1,118 results match your criteria Chromoblastomycosis


Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

Elbow Malformation with Osteoarthritis and Bone Destruction Caused by Chromoblastomycosis.

Mycopathologia 2019 Apr 6. Epub 2019 Apr 6.

Department of Dermatoverenology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.

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http://dx.doi.org/10.1007/s11046-019-00333-yDOI Listing
April 2019
1 Read

Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen.

Virulence 2019 Mar 19:1-15. Epub 2019 Mar 19.

a Institute of Medical Microbiology, Center of Excellence in Clinical and Laboratory Mycology and Clinical Studies , University Hospital Essen, University of Duisburg-Essen , Essen , Germany.

The black yeast Exophiala dermatitidis is an opportunistic pathogen, causing phaeohyphomycosis in immunosuppressed patients, chromoblastomycosis and fatal infections of the central nervous system in otherwise healthy Asian patients. In addition, it is also regularly isolated from respiratory samples from cystic fibrosis patients, with rates varying between 1% and 19%. Melanin, as part of the cell wall of black yeasts, is one major factor known contributing to the pathogenicity of E. Read More

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http://dx.doi.org/10.1080/21505594.2019.1596504DOI Listing
March 2019
1 Read

Cutaneous Chromoblastomycosis: A Prototypal Case.

J Cutan Med Surg 2019 Jan/Feb;23(1):98

2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1177/1203475418789029DOI Listing
February 2019
1 Read
0.714 Impact Factor

Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Department of Dermatology, Nanfang Hospital, Southern Medical University, 1838 North Avenue, Guangzhou 510515, China. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.013DOI Listing
February 2019
2 Reads
2.014 Impact Factor

Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella.

Med Mycol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. Read More

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http://dx.doi.org/10.1093/mmy/myz007DOI Listing
February 2019

[Chromoblastomycosis in Mexico. A forgotten disease].

Salud Publica Mex 2019 Ene-Feb;61(1)

Departamento de Ciencias Básicas, Vicerrectoría de Ciencias de la Salud, Universidad de Monterrey. San Pedro Garza García, Nuevo León, México.

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http://dx.doi.org/10.21149/9459DOI Listing
February 2019

Study of tissue inflammatory response in different mice strains infected by dematiaceous fungi Fonsecaea pedrosoi.

An Bras Dermatol 2019 Jan-Feb;94(1):29-36

Department of Dermatology, Universidade Federal de São Paulo, São Paulo (SP), Brazil.

Background: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exemple. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360977PMC
February 2019
2 Reads

A Case of Chromoblastomycosis Caused by Fonsecaea Pedrosoi and Investigation of the Pathogenic Fungi.

Mycopathologia 2019 Apr 30;184(2):349-352. Epub 2019 Jan 30.

Department of Dermatovenerology, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510120, Guangdong Province, China.

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http://link.springer.com/10.1007/s11046-019-0319-4
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http://dx.doi.org/10.1007/s11046-019-0319-4DOI Listing
April 2019
11 Reads

A fatal case of Exophiala dermatitidis disseminated infection in an allogenic hematopoietic stem cell transplant recipient during micafungin therapy.

J Infect Chemother 2019 Jan 22. Epub 2019 Jan 22.

Division of Infection Control and Prevention, Osaka University Hospital, Osaka, Japan.

Exophiala dermatitidis is a dematiaceous fungus that is increasingly becoming the cause of fungal infection in immunocompromised patients. However, the risk factors and optimal treatment modality for E. dermatitidis infection are unknown to date. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.009DOI Listing
January 2019
2 Reads

Transcriptional profiling of macrophages infected with Fonsecaea monophora.

Mycoses 2019 Apr 20;62(4):374-383. Epub 2019 Feb 20.

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Fonsecaea monophora is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. Read More

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http://dx.doi.org/10.1111/myc.12894DOI Listing
April 2019
3 Reads

Chromoblastomycosis Caused by Phialophora verrucosa in a Costa Rican Child with Skin Sequelae due to Snake Bite.

Cureus 2018 Nov 12;10(11):e3574. Epub 2018 Nov 12.

