8,608 results match your criteria Chronic Fatigue Syndrome


Does Motor Cortex Engagement During Movement Preparation Differentially Inhibit Nociceptive Processing in Patients with Chronic Whiplash Associated Disorders, Chronic Fatigue Syndrome and Healthy Controls? An Experimental Study.

J Clin Med 2020 May 18;9(5). Epub 2020 May 18.

Pain in Motion International Research Group, www.paininmotion.be, Brussels, Belgium.

Background: Patients with chronic fatigue syndrome (CFS) and chronic whiplash associated disorders (cWAD) present a reduced ability to activate central descending nociceptive inhibition after exercise, compared to measurements before exercise. It was hypothesised that a dysfunctional motor-induced inhibition of nociception partly explains this dysfunctional exercise-induced hypoalgesia. This study investigates if engagement of the motor system during movement preparation inhibits nociception-evoked brain responses in these patients as compared to healthy controls (HC). Read More

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http://dx.doi.org/10.3390/jcm9051520DOI Listing

Rigosertib in combination with azacitidine in patients with myelodysplastic syndromes or acute myeloid leukemia: Results of a phase 1 study.

Leuk Res 2020 May 12;94:106369. Epub 2020 May 12.

Tisch Cancer Institute, Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, United States.

Phase 1 results from a Phase 1/2 study comprise 18 patients with myelodysplastic syndromes (MDS; n = 9), acute myeloid leukemia (AML; n = 8), and chronic myelomonocytic leukemia (CMML; n = 1) who were either hypomethylating agent naïve (n = 10) or relapsed/refractory following prior hypomethylating agent therapy (n = 8) (NCT01926587). Patients received oral rigosertib, an inhibitor of Ras-effector pathways, in 3 successive cohorts (140 mg twice daily, 280 mg twice daily, or 840 mg/day [560 mg morning/280 mg evening]) for 3 weeks of a 4-week cycle. Patients received parenteral azacitidine (75 mg/m/day × 7 days) during the second week; the cycle repeated every 4 weeks. Read More

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http://dx.doi.org/10.1016/j.leukres.2020.106369DOI Listing

Sleep problems in adolescents with CFS: A case-control study nested within a prospective clinical cohort.

Clin Child Psychol Psychiatry 2020 May 22:1359104520918364. Epub 2020 May 22.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

Sleep problems have a negative impact on a range of outcomes and are very common in adolescents with chronic fatigue syndrome (CFS). We aimed to (a) establish whether adolescents with CFS have more self-reported sleep problems than illness controls as well as healthy controls, (b) investigate changes in sleep problems and (c) explore the extent to which sleep problems at baseline predict fatigue and functioning at follow-up in adolescents with CFS. The Insomnia Scale was completed by 121 adolescents with CFS, 78 healthy adolescents and 27 adolescents with asthma. Read More

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http://dx.doi.org/10.1177/1359104520918364DOI Listing

Patients' experiences and effects of non-pharmacological treatment for myalgic encephalomyelitis/chronic fatigue syndrome - a scoping mixed methods review.

Int J Qual Stud Health Well-being 2020 Dec;15(1):1764830

Faculty of Health Studies, VID Specialized University , Oslo, Norway.

Purpose: The EU COST Action 15111 collaboration on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) aims to assess current research and identify knowledge gaps in Europe. Presently, our purpose is to map the effects of non-pharmacological therapies (NPTs) for ME/CFS, and what patients find important in the treatment process.

Methods: A scoping mixed methods literature review of European studies identified 16 papers fulfiling our inclusion criteria. Read More

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http://dx.doi.org/10.1080/17482631.2020.1764830DOI Listing
December 2020

The feasibility and acceptability of an early intervention in primary care to prevent chronic fatigue syndrome (CFS) in adults: randomised controlled trial.

Pilot Feasibility Stud 2020 12;6:65. Epub 2020 May 12.

