1,258,928 results match your criteria Chronic Fatigue Syndrome


[Recommendations from a panel of experts on the usefulness of fidaxomicin for the treatment of infections caused by Clostridium difficile].

Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.

Benito Almirante, Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron Passeig de la Vall d'Hebron, 119-129 - 08035 Barcelona, Spain.

Objective: Clostridium difficile infections have a high recurrence rate, which can complicate the prognosis of affected patients. It is therefore important to establish an early detection and an appropriate therapeutic strategy. The objective of this manuscript was to gather the opinion of an expert group about the predictive factors of poor progression, as well as when to use fidaxomicin in different groups of high-risk patients. Read More

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December 2018

Cognitive training benefit depends on brain injury location in adolescents with traumatic brain injury: a pilot study.

Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.

School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.

Background: Executive dysfunctioning after pediatric traumatic brain injury (TBI) has been linked to poor outcomes in school performance, social functioning and employment. The credibility of training-induced cognitive enhancement in TBI is threatened by its limited proof of benefit in executive skills of daily living.

Aim: Our primary aim was to investigate if cognitive intervention for improving impairments in executive functions in the chronic stage of traumatic brain injury is effective during adolescence. Read More

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December 2018

A 9-months multidisciplinary rehabilitation protocol based on early post-operative mobilization following a chronic-degenerative patellar tendon rupture in a professional soccer player: a case report.

Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Background: Isolated patellar tendon rupture (PTR) is the final stage of a long-standing tendon chronic degeneration. PTR requires immediate repair in order to avoid important muscle retraction and tendon fibrosis. The aim was to describe the effects of a rehabilitation protocol after chronic-degenerative PTR on subjective functional outcomes, knee range of motion (ROM), size, and strength in a professional football player. Read More

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December 2018

Application of Daphnia magna for Nanoecotoxicity Study.

Methods Mol Biol 2019 ;1894:345-352

Key Laboratory of Occupational Safety and Health, Beijing Municipal Institute of Labour Protection, Beijing, People's Republic of China.

Daphnia magna (D. magna), an aquatic invertebrate, is the most commonly used test organism in ecotoxicological studies on manufactured nanomaterials (MNs). Although standard protocols for undertaking acute and chronic toxicity tests of dissolved chemicals with D. Read More

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January 2019

Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP).

Surg Endosc 2018 Dec 13. Epub 2018 Dec 13.

Department of Electrical and Computer Engineering, Texas A&M University, 309D Wisenbaker Engineering Research Center, College Station, TX, 77843-3128, USA.

Background: Complications of ventral hernia repair (VHR) may be investigated by computed tomography or ultrasound (US) but neither modality gives a quantifiable metric of repair quality short of identifying hernia recurrence. Platelet-rich plasma (PRP), a growth factor-rich autologous blood product, has been shown to improve incorporation of native tissue with bioprosthetics. In this study, we investigate the effect of PRP on the incorporation and mechanical integrity of a non-crosslinked porcine acellular dermal matrix (pADM) in a rodent model of VHR and the correlative ability of ultrasound shear wave elastography (US-SWE) to assess repair quality. Read More

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December 2018

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

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December 2018
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Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice.

Neurochem Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, Tianjin, 300121, China.

Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Read More

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December 2018

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.

Geroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.

Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More

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December 2018

Increasing trends in in situ breast cancer incidence in a region with no population-based mammographic screening program: results from Zurich, Switzerland 2003-2014.

J Cancer Res Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

Division of Chronic Disease Epidemiology, Institute for Epidemiology, Biostatistics and Prevention, University of Zurich, Hirschengraben 82, 8001, Zurich, Switzerland.

Purpose: Increase in in situ breast cancer (BCIS) incidence has been reported across Europe and the USA. However, little is known about the trends in BCIS incidence in regions without population-based mammographic screening programs. We set out to investigate these trends in Zurich, Switzerland, where only opportunistic mammographic screening exists. Read More

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December 2018

Interferon-α-induced retinopathy in chronic hepatitis C treatment: summary, considerations, and recommendations.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-α with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-α is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. Read More

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December 2018

Laparoscopic Roux-En-Y Fistulo-Jejunostomy, a Preferred Technique after Failure of Endoscopic and Radiologic Management of Fistula Post Sleeve Gastrectomy.

