1,236 results match your criteria Chromoblastomycosis

Pathogenicity and Growth Conditions Modulate Extracellular Vesicles' Ability to Interact With Macrophages.

Front Cell Infect Microbiol 2022 9;12:879018. Epub 2022 Jun 9.

Department of Cell Biology, University of Brasília, Brasília, Brazil.

Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous mycosis caused by black, dimorphic, and filamentous fungi of the family, such as species of the genus . These fungi can switch between the saprophytic forms (conidia and hyphae) and the pathogenic form, the muriform cells (MCs), which is considered an essential mechanism for fungal virulence. Nearly all types of cells can produce membranous structures formed by a lipid bilayer that communicate extracellularly with other cells, known as "extracellular vesicles" (EVs), which may act as virulence factors, as observed for several species of pathogenic fungi. Read More

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Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of Fonsecaea monophora.

PLoS Negl Trop Dis 2022 Jun 13;16(6):e0010485. Epub 2022 Jun 13.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Dematiaceous Fonsecaea monophora is one of the major pathogens of chromoblastomycosis. It has been well established that melanization is catalyzed by the type I polyketide synthase (PKS) in F. monophora. Read More

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Photodynamic therapy, a promising treatment approach for cutaneous infectious granulomas.

Photodiagnosis Photodyn Ther 2022 Jun 9:102952. Epub 2022 Jun 9.

The Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Jining 272000, Shandong, China; Department of Dermatology, Jining No.1 People's Hospital, Jining 272001, Shandong, China. Electronic address:

Cutaneous infectious granulomas are mainly caused by fungi and bacteria. Antibiotics are the primary therapeutic choices for the diseases, but the drug-resistant pathogens become increasingly prevalent. Thus, there is an urgent need to explore novel approaches to treating cutaneous infectious granulomas. Read More

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Accuracy of direct examination and culture as compared to the anatomopathological examination for the diagnosis of chromoblastomycosis: a systematic review.

An Bras Dermatol 2022 May 25. Epub 2022 May 25.

Department of Tropical Medicine and Dermatology Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: Chromoblastomycosis is a skin infection caused by dematiaceous fungi that take the form of muriform cells in the tissue. It mainly manifests as verrucous plaques on the lower limbs of rural workers in tropical countries.

Objectives: The primary objective of this review is to evaluate the accuracy of diagnostic methods for the identification of chromoblastomycosis, considering the histopathological examination as the reference test. Read More

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Pulmonary and Extrapulmonary Manifestations of Fungal Infections Misdiagnosed as Tuberculosis: The Need for Prompt Diagnosis and Management.

J Fungi (Basel) 2022 Apr 28;8(5). Epub 2022 Apr 28.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.

Fungal infections commonly present with myriad symptoms that mimic other clinical entities, notable amongst which is tuberculosis. Besides histoplasmosis and chronic pulmonary aspergillosis, which can mimic TB, this review has identified several other fungal infections which also do. A total of 80 individual cases misdiagnosed as TB are highlighted: aspergillosis ( = 18, 22. Read More

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Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach.

Expert Opin Drug Discov 2022 Jun 9:1-19. Epub 2022 Jun 9.

Department of Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: The three fungal skin neglected tropical diseases (NTD) - mycetoma, chromoblastomycosis and sporotrichosis - currently lack prioritization and support to establish drug discovery programs in search for novel treatment options. This has made the efforts to identify novel drugs for these fragmented skinNTDs.

Areas Covered: To help escalate the discovery of novel drugs to treat these fungal skinNTDs, the authors have prepared an overview of the compounds with activity against fungal skinNTDs by analyzing data from individual drug discovery studies, including those performed on the Medicines for Malaria Venture (MMV) open access boxes. Read More

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Estimated Incidence and Prevalence of Serious Fungal Infections in Morocco.

J Fungi (Basel) 2022 Apr 17;8(4). Epub 2022 Apr 17.

Global Action for Fungal Infections, 1208 Geneva, Switzerland.

Few data are published from Morocco on fungal disease, although numerous case reports attest to a wide range of conditions in the country. Here, we estimate for the first time the incidence and prevalence of serious fungal diseases in the country. Detailed literature searches in English and French were conducted for all serious fungal infections. Read More

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Molecular Diagnosis of Two Major Implantation Mycoses: Chromoblastomycosis and Sporotrichosis.

J Fungi (Basel) 2022 Apr 9;8(4). Epub 2022 Apr 9.

