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    1 OF 22

    Genetic manipulation of Fonsecaea pedrosoi using particles bombardment and Agrobacterium mediated transformation.
    Microbiol Res 2018 Mar 2;207:269-279. Epub 2018 Jan 2.
    Programa de Pós-graduação em Ciências e Tecnologias em Saúde, Faculdade de Ceilândia, Universidade de Brasília, Brasília, DF, Brazil; Laboratório de Imunologia Aplicada, Instituto de Biologia, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF, Brazil; Programa de Pós-graduação em Engenharia de Bioprocessos e Biotecnologia, Setor de Ciências Biológicas, Departamento de Patologia Básica, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address:
    Fonsecaea pedrosoi, a melanized fungal pathogen that causes Chromoblastomycosis, a human disease with a worldwide distribution. Biolistic is a widely used technique for direct delivery of genetic material into intact cells by particles bombardment. Another well-established transformation method is Agrobacterium-mediated transformation (ATMT), which involves the transfer of a T-DNA from the bacterium to the target cells. Read More

    Melanization of a meristematic mutant of Fonsecaea monophora increase the pathogenesis in a BALB/c mice infection model.
    Med Mycol 2018 Feb 12. Epub 2018 Feb 12.
    Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
    The role of melanin in agents of chromoblastomycosis in vivo still remains unclear. In this study, we addressed the question in a BALB/c mice infection model by using an albino mutant, which generated from a melanized meristematic mutant of F. monophora. Read More

    Dermoscopy of chromoblastomycosis.
    Dermatol Pract Concept 2017 Oct 31;7(4):23-24. Epub 2017 Oct 31.
    Department of Dermatology and Venereology All India Institute of Medical Sciences, New Delhi, India.
    Chromoblastomycosis is a chronic cutaneous fungal infection commonly caused byand. Dermoscopy is a non-invasive, real-time diagnostic tool for rapid bedside diagnosis of various inflammatory and non-inflammatory disorders and can be an excellent modality for evaluation of cutaneous mycosis, for which it shows characteristic brown dots, crust, scales and yellow orange structures. Read More

    The Major Chromoblastomycosis Etiologic AgentActivates the NLRP3 Inflammasome.
    Front Immunol 2017 20;8:1572. Epub 2017 Nov 20.
    Laboratory of Applied Immunology, Department of Cellular Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
    is the main etiologic agent of chromoblastomycosis (CBM), one of the most prevalent subcutaneous mycosis in tropical and subtropical countries. CBM is a poorly characterized chronic infection that commonly starts after transcutaneous inoculation of conidia and saprophytic hyphae of. Recently, we have shown that unlike conidia, hyphae and muriform cells (the parasitic morphotype) ofpromotes an intense inflammatory response pattern, which comprises the production of an inflammasome-derived cytokine, IL-1β. Read More

    Successful treatment of chromoblastomycosis of 10-year duration due to Fonsecaea nubica.
    Mycoses 2017 Nov 25. Epub 2017 Nov 25.
    Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    We report a case of chromoblastomycosis due to the presence of large plaque and verrucous hyperplasia lesions on the left upper limb, with elbow abnormal activities, in a 56-year-old male. The diagnosis of chromoblastomycosis was based on gross and microscopic morphologies, histopathological examination and clinical manifestation. Molecular tools were applied to identifying the causative agent Fonsecaea nubica, which is rarely reported to be associated with chromoblastomycosis. Read More

    [Chromoblastomycosis: clinical and microbiological characteristics of a neglected disease].
    Rev Chilena Infectol 2017 Aug;34(4):404-407
    Laboratorio de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú.
    Chromoblastomycosis is a neglected and chronic fungal disease, mainly affects the subcutaneous tissue in limbs of people with occupational risk. Here, we report two cases of adult patients from tropical regions of northern Peru, affected with chronic erythematous scaly lesions and multiple blackheads, pain, itching and scarring in older areas of injury. Direct examination of the dermal scales showed typical of this disease fumagoides cells; Fonsecaea pedrosoi and Fonsecaea sp. Read More

