7,943 results match your criteria Chronic Fatigue Syndrome


A Survey on Human T-cell Lymphotropic Virus Type 1 (HTLV-1) and Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Coinfection in Tehran, Iran.

J Pharm Bioallied Sci 2018 Jul-Sep;10(3):166-171

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus, which has been detected in patients with prostate cancer, chronic fatigue syndrome, and general population with a number of acquired infections such as infection with human T-cell lymphotropic virus (HTLV) and human immunodeficiency virus (HIV). The aim of this study was to determine the HTLV-1 and XMRV coinfection for the first time in Iranian patients who were admitted to the Tehran hospitals.

Materials And Methods: Two hundred and ninety one patients suspected with HTLV-1 were referred to the hospitals affiliated to the Iran University of Medical Sciences, Tehran, Iran from April 2012 to October 2016. Read More

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September 2018

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Front Pediatr 2018 4;6:242. Epub 2018 Sep 4.

Workwell Foundation, Ripon, CA, United States.

Concise methodological directions for administration of serial cardiopulmonary exercise testing (CPET) are needed for testing of patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Maximal CPET is used to evaluate the coordinated metabolic, muscular, respiratory and cardiac contributions to energy production in patients with ME/CFS. In this patient population, CPET also elicits a robust post-exertional symptom flare (termed, post-exertional malaise); a cardinal symptom of the disease. Read More

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September 2018

Defining the prevalence and symptom burden of those with self-reported severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a two-phase community pilot study in the North East of England.

BMJ Open 2018 Sep 19;8(9):e020775. Epub 2018 Sep 19.

Institute of Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

Objectives: To define the prevalence of severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and its clinical characteristics in a geographically defined area of Northern England. To understand the feasibility of a community-based research study in the severely affected CFS/ME group.

Design: A two-phase clinical cohort study to pilot a series of investigations in participants own homes. Read More

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September 2018
2 Reads

School Nurses Can Improve the Lives of Students With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

NASN Sch Nurse 2018 Sep 15:1942602X18795299. Epub 2018 Sep 15.

Professor of Education and Coordinator of Middle-Level Education, Delaware State University, Dover, DE.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic illness that is defined and diagnosed by its symptoms: extreme fatigue made worse by physical and mental activity, pain and decreased mental stamina, among others. A long-held, erroneous belief that ME/CFS is not a physiological illness has persisted among some clinicians, leading to the denial of a patient's physical illness and attributing the symptoms to other causes. The debilitating effects of ME/CFS in the pediatric population can affect all aspects of academic, social, emotional, and physical development. Read More

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September 2018

Pitfalls in cytokine measurements - Plasma TGF-β1 in chronic fatigue syndrome.

Neth J Med 2018 Sep;76(7):310-313

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Serum TGF-β1 concentrations are reported to be elevated in chronic fatigue syndrome (CFS). However, measurement of circulating cytokines is a complex procedure and control of pre-analytical procedures is essential. The objective of the current study was to measure circulating TGF-β1 concentrations in CFS patients compared to healthy controls, taking into account differences in pre-analytical procedures. Read More

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September 2018
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Why do some ME/CFS patients benefit from treatment with sodium dichloroacetate, but others do not?

Authors:
Frank Comhaire

Med Hypotheses 2018 Nov 25;120:65-67. Epub 2018 Aug 25.

Gent University, Belgium. Electronic address:

Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably to treatment with sodium dichloroacetate (DCA), which enhances the activity of the mitochondrial enzyme pyruvate dehydrogenase, but other patients experience no benefit from this substance. In a prospective trial including 35 ME/CFS patients, logistic regression analysis with stepwise elimination has identified 6 pre-treatment characteristics allowing for the differentiation between responders (n = 13) and non-reponders (n = 22) with high accuracy (P < 0. Read More

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November 2018
1 Read

Unusual presentation of pancreatitis with extrapancreatic manifestations.

BMJ Case Rep 2018 Sep 15;2018. Epub 2018 Sep 15.

Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.

