15,940 results match your criteria Chronic Bronchitis


Procalcitonin to guide antibiotic decision making.

Curr Opin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Department of Internal Medicine, Kantonsspital Aarau, Aarau.

Purpose Of Review: There is convincing evidence linking antibiotic-stewardship efforts which include the infection marker procalcitonin (PCT) to more rational use of antibiotics with improvements in side-effects and clinical outcomes. This is particularly true in the setting of respiratory infection and sepsis. Yet, some recent trials have shown no benefit of PCT-guided care. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000522DOI Listing
January 2019
6 Reads

Impact of Matrix Metalloproteinase 9 on COPD Development in Polish Patients: Genetic Polymorphism, Protein Level, and Their Relationship with Lung Function.

Biomed Res Int 2018 10;2018:6417415. Epub 2018 Dec 10.

Institute of Physiotherapy, Faculty of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland.

Chronic obstructive pulmonary disease (COPD) is characterized by a decline of lung function and symptoms such as chronic bronchitis and emphysema leading from lung tissue destruction. Increased activity of matrix metalloproteinases (MMPs) and an imbalance between MMPs and their tissue inhibitors (TIMPs) are considered as factors influencing the pathogenesis of COPD. We investigated the role of genetic polymorphism and expression level of MMP-9 and concentration of its complexes with TIMPs in the development of COPD among Polish patients. Read More

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http://dx.doi.org/10.1155/2018/6417415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311264PMC
December 2018
1 Read

Bronchoscopic device intervention in chronic obstructive pulmonary disease.

Curr Opin Pulm Med 2019 Jan 10. Epub 2019 Jan 10.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Purpose Of Review: Chronic obstructive pulmonary disease is a heterogeneous syndrome associated with varying degrees of parenchymal emphysema and airway inflammation resulting in decreased expiratory flow, lung hyperinflation, and symptoms leading to decreased exercise tolerance and quality of life. Impairment in lung function and quality of life persists following guideline-based medical therapy, thus surgical and minimally invasive bronchoscopic approaches were developed to address this unmet need. We offer a narrative review of the available technologies. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000561DOI Listing
January 2019

CPn0572, the C. pneumoniae ortholog of TarP, reorganizes the actin cytoskeleton via a newly identified F-actin binding domain and recruitment of vinculin.

PLoS One 2019 10;14(1):e0210403. Epub 2019 Jan 10.

Institute of Functional Microbial Genomics, Heinrich-Heine-University, Düsseldorf, Germany.

Chlamydia pneumoniae is one of the two major species of the Chlamydiaceae family that have a profound effect on human health. C. pneumoniae is linked to a number of severe acute and chronic diseases of the upper and lower respiratory tract including pneumonia, asthma, bronchitis and infection by the pathogen might play a role in lung cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210403PLOS
January 2019

[The two major complications of tobacco in a single image!]

Pan Afr Med J 2018 6;30:252. Epub 2018 Aug 6.

Service de Pneumologie de l'Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc.

Smoking is the leading cause of preventable death worldwide, it is responsible for 90% of bronchopulmonary cancers and is the main cause of chronic bronchitis and emphysema, two disorders which contribute to chronic obstructive pulmonary disease (COPD). We here report the case of a 58-year old not weaned chronic tabagic patient with a 2-month history of diffuse abdominal pain evolving in a context of alteration of the general state. Clinical examination showed generally poor health. Read More

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http://www.panafrican-med-journal.com/content/article/30/252
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http://dx.doi.org/10.11604/pamj.2018.30.252.16393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307924PMC
August 2018
1 Read

Epidemiology of chronic airway disease: results from a cross-sectional survey in Beijing, China.

J Thorac Dis 2018 Nov;10(11):6168-6175

Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Background: Although the epidemiology of chronic airway disease (CAD) has been investigated in several population-based studies, the findings of these studies are diverse. We aimed to investigate the prevalence of CAD and its associated factors in urban northern China.

Methods: A cross-sectional study was conducted among 29,359 Chinese adults aged ≥20 years. Read More

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http://dx.doi.org/10.21037/jtd.2018.10.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297443PMC
November 2018

Antiobesity Effect of Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice.

