1,159 results match your criteria Chromoblastomycosis


Vitiligo-like depigmentation after chromoblastomycosis: a kind of postinflammatory depigmentation due to fungal infection.

Mycopathologia 2020 Jun 19. Epub 2020 Jun 19.

Department of Dermatology, Affiliated Hangzhou Third Hospital, Anhui Medical University, West Lake Rd 38, Hangzhou, 310009, People's Republic of China.

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http://dx.doi.org/10.1007/s11046-020-00468-3DOI Listing

Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis.

PLoS Negl Trop Dis 2020 Jun 15;14(6):e0008386. Epub 2020 Jun 15.

Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.

Chromoblastomycosis (CBM) is a chronic worldwide subcutaneous mycosis, caused by several dimorphic, pigmented dematiaceous fungi. It is difficult to treat patients with the disease, mainly because of its recalcitrant nature. The correct activation of host immune response is critical to avoid fungal persistence in the tissue and disease chronification. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316354PMC

A case of mycetoma-like chromoblastomycosis in Qatar.

IDCases 2020 30;21:e00853. Epub 2020 May 30.

Department of Infectious Diseases, Qatar.

Chromoblastomycosis is one of the neglected tropical mycoses associated with chronic infection of the skin and subcutaneous tissues. We report a case of 49-year-old patient originally from India presented with a mycetoma-like lesion in his right foot which was slowly progressing over three-year period. The diagnosis of chromoblastomycosis was confirmed following surgical excision and identification of the unique histological pathology of muriform bodies. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283144PMC

Muriform Cells Can Reproduce by Dividing in an Athymic Murine Model of Chromoblastomycosis due to .

Am J Trop Med Hyg 2020 Jun 8. Epub 2020 Jun 8.

Department of Dermatology, Center for Infectious Skin Diseases, No.1 Hospital of Wuhan, Wuhan, China.

Transformation of into muriform cells enhances the resistance against phagocytosis and elimination by host immune cells, and links to the chronicity of chromoblastomycosis. Here, we aim to determine whether the muriform cells can reproduce in tissue without reverse transformation into hyphal form by using an experimental nu/nu-BALB/c mouse model of chromoblastomycosis due to . During the whole 81-day observation period, most of the hyphal inocula had transformed into muriform cells at 75 days postinoculation and maintained as this parasitic morphology till 81 days postinoculation simultaneously with increased fungal loads in tissue and the worsening of footpad lesion. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0465DOI Listing
June 2020
2.699 Impact Factor

Mycetoma and Chromoblastomycosis: Perspective for Diagnosis Improvement Using Biomarkers.

Molecules 2020 Jun 2;25(11). Epub 2020 Jun 2.

Malaria Research Unit, University Lyon, ICBMS, UMR 5246 CNRS INSA CPE, Campus Lyon-Tech La Doua, F-69100 Lyon, France.

Background: Mycetoma and chromoblastomycosis are both chronic subcutaneous infectious diseases that pose an obstacle to socioeconomic development. Besides the therapeutic issue, the diagnosis of most neglected tropical diseases (NTD) is challenging. Confirmation using direct microscopy and culture, recognized as WHO essential diagnostic tests, are limited to specialized facilities. Read More

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http://dx.doi.org/10.3390/molecules25112594DOI Listing

Case for diagnosis. Pruritic erythematosquamous lesion in the auricle.

An Bras Dermatol 2020 Jul - Aug;95(4):521-523. Epub 2020 May 11.

Department of Tropical Dermatology, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Chromoblastomycosis is a subcutaneous mycosis with chronic evolution that mainly affects the lower limbs and, less frequently, the auricles. Clinically, it presents with papillary verrucous, nodular, and/or tumoral lesions, whether isolated or infiltrated, forming plaques and, sometimes, atrophic in some areas. Histopathologically, it is characterized by a dermal granulomatous inflammatory infiltrate, and the diagnosis can be confirmed by the presence of fumagoid bodies in anatomopathological or direct mycological exams. Read More

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http://dx.doi.org/10.1016/j.abd.2019.11.011DOI Listing

Chromoblastomycosis caused by Cladophialophora carrionii.