Pancreatitis, panniculitis and polyarthritis syndrome (PPP syndrome) is a rare and complex manifestation of pancreatitis that is currently reported in few cases. We present this case regarding a 77-year-old man who presented unusually with a 6-week history of bilateral lesions on his lower limbs. During this time, he experienced increasing fatigue, joint pain, and reported fevers and significant weight loss. Read More

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September 2018
2 Reads

The effects of warm water immersion on blood pressure, heart rate and heart rate variability in people with chronic fatigue syndrome.

S Afr J Physiother 2018 28;74(1):442. Epub 2018 Aug 28.

Department of Health and Rehabilitation Sciences, University of Cape Town, South Africa.

Background: Chronic fatigue syndrome (CFS) is a central sensitisation syndrome with abnormalities in autonomic regulation of blood pressure (BP), heart rate (HR) and heart rate variability (HRV). Prior to exploring the effects of hydrotherapy as a treatment for this population, changes in BP, HR and HRV during warm water immersion need to be established.

Objectives: The study aimed to determine the effects of warm water immersion on BP, HR and HRV in adults with CFS compared to matched-pair healthy adults. Read More

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August 2018
2 Reads

Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study.

Ann Behav Med 2018 Sep;52(10):865-877

Department of Psychological and Brain Sciences and Urology, University of Iowa, Iowa City, IA, USA.

Background: Adverse Childhood Experiences (ACEs) such as sexual and physical violence, serious illness, and bereavement have been linked to number of chronic pain conditions in adulthood, and specifically to urologic chronic pelvic pain syndrome (UCPPS).

Purpose: We sought to characterize the prevalence of ACEs in UCPPS using a large well-characterized cohort in comparison with a group of healthy controls. We also sought to determine the association of ACE severity with psychological factors known to impact pain and to determine whether ACEs are associated with patterns of improvement or worsening of symptom over a year of naturalistic observation. Read More

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September 2018
2 Reads

A Brief Questionnaire to Assess Post-Exertional Malaise.

Diagnostics (Basel) 2018 Sep 11;8(3). Epub 2018 Sep 11.

Center for Community Research, Department of Psychology, DePaul University, Chicago, IL 60604, USA.

Post-exertional malaise (PEM) is a key symptom of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS). Currently, five PEM-items from the DePaul Symptom Questionnaire (DSQ) were recommended as a first step in measuring this symptom for patients with ME and CFS by the National Institutes of Health/Centers for Disease Control and Prevention (NIH/CDC) Common Data Elements' (CDE) working group. The second step in this process, as recommended by the NIH/CDC CDE working group, involves assembling information from various sources to confirm the presence of PEM. Read More

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September 2018
2 Reads

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Analyst 2018 Sep 12. Epub 2018 Sep 12.

Department of Engineering Science, University of Oxford, Begbroke Science Park, Woodstock Road, Oxford, OX5 1PF, UK.

Chronic fatigue syndrome (CFS), also called myalgic encephalomyelitis (ME), is a debilitating disorder characterized by physical and mental exhaustion. Mitochondrial and energetic dysfunction has been investigated in CFS patients due to a hallmark relationship with fatigue; however, no consistent conclusion has yet been achieved. Single-cell Raman spectra (SCRS) are label-free biochemical profiles, indicating phenotypic fingerprints of single cells. Read More

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September 2018

Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Int J Mol Sci 2018 Sep 9;19(9). Epub 2018 Sep 9.

School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.

Application of protocols without parameter standardization and appropriate controls has led manual therapy (MT) and other physiotherapy-based approaches to controversial outcomes. Thus, there is an urgency to carefully define standard protocols that elevate physiotherapy treatments to rigorous scientific demands. One way in which this can be achieved is by studying gene expression and physiological changes that associate to particular, parameter-controlled, treatments in animal models, and translating this knowledge to properly designed, objective, quantitatively-monitored clinical trials (CTs). Read More

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September 2018
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Myalgic Encephalomyelitis (ME) or What? An Operational Definition.

