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Int J Clin Exp Pathol 2021 15;14(4):545-550. Epub 2021 Apr 15.

Department of Pathology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University Seoul, Republic of Korea.

A 42-year-old male presented with a history of headaches for the previous 2 weeks. Magnetic resonance imaging of the brain showed a 3 cm-sized well-defined, enhancing mass in the atrium of the right lateral ventricle. The tumor comprised two heterogeneous components: approximately one-third of the tumor exhibited complex and delicate papillary fibrovascular cores lined with uniform cuboidal-to-columnar epithelial cells, whereas the remaining part was seen as a solid sheet comprising ovoid-to-spindle cells with plump cytoplasm, which occasionally had a whorling pattern. Read More

World Neurosurg 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Choroid plexus carcinoma is a central nervous system tumor pathologically corresponding to World Health Organization grade III. Choroid plexus carcinoma mainly affects pediatric patients with a poor prognosis. Due to its rarity, the standardized treatment has not yet been outlined. Read More

J Clin Neurol Neurosci 2021 2;2. Epub 2021 Apr 2.

Department of Neurosurgery, University of Florida College of Medicine, Gainesville, USA.

Atypical choroid plexus papilloma is a rare pediatric brain tumor that has distinct clinical and pathologic features. In this case, we highlight the diagnosis and management of this rare disease. The details of case positioning and execution are discussed. Read More

Neurosurg Rev 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurosurgery, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Cureus 2021 Mar 6;13(3):e13737. Epub 2021 Mar 6.

Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.

We present a rare prenatal diagnosis of bilateral choroid plexus papillomas by obstetrical ultrasound and fetal MRI at 20 weeks 6 days gestation. The fetus demonstrated bilateral enlarged, echogenic choroid plexus with increased Doppler flow suggestive of vascularized choroid tissue. Same-day fetal MRI demonstrated that the choroid plexus appeared enlarged bilaterally without definite hemorrhage. Read More

Clin Ter 2021 Mar;172(2):99-103

Department of Radiology, Hanoi Medical University, Ha Noi, Vietnam.

Abstract: Choroid plexus papilloma (CPP), a low incidence central nervous system (CNS) tumor, typically develops as an intraventricular neoplasm arising from the epithelium of the choroid plexus. Infratentorial CPP is predominantly clustered in adults with roughly 70% in the fourth ventricle, while supratentorial CPP commonly found in the lateral ventricles, is the most frequent location in children. The clinical and imaging features of CPP are not typical and may induce the misdiagnosis as other types of primary brain tumors. Read More

Front Cell Infect Microbiol 2021 8;11:639620. Epub 2021 Mar 8.

Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

() is an important opportunistic pathogen, which can cause septicemia and meningitis in pigs and humans. Previous observations in -infected pigs revealed lesions at the choroid plexus (CP). experiments with primary porcine CP epithelial cells (PCPEC) and human CP epithelial papilloma (HIBCPP) cells demonstrated that can invade and traverse the CP epithelium, and that the CP contributes to the inflammatory response cytokine expression. Read More

Neurosurg Rev 2021 Feb 24. Epub 2021 Feb 24.

Department of Neurosurgery, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Choroid plexus papillomas (CPPs) are primary neuroectodermal neoplasms that usually arise in the fourth ventricle in adults. In this study, we present 12 patients with CPP arising from the cerebellopontine angle (CPP-CPA) and/or of the cerebellomedullary angle (CPP-CMA) that were treated in our department. Patients who underwent surgery for the treatment for CPP-CPA/CMA from January 2004 to March 2020 were identified by a computer search of their files from the Department of Neurosurgery, Tübingen. Read More

Cold Spring Harb Mol Case Stud 2021 Feb 19;7(1). Epub 2021 Feb 19.

Department of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.

Choroid plexus tumors are rare pediatric neoplasms ranging from low-grade papillomas to overtly malignant carcinomas. They are commonly associated with Li-Fraumeni syndrome and germline mutations. Choroid plexus carcinomas associated with Li-Fraumeni syndrome are less responsive to chemotherapy, and there is a need to avoid radiation therapy leading to poorer outcomes and survival. Read More

Front Immunol 2020 26;11:618544. Epub 2021 Jan 26.

Molecular Neuroimmunology Group, Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany.

The role of B cells in multiple sclerosis (MS) is increasingly recognized. B cells undergo compartmentalized redistribution in blood and cerebrospinal fluid (CSF) during active MS, whereby memory B cells accumulate in the CSF. While B-cell trafficking across the blood-brain barrier has been intensely investigated, cellular diapedesis through the blood-CSF barrier (BCSFB) is incompletely understood. Read More

Curr Oncol 2021 Jan 31;28(1):750-756. Epub 2021 Jan 31.

Radiation Oncology Division, The Ottawa Hospital-University of Ottawa, Ottawa, ON K1H 8L6, Canada.

