7,979 results match your criteria Chronic Bacterial Prostatitis


Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis.

J Immunol Res 2022 17;2022:6833867. Epub 2022 Jun 17.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 Hubei, China.

Purpose: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological disorder. Although ferroptosis is closely associated with inflammation, oxidative stress, and neuropathic pain, its role in CP/CPPS has not yet been elucidated. Therefore, we sought to explore the role and mechanism of ferroptosis in the prostatitis development. Read More

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Low quality of life in men with chronic prostatitis-like symptoms.

Prostate Cancer Prostatic Dis 2022 Jun 25. Epub 2022 Jun 25.

Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Chronic prostatitis (CP) can impair health-related quality of life (QOL), but the full impact of CP, including the impact of CP-like symptoms in men who have no CP diagnosis (CPS), is unknown. We estimated the impact of diagnosed CP (DCP) and CPS on Health-related QOL.

Methods: From a representative nationwide survey of men aged 20-84 in Japan, we determined the prevalence of DCP and also of CPS. Read More

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Efficacy and safety of selective serotonin reuptake inhibitors for chronic prostatitis/chronic pelvic pain syndrome: A systematic review and network meta-analysis.

Asian J Surg 2022 Jun 20. Epub 2022 Jun 20.

Second Clinical Medical College, Lanzhou University, Lanzhou, China; Department of Urology, Lanzhou University Second Hospital, Lanzhou, China. Electronic address:

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A rat study model of depression-driven chronic prostatitis by modulating the PI3K/Akt/mTOR network.

Andrologia 2022 Jun 21:e14488. Epub 2022 Jun 21.

Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Depression and chronic prostatitis (CP) are two common diseases that affect the human population worldwide. Clinically, it has been demonstrated that andrological patients often simultaneously suffer from depression and CP. Prior investigations have established that depression acts as an independent risk factor for CP. Read More

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A Review on Canine and Feline Prostate Pathology.

Front Vet Sci 2022 26;9:881232. Epub 2022 May 26.

School of Veterinary Medicine and Animal Science, Sao-Paulo State University-UNESP, Botucatu, Brazil.

Prostatic diseases are very common in male dogs, accounting for 3-10% of cases submitted to the veterinary practitioners. Commonly reported canine prostatic disorders include prostatic hyperplasia, prostatitis, prostatic cysts and prostatic carcinoma. However, clinical signs may be non-specific, or many cases are asymptomatic, thus leading to a difficult estimation of the actual prevalence of clinical cases. Read More

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[Vitamin B12 is a diagnostic marker of decreased men reproductive function].

Biomed Khim 2022 Jun;68(3):228-231

Academician I.P. Pavlov Ryazan State Medical University, Ryazan, Russia.

Although the relationship between the amount of vitamin B12 and the quality of sperm exists, but results are controversial and require several additional research. The objective of our study was to analyse the amount of vitamin B12 in the sperm samples from patients with chronic prostatitis and varicocele with accompanying asthenozoospermia, and to identify the relationship between the amount of vitamin B12 and asthenozoospermia. The research was carried out of men with chronic prostatitis and varicocele with accompanying asthenozoospermia and infertility at the age of 27±2 years. Read More

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How I manage bacterial prostatitis.

Clin Microbiol Infect 2022 Jun 13. Epub 2022 Jun 13.

Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.

Background: Bacterial prostatitis is a highly prevalent infection responsible for significant morbidity among men. The diagnosis and treatment for bacterial prostatitis remains complicated. The difficulty in diagnosis is in part owing to the paucity of high quality evidence that guides a clinician's physical examination and informs interpretation of laboratory data in confirming patients' history. Read More

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Oral pharmacological treatments for chronic prostatitis/chronic pelvic pain syndrome: A systematic review and network meta-analysis of randomised controlled trials.

EClinicalMedicine 2022 Jun 20;48:101457. Epub 2022 May 20.

Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Pharmacological treatments for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are empirically used. However, the quantitative comparative effectiveness and safety of multiple pharmacological treatments is lacking.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched from inception to March 22, 2022. Read More

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CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation.