2Bristol Medical School, University of Bristol, Bristol, BS8 1NU UK.

Background: Chronic fatigue syndrome (CFS, also known as myalgic encephalomyelitis (ME)) is defined as fatigue that is disabling, is accompanied by additional symptoms and persists for ≥ 4 months. Treatment of CFS/ME aims to help patients manage their symptoms and make lifestyle adjustments. We do not know whether intervening early in primary care (< 4 months after onset of fatigue) can prevent the development of CFS/ME. Read More

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http://dx.doi.org/10.1186/s40814-020-00595-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216523PMC

Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study.

Front Med (Lausanne) 2020 29;7:162. Epub 2020 Apr 29.

Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with high symptom burden, of unknown etiology, with no established treatment. We observed patients with long-standing ME/CFS who got cancer, and who reported improvement of ME/CFS symptoms after chemotherapy including cyclophosphamide, forming the basis for this prospective trial. This open-label phase II trial included 40 patients with ME/CFS diagnosed by Canadian criteria. Read More

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http://dx.doi.org/10.3389/fmed.2020.00162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201056PMC

Fallout from the Covid-19 pandemic - should we prepare for a tsunami of post viral depression?

Ir J Psychol Med 2020 May 15:1-10. Epub 2020 May 15.

Senior Registrar, Department of Psychiatry, University Hospital Limerick.

The current Covid-19 pandemic is not just a medical and social tragedy, but within the threat of the outbreak looms the potential for a significant and persistent negative mental health impact, based on previous experience with other pandemics such as SARS in 2003 and the earlier H1N1 outbreak of 1918. This piece will highlight the links between depression and viral illnesses and explore important overlaps with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, potentially implicating inflammatory mechanisms in those exposed to a range of viral agents. While containment of psychological distress currently focuses on social anxiety and quarantine measures, a second wave of psychological morbidity due to viral illness may be imminent. Read More

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http://dx.doi.org/10.1017/ipm.2020.40DOI Listing

A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID).

J Transl Med 2020 May 13;18(1):198. Epub 2020 May 13.

National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia.

Background: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) is a complex illness that has an unknown aetiology. It has been proposed that metabolomics may contribute to the illness pathogenesis of CFS/ME/SEID. In metabolomics, the systematic identification of measurable changes in small molecule metabolite products have been identified in cases of both monogenic and heterogenic diseases. Read More

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http://dx.doi.org/10.1186/s12967-020-02356-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222338PMC

A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning.

BMC Gastroenterol 2020 May 11;20(1):144. Epub 2020 May 11.

Division of Developmental and Behavioral Sciences, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Background: Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relationships between nausea and mucosal inflammation as defined by antral and duodenal eosinophil and mast cell densities. A secondary aim was to assess relationships between nausea and other gastrointestinal symptoms, non-gastrointestinal somatic symptoms, and psychological dysfunction. Read More

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http://dx.doi.org/10.1186/s12876-020-01291-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216423PMC

The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.

Nutrients 2020 May 5;12(5). Epub 2020 May 5.

Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria.

: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. : The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and severity of symptoms associated with iron deficiency before and after (intravenous or oral) iron supplementation in iron deficient blood donors.

Methods/design: Prospective, randomized, controlled, single-centre trial. Read More

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http://dx.doi.org/10.3390/nu12051313DOI Listing

The Effects of Adalimumab in Behçet Disease Patients on Clinical Manifestations and on Pro-Inflammatory Cytokines Milieu: Long-Term Follow-Up.

Isr Med Assoc J 2020 May;22(5):289-293

Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Behçet's disease is a multi-systemic chronic relapsing inflammatory disease, classified among the vasculitides. The heterogeneity of clinical manifestations challenges the disease management.

Objectives: To assess efficacy and safety of adalimumab in patients with active persistent Behçet's arthritis who did not respond to disease-modifying anti-rheumatic drugs and to assess the impact of treatment on the cytokine milieu. Read More

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Neurasthenia: tracing the journey of a protean malady.