Pediatrics, Hospital Nacional De Niños "dr. Carlos Sáenz Herrera" Caja Costarricense Del Seguro Social, San Jose, CRI.

Chromoblastomycosis is an implantation mycosis occurring among adults working in farms or with soil in tropical and subtropical areas worldwide. is the most important agent in the tropical areas, while , although not a predominant agent, is found in the lowlands under the same conditions as the  species. We present the case of a 10-year-old aboriginal boy, belonging to a soil worker family, with a history of extensive leg lesions and lymphedema secondary to a snake bite five years earlier. Read More

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https://www.cureus.com/articles/15475-chromoblastomycosis-ca
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http://dx.doi.org/10.7759/cureus.3574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333267PMC
November 2018
12 Reads

Dermoscopic features in nodular chromoblastomycosis.

Int J Dermatol 2019 May 18;58(5):e107-e109. Epub 2018 Dec 18.

Department of Pathology, Government Medical College, Trivandrum, Kerala, India.

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http://dx.doi.org/10.1111/ijd.14344DOI Listing
May 2019
2 Reads

Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review.

Mycopathologia 2019 Feb 13;184(1):97-105. Epub 2018 Dec 13.

Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Chromoblastomycosis is found worldwide with higher incidence in tropical and subtropical regions. Fonsecaea spp. is one of the major causative agents of this disease. Read More

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http://dx.doi.org/10.1007/s11046-018-0307-0DOI Listing
February 2019
1 Read

: A new agent of chromoblastomycosis.

Med Mycol Case Rep 2019 Mar 25;23:31-33. Epub 2018 Oct 25.

Laboratorio de Micologia y Fitopatologia (LAMFU), Departamento de Ciencias Biológicas, Facultad de ciencias, Universidad de los Andes, Bogota 111711, Colombia.

Chromoblastomycosis is a chronic cutaneous and subcutaneous mycosis, is caused by dematiaceous fungi, the most frequently implicated are and We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263014PMC
March 2019
2 Reads

Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study.

Indian J Dermatol 2018 Nov-Dec;63(6):496-501

Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.

Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More

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http://dx.doi.org/10.4103/ijd.IJD_16_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233045PMC
December 2018
6 Reads

Erythematous verrucous plaque on the hand.

Cutis 2018 Oct;102(4):223;230;231

Department of Dermatology, Hospital Sultanah Aminah Johor Bahru, Johor, Malaysia.

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October 2018
1 Read

[Fonsecaea pedrosoi-induced chromoblastomycosis: about a case].

Pan Afr Med J 2018 28;30:187. Epub 2018 Jun 28.

Service de Dermatologie et de Vénéréologie, CHU Ibn Rochd, Casablanca, Maroc.

We report the case of a 13-year old female patient from rural areas presenting with papulonodular lesion of 4/3cm in the lower third of the right leg, evolving over the last two years. Skin biopsy showed papillomatous hyperplasia with neutrophilic microabscess and spores. Direct mycological examination showed fumagoid bodies and Fonsecaea pedrosoi was isolated from culture. Read More

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http://www.panafrican-med-journal.com/content/article/30/187
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http://dx.doi.org/10.11604/pamj.2018.30.187.5326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235512PMC
December 2018
12 Reads

A Model for Trans-Kingdom Pathogenicity in Agents of Human Chromoblastomycosis.

Front Microbiol 2018 9;9:2211. Epub 2018 Oct 9.

Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, Brazil.

The fungal genus comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The present study aimed to evaluate a model of infection in plant and animal hosts to understand the parameters of trans-kingdom pathogenicity. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02211
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http://dx.doi.org/10.3389/fmicb.2018.02211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189323PMC
October 2018
7 Reads

Cutaneous chromoblastomycosis effectively treated with local heat monotherapy.

Authors:
T-H Huang C-C E Lan

Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.

Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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http://doi.wiley.com/10.1111/ced.13780
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http://dx.doi.org/10.1111/ced.13780DOI Listing
October 2018
18 Reads

In vitro susceptibility of chromoblastomycosis agents to antifungal drugs: A systematic review.

J Glob Antimicrob Resist 2019 Mar 25;16:108-114. Epub 2018 Sep 25.