    Biodiversity and human-pathogenicity ofand relatives in.
    Persoonia 2017 Jun 2;38:1-19. Epub 2016 Aug 2.
    Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, P.R. China.
    as defined by its type speciesis a genus of, and a member of the group known as 'black yeasts and relatives'.has been reported from mutilating human infections such as chromoblastomycosis, disseminated phaeohyphomycosis and mycetoma, while morphologically similar fungi are rather commonly isolated from the environment. Phenotypes are insufficient for correct species identification, and molecular data have revealed significant genetic variation within the complex of species currently identified asor. Read More

    Chromoblastomycosis in Taiwan: A report of 30 cases and a review of the literature.
    Med Mycol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taiwan.
    Chromoblastomycosis (CBM) is an implantation mycosis characterized by the presence of pigmented muriform cells in tissue. CBM is endemic in Taiwan, but only three formal cases have been reported to date because of underreporting. To describe and update its epidemiologic features, we report a series of 30 cases between 2003 and 2016 at a single medical center. Read More

    Comparative Genomics of Sibling Species ofAssociated with Human Chromoblastomycosis.
    Front Microbiol 2017 9;8:1924. Epub 2017 Oct 9.
    Microbiology, Parasitology and Pathology Post-Graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, Brazil.
    andare genera of black yeast-like fungi harboring agents of a mutilating implantation disease in humans, along with strictly environmental species. The current hypothesis suggests that those species reside in somewhat adverse microhabitats, and pathogenic siblings share virulence factors enabling survival in mammal tissue after coincidental inoculation driven by pathogenic adaptation. A comparative genomic analysis of environmental and pathogenic siblings ofandwas undertaken, includingassembly offrom plant material. Read More

    Chromoblastomycosis of the leg.
    Pol J Pathol 2017;68(2):182-184
    Case Report: We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Read More

    Photodynamic effects on Fonsecaea monophora conidia and RAW264.7 in vitro.
    J Photochem Photobiol B 2017 Nov 18;176:112-117. Epub 2017 Sep 18.
    Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, Guangzhou 510120, China. Electronic address:
    Chromoblastomycosis (CBM), one of the neglected tropical diseases, is hard to cure and easy to be recurrent. Many studies suggest that macrophage is involved in the pathogenesis of chromoblastomycosis and the fungicidal effect of 5-Aminolaevulinic Acid-Based Photodynamic Therapy (ALA-PDT) against F. monophora (one of the main causative agent of chromoblastomycosis) has shown great promise. Read More

    Chromoblastomycosis: tissue modifications during itraconazole treatment.
    An Bras Dermatol 2017 Jul-Aug;92(4):478-483
    Discipline of Biostatistics of the Medical School - Pontifícia Universidade Católica do Paraná (PUC-PR) - Curitiba (PR), Brazil.
    Background:: Histological and mycological changes during itraconazole use have not been totally established in chromoblastomycosis.

    Objectives:: To evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment.

    Methods:: A histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Read More

    Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar.
    J Mycol Med 2017 Sep 25;27(3):312-324. Epub 2017 Aug 25.
    Laboratoire de parasitologie-mycologie, CHU de Grenoble-Alpes, CS 10217, 38043 Grenoble cedex 9, France; Laboratoire TIMC-IMAG TheREx, université de Grenoble-Alpes, domaine de la Merci, 38706 La Tronche cedex, France. Electronic address:
    Chromoblastomycosis and sporotrichosis are endemic fungal infections of tropical and subtropical regions, including Madagascar. The causal fungi develop in the soil or on plants and infect humans through wounds, either directly (wounding by the plant, through thorns, for example), or through the contact of an existing wound with contaminated soil. For this reason, the lesions predominantly occur on the limbs, and these fungi principally infect people working outside with bare hands and/or feet. Read More

    Neglected endemic mycoses.
    Lancet Infect Dis 2017 Nov 31;17(11):e367-e377. Epub 2017 Jul 31.
    Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
    Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Read More

    Chromoblastomycosis in India: Review of 169 cases.
    PLoS Negl Trop Dis 2017 Aug 3;11(8):e0005534. Epub 2017 Aug 3.
    Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
    Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis is often delayed or misdirected either due to poor degree of clinical suspicions or clinical simulation of dermatological conditions. Read More

    Study on the organization of cellular elements in the granulomatous lesion caused by chromoblastomycosis.
    J Cutan Pathol 2017 Nov 30;44(11):915-918. Epub 2017 Aug 30.
    Graduate Program in Medicine: Department of Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
    Background: Chromoblastomycosis is a deep fungal infection characterized by a complex cellular granuloma. The aim of this study was to analyze the arrangement of cells responsible for the granuloma configuration of this disease by semiquantification of the cellular components of chromoblastomycosis skin biopsies.