Obes Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Digestive Surgery, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint-Antoine, 06200, Nice, France.

Background: Laparoscopic sleeve gastrectomy represents the most performed bariatric procedure in France. Staple line leak is the major short-term complication of the procedure. Patients with persistent fistula after sleeve gastrectomy, after failure of endoscopic and radiological treatment, are candidates for salvage surgery. Read More

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December 2018

Correction to: Impaired endogenous nighttime melatonin secretion relates to intrarenal renin-angiotensin system activation and renal damage in patients with chronic kidney disease.

Clin Exp Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Internal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

In the original publication, an error occurred in Table 4 (B), under Nighttime group. The value of "Nighttime Log U-AGT/Cr" for model 3 (under R = 0.68) was incorrectly published as 0. Read More

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December 2018

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.

Methods: We performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) approach. Read More

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December 2018

Increase in cetuximab-induced skin rash and hypomagnesemia in patients receiving concomitant treatment with proton pump inhibitors (PPIs): a possible drug interaction?

Cancer Chemother Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Center for Malignant Diseases, Emek Medical Center, 21 Yitzhak Rabin Blvd, 1834111, Afula, Israel.

Introduction: In a previous study, we found that co-administration of proton pump inhibitors (PPIs) with cetuximab was associated with increased skin toxicity. Both these drugs can induce hypomagnesemia. The aim of this study was to retrospectively explore the possible influence of PPI drugs on cetuximab skin toxicity and the potential synergistic effect of hypomagnesemia. Read More

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December 2018

Utility of the claw sign in spine magnetic nuclear resonance with diffusion to differentiate Modic type I changes for degenerative disease versus infection.

J Spine Surg 2018 Sep;4(3):616-623

Neuroradiology Service, Central Military Hospital, Bogotá DC, Colombia.

Background: In 1988, Modic and his colleagues described changes in the subchondral bone marrow of the vertebral plates in patients with degenerative disease or other pathologies, which were observed in the nuclear magnetic resonance (NMR) of the spine and were subdivided into three patterns of signal changes, called Modic type I, Modic type II and Modic type III. The main differential diagnosis of the Modic I changes of the vertebral plates due to degenerative disease in spine NMR, is infection in its early stages. In their study in 2014, Patel and collaborators, using a protocol and the concept of diffusion in spine MRI, were able to demonstrate that by means of the "claw sing", a degenerative disease with Modic type I changes, can be differentiated from an infection in early stages. Read More

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September 2018

Chronic obstructive pulmonary disease is an independent predictor for 30-day readmissions following 1- to 2-level posterior lumbar fusions.

J Spine Surg 2018 Sep;4(3):553-559

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality worldwide. Past literature has demonstrated that patients with COPD are at an increased risk of post-operative complications. We assessed the impact of COPD on 30-day outcomes following a 1- to 2-level posterior lumbar fusion (PLF). Read More

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September 2018

Presence of both anti-contactin 1 and anti-neurofascin 140 antibodies in a case of chronic inflammatory demyelinating polyneuropathy.

eNeurologicalSci 2018 Dec 22;13:38-39. Epub 2018 Nov 22.

Department of Neurology, University of Florida, Gainesville, FL 32610, United States.

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired disorder of peripheral nerves and nerve roots. Its cause is unknown, but recently antibodies to nodal and paranodal proteins have been discovered in a small subset of CIDP patients. These contactin and neurofascin-related immune-mediated neuropathies are thought to be variants of CIDP and often respond suboptimally to standard therapy. Read More

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December 2018

Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use.

Cannabis Cannabinoid Res 2018 10;3(1):242-251. Epub 2018 Dec 10.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California.

Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful to the developing adolescent brain compared with adult-onset usage. However, the long-term effects of heavy, adolescent CB use on brain structure and cognitive performance in late-life remain unknown. Read More

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December 2018
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Risk Factors for Short- and Long-Term Outcomes in Children With STEC-HUS/D HUS: A Single-Center Experience.

Glob Pediatr Health 2018 4;5:2333794X18816920. Epub 2018 Dec 4.

The Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

. Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. . Read More

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December 2018

Economic Evaluation of an Integrated Health and Social Care Program for Heart Failure Through 2 Different Modeling Techniques.

Health Serv Res Manag Epidemiol 2018 Jan-Dec;5:2333392818795795. Epub 2018 Dec 3.

AP-OSI Research Unit, Alto Deba Integrated Healthcare Organisation, Mondragón, Spain.

Introduction: An integrated health and social care program for patients with heart failure (HF) was implemented at the Friuli-Venezia Giulia deployment site as part of the SmartCare European project. The objective of this study was to validate 2 different decision modeling techniques used to perform the economic evaluation.

Methods: Data were collected during the SmartCare project which enrolled 108 patients with HF and followed for more than 6 months. Read More

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December 2018

The Role of Anticoagulation in Treating Portal Hypertension.

Curr Hepatol Rep 2018 18;17(3):200-208. Epub 2018 Jun 18.

1Division of Gastroenterology, Azienda Ospedaliero-Universitaria di Modena and University of Modena and Reggio Emilia, Modena, Italy.

Purpose Of Review: To revise experimental and clinical data supporting a less traditional role of anticoagulation for treating portal hypertension in patients with cirrhosis.

Recent Findings: Portal hypertension is the main driver of complications such as ascites, variceal hemorrhage, and hepatic encephalopathy, with inflammation as a key component. The traditional view of cirrhosis as a pro-hemorrhagic condition has recently changed, prothrombotic complications being recognized as frequently as the hemorrhagic ones. Read More

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Is Use of Bone Cement for Treatment of Second Metatarsal Stress Fractures Safe? A Case Report.

Cureus 2018 Oct 9;10(10):e3436. Epub 2018 Oct 9.

Orthopaedics, University of Alabama at Birmingham, Birmingham, USA.

Metatarsal stress fractures are common injuries of the foot and can be a source of chronic pain without appropriate management. Conservative management is first line, but surgery may be indicated in athletes, cases of nonunion, and fractures of the fifth metatarsal. We report a case of a 34-year-old female who presented to clinic for intractable pain of the left foot secondary to a stress fracture of the left second metatarsal, which had been previously treated with injectable acrylic bone cement. Read More

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October 2018
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Fatigued Patients with Chronic Liver Disease Have Subtle Aberrations of Sleep, Melatonin and Cortisol Circadian Rhythms.

Fatigue 2018 3;6(1):5-19. Epub 2017 Dec 3.

Liver & Energy Metabolism Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Aims: We sought to examine whether disturbances in central and peripheral circadian rhythms were related to the experience of fatigue in patients with chronic liver disease (CLD).

Methods: Fatigued and non-fatigued patients with compensated CLD were enrolled in a prospective pilot study. Patients underwent a one week evaluation of free-living sleep and physical activity patterns, followed by a 24-hour admission, during which they underwent serial blood sampling, polysomnography, a 6-minute walk test and continuous core temperature measurements under standardized conditions. Read More

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December 2017
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lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression.

Oncoimmunology 2019 16;8(1):e1518628. Epub 2018 Oct 16.

National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai China.

Hepatocellular carcinoma (HCC) is one type of cancers whose carcinogenesis and progression are closely related to chronic inflammation. Identifying the molecular mechanisms for inflammation-related HCC progression will contribute to improve the efficacy of current therapeutics for HCC patients. Many kinds of epigenetic factors, including long non-coding RNAs (lncRNAs), have been discovered to be important in HCC growth and metastasis. Read More

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October 2018

Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation, proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model.

Oncoimmunology 2019 11;8(1):e1512455. Epub 2018 Oct 11.

