1,101 results match your criteria Chromoblastomycosis
Med Mycol Case Rep 2019 Mar 25;23:31-33. Epub 2018 Oct 25.
Laboratorio de Micologia y Fitopatologia (LAMFU), Departamento de Ciencias Biológicas, Facultad de ciencias, Universidad de los Andes, Bogota 111711, Colombia.
Chromoblastomycosis is a chronic cutaneous and subcutaneous mycosis, is caused by dematiaceous fungi, the most frequently implicated are and We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported. Read More
Indian J Dermatol 2018 Nov-Dec;63(6):496-501
Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.
Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.
Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More
Pan Afr Med J 2018 28;30:187. Epub 2018 Jun 28.
Service de Dermatologie et de Vénéréologie, CHU Ibn Rochd, Casablanca, Maroc.
We report the case of a 13-year old female patient from rural areas presenting with papulonodular lesion of 4/3cm in the lower third of the right leg, evolving over the last two years. Skin biopsy showed papillomatous hyperplasia with neutrophilic microabscess and spores. Direct mycological examination showed fumagoid bodies and Fonsecaea pedrosoi was isolated from culture. Read More
Front Microbiol 2018 9;9:2211. Epub 2018 Oct 9.
Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, Brazil.
The fungal genus comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The present study aimed to evaluate a model of infection in plant and animal hosts to understand the parameters of trans-kingdom pathogenicity. Read More
Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.
Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
J Glob Antimicrob Resist 2018 Sep 25. Epub 2018 Sep 25.
Postgraduate Program in Medicine: Medical Sciences, Department of Microbiology, Immunology and Parasitology, Universidade Federal do Rio Grande do Sul, Brazil. Electronic address:
Chromoblastomycosis (CBM) is a chronic granulomatous mycosis caused by dematiaceous fungi, which affects cutaneous and subcutaneous tissues. The standard antifungal drug for treatment is itraconazole, followed by terbinafine. However, the cure rates vary from 15 to 80% when these drugs are used in monotherapy. Read More
Med J Aust 2018 Sep;209(7):295
John Hunter Hospital, Newcastle, NSW.
Microb Pathog 2018 Dec 5;125:43-47. Epub 2018 Sep 5.
Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; Center of Expertise in Mycology Radboudumc / CWZ, Nijmegen, the Netherlands. Electronic address:
Chromoblastomycosis is one of the most prevalent implantation fungal infections caused by melanized fungi, affecting individuals with certain risk factors with high morbidity due to its recalcitrant nature. It is difficult to identify the etiological agents and thus a suitable reproductive molecular identification method applicable in developing countries has been investigated. We report the identification of four different fungal causative agents of chromoblastomycosis by reverse line blotting hybridization (RLB) based on biotin-labeled PCR products and amine labeled probes to hybridize. Read More
J Eur Acad Dermatol Venereol 2018 Aug 30. Epub 2018 Aug 30.
Dermatology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Sci Rep 2018 Aug 24;8(1):12747. Epub 2018 Aug 24.
Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Exophiala dermatitidis causes chromoblastomycosis, phaeohyphomycosis and fatal infections of the central nervous system of patients with Asian background. It is also found in respiratory secretions from cystic fibrosis (CF) patients. In this study a variety of E. Read More
J Mycol Med 2018 Dec 17;28(4):663-665. Epub 2018 Aug 17.
Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, 14080 Tlalpan, Mexico. Electronic address:
Chromoblastomycosis is defined as a chronic cutaneous and subcutaneous fungal infection caused by melanized or brown-pigmented fungi. A 63-year-old man farmer showed on external and internal part of the right arm, a well-delimited verrucous and hyperkeratotic plaque, with atrophic and cicatricial areas. Direct examination of skin scrapings samples showed the presence of muriform cells, a classic feature of chromoblastomycosis. Read More
Int J Dermatol 2018 Nov 16;57(11):1351-1355. Epub 2018 Aug 16.
Faculty of Medicine of São José do Rio Preto, São Paulo, Brazil.
Background: Chromoblastomycosis is a tropical chronic infectious dermatosis characterized by the moriform bodies. To review all cases of chromoblastomycosis attended in the reference service of dermatology.
Methods: Series of cases of chromoblastomycosis attended in a dermatology reference service. Read More
An Bras Dermatol 2018 Jul-Aug;93(4):495-506
Dermatology Course, Universidade Federal do Pará, Belém (PA), Brazil.
Chromoblastomycosis is a chronic, granulomatous, suppurative mycosis of the skin and subcutaneous tissue caused by traumatic inoculation of dematiaceous fungi of the family Herpotrichiellaceae. The species Fonsecaea pedrosoi and Cladophialophora carrionii are prevalent in regions where the disease is endemic. Chromoblastomycosis lesions are polymorphous: verrucous, nodular, tumoral, plaque-like, and atrophic. Read More
Cutis 2018 Jun;101(6):442;447;448
Department of Dermatology, KEM Hospital, Pune, Maharashtra, India.