    Methods: The cells of cutaneous biopsies slides from 100 patients with untreated chromoblastomycosis were stained with hematoxylin-eosin and the granuloma cells were evaluated by microscopic examination of the elements of each granuloma and semiquantified the number of cells through its expressivity in crosses and the histopathological variables. Read More

    Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.
    Int J Dermatol 2017 Oct 3;56(10):1037-1045. Epub 2017 Jul 3.
    Medicine School, Universidad Peruana Cayetano Heredia, Lima, Peru.
    Background: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs.

    Objectives: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses.

    Methods: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. Read More

    Respiratory Tract Infection Caused by Fonsecaea monophora After Kidney Transplantation.
    Mycopathologia 2017 Dec 28;182(11-12):1101-1109. Epub 2017 Jun 28.
    Clínica de Doenças Infecciosas e Parasitárias, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Justiniano da Rocha 201/302, Vila Isabel, Rio de Janeiro, RJ, CEP 20551-010, Brazil.
    Fonsecaea spp. are melanized fungi which cause most cases of chromoblastomycosis. The taxonomy of this genus has been revised, now encompassing four species, with different pathogenic potential: F. Read More

    HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events in.
    Front Microbiol 2017 19;8:918. Epub 2017 May 19.
    Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fundação Oswaldo CruzRio de Janeiro, Brazil.
    is the main etiological agent of chromoblastomycosis, a recalcitrant disease that is extremely difficult to treat. Therefore, new chemotherapeutics to combat this fungal infection are urgently needed. Although aspartic peptidase inhibitors (PIs) currently used in the treatment of human immunodeficiency virus (HIV) have shown anti-activity their exact mechanisms of action have not been elucidated. Read More

    High-resolution melting analysis assay for identification of Fonsecaea species.
    J Clin Lab Anal 2018 Feb 22;32(2). Epub 2017 May 22.
    Department of Dermatology and Venerology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Background: Chromoblastomycosis (CBM) is a chronic fungal disease. In China, the principle etiologic agent was a group of dematiaceous fungi, including Fonsecaea monophora, Fonsecaea nubica, and Cladophialophora carrionii. Although the Fonsecaea species have similar morphology, their pathogenicity is quite different. Read More

    Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review.
    Transpl Infect Dis 2017 Aug 26;19(4). Epub 2017 Jun 26.
    Department of Medicine, Division of Infectious Diseases, Jackson Health System/University of Miami Miller School of Medicine, Miami, FL, USA.
    This case report and literature review underscores the cutaneous presentations of phaeohyphomycosis in the solid organ transplant population. Increased cognizance with prompt identification is critical. The therapy and clinical outcomes of phaeohyphomycosis, caused by the Exophiala genus, in the solid organ transplant population, is analyzed to examine optimal care. Read More

    Chromoblastomycosis caused by: Case report.
    Med Mycol Case Rep 2017 Jun 7;16:25-27. Epub 2017 Apr 7.
    Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2400 - 2nd floor, Porto Alegre CEP: 90035-003, Brazil.
    We report a case of chromoblastomycosis in lesions on the chest and foot. Itraconazole was chosen as the initial treatment for this patient, who was followed up for 8 months before becoming noncompliant. The pathogenic fungal species was identified asby ITS region sequencing. Read More

    Unique case report of a chromomycosis and Listeria in soft tissue and cerebellar abscesses after kidney transplantation.
    BMC Infect Dis 2017 04 20;17(1):288. Epub 2017 Apr 20.
    Département d'Urologie, Néphrologie et Transplantation, AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix. 47-83, Bd de l'Hôpital, 75013, Paris, France.
    Background: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. Read More