Postgraduate Program in Medicine, Medical Sciences, Department of Microbiology, Immunology and Parasitology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Chromoblastomycosis (CBM) is a chronic granulomatous mycosis caused by dematiaceous fungi that affects cutaneous and subcutaneous tissues. The standard antifungal drug for treatment is itraconazole, followed by terbinafine. However, cure rates vary from 15% to 80% when these drugs are used as monotherapy. Read More

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http://dx.doi.org/10.1016/j.jgar.2018.09.010DOI Listing

Chromoblastomycosis in immunosuppressed patients.

Med J Aust 2018 Sep;209(7):295

John Hunter Hospital, Newcastle, NSW.

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September 2018
8 Reads

Identification of chromoblastomycosis agents by PCR based reverse line blot (PCR-RLB) hybridization assay.

Microb Pathog 2018 Dec 5;125:43-47. Epub 2018 Sep 5.

Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; Center of Expertise in Mycology Radboudumc / CWZ, Nijmegen, the Netherlands. Electronic address:

Chromoblastomycosis is one of the most prevalent implantation fungal infections caused by melanized fungi, affecting individuals with certain risk factors with high morbidity due to its recalcitrant nature. It is difficult to identify the etiological agents and thus a suitable reproductive molecular identification method applicable in developing countries has been investigated. We report the identification of four different fungal causative agents of chromoblastomycosis by reverse line blotting hybridization (RLB) based on biotin-labeled PCR products and amine labeled probes to hybridize. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.09.002DOI Listing
December 2018
22 Reads

Chromoblastomycosis: an autochthonous case of a tropical disease.

J Eur Acad Dermatol Venereol 2019 Feb 23;33(2):e76-e78. Epub 2018 Sep 23.

Dermatology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1111/jdv.15221DOI Listing
February 2019

Exophiala dermatitidis isolates from various sources: using alternative invertebrate host organisms (Caenorhabditis elegans and Galleria mellonella) to determine virulence.

Sci Rep 2018 Aug 24;8(1):12747. Epub 2018 Aug 24.

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Exophiala dermatitidis causes chromoblastomycosis, phaeohyphomycosis and fatal infections of the central nervous system of patients with Asian background. It is also found in respiratory secretions from cystic fibrosis (CF) patients. In this study a variety of E. Read More

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http://dx.doi.org/10.1038/s41598-018-30909-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109039PMC
August 2018
12 Reads

An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection.

J Mycol Med 2018 Dec 17;28(4):663-665. Epub 2018 Aug 17.

Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, 14080 Tlalpan, Mexico. Electronic address:

Chromoblastomycosis is defined as a chronic cutaneous and subcutaneous fungal infection caused by melanized or brown-pigmented fungi. A 63-year-old man farmer showed on external and internal part of the right arm, a well-delimited verrucous and hyperkeratotic plaque, with atrophic and cicatricial areas. Direct examination of skin scrapings samples showed the presence of muriform cells, a classic feature of chromoblastomycosis. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.07.008DOI Listing
December 2018
10 Reads

Chromoblastomycosis: clinical experience and review of literature.

Int J Dermatol 2018 Nov 16;57(11):1351-1355. Epub 2018 Aug 16.

Faculty of Medicine of São José do Rio Preto, São Paulo, Brazil.

Background: Chromoblastomycosis is a tropical chronic infectious dermatosis characterized by the moriform bodies. To review all cases of chromoblastomycosis attended in the reference service of dermatology.

Methods: Series of cases of chromoblastomycosis attended in a dermatology reference service. Read More

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http://dx.doi.org/10.1111/ijd.14185DOI Listing
November 2018
3 Reads

Chromoblastomycosis: an etiological, epidemiological, clinical, diagnostic, and treatment update.

An Bras Dermatol 2018 Jul-Aug;93(4):495-506

Dermatology Course, Universidade Federal do Pará, Belém (PA), Brazil.