Prostate 2022 Jun 14. Epub 2022 Jun 14.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) is an inflammatory immune disease that is characterized by infiltrating inflammatory cells in the prostate and pelvic or by perineal pain. Receptor CXCR3modulates immune and inflammatory responses; however, the effects of CXCR3 antagonist AMG487 in the context of CP/CPPS are unknown. Therefore, we investigated the effect of AMG487 in experimental autoimmune prostatitis (EAP) mice and explored the potential functional mechanisms. Read More

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Transperitoneal Laparoscopic Unroofing versus Fenestration Under Seminal Vesiculoscopy for Seminal Vesicle Cyst, a Multi-Institutional Retrospective Cohort Study.

Int J Gen Med 2022 7;15:5547-5556. Epub 2022 Jun 7.

The Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Background: To illustrate the transperitoneal laparoscopic unroofing (TLU) and compare the efficacy and safety of TLU to fenestration under seminal vesiculoscopy (FUSV) in treating symptomatic seminal vesicle cyst (SVC).

Methods: We retrospectively reviewed all patients with symptomatic SVC who underwent TLU or FUSV between 2008 and 2020 at 3 institutions in Hunan. The two groups were evaluated with reference to radiological failure-free survival (R-FFS), fertility outcome, symptoms, and complications at a median 33. Read More

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HA/CD44 Regulates the T Helper 1 Cells Differentiation by Activating Annexin A1/Akt/mTOR Signaling to Drive the Pathogenesis of EAP.

Front Immunol 2022 26;13:875412. Epub 2022 May 26.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

CD44 partcipates in multiple inflammatory reactions. Here, we aimed to investigate the role of CD44 and the ligand, hyaluronan (HA), on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) pathogenesis. We found that CD44 was universally expressed in CD4 lymphocytes in the peripheral blood of CP/CPPS patients. Read More

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Acupuncture for female bladder pain syndrome: a randomized controlled trial.

Can J Urol 2022 Jun;29(3):11154-11161

Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.

Introduction: Growing evidence supports acupuncture for several pain conditions including chronic prostatitis. This study aimed to determine the safety, tolerability, and effectiveness of acupuncture in reducing pain in women with interstitial cystitis/bladder pain syndrome (IC/BPS).

Materials And Methods: This prospective randomized single-blinded study compared electro-acupuncture (EA) to minimal acupuncture (MA) after 6 weekly treatments and again after 6 weeks of no treatment. Read More

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P2 purinergic receptor dysregulation in urologic disease.

Purinergic Signal 2022 Jun 10. Epub 2022 Jun 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

P2 purinergic receptors are involved in the normal function of the kidney, bladder, and prostate via signaling that occurs in response to extracellular nucleotides. Dysregulation of these receptors is common in pathological states and often associated with disease initiation, progression, or aggressiveness. Indeed, P2 purinergic receptor expression is altered across multiple urologic disorders including chronic kidney disease, polycystic kidney disease, interstitial cystitis, urinary incontinence, overactive bladder syndrome, prostatitis, and benign prostatic hyperplasia. Read More

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Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in-depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.

Neurourol Urodyn 2022 Jun 10. Epub 2022 Jun 10.

Department of Surgery, Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Introduction: There has been a sparse exploration of the lived experience of men with urologic chronic pelvic pain syndrome (UCPPS), and none with the goal of Investigating the experience of "flares" as part of this chronic pain syndrome in men.

Methods: We conducted three focus groups of male UCPPS patients at two sites of the MAPP Research Network (n = 16 total participants) to explore the full spectrum of flares and their impact on men's lives.

Results: Flare experiences were common and specific symptom components varied widely. Read More

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Dietary habits and lifestyle related to the effectiveness of low-intensity extracorporeal shock wave therapy for chronic prostatitis/chronic pelvic pain syndrome-like symptoms: Initial results.

Andrologia 2022 Jun 7:e14490. Epub 2022 Jun 7.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China.

To identify factors that could influence the treatment outcomes of low-intensity extracorporeal shock wave therapy (Li-ESWT) on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)-like symptoms and establish a predictive model based on these factors to precisely screen individuals who might be more suitable for Li-ESWT. This study enrolled 84 patients with CP/CPPS-like symptoms who received Li-ESWT. Patients were divided into an effective group and an ineffective group based on the reduction of their National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Read More

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PD-L1 positive lympho-epithelial lesions in inflammatory prostate.