Authors:
Frank Twisk

Diagnostics (Basel) 2018 Sep 8;8(3). Epub 2018 Sep 8.

ME-de-Patiënten Foundation, Zonnedauw 15, 1906 HB Limmen, The Netherlands.

Myalgic encephalomyelitis (ME), identified as a new clinical entity with distinctive features in 1956, was originally considered as a neuromuscular disease. In 1988 the Centers for Disease Control and Prevention introduced the ill-defined concept of chronic fatigue syndrome (CFS). As predicted, CFS, unjustly considered to be a synonym for ME, pushed ME to the background. Read More

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September 2018

Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function.

PLoS One 2018 11;13(9):e0203503. Epub 2018 Sep 11.

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.

Host-microbe interactions have been implicated in the pathogenesis of chronic fatigue syndrome (CFS), but whether the oral microbiome is altered in CFS patients is unknown. We explored alterations of the oral microbiome in Chinese Han CFS patients using 16S rRNA gene sequencing and alterations in the functional potential of the oral microbiome using PICRUSt. We found that Shannon and Simpson diversity indices were not different in CFS patients compared to healthy controls, but the overall oral microbiome composition was different (MANOVA, p < 0. Read More

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September 2018
12 Reads

Confirmatory factor analysis of a myalgic encephalomyelitis and chronic fatigue syndrome stigma scale.

J Health Psychol 2018 Sep 5:1359105318796906. Epub 2018 Sep 5.

DePaul University, USA.

This study adapted a chronic illness stigma scale and explored its psychometric properties. The main purposes were to confirm the factor structure of the instrument with this population and address the previous factor intercorrelation discrepancies. Five hundred and fifty-four individuals with myalgic encephalomyelitis or chronic fatigue syndrome completed the adapted stigma scale. Read More

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September 2018

Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe-the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review.

BMJ Open 2018 Sep 4;8(9):e020817. Epub 2018 Sep 4.

August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia.

Introduction: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease involving central nervous system and immune system disorders, as well as cardiovascular abnormalities. ME/CFS is characterised by severe chronic fatigue lasting for at least 6 months, including clinical symptoms such as tender cervical or axillary lymph nodes, muscle pain, joint pain without swelling or redness, post-exertional malaise for more than 24 hours and unrefreshing sleep. Studies on the epidemiology of ME/CFS in Europe only include single countries and, therefore, the prevalence and incidence of ME/CFS in Europe (as a whole) is unknown. Read More

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September 2018
3 Reads

Effectiveness of cognitive-behavioral therapy (CBT) in improving the quality of life and psychological fatigue in women with polycystic ovarian syndrome: a randomized controlled clinical trial.

J Psychosom Obstet Gynaecol 2018 Sep 3:1-11. Epub 2018 Sep 3.

d Obstetrics and Gynecology Specialist , Imam Khomeini Hospital , Saqez , Iran.

Introduction: Given the increasing prevalence of complications caused by the polycystic ovarian syndrome (PCOS) such as medical and psychological problems and also the chronicity of this disease, patients with the PCOS tend to experience lower quality of life and greater psychological fatigue similar to other patients with chronic diseases. This study was conducted to determine the effects of cognitive-behavioral therapy (CBT) on the quality of life and psychological fatigue in women with the PCOS.

Methods: This randomized controlled clinical trial study, conducted from 2016 to 2017, enrolled 74 women aged between 18 and 35 years from the Iranian city of Saqqez. Read More

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September 2018

Visual Aspects of Reading Performance in Myalgic Encephalomyelitis (ME).

Front Psychol 2018 17;9:1468. Epub 2018 Aug 17.

Department of Neuroscience, Psychology and Behaviour, College of Life Sciences, University of Leicester, Leicester, United Kingdom.

People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) report vision-related reading difficulty, although this has not been demonstrated objectively. Accordingly, we assessed reading speed and acuity, including crowded acuity and acuity for isolated words using standardized tests of reading and vision, in 27 ME/CFS patients and matched controls. We found that the ME/CFS group exhibited slower maximum reading speed, and had poorer crowded acuity than controls. Read More

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Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence: a qualitative study.

