16,339 results match your criteria Chronic Bronchitis


Smoking Behaviors in Survivors of Smoking-Related and Non-Smoking-Related Cancers.

JAMA Netw Open 2020 Jul 1;3(7):e209072. Epub 2020 Jul 1.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: The population of cancer survivors is rapidly growing in the US. Tobacco smoking is associated with many cancers; however, whether cigarette smoking behaviors among cancer survivors vary according to cancer type-that is, smoking-related cancers (SRCs) vs non-smoking-related cancers (NSRCs)-remains unclear.

Objectives: To examine cigarette smoking prevalence and behaviors (ie, continuing or quitting smoking) among cancer survivors and to compare them between survivors of SRCs and NSRCs. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.9072DOI Listing

Sputum Inflammometry to Manage Chronic Obstructive Pulmonary Disease Exacerbations: Beyond Guidelines.

Tuberc Respir Dis (Seoul) 2020 Jul 18;83(3):175-184. Epub 2020 Jun 18.

Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton and the Department of Medicine, McMaster University, Hamilton, ON, Canada.

Quantitative sputum cytometry facilitates in assessing the nature of bronchitis associated with exacerbations of chronic obstructive pulmonary disease (COPD). This is not assessed in most clinical trials that evaluate the effectiveness of strategies to prevent or to treat exacerbations. While up to a quarter of exacerbations may be associated with raised eosinophil numbers, the vast majority of exacerbations are associated with neutrophilic bronchitis that may indicate airway infections. Read More

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http://dx.doi.org/10.4046/trd.2020.0033DOI Listing

Obesity and Morbidity Risk in the U.S. Veteran.

Healthcare (Basel) 2020 Jun 29;8(3). Epub 2020 Jun 29.

School of Health Administration, Texas State University, San Marcos, TX 78666, USA.

The obesity epidemic in the United States has been well documented and serves as the basis for a number of health interventions across the nation. However, those who have served in the U.S. Read More

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http://dx.doi.org/10.3390/healthcare8030191DOI Listing

Effectiveness and Tolerability of LABA/LAMA Fixed-Dose Combinations Aclidinium/Formoterol, Glycopyrronium/Indacaterol and Umeclidinium/Vilanterol in the Treatment of COPD in Daily Practice - Results of the Non-Interventional DETECT Study.

Int J Chron Obstruct Pulmon Dis 2020 10;15:1335-1347. Epub 2020 Jun 10.

Insaf - Respiratory Research Institute GmbH, Wiesbaden, Germany.

Background: LABA (long-acting β2-agonists) and/or LAMA (long-acting muscarinic antagonists) represent the first treatment options for patients with symptomatic COPD. Although both display different mechanisms of activity, in combination they have a stronger broncho-dilating effect than monotherapy; hence, a combination of both LABA and LAMA is particularly recommended for patients whose symptoms cannot be sufficiently improved by a single active ingredient. To date, only few data have been collected regarding the therapeutic outcomes of approved LABA/LAMA fixed-dose combinations (FDCs) under everyday (real-life) conditions in non-clinical trial settings. Read More

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http://dx.doi.org/10.2147/COPD.S252354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293910PMC

Role of Mucolytics in the Treatment of Chronic Bronchitis or COPD.

Am Fam Physician 2020 Jul;102(1):16-17

Fort Belvoir Community Hospital, For Belvoir, VA, USA.

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Establishment of a mouse model with all four clinical features of eosinophilic bronchitis.

Sci Rep 2020 Jun 29;10(1):10557. Epub 2020 Jun 29.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (Guangzhou Medical University), No. 151 Yanjiang Road, Yuexiu District, Guangzhou, 510120, Guangdong, China.

Eosinophilic bronchitis (EB) is a clinical disease characterized by chronic cough, airway eosinophil infiltration, and responsive to steroid therapy but with the absence of airway hyperreactivity (AHR). This study established an EB mouse model with all the above features. First, 42 mice were divided into 7 groups to investigate the optimal time interval between cough and AHR detections. Read More

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http://dx.doi.org/10.1038/s41598-020-67475-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324364PMC

Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study.