Department of Pediatrics, New York Medical College, Valhalla, NY, USA.

Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in part regulates normal B-cell development. Ibrutinib, a selective and irreversible BTK inhibitor, has been efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia, and marginal zone lymphoma. Read More

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October 2018
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Inhibition of osteoblast differentiation by ritonavir.

Biomed Rep 2018 Dec 2;9(6):491-496. Epub 2018 Oct 2.

Department of Internal Medicine, Teikyo University, Tokyo 173-8606, Japan.

Osteoporosis is one of the chronic complications seen in human immunodeficiency virus (HIV)-infected patients, and affects patients at high prevalence. The causes of osteoporosis in HIV-infected patients are multiple, and include chronic HIV infection, living habits such as smoking and alcohol consumption, and antiretroviral drug use. Among antiretroviral drugs, protease inhibitors have been reported to be associated with osteoporosis. Read More

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December 2018

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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November 2018
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The application of updating PIM-Taiwan criteria in clinic-visiting older patients with polypharmacy.

Ther Adv Drug Saf 2018 Dec 15;9(12):699-709. Epub 2018 Oct 15.

Department of Geriatrics and Gerontology, National Taiwan University Hospital, Zhongshan South Road, Zhongzheng District, Taipei, 100, Taiwan.

Background: PIM-Taiwan criteria were first established in 2010 for potentially inappropriate medications (PIMs). Currently, updating of PIM criteria is mandatory because of newly established evidence and newly developed medications. This study aims to evaluate the prevalence of PIM based on country-specific PIM criteria and factors associated with PIM use by applying 2010 version and newly updating PIM-Taiwan criteria in a cohort with polypharmacy. Read More

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December 2018

Deprescribing conversations: a closer look at prescriber-patient communication.

Ther Adv Drug Saf 2018 Dec 20;9(12):687-698. Epub 2018 Oct 20.

Facultés de Médecine et de Pharmacie, Université de MontréalResearch Center of Institut Universitaire de Gériatrie de Montréal, Québec, Canada.

Background: Little is known about the initiation, style and content of patient and healthcare provider communication around deprescribing. We report the findings from a content analysis of audio-recorded discussions of proton pump inhibitor (PPI) and benzodiazepine deprescribing in primary care.

Methods: Participants were healthcare providers ( = 13) from primary care practices ( = 3) and patients aged ⩾65 ( = 24) who were chronic users of PPIs or benzodiazepines. Read More

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December 2018

Common mental disorder among family carers of demented older people in Brazil.

Dement Neuropsychol 2018 Oct-Dec;12(4):402-407

MD,PhD, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil.

Objective: Population aging is a global phenomenon associated with a rising prevalence of chronic degenerative diseases such as dementia. Dementia poses a challenge not only for patients but also their family caregivers who, in exercising this role, are at higher risk of mental illness. The present study investigated the prevalence of common mental disorders (CMD) in family caregivers of demented elderly seen at a geriatric outpatient clinic of a Brazilian teaching hospital. Read More

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December 2018

The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

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November 2018

Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury.

Oncotarget 2018 Nov 16;9(90):36185-36201. Epub 2018 Nov 16.

Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.

Renal ischemia/reperfusion (I/R) injury occurs in patients undergoing renal transplantation and with acute kidney injury and is responsible for the development of chronic allograft dysfunction as characterized by parenchymal alteration and fibrosis. Heparanase (HPSE), an endoglycosidase that regulates EMT and macrophage polarization, is an active player in the biological response triggered by ischemia/reperfusion (I/R) injury. I/R was induced by clamping left renal artery for 30 min in wt C57BL/6J mice. Read More

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November 2018

Correlative analysis of the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection.

Oncol Lett 2018 Dec 28;16(6):7189-7194. Epub 2018 Sep 28.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200127, P.R. China.

This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. Read More

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December 2018

Identification of a role for serum aldo-keto reductase family 1 member B10 in early detection of hepatocellular carcinoma.

Oncol Lett 2018 Dec 3;16(6):7123-7130. Epub 2018 Oct 3.

