1,203 results match your criteria Chromoblastomycosis

Subcutaneous mycoses in Ethiopia: a retrospective study in a single dermatology center.

Trans R Soc Trop Med Hyg 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatovenereology, School of Medicine, College of Health Sciences, Addis Ababa University, Zambia st, Addis Ababa, Ethiopia 2380.

Background: The magnitude of various types of subcutaneous mycoses in Ethiopia is unknown.

Methods: We performed a 5-y retrospective review of confirmed cases at ALERT hospital dermatology clinics.

Result: Confirmed cases of subcutaneous mycoses included chromoblastomycosis (n=12) and mycetoma (n=8). Read More

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Doubly Misdiagnosed: Exophiala Masquerading as Squamous Cell Carcinoma and Chromoblastomycosis.

Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology, University of Virginia Health System, Charlottesville, VA.

Abstract: Deep cutaneous fungal infections (DCFI) can arise in the setting of skin trauma and immunosuppression. DCFI may be secondary to chromoblastomycosis, which is typically characterized by pseudoepitheliomatous hyperplasia histologically and can be mistaken for squamous cell carcinoma. In addition, "copper penny" spore-like pigmented yeast forms on Grocott's methenamine silver stain can suggest chromoblastomycosis, but this finding is not specific. Read More

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Silver(I) and Copper(II) Complexes of 1,10-Phenanthroline-5,6-Dione Against : A Focus on the Interaction With Human Macrophages and Larvae.

Front Microbiol 2021 27;12:641258. Epub 2021 Apr 27.

Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos (LTBBF), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

is a dematiaceous fungus that causes mainly chromoblastomycosis, but also disseminated infections such as phaeohyphomycosis and mycetoma. These diseases are extremely hard to treat and often refractory to current antifungal therapies. In this work, we have evaluated the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based complexes, [Ag (phendione)]ClO and [Cu(phendione)](ClO). Read More

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Neutrophil Extracellular Traps Serve as Key Effector Molecules in the Protection Against Phialophora verrucosa.

Mycopathologia 2021 May 19. Epub 2021 May 19.

Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Phialophora verrucosa (P. verrucosa) is a pathogen that can cause chromoblastomycosis and phaeohyphomycosis. Recent evidence suggests that neutrophils can produce neutrophil extracellular traps (NETs) that can protect against invasive pathogens. Read More

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Presence of hyphae in chromoblastomycosis examinations: an enigma to be solved.

An Bras Dermatol 2021 May 15. Epub 2021 May 15.

Dermatology Clinic, Santa Casa de Misericórdia, São Paulo, SP, Brazil.

The detection of muriform cells in direct mycological or anatomopathological examination is considered pathognomonic for chromoblastomycosis. The morphological aspect that these fungal structures acquire were called "Borelli spiders", when associated with hyphae. Reports of this association have been described for decades, initially related to more pathogenic agents of this mycosis. Read More

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Effect of melanin biosynthesis inhibition in the antifungal susceptibility of chromoblastomycosis agents.

Antimicrob Agents Chemother 2021 May 10. Epub 2021 May 10.

Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2400 - CEP: 90035-003, Porto Alegre - RS, Brazil.

Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by genera of melanized fungi: , , , and Melanin is a virulence factor known to influence antifungal susceptibility. A specific inhibitor of melanin biosynthesis is tricyclazole. The aim of this study was to evaluate the effect of melanin inhibition on antifungal susceptibility of chromoblastomycosis agents and describe the susceptibility profile of some unusual CBM agents. Read More

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Lower Limb Nodulo-ulcerative Lesion in Kidney Transplant Recipient - An Unusual Diagnosis.

Indian J Nephrol 2020 Nov-Dec;30(6):427-429. Epub 2020 Nov 19.

Department of Nephrology, S M S Medical College, Jaipur, Rajasthan, India.

A 56-year-old kidney transplant recipient presented with a progressive cauliflower-like growth on the plantar surface of the right foot and on workup found to have chromoblastomycosis, which was successfully treated by antifungal agent and surgical excision with no recurrence. Chromoblastomycosis belongs to the heterogeneous group of subcutaneous mycoses. It is caused by various pigmented (dematiaceous) fungi, which gain entry into the skin via traumatic implantation. Read More

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November 2020

Rapid classification of chromoblastomycosis agents genera by infrared spectroscopy and chemometrics supervised by sequencing of rDNA regions.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 10;254:119647. Epub 2021 Mar 10.