Lancet Respir Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; Beijing Chao-Yang Hospital, Department of Respiratory Medicine, Capital Medical University, Beijing, China. Electronic address:

Background: Small airway dysfunction is a common but neglected respiratory abnormality. Little is known about its prevalence, risk factors, and prognostic factors in China or anywhere else in the world. We aimed to estimate the prevalence of small airway dysfunction using spirometry before and after bronchodilation, both overall and in specific population subgroups; assess its association with a range of lifestyle and environmental factors (particularly smoking); and estimate the burden of small airway dysfunction in China. Read More

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http://dx.doi.org/10.1016/S2213-2600(20)30155-7DOI Listing

[Non - tuberculous mycobacteriosis of the lungs - diagnostic possibilities in the practice of the pulmonologist].

Ter Arkh 2019 Nov 15;91(11):26-31. Epub 2019 Nov 15.

Central TB Research Institute.

Aim Of The Study: Show the possibilities of diagnosing non - tuberculous mycobacteriosis of the lungs (NTML) in the practice of the pulmonologist.

Materials And Methods: A survey of 90 patients with a confirmed diagnosis of non - tuberculous mycobacteriosis of the lungs (NTML) was presented. The diagnosis of pulmonary mycobacteriosis was established in accordance with the criteria proposed in 2007 by the American Thoracic Society and the American Society of Infectious Diseases (ATS/IDRS). Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000306DOI Listing
November 2019

Construction of a hybrid lung model by combining a real geometry of the upper airways and an idealized geometry of the lower airways.

Comput Methods Programs Biomed 2020 Jun 20;196:105613. Epub 2020 Jun 20.

Facultad de Enfermería, Universidad de Oviedo, Instituto Nacional de Silicosis and GRUBIPU-ISPA, Spain. Electronic address:

Background And Objective: Health care costs represent a substantial an increasing percentage of global expenditures. One key component is treatment of respiratory diseases, which account for one in twelve deaths in Europe. Computational simulations of lung airflow have potential to provide considerable cost reduction and improved outcomes. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105613DOI Listing

A Prospective Safety and Feasibility Study of Metered CryoSpray (MCS) for Patients with Chronic Bronchitis in COPD.

Eur Respir J 2020 Jul 2. Epub 2020 Jul 2.

Royal Brompton Hospital, London, UK

Background: No currently approved intervention counteracts airway metaplasia and mucus hypersecretion of Chronic Bronchitis (CB) in COPD. Metered Cryospray (MCS) delivering liquid nitrogen (LN) to the tracheobronchial airways ablates abnormal epithelium and facilitates healthy mucosal regeneration. The objective of this study was to evaluate the feasibility, efficacy and safety of MCS in CB. Read More

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http://dx.doi.org/10.1183/13993003.00556-2020DOI Listing

Development and validation of a bronchoscopically defined bronchitis scoring tool in children.

Pediatr Pulmonol 2020 Jun 25. Epub 2020 Jun 25.

Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia.

Introduction/aim: A validated tool for scoring bronchitis during flexible bronchoscopy (FB) is potentially useful for clinical practice and research. We aimed to develop a bronchoscopically-defined bronchitis scoring system in children (BScore) based on our pilot study.

Methods: Children undergoing FB were prospectively enrolled. Read More

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http://dx.doi.org/10.1002/ppul.24924DOI Listing

A Functional Respiratory Imaging Approach to the Effect of an Oscillating Positive Expiratory Pressure Device in Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2020 4;15:1261-1268. Epub 2020 Jun 4.

Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Wilrijk, Belgium.

Purpose: Chronic obstructive pulmonary disease (COPD) patients are prone to suffer from chronic bronchitis, which ultimately affects their quality of life and overall prognosis. Oscillating positive expiratory pressure (oPEP) devices are designed to aid in the mucus clearance by generating positive pressure pulses in the airways. The main aim of this study was to analyze the impact of a specific oPEP device - Aerobika - on top of standard of care medication in COPD patients' lung dynamics and drug deposition. Read More

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http://dx.doi.org/10.2147/COPD.S242191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280059PMC

Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases.

Int J Mol Sci 2020 Jun 18;21(12). Epub 2020 Jun 18.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.