Authors:
Linwei Wei Jin Yu

Infection 2020 May 25. Epub 2020 May 25.

Department of Dermatology and Venereology, Peking University First Hospital, 1st Xi'an Men Street, Xicheng District, Beijing, 100034, China.

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http://dx.doi.org/10.1007/s15010-020-01437-0DOI Listing

Endemic Chromoblastomycosis Caused Predominantly by Fonsecaea nubica, Madagascar.

Emerg Infect Dis 2020 Jun;26(6):1201-1211

Chromoblastomycosis is an implantation fungal infection. Twenty years ago, Madagascar was recognized as the leading focus of this disease. We recruited patients in Madagascar who had chronic subcutaneous lesions suggestive of dermatomycosis during March 2013-June 2017. Read More

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http://dx.doi.org/10.3201/eid2606.191498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258462PMC

Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work.

J Dermatol 2020 Jul 15;47(7):787-791. Epub 2020 May 15.

Department of Dermatology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.

Porokeratoma is a recently described solitary or multiple tumor-like acanthoma, sharing the histological feature of cornoid lamellae with porokeratosis. Whether porokeratoma is a variant of porokeratosis is controversial. We report a rare case of a 53-year-old Chinese woman who presented with multiple, symmetrical, hemispherical and verrucous plaques on her lower extremities that had been present for 20 years. Read More

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http://dx.doi.org/10.1111/1346-8138.15376DOI Listing

A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis.

PLoS One 2020 13;15(5):e0229630. Epub 2020 May 13.

Mycology Laboratory at the Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.

Chromoblastomycosis (CBM) is a chronic subcutaneous mycosis caused by traumatic implantation of many species of black fungi. Due to the refractoriness of some cases and common recurrence of CBM, a more effective and less time-consuming treatment is mandatory. The aim of this study was to identify compounds with in vitro antifungal activity in the Pathogen Box® compound collection against different CBM agents. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219733PMC

Effect of Fonsecaea monophora on the Polarization of THP-1 Cells to Macrophages.

Mycopathologia 2020 Jun 10;185(3):467-476. Epub 2020 Apr 10.

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Chromoblastomycosis is a chronic, progressive fungal disease of the skin and subcutaneous tissue caused by a unique group of dematiaceous fungi. Fonsecaea monophora, a new species distinct from Fonsecaea pedrosoi strains, is the main pathogen responsible for chromoblastomycosis in south China. Macrophages can be polarized into two categories: classically activated and alternatively activated. Read More

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http://dx.doi.org/10.1007/s11046-020-00444-xDOI Listing

Deep fungal infections diagnosed by histology in Uganda: a 70-year retrospective study.

Med Mycol 2020 Apr 3. Epub 2020 Apr 3.

Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Fungal infections cause substantial morbidity and mortality. However, the burden of deep fungal infections is not well described in Uganda. We aimed to estimate the burden and etiology of histologically diagnosed deep fungal infections in Uganda. Read More

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http://dx.doi.org/10.1093/mmy/myaa018DOI Listing
April 2020
2.335 Impact Factor

[Management of chromoblastomycosis, a challenge for limited-resource countries such as Madagascar].

Ann Dermatol Venereol 2020 May 24;147(5):377-382. Epub 2020 Mar 24.

USFR dermatologie, hôpital universitaire Joseph Raseta Befelatanana Antananarivo, Antananarivo, Madagascar.

Introduction: Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissue caused by dematiaceous fungi. CBM lesions are recalcitrant and extremely difficult to eradicate. We report three cases of CBM with difficulties in therapeutic management. Read More

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http://dx.doi.org/10.1016/j.annder.2020.01.018DOI Listing

Selective isolation of agents of chromoblastomycosis from insect-associated environmental sources.

Fungal Biol 2020 Mar - Apr;124(3-4):194-204. Epub 2020 Feb 12.