Department of Sciences, Humanities and Education, Postgraduate Program in Health Promotion, Postgraduate Program in Environmental Technology, Universidade de Santa Cruz do Sul, Avenida Independência, 2293, CEP: 96815-900 Santa Cruz do Sul, RS, Brazil. Electronic address:

Chromoblastomycosis (CBM) is a skin and subcutaneous infection caused by species of seven fungal genera. Identification of CBM species is performed by DNA sequencing of one or more genes, which becomes a time-consuming work. Fourier Transform Infrared Spectroscopy (FTIR) has been used for the identification of other microorganisms, however, only one CBM genus was evaluated by FTIR analysis to date. Read More

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Chromoblastomycosis caused by Fonsecaea monophora in Mexico.

J Mycol Med 2021 Jun 19;31(2):101114. Epub 2021 Jan 19.

Departamento de Ecología de Agentes Patógenos. Hospital General "Dr. Manuel Gea González", 14080 Tlalpan, Ciudad de México, Mexico. Electronic address:

Chromoblastomycosis is a chronic subcutaneous fungal infection caused by melanized fungi. It is usually an occupational mycosis affecting people in rural areas in tropical and subtropical regions. We present two cases of chromoblastomycosis in Mexican farmers, characterized by skin verrucous plaques. Read More

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Melanin and chromoblastomycosis agents: Characterization, functions, and relation with antifungals.

J Basic Microbiol 2021 Mar 12;61(3):203-211. Epub 2021 Feb 12.

Department of Internal Medicine, Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Melanins are a diverse group of dark pigments with similar properties. In fungi, the most studied is the dihydroxynaphtalene (DHN)-melanin, present in several species including all the chromoblastomycosis agents, a chronic, disabling, and recalcitrant subcutaneous mycosis. It is synthesized in a pathway known as the pentaketide pathway, which has the agrochemical tricyclazole as an inhibitor, widely used in in vitro studies because it does not prevent the growth of fungi. Read More

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Chromoblastomycosis Caused by -Proven Cases from Mexico.

J Fungi (Basel) 2021 Jan 29;7(2). Epub 2021 Jan 29.

Center of Expertise in Mycology, Radboud University Medical Center/Canisius Wilhelmina Hospital, 6525GA Nijmegen, The Netherlands.

Chromoblastomycosis is a chronic severely mutilating disease caused by fungi of the order . Classically, has been listed among these etiologic agents. This species is known to occur in the environment and has been found to cause other infections like phaeohyphomycosis, while reported cases of chromoblastomycosis are scant. Read More

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January 2021

An Urban Case of Chromoblastomycosis in the United States.

Cureus 2021 Feb 4;13(2):e13136. Epub 2021 Feb 4.

Internal Medicine, Methodist Health System, Dallas, USA.

Rash is a common chief complaint in the emergency room. Infection and pathogen colonization of the skin are among the most common causes of rash. Workers throughout the world are occupationally exposed to fungal species, increasing the likelihood of infection. Read More

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February 2021

The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry?

PLoS Negl Trop Dis 2021 02 9;15(2):e0009092. Epub 2021 Feb 9.

Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

The World Health Organization (WHO) considers mycetoma, chromoblastomycosis, and paracoccidioidomycosis to be fungal neglected tropical diseases (FNTDs). Depending on climatic, cultural, and economic contexts, these diseases have a similar geographical distribution as many other diseases, particularly tuberculosis (TB) and malaria, but are often less targeted by the national and many international healthcare systems. Another subgroup of fungal infections, such as candidiasis, cryptococcosis, pneumocystosis, histoplasmosis, and to a lesser extent, aspergillosis, are known as AIDS-related mycoses. Read More

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February 2021

Comparative genomics of opportunistic Phialophora species involved in divergent disease types.

Mycoses 2021 May 26;64(5):555-568. Epub 2021 Jan 26.

Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.

Background: Black opportunists Phialophora verrucosa complex species can cause different disease types in competent and in immunocompromised individuals, but are remarkably overrepresented in CARD9-related infections.

Objectives: To better understand the ecology and potential pathogenicity of opportunistic Phialophora species and reveal eventual genetic parameters associated with the behaviour in vivo and genetic profiles in patients with CARD9 immunodeficiency.

Methods: Genomes of 26 strains belonging to six species of the Phialophora verrucosa complex were sequenced. Read More

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Deep mycoses and pseudomycoses of the foot: a single-center retrospective study of 160 cases, in a tertiary-care center in Mexico.

Foot (Edinb) 2021 Mar 13;46:101770. Epub 2021 Jan 13.

Microbiology Department, Universidad Autónoma De Nuevo León, Mexico.