BMJ Paediatr Open 2018 23;2(1):e000299. Epub 2018 Aug 23.

Centre for Child and Adolescent Health, Bristol Medical School, University of Bristol, Bristol, UK.

Background: Adolescents are increasingly using online resources for health purposes. Previous studies suggest that online provision of information about chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is neither balanced nor consistent with evidence-based practice. However, little is known about how adolescents with CFS/ME use the internet for their condition and whether this is helpful or harmful. Read More

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Pediatric-onset multiple sclerosis is associated with reduced parental health-related quality of life and family functioning.

Mult Scler 2018 Aug 30:1352458518796676. Epub 2018 Aug 30.

Division of Child Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Diagnosis of multiple sclerosis (MS) during childhood has the potential to impact the affected child's self-perception and the health-related quality of life (HRQoL) of the family.

Objective: To evaluate the impact of chronic disease, in children ascertained as having MS and their families, when compared to those with monophasic acquired demyelinating syndrome (monoADS).

Methods: In a national prospective cohort study of pediatric acquired demyelinating syndromes (ADS), the HRQoL of children and their families was captured using the Pediatric Quality of Life Inventory (PedsQL) Modules. Read More

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August 2018
2 Reads

A Concurrent Cognitive Task Does Not Perturb Quiet Standing in Fibromyalgia and Chronic Fatigue Syndrome.

Pain Res Manag 2018 7;2018:9014232. Epub 2018 Aug 7.

Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background And Objectives: Cognitive complaints are common in fibromyalgia (FM) and chronic fatigue syndrome (CFS). Fatigue as well as pain may require greater effort to perform cognitive tasks, thereby increasing the load on processing in the central nervous system and interfering with motor control.

Methods: The effect of a concurrent arithmetic cognitive task on postural control during quiet standing was investigated in 75 women (aged 19-49 years) and compared between FM, CFS, and matched controls (=25/group). Read More

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August 2018
3 Reads

Ankylosing spondylitis, chronic fatigue and depression improved after stromal vascular fraction treatment for osteoarthritis: a case report.

J Med Case Rep 2018 Aug 29;12(1):238. Epub 2018 Aug 29.

Macquarie Stem Cells, 21b Bathurst Street, Liverpool, NSW, 2170, Australia.

Background: Osteoarthritis is a prevalent chronic disease that impacts quality of life and imposes a heavy economic burden. Despite this there is no confirmed treatment that could prevent progressive destruction of osteoarthritic joints. Mesenchymal stem cells with their regenerative and immunosuppressive properties have emerged as a potential therapy. Read More

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August 2018
6 Reads

Chronic fatigue syndrome and the somatic expression of emotional distress: Applying the concept of illusory mental health to address the controversy.

J Clin Psychol 2018 Aug 28. Epub 2018 Aug 28.

Veritas Foundation for Clinical Research, Topeka, Kansas.

Objective: The process of somatization in chronic fatigue syndrome (CFS) was investigated using the concept of illusory mental health (IMH). IMH involves self-reporting low emotional distress alongside performance-based assessment of distress.

Method: We studied IHM and physical symptoms in 175 women across four groups: (a) CFS plus depression; (b) CFS with no depression (CFS-ND); (c) depressive disorder without CFS; and (d) healthy controls (HC). Read More

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The effect of physiotherapy on fatigue and physical functioning in chronic fatigue syndrome patients: A systematic review.

Clin Ter 2018 Jul-Aug;169(4):e184-e188

Department of Health Professions, Policlinico "Tor Vergata" of Rome, Italy.

Objective: The objectives of this work were to fill the gap in the scientific literature and to evaluate the results of physical therapy treatments in individuals affected by chronic fatigue syndrome, considering only studies that employed a randomized controlled trial.

Methods: A systematic review was carried out according to PRISMA guidelines. Three bibliographic databases were searched: MEDLINE, Cochrane Library, and PEDro. Read More

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Aluminum in vaccines: Does it create a safety problem?