Introduction: The global burden of chronic airway diseases represents an important public health concern. The role of oxidative stress and inflammation in the pathogenesis of these diseases is well known. The aim of this study is to evaluate the behavior of both inflammatory and oxidative stress biomarkers in patients with chronic bronchitis, current asthma and past asthma in the frame of a population-based study. Read More

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http://dx.doi.org/10.3390/ijms21124339DOI Listing

Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China.

BMJ Open 2020 Jun 21;10(6):e034317. Epub 2020 Jun 21.

Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Subject of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China

Purpose: The Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders.

Participants: The cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district of Shenzhen, China. The baseline data were collected between 2017 and 2018, including demographics and socioeconomics, lifestyles, medical history, family history of major non-communicable chronic disease, environmental exposures, clinical analysis of blood and urine, clinical imaging measurements, anthropometric measures and neurological function and mental health assessments. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307537PMC

Infectious Coryza: Persistence, Genotyping, and Vaccine Testing.

Avian Dis 2020 Jun;64(2):157-165

Foster Farms, Delhi, CA 95315.

The reemergence of infectious coryza (IC) caused by (AP) as an acute and occasionally chronic respiratory disease in domestic poultry has caused severe losses in several U.S. states. Read More

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http://dx.doi.org/10.1637/0005-2086-64.2.157DOI Listing

Effect of acupuncture on chronic bronchitis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(24):e20676

Hospital of Chengdu University of Traditional Chinese Medicine/Clinical Medical College of Chengdu University of Traditional Chinese Medicine.

Introduction: Chronic bronchitis (CB) is a clinically common and recurrent respiratory disease. However, many trials have shown that acupuncture can effectively treat CB. There is currently no systematic review of this therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000020676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302603PMC

The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis.

J Cyst Fibros 2020 Jun 13. Epub 2020 Jun 13.

National Heart and Lung Institute, Imperial College, London SW3 6LY, UK.

Background: The prevalence of fungal disease in cystic fibrosis (CF) and non-CF bronchiectasis is increasing and the clinical spectrum is widening. Poor sensitivity and a lack of standard diagnostic criteria renders interpretation of culture results challenging. In order to develop effective management strategies, a more accurate and comprehensive understanding of the airways fungal microbiome is required. Read More

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http://dx.doi.org/10.1016/j.jcf.2020.05.013DOI Listing

Epilepsy and chronic obstructive pulmonary disease among U.S. adults: National Health Interview Survey 2013, 2015, and 2017.

Epilepsy Behav 2020 Jun 9:107175. Epub 2020 Jun 9.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States.

Background: Among U.S. adults, over 4 million report a history of epilepsy, and more than 15 million report a history of chronic obstructive pulmonary disease (COPD); Chronic obstructive pulmonary disease, which includes chronic bronchitis and emphysema, is a common somatic comorbidity of epilepsy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107175DOI Listing

Complex Regulatory Role of the TRPA1 Receptor in Acute and Chronic Airway Inflammation Mouse Models.

Int J Mol Sci 2020 Jun 9;21(11). Epub 2020 Jun 9.

Department of Pharmacology and Pharmacotherapy, Medical School and János Szentágothai Research Centre & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.

The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. Read More

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http://dx.doi.org/10.3390/ijms21114109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312832PMC

Farfarae Flos: A review of botany, traditional uses, phytochemistry, pharmacology, and toxicology.

J Ethnopharmacol 2020 Jun 8;260:113038. Epub 2020 Jun 8.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Farfarae Flos (FF; dried flower buds of Tussilago farfara L.), a widely used traditional Chinese medicine (TCM), is also known as "Kuandonghua" (Chinese: ). It has a wide range of pharmacological effects and has long been used to treat various respiratory conditions including cough, asthma, and acute or chronic bronchitis. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113038DOI Listing

Elevated chronic bronchitis diagnosis risk among women in a local emergency department patient population associated with the 2012 heatwave and drought in Douglas county, NE USA.

Authors:
Larry W Figgs

Heart Lung 2020 Jun 7. Epub 2020 Jun 7.

Douglas County Health Department, 1111 South 41 Street, Omaha, NE 68105 USA. Electronic address:

Background: Concerns about global climate change force local public health agencies to assess potential local disease risk.

Objective: Determine if risk of an emergency department chronic bronchitis diagnosis in Douglas County, NE, was higher during the 2012 heatwave compared to the same calendar period in 2011.

