7,150 results match your criteria Chronic Bacterial Prostatitis


A longitudinal analysis of urologic chronic pelvic pain syndrome flares in the mapp research network.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Objective: To describe the frequency, intensity, and duration of urologic chronic pelvic pain syndrome symptom exacerbations ("flares"), as well as risk factors for these features, in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Epidemiology and Phenotyping longitudinal study.

Participants And Methods: Current flare status ("urologic or pelvic pain symptoms that are much worse than usual") was ascertained at each bi-weekly assessment. Flare characteristics, including start date, and current intensity of pelvic pain, urgency, and frequency (scales of 0-10), were assessed for participants' first three flares and at three randomly selected times when they did not report a flare. Read More

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http://dx.doi.org/10.1111/bju.14783DOI Listing

The effectiveness of the combination of rectal electrostimulation and an antidepressant in the treatment of chronic abacterial prostatitis.

Cent European J Urol 2019 10;72(1):66-70. Epub 2019 Jan 10.

State Institution "Institute of Urology of National Academy of Medical Sciences of Ukraine", Kiev, Ukraine.

Introduction: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex medical problem. Comorbid depression and chronic pain are highly prevalent in individuals suffering with chronic abacterial prostatitis (CAP) perhaps due to the direct or indirect effects of cytokines. Cytokines interact with the neuronal environment, and thus modulation of the duration of inflammation may alleviate depressive and pain symptoms. Read More

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http://dx.doi.org/10.5173/ceju.2018.1719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469008PMC
January 2019

Surgical and functional outcomes of radical retropubic prostatectomy after biopsy-related acute prostatitis.

Cent European J Urol 2019 22;72(1):19-22. Epub 2019 Jan 22.

TC Saglik Bakanligi Haydarpasa Numune Egitim ve Arastirma Hastanesi, Department of Urology, Istanbul, Turkey.

Introduction: The present study sought to evaluate the intraoperative, postoperative, oncologic, and functional results of radical prostatectomy (RP) after previous prostatitis.

Material And Methods: We retrospectively reviewed available data of 320 patients undergoing open radical prostatectomy between 2010 and 2016. From this group, 23 (7. Read More

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http://dx.doi.org/10.5173/ceju.2018.1825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469011PMC
January 2019

A 'pathogenic needle' in a 'commensal haystack': Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system.

Med Hypotheses 2019 May 22;126:38-41. Epub 2019 Mar 22.

University Centre Varaždin, University North, Varaždin, Croatia.

The predominance of the genus Corynebacterium in the healthy male urogenital system contributes to the resident microbiome of not only the distal urethra, but potentially the proximal urethra and urinary bladder as well. However, for certain species in this genus, pathogenic potential was described, and the salient representative is Corynebacterium glucuronolyticum (C. glucuronolyticum) implicated in cases of urethritis and prostatitis in men. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.011DOI Listing
May 2019
1 Read

[FOUR CASES OF THE PROSTATIC ABSCESS IN WHICH DRAINAGE WAS EFFECTIVE].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(2):122-126

Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama.

We encountered four prostatic abscess patients. Although antimicrobial therapies were ineffective, drainage was effective in all cases. Patient 1 had lung cancer and diabetes mellitus (DM), and patient 2 developed acute prostatitis after transrectal prostatic biopsy. Read More

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https://www.jstage.jst.go.jp/article/jpnjurol/109/2/109_122/
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http://dx.doi.org/10.5980/jpnjurol.109.122DOI Listing
January 2018
1 Read

Danish version of the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) questionnaire: a linguistic translation, cross-cultural adaptation and test-re-test reliability study.

Scand J Urol 2019 Apr 21:1-7. Epub 2019 Apr 21.

a Department of Sports Science and Clinical Biomechanics , University of Southern Denmark , Odense , Denmark.

Objective: To translate and cross-culturally adapt the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) into Danish and assess the reliability of the translated version.

Methods: The NIH-CPSI was translated into Danish by a formalized translation procedure. Study participants suffering from Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) were recruited from a CP/CPPS newsletter email-list. Read More

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http://dx.doi.org/10.1080/21681805.2019.1591501DOI Listing
April 2019
1 Read

Which clinical and radiological characteristics can predict clinically significant prostate cancer in PI-RADS 3 lesions? A retrospective study in a high-volume academic center.

Eur J Radiol 2019 May 25;114:92-98. Epub 2019 Feb 25.