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China.

Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. Read More

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December 2018

Neuroinflammation in mouse models of Alzheimer's disease.

Clin Exp Neuroimmunol 2018 Nov 23;9(4):211-218. Epub 2018 Sep 23.

RIKEN Center for Brain Science Laboratory for Proteolytic Neuroscience Wako Japan.

Alzheimer's disease (AD) is the most common type of neurocognitive disorder. Although both amyloid β peptide deposition and neurofibrillary tangle formation in the AD brain have been established as pathological hallmarks of the disease, many other factors contribute in a complex manner to the pathogenesis of AD before clinical symptoms of the disease become apparent. Longitudinal pathophysiological processes cause patients' brains to exist in a state of chronic neuroinflammation, with glial cells acting as key regulators of the neuroinflammatory state. Read More

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November 2018

Beta 1, Beta 2 and Beta 3 Adrenergic Receptor Gene Polymorphisms in a Southeastern European Population.

Front Genet 2018 28;9:560. Epub 2018 Nov 28.

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece.

Genetic polymorphisms in β-, β- and β-adrenergic receptors (β-ARs) have been associated with chronic non-communicable disorders, such as cardiovascular diseases, asthma, chronic obstructive pulmonary disease (COPD) and obesity, as well as β-agonists and antagonists response and toxicity. The purpose of this study was to determine the frequency distribution of genetic variants Ser49Gly and Arg389Gly, variants Gly16Arg and Gln27Glu, variant Trp64Arg in a Southeastern European Caucasian (SEC) population sample and to establish a comparison with existing data from other human populations. A sample of 431 men and 590 women volunteered to participate in this genotyping analysis after anonymization and de-identification. Read More

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November 2018

Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3.

Front Physiol 2018 28;9:1623. Epub 2018 Nov 28.

Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.

Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate (IS), which are currently considered as a non-classical CKD-specific risk factor for CVDs. The present study aimed to examine the effect of chronic exposure to IS on the hemostatic system and arterial thrombosis in a model without greater interferences from the uremic milieu consisting of additional uremic toxins. Read More

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November 2018

Blood Markers in Healthy-Aged Nonagenarians: A Combination of High Telomere Length and Low Amyloidβ Are Strongly Associated With Healthy Aging in the Oldest Old.

Front Aging Neurosci 2018 28;10:380. Epub 2018 Nov 28.

Department of Neurology, Donostia Universitary Hospital, San Sebastián, Spain.

Many factors may converge in healthy aging in the oldest old, but their association and predictive power on healthy or functionally impaired aging has yet to be demonstrated. By detecting healthy aging and in turn, poor aging, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell or PBMC telomere length, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously associated with poor aging or cognitive deterioration, and their combinations, in a cohort of "neurologically healthy" (both motor and cognitive) nonagenarians ( = 20) and functionally impaired, institutionalized nonagenarians ( = 38) recruited between 2014 and 2015. Read More

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November 2018

Health Dynamics in the Built Environment: An Urban Intensity Perspective - An Exploratory Study in Trinidad and Tobago.

Environ Health Insights 2018 29;12:1178630218811342. Epub 2018 Nov 29.

Centre for Environmental Studies and Applied Life Sciences, The University of Trinidad and Tobago, Arima, Trinidad and Tobago.

The built environment encompasses the physical components of the environment, inclusive of infrastructure, households, buildings, streets, and open spaces, within which individuals reside and carry out their daily activities. It affects both indirectly and directly on the outdoor and indoor physical environment as well as the socio-economic environment. The elements which comprise the built environment and those of the physical and socio-economic environments, which are affected by it, are recognised as key determinants of health. Read More

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November 2018

Macrogol (polyethylene glycol) 4000 without electrolytes in the symptomatic treatment of chronic constipation: a profile of its use.

Drugs Ther Perspect 2018 15;34(7):300-310. Epub 2018 Jun 15.

Springer, Private Bag 65901, Mairangi Bay 0754, Auckland, New Zealand.