Graduate Program in Microbiology, Parasitology and Pathology, Federal University of Paraná, Curitiba, Brazil. Electronic address:

Chromoblastomycosis is a neglected disease characterized by cutaneous, subcutaneous or disseminated lesions. It is considered an occupational infectious disease that affects mostly rural workers exposed to contaminated soil and vegetal matter. Lesions mostly arise after a traumatic inoculation of herpotrichiellaceous fungi from the Chaetothyriales order. Read More

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http://dx.doi.org/10.1016/j.funbio.2020.02.002DOI Listing
February 2020

Cerebral Chromoblastomycosis due to Cladosporium Trichoides (Bantianum) - Part I (A Review and Case Report).

Neurol India 2020 Jan-Feb;68(1):11-14

Surgical Registrars, Department of Neurosurgery, K.E.M. Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/0028-3886.279712DOI Listing

A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine.

Dermatol Ther (Heidelb) 2020 Apr 21;10(2):321-327. Epub 2020 Feb 21.

Department of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510182, China.

Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal culture and gene sequencing. This patient was successfully treated with a regimen of oral itraconazole (ITZ) and terbinafine lasting 7 months. Read More

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http://dx.doi.org/10.1007/s13555-020-00358-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090106PMC

A Novel Species Associated With Disseminated Granulomatous Inflammation in a Captive Eastern Hellbender ().

Front Vet Sci 2020 31;7:25. Epub 2020 Jan 31.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.

The genus is composed of ubiquitous, pigmented, saprotrophic fungi and includes both terrestrial and waterborne species. Though species are generally considered opportunistic pathogens, exophialosis can be an important cause of morbidity and mortality in aquatic and semi-aquatic species. Over a 6-year period, a captive 32-year-old male eastern hellbender (), was treated for recurring, slow growing, ventral midline cutaneous masses. Read More

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http://dx.doi.org/10.3389/fvets.2020.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004953PMC
January 2020

Aspartic peptidase of as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction.

J Enzyme Inhib Med Chem 2020 Dec;35(1):629-638

Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos (LTBBF), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

causes several fungal human diseases, mainly chromoblastomycosis, which is extremely difficult to treat. Several studies have shown that human immunodeficiency virus peptidase inhibitors (HIV-PIs) are attractive candidates for antifungal therapies. This work focused on studying the action of HIV-PIs on peptidase activity secreted by and their effects on fungal proliferation and macrophage interaction. Read More

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http://dx.doi.org/10.1080/14756366.2020.1724994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034032PMC
December 2020

Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11c Cells in Regional Lymph Nodes During Experimental Chromoblastomycosis.

Mycopathologia 2020 Apr 1;185(2):245-256. Epub 2020 Feb 1.

Laboratory of Mycology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Scienses, Universidade de Sao Paulo, São Paulo, Brazil.

The chromoblastomycosis is a subcutaneous mycosis with a high morbidity rate, Fonsecaea pedrosoi being the largest etiologic agent of this mycosis, usually confined to the skin and subcutaneous tissues. Rarely people get the cure, because the therapies shown to be deficient and few studies report the host-parasite relationship. Dendritic cells (DCs) are specialized in presenting antigens to naïve T lymphocytes inducing primary immune responses. Read More

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http://dx.doi.org/10.1007/s11046-020-00429-wDOI Listing

Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod.

J Dermatol 2020 Apr 21;47(4):409-412. Epub 2020 Jan 21.

Institute of Biosciences, São Paulo State University (UNESP), São Vicente, Brazil.

Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered complex and ineffective due to the high rate of relapses. Thus, new strategies are needed to manage CBM; in this regard, the present work reports the evolution of lesions in patients successfully treated with imiquimod. Read More

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http://dx.doi.org/10.1111/1346-8138.15225DOI Listing
April 2020
2.354 Impact Factor

An optimized Agrobacterium tumefaciens-mediated transformation system for random insertional mutagenesis in Fonsecaea monophora.

J Microbiol Methods 2020 Mar 8;170:105838. Epub 2020 Jan 8.