Chromoblastomycosis is an uncommon subcutaneous mycosis seen in the tropical and subtropical regions that is caused by traumatic inoculation of a specific group of dematiaceous fungi through the skin. It is a therapeutic challenge due to its recalcitrant nature. Although there currently is no evidence-based treatment protocol, itraconazole and terbinafine are considered drugs of first choice. Read More
PLoS Negl Trop Dis 2018 07 26;12(7):e0006675. Epub 2018 Jul 26.
Laboratory of Mycology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil.
Background: Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species may differ in their epidemiologic aspects, clinical presentation, and treatment response. Read More
Front Microbiol 2018 29;9:1383. Epub 2018 Jun 29.
Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
is a dematiaceous fungus and the main causative agent of chromoblastomycosis that is a chronic disease usually affecting the human skin and subcutaneous tissues, which causes deformations and incapacities, being frequently refractory to available therapies. A typical globe-shaped, multiseptated and pigmented cells, known as sclerotic cells, are found in the lesions of infected individuals. In the present work, we have investigated the production of aspartic-type peptidase in sclerotic cells as well as the effect of peptidase inhibitors (PIs) on its enzymatic activity and viability. Read More
Mycopathologia 2018 Jul 4. Epub 2018 Jul 4.
Department of Parasitology, Vietnam Military Medical University (VMMU), Phung Hung Street, Ha Dong Town, Hanoi, Vietnam.
Background: Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues caused by different melanized fungi. The disease occurs worldwide, particularly in tropical and subtropical regions but not reported in Vietnam. A 47-year-old women was admitted to hospital 103, Hanoi, Vietnam, with a 10-year lasting lesion on backside of her right shank. Read More
Mem Inst Oswaldo Cruz 2018 Jun 25;113(8):e180120. Epub 2018 Jun 25.
Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Professor Paulo de Góes, Rio de Janeiro, RJ, Brasil.
Background: Melanin production has been associated with virulence in various pathogenic fungi, including Fonsecaea pedrosoi, the major etiological agent for chromoblastomycosis, a subcutaneous fungal disease that occurs in South America.
Objective: The aim of this study was to evaluate the effects of acid-basic extracted F. pedrosoi melanin particles and fungal cell ghosts obtained by Novozym 234 treatment on their ability to activate the human complement system. Read More
Future Microbiol 2018 07 21;13:1021-1028. Epub 2018 Jun 21.
Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Aim: To study the pathogenesis of chromoblastomycosis using the alternative model host Galleria mellonella.
Methodology: We analyzed the virulence of different dematiaceous fungal strains and the host immune responses (hemocytes density and morphological changes) to Fonsecaea monophora by the alternative infection model. Then detected the development of the pathogenic muriform cells within larvae under microscope. Read More
An Bras Dermatol 2018 Jun;93(3):475-476
Research Department, Ecology of Pathogen Agents Sector, Hospital "Dr. Manuel Gea González", Ciudad del Mexico, Mexico.
Clin Exp Dermatol 2018 12 8;43(8):925-927. Epub 2018 Jun 8.
Department of Dermatology Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Carretera de Canyet s/n, Badalona, 08916, Barcelona, Spain.
Fungal Biol 2018 06 13;122(6):526-537. Epub 2017 Dec 13.
Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:
Black fungi comprise a diverse group of melanized microorganisms, many of which are able to infect humans. One of the recognized diseases that arise with black fungi infection is chromoblastomycosis, a neglected implantation mycosis. Considering their ecology, black fungi may face conditions with distinct metal availability. Read More
Am J Trop Med Hyg 2018 Jul 17;99(1):124-126. Epub 2018 May 17.
Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China.
Chromoblastomycosis is a worldwide chronic subcutaneous infection caused by dematiaceous fungi and clinically characterized by verrucous lesions. Herein, we report a rare case of chromoblastomycosis caused by in a 60-year-old male carpenter with a 40-year history of psoriasis from Shandong in northern China. A fungal infection coexisting with psoriasis presents a management dilemma. Read More
Med Mycol 2018 Apr 14. Epub 2018 Apr 14.
Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous infection caused by melanized fungal species. We quantified the extractable melanin of 77 strains of CBM agents distributed within five genera. Moreover, resistance to oxidative stress was evaluated in strains exposed or not to the melanin inhibitor tricyclazole. Read More
Transplant Proc 2018 Apr;50(3):939-942
Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
We report a very rare case of pulmonary chromomycosis caused by Scedosporium prolificans that developed after lung transplantation and was successfully treated with endobronchial topical amphotericin B instillation. The subject was a woman in her 50s with a history of bilateral lobar lung transplantation from living donors for idiopathic pulmonary hypertension. Eight years after the lung transplantation, chest radiography X-ray and computed tomography showed an abnormal shadow in the right lung. Read More
Med Mal Infect 2018 Jun 12;48(4):278-285. Epub 2018 Apr 12.
