/10.3389/fped.2018.00373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288442PMC
December 2018
16 Reads