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Childs Nerv Syst 2019 Apr 5. Epub 2019 Apr 5.

Rady Children's Hospital San Diego, San Diego, CA, USA.

Introduction: The object of this review is to describe the choroid plexus tumors (CPTs) occurring in the fetus and neonate with regard to clinical presentation, location, pathology, treatment, and outcome.

Materials And Methods: Case histories and clinical outcomes were reviewed from 93 cases of fetal and neonatal tumors obtained from the literature and our own institutional experience from 1980 to 2016.

Results: Choroid plexus papilloma (CPP) is the most common tumor followed by choroid plexus carcinoma (CPC) and atypical choroid plexus papilloma (ACPP). Read More

Asian J Neurosurg 2019 Jan-Mar;14(1):223-226

Department of Pathology, IPGME and R, Kolkata, West Bengal, India.

Papillary ependymoma is a rare variant of ependymoma. It has been included in Grade II tumors of updated 2016 WHO classification of central nervous system tumors. Only a handful of cases of spinal papillary ependymomas have been reported so far. Read More

J Neurosurg Pediatr 2019 03 22:1-12. Epub 2019 Mar 22.

Department of Surgery, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois; and.

Diffuse villous hyperplasia of the choroid plexus (DVHCP) is a rare cause of communicating hydrocephalus. DVHCP may be diagnosed radiographically and through histological evaluation. It may be associated with genetic abnormalities, particularly involving chromosome 9. Read More

Cancer Imaging 2019 Mar 20;19(1):17. Epub 2019 Mar 20.

Medical Imaging Center, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, No. 16, Ji Chang Lu, Guangzhou, 510405, People's Republic of China.

Background: The therapeutic planning varies for different grades of choroid plexus tumours (CPTs). The aim of this study was to define the similarities and distinctions among MRIs for different grades of CPTs, providing more guidance for clinical decisions.

Methods: We reviewed the MRI findings in 35 patients with CPT verified by surgical pathology, including 18 choroid plexus papillomas (CPPs, grade I), 11 atypical choroid plexus papillomas (aCPPs, grade II), and 6 choroid plexus carcinomas (CPCs, grade III). Read More

J Neurosurg Pediatr 2019 Feb 22:1-6. Epub 2019 Feb 22.

2Beacon Children's Hospital, Beacon Medical Group North Central Neurosurgery, South Bend.

Choroid plexus papillomas (CPPs) are rare, benign tumors that can arise in young children. Most pediatric patients present with signs of hydrocephalus and require immediate treatment. The natural history of choroid plexus tumors in children without hydrocephalus is poorly defined. Read More

Acta Neurochir (Wien) 2019 Apr 19;161(4):745-754. Epub 2019 Feb 19.

Department of Neurosurgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Choroid plexus tumors are rare entities. Resection is the mainstay of treatment in grade I and grade II tumors and adjuvant treatment is usually reserved for the less frequent choroid plexus carcinoma (CPC). Outcome is not only related to their histological grade but also dependent on their size, location, and presence of often multifactorial disturbances of cerebrospinal fluid (CSF) circulation. Read More

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

Acta Neurochir (Wien) 2019 Feb 7;161(2):351-354. Epub 2019 Jan 7.

Department of Pediatric Neurosurgery, Hospital Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Barcelona, Spain.

Choroid plexus tumors (CPT) can present in the baseline magnetic resonance imaging (MRI) with lesions compatible with leptomeningeal dissemination. Therapeutic strategy in this condition is controversial. We present a case of an infant with CPP and significant diffuse leptomeningeal contrast enhancement at diagnosis, which spontaneously resolved after removal of the primary tumor. Read More

Radiol Case Rep 2019 Mar 4;14(3):304-308. Epub 2018 Dec 4.

Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.

Choroid plexus papillomas (CPPs) are rare neoplasms classified as World Health Organization grade I tumors. CPPs containing other tissues have occasionally been documented in the literature. However, few of these previous reports have provided clinical and radiological information. Read More

Cureus 2018 Oct 5;10(10):e3417. Epub 2018 Oct 5.

Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.

Third ventricle tumors are uncommon and account for 0.6 - 0.9% of all the brain tumors. Read More

Chin Med J (Engl) 2018 Dec;131(24):2938-2946

Department of Neurosurgery, Beijing Tiantan Hospital; Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.

Background: Decision-making concerning the treatment of choroid plexus tumor (CPT) in pediatric patients remains a topic of considerable debate. The aim of this work was to describe clinical features and prognostic risk factors of CPT in the pediatric population and to provide theoretical opinions regarding clinical decisions for CPT.

Methods: The data of 96 patients with CPT and younger than 14 years were retrospectively analyzed. Read More

FEMS Microbiol Lett 2018 Dec;365(24)

Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.

Escherichia coli is the most common Gram-negative causative agent of neonatal meningitis and E. coli meningitis is associated with high morbidity and mortality. Previous research has been carried out with regard to the blood-brain barrier and thereby unveiled an assortment of virulence factors involved in E. Read More

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S426-S427. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Infratentorial ependymomas that arise in the fourth ventricle and extend into the cerebellopontine angle (CPA) through the foramina of Luschka are well described. However, a primary CPA location of an ependymoma is distinctly uncommon. In this video, we present a 46-year-old man with episodes of dizziness, left-sided tinnitus, imbalance, double vision, and nausea. Read More

Pediatr Neurosurg 2018 2;53(6):401-406. Epub 2018 Nov 2.

Department of Neurosurgery, Tianjin Children's Hospital, Tianjin, China,

Choroid plexus papilloma (CPP) is a rare benign tumor of the central nervous system. Bilateral lateral ventricle CPP is extremely uncommon. In this case report, we described a case of bilateral lateral ventricle CPP in a 4-month-old female patient conceived by in vitro fertilization (IVF). Read More

Br J Radiol 2019 Feb 3;92(1094):20170872. Epub 2019 Jan 3.

1 Birmingham Children's Hospital , Birmingham , UK.

Objective:: To investigate correlations between MRI perfusion metrics measured by dynamic susceptibility contrast and arterial spin labelling in paediatric brain tumours.

Methods:: 15 paediatric patients with brain tumours were scanned prospectively using pseudo-continuous arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC-) MRI with a pre-bolus to minimise contrast agent leakage. Cerebral blood flow (CBF) maps were produced using ASL. Read More

Sci China Life Sci 2019 Jan 21;62(1):119-125. Epub 2018 Sep 21.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, 100005, China.

The purpose of the present study was to analyze the clinical phenotypes of a girl with oculo-facio-cardio-dental (OFCD) syndrome and to identify the potential pathogenic mutation responsible for her disease. The patient underwent detailed clinical examinations and phenotype data were collected over a follow-up period of 9 years. Mutation analysis of the candidate gene BCOR was performed with polymerase chain reaction and Sanger sequencing. Read More

World Neurosurg 2019 Jan 24;121:e237-e245. Epub 2018 Sep 24.

Department of Neurosurgery AIIMS, New Delhi, India.

Background: Choroid plexus tumors (CPTs) are rare tumors characterized by papillary and intraventricular growth. The young age of presentation of such tumors, especially in infants, and the lack of consensus on adjuvant therapy in case of atypical choroid plexus papilloma (aCPP) and choroid plexus carcinoma (CPC) create dilemma for the management of such tumors. We discuss the presentation, management, complications, and outcome in 15 patients (children 4 years of age and younger) and review pertinent literature. Read More

Medicine (Baltimore) 2018 Sep;97(38):e12466

Department of Physical Medicine and Rehabilitation.

Rationale: Choroid plexus papillomas are rare benign central nervous system neoplasms arising from choroid plexus epithelium. They are most often located in the lateral ventricle, followed by the fourth and third ventricles and, rarely, in the cerebellopontine angle.