Vaccine 2018 09 20;36(39):5825-5831. Epub 2018 Aug 20.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy. Electronic address:

For almost a century, aluminum (Al) in the form of Al oxyhydroxide (a crystalline compound), Al hydroxyphosphate (an amorphous Al phosphate hydroxide), Al phosphate, and Al potassium sulfate has been used to improve the immunogenicity of vaccines. Al is currently included in vaccines against tetanus, hepatitis A, hepatitis B, human papillomavirus, Haemophilus influenzae type b, and infections due to Streptococcus pneumoniae and Neisseria meningitidis. Official health authorities consider the inclusion of Al in most of the presently recommended vaccines to be extremely effective and sufficiently safe. Read More

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September 2018
4 Reads

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

Mol Med 2018 Aug 14;24(1):44. Epub 2018 Aug 14.

School of Medical Science, Griffith University, Gold Coast, QLD, Australia.

Background: Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune cell, responsible for recognising and inducing apoptosis of tumour and virus infected cells. Calcium is an essential component in mediating this cellular function. Read More

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August 2018
3 Reads

Chronic fatigue syndrome and quality of life.

Authors:
Deb Roberts

Patient Relat Outcome Meas 2018 1;9:253-262. Epub 2018 Aug 1.

Liverpool CFS Therapy Service, Royal Liverpool and Broadgreen University Hospitals, Liverpool, UK,

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a challenging long-term condition (LTC) with complex and fluctuating symptoms. It is heterogeneous in presentation without diagnostic indicators; therefore, in health care encounters, insight must be gained from the patient's perspective. One indicator of impact can be gained by measuring quality of life (QoL). Read More

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The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome.

J Transl Med 2018 Aug 17;16(1):231. Epub 2018 Aug 17.

Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating disease with huge social-economic impact. It has been suggested that immune dysregulation, nitrooxidative stress, and metabolic impairment might contribute to disease pathogenesis. However, the etiology of ME/CFS remains largely unclear, and diagnostic/prognostic disease markers are lacking. Read More

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August 2018
3 Reads

Illness beliefs of adolescents with CFS and their parents: the perceived causes of illness and beliefs about recovery.

Int J Adolesc Med Health 2018 Aug 17. Epub 2018 Aug 17.

Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Weston Education Centre, Cutcombe Road, London, SE5 9RJ, UK.

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August 2018
5 Reads

Cytotoxic Profiling of Endogenous Metabolites Relevant to Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) on p53 Variant Human Colon Carcinoma Cell Lines.

Dose Response 2018 Jul-Sep;16(3):1559325818790999. Epub 2018 Aug 9.

Department of Biology, McMaster University, Hamilton, Canada.

Chemoprophylatic strategies against development of multifactorial diseases utilize compounds to block the multistep events in chronic inflammation and carcinogenesis. The successful chemopreventative candidate must therefore selectively inhibit growth of transformed cells and be administered frequently to confer maximal protection with minimal side effects. In addition to synthetic and exogenous natural compounds, endogenous metabolites represent another class of compounds that exhibit anticarcinogenic and anti-inflammatory properties contributing to proper cell function. Read More

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August 2018
3 Reads

Home-based family focused rehabilitation for adolescents with severe Chronic Fatigue Syndrome.

Clin Child Psychol Psychiatry 2018 Aug 16:1359104518794764. Epub 2018 Aug 16.

3 Department of Psychological Medicine, Institute of Psychology, Psychiatry and Neuroscience, King's College London, UK.

Aims: The purpose of this article is to describe and evaluate a home based, family focused rehabilitative approach for severely affected housebound adolescents with Chronic Fatigue Syndrome (CFS). The main aims were to facilitate a return to school, improve physical functioning, reduce fatigue and assess any adverse effects of the intervention.

Methods: Six housebound adolescents aged 11-18, diagnosed with CFS by a paediatrician, were assessed and treated at home by an experienced cognitive behaviour therapist. Read More

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Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome.