Choroid plexus papilloma (CPP) is a rare brain tumour occurring mostly in infants and children. Most CPPs are intraventricular and present with symptoms and signs of increased intracranial pressure (ICP). This case report describes a middle-aged female who presented with spontaneous cerebrospinal fluid (CSF) rhinorrhea from a tumour located in the cerebellopontine angle (CPA). Read More

J Pediatr Neurosci 2020 Jul-Sep;15(3):338-340. Epub 2020 Nov 6.

Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Orissa, India.

Endocr Pract 2020 Oct;26(10):1105-1114

From the Pediatric Endocrinology and Diabetes Unit, Tel-Aviv, Israel.

Objective: To explore incidental findings on brain magnetic resonance imaging (MRI) studies of pediatric patients referred due to endocrine disorders.

Methods: A retrospective, observational study conducted in a tertiary referral center. The neuroimaging database of 17,445 brain MRI studies of 11,011 pediatric patients were searched for cases with endocrine referrals and without medical history of malignancy, genetic syndromes, and/or neurologic comorbidities. Read More

Clin Neurol Neurosurg 2021 Feb 6;201:106454. Epub 2021 Jan 6.

Department of Neurosurgery, NIMHANS, Bangalore, India.

Objective: Choroid plexus tumours (CPT) are rare intraventricular tumours representing less than 0.5 % of brain tumours. The tumour is commonly located in the supratentorial region, but the location varies depending on the age. Read More

Hered Cancer Clin Pract 2021 Jan 6;19(1). Epub 2021 Jan 6.

Laboratory of Molecular Oncology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.

Background: Li-Fraumeni Syndrome (LFS) is a cancer predisposition syndrome characterized by the early-onset of multiple primary cancers which can occur at different moments (metachronous onset) or, more rarely, coincidentally (synchronous onset). Here we describe a previously unreported patient with presentation of synchronous Wilms tumor and Choroid plexus papilloma, leading to the diagnosis of a Li-Fraumeni Syndrome (LFS).

Case Presentation: A 6-year-old girl without previous complains presented with abdominal pain. Read More

Surg Neurol Int 2020 25;11:409. Epub 2020 Nov 25.

Department of Neurosurgery, Hospital Central Sur de Alta Especialidad PEMEX, Tlalpan, Ciudad de Mexico, Mexico.

Background: Choroid plexus papillomas (CPPs) are benign extra-axial tumors that originate from the choroid plexus; these tumors rarely have metastases, being at the spinal level the location with few reported cases.

Case Description: We report the case of a 48-year-old man with a history of atypical fourth ventricular CPP and gross total resection (GTR) in 2008. In 2015, he presented with radicular pain, decreased strength, and paresthesia in the left leg. Read More

Microorganisms 2020 Dec 10;8(12). Epub 2020 Dec 10.

Pediatric Infectious Diseases, University Children's Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Echovirus-30 (E-30) is a non-polio enterovirus responsible for meningitis outbreaks in children worldwide. To gain access to the central nervous system (CNS), E-30 first has to cross the blood-brain barrier (BBB) or the blood-cerebrospinal fluid barrier (BCSFB). E-30 may use lipid rafts of the host cells to interact with and to invade the BCSFB. Read More

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa139. Epub 2020 Oct 25.

Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Atypical choroid plexus papilloma is a recently introduced entity with intermediate pathological characteristics. These tumors are relatively rare and the optimal management of these tumors is a matter of debate. Therefore, we performed a systematic review and pooled analysis about the effects of adjuvant therapies on outcome measures of these patients. Read More

Neuro Oncol 2021 Apr;23(4):650-660

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

Background: Choroid plexus tumors (CPTs) are intraventricular brain tumors predominantly arising in children but also affecting adults. In most cases, driver mutations have not been identified, although there are reports of frequent chromosome-wide copy-number alterations and TP53 mutations, especially in choroid plexus carcinomas (CPCs).

Methods: DNA methylation profiling and RNA-sequencing was performed in a series of 47 CPTs. Read More

Clin Neurol Neurosurg 2021 01 4;200:106345. Epub 2020 Nov 4.

Department of Pediatric Neurosurgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. Electronic address:

Objective: Atypical choroid plexus papilloma (aCPP) is a newly introduced subtype of choroid plexus tumors (CPTs) defined by the World Health Organization (WHO) in 2007 and is characterized by intermediate characteristics between choroid plexus papilloma (CPP) and choroid plexus carcinoma (CPC). Currently, the available data describing the clinical features of aCPP in children are limited.

Methods: We performed a retrospective review of 24 pediatric patients with CPTs in our institute and focused on the clinical, radiological and histopathological features of 9 patients with aCPP. Read More

Front Vet Sci 2020 29;7:536. Epub 2020 Sep 29.

National Institute of Clinical Neurosciences, Budapest, Hungary.

