9,190 results match your criteria Chronic Fatigue Syndrome


Functional gastrointestinal and somatoform symptoms five months after SARS-CoV-2 infection: A controlled cohort study.

Neurogastroenterol Motil 2021 Jun 1:e14187. Epub 2021 Jun 1.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Gastrointestinal infections represent a risk factor for functional gastrointestinal and somatoform extraintestinal disorders. We investigated the prevalence and relative risk (RR) of gastrointestinal and somatoform symptoms 5 months after SARS-CoV-2 infection compared with a control cohort.

Methods: One hundred and sixty-four SARS-CoV-2 infected patients and 183 controls responded to an online questionnaire about symptoms and signs during the acute phase of the infection and after 4. Read More

View Article and Full-Text PDF

Intravenous Iron-Induced Hypophosphatemia: An Emerging Syndrome.

Adv Ther 2021 May 30. Epub 2021 May 30.

AMAG Pharmaceuticals Inc., Waltham, MA, USA.

Some, but not all, intravenous iron formulations have been recognized to induce renal phosphate wasting syndrome. Most commonly this has been reported following treatment of iron deficiency anemia (IDA) with ferric carboxymaltose (FCM). A search of PubMed identified relevant randomized controlled trials (RCTs), and case studies evaluating hypophosphatemia (HPP) resulting from intravenous iron treatment. Read More

View Article and Full-Text PDF

Pain and fatigue are predictors of quality of life in primary Sjögren's syndrome.

Adv Rheumatol 2021 05 29;61(1):28. Epub 2021 May 29.

Department of Clinical Medicine, Cassiano Antonio Moraes University Hospital / EBSERH, Federal University of Espírito Santo (Ufes), Av. Marechal Campos, 1468, Maruípe, Vitória, ES, CEP: 29075-910, Brazil.

Background: Few studies have evaluated the relation of quality of life (QoL) with symptoms and disease activity in primary Sjögren's syndrome (pSS). There is also scant information on the predictors of QoL in this population. The aim of this study was to assess QoL in patients with pSS and to investigate their possible predictors. Read More

View Article and Full-Text PDF

Skeletal muscle weakness in older adults home-restricted due to COVID-19 pandemic: a role for full-body in-bed gym and functional electrical stimulation.

Aging Clin Exp Res 2021 May 28. Epub 2021 May 28.

CIR-Myo-Interdepartmental Research Center of Myology, University of Padova, Padua, Italy.

Persons suffering with systemic neuromuscular disorders or chronic organ failures, spend less time for daily physical activity, aggravating their mobility impairments. From 2020, patients at risk are also older adults, who, though negative for the SARS-Cov-2 infection, suffer with a fatigue syndrome due to home restriction/quarantine. Besides eventual psycological managements, it could be useful to offer to these patients a rehabilitation workouts easy to learn and to independently repeat at home (Full-Body In-Bed Gym). Read More

View Article and Full-Text PDF

Cognitive behaviour therapy for chronic fatigue syndrome: Authors' reply, naturalistic outcomes paper.

J R Soc Med 2021 Jun 27;114(6):285-286. Epub 2021 May 27.

Department of Psychological Medicine, King's College London, UK.

View Article and Full-Text PDF

[Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved].

Authors:
F J Carod-Artal

Rev Neurol 2021 06;72(11):384-396

Universitat Internacional de Catalunya, Barcelona, España.

Introduction: Many patients with mild or severe COVID-19 do not make a full recovery and have a wide range of chronic symptoms for weeks or months after infection, often of a neurological, cognitive or psychiatric nature. The epidemiological evidence, diagnostic criteria and pathogenesis of post-COVID-19 syndrome are reviewed.

Development: Post-COVID-19 syndrome is defined by persistent clinical signs and symptoms that appear while or after suffering COVID-19, persist for more than 12 weeks and cannot be explained by an alternative diagnosis. Read More

View Article and Full-Text PDF

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4):113-120

Sechenov First Moscow State Medical University, Moscow, Russia.

The article presents a modern ecological approach to the pathogenesis and treatment of chronic fatigue syndrome (CFS). CFS is views in terms of gene-environment concept. The basic data in patients with CFS, triggers of diseases that implement the mechanisms responsible for the manifestation of symptoms are presented. Read More

View Article and Full-Text PDF

Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis.