Department of Radiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Electronic address:

Objective: To investigate which clinical and radiological characteristics can predict clinically significant prostate cancer (csPCa) in PI-RADS 3 lesions. To investigate which clinical and radiological characteristics influence the clinician to biopsy a PI-RADS 3 lesion.

Materials And Methods: mpMRI PI-RADS 3 lesions scored by 1 out of 3 highly specialized radiologists in a single high-volume center during the period March 2015 to August 2017 were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193008
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http://dx.doi.org/10.1016/j.ejrad.2019.02.031DOI Listing
May 2019
1 Read

Extracorporeal Shockwave Therapy Combined with Drug Therapy in Chronic Pelvic Pain Syndrome - A Randomized Clinical Trial.

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) is a nonspecific pelvic pain in the absence of signs of infection or other obvious local pathology for at least 3 of the last 6 months. The evidence for treatment is limited so the aim of this study is to investigate the effect of extracorporeal shock wave therapy (ESWT) combined with pharmacotherapy in the treatment of CP/CPPS.

Materials And Methods: In this randomized clinical  trial, 31 patients with CP/CPPS were investigated in two groups: the intervention group (n=16) was treated with a combination of an alfa-blocker, an anti-inflammatory agent, a muscle relaxant and a short course of antibiotic in combination with 4 sessions of focused ESWT (a protocol of 3000 impulses, 0. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4673DOI Listing
April 2019
1 Read

Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3112-3120

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Objective: Male infertility is a wide spread disease among couple of childbearing age. Spermatozoa are highly susceptible to oxidative stress. Reactive oxygen species (ROS) are capable of damaging the sperm membrane and DNA, inducing lipid peroxidation and sperm DNA fragmentation (SDF). Read More

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http://dx.doi.org/10.26355/eurrev_201904_17595DOI Listing

IgG4-related Periarteritis Successfully Diagnosed by an Alternative Prostate Biopsy: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Japan.

A 56-year-old man was referred to our facility after developing edema in his right leg. Enhanced computed tomography (CT) revealed a periarterial soft tissue mass surrounding the right iliac artery compressing the iliac vein. His elevated serum IgG4 level indicated IgG4-related disease (IgG4-RD). Read More

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http://dx.doi.org/10.2169/internalmedicine.2723-19DOI Listing

Genetic and Environmental Influences on Urinary Conditions in Men: A Classical Twin Study.

Urology 2019 Apr 12. Epub 2019 Apr 12.

University of California, San Diego, San Diego, CA, USA; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA. Electronic address:

Objective: To evaluate the genetic and environmental relationship among prostatitis and other urological conditions, including benign prostatic hyperplasia (BPH) and prostate cancer (CaP), a classical twin design and biometric modeling was used. While prostatitis - characterized by pain and voiding symptoms, no clear etiology, and functional and quality of life impairments - co-occurs with other urinary conditions, the degree of shared overlapping etiological processes among them remains unclear. We examined the contribution of genetic and environmental factors to these conditions and the etiology of their associations at the level of genetic and environmental influences. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193034
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http://dx.doi.org/10.1016/j.urology.2019.04.005DOI Listing
April 2019
1 Read

Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring.

Food Chem Toxicol 2019 Apr 12;128:193-201. Epub 2019 Apr 12.

Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Catalonia, Spain. Electronic address:

This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.013DOI Listing

Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping.

Invest Radiol 2019 Apr 12. Epub 2019 Apr 12.

Case Western University School of Medicine, Departments of.

Objective: This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers.

Materials And Methods: One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectively analyzed with apparent diffusion coefficient (ADC) mapping, MRF, and targeted biopsy (cognitive or in-gantry). A radiologist blinded to pathology drew regions of interest on targeted lesions and visually normal peripheral zone on MRF and ADC maps. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000569DOI Listing
April 2019
4.437 Impact Factor

False-Positive 68Ga-DOTATATE PET/CT in Active Chronic Prostatitis.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Urology Department, Kanuni Sultan Suleyman Research and Training Hospital, Health Sciences University, Istanbul, Turkey.

A 66-year-old man with neuroendocrine tumor originating from midgut was referred to Ga-DOTATATE PET/CT imaging for restaging postoperatively. No suspicious uptake regarding residual primary tumoral involvement was seen. But there was diffuse high uptake in prostate gland suggestive of prostatitis or secondary primary tumoral lesion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002594DOI Listing
April 2019
2 Reads

Clinical approach to prostatic diseases in the dog.