Service de bactériologie, virologie, parasitologie, centre hospitalier universitaire de La Réunion, site Sud, BP 350, 97448 Saint-Pierre cedex, Reunion. Electronic address:
Objective: Infections caused by dematiaceous fungi are more common in tropical and subtropical areas. We aimed to describe the clinical, microbiological and therapeutic aspects of case patients diagnosed at a University Hospital located on an Indian Ocean island.
Patients And Methods: We performed an observational retrospective study of infections caused by dematiaceous fungi diagnosed at the University Hospital of Saint-Pierre, Reunion, from 2000 to 2015. Read More
Antimicrob Agents Chemother 2018 Jun 25;62(6). Epub 2018 May 25.
Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands
Our studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with , , , , , , , and This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of and . Read More
Med Mycol Case Rep 2018 Jun 8;20:35-38. Epub 2017 Dec 8.
Ramos Mejia Hospital, Parasitology Unit, Mycology Branch, Buenos Aires C1221ADC, Argentina.
Chromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. has a global distribution along the equator. Read More
Am J Med Sci 2018 03 22;355(3):e7. Epub 2017 Nov 22.
Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Denver Colorado and Anschutz Medical Campus, Denver, Colorado.
Med Mycol 2018 Apr;56(suppl_1):32-41
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Black yeasts (BY) comprise a group of polyextremotolerant fungi, mainly belonging to the order Chaetothyriales, which are capable of colonizing a wide range of extreme environments. The tolerance to hostile habitats can be explained by their intrinsic ability to survive under acidic, alkaline, and toxic conditions, high temperature, low nutrient availability, and osmotic and mechanical stress. Occasionally, some species can cause human chromoblastomycosis, a chronic subcutaneous infection, as well as disseminated or cerebral phaeohyphomycosis. Read More
PLoS Negl Trop Dis 2018 02 26;12(2):e0006237. Epub 2018 Feb 26.
Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China.
Fonsecaea pedrosoi (F. pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Read More
Microbiol Res 2018 Mar 2;207:269-279. Epub 2018 Jan 2.
Programa de Pós-graduação em Ciências e Tecnologias em Saúde, Faculdade de Ceilândia, Universidade de Brasília, Brasília, DF, Brazil; Laboratório de Imunologia Aplicada, Instituto de Biologia, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF, Brazil; Programa de Pós-graduação em Engenharia de Bioprocessos e Biotecnologia, Setor de Ciências Biológicas, Departamento de Patologia Básica, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address:
Fonsecaea pedrosoi, a melanized fungal pathogen that causes Chromoblastomycosis, a human disease with a worldwide distribution. Biolistic is a widely used technique for direct delivery of genetic material into intact cells by particles bombardment. Another well-established transformation method is Agrobacterium-mediated transformation (ATMT), which involves the transfer of a T-DNA from the bacterium to the target cells. Read More
Med Mycol 2018 Nov;56(8):979-986
Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
The role of melanin in agents of chromoblastomycosis in vivo still remains unclear. In this study, we addressed the question in a BALB/c mice infection model by using an albino mutant, which generated from a melanized meristematic mutant of F. monophora. Read More
Br J Dermatol 2017 12;177(6):e356
Department of Dermatology, Peking University First Hospital, Beijing, China.
Dermatol Pract Concept 2017 Oct 31;7(4):23-24. Epub 2017 Oct 31.
Department of Dermatology and Venereology All India Institute of Medical Sciences, New Delhi, India.
Chromoblastomycosis is a chronic cutaneous fungal infection commonly caused by and . Dermoscopy is a non-invasive, real-time diagnostic tool for rapid bedside diagnosis of various inflammatory and non-inflammatory disorders and can be an excellent modality for evaluation of cutaneous mycosis, for which it shows characteristic brown dots, crust, scales and yellow orange structures. Read More
Front Immunol 2017 20;8:1572. Epub 2017 Nov 20.
Laboratory of Applied Immunology, Department of Cellular Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
is the main etiologic agent of chromoblastomycosis (CBM), one of the most prevalent subcutaneous mycosis in tropical and subtropical countries. CBM is a poorly characterized chronic infection that commonly starts after transcutaneous inoculation of conidia and saprophytic hyphae of . Recently, we have shown that unlike conidia, hyphae and muriform cells (the parasitic morphotype) of promotes an intense inflammatory response pattern , which comprises the production of an inflammasome-derived cytokine, IL-1β. Read More
Mycoses 2018 Apr 12;61(4):231-236. Epub 2017 Dec 12.
Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
We report a case of chromoblastomycosis due to the presence of large plaque and verrucous hyperplasia lesions on the left upper limb, with elbow abnormal activities, in a 56-year-old male. The diagnosis of chromoblastomycosis was based on gross and microscopic morphologies, histopathological examination and clinical manifestation. Molecular tools were applied to identifying the causative agent Fonsecaea nubica, which is rarely reported to be associated with chromoblastomycosis. Read More
Rev Chilena Infectol 2017 Aug;34(4):404-407
Laboratorio de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú.
Chromoblastomycosis is a neglected and chronic fungal disease, mainly affects the subcutaneous tissue in limbs of people with occupational risk. Here, we report two cases of adult patients from tropical regions of northern Peru, affected with chronic erythematous scaly lesions and multiple blackheads, pain, itching and scarring in older areas of injury. Direct examination of the dermal scales showed typical of this disease fumagoides cells; Fonsecaea pedrosoi and Fonsecaea sp. Read More
Persoonia 2017 Jun 2;38:1-19. Epub 2016 Aug 2.
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, P.R. China.
as defined by its type species is a genus of , and a member of the group known as 'black yeasts and relatives'. has been reported from mutilating human infections such as chromoblastomycosis, disseminated phaeohyphomycosis and mycetoma, while morphologically similar fungi are rather commonly isolated from the environment. Phenotypes are insufficient for correct species identification, and molecular data have revealed significant genetic variation within the complex of species currently identified as or . Read More
Cutis 2017 10;100(4):E13-E14
Hollywood Dermatology, Florida, USA.
Med Mycol 2018 Jun;56(4):395-405
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taiwan.
Chromoblastomycosis (CBM) is an implantation mycosis characterized by the presence of pigmented muriform cells in tissue. CBM is endemic in Taiwan, but only three formal cases have been reported to date because of underreporting. To describe and update its epidemiologic features, we report a series of 30 cases between 2003 and 2016 at a single medical center. Read More
Front Microbiol 2017 9;8:1924. Epub 2017 Oct 9.
Microbiology, Parasitology and Pathology Post-Graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, Brazil.
and are genera of black yeast-like fungi harboring agents of a mutilating implantation disease in humans, along with strictly environmental species. The current hypothesis suggests that those species reside in somewhat adverse microhabitats, and pathogenic siblings share virulence factors enabling survival in mammal tissue after coincidental inoculation driven by pathogenic adaptation. A comparative genomic analysis of environmental and pathogenic siblings of and was undertaken, including assembly of from plant material. Read More
Clin Exp Dermatol 2018 Jan 13;43(1):75-76. Epub 2017 Oct 13.
Department of Dermatology, Division of Dermatology of Hospital das Clínicas, São Paulo University, School of Medicine, Sao Paulo, Brazil.
Pol J Pathol 2017;68(2):182-184
Case Report: We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Read More
J Photochem Photobiol B 2017 Nov 18;176:112-117. Epub 2017 Sep 18.
Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, Guangzhou 510120, China. Electronic address:
Chromoblastomycosis (CBM), one of the neglected tropical diseases, is hard to cure and easy to be recurrent. Many studies suggest that macrophage is involved in the pathogenesis of chromoblastomycosis and the fungicidal effect of 5-Aminolaevulinic Acid-Based Photodynamic Therapy (ALA-PDT) against F. monophora (one of the main causative agent of chromoblastomycosis) has shown great promise. Read More
Med Mycol 2017 Nov;55(8):896
Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
An Bras Dermatol 2017 Jul-Aug;92(4):478-483
Discipline of Biostatistics of the Medical School - Pontifícia Universidade Católica do Paraná (PUC-PR) - Curitiba (PR), Brazil.
Background:: Histological and mycological changes during itraconazole use have not been totally established in chromoblastomycosis.
Objectives:: To evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment.
Methods:: A histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Read More
J Mycol Med 2017 Sep 25;27(3):312-324. Epub 2017 Aug 25.
Laboratoire de parasitologie-mycologie, CHU de Grenoble-Alpes, CS 10217, 38043 Grenoble cedex 9, France; Laboratoire TIMC-IMAG TheREx, université de Grenoble-Alpes, domaine de la Merci, 38706 La Tronche cedex, France. Electronic address:
Chromoblastomycosis and sporotrichosis are endemic fungal infections of tropical and subtropical regions, including Madagascar. The causal fungi develop in the soil or on plants and infect humans through wounds, either directly (wounding by the plant, through thorns, for example), or through the contact of an existing wound with contaminated soil. For this reason, the lesions predominantly occur on the limbs, and these fungi principally infect people working outside with bare hands and/or feet. Read More
Lancet Infect Dis 2017 11 31;17(11):e367-e377. Epub 2017 Jul 31.
Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Read More