Methods: Retrospective, observational, case-control design selecting subjects from 2011 and 2012 emergency department (ED) admissions. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2020.03.022DOI Listing

Dioscorea nipponica Makino suppresses TPA-induced migration and invasion through inhibition of matrix metalloproteinase-9 in human cervical cancer cells.

Environ Toxicol 2020 Jun 10. Epub 2020 Jun 10.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Dioscorea nipponica Makino has been used for the treatment of chronic bronchitis, rheumatoid arthritis, cough, and asthma. Several studies have established the antitumor effect of D. nipponica Makino extract (DNE). Read More

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http://dx.doi.org/10.1002/tox.22984DOI Listing

Long interspersed nuclear element-1 methylation status in the circulating DNA from blood of patients with malignant and chronic inflammatory lung diseases.

Eur J Cancer Prev 2020 Jun 8. Epub 2020 Jun 8.

Cancer Research Institute, Tomsk National Research Medical Center, Tomsk.

Along with other malignant diseases, lung cancer arises from the precancerous lung tissue state. Aberrant DNA methylation (hypermethylation of certain genes and hypomethylation of retrotransposons) is known as one of the driving forces of malignant cell transformation. Epigenetic changes were shown to be detectable in DNA, circulating in the blood (cirDNA) of cancer patients, indicating the possibility to use them as cancer markers. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000601DOI Listing

Prevalence of Chronic Bronchitis and Respiratory Health Profile of a Population Exposed to Wood Smoke in Nicaragua.

J Health Pollut 2020 Jun 26;10(26):200607. Epub 2020 May 26.

University of Luebeck, Luebeck, Germany.

Background: Household air pollution (HAP) is one of the most important environmental risk factors worldwide associated with chronic respiratory diseases.

Objectives: The present study focused on respiratory health in a population with high wood smoke exposure in Nicaragua.

Methods: We employed a cross-sectional study with 213 participants. Read More

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http://dx.doi.org/10.5696/2156-9614-10.26.200607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269325PMC

Power Outage: An Ignored Risk Factor for Chronic Obstructive Pulmonary Disease Exacerbations.

Chest 2020 Jun 2. Epub 2020 Jun 2.

Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address:

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, with 16 million Americans currently suffering from difficult breathing. Power outages could be life-threatening for those relying on electricity. However, significant gaps remain in understanding the potential impact of power outages on COPD exacerbations. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.555DOI Listing

Bronchial Cartilage Assessment with Model-Based GAN Regressor.

Med Image Comput Comput Assist Interv 2019 Oct 10;11769:357-365. Epub 2019 Oct 10.

Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In the last two decades, several methods for airway segmentation from chest CT images have been proposed. The following natural step is the development of a tool to accurately assess the morphology of the bronchial system in all its aspects to help physicians better diagnosis and prognosis complex pulmonary diseases such as COPD, chronic bronchitis and bronchiectasis. Traditional methods for the assessment of airway morphology usually focus on lumen and wall thickness and are often limited due to resolution and artifacts of the CT image. Read More

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http://dx.doi.org/10.1007/978-3-030-32226-7_40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266165PMC
October 2019

Stenotrophomonas maltophilia Infection in a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD): A Colonizer or True Infection?

Am J Case Rep 2020 Jun 2;21:e924577. Epub 2020 Jun 2.

Department of Internal Medicine, Reading Hospital, Tower Health System, Reading, PA, USA.

BACKGROUND This article describes a finding of sputum culture positive for Stenotrophomonas maltophilia in an elderly woman with past medical history of chronic obstructive pulmonary disease (COPD) and hypertension, presenting with acute hypoxemic hypercapnic respiratory failure secondary to COPD exacerbation from bronchitis/bronchopneumonia. CASE REPORT Computed tomography (CT) of the chest showed secretions in the lower lobe bronchi and small scattered clustered nodules consistent with bronchitis/mild bronchopneumonia without evidence of pulmonary embolism. A sputum culture was positive for Stenotrophomonas maltophilia. Read More

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http://dx.doi.org/10.12659/AJCR.924577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295310PMC

Differences in diagnostic patterns of obstructive airway disease between areas and sex in Sweden and Finland - the Nordic EpiLung study.