Evid Based Complement Alternat Med 2018 9;2018:1347612. Epub 2018 Dec 9.

Department of Food Science and Engineering, Jinzhou Medical University, Jinzhou 121001, China.

Franch. et Savat. (AC) has been used in traditional medicine for the treatment of chronic bronchitis, arthralgia, and gastralgia. Read More

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https://www.hindawi.com/journals/ecam/2018/1347612/
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http://dx.doi.org/10.1155/2018/1347612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304627PMC
December 2018
1 Read

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Background: Previous studies have identified lung, sputum or blood transcriptomic biomarkers associated with the severity of airflow limitation in COPD. Yet, it is not clear whether the lung pathobiology is mirrored by these surrogate tissues. The aim of this study was to explore this question. Read More

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http://dx.doi.org/10.1186/s12931-018-0965-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325784PMC
January 2019

MATERNAL STRESS AND ENVIRONMENTAL RISK FACTORS OF CHILDHOOD ASTHMA.

Georgian Med News 2018 Nov(284):98-102

David Tvildiani Medical University, Tbilisi; Batumi Shota Rustaveli State University, Georgia.

Asthma is a common disease with increasing prevalence both in children and adults. WHO estimates that annually 15 million disability-adjusted life-years are lost and 250,000 asthma deaths are reported worldwide. Approximately 500,000 annual hospitalizations are due to asthma. Read More

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November 2018

Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease.

J Med Food 2019 Jan 7. Epub 2019 Jan 7.

1 Department of Internal Medicine, College of Korean Medicine, Daejeon University , Daejeon, Korea.

Chronic obstructive pulmonary disease (COPD), including pulmonary emphysema and chronic bronchitis as well as structural and inflammatory changes in small airways, is insensitive to corticosteroid therapies. This study aimed to evaluate the effects of Scutellaria baicalensis root extract (SB_E) in a mouse model of COPD. The COPD mouse model was produced by challenging C57BL/6 mice with a cigarette smoke extract and lipopolysaccharide (LPS). Read More

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http://dx.doi.org/10.1089/jmf.2018.4200DOI Listing
January 2019

[Risk Factors of Asthma Attack in An Open Cohort].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Dec;40(6):797-802

Department of Community Nursing,Nursing School of Shandong University,Jinan 250012,China 2Cheeloo Research Center for Biomedical Big Data,Shandong University,Jinan 250012,China.

Objective To investigate the risk factors of asthma attack.Methods In this open cohort study,74 492 initially healthy subjects aged 20 years or more in a longitudinal multi-center health management cohort in Shandong province from January 2007 to December 2015 were enrolled in this study. These subjects had no baseline bronchial asthma or other chronic airway disease and did not migrate to other provinces in the past 10 years. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.10374DOI Listing
December 2018
1 Read

A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression.

Mol Ther 2018 Dec 6. Epub 2018 Dec 6.

Department of Immunology and Nanomedicine, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. Electronic address:

Transforming growth factor β (TGF-β), signaling induced by cigarette smoke (CS), plays an important role in the progression of airway diseases, like chronic bronchitis associated with chronic obstructive pulmonary disease (COPD), and in smokers. Chronic bronchitis is characterized by reduced mucociliary clearance (MCC). Cystic fibrosis transmembrane conductance regulator (CFTR) plays an important role in normal MCC. Read More

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http://dx.doi.org/10.1016/j.ymthe.2018.11.017DOI Listing
December 2018
1 Read

Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study.

Chest 2018 Dec 26. Epub 2018 Dec 26.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Background: Aspirin use in COPD has been associated with reduced all-cause mortality in meta-regression analysis with few equivocal studies. However, the effect of aspirin on COPD morbidity is unknown.

Methods: Self-reported daily aspirin use was obtained at baseline from SPIROMICS participants with COPD (FEV/FVC < 70%). Read More

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http://dx.doi.org/10.1016/j.chest.2018.11.028DOI Listing
December 2018

Prevalence and Risk Factors of ACO (Asthma-COPD Overlap) in Aboriginal People.

J Environ Public Health 2018 21;2018:4657420. Epub 2018 Nov 21.