    [Chromomycosis acquired in a non-tropical area: A case report].
    Ann Dermatol Venereol 2017 Jun - Jul;144(6-7):438-442. Epub 2017 Apr 7.
    Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:
    Background: Chromomycosis, or chromoblastomycosis, is caused by cutaneous inoculation of dematiaceous fungi of telluric or plant origin. It is generally seen in tropical or subtropical zones. Treatment of the condition is known to be complex. Read More

    Chromomycosis, an unusual cause of cicatricial ectropion: a case report.
    Arq Bras Oftalmol 2017 Jan-Feb;80(1):46-48
    Centro de Referência em Oftalmologia, Hospital de Clínica Médica, Universidade Federal de Goiás (UFG), Goiania, GO, Brazil.
    Chromomycosis is a fungal infection that affects the epidermis, dermis, and subcutaneous tissue and is caused by dematiaceous fungal species that turn black on staining. We report the case of a 50-year-old male patient who was a rural worker and had been treated without success for three decades. Facial lesions progressed and caused severe cicatricial retraction. Read More

    Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity.
    PLoS Negl Trop Dis 2017 Mar 29;11(3):e0005461. Epub 2017 Mar 29.
    Department of Cell Biology, Institute of Biological Sciences; University of Brasília, Brasília, Brazil.
    A common theme across multiple fungal pathogens is their ability to impair the establishment of a protective immune response. Although early inflammation is beneficial in containing the infection, an uncontrolled inflammatory response is detrimental and may eventually oppose disease eradication. Chromoblastomycosis (CBM), a cutaneous and subcutaneous mycosis, caused by dematiaceous fungi, is capable of inducing a chronic inflammatory response. Read More

    Exploring the genomic diversity of black yeasts and relatives (,).
    Stud Mycol 2017 Mar 27;86:1-28. Epub 2017 Jan 27.
    Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands; Department of Basic Pathology, Federal University of Paraná State, Curitiba, PR, Brazi1; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
    The order(,) harbours obligatorily melanised fungi and includes numerous etiologic agents of chromoblastomycosis, phaeohyphomycosis and other diseases of vertebrate hosts. Diseases range from mild cutaneous to fatal cerebral or disseminated infections and affect humans and cold-blooded animals globally. In addition,comprise species with aquatic, rock-inhabiting, ant-associated, and mycoparasitic life-styles, as well as species that tolerate toxic compounds, suggesting a high degree of versatile extremotolerance. Read More

    Mycetoma-like chromoblastomycosis: a diagnostic dilemma.
    Int J Dermatol 2017 May 23;56(5):563-566. Epub 2017 Feb 23.
    Department of Dermatology and Venereology, Government Medical College, Kottayam, Kerala, India.
    Objectives: Mycetoma and chromoblastomycosis are subcutaneous fungal infections caused by pigmented fungi, common in the tropics and subtropics. Here we report a pregnant woman who presented with a swelling around the ankle joint which was clinically diagnosed as a case of mycetoma; however, further investigations revealed it to be a case of chromoblastomycosis.

    Methods: 24 year old primigravida presented with an indurated swelling around the ankle joint with multiple nodules and sinuses draining serosanguinous discharge. Read More

    1,10-Phenanthroline-5,6-Dione-Based Compounds Are Effective in Disturbing Crucial Physiological Events of.
    Front Microbiol 2017 30;8:76. Epub 2017 Jan 30.
    Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz Rio de Janeiro, Brazil.
    is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. Read More

    [Cancer and mycoses and literature review].
    Bull Soc Pathol Exot 2017 Feb 11;110(1):80-84. Epub 2017 Feb 11.
    Service de parasitologie-mycologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.
    Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Read More

    Phylogenomic analyses reveal the diversity of laccase-coding genes in Fonsecaea genomes.
    PLoS One 2017 10;12(2):e0171291. Epub 2017 Feb 10.
    CBS-KNAW Fungal Biodiversity Centre, Utrecht, Netherlands.
    The genus Fonsecaea comprises black yeast-like fungi of clinical relevance, including etiologic agents of chromoblastomycosis and cerebral phaeohyphomycosis. Presence of melanin and assimilation of monoaromatic hydrocarbons and alkylbenzenes have been proposed as virulence factors. Multicopper oxidase (MCO) is a family of enzymes including laccases, ferroxidases and ascorbate oxidases which are able to catalyze the oxidation of various aromatic organic compounds with the reduction of molecular oxygen to water. Read More