Histol Histopathol 2022 Jun 7:18479. Epub 2022 Jun 7.

Department of Medical Biology, Research Institute at Medical Faculty, Medical University of Plovdiv, Bulgaria.

Objectives: Ductal epithelial changes (lympho-epithelial lesions-LEL) in prostatic chronic inflammation (CI) are not well studied so far.

Aim: to investigate LEL immediately adjacent to prostatic CI.

Methods: We studied LEL in 144 prostatic surgical and autopsy specimens in various types of prostatic CI: NIH-category IV prostatitis (histologic prostatitis-HP), nonspecific granulomatous prostatitis (NSGP), and the reactive lymphoid infiltrates in the vicinity of benign prostatic hyperplasia (BPH) and prostate adenocarcinoma (PCa). Read More

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Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-β/SMAD signaling pathway.

Biomed Pharmacother 2022 Aug 2;152:113193. Epub 2022 Jun 2.

Department of Traditional Chinese Medicine Surgery, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, No. 445 Bayi Avenue, Nanchang 330006, China. Electronic address:

Background: Chronic non-bacterial prostatitis (CNBP) accounts for more than 90 % of clinical prostatitis cases, and there is no specific and effective treatment for CNBP. The regulatory role of Jiedu Huoxue decoction (JDHXD)in CNBP remains unclear. We investigated if JDHXD could improve CNBP METHODS: The animal model of CNBP was established by carrageenan injection with 1 % carrageenan (50 μL). Read More

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Treatment with the soluble guanylate cyclase activator BAY 60-2770 normalizes bladder function in an in vivo rat model of chronic prostatitis.

Eur J Pharmacol 2022 Jul 26;927:175052. Epub 2022 May 26.

Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Background And Purpose: Chronic pelvic pain syndrome (CPPS) is a common and bothersome condition for which no pharmacological treatment options with acceptable efficacy exist. The aim of this study was to investigate the effects of the soluble guanylate cyclase (sGC) activator BAY 60-2770 and the COX-2 inhibitor celecoxib on bladder function in a rat model of CPPS.

Experimental Approach: Forty-eight male Sprague-Dawley rats were intraprostatically injected with either saline, serving as control, or zymosan, to induce prostatitis. Read More

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Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of in Rats.

Molecules 2022 May 19;27(10). Epub 2022 May 19.

Xinjiang Key Laboratory for Reserch of Licorice and Products, Korla 841011, China.

(1) Background: The aerial part of had pharmacological effects against chronic non-bacterial prostatitis (CNP), and flavonoids are the main efficacy components. The purpose of this study was to obtain the pharmacokinetics, prostate distribution and metabolic characteristics of some flavonoids in rats. (2) Methods: The prototype flavones and the metabolites of four representative flavonoids, namely puerarin, luteolin, kaempferol and pinocembrin in plasma, prostate, urine and feces of rats were analyzed by UPLC-Q-Exactive Orbitrap-MS. Read More

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Loss of the Sympathetic Signal Produces Sterile Inflammation of the Prostate.

Front Mol Neurosci 2022 10;15:855376. Epub 2022 May 10.

Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Neural innervations exert essential roles in the prostate. However, spatial distribution and regulatory function of such neural inputs are incompletely characterized. Here, we exploited the advanced whole-tissue immunolabeling and optical clearing technique to assess the 3D anatomy of autonomic innervations in the mouse and human prostate for the first time. Read More

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[A Case of Massive Prostate Abscess Treated by Transperineal Drainage].

Hinyokika Kiyo 2022 Apr;68(4):123-127

The Department of Urology, National Defense Medical College.

The patient was an 81-year-old man who visited a clinic for fever and lower abdominal pain. He was subsequently diagnosed with prostatitis based on computed tomography (CT) findings that showed swelling of the prostate. Despite treatment with antibacterial therapy, his symptoms did not improve significantly. Read More

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Coved and Saddleback ST-Segment Elevations: Brugada Phenocopy vs Brugada Syndrome.

Cureus 2022 Apr 21;14(4):e24338. Epub 2022 Apr 21.