Reprod Domest Anim 2019 Apr 11. Epub 2019 Apr 11.

Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Ozzano dell'Emilia (Bo), Italy.

In small animal practice, prostatic diseases are increasingly encountered. All dogs may experience prostatic disease, but particular care should be addressed to breeding dogs, in which prostatic affection may lead to decrease in semen quality and fertility. The most common prostatic disease is the benign prostatic hyperplasia (BPH) followed by prostatitis, prostatic neoplasia and prostate squamous metaplasia. Read More

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http://dx.doi.org/10.1111/rda.13437DOI Listing

International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats.

Vet J 2019 May 26;247:8-25. Epub 2019 Feb 26.

School of Veterinary Medicine, Department of Medicine & Epidemiology, 2108 Tupper Hall, University of California-Davis, Davis, CA 95616, USA.

Urinary tract disease is a common clinical presentation in dogs and cats, and a common reason for antimicrobial prescription. This document is a revision and expansion on the 2011 Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cats, providing recommendations for diagnosis and management of sporadic bacterial cystitis, recurrent bacterial cystitis, pyelonephritis, bacterial prostatitis, and subclinical bacteriuria. Issues pertaining to urinary catheters, medical dissolution of uroliths and prophylaxis for urological procedures are also addressed. Read More

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http://dx.doi.org/10.1016/j.tvjl.2019.02.008DOI Listing
May 2019
1 Read

Multiparametric MRI appearances of primary granulomatous prostatitis.

Br J Radiol 2019 Apr 9:20180075. Epub 2019 Apr 9.

4 Department of Radiology, Southend University Hospital, Westcliff-on-Sea , Essex , UK.

Objective: Radiological features of granulomatous prostatitis (GP) overlap with those of prostate adenocarcinoma. Identification of specific GP features may aid diagnosis. We aimed to evaluate the multiparametric MRI (mpMRI) features of GP. Read More

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http://dx.doi.org/10.1259/bjr.20180075DOI Listing

Impact of Metabolically Healthy Obesity in Patients with Andrological Problems.

J Sex Med 2019 Apr 5. Epub 2019 Apr 5.

Endocrinology Unit, Medical Department, Azienda USL, Maggiore-Bellaria Hospital, Bologna, Italy. Electronic address:

Background: Although the pathogenic role of metabolically complicated obesity (MCO) in erectile dysfunction (ED), major adverse cardiovascular events (MACE), and male infertility has been widely studied, that of metabolically healthy obesity (MHO) has been poorly investigated.

Aim: To assess the role of MHO in the pathogenesis of ED, prediction of MACE, and male reproductive health.

Methods: A consecutive series of 4,945 men (mean age, 50. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.03.006DOI Listing
April 2019
2 Reads

Selective culture of Escherichia coli to prevent infective complications of transrectal ultrasound-guided prostate biopsy: Clinical efficacy and analysis of characteristics of quinolone-resistant Escherichia coli.

Int J Urol 2019 Apr 8. Epub 2019 Apr 8.

Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.

Objectives: To evaluate a regimen of targeted prophylaxis using rectal swab culture in patients undergoing transrectal ultrasound-guided prostate biopsy, and to investigate the characteristics of isolated fluoroquinolone-resistant Escherichia coli.

Methods: A prospective study was carried out from June 2013 through December 2014. Rectal swabs were cultured on agar plates containing either 2 μg/mL levofloxacin or 1 μg/mL sitafloxacin before transrectal ultrasound-guided prostate biopsy. Read More

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http://dx.doi.org/10.1111/iju.13960DOI Listing
April 2019
1 Read

Risk factors for febrile genito-urinary infection in the catheterized patients by with spinal cord injury-associated chronic neurogenic lower urinary tract dysfunction evaluated by urodynamic study and cystography: a retrospective study.

World J Urol 2019 Apr 4. Epub 2019 Apr 4.

Division of Urology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan.

Introduction: To investigate the risk factors for febrile genito-urinary tract infection (GUTI) in spinal cord injury-associated neurogenic lower urinary tract dysfunction (NLUTD) patients who perform routine clean intermittent catheterization (CIC) evaluated by urodynamic study (UDS) and cystography.

Patients And Methods: Over a 3-year period, we retrospectively assessed risk factors for febrile UTI in 141 spinal cord injury patients diagnosed as NLUTD and performing routine CIC, regarding gender, UDS findings such as bladder compliance, maximum cystometric capacity, and cystography.