Background: Deep mycoses and pseudomycoses (DMP) may cause significant disability and even death; however, the reports regarding these diseases, mainly affecting the foot, are scarce.

Objective: To describe the epidemiological, clinical, and diagnostic characteristics of DMP of the foot in 160 patients.

Methods: A retrospective and observational study of DMP affecting the foot was carried out in a tertiary-care center in Mexico for 20 years (from January 2000 to December 2019). Read More

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Chromoblastomycosis by Exophiala jeanselmei associated with squamous cell carcinoma.

J Mycol Med 2021 Mar 7;31(1):101105. Epub 2021 Jan 7.

Department of Dermatology, the Affiliated 3rd Hospital of Hangzhou, Anhui Medical University, Hangzhou, 310009, China. Electronic address:

Chromoblastomycosis is a subcutaneous, chronic, granulomatous mycosis that occurs more frequently in tropical and subtropical countries. Herein, we describe a case of a 90-year-old female patient with diagnosis of chromoblastomycosis by Exophiala jeanselmei with a 22-year evolution who developed a squamous cell carcinoma. In the meantime, She underwent two misdiagnoses and an unnecessary operation. Read More

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[Chromoblastomycosis and phaeohyphomycosis - pathogenesis and laboratory diagnosis].

Klin Mikrobiol Infekc Lek 2020 Jun;26(2):69-75

Laboratory of Clinical Mycology, Institute of Health based in Ostrava, Department of Bacteriology and Mycology, Czech Republic, e-mail:

Chromoblastomycosis and phaeohyphomycosis are less common fungal infections caused by dark-pigmented fungi. Virulence factors play an important role in the pathogenesis of these diseases. One of these factors, muriform cells, are the most important element for differential diagnosis of chromoblastomycosis and phaeohyphomycosis using clinical samples and various staining techniques. Read More

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[Treatment of chromoblastomycosis and phaeohyphomycosis].

Klin Mikrobiol Infekc Lek 2020 Jun;26(2):62-68

Laboratory of Clinical Mycology, Institute of Health based in Ostrava, Department of Bacteriology and Mycology, Czech Republic, e-mail:

Cases of chromoblastomycosis are frequent in certain parts of the world, especially in some developing countries. Clinical manifestations of chromoblastomycosis are typical. To a certain extent, pathogens causing chromoblastomycosis overlap with those causing phaeohyphomycosis. Read More

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[Chromoblastomycosis and phaeohyphomycosis, overlooked fungal diseases].

Klin Mikrobiol Infekc Lek 2020 Jun;26(2):54-61

Laboratory of Clinical Mycology, Institute of Health based in Ostrava, Department of Bacteriology and Mycology, Czech Republic, e-mail:

Dark-pigmented microscopic fungi are worldwide-spread soil saprophytes often found on plant remnants. In chromoblastomycosis, infectious particles of these fungi enter the human body at the site of injury and may cause chronic infection, mainly in tropical and subtropical endemic areas. Chromoblastomycosis is almost exclusively diagnosed in patients with fully functioning immunity, with typically muriform cells present in infected tissue distinguishing this condition from phaeohyphomycosis. Read More

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Immune Sensing and Potential Immunotherapeutic Approaches to Control Chromoblastomycosis.

J Fungi (Basel) 2020 Dec 22;7(1). Epub 2020 Dec 22.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo 05508-000, Brazil.

Chromoblastomycosis (CBM) is a neglected, chronic, and progressive subcutaneous mycosis caused by different species of fungi from the Herpotrichiellaceae family. CBM disease is usually associated with agricultural activities, and its infection is characterized by verrucous, erythematous papules, and atrophic lesions on the upper and lower limbs, leading to social stigma and impacts on patients' welfare. The economic aspect of disease treatment is another relevant issue. Read More

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December 2020

Deletion of pksA attenuates the melanogenesis, growth and sporulation ability and causes increased sensitivity to stress response and antifungal drugs in the human pathogenic fungus Fonsecaea monophora.

Microbiol Res 2021 Mar 5;244:126668. Epub 2020 Dec 5.

Department of Dermatology and Venerology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Fonsecaea monophora, which is very similar to Fonsecaea pedrosoi in morphological features, has been commonly misdiagnosed as F. pedrosoi. Like F. Read More

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Arkh Patol 2020 ;82(6):59-62

M.F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia.

The paper describes a case of chromoblastomycosis, a rare implantation mycosis in the Russian Federation. It gives data on the prevalence, etiology, and clinical presentations of the disease, and the diagnostic possibilities. Emphasis is laid on the leading role of a pathomorphological study in the diagnosis of chromoblastomycosis in non-endemic countries, including Russia. Read More

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December 2020

-Mediated Transformation of and for Host-Environment Interaction Studies.