Department of Dermatology and Venerology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Chromoblastomycosis (CBM) is a chronic cutaneous or subcutaneous mycosis that is prevalent worldwide. Though CBM tends not to be fatal, it is difficult to treat and complications can include chronic, marked lesions, lymphatic damage, and neoplastic transformation. Fonsecaea monophora, as a new species segregated from Fonsecaea pedrosoi, is the predominant causative pathogen of CBM in southern China. Read More

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http://dx.doi.org/10.1016/j.mimet.2020.105838DOI Listing

Dermoscopy of Chromoblastomycosis.

Indian Dermatol Online J 2019 Nov-Dec;10(6):759-760. Epub 2019 Nov 1.

Department of Pathology, Himalayan Institue of Medical Sciences, Dehradun, Uttarakhand, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_213_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859775PMC
November 2019

Chromoblastomycosis caused by Rhinocladiella aquaspersa: first case report in Guatemala.

An Bras Dermatol 2019 Sep - Oct;94(5):574-577. Epub 2019 Sep 30.

Unit of Investigation, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca, Mexico. Electronic address:

The authors report a case of 40-year-old male patient with a five-year history of chromoblastomycosis on his right leg. Diagnosis was performed by direct 40% KOH exam of skin scales, culture with micro- and macromorphologic analysis, and genotypic characterization (sequencing of a fragment of the ITS region and phylogenetic analysis) of the isolated fungus. Rhinocladiella aquaspersa was identified as the etiological agent. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857580PMC
December 2019

5-aminolevulinic acid-based photodynamic therapy associated with Itraconazole successfully treated a case of chromoblastomycosis.

Photodiagnosis Photodyn Ther 2020 Mar 2;29:101589. Epub 2019 Nov 2.

Department of Dermatology, Daping Hospital, The Army Medical University, Chongqing 400042, China. Electronic address:

Chromoblastomycosis (CBM) is a prevalent implantation fungal infection. Patients with CBM show chronic granulomatous hyperplasia with ulcers and exudation. It may cause incapacity for labor in some severe clinical forms and it is often refractory to antifungal therapies. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.101589DOI Listing
March 2020
1 Read

Photodynamic therapy combined with antifungal drugs against chromoblastomycosis and the effect of ALA-PDT on Fonsecaea in vitro.

PLoS Negl Trop Dis 2019 10 31;13(10):e0007849. Epub 2019 Oct 31.

Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.

Background: Chromoblastomycosis is a chronic skin and subcutaneous fungal infection caused by dematiaceous fungi and is associated with low cure and high relapse rates. In southern China, Fonsecaea monophora and Fonsecaea pedrosoi are the main causative agents.

Principal Findings: We treated 5 refractory and complex cases of chromoblastomycosis with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with oral antifungal drugs. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850556PMC
October 2019

Chromoblastomycosis: a neglected disease.

Rev Assoc Med Bras (1992) 2019;65(9):1130-1132. Epub 2019 Oct 10.

. Faculdade de Medicina, Universidade Federal de Goiás (UFG), Goiânia, Goiás, GO, Brasil.

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http://dx.doi.org/10.1590/1806-9282.65.9.1130DOI Listing
February 2020
1 Read

The Diagnosis of Fungal Neglected Tropical Diseases (Fungal NTDs) and the Role of Investigation and Laboratory Tests: An Expert Consensus Report.

Trop Med Infect Dis 2019 Sep 24;4(4). Epub 2019 Sep 24.

Drugs for Neglected Disease Initiative, 1202 Geneva, Switzerland.

The diagnosis of fungal Neglected Tropical Diseases (NTD) is primarily based on initial visual recognition of a suspected case followed by confirmatory laboratory testing, which is often limited to specialized facilities. Although molecular and serodiagnostic tools have advanced, a substantial gap remains between the desirable and the practical in endemic settings. To explore this issue further, we conducted a survey of subject matter experts on the optimal diagnostic methods sufficient to initiate treatment in well-equipped versus basic healthcare settings, as well as optimal sampling methods, for three fungal NTDs: mycetoma, chromoblastomycosis, and sporotrichosis. Read More

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http://dx.doi.org/10.3390/tropicalmed4040122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958312PMC
September 2019
5 Reads

A Rare Case of Chromoblastomycosis in a 12-year-old boy.