A 6-years-old female Staffordshire terrier was referred for periodic generalized seizures and asymmetric visual deficits. Magnetic resonance imaging revealed a 23.2 × 19. Read More

Turk J Pediatr 2020 ;62(5):863-867

Departments of Neurosurgery, University of Health Sciences Ankara Health Research and Application Center, Ankara, Turkey.

Background: Ascites is defined as abnormal fluid retention in the peritoneal cavity and it can be encountered at any age including fetal life. Ascites mostly results from cirrhosis, chronic renal disease and heart failure in childhood. However, there are various reasons for cirrhotic and non-cirrhotic ascites in the pediatric age. Read More

Radiother Oncol 2021 01 8;154:220-226. Epub 2020 Oct 8.

National Cancer Institute, Cairo University, Egypt.

Purpose: Although the radiotherapy utilization rate (RUR) is determined for most adult cancers, it is seldom reported in childhood tumors, particularly in low- and middle-income countries (LMIC) where the majority of pediatric cancer patients reside. This study aims to investigate the real-life RUR for pediatric tumors in a large LMIC center.

Materials And Methods: The electronic files of patients treated at a single institution during 2010-2017 were reviewed and the RUR was defined as the percentage of patients who received at least one radiotherapy (RT) course from the total number of patients. Read More

Childs Nerv Syst 2021 Mar 26;37(3):799-807. Epub 2020 Sep 26.

Division of Neurosurgery, Department of Neurosciences, University of the Philippines - Philippine General Hospital, Manila, Philippines.

Introduction: Choroid plexus tumors are uncommon intraventricular tumors that develop from the choroid plexus of the central nervous system. Choroid plexus papillomas arising from the cerebellopontine angle have been reported to almost exclusively occur in adults and are rarely found in children.

Methods: We report a systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines of SCOPUS and PubMed databases for case reports and case series of choroid plexus papillomas arising in the cerebellopontine angle in the pediatric population and discuss clinical presentation, imaging features, management options, and outcomes. Read More

Medicine (Baltimore) 2020 Sep;99(38):e22062

University of Chicago, Department of Neurology, Chicago, IL.

Rationale: Primary central nervous system lymphoma (PCNSL) involving the choroid plexus is exceedingly rare. The differential diagnosis for choroid plexus enhancing lesions in addition to lymphoma includes infections, sarcoidosis, tuberculosis, papilloma, meningioma, subependymoma, and metastatic lesions.

Patient Concerns: A 71-year-old man presented with 3 days of episodic memory loss and gait disturbance. Read More

Cureus 2020 Aug 6;12(8):e9582. Epub 2020 Aug 6.

Neuroradiology Section, Neuroscience Institute, Hamad Medical Corporation, Doha, QAT.

Colloid cysts are the commonest masses of the third ventricle. Third ventricle neoplasms are uncommon. They include tumors arising from the choroid plexus (papillomas, carcinomas), tumors arising from other than the choroid plexus (ependymomas, meningiomas), metastases, and lymphoma. Read More

J Neurooncol 2020 Sep 8;149(2):283-292. Epub 2020 Sep 8.

Department of Radiation Oncology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.

Introduction: Choroid plexus tumors (CPTs) represent one of the most common intraventricular tumors. Although most are benign, they often reach considerable sizes before clinical manifestation, challenging their surgical management. We aim to describe the clinical characteristics and the impact of current management on the survival of patients harboring intraventricular CPT. Read More

Int J Mol Sci 2020 Aug 29;21(17). Epub 2020 Aug 29.

Pediatric Infectious Diseases, University Children's Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Echovirus-30 (E-30) is responsible for the extensive global outbreaks of meningitis in children. To gain access to the central nervous system, E-30 first has to cross the epithelial blood-cerebrospinal fluid barrier. Several meningitis causing bacteria preferentially infect human choroid plexus papilloma (HIBCPP) cells in a polar fashion from the basolateral cell side. Read More

Brain Sci 2020 Aug 8;10(8). Epub 2020 Aug 8.

Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85721, USA.

The blood-cerebrospinal fluid barrier (BCB) is important in maintaining brain manganese (Mn) homeostasis. This barrier consists of a single layer of epithelial cells, connected by tight junctions, that restrict the passage of nutrients to only allow molecules to be carried through the membrane by a transporter. These epithelial cells are polarized with asymmetrical blood-facing and cerebrospinal fluid-facing sides. Read More

BMC Pediatr 2020 07 7;20(1):336. Epub 2020 Jul 7.

Department of Pediatrics, Pusan National University School of Medicine, 20 Geumo-ro, Yangsan, 50612, Republic of Korea.

Background: Choroid plexus papillomas (CPPs) are rare, usually benign, neoplasms originating in the central nervous system. In this study, we present the first case of a giant airway-obstructing CPP in the pharynx of a newborn.

Case Presentation: A cystic mass located in the pharynx was noted in a fetus at the 29th week of gestation. Read More