EClinicalMedicine 2021 Jun 24;36:100899. Epub 2021 May 24.

Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London W2 1NY, UK.

Background: A significant proportion of individuals experience lingering and debilitating symptoms following acute COVID-19 infection. The National Institute for Health and Care Excellence (NICE) have coined the persistent cluster of symptoms as post-COVID syndrome. This has been further sub-categorised into acute post-COVID syndrome for symptoms persisting three weeks beyond initial infection and chronic post-COVID syndrome for symptoms persisting beyond twelve weeks. Read More

View Article and Full-Text PDF

Long-COVID Headache.

SN Compr Clin Med 2021 May 20:1-3. Epub 2021 May 20.

Residency Program, Internal Medicine, Sapienza University of Rome, Rome, Italy.

The so-called long COVID-19 is a set of symptoms that accompanies the patient even for months after discharge from the hospital. These symptoms include easy muscle fatigue, moderate breathlessness, persistent headache, the feeling of a foggy head, and the development of psychiatric disorders. In general, the quality of life of at least half of the patients who come out of the COVID-19 syndrome, both mild and severe, shows a markedly worsening despite having passed a difficult physical and psychological test. Read More

View Article and Full-Text PDF

[Practical recommendations for the management of testosterone deficiency].

Prog Urol 2021 Jun-Jul;31(8-9):458-476. Epub 2021 May 24.

Médecine de la reproduction, CHU de Toulouse, site de Paule-de-Viguier, Toulouse, France; Département d'urologie, transplantation rénale et andrologie, hôpital Rangueil, CHU de Toulouse, France. Electronic address:

Objectives: The Francophone Society of Sexual Medicine (SFMS) and the Andrology and Sexual Medicine Committee (CAMS) of the French Association of Urology (AFU) have brought together a panel of experts to develop French recommendations for the management of testosterone deficiency (TD).

Methods: Systematic review of the literature between 01/2000 and 07/2019. Use of the method of recommendations for clinical practice (RPC) and the AGREE II grid. Read More

View Article and Full-Text PDF

Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Front Med (Lausanne) 2021 7;8:672370. Epub 2021 May 7.

Analytical Chemistry and Neurochemistry, Department of Chemistry-Biomedical Center, Uppsala University, Uppsala, Sweden.

We here provide an overview of treatment trials for intensive care unit (ICU) patients and theorize about their relevance for potential treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these treatment trials generally target: (a) the correction of suppressed endocrine axes, notably through a "reactivation" of the pituitary gland's secretion of tropic hormones, or (b) the interruption of the "vicious circle" between inflammation, oxidative and nitrosative stress (O&NS), and low thyroid hormone . There are significant parallels in the treatment trials for critical illness and ME/CFS; this is consistent with the hypothesis of an overlap in the mechanisms that prevent recovery in both conditions. Read More

View Article and Full-Text PDF

Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments.

Authors:
Shin Jie Yong

Infect Dis (Lond) 2021 May 22:1-18. Epub 2021 May 22.

Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, Malaysia.

Long COVID or post-COVID-19 syndrome first gained widespread recognition among social support groups and later in scientific and medical communities. This illness is poorly understood as it affects COVID-19 survivors at all levels of disease severity, even younger adults, children, and those not hospitalized. While the precise definition of long COVID may be lacking, the most common symptoms reported in many studies are fatigue and dyspnoea that last for months after acute COVID-19. Read More

View Article and Full-Text PDF

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data.

Front Med (Lausanne) 2021 4;8:653516. Epub 2021 May 4.

IRCCS Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Bologna, Italy.

Whilst the entire world is battling the second wave of COVID-19, a substantial proportion of patients who have suffered from the condition in the past months are reporting symptoms that last for months after recovery, i. e., long-term COVID-19 symptoms. Read More

View Article and Full-Text PDF

Editorial: The Pathogenesis of Long-Term Neuropsychiatric COVID-19 and the Role of Microglia, Mitochondria, and Persistent Neuroinflammation: A Hypothesis.

Med Sci Monit 2021 May 10;27:e933015. Epub 2021 May 10.