Clinical Epidemiology Unit, Memorial University, Newfoundland and Labrador, Canada.

Background And Objective: Aboriginal peoples are at a higher risk of many chronic respiratory diseases compared to the general Canadian population. Patients with asthma-COPD overlap (ACO), a disease newly described in 2015, are associated with frequent exacerbations, rapid decline in lung function, poor quality of life, high mortality, and disproportionate utilization of health-care resources than patients with asthma and COPD alone. The objective was to investigate the prevalence and risk factors of ACO in Aboriginal peoples. Read More

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https://www.hindawi.com/journals/jeph/2018/4657420/
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http://dx.doi.org/10.1155/2018/4657420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280246PMC
November 2018
4 Reads

An approach to the child with a wet cough.

Authors:
F J Gilchrist

Paediatr Respir Rev 2018 Nov 23. Epub 2018 Nov 23.

Institute of Applied Clinical Science, Keele University, Keele ST5 5BG, UK; Academic Department of Child Health, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent ST4 6QG, UK. Electronic address:

When children have a wet cough, it suggests the presence of secretions in their airways. This often has an infectious aetiology which is usually a self-limiting viral infection requiring no investigation or treatment. In those with acute wet cough it is, however, important to identify features suggestive of community acquired pneumonia or an inhaled foreign body as these causes require specific management. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.11.002DOI Listing
November 2018
1 Read

Transgenerational effects of diesel particulate matter on Caenorhabditis elegans through maternal and multigenerational exposure.

Ecotoxicol Environ Saf 2019 Apr 19;170:635-643. Epub 2018 Dec 19.

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Chinese Academy of Sciences, Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China; Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, PR China. Electronic address:

Diesel particulate matter (DPM) is a dominant contaminant in fine particulate matters (PM) and has been proved to induce serious harmful effects to human beings, including lung cancer, allergic, and chronic bronchitis. However, little attention has been paid to understand the transgenerational effects of DPM. In the present study, we focused on the transgenerational effects of DPM in the model organism Caenorhabditis elegans (C. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.027DOI Listing
April 2019
1 Read

Vaporized E-Cigarette Liquids Induce Ion Transport Dysfunction in Airway Epithelia.

Am J Respir Cell Mol Biol 2018 Dec 21. Epub 2018 Dec 21.

University of Alabama at Birmingham, Department of Medicine, Gregory J. Fleming Cystic Fibrosis Center, Departments of Pediatrics and Cell Developmental and Integrative Biology, Birmingham, Alabama, United States ;

Cigarette smoking is associated with chronic obstructive pulmonary disease and chronic bronchitis. Acquired ion transport abnormalities, including CFTR dysfunction, caused by cigarette smoking have been proposed as potential mechanisms for mucus obstruction in chronic bronchitis. Although popular and perceived to be safe, it remains unclear if e-cigarette use harms the airways via mechanisms altering ion transport. Read More

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http://dx.doi.org/10.1165/rcmb.2017-0432OCDOI Listing
December 2018
2 Reads

A systematic review of phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets in China.

Medicine (Baltimore) 2018 Dec;97(51):e13689

Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Objective: In this study, we aimed to review the literature on phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets (CPEHTT).

Method: A literature search was performed in the following databases: WANFANG DATA, HowNet, National Library Reference and Consultation Alliance, Full-text Database of Foreign Medical Journals, PubMed and Ovid. The search terms were "Compound Phenytoin Sodium, ephedrine Hydrochloride and Theophylline Tablets," and "poisoning," or "toxicity," in Chinese and in English. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0007
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http://dx.doi.org/10.1097/MD.0000000000013689DOI Listing
December 2018
4 Reads

Non-pharmacological management of adult asthma in Australia: cross-sectional analysis of a population-based cohort study.

J Asthma 2018 Dec 20:1-8. Epub 2018 Dec 20.

a Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health , University of Melbourne , Melbourne , Victoria , Australia.

Aim: To identify the level of non-pharmacological care received by middle-aged adults with current asthma in Australia and to identify its association with clinical measures.