J Asthma 2020 Jun 13:1-12. Epub 2020 Jun 13.

Department of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN unit, Umeå University, Umeå, Sweden.

To investigate the current prevalence of physician-diagnosed obstructive airway diseases by respiratory symptoms and by sex in Sweden and Finland. In 2016, a postal questionnaire was answered by 34,072 randomly selected adults in four study areas: Västra Götaland and Norrbotten in Sweden, and Seinäjoki-Vaasa and Helsinki in Finland. The prevalence of asthma symptoms was higher in Norrbotten (13. Read More

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http://dx.doi.org/10.1080/02770903.2020.1776727DOI Listing

The Ramapough Lunaape Nation: Facing Health Impacts Associated with Proximity to a Superfund Site.

J Community Health 2020 May 23. Epub 2020 May 23.

Department of Environmental Medicine, New York University Grossman School of Medicine, 341 East 25th Street, New York, NY, 10010, USA.

This study aimed to evaluate self-reported exposure to the Ringwood Mines/Landfill Superfund Site in relation to chronic health outcomes among members of the Ramapough Lunaape Turtle Clan nation and other local residents of Ringwood, New Jersey. Community surveys on personal exposure to the nearby Superfund site, self-reported health conditions, and demographics were conducted with 187 members of the Ramapough Lunaape Turtle Clan Nation and non-Native Americans residing in Ringwood, New Jersey from December 2015 to October 2016. Multiple logistic regression was performed to assess the association between ethnicity and a Superfund site exposure score developed for this study, as well as between exposure score and several chronic health conditions. Read More

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http://dx.doi.org/10.1007/s10900-020-00848-2DOI Listing

Epithelial Resurfacing: The Bronchial Skin Peel.

Am J Respir Crit Care Med 2020 May 22. Epub 2020 May 22.

Royal Brompton and Harefield NHS Foundation Trust, 4964, London, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1164/rccm.202004-1097EDDOI Listing

Chronic cough in adults.

Eur J Intern Med 2020 May 17. Epub 2020 May 17.

Azienda Ospedaliera Universitaria, Department of Medical Sciences, Section of Cardiorespiratory and Internal Medicine, University of Ferrara, Via Aldo Moro 8, 44124 Cona Ferrara, Italy.

Cough, a defense mechanism for clearing the airways of secretions, exudate, or foreign bodies, may become a troublesome symptom. Chronic cough, one of the most frequent symptoms requiring medical attention, is often not due to identifiable causes in adults. Chronic productive cough defines chronic bronchitis, and thus is present in 100% of these patients, and frequently in patients with bronchiectasis, cystic fibrosis, and chronic infectious respiratory diseases. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.03.018DOI Listing

Clinical analysis of 16 cases of pulmonary cryptococcosis in patients with normal immune function.

Ann Palliat Med 2020 May 15;9(3):1117-1124. Epub 2020 May 15.

Department of Pulmonary and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Background: Pulmonary cryptococcosis (PC) is an invasive pulmonary fungal disease caused by Cryptococcus neoformans or Cryptococcus gattii. Cryptococcus is the opportunistic pathogen. Immune damage and chronic consumptive diseases are the high risk. Read More

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http://dx.doi.org/10.21037/apm-20-897DOI Listing

Anesthesia During Functional Endoscopic Sinus Surgery for Kartagener's Syndrome: A Case Report and Literature Review.

Int J Gen Med 2020 1;13:157-161. Epub 2020 May 1.

Department of Anesthesiology and Intensive Care, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Introduction: Kartagener's syndrome (KS) is a ciliopathic, autosomal recessive disorder characterized by the triad of situs inversus, chronic sinusitis, and bronchiectasis. The abnormal ciliary structure and function lead to variable clinical manifestations, including dextrocardia, pneumonia, bronchitis, chronic rhinosinusitis, otitis media, reduced fertility in women, and infertility in men. This article reports our experience on general anesthesia with endotracheal intubation during functional endoscopic sinus surgery (FESS) in a patient with KS. Read More

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http://dx.doi.org/10.2147/IJGM.S251060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203035PMC

Aggregation of M3 (E376D) variant of alpha1- antitrypsin.

