Search Our Scientific Publications & Authors

Pediatr Neurosurg 2022 Jun 27. Epub 2022 Jun 27.

Introduction: Choroid plexus tumors are rare neuroectodermal tumors that arise from the choroid plexus. Choroid plexus papillomas (CPP) represent the lowest grade of these types of tumors and have a WHO grade I designation. Despite their typical low grade, some CPPs can exhibit aggressive behaviors including parenchymal invasion and dissemination throughout the neuro-axis. Read More

Cureus 2022 May 23;14(5):e25256. Epub 2022 May 23.

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Institute, Los Angeles, USA.

Atypical choroid plexus papilloma (aCPP) is very rarely seen in adults. Here, we present the case of a 47-year-old male with several months of headache, nausea, dizziness, and imbalance who was found to have an enhancing mass of the fourth ventricle with imaging findings suggestive of likely ependymoma. The patient underwent suboccipital craniotomy with C1 laminectomy and telovelar approach for gross-total resection of the lesion, with final pathology demonstrating WHO grade II aCPP. Read More

Indian J Radiol Imaging 2022 Mar 19;32(1):71-80. Epub 2022 Apr 19.

Department of Neurosurgery, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.

There are many types of neoplasms in or around the foramen of Luschka (FL), and definitive diagnosis in some cases requires knowledge of imaging findings. The uncommon and challenging neoplasms with FL involvement considered in this study are exophytic brainstem glioma, primary glioblastoma of the cerebellopontine angle (CPA), primary anaplastic ependymoma of the CPA, choroid plexus papilloma of the FL, solitary FL choroid plexus metastasis, extraskeletal myxoid chondrosarcoma of the jugular foramen, paraganglioma of the jugular foramen, exostosis of the jugular foramen, psammomatous meningioma in the lateral cerebellar medullary cistern, epidermoid tumor of the fourth ventricle, and a hypoglossal schwannoma. These neoplasms may have overlapping clinical and imaging features, but some have relatively distinct imaging features. Read More

Cureus 2022 May 10;14(5):e24892. Epub 2022 May 10.

Consultant Neurosurgery, King Abdulaziz Medical City, Ministry of National Guards Health Affairs, Jeddah, SAU.

Choroid plexus papilloma (CPP) is a rare intraventricular tumor. The common locations of the tumor vary based on the age of the patient. It usually occurs in the supratentorial region in children, however in adult patients, these tumors commonly present in the infratentorial region. Read More

iScience 2022 Jun 10;25(6):104383. Epub 2022 May 10.

Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

The choroid plexus (CP) is a highly vascularized structure containing endothelial and epithelial cells located in the ventricular system of the central nervous system (CNS). The role of the fenestrated CP endothelium is under-researched and requires the generation of an immortalized CP endothelial cell line with preserved features. Transduction of primary human CP endothelial cells (HCPEnC) with the human telomerase reverse transcriptase (hTERT) resulted in immortalized HCPEnC (iHCPEnC), which grew as monolayer with contact inhibition, formed capillary-like tubes in Matrigel, and showed no colony growth in soft agar. Read More

Front Pediatr 2022 26;10:870951. Epub 2022 Apr 26.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors.

Materials And Methods: We analyzed the clinical data comprising of 35 cases of GPST from a single center between January 2015 and December 2020. The tumor volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):416-419

Department of Brain Surgery, Başkent University, Adana, Turkey.

Childhood orbital teratomas are usually congenital lesions that are most often present at birth with progressive, massive unilateral proptosis. During the routine controls of 27-year-old woman between 26-27 weeks of pregnancy her fetal ultrasonography (USG) revealed a mass in the eye of the fetus, and termination was recommended. The family refused the termination option and in the 37 week of pregnancy, vaginal delivery is performed in an external medical center. Read More

Cell Death Differ 2022 Mar 23. Epub 2022 Mar 23.

Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, NY, 11568, USA.

Multiciliated cells (MCCs) in the brain reside in the ependyma and the choroid plexus (CP) epithelia. The CP secretes cerebrospinal fluid that circulates within the ventricular system, driven by ependymal cilia movement. Tumors of the CP are rare primary brain neoplasms mostly found in children. Read More

World Neurosurg 2022 Jun 18;162:74-76. Epub 2022 Mar 18.

Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Infantile choroid plexus papilloma (CPP) associated with multiple peritumoral cysts is a rare variant of CPP, and clinical course and optimal management are largely unknown. A 9-month-old boy presented with a large solid tumor in the left lateral ventricle associated with multiple peritumoral cysts, arachnoid cysts, and hydrocephalus containing xanthochromic fluid with high protein content. Shrinkage of these cysts and resolution of hydrocephalus were achieved after total resection of the hypervascular solid part of the tumor. Read More

iScience 2022 Apr 1;25(4):104014. Epub 2022 Mar 1.

Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.

is the causative agent of human African trypanosomiasis. The parasite transmigrates from blood vessels across the choroid plexus epithelium to enter the central nervous system, a process that leads to the manifestation of second stage sleeping sickness. Using an model of the blood-cerebrospinal fluid barrier, we investigated the mechanism of the transmigration process. Read More

Int J Mol Sci 2022 Feb 23;23(5). Epub 2022 Feb 23.

CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.

The choroid plexuses (CPs), located in the brain ventricles, form an interface between the blood and the cerebrospinal fluid named the blood-cerebrospinal barrier, which, by the presence of tight junctions, detoxification enzymes, and membrane transporters, limits the traffic of molecules into the central nervous system. It has already been shown that sex hormones regulate several CP functions, including the oscillations of its clock genes. However, it is less explored how the circadian rhythm regulates CP functions. Read More

J Neuroophthalmol 2022 Feb 25. Epub 2022 Feb 25.

Baylor College of Medicine (SPW), Houston, Texas; Department of Ophthalmology (SR, PWM), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), Bryan, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

J Pediatr Hematol Oncol 2022 05 18;44(4):e844-e848. Epub 2022 Feb 18.

Departments of Hematology/Oncology.

An underestimation of pathologic diagnosis could be expected if disseminated choroid plexus tumors (CPTs) are diagnosed as lower grade tumors. Thus, molecular diagnosis using genome-wide DNA methylation profiling may be useful for clarifying the malignant potential of the tumor entity. Herein, we report a 2. Read More

NMC Case Rep J 2021 23;8(1):727-731. Epub 2021 Oct 23.

Department of Neurosurgery, Pasia Garden Clinic, Niigata, Niigata, Japan.

We report for the first time a case of choroid plexus papilloma (CPP) of the fourth ventricle associated with adrenal pheochromocytoma. A large tumor was found in the fourth ventricle of a 24-year-old man who presented with symptoms of increased intracranial pressure due to obstructive hydrocephalus. A systemic search revealed that the patient also had an asymptomatic left adrenal tumor. Read More

J Neurooncol 2022 Feb 8;156(3):599-613. Epub 2022 Jan 8.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany.

Introduction: Standards for chemotherapy against choroid plexus tumors (CPT) have not yet been established.

Methods: CPT-SIOP-2000 (NCT00500890) was an international registry for all CPT nesting a chemotherapy randomization for high-risk CPT with Carboplatin/Etoposide/Vincristine (CarbEV) versus Cyclophosphamide/Etoposide/Vincristine (CycEV). Patients older than three years were recommended to receive irradiation: focal fields for non-metastatic CPC, incompletely resected atypical choroid plexus papilloma (APP) or metastatic choroid plexus papilloma (CPP); craniospinal fields for metastatic CPC/APP and non-responsive CPC. Read More

Neurol India 2021 Nov-Dec;69(6):1890-1892

Department of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Radiol Case Rep 2022 Mar 15;17(3):502-504. Epub 2021 Dec 15.

Department of Neurosurgery, Viet Duc Hospital, Hanoi, Vietnam, Minh City, Vietnam.

Choroid plexus papillomas (CPPs) are uncommon, benign intracranial tumors that can occur in both children and adults. In adults, CPPs are typically identified in the fourth ventricle, whereas in children, they most commonly occur in the lateral ventricle. CPPs that arise from the extraventricular system are extremely rare and difficult to diagnose. Read More

BMC Infect Dis 2021 Dec 20;21(1):1276. Epub 2021 Dec 20.

Department of Oncology, The Seventh People's Hospital of Hebei Province, No. 389, Jungong Road, Dingzhou, 073000, Hebei, People's Republic of China.

Background: While Ureaplasma parvum has previously been linked to the incidence of chorioamnionitis, abortion, premature birth, and perinatal complications, there have only been rare reports of invasive infections of the central nervous system (CNS) in adults. Owing to its atypical presentation and the fact that it will yield sterile cultures using conventional techniques, diagnosing U. parvum meningitis can be challenging. Read More

Fluids Barriers CNS 2021 Dec 4;18(1):53. Epub 2021 Dec 4.

Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Background: The Gram-negative bacterium Neisseria meningitidis (Nm) can cause meningitis in humans, but the host signalling pathways manipulated by Nm during central nervous system (CNS) entry are not completely understood.

Methods: We investigate the role of the mitogen-activated protein kinases (MAPK) Erk1/2 and p38 in an in vitro model of the blood-cerebrospinal fluid barrier (BCSFB) based on human epithelial choroid plexus (CP) papilloma (HIBCPP) cells during infection with Nm serogroup B (NmB) and serogroup C (NmC) strains. A transcriptome analysis of HIBCPP cells following infection with Nm by massive analysis of cDNA ends (MACE) was done to further characterize the cellular response to infection of the barrier. Read More

Turk Neurosurg 2022 ;32(3):508-512

Ankara University, School of Medicine, Department of Neurosurgery, Ankara, Turkey.

Aim: To report the first case of an isolated lumbar grade II atypical choroid plexus papilloma (CPP).

Case Report: A 42-year-old man was admitted to the hospital because of back and leg pain. No urinary or rectal dysfunction was detected. Read More

World Neurosurg 2021 Nov 22. Epub 2021 Nov 22.

Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.