Chromoblastomycosis is a chronic, granulomatous, suppurative mycosis of the skin and subcutaneous tissue caused by traumatic inoculation of dematiaceous fungi of the family Herpotrichiellaceae. The species Fonsecaea pedrosoi and Cladophialophora carrionii are prevalent in regions where the disease is endemic. Chromoblastomycosis lesions are polymorphous: verrucous, nodular, tumoral, plaque-like, and atrophic. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20187321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063100PMC
September 2018
7 Reads

Uncommon presentation of chromoblastomycosis.

Cutis 2018 Jun;101(6):442;447;448

Department of Dermatology, KEM Hospital, Pune, Maharashtra, India.

Chromoblastomycosis is an uncommon subcutaneous mycosis seen in the tropical and subtropical regions that is caused by traumatic inoculation of a specific group of dematiaceous fungi through the skin. It is a therapeutic challenge due to its recalcitrant nature. Although there currently is no evidence-based treatment protocol, itraconazole and terbinafine are considered drugs of first choice. Read More

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Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil.

PLoS Negl Trop Dis 2018 07 26;12(7):e0006675. Epub 2018 Jul 26.

Laboratory of Mycology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil.

Background: Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species may differ in their epidemiologic aspects, clinical presentation, and treatment response. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080783PMC
July 2018
31 Reads

Sclerotic Cells: Secretion of Aspartic-Type Peptidase and Susceptibility to Peptidase Inhibitors.

Front Microbiol 2018 29;9:1383. Epub 2018 Jun 29.

Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

is a dematiaceous fungus and the main causative agent of chromoblastomycosis that is a chronic disease usually affecting the human skin and subcutaneous tissues, which causes deformations and incapacities, being frequently refractory to available therapies. A typical globe-shaped, multiseptated and pigmented cells, known as sclerotic cells, are found in the lesions of infected individuals. In the present work, we have investigated the production of aspartic-type peptidase in sclerotic cells as well as the effect of peptidase inhibitors (PIs) on its enzymatic activity and viability. Read More

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http://dx.doi.org/10.3389/fmicb.2018.01383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033999PMC
June 2018
3 Reads

Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam.

Mycopathologia 2019 Feb 4;184(1):115-119. Epub 2018 Jul 4.

Department of Parasitology, Vietnam Military Medical University (VMMU), Phung Hung Street, Ha Dong Town, Hanoi, Vietnam.

Background: Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues caused by different melanized fungi. The disease occurs worldwide, particularly in tropical and subtropical regions but not reported in Vietnam. A 47-year-old women was admitted to hospital 103, Hanoi, Vietnam, with a 10-year lasting lesion on backside of her right shank. Read More

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http://dx.doi.org/10.1007/s11046-018-0284-3DOI Listing
February 2019
20 Reads

Melanin particles isolated from the fungus Fonsecaea pedrosoi activates the human complement system.

Mem Inst Oswaldo Cruz 2018 Jun 25;113(8):e180120. Epub 2018 Jun 25.

Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Professor Paulo de Góes, Rio de Janeiro, RJ, Brasil.

Background: Melanin production has been associated with virulence in various pathogenic fungi, including Fonsecaea pedrosoi, the major etiological agent for chromoblastomycosis, a subcutaneous fungal disease that occurs in South America.

Objective: The aim of this study was to evaluate the effects of acid-basic extracted F. pedrosoi melanin particles and fungal cell ghosts obtained by Novozym 234 treatment on their ability to activate the human complement system. Read More

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http://dx.doi.org/10.1590/0074-02760180120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014723PMC
June 2018
4 Reads

Galleria mellonella as a model invertebrate host for the study of muriform cells of dematiaceous fungi.

Future Microbiol 2018 07 21;13:1021-1028. Epub 2018 Jun 21.

Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.

Aim: To study the pathogenesis of chromoblastomycosis using the alternative model host Galleria mellonella.

Methodology: We analyzed the virulence of different dematiaceous fungal strains and the host immune responses (hemocytes density and morphological changes) to Fonsecaea monophora by the alternative infection model. Then detected the development of the pathogenic muriform cells within larvae under microscope. Read More

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http://dx.doi.org/10.2217/fmb-2018-0036DOI Listing
July 2018
24 Reads

First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe.

Clin Exp Dermatol 2018 12 8;43(8):925-927. Epub 2018 Jun 8.