    Severe Chromoblastomycosis-Like Cutaneous Infection Caused by.
    Front Microbiol 2017 25;8:83. Epub 2017 Jan 25.
    Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical UniversityShanghai, China; Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, Second Military Medical UniversityShanghai, China; Department of Dermatology, First Hospital of Xinjiang Medical UniversityUrumqi, China.
    species are saprophytic filamentous fungi commonly found in the soil, dung, and animal fur. Subcutaneous infection caused by this organism is rare in humans. We report a case of subcutaneous fungal infection caused byin a 38-year-old woman. Read More

    Melanized fungal infections in kidney transplant recipients: contributions to optimize clinical management.
    Clin Microbiol Infect 2017 May 3;23(5):333.e9-333.e14. Epub 2017 Jan 3.
    Special Mycology Laboratory-LEMI, Division of Infectious Diseases, Federal University of São Paulo, São Paulo, SP, Brazil; Division of Infectious Diseases, Federal University of São Paulo, São Paulo, SP, Brazil. Electronic address:
    Objectives: This is a retrospective and observational study addressing clinical and therapeutic aspects of melanized fungal infections in kidney transplant recipients.

    Methods: We retrospectively reviewed medical records of all patients admitted between January 1996 and December 2013 in a single institution who developed infections by melanized fungi.

    Results: We reported on 56 patients aged between 30 and 74 years with phaeohyphomycosis or chromoblastomycosis (0. Read More

    Molecular identification of chromoblastomycosis clinical isolates in Guangdong.
    Med Mycol 2017 Nov;55(8):851-858
    Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue. The most common etiologic agent encountered in Southern China is from the genus Fonsecaea. Fonsecaea species are often misidentified due to indistinct morphology features; furthermore, recent taxonomy revision was done on the fungi genus. Read More

    Wide Morphologic Variability of Chromoblastomycosis in the Western Hemisphere.
    Skinmed 2016 1;14(6):423-427. Epub 2016 Dec 1.
    Department of Dermatology, Baylor College of Medicine, Houston, TX.
    Chromomycosis is an uncommon fungal disease seen in tropical and subtropical regions of the world. The disorder is most likely the result of traumatic percutaneous inoculation of one of several etiologic dematiaceous fungi. Causative organisms have been associated with dead wood, soil, and plants. Read More

    Galectin-3 Expression in Benign and Malignant Skin Diseases With Epidermal Hyperplasia.
    Am J Dermatopathol 2017 Oct;39(10):738-741
    Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6. Read More

    Verrucous Onychomycosis Caused byin a Patient with Congenital Pterygium.
    Indian J Dermatol 2016 Nov-Dec;61(6):701
    Department of Pathology, Government Medical College, Kottayam, Kerala, India.
    A 57 year healthy farmer with congenital nail pterygium presented with a verrucous growth on nail bed since 8 months. He was not diabetic and HIV rapid card test negative. Our clinical diagnosis was chromoblastomycosis but culture showed growth of curvularia species on two occasions and histopathology showed hyphal and yeast forms of the pigmented fungus. Read More

    Two Cases of Chromomycosis Identified by Molecular Phylogenetic Analysis.
    Med Mycol J 2016 ;57(4):J133-J139
    Department of Dermatology, Kyorin University School of Medicine.
    Chromomycosis is an infection caused by dematiaceous fungi. These fungi belong to several genera with varied clinical presentations and parasitic forms. The disease is roughly classified into three types: chromoblastomycosis, black-grain mycetoma, and phaeohyphomycosis. Read More

    Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species.
    PLoS Negl Trop Dis 2016 Nov 28;10(11):e0005102. Epub 2016 Nov 28.
    Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil.
    The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin genes. Strains studied were limited to three clusters divided over the single family Herpotrichiellaceae known to comprise agents of the disease. Read More

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