Methods: The Tasmanian Longitudinal Health Study (TAHS) is a population-based cohort first studied in 1968 (n = 8583). In 2010, when participants were aged 49 years, a stratified sample enriched for asthma and bronchitis underwent clinical assessments including respiratory questionnaires and lung function testing (n = 836). Read More

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http://dx.doi.org/10.1080/02770903.2018.1545030DOI Listing
December 2018
1 Read

Clinical features of patients with non-metastatic lung cancer in primary care: a case-control study.

BJGP Open 2018 Apr 7;2(1):bjgpopen18X101397. Epub 2018 Apr 7.

Professor, Department of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Lung cancer (LC) kills more people than any other cancer globally, mainly due to the late stage of diagnosis.

Aim: To identify and quantify the prediagnostic features of non-metastatic lung cancer (nMLC) and to compare the clinical features in GPs' chest X-ray referral letters with the clinical features (expressed as diagnostic codes) in medical records.

Design & Setting: A population-based case-control study was conducted using diagnostic codes from national and regional healthcare databases in Sweden. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181077PMC
April 2018
1 Read

Eosinophilic lung disease with plastic bronchitis and bronchiectasis in an adolescent male.

Clin Case Rep 2018 Dec 26;6(12):2407-2410. Epub 2018 Oct 26.

University of Illinois College of Medicine at Peoria Peoria Illinois.

Any case of unresolving chronic pneumonia with expectoration of thick mucoid plugs should have high index of suspicion for plastic/cast bronchitis, requiring early flexible bronchoscopy with lavage and histopathologic evaluation. Associated presence of idiopathic chronic eosinophilic pneumonia is unusual and could be considered as a cause for atypical plastic bronchitis complicated by bronchiectasis. Read More

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http://dx.doi.org/10.1002/ccr3.1853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293265PMC
December 2018
2 Reads

[Foreign body aspiration of the lower airways in children - diagnosis in clinical practice].

Orv Hetil 2018 Dec;159(51):2162-2166

Gyermekgyógyászati Klinika, Gyermeksebészeti Osztály, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.

Introduction And Aim: Rigid bronchoscopic foreign body removal is the gold standard procedure for foreign body aspiration. We have analysed our results of bronchoscopies and the accuracy of diagnosis among the paediatric population in Southeast Hungary.

Method: A retrospective study of children admitted because of suspected solid foreign body aspiration between 2006 and 2017 was performed. Read More

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https://www.akademiai.com/doi/10.1556/650.2018.31165
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http://dx.doi.org/10.1556/650.2018.31165DOI Listing
December 2018
4 Reads

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Lancet Respir Med 2019 Jan 11;7(1):20-34. Epub 2018 Dec 11.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:

Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.

Methods: In this genome-wide association study, we used a two-stage case-control design. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183038
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http://dx.doi.org/10.1016/S2213-2600(18)30389-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314966PMC
January 2019
5 Reads

Mechanisms of bergenin treatment on chronic bronchitis analyzed by liquid chromatography-tandem mass spectrometry based on metabolomics.

Biomed Pharmacother 2019 Jan 28;109:2270-2277. Epub 2018 Nov 28.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.11 North 3rd Ring East Road, Chao-Yang District, Beijing, 100029, China. Electronic address:

With increasing air pollution, chronic bronchitis (CB) has become a major public health problem worldwide. Previous studies have shown beneficial effects of Bergenin (Ber) on chronic bronchitis. To facilitate understanding of the pathogenesis underlying CB as well as to elucidate the Ber therapeutic mechanism, it is crucial to confirm the rational biomarkers of CB and its treatment. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.119DOI Listing
January 2019
10 Reads

Verdinexor (KPT-335), a selective inhibitor of nuclear export, reduces RSV replication .

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Animal Health Research Center, Department of Infectious Diseases, University of Georgia, Athens, GA 30602

Respiratory syncytial virus (RSV) is a leading cause of hospitalization of infants and young children causing considerable respiratory disease and repeat infections that may lead to chronic respiratory conditions such as asthma, wheezing, and bronchitis. RSV causes ∼34 million new episodes of lower respiratory tract illness (LTRI) in children younger than 5 years of age with >3 million hospitalizations due to severe RSV-associated LRTI. The standard of care is limited to symptomatic relief as there are no approved vaccines and few effective antiviral drugs, thus a safe and efficacious RSV therapeutic is needed. Read More

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http://dx.doi.org/10.1128/JVI.01684-18DOI Listing
December 2018

RISK EFFECTS OF NEAR-ROADWAY POLLUTANTS AND ASTHMA STATUS ON BRONCHITIC SYMPTOMS IN CHILDREN.