Sci Rep 2020 May 19;10(1):8290. Epub 2020 May 19.

UPR Signalling Laboratory, Department of Biotechnology, University of Kashmir, Srinagar, 190006, Jammu and Kashmir, India.

Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has an important role in neutralizing the neutrophil elastase activity. Different pathogenic point mutations like Z-α1AT have been implicated in the development of liver cirrhosis and Chronic Obstructive Pulmonary Disease (COPD), the latter being a cluster of progressive lung diseases including chronic bronchitis and emphysema. Read More

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http://dx.doi.org/10.1038/s41598-020-64860-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237413PMC

Age at death in elderly cohorts of four European countries of the Seven Countries Study: the role of comorbidities.

Aging Clin Exp Res 2020 May 14. Epub 2020 May 14.

Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.

Purpose: To study age at death (AD) in elderly men as a function of risk factors and morbid conditions in a 25-year follow-up.

Materials And Methods: Men enrolled in the Seven Countries Study belonging to 8 cohorts in 4 European countries (Finland, The Netherlands, Italy and Serbia) were examined between 1984 and 1989 (aged 65-84 years) with measurement of some cardiovascular risk factors and recording of a few major morbid conditions. AD was measured after 25-year follow-up and used in multiple linear regression (MLR) models as dependent variable; while, risk factors and morbid conditions had the role of independent variables. Read More

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http://dx.doi.org/10.1007/s40520-020-01568-2DOI Listing

Roflumilast in Severely Ill Patients with Chronic Obstructive Pulmonary Disease with Frequent Exacerbations: Risk of Pneumonia Hospitalization and Severe Exacerbations.

J Clin Med 2020 May 12;9(5). Epub 2020 May 12.

Department of Internal Medicine, Respiratory Medicine Section, Herlev and Gentofte Hospital, University Hospital of Copenhagen, 2900 Copenhagen, Denmark.

Roflumilast is given as an add-on to inhalation medication in patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Animal experiments have documented deleterious effects of roflumilast in bacterial infections, but trials have not reported the risk of bacterial infections in patients. The objective of this study is to determine, among outpatients with severe COPD in a two-year follow-up period, the risk of hospitalization-requiring pneumonia, severe acute exacerbation in COPD (AECOPD-hosp), and death. Read More

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http://dx.doi.org/10.3390/jcm9051442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291283PMC

Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 12 Month Results from a Multi-Center Study.

Am J Respir Crit Care Med 2020 May 14. Epub 2020 May 14.

Gala Therapeutics, Menlo Park, California, United States.

Rationale: Chronic bronchitis is characterized by productive cough with excessive mucus production, resulting in quality of life impairment and increased exacerbation risk. Bronchial Rheoplasty uses an endobronchial catheter to apply non-thermal pulsed electric fields to the airways. Preclinical studies demonstrated epithelial ablation followed by regeneration of normalized epithelium. Read More

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http://dx.doi.org/10.1164/rccm.201908-1546OCDOI Listing

Human Deoxyribonuclease (rhDNase) Nebulization as an Alternative Treatment for Refractory Plastic Bronchitis After Fontan Surgery.

Pediatr Cardiol 2020 Jun 14;41(5):1071-1073. Epub 2020 May 14.

Pediatric Pulmonology Unit, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals, Geneva, Switzerland.

We report the case of a 5-year-old boy who developed chronic plastic bronchitis after Fontan surgery for a complex congenital heart disease. During a new admission for acute exacerbation of plastic bronchitis, he started on a mucolytic treatment with inhaled rhDNAse instead of inhaled fibrinolytics because of the potential bleeding risk in a patient on combined coumarin and aspirin treatment. Respiratory symptoms resolved promptly, and the patient was discharged home on rhDNAse treatment. Read More

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http://dx.doi.org/10.1007/s00246-020-02368-1DOI Listing

Morbidity and mortality in carriers of the cystic fibrosis mutation Phe508del in the general population.