Fatigue 2018 12;6(2):80-91. Epub 2018 Jan 12.

Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington, USA.

Background: Chronic fatigue syndrome (CFS) is characterized by prolonged fatigue and other physical and neurocognitive symptoms. Some studies suggest that CFS is accompanied by disruptions in the number and function of various lymphocytes. However, it is not clear which lymphocytes might influence CFS symptoms. Read More

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January 2018
2 Reads

Biopsychosocial predictors and trajectories of work participation after transdiagnostic occupational rehabilitation of participants with mental and somatic disorders: a cohort study.

BMC Public Health 2018 Aug 15;18(1):1014. Epub 2018 Aug 15.

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: Group-based transdiagnostic occupational rehabilitation programs including participants with mental and somatic disorders have emerged in clinical practice. Knowledge is sparse on subsequent participation in competitive work. This study aimed to investigate trajectories for (re)entry to work for predefined subgroups in a diagnostically heterogeneous sample of sick-listed participants after completing occupational rehabilitation. Read More

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August 2018
2 Reads

The association between the prevalence of restless leg syndrome, fatigue, and sleep quality in patients undergoing hemodialysis.

Saudi Med J 2018 Aug;39(8):792-798

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hitit University, Corum, Turkey. E-mail.

Objective: To determine the prevalence of restless legs syndrome (RLS) in patients with chronic renal failure (CRF) and to compare CRF patients with or without RLS in terms fatigue and sleep quality.

Methods: A cross-sectional study was conducted on 220 patients (18-75 years) who were undergoing dialysis 3 times weekly in Çorum Province, Corum, Turkey, between January 2014 and January 2016. The diagnosis of RLS was based on the diagnostic form proposed by the international RLS study group. Read More

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August 2018
2 Reads

The associated features of multiple somatic symptom complexes.

J Psychosom Res 2018 Sep 12;112:1-8. Epub 2018 Jun 12.

Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, UK.

Objective: To assess whether two or more functional somatic symptom complexes (SSCs) showed stronger association with psychosocial correlates than single or no SSC after adjustment for depression/anxiety and general medical disorders.

Methods: In a population-based sample we identified, by standardised questionnaire, participants with chronic widespread pain, chronic fatigue and irritable bowel syndrome, excluding those with a medical cause for pain/fatigue. We compared psychosocial variables in three groups: multiple (>1), single or no FSS, adjusting for depression/anxiety and general medical disorders using ordinal logistic regression. Read More

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September 2018
2 Reads

Multidisciplinary rehabilitation treatment is not effective for myalgic encephalomyelitis/chronic fatigue syndrome: A review of the FatiGo trial.

Health Psychol Open 2018 Jul-Dec;5(2):2055102918792648. Epub 2018 Aug 6.

Independent Researcher, Germany.

The FatiGo trial concluded that multidisciplinary rehabilitation treatment is more effective for chronic fatigue syndrome/myalgic encephalomyelitis in the long term than cognitive behaviour therapy and that multidisciplinary rehabilitation treatment is more cost-effective for fatigue and cognitive behaviour therapy for quality of life. However, FatiGo suffered from a number of serious methodological flaws. Moreover, it ignored the results of the activity metre, its only objective outcome. Read More

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Dry eye syndrome and the subsequent risk of chronic fatigue syndrome-a prospective population-based study in Taiwan.

Oncotarget 2018 Jul 17;9(55):30694-30703. Epub 2018 Jul 17.

Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Background And Aim: The clinical association between dry eye syndrome (DES) and chronic fatigue syndrome (CFS) remain unclear with less evidences. We aimed to investigate the relationship between CFS and DES using a national insurance and prospective cohort study.

Methods: Data from the Longitudinal Health Insurance Database 2000 was applied to estimate the incidence of CFS among patients with DES, and their age- and sex-matched controls without DES over a long-term follow-up period. Read More

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July 2018
4 Reads

Health-related quality of life in children with PFAPA syndrome.

Orphanet J Rare Dis 2018 Aug 9;13(1):132. Epub 2018 Aug 9.