Int Rev Psychiatry 2020 May 7:1-9. Epub 2020 May 7.

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neuresthenia has had its popularity waxing and waning over the years. This review article traces the path and trajectory of the concept of this disorder, how it changed and varied over time, to the current times, when it has been almost forgotten and the concept is heading towards oblivion. Although its place in the diagnostic systems is currently in question, neurasthenia is still part of professional conversations and practice. Read More

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http://dx.doi.org/10.1080/09540261.2020.1758638DOI Listing

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Ocul Surf 2020 May 3. Epub 2020 May 3.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.04.005DOI Listing

Epidemiological analysis of the early 38 fatalities in Hubei, China, of the coronavirus disease 2019.

J Glob Health 2020 Jun;10(1):011004

School of Nursing, China Medical University, Shenyang, Liaoning, China.

Background: Since the emergence of coronavirus disease 2019 (COVID-19) in Hubei province of China by the end of 2019, it has burned its way across the globe, resulting in a still fast-growing death toll that far exceeded those from severe acute respiratory syndrome (SARS) in less than two months. As there is a paucity of evidence on which population is more likely to progress into severe conditions among cases, we looked into the first cluster of death cases, aiming to add to current evidence and reduce panic among the population.

Methods: We prospectively collected the demographic and clinical data of the first 38 fatalities whose information was made public by the Health Commission of Hubei province and the official Weibo account of China Central Television news center, starting from 9 January through 24 January 2020. Read More

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http://dx.doi.org/10.7189/jogh-10-011004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183246PMC

Auricular acupuncture for insomnia of chronic fatigue syndrome: a case report.

Acupunct Med 2020 May 5:964528420920279. Epub 2020 May 5.

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

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http://dx.doi.org/10.1177/0964528420920279DOI Listing
May 2020
1.676 Impact Factor

Mal de débarquement syndrome – “sickness of disembarkment”

Orv Hetil 2020 05 1;161(20):846-851. Epub 2020 May 1.

Bajcsy-Zsilinszky Kórház, Budapest.

Mal de débarquement syndrome is an uncommon vestibular disorder characterized by a constant sensation of swaying or motion after one disembarks from a vehicle such as a ship or plane, however, spontaneous onset also appears. These symptoms temporarily subside when the patient is subjected again to passive motion like driving a car. Chronic fatigue, anxiety, and depression are frequently associated with primary symptoms. Read More

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http://dx.doi.org/10.1556/650.2020.31729DOI Listing

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

QJM 2020 May 3. Epub 2020 May 3.

School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.

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http://dx.doi.org/10.1093/qjmed/hcaa090DOI Listing

Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.

Neurosci Res 2020 Apr 30. Epub 2020 Apr 30.

Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. Electronic address:

Chronic fatigue syndrome (CFS) is characterized by long-lasting fatigue, and a range of symptoms, and is involved in homeostasis disruption. CFS patients frequently complain of low grade fever or chill even under normal body temperature indicating that thermosensory or thermoregulatory functions might be disturbed in CFS. However, little is known about the detailed mechanisms. Read More

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http://dx.doi.org/10.1016/j.neures.2020.04.005DOI Listing
April 2020
1.937 Impact Factor

A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques.

PLoS One 2020 30;15(4):e0232475. Epub 2020 Apr 30.

National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.

Background: Myalgic encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a multi-system illness characterised by a diverse range of debilitating symptoms including autonomic and cognitive dysfunction. The pathomechanism remains elusive, however, neurological and cognitive aberrations are consistently described. This systematic review is the first to collect and appraise the literature related to the structural and functional neurological changes in ME/CFS patients as measured by neuroimaging techniques and to investigate how these changes may influence onset, symptom presentation and severity of the illness. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232475PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192498PMC

Chronic Pain Syndromes and Their Laryngeal Manifestations.