J Pak Med Assoc 2019 Sep;69(9):1390-1393

Final Year MBBS, Khyber Medical College Peshawar, Pakistan.

Chromoblastomycosis is a chronic fungal infection of the subcutaneous tissue. The infection usually results from a traumatic injury and inoculation of the microorganism by a specific group of dematiaceous fungi, resulting in the formation of verrucous plaques. The fungi produce sclerotic or medlar bodies (also called muriform bodies or sclerotic cells) seen on direct microscopic examination of skin smears. Read More

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September 2019
4 Reads
0.403 Impact Factor

Dermoscopic Characterization in Pigmented Skin: Interpret "Pigmented" Structures Carefully.

Dermatol Pract Concept 2019 Jul 31;9(3):211-213. Epub 2019 Jul 31.

Department of Dermatology, Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

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http://dx.doi.org/10.5826/dpc.0903a08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659607PMC
July 2019
4 Reads

Chromoblastomycosis with a sporotrichoid distribution.

Indian J Dermatol Venereol Leprol 2019 Sep-Oct;85(5):506-508

Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_16_19DOI Listing
February 2020
3 Reads

Chromoblastomycosis in the Amazon region, Brazil, caused by Fonsecaea pedrosoi, Fonsecaea nubica, and Rhinocladiella similis: Clinicopathology, susceptibility, and molecular identification.

Med Mycol 2020 Feb;58(2):172-180

Department of Medicine, Faculty of São Lucas, Rondônia, Brazil.

Chromoblastomycosis is a chronic subcutaneous disease caused by human contact with melanized fungi occurring mainly in tropical and subtropical zones worldwide. This study assessed 12 patients with chromoblastomycosis from Rondônia, Brazil, Amazon region. In sum, 83. Read More

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http://dx.doi.org/10.1093/mmy/myz034DOI Listing
February 2020
5 Reads

Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease.

Med Mycol 2020 Jan;58(1):66-70

Department of Dermatology, Peking University First Hospital; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses; Research Center for Medical Mycology, Peking University, Beijing 100034, China.

Common histopathologic techniques are used to diagnose fungal infections, but the diagnostic identification of mycoses in tissue specimens is often difficult, particularly when fungi rarely occur in a specimen. The aim of this study was to evaluate the application of fluorescein-labeled chitinase staining to formalin-fixed and paraffin-embedded (FFPE) tissues. We studied 79 archival FFPE tissues from patients diagnosed with fungal disease, including 38 cases of sporotrichosis and 41 cases of other fungal infections. Read More

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http://dx.doi.org/10.1093/mmy/myz035DOI Listing
January 2020
6 Reads

New Molecular Markers Distinguishing Fonsecaea Agents of Chromoblastomycosis.

Mycopathologia 2019 Aug 17;184(4):493-504. Epub 2019 Jul 17.

Microbiology, Parasitology and Pathology Post-Graduation Program, Department of Pathology, Federal University of Paraná, Curitiba, Brazil.

The species belonging to the genus Fonsecaea are the main causative agents of chromoblastomycosis. The invasive potential of Fonsecaea differs significantly among its various sibling species. Moreover, the lack of clarity on the virulence and availability of precise markers to distinguish and detect Fonsecaea species is attributed to the different ways of dissemination and pathogenicity. Read More

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http://dx.doi.org/10.1007/s11046-019-00359-2DOI Listing
August 2019
4 Reads

[Long-pulsed 1064 nm Nd: YAG laser combined with terbinafine against chromoblastomycosis caused by and the effect of laser therapy in a Wistar rat model].

Nan Fang Yi Ke Da Xue Xue Bao 2019 Jun;39(6):712-717

Department of Dermatology and Venerology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

We report a case of chromoblastomycosis caused by , which was successfully treated by long-pulsed 1064 nm Nd: YAG laser combined with terbinafine. A 60-year-old man was admitted for the presence of a 30 mm×40 mm erythematous plaque on the dorsum of his right hand for about 10 months without any subjective symptoms. Both microscopic examination and tissue biopsy of the lesion showed characteristic sclerotic bodies of chromoblastomycosis. Read More

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http://dx.doi.org/10.12122/j.issn.1673-4254.2019.06.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743912PMC
June 2019
12 Reads

Mixed secondary bacterial infection is associated with severe lesions of chromoblastomycosis in a neglected population from Brazil.