Patient Concerns: We report an uncommon case of a 17-year-old boy who presented with neck pain that had lasted for more than 1 month, with accompanying pain and numbness in his upper extremities. Read More

Pediatr Neurosurg 2018 3;53(6):413-415. Epub 2018 Sep 3.

Department of Neurosurgery, Dicle University Medical Faculty, Diyarbakir, Turkey.

Factor XIII deficiency is a rare hemorrhagic disorder that can cause spontaneous intracranial hemorrhage and bleeding after surgery. The diagnosis of factor XIII deficiency is difficult before surgical interventions, because coagulation parameters are normal in these patients. Important clinical findings are postsurgical bleeding and recurrent spontaneous intracranial hematomas. Read More

Pediatr Neurosurg 2018 29;53(6):407-412. Epub 2018 Aug 29.

Department of Neurological Surgery, National Hospital Organization Okayama Medical Center, Okayama, Japan.

Choroid plexus hyperplasia/papilloma and resulting hyperproduction of cerebrospinal fluid is a rare cause of hydrocephalus. In these patients, intractable ascites can occur after a ventriculoperitoneal (VP) shunting operation. However, shunt-related hydrocele is a rare complication of VP shunting. Read More

Cureus 2018 Jun 20;10(6):e2849. Epub 2018 Jun 20.

Neurosurgery, Taipei Veterans General Hospital, Taipei, TWN.

Choroid plexus papillomas (CPPs) are slow-growing and benign tumors, representing less than 1% of all intracranial neoplasms. They are predominantly located in the lateral ventricles in children, and in the fourth ventricle in adults. Primary CPP over sellar regions is extremely rare. Read More

Clin Imaging 2018 Nov - Dec;52:226-239. Epub 2018 Aug 1.

Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.

The MRI appearance of intraventricular neoplasms is often nonspecific, however knowledge of patient age and tumor location facilitates the formulation of a differential diagnosis. Imaging and pertinent clinical features of the following intraventricular neoplasms are reviewed: ependymoma, subependymoma, central neurocytoma, subependymal giant cell tumor, choroid plexus tumors, medulloblastoma, meningioma, chordoid glioma, rosette-forming glioneuronal tumor, central nervous system lymphoma, and metastasis. Read More

Surg Neurol Int 2018 5;9:131. Epub 2018 Jul 5.

Unit of Neurosurgery, S. Elia Hospital, Caltanissetta, Italy.

Background: Choroid plexus tumors (CPTs) are rare neoplasms accounting for only 0.3-0.6% of all brain tumors in adults and 2-5% in children. Read More

Regul Toxicol Pharmacol 2018 Oct 3;98:224-230. Epub 2018 Aug 3.

Pathology Department, Egypt; Faculty of Medicine, Mansoura University, Egypt.

Heavy metal toxicity is a common foodborne problem in Egypt, especially in combination. Molybdenum toxicity has been studied as a model of the heavy metal toxicity. Molybdenum could promote toxicity via oxidative-inflammatory mechanisms. Read More

Int J Med Microbiol 2018 Oct 17;308(7):829-839. Epub 2018 Jul 17.

Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.

The Gram-negative bacterium Haemophilus influenzae (H. influenzae) can commensally colonize the upper respiratory tract, but also cause life threatening disease including epiglottitis, sepsis and meningitis. The H. Read More

J Neurol Surg A Cent Eur Neurosurg 2019 Jan 4;80(1):53-57. Epub 2018 Jul 4.

Department of Neurosurgery, Hokkaido Neurosurgical Memorial Hospital, Sapporo, Japan.

Background:  It is very rare for a choroid plexus tumor to occur intraparenchymally in the absence of a relation to the choroid plexus.

Clinical Presentation:  A case of cerebral intraparenchymal choroid plexus tumor in a 30-year-old woman presenting with left hemiparesis is described. Brain magnetic resonance imaging depicted a large cystic mass in the right frontal lobe. Read More

Pediatr Blood Cancer 2018 Oct 26;65(10):e27294. Epub 2018 Jun 26.

Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, Canada.

J Neurooncol 2018 Sep 16;139(3):777-778. Epub 2018 May 16.

Division of Pediatric Hematology/Oncology, Children's Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.

Neurosurgery 2019 Mar;84(3):636-646

Department of Neurosurgery, Great Ormond Street Hospital for Children, London, UK.

Background: Brain tumors in the first year of life are rare and their management remains challenging.

Objective: To report on the contemporary management of brain tumors in infants with reference to previous series from our institution.

Methods: Retrospective cohort study design. Read More

Oper Neurosurg (Hagerstown) 2018 Nov;15(5):E53-E54

Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania.

A 26-year-old woman presented to our clinic with years of headaches and mental clouding. She had a nonfocal neurological examination including benign ophthalmological examination. Head computed tomography and brain magnetic resonance imaging (MRI) demonstrated asymmetry of the lateral ventricles due to a lesion arising from the foramen of Monro. Read More

Neuroradiology 2018 May 15;60(5):479-486. Epub 2018 Mar 15.

Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan.

Purpose: To explore the utility of the apparent diffusion coefficient (ADC) and tumor volume to predict histological grade and prognosis in patients with choroid plexus tumors.

Methods: ADC and tumor volumes were retrospectively evaluated in 25 patients with choroid plexus papilloma (CPP; WHO grade 1 [n = 13]), atypical CPP (aCPP; grade 2 [n = 8]), or choroid plexus carcinoma (grade 3 [n = 4]) The prognostic roles of ADC and tumor volume were assessed.

Results: There were significant differences in mean and minimum ADC values, and tumor volume among the WHO grades (p = 0. Read More

Asian J Neurosurg 2018 Jan-Mar;13(1):191-194

Department of Pathology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.

Choroid plexus papilloma is a rare intracranial neoplasm. These lesions most commonly present in the fourth ventricle in adults and lateral ventricle in children. Herein, we report a case of a 57-year-old male with complaint of backache of few weeks duration. Read More

World Neurosurg 2018 May 13;113:129-134. Epub 2018 Feb 13.

Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Neurosurgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Objective: In vitro fertilization (IVF) is increasingly used for the treatment of infertile couples worldwide. The association between IVF and cancer risk in offspring is conflicting. We present a case of atypical teratoid/rhabdoid tumor (AT/RT) in a girl conceived by IVF and present results of systematic review of literature of primary intracranial neoplasms diagnosed in children conceived by IVF. Read More

Oncol Lett 2018 Mar 18;15(3):3081-3084. Epub 2017 Dec 18.

Division of Genetics, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and exhibits an organ-dependent expression pattern in cancer. PSCA is upregulated in prostate cancer and downregulated in gastric cancer. PSCA is expressed in a variety of human organs. Read More

Vet Pathol 2018 05 5;55(3):391-401. Epub 2018 Feb 5.

2 Division of Neurological Sciences, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Choroid plexus tumors (CPT) are intraventricular neoplasms accounting for 10% of all primary central nervous system tumors in dogs. They are frequently classified according to the human WHO classification into choroid plexus papilloma (CPP, grade I), atypical CPP (aCPP, grade II), and choroid plexus carcinoma (CPC, grade III). Histological features observed in canine CPT such as increased vascular density (IVD) and glomeruloid microvascular proliferation (GMVP) are not part of the WHO classification. Read More

Emerg Radiol 2018 Apr 3;25(2):215-218. Epub 2018 Feb 3.

Department of Radiology, Radiology Specialists of Florida, Maitland, FL, USA.

Retinal detachment with subsequent silicone oil retinopexy is not uncommon. A known complication of silicone retinopexy is intraventricular migration of the intraocular silicone oil. While the oil itself does not result in direct pathology, misdiagnosis may lead to an unnecessary diagnostic workup and possibly predispose the patient to surgery intervention. Read More

J Neurosurg Pediatr 2018 04 2;21(4):428-433. Epub 2018 Feb 2.