J Fungi (Basel) 2020 Nov 30;6(4). Epub 2020 Nov 30.

Engineering Bioprocess and Biotechnology Graduate Program, Department of Bioprocess Engineering and Biotechnology, Federal University of Paraná, Curitiba 81530-000, Brazil.

The fungal genus contains etiological agents of human chromoblastomycosis, a (sub)tropical, (sub)cutaneous implantation disease caused by plant contact. The invasive potential differs significantly between species. Infections by are believed to originate from the environment and the species has been reported as one of the main causative agents of the disease, but also of cases of primary brain infection. Read More

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November 2020

Prediction of itraconazole minimum inhibitory concentration for Fonsecaea pedrosoi using Fourier Transform Infrared Spectroscopy (FTIR) and chemometrics.

PLoS One 2020 2;15(12):e0243231. Epub 2020 Dec 2.

Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Fonsecaea pedrosoi is one of the main agents of chromoblastomycosis, a chronic subcutaneous mycosis. Itraconazole (ITC) is the most used antifungal in its treatment, however, in vitro antifungal susceptibility tests are important to define the best therapy. These tests are standardized by the Clinical and Laboratory Standards Institute (CLSI), but these protocols have limitations such as the high complexity, cost and time to conduct. Read More

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January 2021

Mycobacterium marinum infection simulating chromomycosis: a case report.

Rev Inst Med Trop Sao Paulo 2020 27;62:e95. Epub 2020 Nov 27.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Skins infections caused by Mycobacterium marinum occur only rarely. We report one case of chronic and extensive M. marinum cutaneous infection simulating chromoblastomycosis and review the pertinent literature. Read More

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January 2021

Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile.

J Mycol Med 2021 Mar 21;31(1):101086. Epub 2020 Nov 21.

Manchester Fungal Infection Group, faculty of medicine, biology and health, university of Manchester and Manchester academic health science centre, Manchester, UK.

Due to limited access to more powerful diagnostic tools, there are few data on the burden of fungal infections in Côte d'Ivoire, despite a high HIV and TB burden and many cutaneous diseases. Here we estimate the burden of serious fungal infections in this sub-Saharan country with a health profiling description. National demographics were used and PubMed searches to retrieve all published articles on fungal infections in Côte d'Ivoire and other bordering countries in West Africa. Read More

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New molecular marker for phylogenetic reconstruction of black yeast-like fungi (Chaetothyriales) with hypothetical EIF2AK2 kinase gene.

Fungal Biol 2020 12 24;124(12):1032-1038. Epub 2020 Sep 24.

Núcleo de Pós-Graduação, Ensino e Pesquisa, Hospital Santa Casa de Belo Horizonte, Brazil. Electronic address:

In eukaryotes, phosphorylation of the α-subunit of eIF2 is a mechanism to adjust cellular gene expression profiles in response to specific signals. The eIF2α kinases are a group of serine-threonine kinases that perform important functions in response to infection, proteotoxicity, and nutrient scavenging. The conserved nature of eIF2α kinases among fungi makes them potential evolutionary markers, which may contribute to deeper understanding of taxonomy and evolution. Read More

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December 2020

Environmental Screening of Agents of Chromoblastomycosis Using Rolling Circle Amplification.

J Fungi (Basel) 2020 Nov 17;6(4). Epub 2020 Nov 17.

Postgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology, Federal University of Parana, Curitiba 81531-980, Brazil.

Chromoblastomycosis is a chronic, cutaneous or subcutaneous mycosis characterized by the presence of muriform cells in host tissue. Implantation disease is caused by melanized fungi related to black yeasts, which, in humid tropical climates, are mainly members of the genus . In endemic areas of Brazil, and are the prevalent species. Read More

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November 2020

Conidia and Hyphae Activate Neutrophils Distinctly: Requirement of TLR-2 and TLR-4 in Neutrophil Effector Functions.

Front Immunol 2020 21;11:540064. Epub 2020 Oct 21.

Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Chromoblastomycosis is a chronic and progressive subcutaneous mycosis caused mainly by the fungus . The infection is characterized by erythematous papules and histological sections demonstrating an external layer of fibrous tissue and an internal layer of thick granulomatous inflammatory tissue containing mainly macrophages and neutrophils. Several groups are studying the roles of the innate and adaptive immune systems in infection; however, few studies have focused on the role of neutrophils in this infection. Read More

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