Centre d'Infectiologie Charles Mérieux, Université d'Antananarivo, Antananarivo 101, Madagascar.

Chromoblastomycosis and sporotrichosis are the two main implantation mycoses that are now recognized as fungal neglected tropical diseases (NTDs). Their laboratory diagnosis mainly relies on direct microscopy, histopathology, and identification of the fungus by culture. However, to be appropriately used, these techniques require mycological expertise that is not widely available and may be absent in peripheral health care facilities in endemic areas. Read More

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Fungal Infections of Implantation: More Than Five Years of Cases of Subcutaneous Fungal Infections Seen at the UK Mycology Reference Laboratory.

J Fungi (Basel) 2022 Mar 25;8(4). Epub 2022 Mar 25.

UK Health Security Agency National Mycology Reference Laboratory, Southmead Hospital, Bristol BS10 5NB, UK.

Subcutaneous fungal infections, which typically result from traumatic introduction (implantation) of fungal elements into the skin or underlying tissues, can present as a range of different clinical entities including phaeohyphomycosis, chromoblastomycosis, subcutaneous nodules or masses, and genuine eumycetoma. Here, we mined our laboratory information management system for such infections in humans and domestic animals for the period 2016-2022, including (i) fungal isolates referred for identification and/or susceptibility testing; (ii) infections diagnosed at our laboratory using panfungal PCR approaches on infected tissue; and (iii) organisms cultured in our laboratory from biopsies. In total, 106 cases were retrieved, involving 39 fungal species comprising 26 distinct genera. Read More

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Combination therapy for an elderly patient with chromoblastomycosis caused by : a case report.

Ann Transl Med 2022 Jan;10(2):114

Department of Dermatology, Third Affiliated Hospital of Nantong University, Nantong Third People's Hospital, Nantong, China.

We report the first case of combined treatment using oral drugs, thermotherapy, and carbon dioxide fractional laser for an elderly patient with skin chromoblastomycosis caused by . Chromoblastomycosis is a chronic and refractory granulomatous disease of the skin and subcutaneous tissues caused by a group of dematiaceous fungi, which can cause teratogenesis, disability, and even cancer. One of the subtypes, , is not only limited to the skin and subcutaneous tissues but also affects the central nervous system. Read More

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January 2022

Molecular Characteristics of Regional Chromoblastomycosis in Guangdong, China: Epidemiological, Clinical, Antifungal Susceptibility, and Serum Cytokine Profiles of 45 Cases.

Front Cell Infect Microbiol 2022 18;12:810604. Epub 2022 Feb 18.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Chromoblastomycosis (CBM) is a chronic disease caused by several species of dematiaceous fungi. In this study, a regional collection of 45 CBM cases was conducted in Guangdong, China, a hyper-endemic area of CBM. Epidemiology findings indicated that the mean age of cases was 61. Read More

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In vivo reflectance confocal microscopy, dermoscopy, high-frequency ultrasonography, and histopathology features in a case of chromoblastomycosis.

PLoS Negl Trop Dis 2022 03 3;16(3):e0010226. Epub 2022 Mar 3.

Dermatology Department, Pedro Ernesto University Hospital, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.

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Unusual Presentation of Chromoblastomycosis with a Brief Review of its Atypical Cutaneous Presentations.

Indian Dermatol Online J 2022 Jan-Feb;13(1):140-142. Epub 2022 Jan 24.

Department of Dermatology and Venereology, Government Medical College, Trivandrum, Kerala, India.

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January 2022

Successful treatment of tuberculosis verrucosa cutis with fester as primary manifestation with photodynamic therapy and anti-tubercular drugs.

Photodiagnosis Photodyn Ther 2022 Jun 19;38:102763. Epub 2022 Feb 19.

Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China; Institute of Dermatology, Jiangxi Academy of Clinical Medical Sciences, Nanchang, Jiangxi, China. Electronic address:

Tuberculosis verrucosa cutis (TBVC) is a rare type of cutaneous tuberculosis, which often occurs in the body with good immunity to tuberculosis bacilli. It usually presents as a hyperkeratotic verrucous plaque with polygonal boarders but can mimic or evolved into other dermatosis such as verruca vulgaris, chromoblastomycosis, hyperkeratotic lupus vulgaris, hypertrophic lichen planus, or squamous cell carcinoma, leading to delayed diagnosis. Here, we reported that a 62-year-old patient diagnosed by TBVC with fester as primary manifestation. Read More

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Annular infectious dermatoses.

Clin Dermatol 2021 Dec 31. Epub 2021 Dec 31.