JAMA Otolaryngol Head Neck Surg 2020 Apr 30. Epub 2020 Apr 30.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.

Importance: Fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), and chronic fatigue syndrome (CFS) are traditionally considered as distinct entities grouped under chronic pain syndrome (CPS) of an unknown origin. However, these 3 disorders may exist on a spectrum with a shared pathophysiology.

Objective: To investigate whether the clinical presentation of FMS, IBS, and CFS is similar in a population presenting with voice and laryngeal disorders. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.0530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193518PMC

Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study.

BMC Infect Dis 2020 Apr 29;20(1):311. Epub 2020 Apr 29.

Department of Hematology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60, Jingzhong Road, Jingzhou Central Hospital, Jingzhou, 434020, Hubei Province, China.

Background: Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described.

Methods: We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. Read More

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http://dx.doi.org/10.1186/s12879-020-05010-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188494PMC

Cognitive-behavioural therapy combined with music therapy for chronic fatigue following Epstein-Barr virus infection in adolescents: a feasibility study.

BMJ Paediatr Open 2020 9;4(1):e000620. Epub 2020 Apr 9.

Pediatrics, Akershus University Hospital, Lørenskog, Norway.

​background: Cognitive-behavioural therapy (CBT) is effective in chronic fatigue syndrome. However, CBT has not been investigated in postinfectious chronic fatigue (CF), nor is it known whether addition of therapeutic elements from other disciplines might be feasible. We studied the feasibility of a combined CBT and music therapy intervention for CF following Epstein-Barr virus (EBV) infection in adolescents. Read More

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http://dx.doi.org/10.1136/bmjpo-2019-000620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173952PMC

Disseminated histoplasmosis in primary Sjögren syndrome: A case report.

World J Clin Cases 2020 Apr;8(7):1319-1325

Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Sjögren syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphic fungus . In patients with primary SS (PSS), disseminated histoplasmosis (DH) is extremely rare. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i7.1319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176620PMC

The importance of contextual aspects in the care for patients with functional somatic symptoms.

Med Hypotheses 2020 Apr 11;142:109731. Epub 2020 Apr 11.

University of Groningen & University Medical Center Groningen, Interdisciplinary Center for Psychopathology of Emotion Regulation (ICPE), PO Box 30.001 (CC72), 9700 RB Groningen, the Netherlands.

Functional somatic symptoms refer to physical symptoms that cannot be (bio) medically explained. The pattern or clustering of such symptoms may lead to functional syndromes like chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, among many others. Since the underlying pathophysiology remains unknown, several explanatory models have been proposed, nearly all including social and psychological parameters. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109731DOI Listing

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset.

Front Immunol 2020 9;11:578. Epub 2020 Apr 9.

Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität (FU) Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany.

Single nucleotide polymorphisms (SNP) in various genes have been described to be associated with susceptibility to autoimmune disease. In this study, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients and controls were genotyped for five immune gene SNPs in tyrosine phosphatase non-receptor type 22 (, rs2476601), cytotoxic T-lymphocyte-associated protein 4 (, rs3087243), tumor necrosis factor (, rs1800629 and rs1799724), and interferon regulatory factor 5 (, rs3807306), which are among the most important risk variants for autoimmune diseases. Analysis of 305 ME/CFS patients and 201 healthy controls showed significant associations of the rs2476601 and rs3087243 autoimmunity-risk alleles with ME/CFS. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161310PMC

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Immunohorizons 2020 Apr 23;4(4):201-215. Epub 2020 Apr 23.

Lehrstuhl für Mikrobiologie, Julius-Maximilians Universität Würzburg, 97074 Würzburg, Germany;

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disorder with many possible triggers. Human herpesvirus (HHV)-6 and HHV-7 are two infectious triggers for which evidence has been growing. To understand possible causative role of HHV-6 in ME/CFS, metabolic and antiviral phenotypes of U2-OS cells were studied with and without chromosomally integrated HHV-6 and with or without virus reactivation using the histone deacetylase inhibitor trichostatin-A. Read More

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http://dx.doi.org/10.4049/immunohorizons.2000006DOI Listing

A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes.