Macrogol 4000, a biologically inert, non-absorbable osmotic laxative, is a highly effective and well-tolerated first-line option for the treatment of the symptoms of chronic idiopathic/functional constipation in children and adults. High-molecular-weight (HMW) macrogols ± electrolytes have generally similar efficacy profiles; however, the taste of macrogol 4000 is generally preferred over that of macrogol 3350 + electrolytes. Macrogol 4000 is more effective than lactulose in improving stool frequency and consistency, and is associated with less vomiting and flatulence. Read More

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Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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December 2018

Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors.

Neuropsychopharmacology 2018 Oct 11. Epub 2018 Oct 11.

Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.

Affective disorders arise from abnormal responses of the brain to prolonged exposure to challenging environmental stimuli. Recent work identified the orphan receptor GPR158 as a molecular link between chronic stress and depression. Here we reveal a non-canonical mechanism by which GPR158 exerts its effects on stress-induced depression by the complex formation with Regulator of G protein Signaling 7 (RGS7). Read More

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October 2018
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Normotensive non-dipping blood pressure profile does not predict the risk of chronic kidney disease progression.

Hypertens Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups. Read More

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December 2018

The neurobiological basis of narcolepsy.

Nat Rev Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery about 20 years ago that narcolepsy is caused by selective loss of the neurons producing orexins (also known as hypocretins) sparked great advances in the field. Here, we review the current understanding of how orexin neurons regulate sleep-wake behaviour and the consequences of the loss of orexin neurons. Read More

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December 2018

Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study.

Leukemia 2018 Dec 13. Epub 2018 Dec 13.

Department of Haematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Patients with chronic lymphocytic leukemia (CLL) have a high risk of bloodstream infections (BSI). BSI cause significant morbidity and mortality among CLL patients; approximately one-third of fatalities in CLL list infections as cause of death. All CLL patients in Denmark diagnosed between 2008 and 2016 were followed through registries for the event of a BSI. Read More

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December 2018

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells.

Cell Death Differ 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.

Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34 hematopoietic stem/progenitor cells (CD34/HSPCs) from healthy donors. Read More

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December 2018

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.

Nat Commun 2018 Dec 13;9(1):5293. Epub 2018 Dec 13.

Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More

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December 2018

Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa.

Transl Psychiatry 2018 Dec 13;8(1):277. Epub 2018 Dec 13.

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, 610041, Chengdu, China.

Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality. The underlying neurobiological mechanisms are not well understood, and high-resolution structural magnetic resonance brain imaging studies have given inconsistent results. Here we aimed to psychoradiologically define the most prominent and replicable abnormalities of gray matter volume (GMV) in AN patients, and to examine their relationship to demographics and clinical characteristics, by means of a new coordinate-based meta-analytic technique called seed-based d mapping (SDM). Read More

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December 2018
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Tissue engineering of human hair follicles using a biomimetic developmental approach.

Nat Commun 2018 Dec 13;9(1):5301. Epub 2018 Dec 13.

Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA.

Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs), into HSCs remains a major challenge. Here, we demonstrate a biomimetic approach for generation of human HFs within HSCs by recapitulating the physiological 3D organization of cells in the HF microenvironment using 3D-printed molds. Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF differentiation in HSCs. Read More

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December 2018
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Healthcare Resource Use, Cost, and Sick Leave Following Kidney Transplantation in Sweden: A Population-Based, 5-Year, Retrospective Study of Outcomes: COIN.

Ann Transplant 2018 Dec 14;23:852-866. Epub 2018 Dec 14.

Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden.

BACKGROUND Improved understanding of the impact of kidney transplantation on healthcare resource use/costs and loss of productivity could aid decision making about funding allocation and resources needed for the treatment of chronic kidney disease in stage 5. MATERIAL AND METHODS This was a retrospective study utilizing data from Swedish national health registers of patients undergoing kidney transplantation. Primary outcomes were renal disease-related healthcare resource utilization and costs during the 5 years after transplantation. Read More

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December 2018
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