Results: A total of 41 patients had febrile GUTI in the follow-up period as along with 32 cases of pyelonephritis, 10 cases of epididymitis, and 1 case of prostatitis, including patients with multiple infectious diseases. Read More

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http://dx.doi.org/10.1007/s00345-019-02743-5DOI Listing
April 2019
2 Reads

Qian lie an suppository (prostant) for chronic prostatitis: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2019 Apr;98(14):e15072

Office of Science and Technology Administration, Beijing University of Chinese Medicine, Beijing, China.

Background: Chronic prostatitis (CP) is an inflammation of the prostate gland that seriously affects the quality of life of patients. The existing evidence of antibiotics and α-blockers for the treatment of CP is limited.

Objectives: This review evaluated the effectiveness and safety of Qian Lie An Suppository (Prostant) in treating CP. Read More

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http://dx.doi.org/10.1097/MD.0000000000015072DOI Listing

For Physicians Managing Voiding Dysfunction, Improving the Detection Rate of Early Prostate Cancer and Discrimination From Benign Prostatic Hyperplasia, in a Molecular Biomarker Aspects.

Int Neurourol J 2019 Mar 31;23(1):5-12. Epub 2019 Mar 31.

Department of Urology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

Prostate cancer (CaP) is the most common cancer diagnosed among men in the United States and the fifth most common cancer among men in Korea. Unfortunately, the early stages of CaP may have no symptoms. Thus, early detection is very important and physicians managing voiding dysfunction must have awareness about CaP. Read More

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http://dx.doi.org/10.5213/inj.1836262.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449661PMC
March 2019
4 Reads

The Role of GM-CSF in a Mouse Model of Experimental Autoimmune prostatitis.

Am J Physiol Renal Physiol 2019 Apr 3. Epub 2019 Apr 3.

Urology, Qilu Hospital of Shandong University, China.

The etiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still unknown. Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to play an important role in the development of autoimmune and inflammatory diseases. Here, we investigated the expression and function of GM-CSF in CP/CPPS patients and in a mouse model of Experimental Autoimmune prostatitis (EAP). Read More

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http://dx.doi.org/10.1152/ajprenal.00013.2018DOI Listing
April 2019
2 Reads

Successful treatment with pollen extract of hematospermia in patients with xanthogranolomatous prostatitis.

Arch Ital Urol Androl 2019 Mar 29;91(1):22-24. Epub 2019 Mar 29.

Sapienza University of Rome, Faculty of Pharmacy and Medicine, Department of Medico-Surgical Sciences and Biotechnologies, Urology Unit, Latina; Uroresearch, no profit Association for Research in Urology, Latina.

Introduction: The aim of this study was to report our experience in the management of hematospermia observed in 16 patients suffering from xanthogranulomatous prostatitis.

Methods: Recurrent episodes of hematospermia were the onset symptom in all patients, and in 25% of patients it was combined with fever. All patients reported PSA value elevation and the digital rectal examination (DRE) revealed an increase of the gland size and of its consistency in all cases. Read More

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https://www.pagepressjournals.org/index.php/aiua/article/vie
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http://dx.doi.org/10.4081/aiua.2019.1.22DOI Listing
March 2019
6 Reads

The role of anticholinergic therapy based on the upoint system in the treatment of chronic prostatitis.

Arch Ital Urol Androl 2019 Mar 29;91(1):16-21. Epub 2019 Mar 29.

Acibadem Mehmet Ali Aydinlar University, Urology, Istanbul.

Objective: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common problem and severely impairs the quality of life (QoL). We aimed to investigate the effects of different treatment options on voiding symptoms and QoL in patients with urinary phenotype according to the UPOINT system. Matherial and methods: Ninety-six patients with NIH category II,III CP/CPPS were included in the study prospectively. Read More

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https://www.pagepressjournals.org/index.php/aiua/article/vie
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http://dx.doi.org/10.4081/aiua.2019.1.16DOI Listing
March 2019
9 Reads

Analysis of PI-RADS 4 cases: Management recommendations for negatively biopsied patients.

Eur J Radiol 2019 Apr 1;113:1-6. Epub 2019 Feb 1.