BMC Psychiatry 2020 Apr 22;20(1):182. Epub 2020 Apr 22.

University of Technology Sydney, Faculty of Health, IMPACCT -Improving Palliative, Aged and Chronic Care through Clinical Research and Translation, Sydney, NSW, Australia.

Background: Delirium is a serious and distressing neurocognitive disorder of physiological aetiology that is common in advanced cancer. Understanding of delirium pathophysiology is largely hypothetical, with some evidence for involvement of inflammatory systems, neurotransmitter alterations and glucose metabolism. To date, there has been limited empirical consideration of the distinction between delirium pathophysiology and that of the underlying disease, for example, cancer where these mechanisms are also common in advanced cancer syndromes such as pain and fatigue. Read More

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http://dx.doi.org/10.1186/s12888-020-02584-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178636PMC

A man in his nineties with fever and dry cough.

Tidsskr Nor Laegeforen 2020 04 20;140(6). Epub 2020 Mar 20.

Background: COVID-19 can cause a fatal outcome in elderly patients, as this case report illustrates.

Case Presentation: An active male in his nineties with a high level of function, despite several severe chronic diseases, was admitted to Oslo University Hospital after two days of fatigue, fever, dyspnoea and dry cough. He scored qSOFA 1 of 3 points due to high respiratory rate, and SIRS 2 of 4 points due to high respiratory rate and fever of 39. Read More

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http://dx.doi.org/10.4045/tidsskr.20.0218DOI Listing

Pediatric-Onset Postural Orthostatic Tachycardia Syndrome in a Single Tertiary Care Center.

J Child Neurol 2020 Apr 21:883073820916260. Epub 2020 Apr 21.

Center for Pediatric Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Aim: We characterize the pediatric postural orthostatic tachycardia syndrome (POTS) population seen at a single tertiary care referral center.

Method: Retrospective chart review of all pediatric POTS patients seen in our center between 2015 and 2017. Pediatric POTS was defined as chronic, at least 3 months, symptoms of orthostatic intolerance associated with excessive orthostatic tachycardia as determined by tilt table testing with orthostatic heart rate increment of ≥40 bpm within 5 minutes of head-up tilt or absolute orthostatic heart rate ≥130 bpm for patients 13 years old and younger and ≥120 bpm for those 14 years and older. Read More

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http://dx.doi.org/10.1177/0883073820916260DOI Listing

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome.

J Transl Med 2020 Apr 19;18(1):173. Epub 2020 Apr 19.

Department of Internal Medicine, European Hospital, Marseille, France.

Background: In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles.

Methods: Seventy-two patients were examined at rest, during an incremental cycling exercise and during a 10-min post-exercise recovery period. Read More

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http://dx.doi.org/10.1186/s12967-020-02341-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168976PMC

Fatigue Symptoms during the First Year after ARDS.

Chest 2020 Apr 15. Epub 2020 Apr 15.

Division of Pulmonary & Critical Care Medicine, Department of Physical & Rehabilitative Medicine, Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine Baltimore, MD, USA.

Background: Fatigue is commonly reported by acute respiratory distress syndrome (ARDS) survivors, but empirical data are scarce.

Research Question: We evaluated fatigue prevalence and associated variables in a prospective study of ARDS survivors.

Study Design And Methods: This analysis is part of the ARDSNet Long-term Outcomes Study (ALTOS), conducted at 38 U. Read More

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http://dx.doi.org/10.1016/j.chest.2020.03.059DOI Listing

Chronic fatigue syndrome: help young people regain their lives.

Authors:

Arch Dis Child 2020 May;105(5):451

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http://dx.doi.org/10.1136/archdischild-2020-319237DOI Listing

Diagnosis and treatment of primary biliary cholangitis.