Diagn Microbiol Infect Dis 2019 Oct 31;95(2):201-207. Epub 2019 May 31.

Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil. Electronic address:

Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by melanotic fungi, affecting mainly rural workers in tropical and subtropical regions. Secondary bacterial infections (SBIs) in CBM lesions bring complications to the disease, but little is known about the agents involved. Fungal and bacterial identification and epidemiological profile of 50 patients with CBM were analyzed in this study. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.05.018DOI Listing
October 2019
9 Reads

Synergistic effect of terbinafine and amphotericin B in killing Fonsecaea nubica in vitro and in vivo.

Rev Inst Med Trop Sao Paulo 2019 Jun 19;61:e31. Epub 2019 Jun 19.

Yat-sen University, Sun Yat-sen Memorial Hospital, Department of Dermatology and Venereology, Guangzhou, China.

Chromoblastomycosis is a chronic fungal infection. Itraconazole and terbinafine are the most recommended antifungal drugs for chromoblastomycosis, while amphotericin B is not usually recommended. A patient with chromoblastomycosis in our hospital showed poor clinical responses to itraconazole and terbinafine. Read More

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http://dx.doi.org/10.1590/S1678-9946201961031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592013PMC
June 2019
5 Reads

Case report: Fever- pneumonia- lymphadenectasis- osteolytic- subcutaneous nodule: Disseminated chromoblastomycosis caused by phialophora.

J Infect Chemother 2019 Dec 20;25(12):1031-1036. Epub 2019 Jun 20.

Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous fungal infection caused by certain dematiaceous fungi (usually Fonsecaea, Phialophora, or Cladophialophora). Histologically, CBM is characterized by the presence of medlar bodies. However, the diagnosis is difficult because of the rarity of these pathognomonic presentations and the wide variety of presentations. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.05.002DOI Listing
December 2019
13 Reads

Endemic Mycoses in Children.

Pediatr Infect Dis J 2019 06;38(6S Suppl 1):S52-S59

From the Infectious Diseases Unit, The Royal Children's Hospital Melbourne.

The endemic mycoses are a group of infections caused by fungi with a distinct geographic distribution, defined by climatic and environmental conditions. The systemic endemic mycoses, namely histoplasmosis, blastomycosis, talaromycosis, coccidioidomycosis and paracoccidioidomycosis, occur after the inhalation of fungal spores. The cutaneous endemic mycoses, including sporotrichosis, mycetoma, entomophthoramycosis and chromoblastomycosis, enter the host via traumatic inoculation of the skin. Read More

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http://dx.doi.org/10.1097/INF.0000000000002324DOI Listing
June 2019
23 Reads

Lymphocutaneous Sporotrichosis of Face with Verrucous Lesions: A Case Report.

Indian Dermatol Online J 2019 May-Jun;10(3):303-306

Department of Dermatology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Sporotrichosis is a cutaneous mycosis caused by a dimorphic fungus, species complex clinically presenting as lymphocutaneous, fixed, or disseminated forms. A typical lesion is an erythematous papule, noduloulcerative lesion usually occurring at the site of penetrating trauma, mostly on the extremities. Verrucous lesion is an unusual presentation of sporotrichosis which can mimic the verrucous lesions seen in chromoblastomycosis, tuberculosis verruca cutis/lupus vulgaris (TBVC/LV), cutaneous leishmaniasis, and blastomycosis leading to diagnostic dilemma. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_272_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536070PMC
June 2019
14 Reads

Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 04 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
32 Reads

Elbow Malformation with Osteoarthritis and Bone Destruction Caused by Chromoblastomycosis.

Mycopathologia 2019 06 6;184(3):459-460. Epub 2019 Apr 6.

Department of Dermatoverenology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.