Environ Epidemiol 2018 Jun;2(2)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: Bronchitic symptoms in children pose a significant clinical and public health burden. Exposures to criteria air pollutants affect bronchitic symptoms, especially in children with asthma. Less is known about near-roadway exposures. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277033PMC
June 2018
1 Read

Effect of Comorbidity on Lung Cancer Diagnosis Timing and Mortality: A Nationwide Population-Based Cohort Study in Taiwan.

Biomed Res Int 2018 4;2018:1252897. Epub 2018 Nov 4.

School of Dentistry, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan.

The effect of comorbidity on lung cancer patients' survival has been widely reported. The aim of this study was to investigate the effects of comorbidity on the establishment of the diagnosis of lung cancer and survival in lung cancer patients in Taiwan by using a nationwide population-based study design. This study collected various comorbidity patients and analyzed data regarding the lung cancer diagnosis and survival during a 16-year follow-up period (1995-2010). Read More

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http://dx.doi.org/10.1155/2018/1252897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241217PMC
November 2018
3 Reads

Epidemiology of lower respiratory tract infections in adults.

Expert Rev Respir Med 2018 Dec 6. Epub 2018 Dec 6.

b Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa .

Introduction: Lower respiratory tract infections (LRTIs) are the leading infectious disease cause of death in the world and the fifth overall cause of death. From an epidemiological point of view, most consider pneumonia, influenza, bronchitis (including acute exacerbations in chronic obstructive pulmonary disease [AECOPD]), and bronchiolitis to be the most important LRTIs. Areas covered: This review will describe the epidemiology of LRTIs in adults focusing on community-acquired pneumonia, influenza, and AECOPD, utilizing data from the more recent literature. Read More

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https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
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http://dx.doi.org/10.1080/17476348.2019.1555040DOI Listing
December 2018
6 Reads

Protein-Losing Enteropathy and Plastic Bronchitis After the Fontan Operation.

Authors:
Christine Peyton

Crit Care Nurse 2018 Dec;38(6):e5-e12

Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.

Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More

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http://dx.doi.org/10.4037/ccn2018784DOI Listing
December 2018
1 Read

The role of environmental exposure to non-cigarette smoke in lung disease.

Clin Transl Med 2018 Dec 5;7(1):39. Epub 2018 Dec 5.

School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.

Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle-income countries. Children, women, the elderly and people with underlying chronic conditions are most affected. Read More

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http://dx.doi.org/10.1186/s40169-018-0217-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279673PMC
December 2018
1 Read

Stem cells therapy: a review on approaches that can be used for treatment of respiratory failures in sulfur mustard-injured patients.

Immunopharmacol Immunotoxicol 2018 Oct 29;40(5):359-367. Epub 2018 Nov 29.

c Chemical Injuries Research Center, Systems Biology and Poisonings Institute , Baqiyatallah University of Medical Sciences , Tehran , Iran.

Sulfur mustard (SM) is a toxic agent which causes severe abnormalities in an airway system such as necrosis and inflammation, oxidative stress, chronic bronchitis, shortness of breath, and chronic obstructive pulmonary disease. Although possible mechanisms of SM toxicity have been extensively considered, there is still need to find an appropriate clinical treatment to decrease chronic lung injuries caused by SM. Due to extensive progresses and achievement in tissue repairing through stem cells therapy, the importance of cell therapy for the treatment of lung injuries has been increased. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1510961DOI Listing
October 2018
7 Reads
1.109 Impact Factor

COPD, airflow limitation and chronic bronchitis in farmers: a systematic review and meta-analysis.

Occup Environ Med 2019 Jan 27;76(1):58-68. Epub 2018 Nov 27.

Service Hospitalier Universitaire Pneumologie Physiologie, Pôle Thorax et Vaisseaux, Grenoble, France.

