16,868 results match your criteria Chronic Bronchitis

Analysis of Microbiological and Clinical Characteristics of Bacterial Infection in Patients with Pulmonary Infection.

Taimei Duan

Comput Intell Neurosci 2022 16;2022:5607358. Epub 2022 Jun 16.

The First People's Hospital of Chongqing Liangjiang New Area, Chongqing 401121, China.

Objective: Using data investigation, the microbiology of bacterial infection in patients with pulmonary infection was discussed, and its clinical characteristics were analyzed.

Methods: The clinical data of 160 patients with pulmonary infection in our hospital from March 2019 to March 2021 were collected and analyzed. Blood samples were collected and cultured, and the pathogens were identified. Read More

View Article and Full-Text PDF

Evaluation of the multimorbidity network and its relationship with clinical phenotypes in chronic obstructive pulmonary disease: The GALAXIA study.

Clin Respir J 2022 Jun 22. Epub 2022 Jun 22.

Pneumology and Thoracic Surgery Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Background: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous condition, in which taking into consideration clinical phenotypes and multimorbidity is relevant to disease management. Network analysis, a procedure designed to study complex systems, allows to represent connections between the distinct features found in COPD.

Methods: Network analysis was applied to a cohort of patients with COPD in order to explore the degree of connectivity between different diseases, taking into account the presence of two phenotypic traits commonly used to categorize patients in clinical practice: chronic bronchitis (CB /CB ) and the history of previous severe exacerbations (Ex /Ex ). Read More

View Article and Full-Text PDF

[Influence of age of patients with bronchopulmonary pathology on low-molecular DNA concentration in blood plasma.]

Adv Gerontol 2022 ;35(2):281-286

N.N.Petrov National Medical Research Center of Oncology, 68 Leningradskaya str., Pesochnyi, St. Petersburg 197758, Russian Federation, e-mail:

The aim of the work was to determine the concentration of low-molecular-weight plasma DNA (lmDNA) in patients with COPD and chronic non-obstructive bronchitis (CnonB) of two age groups - 34-59 and 60-80 years. The levels of lmDNA in healthy donors, patients with CnonB, healthy relatives of patients with COPD did not differ, while the concentration of lmDNA in patients with COPD was significantly lower. In COPD patients aged 34-59 years, the level of lmDNA was reduced by more than 7 times, and in COPD patients who survived to 60-80 years, it was 3 times lower compared to the value of this biochemical indicator in healthy donors of the same age. Read More

View Article and Full-Text PDF

Childhood 'bronchitis' and respiratory outcomes in middle-age: a prospective cohort study from age 7 to 53 years.

BMJ Open Respir Res 2022 06;9(1)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Chronic bronchitis in childhood is associated with a diagnosis of asthma and/or bronchiectasis a few years later, however, consequences into middle-age are unknown.

Objective: To investigate the relationship between childhood bronchitis and respiratory-related health outcomes in middle-age.

Design: Cohort study from age 7 to 53 years. Read More

View Article and Full-Text PDF

Contribution of smoking change to 45-year trend in prevalence of chronic bronchitis in Finland.

Scand J Public Health 2022 Jun 19:14034948221104351. Epub 2022 Jun 19.

Department of Public Health and Welfare, Finnish institute for Health and Welfare, Helsinki, Finland.

Aims: Tobacco smoking has been identified as the most important risk factor of chronic bronchitis. The aim of this study was to assess the contribution of smoking to the trends in prevalence of chronic bronchitis among men and women in Finland.

Methods: For this purpose, we analysed questionnaires included in national FINRISK and FinHealth studies conducted between 1972 and 2017 in 5-year intervals. Read More

View Article and Full-Text PDF

Inflammatory response in human lung cells stimulated with plasma from COPD patients.

Multidiscip Respir Med 2022 Jan 24;17:817. Epub 2022 May 24.

Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville.

Background: Chronic obstructive pulmonary disease (COPD) is a condition resulting from a persistent inflammatory state in the airways even after smoking cessation. Intriguingly, the reasons behind this persistence of the inflammatory influx without smoking exposure have not been fully unraveled. We aimed to explore the hypothesis that systemic inflammation in COPD patients influences lung cell inflammatory response. Read More

View Article and Full-Text PDF
January 2022

Azotobacter chroococcum and Pseudomonas putida enhance pyrroloquinazoline alkaloids accumulation in Adhatoda vasica hairy roots by biotization.