Center for Cognitive and Molecular Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Persistent comorbidities occur in patients who initially recover from acute coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 'Long COVID' involves the central nervous system (CNS), resulting in neuropsychiatric symptoms and signs, including cognitive impairment or 'brain fog' and chronic fatigue syndrome. There are similarities in these persistent complications between SARS-CoV-2 and the Ebola, Zika, and influenza A viruses. Read More

View Article and Full-Text PDF

Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.

Sci Rep 2021 May 19;11(1):10604. Epub 2021 May 19.

Institute of Biomedical Science, Department of Health Studies, FH Joanneum University of Applied Sciences, Graz, Austria.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by unexplained debilitating fatigue. Although the etiology is unknown, evidence supports immunological abnormalities, such as persistent inflammation and immune-cell activation, in a subset of patients. Since the interplay between inflammation and vascular alterations is well-established in other diseases, endothelial dysfunction has emerged as another player in ME/CFS pathogenesis. Read More

View Article and Full-Text PDF

Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome.

J Proteome Res 2021 06 19;20(6):3315-3329. Epub 2021 May 19.

Australian National Phenome Centre, Health Futures Institute, Murdoch University, Harry Perkins Building, 5 Robin Warren Drive, Perth, WA 6150, Australia.

We present a multivariate metabotyping approach to assess the functional recovery of nonhospitalized COVID-19 patients and the possible biochemical sequelae of "Post-Acute COVID-19 Syndrome", colloquially known as long-COVID. Blood samples were taken from patients ca. 3 months after acute COVID-19 infection with further assessment of symptoms at 6 months. Read More

View Article and Full-Text PDF

Prevalence of growth hormone deficiency in patients with unexplained chronic fatigue after undergoing bone marrow transplantation in adulthood.

J Endocrinol Invest 2021 May 18. Epub 2021 May 18.

Division of Endocrinology, Department of Medicine, Cumming School of Medicine, University of Calgary, 1820 Richmond Rd SW, Calgary, AB, T2T 5C7, Canada.

Purpose: Many patients who undergo bone marrow transplantation (BMT) in adulthood experience unexplained chronic fatigue which can have a major impact on their health-related quality of life (QoL). Pre-BMT treatment regimens increase the risk of developing acquired growth hormone deficiency (GHD), which results in a clinical syndrome with decreased energy and has additionally been linked to metabolic syndrome.

Methods: Using the gold-standard insulin hypoglycemic test (IHT), we evaluated the prevalence of GHD in 18 post-BMT adult patients with unexplained chronic fatigue, as well as the correlation between peak serum GH response and QoL scores, the metabolic syndrome, and insulin resistance. Read More

View Article and Full-Text PDF

Fibromyalgia as a Heterogeneous Condition: Subgroups of Patients Based on Physical Symptoms and Cognitive-Affective Variables Related to Pain.

Span J Psychol 2021 May 18;24:e33. Epub 2021 May 18.

Universidad de Granada (Spain).

Fibromyalgia (FM) is a chronic syndrome characterized by heterogeneous clinical manifestations, and knowing this variability can help to develop tailored treatments. To understand better the heterogeneity of FM the present cross-sectional study analyzed the role of several physical symptoms (pain, fatigue and poor sleep quality) and cognitive-affective variables related to pain (pain catastrophizing, pain vigilance, self-efficacy in pain management, and pain acceptance) in the configuration of clinical profiles. A sample of 161 women with FM fulfilled an interview and several self-report measures to explore physical symptoms, cognitive-affective variables, disability and psychopathology. Read More

View Article and Full-Text PDF

One year in review 2021: fibromyalgia.

Clin Exp Rheumatol 2021 May 13. Epub 2021 May 13.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Italy.

Fibromyalgia (FM) is a syndrome of unknown aetiology characterised by chronic pain, fatigue, and disturbed sleep. This review presents and summarises the 2020 literature on FM by retrieving all articles indexed in PubMed between 1 January 2020 and 31 December 2020. The attention of the scientific community towards FM is constantly growing, and this year's review is focused on the diagnostic, pathogenetic and therapeutic aspects of this syndrome. Read More

View Article and Full-Text PDF

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, a mimicker of malignancy: a case report and review of the literature.

J Med Case Rep 2021 May 18;15(1):246. Epub 2021 May 18.

Long Beach Memorial Medical Center, Long Beach, CA, USA.