Introduction: The current definition of chronic obstructive pulmonary disease (COPD) associates persistent airflow limitation and chronic respiratory symptoms. Agricultural work has been associated with an increased risk of developing COPD, but the prevalence and definition of the disease vary greatly between studies. This meta-analysis aimed to assess the association between agricultural work and COPD using the most widely used definitions of the disease. Read More

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http://dx.doi.org/10.1136/oemed-2018-105310DOI Listing
January 2019
1 Read

Anti-inflammatory effect of Juniperus procera extract in rats exposed to streptozotocin toxicity.

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 26. Epub 2018 Nov 26.

Medical Laboratory Department, University College - Turabah, Taif University. Saudi Arabia.

Background: Chronic inflammation is a critical health issue and implicated in several chronic health problems such as tumors, auto-immune disorder, hypertension or diabetes. However, Juniperus procera is one of the famous ancient plants that been traditionally used to treat several diseases such as hyperglycemia, hepatitis, jaundice, bronchitis, and pneumonia.

Objective: Current study is an attempt to investigate the anti-inflammatory effect of juniperus procera extract on rats exposed to cytotoxicity caused experimentally by streptozotocin injections. Read More

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http://dx.doi.org/10.2174/1871523018666181126124336DOI Listing
November 2018
11 Reads

Roflumilast in patients with advanced chronic obstructive pulmonary disease: towards a better-targeted use.

Expert Opin Pharmacother 2018 Nov 21:1-3. Epub 2018 Nov 21.

f Department of Surgery-Thoracic Surgery , Grigore T Popa University of Medicine and Pharmacy , Iasi , Romania.

Introduction: For patients with chronic obstructive pulmonary disease (COPD), one of the main goals in its management is to reduce the number of disease exacerbations. Roflumilast is an anti-inflammatory compound used in patients with advanced COPD and chronic bronchitis in order to fulfill this objective. However, this is not always easily achieved due to the heterogeneity of the population. Read More

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http://dx.doi.org/10.1080/14656566.2018.1544244DOI Listing
November 2018
13 Reads

Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults.

Clin Infect Dis 2018 Nov 19. Epub 2018 Nov 19.

Novavax, Gaithersburg, MD. USA.

Background: Respiratory syncytial virus (RSV) is an important but under-recognized cause of serious respiratory illness in adults. Recent comparative data on RSV and influenza infection in hospitalized adults may increase awareness of RSV disease burden in adults.

Methods: Hospitalized adults ≥60 years old testing positive for RSV or influenza by multiplex RT-PCR or viral culture between 01/01/2011 and 06/30/2015 were identified from Kaiser Permanente Southern California electronic medical records. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy991DOI Listing
November 2018
8 Reads

Improved quality of life associated with long-term use of guaifenesin in a patient with chronic obstructive pulmonary disease (COPD) & stable chronic bronchitis: A case report.

Respir Med Case Rep 2019 3;26:9-10. Epub 2018 Nov 3.

SRxA Strategic Pharmaceutical Advisors, 1750 Tysons Boulevard, Suite 1500, McLean, VA 22102, USA.

We read with interest the recent case reports in this journal on the apparent beneficial effects of long-term, high-dose guaifenesin in patients with chronic respiratory disease. This prompted us to review our own patient database as we also recommend daily guaifenesin to patients who report problems with mucociliary clearance. In our rural primary care practice, we currently have over 20 patients who have taken guaifenesin daily, for more than 3 years as an adjuvant to their prescribed medications for either chronic obstructive pulmonary disease (COPD) and/or stable chronic bronchitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183031
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http://dx.doi.org/10.1016/j.rmcr.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226562PMC
November 2018
9 Reads

Association of low income with pulmonary disease progression in smokers with and without chronic obstructive pulmonary disease.

ERJ Open Res 2018 Oct 12;4(4). Epub 2018 Nov 12.

Dept of Medicine, National Jewish Health, Denver, CO, USA.