J Biotechnol 2022 Jul 10;353:51-60. Epub 2022 Jun 10.

Department of Botany, University of Rajasthan, Jaipur 302 004, India.

Adhatoda vasica is used in the treatment of cold, cough, chronic bronchitis, asthma, diarrhea, and dysentery. The biological activities of this species are attributed with the presence of alkaloids, triterpenoids, and flavonoids. Agrobacterium rhizogenes-mediated transformation of A. Read More

View Article and Full-Text PDF

Clinical features and three-year prognosis of AECOPD patients with different levels of blood eosinophils.

Heart Lung 2022 Jun 7;56:29-39. Epub 2022 Jun 7.

Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China.

Background: Eosinophils are thought to be associated with the frequency and severity of acute exacerbations of chronic obstructive pulmonary disease (AECOPD); however, the role of eosinophilic inflammation in AECOPD is still incompletely understood.

Objectives: To investigate the relationship between different levels of blood eosinophils and clinical features, including comorbidities, therapy, and prognosis, and to further explore the optimal eosinophilic cutoff.

Methods: We retrospectively collected and analyzed medical data, laboratory findings, chest CT images, treatment, and three-year follow-up data from 984 AECOPD patients with different blood eosinophil (EOS) levels: EOS%<2%, ≥2%; EOS%<3%, ≥3%; eosinophil counts<100 cells/L, ≥100 cells/L. Read More

View Article and Full-Text PDF

Serum antioxidant vitamins and respiratory morbidity and mortality: a pooled analysis.

Respir Res 2022 Jun 9;23(1):150. Epub 2022 Jun 9.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Background: Oxidative stress plays a key role in the pathogenesis of respiratory diseases; however, studies on antioxidant vitamins and respiratory outcomes have been conflicting. We evaluated whether lower serum levels of vitamins A, C, D, and E are associated with respiratory morbidity and mortality in the U.S. Read More

View Article and Full-Text PDF

Characteristics of Oral Mucosal Lesions and Their Association With Socioeconomic Status and Systemic Health: A Cross-Sectional Study of Consecutively Collected Oral Medicine Clinic Data in a Remote Rural Area of China.

Front Public Health 2022 23;10:897814. Epub 2022 May 23.

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: Epidemiological data of oral mucosal lesions (OMLs) are required to develop practical oral care policies. However, limited data are available for rural areas in China. We aimed to estimate the spectrum and frequency of OMLs and to identify their associated socioeconomic status (SES) and systemic health in a remote rural area in Yunnan, China. Read More

View Article and Full-Text PDF

Stakeholder Mapping on the Development of Digital Health Interventions for Self-Management Among Patients with Chronic Obstructive Pulmonary Disease in China.

Stud Health Technol Inform 2022 Jun;290:1106-1107

School of Medicine, Washington University in St. Louis, Saint Louis, the United States.

Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease consisting of chronic bronchitis and emphysema. Digital Health Interventions (DHIs) can improve COPD patients' self-management. However, the market penetration of DHIs is lower than expected. Read More

View Article and Full-Text PDF

Specific antibody deficiency: Pearls and pitfalls for diagnosis.

Ann Allergy Asthma Immunol 2022 Jun 4. Epub 2022 Jun 4.

Department of Medicine - University of Virginia, Charlottesville, Virginia; Department of Microbiology - University of Virginia, Charlottesville, Virginia.

Objective: Specific antibody deficiency is an immune deficiency defined by the presence of normal quantitative levels of immunoglobulins but impaired antibody responses to polysaccharide antigens in patients presenting with frequent otosinopulmonary infections with pyogenic bacteria. This review summarizes the pitfalls associated with defining exactly what constitutes an "impaired" antibody response to polysaccharide antigens and the importance of documenting actual pyogenic infections before making a diagnosis of an immune deficiency.

Data Sources: PubMed review using the following words: specific antibody deficiency, pneumococcal vaccination, salmonella vaccination, infectious sinusitis Study Selection: This review focused on key studies that have been utilized to define what constitutes a "normal" humoral immune response to pneumococcal and salmonella vaccination in healthy subjects as well as published papers defining current expert opinion. Read More

View Article and Full-Text PDF

Contemporary Concise Review 2021: COVID-19 and other respiratory infections.