Department of Dermatology Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Carretera de Canyet s/n, Badalona, 08916, Barcelona, Spain.

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http://dx.doi.org/10.1111/ced.13659DOI Listing
December 2018
1 Read

Mechanisms of copper and zinc homeostasis in pathogenic black fungi.

Fungal Biol 2018 06 13;122(6):526-537. Epub 2017 Dec 13.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

Black fungi comprise a diverse group of melanized microorganisms, many of which are able to infect humans. One of the recognized diseases that arise with black fungi infection is chromoblastomycosis, a neglected implantation mycosis. Considering their ecology, black fungi may face conditions with distinct metal availability. Read More

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http://dx.doi.org/10.1016/j.funbio.2017.12.002DOI Listing
June 2018
3 Reads

Case Report: Successful Treatment of Chromoblastomycosis Caused by in a Patient with Psoriasis Using Itraconazole and Acitretin.

Am J Trop Med Hyg 2018 Jul 17;99(1):124-126. Epub 2018 May 17.

Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China.

Chromoblastomycosis is a worldwide chronic subcutaneous infection caused by dematiaceous fungi and clinically characterized by verrucous lesions. Herein, we report a rare case of chromoblastomycosis caused by in a 60-year-old male carpenter with a 40-year history of psoriasis from Shandong in northern China. A fungal infection coexisting with psoriasis presents a management dilemma. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085797PMC
July 2018
3 Reads

[Extensive cutaneous chromomycosis: Efficacy of combined terbinafine and cryotherapy].

Ann Dermatol Venereol 2018 Aug - Sep;145(8-9):512-515. Epub 2018 May 17.

Service de dermatologie, hôpital militaire Moulay Ismail, 50000 Meknès, Maroc; Faculté de médecine et de pharmacie, université Sidi Mohammed Ben Abdellah USMBA, 30000 Fès, Maroc.

Background: Chromomycosis is a chronic fungal skin infection, mainly affecting the limbs. It is responsible for severe morbidity and its treatment remains long and disappointing. Rarely described in Morocco, we report a new observation that has evolved very well under treatment combining terbinafine and cryotherapy over a short duration. Read More

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http://dx.doi.org/10.1016/j.annder.2018.04.005DOI Listing
February 2019
3 Reads

Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents.

Med Mycol 2019 Feb;57(2):260-263

Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous infection caused by melanized fungal species. We quantified the extractable melanin of 77 strains of CBM agents distributed within five genera. Moreover, resistance to oxidative stress was evaluated in strains exposed or not to the melanin inhibitor tricyclazole. Read More

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http://dx.doi.org/10.1093/mmy/myy013DOI Listing
February 2019
9 Reads

Endobronchial Topical Amphotericin B Instillation for Pulmonary Chromomycosis After Lung Transplantation: A Case Report.

Transplant Proc 2018 Apr;50(3):939-942

Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

We report a very rare case of pulmonary chromomycosis caused by Scedosporium prolificans that developed after lung transplantation and was successfully treated with endobronchial topical amphotericin B instillation. The subject was a woman in her 50s with a history of bilateral lobar lung transplantation from living donors for idiopathic pulmonary hypertension. Eight years after the lung transplantation, chest radiography X-ray and computed tomography showed an abnormal shadow in the right lung. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345173088
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http://dx.doi.org/10.1016/j.transproceed.2017.12.028DOI Listing
April 2018
11 Reads

From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi.

Med Mal Infect 2018 Jun 12;48(4):278-285. Epub 2018 Apr 12.

Service de bactériologie, virologie, parasitologie, centre hospitalier universitaire de La Réunion, site Sud, BP 350, 97448 Saint-Pierre cedex, Reunion. Electronic address:

Objective: Infections caused by dematiaceous fungi are more common in tropical and subtropical areas. We aimed to describe the clinical, microbiological and therapeutic aspects of case patients diagnosed at a University Hospital located on an Indian Ocean island.

Patients And Methods: We performed an observational retrospective study of infections caused by dematiaceous fungi diagnosed at the University Hospital of Saint-Pierre, Reunion, from 2000 to 2015. Read More

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http://dx.doi.org/10.1016/j.medmal.2017.09.011DOI Listing
June 2018
4 Reads

Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis.