Department of Diagnostic and Interventional Radiology, Univ Dusseldorf, Medical Faculty, Moorenstr. 5, D-40225 Dusseldorf, Germany. Electronic address:

Purpose: To evaluate if subgroups of patients assigned to MRI category PI-RADS 4 regarding clinical and MRI imaging aspects have distinct risks of prostate cancer (PCa) to facilitate adequate clinical management of this population, especially after negative targeted biopsy.

Methods: This prospective, IRB approved single center cross-sectional study includes 931 consecutive patients after mp-MRI at 3 T for PCa detection. 193 patients with PI-RADS assessment category 4 received subsequent combined targeted MRI/US fusion-guided and systematic 12-core TRUS-guided biopsy as reference standard and were finally analyzed. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.030DOI Listing

Chronic prostatitis/chronic pelvic pain syndrome increases susceptibility to seizures in rats and alters brain levels of IL-1β and IL-6.

Epilepsy Res 2019 Mar 22;153:19-27. Epub 2019 Mar 22.

Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia. Electronic address:

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a result of interplay between psychological, immune, neurological and genetic factors, manifested by variety of urological, as well as brain-related symptoms. However, its relation with brain excitability has not been addressed. herefore, our aim was to assess susceptibility to seizures in rats with CP/CPPS. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.014DOI Listing
March 2019
5 Reads

Clustering of Patients with Interstitial Cystitis/Bladder Pain Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

J Urol 2019 Mar 27:101097JU0000000000000250. Epub 2019 Mar 27.

Division of Urologic Surgery, Department of Surgery , and.

Aims: To use clustering analysis of patient symptoms to discover common patient subtypes in females and males with interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: Clinical variables included in the k-means clustering included the severity of urologic pain (0-10 numeric rating scale, NRS), urinary urgency (0-10 NRS), frequency (0-10 NRS), non-urologic pain (0-10 NRS), and either a yes or no to each of the six UPOINT domains.

Results: 211 UCPPS patients seeking care of their IC/BPS or CP/CPPS were included. Read More

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http://dx.doi.org/10.1097/JU.0000000000000250DOI Listing
March 2019
1 Read

Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical Prostatitis or Prostate Cancer in Repeat Biopsies.

Urology 2019 Mar 23. Epub 2019 Mar 23.

Department of Urology, University of Illinois at Chicago, Chicago, IL. Electronic address:

Objectives: To evaluate whether the presence of basal cell hyperplasia (BCH) in negative biopsies is associated with concurrent lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), clinical prostatitis, and future prostate cancer (PCa) in repeat prostate biopsy.

Methods: We performed a retrospective analysis of 6471 men, 50-75 years old with prostate-specific antigen between 2.5 and 10 ng/ml and prior negative biopsy who were enrolled in the Reduction by Dutasteride of PCa Events trial and underwent a 2-year repeat biopsy. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.034DOI Listing
March 2019
1 Read

Diagnostic Performance of Multiparametric MR Imaging at 3.0 Tesla in Discriminating Prostate Cancer from Prostatitis: A Histopathologic Correlation.

Eurasian J Med 2019 Feb 30;51(1):31-37. Epub 2018 Nov 30.

Department of Radiology, Ankara University School of Medicine, Ankara, Turkey.

Objective: To investigate the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI) in differentiating prostate cancer (PCa) from prostatitis foci.

Materials And Methods: This retrospective analysis included 81 biopsy-proven lesions (44 prostatitis and 37 PCa). Normalized T2-signal intensity (nT2SI) and SI on diffusion-weighted imaging (b=1000 and 2000 mm/s), apparent diffusion coefficient (ADC) values, peak SI, SI at the end of the dynamic curves, mean peak time, mean enhancement percentage, and washout percentage obtained from dynamic contrast-enhanced imaging (DCEI) were measured. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2018.18195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422624PMC
February 2019
1 Read

Consequences of interleukin 1β-triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4 infiltration mimics human proliferative inflammatory atrophy.

Prostate 2019 May 22;79(7):732-745. Epub 2019 Mar 22.

Department of Biological Sciences, University of Maryland, Baltimore, Maryland.

Background: Elevated expression of the proinflammatory cytokine interleukin 1β (IL-1β) has been observed in expressed prostatic secretions of patients with chronic prostatitis/chronic pelvic pain syndrome, and genetic polymorphisms associated with the IL1B gene are linked to increased risk for aggressive prostate cancer.

Methods: To study the role of IL-1β expression in prostate inflammation, we examined IL1B expression in human prostatic proliferative inflammatory atrophy (PIA) lesions and developed a tetracycline-regulated human IL1B transgene in the mouse prostate.