Background: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids is a clinically and radiographically distinct inflammatory syndrome affecting multiple structures of the brain, including the cerebellum, brainstem, and spinal cord. The clinical presentation can be variable, including ataxia, nystagmus, dysarthria, dysphagia, and other subacute brainstem, cranial nerve, or cerebellar symptoms. These symptoms can be subacute to chronic, episodic, and progressive, making the diagnosis challenging. Read More

View Article and Full-Text PDF

Comparison of the finger plethysmography derived stroke volumes by Nexfin CO Trek and suprasternal aortic Doppler derived stroke volume measurements in adults with myalgic encephalomyelitis/chronic fatigue syndrome and in healthy controls.

Technol Health Care 2021 Apr 25. Epub 2021 Apr 25.

Stichting CardioZorg, Hoofddorp, The Netherlands.

Background: Finger plethysmography derived stroke volumes are frequently measured during tilt table testing. There are two algorithms to determine stroke volumes: Modelflow and NexfinCO Trek. Most tilt studies used Modelflow, while there are differences between the two algorithms. Read More

View Article and Full-Text PDF

Adolescent and Young Adult ME/CFS After Confirmed or Probable COVID-19.

Front Med (Lausanne) 2021 29;8:668944. Epub 2021 Apr 29.

Departments of Pediatrics, The Johns Hopkins University School of Medicine and the Kennedy Krieger Institute, Baltimore, MD, United States.

Fatigue is a common acute symptom following SARS-CoV-2 infection (COVID-19). The presence of persistent fatigue and impaired daily physical and cognitive function has led to speculation that like SARS-CoV-1 infection, COVID-19 will be followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We describe three adolescent and young adult patients who had confirmed or probable COVID-19 infections early on during the pandemic and were referred for evaluation to the Chronic Fatigue Clinic at the Johns Hopkins Children's Center. Read More

View Article and Full-Text PDF

Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue.

J Mol Neurosci 2021 May 16. Epub 2021 May 16.

College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

In recent years, the incidence of fatigue has been increasing, and the effective prevention and treatment of fatigue has become an urgent problem. As a result, the genetic research of fatigue has become a hot spot. Transcriptome-level regulation is the key link in the gene regulatory network. Read More

View Article and Full-Text PDF

Epidemiology and organ specific sequelae of post-acute COVID19: A narrative review.

J Infect 2021 Jul 14;83(1):1-16. Epub 2021 May 14.

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States. Electronic address:

Objectives: "Long COVID", a term coined by COVID-19 survivors, describes persistent or new symptoms in a subset of patients who have recovered from acute illness. Globally, the population of people infected with SARS-CoV-2 continues to expand rapidly, necessitating the need for a more thorough understanding of the array of potential sequelae of COVID-19. The multisystemic aspects of acute COVID-19 have been the subject of intense investigation, but the long-term complications remain poorly understood. Read More

View Article and Full-Text PDF

Coombs-Negative Haemolytic Anaemia, Direct Hyperbilirubinaemia and Splenomegaly: A Rare Amalgam.

Eur J Case Rep Intern Med 2021 8;8(4):002477. Epub 2021 Apr 8.

UCONN Health, Farmington, CT, USA.

Introduction: Epstein-Barr virus (EBV) is notorious for its varied presentation in adults. Reactivation of EBV can occur at any time and is often due to weakened cellular immunity.

Case Description: Here we report the case of a young woman with no previous medical history who presented with cholestatic hepatitis, Coombs-negative haemolytic anaemia and splenomegaly. Read More

View Article and Full-Text PDF

COVID and Cardiovascular Disease: What We Know in 2021.

Curr Atheroscler Rep 2021 05 13;23(7):37. Epub 2021 May 13.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose Of Review: Coronavirus disease 2019 (COVID-19) has been the cause of significant global morbidity and mortality. Here, we review the literature to date of the short-term and long-term consequences of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the heart.

Recent Findings: Early case reports described a spectrum of cardiovascular manifestations of COVID-19, including myocarditis, stress cardiomyopathy, myocardial infarction, and arrhythmia. Read More

View Article and Full-Text PDF

Long COVID-19: an emerging pandemic in itself.

Adv Respir Med 2021 ;89(2):234-236

Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

View Article and Full-Text PDF