Department of Dermatology and Allergy, Technische Universität München, Munich, Germany. Electronic address:

Annular configuration is conspicuous in the clinical manifestation of many skin diseases and can be helpful for the diagnosis and differential diagnosis. Variations may include arciform, ring-form, annular, circinate, serpiginous, gyrated, polycyclic, targeted or figurate forms, in different colors, sizes, and numbers, with various textures and surfaces. In infectious dermatoses, the annular reactions can be specific or nonspecific, while the underlying mechanisms remain largely unknown. Read More

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December 2021

associated cerebral phaeohyphomycosis in a post-COVID-19 patient: A first case report.

Clin Infect Pract 2022 Jan 6;13:100126. Epub 2021 Dec 6.

Department of Neurosurgery, Directorate General of Khoula Hospital, Muscat, Oman.

Phaeohyphomycosis, previously known as chromoblastomycosis, is a chronic mycosis, usually affecting the skin. It is caused by dematiaceous fungi, which are a group of fungi that produce melanin in their cell walls. Cerebral phaeohyphomycosis occurs as a part of invasive presentation of the fungi, which usually affects immunocompromised patients, but may affect immunocompetent individuals as well. Read More

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January 2022

Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis.

J Immunol Res 2021 1;2021:9742832. Epub 2021 Nov 1.

Dermatology Department, University of São Paulo, Medical School, Clinics Hospital, São Paulo, Brazil.

Chromoblastomycosis (CBM) is a neglected human disease, caused by different species of pigmented dematiaceous fungi that cause subcutaneous infections. This disease has been considered an occupational disease, occurring among people working in the field of agriculture, particularly in low-income countries. In 1914, the first case of CBM was described in Brazil, and although efforts have been made, few scientific and technological advances have been made in this area. Read More

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A Rare Case of Chromoblastomycosis Resembling Keloid in an Indonesian Child.

Cureus 2021 Oct 5;13(10):e18490. Epub 2021 Oct 5.

Dermatology, Suyoto Hospital Centre of Rehabilitation, Ministry of Defense, Jakarta, IDN.

Chromoblastomycosis (CBM) is a rare chronic fungal infection caused by various dematiaceous fungi. This mycosis is mostly found in middle-aged males in tropical and subtropical countries. Only few cases of CBM in children have been reported. Read More

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October 2021

Chromoblastomycosis Due to a Never-before-Seen Dematiaceous Fungus in a Kidney Transplant Patient.

Microorganisms 2021 Oct 13;9(10). Epub 2021 Oct 13.

Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, F-35000 Rennes, France.

Chromoblastomycosis is a neglected fungal infection of the epidermis and subcutaneous tissue that predominates in tropical areas and results from the traumatic inoculation of environmental dematiaceous filamentous fungi. We describe the case of an immunosuppressed patient diagnosed with foot chromoblastomycosis due to an uncommon dematiaceous fungus. A 52-year-old Congolese kidney transplant woman presented with a painful lesion located on the foot. Read More

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October 2021

Neutrophil-suppressive activity over T-cell proliferation and fungal clearance in a murine model of Fonsecaea pedrosoi infection.

Sci Rep 2021 10 12;11(1):20220. Epub 2021 Oct 12.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil.

Neutrophils are essential to control several fungal infections. These cells are commonly known for their pro-inflammatory activities. However, some studies have demonstrated the anti-inflammatory properties of neutrophils during certain infectious diseases, culminating in the inhibition of T cell proliferation. Read More

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October 2021

Chromoblastomycosis in Latin America and the Caribbean: Epidemiology over the past 50 years.

Med Mycol 2021 Dec;60(1)

Mycology/Research Laboratory, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Mato Grosso, CEP 78060-900, Brazil.

Chromoblastomycosis is a chronic disease caused by melanized fungi that mainly affect individuals performing soil-related labor. The objective of this study was to analyze the epidemiological and clinical characteristics of chromoblastomycosis in Latin America and the Caribbean by an extensive literature review. An integrative review was performed of English, French, Portuguese, and Spanish publications in LILACS, SciELO, PubMed, SCOPUS and Web of Science databases covering the period 1969-2019. Read More

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December 2021

Therapeutic management of subcutaneous phaeohyphomycosis and chromoblastomycosis in kidney transplant recipients: a retrospective study of 82 cases in a single center.

Int J Dermatol 2022 Mar 11;61(3):346-351. Epub 2021 Oct 11.