United European Gastroenterol J 2020 Apr 16:2050640620919585. Epub 2020 Apr 16.

I Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Primary biliary cholangitis is a cholestatic, chronic autoimmune liver disease with a wide individual variation in disease progression. The diagnosis is predominantly based on chronic elevation of alkaline phosphatase and the presence of anti-mitochondrial antibodies or other specific antinuclear antibodies (i.e. Read More

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http://dx.doi.org/10.1177/2050640620919585DOI Listing

Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies.

Front Med (Lausanne) 2020 31;7:108. Epub 2020 Mar 31.

Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Metabolic profiling studies have recently indicated dysfunctional mitochondria in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This includes an impaired function of pyruvate dehydrogenase complex (PDC), possibly driven by serum factor(s), which leads to inadequate adenosine triphosphate generation and excessive lactate accumulation. A reminiscent energy blockade is likely to occur in primary biliary cholangitis (PBC), caused by anti-PDC autoantibodies, as recently proposed. Read More

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http://dx.doi.org/10.3389/fmed.2020.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136523PMC

Correlates of 1-Year Change in Quality of Life in Patients with Urologic Chronic Pelvic Pain Syndrome: Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.

J Urol 2020 Apr 14:101097JU0000000000001080. Epub 2020 Apr 14.

Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: To evaluate and identify baseline factors associated with change in health-related quality of life (HRQOL) among patients with interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: A total of 191 men and 233 women with IC/BPS or CP/CPPS (collectively referred to as urologic chronic pelvic pain syndrome, or UCPPS) were followed for 12 months with bimonthly completion of the Short Form 12 (SF-12) to assess general mental and physical HRQOL, and with biweekly assessment of condition-specific HRQOL using the Genitourinary Pain Index. A functional clustering algorithm was used to classify participants as improved, stable, or worsened for each HRQOL measure. Read More

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http://dx.doi.org/10.1097/JU.0000000000001080DOI Listing

Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS.

J Cell Mol Med 2020 May 14;24(10):5865-5877. Epub 2020 Apr 14.

Institute for Neuro Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. Read More

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http://dx.doi.org/10.1111/jcmm.15260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214164PMC

Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls: A Case-Control Study.

Pain Med 2020 Apr 14. Epub 2020 Apr 14.

Pain in Motion International Research Group, Vrije Universiteit Brussel, Brussels, Belgium.

Objective: Laser-evoked potentials (LEPs) are among the reliable neurophysiological tools to investigate patients with neuropathic pain, as they can provide an objective account of the functional status of thermo-nociceptive pathways. The goal of this study was to explore the functioning of the nociceptive afferent pathways by examining LEPs in patients with chronic whiplash-associated disorders (cWAD), patients with chronic fatigue syndrome (CFS), and healthy controls (HCs).

Design: Case-control study. Read More

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http://dx.doi.org/10.1093/pm/pnaa068DOI Listing

[Covid-19 in patients on dialysis: infection prevention and control strategies].

G Ital Nefrol 2020 Apr 9;37(2). Epub 2020 Apr 9.

Board Member of European Specialist Nurses Organization (ESNO), Brussels, Belgio.

Covid-19 is a disease caused by a new coronavirus presenting a variability of flu-like symptoms including fever, cough, myalgia and fatigue; in severe cases, patients develop pneumonia, acute respiratory distress syndrome, sepsis and septic shock, that can result in their death. This infection, which was declared a global epidemic by the World Health Organization, is particularly dangerous for dialysis patients, as they are frail and more vulnerable to infections due to the overlap of multiple pathologies. In patients with full-blown symptoms, there is a renal impairment of various degrees in 100% of the subjects observed. Read More

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Acupuncture for Chronic Fatigue Syndrome: An Overview of Systematic Reviews.

Chin J Integr Med 2020 Apr 1. Epub 2020 Apr 1.