CEREMAIA, departement of pediatrics, Versailles hospital, Versailles Le Chenay, France.

Background: Conventionally, PFAPA syndrome is considered as a benign disease compared to other recurrent fevers because it completely passes before adulthood. However, in our clinical practice, fever episodes have a huge impact on daily activities.

Methods: Observational cohort study using the Pediatric Quality of Life Inventory (PedsQL™ 4. Read More

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August 2018
1 Read

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Zhen Ci Yan Jiu 2018 Jun;43(6):335-40

Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.

Objective: To observe the effect of electroacupuncture (EA) of "Zusanli" (ST 36) on mitochondrial oxidative stress of skeletal muscle in rats with chronic fatigue syndrome (CFS) based on adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/ peroxlsome proliferator-activated receptor-γ coactivator-1 α (PGC-1 α) signaling, in order to reveal its mechanism underlying improvement of CFS.

Methods: Forty SD rats were randomly divided into normal control, CFS model, EA-Zusanli (ST 36) and EA-non-acupoint groups (=10 rats in each group). The CFS model was established by forced exhausted load-bearing swimming (twice daily), chronic constraint (1 h) and sleep deprivation (20 h/day) for 14 days. Read More

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June 2018
1 Read

DVT Intervention in the Post-ATTRACT Era.

Curr Treat Options Cardiovasc Med 2018 Aug 6;20(9):70. Epub 2018 Aug 6.

Department of Radiology, Division of Interventional Radiology, New York University-Langone School of Medicine, 660 1st Avenue, Room 318, New York, NY, 10016, USA.

Purpose Of Review: Patients suffering from acute lower extremity deep vein thrombosis (DVT) are at risk for developing chronic limb pain, heaviness, and fatigue, known as the post-thrombotic syndrome (PTS).

Recent Findings: Although several studies have shown that catheter-directed therapy reduces clot burden and may improve clinical outcomes, the multicenter randomized controlled ATTRACT trial showed no difference in PTS or quality of life at 2 years between patients treated with pharmacomechanical catheter-directed thrombolysis (PCDT) and those treated with anticoagulation alone, and a higher major bleeding rate in the PCDT group. PCDT is not indicated for most patients diagnosed with lower extremity DVT. Read More

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August 2018
2 Reads

Dimensional Personality Assessment among a Chronic Fatigue Syndrome (CFS) sample with Personality Inventory for DSM-5 (PID-5).

Actas Esp Psiquiatr 2018 Jul 1;46(4):125-32. Epub 2018 Jul 1.

Psychiatry Department, Sant Rafael Hospital, Barcelona, Spain.

Introduction: Personality Disorders (PD) are highly prevalent among Chronic Fatigue Syndrome (CFS) patients, but studies based on the DSM-5 are still scarce. Validated instruments have not yet been specifically used in CFS patients. Therefore, our aim was to analyze the differences in personality facets and domains profiles among CFS patients with and without a PD using the Personality Inventory for DSM-5 (PID-5). Read More

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July 2018
2 Reads

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

J Pharmacol Exp Ther 2018 Oct 3;367(1):155-167. Epub 2018 Aug 3.

Second Department of Internal Medicine, Attikon General Hospital, Athens Medical School, Athens, Greece (E.H., M.A., G.D.); Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology (I.T., T.C.T.) and Sackler School of Graduate Biomedical Sciences (T.C.T.), Tufts University School of Medicine, Boston, Massachusetts; and Departments of Internal Medicine and Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts (T.C.T.)

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by debilitating fatigue, lasting for at least 6 months, with associated malaise, headaches, sleep disturbance, and cognitive impairment, which severely impacts quality of life. A significant percentage of ME/CFS patients remain undiagnosed, mainly due to the complexity of the disease and the lack of reliable objective biomarkers. ME/CFS patients display decreased metabolism and the severity of symptoms appears to be directly correlated to the degree of metabolic reduction that may be unique to each individual patient. Read More

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October 2018
8 Reads

Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation.