Eur Respir J 2020 May 12. Epub 2020 May 12.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Cystic fibrosis is caused by autosomal-recessive inheritance of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR), up to 90% due to Phe508del mutation in the gene. We tested the hypothesis that Phe508del carriers non-carriers in the general population have increased morbidity and mortality.We genotyped 108 035 randomly selected white Danish individuals aged 20-100 from the Copenhagen General Population Study for Phe508del (rs113993960). Read More

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http://dx.doi.org/10.1183/13993003.00558-2020DOI Listing

The Characteristics of Care Provided to Population(s) in Precarious Situations in 2015. A Preliminary Study on the Universal Health Cover in France.

Int J Environ Res Public Health 2020 May 9;17(9). Epub 2020 May 9.

Unité de Recherche Clinique Intersectionnelle en Psychiatrie à Vocation Régionale Pierre Deniker, Centre Hospitalier Henri Laborit, 86021 Poitiers, France.

: The French Universal Health Cover (CMU) aims to compensate for inequalities between precarious and non-precarious populations, enabling the former to access to free healthcare. These measures rely on the principle that precarious populations' health improves if healthcare is free. We designed a study to examine whether CMU fails to compensate for inequalities in reimbursed drugs prescriptions in precarious populations. Read More

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http://dx.doi.org/10.3390/ijerph17093305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246706PMC

[An epidemiological survey on clinical features, self-management and cognitive level of elderly asthmatics in China].

Zhonghua Yi Xue Za Zhi 2020 May;100(18):1426-1431

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

To investigate the prevalence of asthma among the elderly people in China and to analyze the clinical features, self-management and cognitive level of elderly asthma patients. According to the multi-stage random cluster sampling methods, a total of 164 215 subjects were visited by a questionnaire in the last epidemiology survey from eight provinces (Beijing, Shanghai, Guangdong, Liaoning, Henan, Shanxi, Jiangsu, Sichuan provinces) and seven regions (north, northeast, southern china, east, south, southwest and northwest) in China from February 2010 to August 2012. 2 034 were diagnosed as asthma. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191117-02498DOI Listing

Health and Economic Loss Assessment of PM Pollution during 2015-2017 in Gansu Province, China.

Int J Environ Res Public Health 2020 May 7;17(9). Epub 2020 May 7.

Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.

Many studies have reported that air pollution, especially fine particulate matter (PM), has a significant impact on health and causes economic loss. Gansu Province is in the northwest of China, which is a typical economically underdeveloped area. However, few studies have evaluated the economic loss of PM related to health effects in this province. Read More

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http://dx.doi.org/10.3390/ijerph17093253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246598PMC

Consumption of Vitamin K and Vitamin A Are Associated With Reduced Risk of Developing Emphysema: NHANES 2007-2016.

Front Nutr 2020 21;7:47. Epub 2020 Apr 21.

Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

Chronic obstructive pulmonary disease (COPD) comprising of emphysema and chronic bronchitis are the most common chronic respiratory diseases that impart a huge economic and clinical burden. Factors other than smoking and air pollutants can cause inflammation and emphysematous changes in the lung airspaces or alveoli have been understudied. Using a cross-sectional study design, we assessed the association of dark green vegetables, vitamin K and Vitamin A with emphysema status among adults at U. Read More

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http://dx.doi.org/10.3389/fnut.2020.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192023PMC

Chronic Vaping Related Tracheomalacia (TM): A Case of Vaping Induced Altered Innate Immunity that Culminated in Severe TM.

Cureus 2020 Apr 7;12(4):e7571. Epub 2020 Apr 7.

Internal Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, West Virginia University, Morgantown, USA.

Tracheomalacia (TM) is a weakness of the trachea either due to impaired cartilage integrity or atrophy of muscular elastic fibers. We present the first-ever case of chronic vaping induced altered immunological defenses that led to frequent pulmonary infections, ultimately culminating in severe TM which we successfully treated with positive airway pressure (PAP) therapy. A 53-year-old male presented with hypoxia and pneumonia refractory to outpatient antibiotics and steroids. Read More

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http://dx.doi.org/10.7759/cureus.7571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205362PMC

Incidence and Mortality of Lung Cancer Among Never Smokers in Relationship to Secondhand Smoking: Findings From the PLCO Trial.

Clin Lung Cancer 2020 Apr 13. Epub 2020 Apr 13.

Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada; Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:

Purpose: To assess the impact of secondhand smoking on the incidence and mortality of lung cancer among never smokers enrolled onto the Prostate, Lung, Colorectal, and Ovary (PLCO) study.

