1,10-Phenanthroline-5,6-Dione-Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa.
- Marcela Queiroz Granato,
- Diego de Souza Gonçalves,
- Sergio Henrique Seabra,
- Malachy McCann,
- Michael Devereux,
- André Luis Souza Dos Santos,
- Lucimar Ferreira Kneipp
Front Microbiol 2017 30;8:76. Epub 2017 Jan 30.
Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz Rio de Janeiro, Brazil.
Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. Read More