Results: Here, we demonstrate that IL1B expression is a common finding in human PIA lesions, which harbored focal IL1B expression in epithelial and stromal compartments. Read More

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http://dx.doi.org/10.1002/pros.23784DOI Listing
May 2019
1 Read

Overexpression of lncRNA GAS5 suppresses prostatic epithelial cell proliferation by regulating COX-2 in chronic non-bacterial prostatitis.

Cell Cycle 2019 Mar 20:1-9. Epub 2019 Mar 20.

a Department of Urology , The First Affiliated Hospital of Soochow University , Suzhou , Jiangsu , China.

Chronic non-bacterial prostatitis (CNP) is a common urologic disease that is linked to the development of prostate cancer. Long non-coding RNA (lncRNA) GAS5 has been identified to mediate cell proliferation in prostate cancer, although its role in CNP is still unclear. Human prostate epithelial cell line RWPE-1 was induced by lipopolysaccharide (LPS) to mimic CNP model in vitro. Read More

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https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1
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http://dx.doi.org/10.1080/15384101.2019.1593644DOI Listing
March 2019
6 Reads

IL-10 Producing B Cells Dampen Protective T Cell Response and Allow Infection of the Male Genital Tract.

Front Immunol 2019 1;10:356. Epub 2019 Mar 1.

Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Córdoba, Argentina.

A significant proportion of individuals develop chronic, persistent and recurrent genital tract infections with , which has been attributed to the numerous strategies that the bacterium uses to subvert host immune responses. Animal chlamydia models have demonstrated that protective immune response is mediated by CD4 Th1 cytokine responses. Herein, we demonstrate that early after infecting the male genital tract, triggers the production of IL-10 by splenic and lymph node cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405527PMC
March 2019
1 Read

[The influence of physical activity as an alternative treatment to chronic prostatitis: A meta-analysis].

Rev Int Androl 2019 Mar 11. Epub 2019 Mar 11.

Departamento de Enfermería, Facultad de Educación y Salud, Universidad Camilo José Cela, Villanueva de la Cañada, Madrid, España.

Introduction: Chronic prostatitis is one of the most common diagnoses in outpatient clinics in Urology. It is presented as a heterogeneous group of diseases, whose etiology is often unknown, showing as a common denominator a set of painful, irritative and obstructive symptoms of the genitourinary tract and perineum.

Objectives: A systematic review and updated meta-analysis of this pathology was performed in relation to the damages or benefits that physical activity could have in chronic prostatitis or chronic pelvic pain. Read More

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http://dx.doi.org/10.1016/j.androl.2018.12.001DOI Listing
March 2019
4 Reads

Male CP/CPPS: where do we stand?

World J Urol 2019 Mar 12. Epub 2019 Mar 12.

Department of Urology, Queen's University, Empire 4, Kingston General Hospital, 76 Stuart St, Kingston, ON, K7L 2V7, Canada.

Introduction: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), commonly encountered in urologic practice, carries with it a stigma of poor understanding, ineffective treatment, and significant financial and quality of life burden.

Materials And Methods: This clinically practical review is based on the authors' personal clinical experience in interpretation and application of currently available evidence.

Results: Significant progress has been made in terms of classification and evaluation of the disease, leading to encouraging improvements in treatment outcomes. Read More

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http://link.springer.com/10.1007/s00345-019-02718-6
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http://dx.doi.org/10.1007/s00345-019-02718-6DOI Listing
March 2019
6 Reads

Giant Prostate Utricle Cyst.

J Belg Soc Radiol 2019 Feb 5;103(1):17. Epub 2019 Feb 5.

UZ Gent, BE.

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http://dx.doi.org/10.5334/jbsr.1738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396040PMC
February 2019

The role of ethanol in the pathogenesis of non‑bacterial prostatitis.

Mol Med Rep 2019 May 27;19(5):3848-3854. Epub 2019 Feb 27.

Department of Urology, Shanghai Fengxian District Central Hospital, Shanghai 201499, P.R. China.

Chronic prostatitis (CP) is a common disease within the field of urology, and it is difficult to treat. Prostatitis mainly occurs in young men and presents with various clinical symptoms, manifested as urinary frequency, urinary urgency, urinary pain, prolonged urination, dysuria and other urinary abnormalities. There are various forms of the syndrome that can cause discomfort or pain in the perineum, the lower abdomen, the penis, the scrotum and the lumbosacral area. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.9991
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http://dx.doi.org/10.3892/mmr.2019.9991DOI Listing
May 2019
23 Reads

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

BMJ 2019 02 27;364:l440. Epub 2019 Feb 27.

Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.

Objective: To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline recommendations.

Design: Cross sectional study.

Setting: General practices contributing to The Health Improvement Network database, 2013-15. Read More

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http://dx.doi.org/10.1136/bmj.l440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391655PMC
February 2019
2 Reads

Comparative Expression of RAGE and SOX2 in Benign and Malignant Prostatic Lesions

Asian Pac J Cancer Prev 2019 Feb 26;20(2):615-620. Epub 2019 Feb 26.

Department of Pathology, Theodor Bilharz Research Institute, Cairo, Egypt. Email:

Background: Prostate cancer (PCa) is a common health problem in elderly. RAGE (Receptor for advanced glycation end products) is overexpressed in multiple human cancers. SOX2 (Sex-determining region Y box 2) also functions as an oncoprotein and promotes cancer progression but the mechanisms involved remain largely unknown. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.615DOI Listing
February 2019
3 Reads

Roles of Species in Idiopathic Chronic Prostatitis: A Case-Control Study.

World J Mens Health 2019 Feb 12. Epub 2019 Feb 12.

Department of Urology, Dankook University College of Medicine, Cheonan, Korea.

Purpose: Because of the inconsistent symptoms associated with infections, their clinical significances in genitourinary tracts are under debate. Therefore, we evaluated the presence of (UU) and (UP) in urine samples and examined their associations with chronic prostatitis (CP) through a case and control study.

Materials And Methods: We included 696 nonchlamydial nongonococcal (NCNG) urine samples from men; 350 were categorized into non-inflammatory CP, 88 in inflammatory CP, and 258 in non-CP group. Read More

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http://dx.doi.org/10.5534/wjmh.180081DOI Listing
February 2019

Oral fosfomycin for the treatment of chronic bacterial prostatitis.

J Antimicrob Chemother 2019 Feb 22. Epub 2019 Feb 22.

1st Department of Internal Medicine & Infectious Diseases, Hygeia General Hospital, Athens, Greece.

Background: Chronic bacterial prostatitis (CBP) is a difficult-to-treat infection as only a few antibiotics achieve therapeutic concentrations in the prostate. Data on the efficacy and safety of oral fosfomycin for the treatment of CBP are limited.

Objectives: To analyse the efficacy and safety of fosfomycin in CBP due to MDR pathogens. Read More

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http://dx.doi.org/10.1093/jac/dkz015DOI Listing
February 2019
4 Reads

New therapy with XLQ to suppress chronic prostatitis through its anti-inflammatory and antioxidative activities.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.

Chronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions of XLQ in chronic nonbacterial prostatitis using a complete Freund's adjuvant-induced rat model. Read More

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http://dx.doi.org/10.1002/jcp.28380DOI Listing
February 2019
5 Reads

Impact of patient information leaflets on doctor-patient communication in the context of acute conditions: a prospective, controlled, before-after study in two French emergency departments.

BMJ Open 2019 Feb 20;9(2):e024184. Epub 2019 Feb 20.

Research Department, Grenoble Alpes University Hospital, Grenoble, France.

Objective: In the context of acute conditions seen in an emergency department, where communication may be difficult, patient information leaflets (PILs) could improve doctor-patient communication (DPC) and may have an impact on other outcomes of the consultation. Our objective was to assess the impact of PILs on DPC, patient satisfaction and adherence, and on patient and doctor behaviours.

Design: Prospective, controlled, before-after trial between November 2013 and June 2015. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398756PMC
February 2019
3 Reads

Association between child maltreatment and central sensitivity syndromes: a systematic review protocol.

BMJ Open 2019 Feb 19;9(2):e025436. Epub 2019 Feb 19.

School of Nursing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction: A growing body of evidence is identifying the link between a history of child maltreatment and a variety of adverse health outcomes ultimately leading to significant social and healthcare burden. Initial work has identified a potential association between child maltreatment and the development of a selection of somatic and visceral central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, temporomandibular joint disorder, chronic lower back pain, chronic neck pain, chronic pelvic pain, interstitial cystitis, vulvodynia, chronic prostatitis, tension-type headache, migraine, myofascial pain syndrome, irritable bowel syndrome and restless legs syndrome.