Antimicrob Agents Chemother 2018 Jun 25;62(6). Epub 2018 May 25.

Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands

Our studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with , , , , , , , and This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of and . Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.00270-18
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http://dx.doi.org/10.1128/AAC.00270-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971613PMC
June 2018
6 Reads

Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina.

Med Mycol Case Rep 2018 Jun 8;20:35-38. Epub 2017 Dec 8.

Ramos Mejia Hospital, Parasitology Unit, Mycology Branch, Buenos Aires C1221ADC, Argentina.

Chromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. has a global distribution along the equator. Read More

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http://dx.doi.org/10.1016/j.mmcr.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852295PMC
June 2018
49 Reads

A Man Who Harvest Peanuts With Verrucous Lesions in His Right Index Finger.

Am J Med Sci 2018 03 22;355(3):e7. Epub 2017 Nov 22.

Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Denver Colorado and Anschutz Medical Campus, Denver, Colorado.

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http://dx.doi.org/10.1016/j.amjms.2017.11.010DOI Listing
March 2018
3 Reads

Black yeasts in the omics era: Achievements and challenges.

Med Mycol 2018 Apr;56(suppl_1):32-41

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

Black yeasts (BY) comprise a group of polyextremotolerant fungi, mainly belonging to the order Chaetothyriales, which are capable of colonizing a wide range of extreme environments. The tolerance to hostile habitats can be explained by their intrinsic ability to survive under acidic, alkaline, and toxic conditions, high temperature, low nutrient availability, and osmotic and mechanical stress. Occasionally, some species can cause human chromoblastomycosis, a chronic subcutaneous infection, as well as disseminated or cerebral phaeohyphomycosis. Read More

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http://dx.doi.org/10.1093/mmy/myx129DOI Listing
April 2018
5 Reads

Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production.

PLoS Negl Trop Dis 2018 02 26;12(2):e0006237. Epub 2018 Feb 26.

Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China.

Fonsecaea pedrosoi (F. pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843349PMC
February 2018
21 Reads

Genetic manipulation of Fonsecaea pedrosoi using particles bombardment and Agrobacterium mediated transformation.

Microbiol Res 2018 Mar 2;207:269-279. Epub 2018 Jan 2.

Programa de Pós-graduação em Ciências e Tecnologias em Saúde, Faculdade de Ceilândia, Universidade de Brasília, Brasília, DF, Brazil; Laboratório de Imunologia Aplicada, Instituto de Biologia, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF, Brazil; Programa de Pós-graduação em Engenharia de Bioprocessos e Biotecnologia, Setor de Ciências Biológicas, Departamento de Patologia Básica, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address:

Fonsecaea pedrosoi, a melanized fungal pathogen that causes Chromoblastomycosis, a human disease with a worldwide distribution. Biolistic is a widely used technique for direct delivery of genetic material into intact cells by particles bombardment. Another well-established transformation method is Agrobacterium-mediated transformation (ATMT), which involves the transfer of a T-DNA from the bacterium to the target cells. Read More

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http://dx.doi.org/10.1016/j.micres.2018.01.001DOI Listing
March 2018
4 Reads

Melanization of a meristematic mutant of Fonsecaea monophora increase the pathogenesis in a BALB/c mice infection model.

Med Mycol 2018 Nov;56(8):979-986

Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.

The role of melanin in agents of chromoblastomycosis in vivo still remains unclear. In this study, we addressed the question in a BALB/c mice infection model by using an albino mutant, which generated from a melanized meristematic mutant of F. monophora. Read More

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http://dx.doi.org/10.1093/mmy/myx148DOI Listing
November 2018
3 Reads

Image Gallery: Uncommon presentation of facial chromoblastomycosis caused by Cladophialophora carrionii.

Authors:
R-J Wang R-Y Li

Br J Dermatol 2017 12;177(6):e356

Department of Dermatology, Peking University First Hospital, Beijing, China.

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http://dx.doi.org/10.1111/bjd.16039DOI Listing
December 2017
1 Read