Objective: To present long-term follow-up of a consecutive single-institutional series of patients treated for choroid plexus tumors over 8 decades.

Methods: From 1939 to 2020, 59 children were treated for choroid plexus tumors. Median age at diagnosis was 1. Read More

Clin Imaging 2022 Feb 29;82:38-52. Epub 2021 Oct 29.

Sengkang General Hospital, Department of Radiology, 110, Sengkang Eastway, 544886, Singapore; Duke-NUS Medical School, 8 College Rd, 169857, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:

Primary intraventricular neoplasms are rare tumors that originate from the ependymal or subependymal, septum pellucidum, choroid plexus and the supporting arachnoid tissue. Knowledge of the common locations of these tumors within the ventricular system, together with key imaging characteristics and presentation age, can significantly narrow the differential diagnosis. In 2016, the WHO reorganized the classification of several primary CNS tumors by combining histopathological and molecular data. Read More

Curr Health Sci J 2021 Apr-Jun;47(2):310-313. Epub 2021 Jun 30.

Clinic of Radiology, University Clinical Center of Kosovo, Kosovo.

Aim: Choroid plexus papilloma (CPP) according to the latest WHO classification system in 2016 are an uncommon, benign (WHO grade I) neuroepithelial intraventricular tumor derived from choroid plexus epithelium, which can occur in both the pediatric and adult population. These tumors account for approximately 1% of all brain tumor 2-6% of pediatric brain tumors and 0.5% of adult brain tumors. Read More

Surg Neurol Int 2021 30;12:483. Epub 2021 Sep 30.

Department of Pathology, King Saud University, Riyadh, Saudi Arabia.

Background: Hydrocephalus is the most common presentation of choroid plexus tumors; it is thought to be caused either by mass effect obstructing the cerebrospinal fluid pathways or secretory properties of the tumor. In these case reports, we present two cases of choroid plexus tumors with persistence of communicating hydrocephalus postoperatively and review similar reports in the literature.

Case Description: Case 1: a 2-month-old baby girl presented with bulging fontanelle, sunsetting eyes. Read More

Surg Neurol Int 2021 6;12:444. Epub 2021 Sep 6.

Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, United States.

Background: Choroid plexus papilloma represents 1-4% of pediatric brain tumors, mostly located in the ventricular atrium.[1] Intraventricular tumors represent a challenge due to the poor visualization of the surgical field and damage to surrounding structures.[2] Use of tubular retraction reduces cerebrovascular trauma to the surrounding parenchyma by distributing pressure uniformly, allowing less invasive corticotomy, and more stability on surgical corridors that allow the surgeon to use both hands and external visualization devices. Read More

Asian J Surg 2022 Jan 12;45(1):544-545. Epub 2021 Oct 12.

Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China. Electronic address:

JFMS Open Rep 2021 Jul-Dec;7(2):20551169211048464. Epub 2021 Oct 6.

Neurology and Neurosurgery Department, Fitzpatrick Referrals Orthopaedics and Neurology, Eashing, UK.

Case Summary: A 10-year-old male neutered Russian Blue cat was presented with a 2-month history of progressive non-ambulatory paraparesis. Spinal MRI revealed a well-demarcated, compressive intradural extramedullary mass at the level of T1 vertebra. The mass had subtle hyperintensity on T2-weighted images, was isointense on T1-weighted images and had diffuse, marked enhancement following gadolinium administration. Read More

J Neurooncol 2021 Oct 16;155(1):63-70. Epub 2021 Sep 16.

Division of Paediatric Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Introduction: Choroid Plexus Tumours (CPTs) account for 1-4% of all brain tumours in children. Atypical choroid plexus papillomas (aCPPs) are a subset of these tumours, defined over a decade ago, yet no consensus exists on the optimal approach to their management.

Methods: We conducted a retrospective analysis of all patients treated for CPTs at the Hospital for Sick Children between January 1, 2000, and December 31, 2018, and focused on patients with aCPP. Read More

Pathog Dis 2021 09;79(7)

Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.

Neisseria meningitis (Nm) is a human-specific bacterial pathogen that can cause sepsis and meningitis. To cause meningitis Nm must enter the central nervous system (CNS) across one of the barriers between the blood and the brain. We have previously shown that a capsule-depleted Serogroup B strain of Nm displays enhanced invasion into human choroid plexus (CP) epithelial papilloma (HIBCPP) cells, which represent an in vitro model of the blood-cerebrospinal fluid barrier (BCSFB). Read More

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748 Olsztyn, Poland.

Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by β-glucuronidase (β-Gluc) to Q aglycone, which easily enters the brain. This study evaluates the effect of lipopolysaccharide (LPS)-induced acute inflammation on β-Gluc gene expression in the choroid plexus (ChP) and its activity in blood plasma, ChP and cerebrospinal fluid (CSF), and the concentration of Q and its phase II metabolites in blood plasma and CSF. Studies were performed on saline- and LPS-treated adult ewes ( = 40) receiving Q3GA intravenously ( = 16) and on primary rat ChP epithelial cells and human ChP epithelial papilloma cells. Read More