Department of Dermatology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

Background: Melanized fungi are a distinct group of pathogens that cause infections like chromoblastomycosis and phaeohyphomycosis, especially in a state of immunosuppression including solid organ transplant recipients. Guidelines for the treatment of these infections are lacking, and there is no available standard recommendation.

Objective: To evaluate the therapeutic aspects of subcutaneous melanized fungal infections in kidney transplant recipients. Read More

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Cyphellophora laciniata: A new etiological agent of chromoblastomycosis.

J Mycol Med 2022 Mar 9;32(1):101204. Epub 2021 Sep 9.

Departamento de Ecología de Agentes Patógenos. Hospital General "Dr. Manuel Gea González", Tlalpan 14080. Ciudad de México, México. Electronic address:

Chromoblastomycosis is a chronic subcutaneous mycosis caused by traumatic inoculation of dematiaceous fungi especially in tropical and subtropical areas. Cyphellophora genus include melanized fungi reported as etiological agents of skin and nail infections. We report a 60-year-old male from the south of Mexico with a 40-year history of chromoblastomycosis caused by Cyphellophora laciniata. Read More

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Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis.

Am J Trop Med Hyg 2021 09 27;105(6):1696-1697. Epub 2021 Sep 27.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Chromoblastomycosis is a chronic cutaneous fungal infection caused by dematiaceous fungi. It is a therapeutic challenge because of the lack of specific treatments. We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully. Read More

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September 2021

Epidemiology of fungal diseases in Africa: A review of diagnostic drivers.

Curr Med Mycol 2021 Mar;7(1):63-70

Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, University Hospital Ibadan, Ibadan, Nigeria.

Background And Purpose: There has been a significant increase in the burden of fungal diseases in the last few decades which has imposed a global threat to the health of humans, animals, and plants. Epidemiology of fungal diseases is not completely understood in Africa. Most of these diseases are under-reported or not reported at all mainly due to the challenges related to the availability of and access to fungal diagnostics and the lack of human resources in clinical and diagnostic mycology across the continent. Read More

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In-vivo reflectance confocal microscopy in patients with chromoblastomycosis.

Int J Infect Dis 2021 Dec 20;113:297-299. Epub 2021 Sep 20.

Department of Tropical Medicine and Dermatology, Institute of Tropical Pathology, and Public Health, Federal University of Goiás, Goiás, Brazil.

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December 2021

Chromoblastomycosis evolving to sarcomatoid squamous cell carcinoma: A case report.

Dermatol Reports 2021 Aug 5;13(2):9009. Epub 2021 Aug 5.

Institute of Biosciences, São Paulo State University (UNESP), São Vicente.

Chromoblastomycosis (CMB) is a cutaneous fungal infection caused by dematiaceous fungi. According to the World Health Organization CMB has been elected as a tropical disease, and it is prevalent in tropical and subtropical regions. The lower extremities are the most affected areas, and the lesions progress with erythema, papules, nodules, verrucose plates and/or ulcerations. Read More

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A Case of Trauma-Induced Eumycetoma in a Renal Transplant Recipient.

Trop Med Infect Dis 2021 Aug 3;6(3). Epub 2021 Aug 3.

Infectious Diseases Department, St Vincent's Hospital, Melbourne, VIC 3065, Australia.

Mycetoma is a chronic, granulomatous, subcutaneous infection caused by several species of fungi and soil-inhabiting bacteria, and is divided into eumycetoma and actinomycetoma, respectively. Endemicity is described with worldwide distribution within the "mycetoma belt"; however, the global burden is ill-defined. Mycetoma is rare in Australia, with only a few published case reports. Read More

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Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time.

J Dermatol 2021 Oct 18;48(10):1612-1615. Epub 2021 Aug 18.

São Paulo State University (UNESP), Institute of Biosciences, São Vicente, Brazil.

Chromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. Read More

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October 2021

The global burden of chromoblastomycosis.

PLoS Negl Trop Dis 2021 08 12;15(8):e0009611. Epub 2021 Aug 12.

Special Mycology Laboratory-LEMI, Division of Infectious Diseases, Federal University of São Paulo, São Paulo, SP, Brazil.

Background: Chromoblastomycosis (CBM), represents one of the primary implantation mycoses caused by melanized fungi widely found in nature. It is characterized as a Neglected Tropical Disease (NTD) and mainly affects populations living in poverty with significant morbidity, including stigma and discrimination.

Methods And Findings: In order to estimate the global burden of CBM, we retrospectively reviewed the published literature from 1914 to 2020. Read More

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