Patients And Methods: Deidentified data sets from the PLCO study were accessed and never smokers who completed the supplementary questionnaire's questions related to history of exposure to secondhand smoking were included in the current study. Multivariate Cox regression analysis was conducted to evaluate the impact of adulthood and childhood secondhand smoking on lung cancer incidence and mortality. Read More

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http://dx.doi.org/10.1016/j.cllc.2020.04.009DOI Listing
April 2020
3.104 Impact Factor

Emphysema - The review of radiological presentation and its clinical impact in the LDCT screening era.

Clin Imaging 2020 Aug 20;64:85-91. Epub 2020 Apr 20.

2nd Department of Radiology, Medical University of Gdansk, ul. Smoluchowskiego 17, 80-001 Gdansk, Poland.

Emphysema is one of three main lung pathologies in Chronic Obstructive Pulmonary Disease, along with chronic bronchitis and small airway obstruction. The diagnosis is based on detection of low attenuation areas in lung tissue on chest Computed Tomography, either visual by a radiologist, or automatic by the applied Computed Tomography software. Results of the studies on the association between emphysema and lung cancer incidence are mixed. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.04.018DOI Listing

Indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. protect against emphysema in mice.

J Ethnopharmacol 2020 Sep 5;259:112949. Epub 2020 May 5.

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China. Electronic address:

Ethnopharmacological Relevance: Alstonia scholaris (L.) R. Br. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112949DOI Listing
September 2020

FDA collaboration to improve safe use of fluoroquinolone antibiotics: an matched control study of targeted short-form messaging and online education served to high prescribers.

Pharm Pract (Granada) 2020 Apr-Jun;18(2):1773. Epub 2020 Apr 24.

MBA. Group Vice President. Marketing Sciences, WebMD. New York, NY (United States).

Objective: This matched control study was conducted to evaluate the effect of targeted short-form messages or continuing medical education (CME) on fluoroquinolone prescribing among high prescribers.

Methods: A total of 11,774 Medscape healthcare provider (HCP) members prescribing high volumes of fluoroquinolones were randomized into three segments to receive one of three unique targeted short-form messages, each delivered via email, web alerts, and mobile alerts. Some HCPs receiving targeted short-form messages also participated in CME on fluoroquinolone prescribing. Read More

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http://dx.doi.org/10.18549/PharmPract.2020.2.1773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194042PMC

Airway Remodeling in Ferrets with Cigarette Smoke Induced COPD using µCT Imaging.

Am J Physiol Lung Cell Mol Physiol 2020 May 6. Epub 2020 May 6.

Deparment of Medicine and the Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama, Birmingham, United States.

Rationale: Structural changes to airway morphology such as increased bronchial wall thickness (BWT) and airway wall area are cardinal features of chronic obstructive pulmonary disease (COPD). Ferrets are a recently established animal model uniquely exhibiting similar clinical and pathological characteristics of COPD as humans, including chronic bronchitis.

Objectives: Develop a µCT method for evaluating structural changes to the airways in ferrets, and assess whether the effects of smoking induce changes consistent with chronic bronchitis in humans. Read More

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http://dx.doi.org/10.1152/ajplung.00328.2019DOI Listing

Pharmacokinetics of Ambroxol Sustained Release (Mucosolvan Retard) Compared with Other Formulations in Healthy Volunteers.

Pulm Ther 2020 Jun 5;6(1):119-130. Epub 2020 May 5.

Department of Pharmacology, Johannes Gutenberg Universität, Mainz, Germany.

Introduction: Ambroxol is used in the treatment of acute and chronic respiratory conditions characterized by abnormal mucus secretion and impaired mucus transport and is available in a variety of formulations. This study aimed to compare the steady-state (SS) pharmacokinetic characteristics of extended-release (ER) 75-mg retard capsules with two immediate-release (IR) formulations (60-mg effervescent tablets and 30-mg tablets) over a 24-h period.

Methods: An open-label, randomized, three-period, six-sequence crossover study was conducted in healthy volunteers aged 18-45 years who had a normal body mass index. Read More

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http://dx.doi.org/10.1007/s41030-020-00116-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229136PMC