Methods And Analysis: Primary electronic searches will be performed in the Embase, MEDLINE, PubMed, Scopus, PyscINFO, CINAHL and Cochrane Library databases and a number of Grey Literature sources including child protection and paediatric conference proceedings. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02543
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http://dx.doi.org/10.1136/bmjopen-2018-025436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368161PMC
February 2019
6 Reads

Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer.

BMC Genomics 2019 Feb 18;20(1):146. Epub 2019 Feb 18.

Vancouver Prostate Centre, Vancouver, Canada.

Background: Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries. Since most precancerous and cancerous tissues show signs of inflammation, chronic bacterial prostatitis has been hypothesized to be a possible etiology. However, establishing a causal relationship between microbial inflammation and PCa requires a comprehensive analysis of the prostate microbiome. Read More

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http://dx.doi.org/10.1186/s12864-019-5457-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379980PMC
February 2019
3 Reads

Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis.

J Pharmacol Sci 2019 Mar 2;139(3):201-208. Epub 2019 Feb 2.

Department of Pharmacy, School of Life and Health Science, Anhui Science and Technology University, Fengyang, Anhui, People's Republic of China. Electronic address:

Objectives: The therapeutic potentiality of Bazhengsan on the chronic nonbacterial prostatitis was investigated.

Methods: Prostatitis was induced by subcutaneous injection of the 17-beta-estradiol (E) and dihydrotestosterone in male rat, and treated with Bazhengsan. After 8 weeks, prostatic fluid was collected for counting lecithin corpuscle density (LCD) and the organs were removed from animals and used for measuring prostate viscera coefficient (PVC). Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.007DOI Listing
March 2019
2 Reads

Chronic prostatitis caused by extended-spectrum β-lactamase-producing managed using oral fosfomycin-A case report.

IDCases 2019 24;15:e00493. Epub 2019 Jan 24.

Faculty of Medicine of the University of Porto, Infectious Diseases department, Centro Hospitalar de São João, Porto, Portugal.

Prostatitis is a clinical condition of difficult management and with limited antimicrobial options, especially in the setting of antimicrobial resistance. Recurrences are frequent and can be severe. Limited reports support the use of fosfomycin for chronic prostatitis by ESBL-producing bacteria. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360601PMC
January 2019
2 Reads

[The effectiveness of the integrated approach to the treatment of chronic prostatitis, including in patients with benign prostatic hyperplasia].

Urologiia 2018 Oct(4):81-87

I.P. Pavlov Ryazan State Medical University of Minzdrav of Russia, Ryazan, Russia.

Introduction: Concurrent chronic prostatitis (CP) plays an important role in the pathogenesis and progression of benign prostatic hyperplasia (BPH), increasing the severity of lower urinary tract symptoms (LUTS), lowering the quality of life, and increasing the risk of acute urinary retention. However, in the management of patients with BPH, the role of CP is not always taken into account.

Aim: To evaluate the effectiveness of integrated management of patients with CP and patients with co-occurring BPH and CP using a physiotherapeutic device Mavit for the treatment of inflammatory diseases of the prostate. Read More

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October 2018
5 Reads

[Patients with newly diagnosed benign prostatic hyperplasia].

Urologiia 2018 Oct(4):72-80

Novosibirsk TB Research Institute of Minzdrav of Russia, Novosibirsk, Russia.

The study aimed to characterize patients with newly diagnosed benign prostatic hyperplasia (BPH) and identify patterns that lead to late diagnosis of the disease.

Study Design: Simple open retrospective non-comparative study.

Material And Methods: To determine the frequency of requests for medical care for BPH, the study analyzed medical records of 3544 patients who sought outpatient urological care at the municipal polyclinic # 26 in Novosibirsk in 2013. Read More

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October 2018

[Rationale of use and effectiveness of Longidaza in patients with chronic prostatitis].

Urologiia 2018 Oct(4):64-71

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia, Novosibirsk, Russia.

Introduction: Chronic inflammation of the prostate leads to the formation of excess fibrous connective tissue, which hinders patients recovery and aggravates the symptoms.

Aim: This study aimed to confirm the correlation between inflammation and prostatic fibrosis and the abnormalities of urodynamic and microcirculation in the prostate gland in humans, and the possibility of increasing the effectiveness of treatment of patients with chronic nonbacterial prostatitis using antisclerotic therapy.

Material And Methods: The study was carried out in two stages. Read More

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October 2018
2 Reads