Respirology 2022 Jun 7. Epub 2022 Jun 7.

Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Bats are likely the primary source of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Minks are highly susceptible to infection by SARS-CoV-2. Transmission from asymptomatic individuals was estimated to account for over 50% of all transmissions of coronavirus disease 2019 (COVID-19) cases. Read More

View Article and Full-Text PDF

Serum C-reactive protein-to-albumin ratio is a potential risk indicator for pneumonia: Findings from a prospective cohort study.

Respir Med 2022 08 29;199:106894. Epub 2022 May 29.

Central Finland Health Care District Hospital District, Department of Medicine, Finland District, Jyväskylä, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland.

Objective: Circulating C-reactive protein (CRP) and albumin are known biomarkers of systemic inflammation. C-reactive protein-to-albumin ratio (CAR), a novel biomarker, has been suggested to be a more reliable risk indicator for inflammatory conditions compared to CRP or albumin alone. Inflammatory processes underlie the pathophysiology of pneumonia, but the association between CAR and pneumonia has not been previously investigated. Read More

View Article and Full-Text PDF

Role of Socioeconomic Factors on Physical and Mental Distress Reported by Alabama Adults with COPD.

South Med J 2022 Jun;115(6):374-380

From the Department of Health Science, the Capstone College of Nursing, the College of Arts and Sciences, and the College of Education, The University of Alabama, Tuscaloosa, and the Department of Behavioral and Community Health, University of Maryland, College Park.

Objectives: Educational attainment, income, and race play significant roles in managing and treating patients with chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the impact of these socioeconomic factors and others on the physical and mental distress reported by patients with COPD living in Alabama.

Methods: A cross-sectional analysis was completed of Alabama Behavioral Risk Factor Surveillance System 2015-2019 data collected from 4123 respondents who reported that a health professional told them they had COPD, chronic bronchitis, or emphysema. Read More

View Article and Full-Text PDF

Endoscopic Options for Moderate COPD, Chronic Bronchitis, and Uncontrolled Asthma.

Semin Respir Crit Care Med 2022 Jun 1. Epub 2022 Jun 1.

Department of Pneumology and Critical Care Medicine, Thoraxklinik and, Heidelberg, Germany.

Until now, interventional therapies for patients with chronic obstructive pulmonary disease have been available in the form of lung volume reduction procedures as end-stage options. Currently, the range of indications is expanding to include earlier stages of the diseases. Lung denervation is available for moderate COPD, and patients with chronic bronchitis are being evaluated for endoscopic goblet cell ablation. Read More

View Article and Full-Text PDF

Developing lung cancer in COPD: Possible role of carrying Alpha-1 antitrypsin deficiency variants.

Respir Med Case Rep 2022 21;38:101667. Epub 2022 May 21.

Department of Chest Diseases, Health Sciences University, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and airway inflammation, with a prevalence of 10.1%. Among the many causes of COPD, Smoking is the leading and another big cause is (AATD α1-antitrypsin deficiency)' an inherited disorder. Read More

View Article and Full-Text PDF

Effect of COVID-19 on air pollution related illnesses in India.

Ann Med Surg (Lond) 2022 Jun 26;78:103871. Epub 2022 May 26.

Karachi Medical and Dental College, Karachi, Pakistan.

Ambient air pollution level not only causes respiratory diseases but also cardiovascular diseases, besides, increased visits to the emergency department for asthma, chronic obstructive pulmonary disease (COPD), bronchitis, allergic rhinitis, attention deficit hyperactivity disorder (ADHD) in children and premature deaths in infants. The occurrence of Coronavirus-19 (COVID-19) pandemic is both, a boon and bane. Despite the deplorable situation aroused by the pandemic, strict lockdown measures implemented to curb the drastic spread of the disease, also culminated into astonishing outcomes that were not prioritized. Read More

View Article and Full-Text PDF

Complex Presentation of Hao-Fountain Syndrome Solved by Exome Sequencing Highlighting Co-Occurring Genomic Variants.

Genes (Basel) 2022 May 16;13(5). Epub 2022 May 16.

Area di Ricerca Genetica e Malattie Rare, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146 Rome, Italy.

Objective: The co-occurrence of pathogenic variants has emerged as a relatively common finding underlying complex phenotypes. Here, we used whole-exome sequencing (WES) to solve an unclassified multisystem clinical presentation.