Low socioeconomic status has been associated with chronic obstructive pulmonary disease (COPD) but little is known about its impact on disease progression. We assessed the association of income to symptoms, pulmonary disease severity and progression in smokers with and without COPD. The COPDGene cohort of 4826 smokers who reported annual income in phase 2 was analysed. Read More

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http://openres.ersjournals.com/lookup/doi/10.1183/23120541.0
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http://dx.doi.org/10.1183/23120541.00069-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230816PMC
October 2018
5 Reads

Study of the metabolomic relationship between lung cancer and chronic obstructive pulmonary disease based on direct infusion mass spectrometry.

Biochimie 2018 Nov 13;157:111-122. Epub 2018 Nov 13.

Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Research Center on Health and Environment (RENSMA), 21007, Huelva, Spain. Electronic address:

The high prevalence of lung cancer (LC) has triggered the search of biomarkers for early diagnosis of this disease. For this purpose the study of metabolic changes related to the development of lung cancer could provide interesting information about its early diagnosis. In this sense, chronic obstructive pulmonary disease (COPD), a disease associated with tumor development, is a comorbidity that increases the risk of onset and progression of lung neoplasia and has also to be considered in the study of pathology related to lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009084183032
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http://dx.doi.org/10.1016/j.biochi.2018.11.007DOI Listing
November 2018
10 Reads

[A case report of an adult with bronchial mould infection complicated by purulent pleurisy].

Authors:
Fbr Mbaye

Rev Mal Respir 2018 Nov 11. Epub 2018 Nov 11.

Université Cheikh Anta Diop, faculté de médecine service de pneumologie de Fann, Dakar, Sénégal. Electronic address:

Introduction: Bronchial mould infection or plastic bronchitis is a rare condition, encountered at any age, but with a predilection for childhood. The clinical diagnosis is made easy by the demonstration of solid, branched expectorations. However, the aetiology is not easy to determine and investigation does not often lead to a pathological diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07618425183032
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http://dx.doi.org/10.1016/j.rmr.2018.02.013DOI Listing
November 2018
5 Reads

A case report of brain abscess caused by in a diabetic patient.

JMM Case Rep 2018 Sep 10;5(9):e005133. Epub 2018 Jan 10.

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: are Gram-positive partially acid-fast bacilli capable of inducing a wide range of infections in patients with immunodeficiency, AIDS, cancer, lupus erythematous and diabetes. was first isolated in 2001 from a patient with chronic bronchitis. Since then, there have been reports on the clinical significance of this organism in patients with bronchitis, brain abscess and lung diseases. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230754PMC
September 2018
3 Reads

Spectrum-effect relationships between high-performance liquid chromatography fingerprints and anti-inflammatory activities of Leontopodium leontopodioides (Willd.) Beauv.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 6;1104:11-17. Epub 2018 Nov 6.

Liaoning University of Traditional Chinese Medicine, Dalian 116600, PR China. Electronic address:

Leontopodium leontopodioides (Willd.) Beauv. is used therapeutically to prevent numerous diseases. Read More

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http://dx.doi.org/10.1016/j.jchromb.2018.11.001DOI Listing
January 2019
3 Reads
2.730 Impact Factor

[Being diagnosed with COPD: A qualitative study of real life experience].

Rev Mal Respir 2018 Nov 8. Epub 2018 Nov 8.

Département d'enseignement et de recherche en médecine générale, faculté de médecine, université Nice-Sophia-Antipolis, 06107 Nice, France.

Introduction: This qualitative study aimed to explore the real life experience of the patients with chronic obstructive pulmonary disease (COPD) at the time they receive the diagnosis.

Methods: Data were collected using face to face interviews in general practice as well as focus groups in a pulmonary rehabilitation centre.

Results: Thirty-four patients participated in the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07618425183033
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http://dx.doi.org/10.1016/j.rmr.2018.10.007DOI Listing
November 2018
4 Reads

Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs.

Clin Exp Allergy 2018 Nov 11. Epub 2018 Nov 11.

State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: The pathogenesis and pathophysiology of eosinophilia-related chronic cough such as non-asthmatic eosinophilic bronchitis and cough variant asthma are still not clear.

Objective: This study is to examine the potential role of traffic-related air pollution (TRAP) in eosinophilic inflammation and cough responses.