School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Objective: To evaluate the quality of the existing studies and summarize evidence of important outcomes of meta-analyses/systematic reviews (MAs/SRs) of CFS.

Methods: Potentially eligible studies were searched in the following electronic databases from inception to 1 September, 2019: Chinese Biomedical Literature Database (CBM), China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), WanFang Database (WF), Web of Science, Embase, PubMed and Cochrane Library. Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence. Read More

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http://dx.doi.org/10.1007/s11655-020-3195-3DOI Listing

The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function.

PLoS One 2020 10;15(4):e0231136. Epub 2020 Apr 10.

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Myalgic encephalomyelitis/ Chronic fatigue syndrome (ME/CFS) has been associated with abnormalities in mitochondrial function. In this study we have analysed previous bioenergetics data in peripheral blood mononuclear cells (PBMCs) using new techniques in order to further elucidate differences between ME/CFS and healthy control cohorts. We stratified our ME/CFS cohort into two individual cohorts representing moderately and severely affected patients in order to determine if disease severity is associated with bioenergetic function in PBMCs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147788PMC

Emotional Awareness Correlated With Number of Awakenings From Polysomnography in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-A Pilot Study.

Front Psychiatry 2020 26;11:222. Epub 2020 Mar 26.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Introduction: Unrefreshing sleep is one of the diagnostic criteria in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which could be explained by sleep disorders, for example obstructive sleep apnea, reported in our previous study with polysomnography. Our previous findings also indicate difficulties in emotional regulation when measuring alexithymia by TAS-20 (Toronto Alexithymia Scale) and level of emotional awareness by LEAS (Level of Emotional Awareness Scale) in ME/CFS patients. However, the reasons for this are unknown. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113367PMC

The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE).

Healthcare (Basel) 2020 Apr 7;8(2). Epub 2020 Apr 7.

Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.

We have developed a Europe-wide approach to investigating the economic impact of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), facilitating acquisition of information on the economic burden of ME/CFS, and international comparisons of economic costs between countries. The economic burden of ME/CFS in Europe appears large, with productivity losses most significant, giving scope for substantial savings through effective prevention and treatment. However, economic studies of ME/CFS, including cost-of-illness analyses and economic evaluations of interventions, are problematic due to different, arbitrary case definitions, and unwillingness of doctors to diagnose it. Read More

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http://dx.doi.org/10.3390/healthcare8020088DOI Listing

[The network investigation on knowledge, attitude and practice about COVID-19 of the residents in Anhui Province].

Zhonghua Yu Fang Yi Xue Za Zhi 2020 Apr;54(4):367-373

School of Public health, Wannan Medical College/Institute of Chronic Disease Control and Prevention, Wannan Medical College, Wuhu 241002, China.

To analyze the current situation of the knowledge, attitudes and practice about COVID-19 of the residents in Anhui Province. Anonymous network sampling survey was carried out with an electronic questionnaire that designed by the questionnaire star, and a total of 4 016 subjects from Anhui province were investigated. The content of the survey includes that the basic information of subjects,the residents' knowledge, attitudes and practice about COVID-19, as well as their satisfaction with the prevention and control measures adopted by the government and health authorities and the suggestions on future prevention. Read More

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http://dx.doi.org/10.3760/cma.j.cn112150-20200205-00069DOI Listing

[Headache in puerperium].

Ned Tijdschr Geneeskd 2020 Mar 5;164. Epub 2020 Mar 5.

Haaglanden Medisch Centrum, Den Haag. Afd. Radiologie.

Background: Sheehan's syndrome is a rare complication of excessive postpartum hemorrhage with impaired function of the pituitary gland (hypopituitarism). Clinical presentation includes headache, fatigue, nausea, symptoms due to electrolyte imbalance and pituitary hormone insufficiency. Cranial imaging can support the diagnosis if pituitary gland ischemia or empty sella sign is detected. Read More

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Low-risk myelodysplastic syndrome managed with an erythroid-stimulating agent for 10 years.