Patients And Methods: A 20-year-old woman affected by moderate intellectual disability (ID), dysmorphic features, hypertrichosis, scoliosis, recurrent bronchitis, and pneumonia with bronchiectasis, colelithiasis, chronic severe constipation, and a family history suggestive of autosomal dominant recurrence of polycystic kidney disease was analyzed by WES to identify the genomic events underlying the condition. Read More

View Article and Full-Text PDF

Urinary metals, arsenic, and polycyclic aromatic hydrocarbon exposure and risk of chronic bronchitis in the US adult population.

Environ Sci Pollut Res Int 2022 May 27. Epub 2022 May 27.

Data Forward Analytics, LLC, 4973 Black Quartz Road, PrincipalLas Cruces, NM, 88011, USA.

Metals, arsenic, and polycyclic aromatic hydrocarbons (PAHs) have all been linked to respiratory diseases. Chronic bronchitis, which is a form of chronic obstructive pulmonary disease (COPD), is a major public health concern and source of morbidity and mortality in the US. The purpose of this study was to analyze the correlation of 14 urinary metals (antimony, barium, cadmium, cesium, cobalt, lead, manganese, mercury, molybdenum, strontium, thallium, tin, tungsten, uranium), seven species of arsenic, and seven forms of polycyclic aromatic hydrocarbon (PAH) concentrations and chronic bronchitis in the US population. Read More

View Article and Full-Text PDF

Prevalence of Chronic Obstructive Pulmonary Disease and Chronic Bronchitis Among Predominantly Smoking Workers in the Seafood Industry in Greenland.

Int J Chron Obstruct Pulmon Dis 2022 20;17:1167-1177. Epub 2022 May 20.

Department of Occupational and Environmental Medicine, Danish Ramazzini Centre, Aalborg University Hospital, Aalborg, Denmark.

Introduction: For decades, the prevalence of smoking has been high in Greenland. Even so, the prevalence of chronic obstructive pulmonary disease (COPD), a smoking-related disease, remains largely unexplored. This cross-sectional study aimed to estimate the prevalence of COPD and chronic bronchitis (CB) among Inuit workers in the seafood industry in Greenland. Read More

View Article and Full-Text PDF

Inhaled Marijuana and the Lung.

J Allergy Clin Immunol Pract 2022 May 21. Epub 2022 May 21.

Division of Respiratory Medicine, Department of Medicine, University of British Columbia, V6Z 1Y6, Canada.

Although vaping has recently increased as a mode of inhaling marijuana and has been associated with numerous and sometimes fatal cases of acute severe lung injury, smoking remains the most common method of inhaling marijuana and has been studied more extensively. Smoking marijuana has been shown to produce modest but significant short-term bronchodilation both in healthy subjects and those with asthma. Long-term effects of habitual marijuana smoking include the following: 1) symptoms of chronic bronchitis (increased cough, sputum production and wheezing); 2) modest effects on lung function in cross-sectional studies (no significant decrease in forced expired volume in 1 second [FEV) but mild reductions in FEV/forced vital capacity ratio [FEV/FVC], an increase in FVC and other lung volumes, reductions in specific airway conductance, and variable effects of maximal mid-expiratory flow rates and diffusing capacity; and 3) variable effects on age-related decline in FEV1 in longitudinal studies. Read More

View Article and Full-Text PDF

The Changing Definition and Perception of COPD.

David M Mannino

Respir Care 2022 06;67(6):750-755

Department of Medicine, University of Kentucky College of Medicine, Lexington, Kentucky.

COPD remains one of the leading causes of death worldwide. The impact of smoking and air pollution remain important causative factors. Traditional classification of COPD includes the overlap of emphysema, chronic bronchitis and asthma. Read More

View Article and Full-Text PDF

Health Concerns of Textile Workers and Associated Community.

Tanweer Islam

Inquiry 2022 Jan-Dec;59:469580221088626

National University of Sciences and Technology, Islamabad, Pakistan.

Background: Workers in the textile industry risk developing various respiratory and pulmonary diseases due to exposure to cotton dust. The particles from the cotton lint are inhaled by the workers and results in the breathing problems including asthma, shortness of breath, cough and tightness in the chest. The poor health of labor contributes to the low productivity of the labor and in serious cases loss of jobs leading to the poverty. Read More

View Article and Full-Text PDF

Dietary habits, cardiovascular and other causes of death in a practically extinct cohort of middle-aged men followed-up for 61 years.