PLoS One 2018 1;13(8):e0201488. Epub 2018 Aug 1.

Department of Psychology, University of Jaén, Jaén, Spain.

Background: Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain and diffuse tenderness, accompanied by complaints including morning stiffness, fatigue, insomnia and affective symptoms. In addition, affected patients frequently experience cognitive impairments such as concentration difficulties, forgetfulness or problems in planning and decision-making. These deficits are commonly ascribed to interference between nociceptive and cognitive processing. Read More

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August 2018
1 Read

Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls.

Nord J Psychiatry 2018 Jul 31:1-5. Epub 2018 Jul 31.

a Department of Mental Health, Faculty of Medicine and Health Sciences , Norwegian University of Science and Technology (NTNU) , Trondheim , Norway.

Purpose: The reports regarding the status of the immune system in patients with chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) have been inconclusive. We approached this question by comparing a strictly defined group of CFS/ME outpatients to healthy control individuals, and thereafter studied cytokines in subgroups with various psychiatric symptoms.

Materials And Methods: Twenty patients diagnosed with CFS/ME according to the Fukuda criteria and 20 age- and sex-matched healthy controls were enrolled in the study. Read More

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July 2018
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Antifatigue Potential Activity of in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Oxid Med Cell Longev 2018 28;2018:9140896. Epub 2018 Jun 28.

School of Life Sciences, Jilin University, Changchun 130012, China.

(SI), a precious edible fungus, contains 35.22% of total sugar, 18.33% of total protein, 24 types of fatty acid, 16 types of amino acid, and 8 types of minerals. Read More

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An observational study of headaches in children and adolescents with functional abdominal pain: Relationship to mucosal inflammation and gastrointestinal and somatic symptoms.

Medicine (Baltimore) 2018 Jul;97(30):e11395

Division of Developmental and Behavioral Sciences, Children's Mercy Kansas City, Kansas City, MO.

Headaches and abdominal pain are among the most common pediatric pain conditions. Mast cells have been implicated in the pathophysiology of migraines, as well as functional dyspepsia (FD) and irritable bowel syndrome (IBS). The primary aims of the current study were to assess headache prevalence in patients with FD and to assess the association between headaches and mucosal mast cells and eosinophils. Read More

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July 2018
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How chronic administration of benzodiazepines leads to unexplained chronic illnesses: A hypothesis.

Authors:
S LaCorte

Med Hypotheses 2018 Sep 20;118:59-67. Epub 2018 Jun 20.

Benzodiazepine Information Coalition, 1042 Fort Union Blvd. Suite 1030, Midvale, UT 84047, United States. Electronic address:

It is thought that an ill defined biochemical cascade may lead to protracted withdrawal symptoms subsequent to discontinuance of routine use of benzodiazepine class drugs and establish chronic illness in some patients. In this review, published findings are presented that support the novel concept that withdrawal from benzodiazepine class drugs can trigger elevated and sustained levels of a potent oxidant called peroxynitrite via potentiation of the L-type voltage-gated calcium channels, and in the later stages of withdrawal, via excessive N-methyl-D-aspartate receptor activity, as well. Potentiation of L-type voltage-gated calcium channels and excessive N-methyl-D-aspartate receptor activity both result in calcium influx into the cell that triggers nitric oxide synthesis. Read More

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September 2018
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Spinal fluid evacuation may provide temporary relief for patients with unexplained widespread pain and fibromyalgia.

Med Hypotheses 2018 Sep 20;118:55-58. Epub 2018 Jun 20.

Clinical Electromyography Laboratory, University Hospitals UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.

Fibromyalgia (FM) exhibits characteristics of a neurological disorder, and similarities have been identified between FM and idiopathic intracranial hypertension (IICH). When intracranial pressure rises, the drainage of excess cerebrospinal fluid (CSF) through the subarachnoid space of the cranial and spinal nerves increases. Higher CSF pressure irritates nerve fibers inside nerve root sheaths and may consequently cause radicular pain, as was reported in patients with IICH. Read More

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September 2018
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