BMJ Case Rep 2020 Apr 6;13(4). Epub 2020 Apr 6.

Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

A 57-year-old man with a history of diabetes and coronary artery disease was referred to haematology for the evaluation of anaemia in the setting of non-cardiac chest pain, fatigue, dyspnoea and dizziness. Previous investigations into these recurrent symptoms focused on a re-evaluation of his known ischaemic heart disease, which required multiple percutaneous interventions with stenting several years ago. In the year leading up to his referral, the patient required two transfusions during separate hospitalisations. Read More

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http://dx.doi.org/10.1136/bcr-2019-232285DOI Listing

HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome.

Auto Immun Highlights 2019 Dec 15;10(1):12. Epub 2019 Nov 15.

1Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, SP 05403-000 Brazil.

Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Read More

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http://dx.doi.org/10.1186/s13317-019-0122-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065355PMC
December 2019

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies.

World Allergy Organ J 2020 Mar 3;13(3):100106. Epub 2020 Apr 3.

Department of Otolaryngology- Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.

Allergic rhinitis affects the quality of life of millions of people worldwide. Air pollution not only causes morbidity, but nearly 3 million people per year die from unhealthy indoor air exposure. Furthermore, allergic rhinitis and air pollution interact. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132263PMC

The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS).

Allergy Asthma Clin Immunol 2020 30;16:21. Epub 2020 Mar 30.

3St Anthony's Hospital, 801 London Road, Cheam, SM3 9DW UK.

Background: Fatigue, sleep disturbance and altered mood are frequently reported in patients with primary antibody deficiency syndrome (PADS) on adequate immunoglobulin replacement therapy. This study aimed to determine the frequency of symptoms compatible with chronic fatigue syndrome (CFS) in patients with PADS.

Methods: The study involved the distribution of 682 self-completed postal questionnaires to ascertain the presence and frequency of symptoms compatible with CFS in patients with PADS. Read More

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http://dx.doi.org/10.1186/s13223-020-0417-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106611PMC

Neuroimaging Findings in Chronic Hepatitis C Virus Infection: Correlation with Neurocognitive and Neuropsychiatric Manifestations.

Int J Mol Sci 2020 Apr 2;21(7). Epub 2020 Apr 2.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.

Chronic hepatitis C virus (HCV) infection is commonly associated with neurocognitive dysfunction, altered neuropsychological performance and neuropsychiatric symptoms. Quantifiable neuropsychological changes in sustained attention, working memory, executive function, verbal learning and recall are the hallmark of HCV-associated neurocognitive disorder (HCV-AND). This constellation is at variance with the neuropsychological complex that is seen in minimal hepatic encephalopathy, which is typified by an array of alterations in psychomotor speed, selective attention and visuo-constructive function. Read More

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http://dx.doi.org/10.3390/ijms21072478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177498PMC

A Clinical Review of Primary Biliary Cholangitis.

Authors:
Richard Pullen

Gastroenterol Nurs 2020 Mar/Apr;43(2):E48-E55

Richard Pullen, EdD, MSN, RN, CMSRN, CNE-cl, is Full Professor, Texas Tech University Health Sciences Center School of Nursing, Lubbock, Texas.

Primary biliary cholangitis is a slowly progressive immune-mediated cholestatic disease that causes a destruction of the intrahepatic bile ducts and may lead to cirrhosis of the liver, end-stage liver disease, and the need for liver transplantation. The disease is among the most common reasons why adults require liver transplantation. The primary signs of the disease include the presence of antimitochondrial and antinuclear antibodies, elevated alkaline phosphatase, hyperbilirubinemia, hypercholesterolemia, and histologic features, such as intense inflammation with a florid duct lesion and hepatic fibrosis. Read More

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http://dx.doi.org/10.1097/SGA.0000000000000480DOI Listing