Hospital Medicine, Zucker School of Medicine, Hempstead, USA.

We report a case of a middle-aged man who presented with near syncope, fever, and dysuria and was incidentally found to have coved ST-segment elevations in leads V1 and V2 confirming Brugada type 1 ECG (electrocardiogram) pattern. This ECG pattern morphed into saddleback ST-segment elevations in precordial leads consistent with type 2 Brugada the following day. Additionally, the patient reported a positive family history of sudden cardiac death. Read More

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Investigating the multi-target therapeutic mechanism of Guihuang formula on Chronic Prostatitis.

J Ethnopharmacol 2022 Aug 14;294:115386. Epub 2022 May 14.

Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Chronic prostatitis (CP) is a complex, intractable and prevalent urological disorder in men with no effective treatment. Guihuang formula (GHF) is a traditional Chinese medicine compound that is advantageous as a CP treatment, but its aetiology is poorly understood. Research and exploration of the mechanism of GHF will help the development of a potentially valuable drug for CP and provide deeper insight into CP. Read More

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Impaired Ability to Relax Pelvic Floor Muscles in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

Phys Ther 2022 May 14. Epub 2022 May 14.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, 90033, USA.

Objective: Excessive pelvic floor muscle activity has been suggested as a source of pain in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Our objective was to determine whether men with CP/CPPS have changes in neural drive that impair their ability to relax pelvic floor muscles.

Methods: We recruited 90 men (42 with CP/CPPS and 48 in the control group [without a history of pelvic pain]). Read More

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Pharmacotherapeutic interventions for the treatment of bacterial prostatitis.

Expert Opin Pharmacother 2022 Jun 27:1-11. Epub 2022 Jun 27.

Department of Infectious Diseases, Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Introduction: Bacterial prostatitis, acute or chronic, is one of the most prevalent urogenital infections in men. Its diagnosis requires the application of a careful methodology. Gram-negative bacilli are the most frequent causative agents, and in recent years, an increase in the frequency of multiresistant bacteria has been detected. Read More

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Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

Pain Res Manag 2022 4;2022:9448620. Epub 2022 May 4.

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Evidence shows that chronic prostatitis/chronic pelvic pain syndrome hugely impacts the body and mind. The central mechanisms in patients with CP/CPPS resulted in increased attention as neuroimaging techniques developed. This review investigated the study design and major neuroimaging findings in CP/CPPS patients to provide comprehensive evidence. Read More

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Molecular Effects of Low-Intensity Shock Wave Therapy on L6 Dorsal Root Ganglion/Spinal Cord and Blood Oxygenation Level-Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Changes in Capsaicin-Induced Prostatitis Rat Models.

Int J Mol Sci 2022 Apr 25;23(9). Epub 2022 Apr 25.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Neurogenic inflammation and central sensitization play a role in chronic prostatitis/chronic pelvic pain syndrome. We explore the molecular effects of low-intensity shock wave therapy (Li-ESWT) on central sensitization in a capsaicin-induced prostatitis rat model. Male Sprague-Dawley rats underwent intraprostatic capsaicin (10 mM, 0. Read More

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IL-17 exacerbates experimental autoimmune prostatitis via CXCL1/CXCL2-mediated neutrophil infiltration.

Andrologia 2022 May 12:e14455. Epub 2022 May 12.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a poorly understood disease. Accumulating evidence suggests that autoimmune dysfunction is involved in the development of CP/CPPS. Interleukin-17 (IL-17) is associated with the occurrence and development of several chronic autoimmune inflammatory diseases. Read More

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False-positive mpMRI and true-negative Ga-PSMA PET/CT xanthogranulomatous prostatitis: a case report.

Transl Androl Urol 2022 Apr;11(4):561-566

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, China.

Background: Xanthogranulomatous prostatitis (XGP) is a rare disorder of the prostate. It presents as a hard fixed nodule on digital rectal examination (DRE), and may cause obstructive urinary symptoms and elevated serum prostate-specific antigen (PSA) levels, therefore mimicking prostate cancer (PCa) clinically and biochemically. Radiological features of XGP overlap with those of PCa, and the 2 conditions cannot be distinguished by pelvic multiparametric magnetic resonance imaging (mpMRI). Read More

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