Methods: Non-sensitized guinea-pigs were exposed to TRAP in an urban traffic tunnel or kept in a filtered air environment for 7 or 14 days. Read More

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http://doi.wiley.com/10.1111/cea.13308
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http://dx.doi.org/10.1111/cea.13308DOI Listing
November 2018
17 Reads
4.770 Impact Factor

Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults.

Multidiscip Respir Med 2018 2;13:40. Epub 2018 Nov 2.

2Preventive Medicine Department, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.

Fifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (, , and ). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of the I gene among isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed. Based on published data, an overall analysis is performed for PK/PD susceptibility interpretation. Read More

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https://mrmjournal.biomedcentral.com/articles/10.1186/s40248
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http://dx.doi.org/10.1186/s40248-018-0152-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214181PMC
November 2018
17 Reads

Variation in Outpatient Antibiotic Dispensing for Respiratory Infections in Children by Clinician Specialty and Treatment Setting.

Pediatr Infect Dis J 2018 Dec;37(12):1248-1254

Medical and Clinical Pharmacy Policy, Anthem, Inc, Chicago, Illinois.

Background: Antibiotics are commonly prescribed for children with acute respiratory infections (ARIs). This study describes the distribution of ARI diagnoses and specifically quantifies antibiotic dispensing for bronchitis and upper respiratory infection (URI) by treatment setting and specialty.

Methods: This retrospective, observational cross-sectional study used data from the HealthCore Integrated Research Environment containing claims from 14 commercial health plans for 2012 to 2014. Read More

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http://dx.doi.org/10.1097/INF.0000000000002004DOI Listing
December 2018
6 Reads

Prevalence and risk factors of chronic obstructive pulmonary disease in dairy farmers: AIRBAg study.

Environ Res 2018 Oct 27;169:1-6. Epub 2018 Oct 27.

Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France; Department of Epidemiology and Public Health, University Hospital, F-35033 Rennes, France. Electronic address:

Background: The AIRBAg study was designed to assess the prevalence of chronic obstructive pulmonary disease (COPD) in dairy farmers and to define its associated risk factors.

Methods: Between March 2012 and February 2017 randomly selected dairy farmers in the French region of Brittany were asked to complete a self-administered questionnaire and undergo an occupational health check-up with electronic mini-spirometry and standard spirometry. Those having one or more of the following features: chronic cough, chronic bronchitis, wheezing, dyspnea and/or a ratio FEV/FEV < 80% were then referred to a pulmonologist for further check-up including spirometry with a reversibility test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351183056
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http://dx.doi.org/10.1016/j.envres.2018.10.026DOI Listing
October 2018
8 Reads

N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluation.

Daru 2018 Dec 3;26(2):199-207. Epub 2018 Nov 3.

Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Background: Fluoroquinolones (FQs) are compounds of major interest with broad antimicrobial activities against community and hospital-acquired infections such as respiratory tract infections (nosocomial pneumonia, chronic bronchitis and tuberculosis), skin and soft tissue infections, bone and joint infections, intra-abdominal infections and sexually transmitted diseases. This broad range of activities along with favorable pharmacokinetic and low toxicity introduced this class of compounds as important antimicrobial chemotherapy agents. The rapid increase in prevalence of FQs resistant microbes in environment motivated medicinal chemists to discover new quinolone-based compounds with potent activities against Gram-positive bacteria. Read More

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https://darujps.biomedcentral.com/articles/10.1007/s40199-01
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http://dx.doi.org/10.1007/s40199-018-0226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279671PMC
December 2018
7 Reads

Typing of chronic obstructive pulmonary disease using high-resolution computed tomography and the association with smoking, airway inflammation, and common comorbidities

Turk J Med Sci 2018 Oct 31;48(5):945-951. Epub 2018 Oct 31.

Background/aim: This study performed typing of chronic obstructive pulmonary disease (COPD) using high-resolution computed tomography (HRCT) to determine the association with smoking, matrix metalloproteinases, and common comorbidities. Materials and methods: The study enrolled 94 hospitalized patients. Participants were divided into a group of 69 current and former smokers (group A) and a group of 25 that had never smoked (group B). Read More

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http://dx.doi.org/10.3906/sag-1712-39DOI Listing
October 2018
18 Reads