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http://dx.doi.org/10.1007/s11046-019-00333-yDOI Listing
June 2019
9 Reads

: Key issues of an opportunistic fungal pathogen.

Virulence 2019 12 3;10(1):984-998. Epub 2019 Apr 3.

Institute of Medical Microbiology, Center of Excellence in Clinical and Laboratory Mycology and Clinical Studies, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

The black yeast is an opportunistic pathogen, causing phaeohyphomycosis in immunosuppressed patients, chromoblastomycosis and fatal infections of the central nervous system in otherwise healthy Asian patients. In addition, it is also regularly isolated from respiratory samples from cystic fibrosis patients, with rates varying between 1% and 19%.Melanin, as part of the cell wall of black yeasts, is one major factor known contributing to the pathogenicity of and increased resistance against host defense and anti-infective therapeutics. Read More

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http://dx.doi.org/10.1080/21505594.2019.1596504DOI Listing
December 2019
17 Reads

Cutaneous Chromoblastomycosis: A Prototypal Case.

J Cutan Med Surg 2019 Jan/Feb;23(1):98

2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1177/1203475418789029DOI Listing
November 2019
9 Reads
0.714 Impact Factor

Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia.

Photodiagnosis Photodyn Ther 2019 Jun 12;26:13-14. Epub 2019 Feb 12.

Department of Dermatology, Nanfang Hospital, Southern Medical University, 1838 North Avenue, Guangzhou 510515, China. Electronic address:

Chromoblastomycosis is a long-term fungal infection of the skin and subcutaneous tissue, usually presenting as partial hypertrophic and warty plaques. Effective treatment is necessary to control the development of lesions, especially in patients with associated diseases. But till now, the treatment is still a challenge. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.013DOI Listing
June 2019
11 Reads
2.014 Impact Factor

Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella.

Med Mycol 2019 Nov;57(8):1018-1023

Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. Read More

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http://dx.doi.org/10.1093/mmy/myz007DOI Listing
November 2019
6 Reads

[Chromoblastomycosis in Mexico. A forgotten disease].

Salud Publica Mex 2019 Ene-Feb;61(1)

Departamento de Ciencias Básicas, Vicerrectoría de Ciencias de la Salud, Universidad de Monterrey. San Pedro Garza García, Nuevo León, México.

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http://dx.doi.org/10.21149/9459DOI Listing
November 2019
12 Reads

Study of tissue inflammatory response in different mice strains infected by dematiaceous fungi Fonsecaea pedrosoi.

An Bras Dermatol 2019 Jan-Feb;94(1):29-36

Department of Dermatology, Universidade Federal de São Paulo, São Paulo (SP), Brazil.

Background: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exemple. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360977PMC
February 2019
26 Reads

A Case of Chromoblastomycosis Caused by Fonsecaea Pedrosoi and Investigation of the Pathogenic Fungi.

Mycopathologia 2019 Apr 30;184(2):349-352. Epub 2019 Jan 30.

Department of Dermatovenerology, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510120, Guangdong Province, China.

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http://link.springer.com/10.1007/s11046-019-0319-4
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http://dx.doi.org/10.1007/s11046-019-0319-4DOI Listing
April 2019
53 Reads

A fatal case of Exophiala dermatitidis disseminated infection in an allogenic hematopoietic stem cell transplant recipient during micafungin therapy.

J Infect Chemother 2019 Jun 22;25(6):463-466. Epub 2019 Jan 22.

Division of Infection Control and Prevention, Osaka University Hospital, Osaka, Japan.

Exophiala dermatitidis is a dematiaceous fungus that is increasingly becoming the cause of fungal infection in immunocompromised patients. However, the risk factors and optimal treatment modality for E. dermatitidis infection are unknown to date. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.009DOI Listing
June 2019
11 Reads

Transcriptional profiling of macrophages infected with Fonsecaea monophora.

Mycoses 2019 Apr 20;62(4):374-383. Epub 2019 Feb 20.

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Fonsecaea monophora is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. Read More

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http://dx.doi.org/10.1111/myc.12894DOI Listing
April 2019
11 Reads