Nutr Metab Cardiovasc Dis 2022 Apr 19. Epub 2022 Apr 19.

Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy.

Background And Aim: To test a dietary score produced from individual data of middle-aged-men enrolled in 1960 based on an a-posteriori approach and to study its association with some specific causes of death during 61 years until their practical extinction.

Methods And Results: In 1960 the Italian Rural Areas of the Seven Countries of Cardiovascular Diseases were enrolled and 1712 men aged 40-59 were examined with measurement of several risk factors and the collection of dietary history. Using 18 food groups a factor score was obtained from a Principal Component Analysis, that was divided into three classes, arbitrarily called non-Mediterranean, Intermediate and Mediterranean diets. Read More

View Article and Full-Text PDF

The ethanolic extract of Artemisia anomala exerts anti-inflammatory effects via inhibition of NLRP3 inflammasome.

Phytomedicine 2022 Jul 10;102:154163. Epub 2022 May 10.

Laboratory of Natural Product Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, PR China.

Background: Artemisia anomala S. Moore (Compositae), known as "Nan-Liu-Ji-Nu" in traditional Chinese medicine (TCM), has been used to treat many inflammatory diseases, including enteritis, acute icteric hepatitis, rheumatism, toothache, tonsillitis, and chronic bronchitis, for centuries. Our preliminary studies have demonstrated that the ethanolic extract of A. Read More

View Article and Full-Text PDF

lncRNA GAS5 promotes pyroptosis in COPD by functioning as a ceRNA to regulate the miR‑223‑3p/NLRP3 axis.

Mol Med Rep 2022 Jul 18;26(1). Epub 2022 May 18.

Department of General Practice, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China.

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible and progressive airflow limitation and encompasses a spectrum of diseases, including chronic obstructive bronchitis and emphysema. Pyroptosis is a unique form of inflammatory cell death mediated by the activation of caspase‑1 and inflammasomes. The long non‑coding RNA (lncRNA) growth arrest‑specific 5 (GAS5) is a well‑documented tumor suppressor, which is associated with cell proliferation and death in various diseases. Read More

View Article and Full-Text PDF

Persistent asthma hospitalisations and deaths require a national asthma prevention plan.

Intern Emerg Med 2022 Jun 17;17(4):953-955. Epub 2022 May 17.

Section of Respiratory Diseases, Department of Medicine and Surgery, SMECHIMAI, University of Modena and Reggio Emilia, AOU di Modena Policlinico, Largo del Pozzo 71, 41124, Modena, Italy.

View Article and Full-Text PDF

Advances in inhaled corticosteroids for the treatment of chronic obstructive pulmonary disease: what is their value today?

Expert Opin Pharmacother 2022 Jun 22;23(8):917-927. Epub 2022 May 22.

Unit of Pharmacology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: As of today, there is still a need to determine which COPD patients may benefit from ICS therapy, whether ICSs are useful in COPD patients without chronic bronchitis, and whether long-acting bronchodilators can reduce the risk of exacerbations in frequent exacerbators even if ICSs are not used, and whether combination therapy including ICSs is helpful in infrequent exacerbators to optimize the use of ICSs in COPD.

Areas Covered: Herein, the authors provide an overview of use of ICS in COPD, discuss their value to the current treatment armamentarium and focus on emerged aspects on which there is no consensus.

Expert Opinion: There is growing agreement on why, in whom, and when ICS therapy can be used in COPD, although the consensus is still lacking because of the heterogeneity of COPD. Read More

View Article and Full-Text PDF

Evaluation of Health Hazard and Governance Performance of Air Pollution: A Case Study of Z City.

Ying Cui Yunxia Shi

Front Public Health 2022 25;10:827713. Epub 2022 Apr 25.

School of Management, Shandong Technology and Business University, Yantai, China.

Based on the date of the main pollutant discharge and the change of pollutant concentration in Z city, this study performed the statistical analysis of the concentration data in excel. The data covers 3 years from 1 January 2015 to 31 December 2017. An exposure-response relationship model was used established to evaluate the health hazards caused by air pollution and the corresponding economic losses, further analyzing the relationship between air pollution, health hazards, and economic benefits. Read More

View Article and Full-Text PDF