3Division of Pediatric Neurosurgery, University of Florida Health, Jacksonville, Florida.

Primary choroid plexus tumors encompass a variety of tumors, with choroid plexus papilloma and carcinoma being the most common. Also in the differential diagnosis is the rare benign choroid plexus adenoma. As these tumors are infrequently described, the histological profile continues to evolve. Read More

Pract Neurol 2018 04 23;18(2):137-142. Epub 2018 Jan 23.

Department of Molecular Neuroscience, MRC Centre for Neuromuscular Diseases, National Hospital of Neurology and Neurosurgery, UCL Institute of Neurology, London, UK.

Rev Chilena Infectol 2017 Aug;34(4):383-388

Anatomía Patológica, Hospital Luis Calvo Mackenna, Chile.

Bartonella henselae infection is a prevalent illness in Chile. It presents generally as a cat scratch disease or as a prolonged fever syndrome. There are atypical manifestations, which include central nervous system, bone, cardiac and hepato-esplenic compromised. Read More

Neuropsychologia 2017 Oct 31. Epub 2017 Oct 31.

Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Department of Developmental Neuroscience, Stella Maris Scientific Institute, Pisa, Italy. Electronic address:

In adults, partial damage to V1 or optic radiations abolishes perception in the corresponding part of the visual field, causing a scotoma. However, it is widely accepted that the developing cortex has superior capacities to reorganize following an early lesion to endorse adaptive plasticity. Here we report a single patient case (G. Read More

Oper Neurosurg (Hagerstown) 2018 Aug;15(2):184-193

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: The use of intraoperative navigation during microscope cases can be limited when attention needs to be divided between the operative field and the navigation screens. Heads-up display (HUD), also referred to as augmented reality, permits visualization of navigation information during surgery workflow.

Objective: To detail our initial experience with HUD. Read More

Immunol Res 2017 12;65(6):1110-1123

Neuroanatomy, University Medical Center Göttingen, Göttingen, Germany.

Chlamydia trachomatis (CT) and the Chlamydophila species (CS) Chlamydophila pneumoniae (CPn), and Chlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT (α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent interaction partner with both α-CT and α-CS was the ribosomal small subunit protein RPS27a. Read More

World Neurosurg 2017 Dec 1;108:990.e1-990.e9. Epub 2017 Sep 1.

Neurosurgery Department, CHRU de Tours, Tours, France; Brain and Imaging, Université François-Rabelais de Tours, UMR Inserm U930, Tours, France.

Background: Choroid plexus papilloma revealed by nontraumatic cerebrospinal fluid (CSF) rhinorrhea has only been described 5 times, to our knowledge, in the literature. The challenges in this situation are to recognize CSF leak, to rapidly understand the pathophysiology of the leak, and to choose the best treatment strategy in emergency. We report an original case of posterior fossa choroid plexus papilloma revealed by CSF leak. Read More

J Neurosurg Pediatr 2017 Nov 25;20(5):471-479. Epub 2017 Aug 25.

UCSF Benioff Children's Hospital Oakland, California.

Choroid plexus papillomas (CPPs) are typically benign tumors that can occur in any age group but are more commonly found in pediatric patients. Although these tumors are benign, there are several reports in adult patients of distant metastases present either at the time of diagnosis or occurring months to years after initial resection. Here, the authors report the case of a 14-year-old boy who presented with symptoms of elevated intracranial pressure due to obstructive hydrocephalus that was caused by a large fourth ventricular mass. Read More

Oncol Lett 2017 Aug 7;14(2):1802-1806. Epub 2017 Jun 7.

Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, Shandong 250012, P.R. China.

The World Health Organization classification of choroid plexus tumors (CPT) includes three distinct grades: Choroid plexus papilloma (CPP), atypical choroid plexus papilloma (ACPP) and choroid plexus carcinoma (CPC). The molecular basis for these pathological distinctions may help to stratify tumors and provide an insight into the clinical behavior of CPTs. In the present study, the progenitor and stem cell markers neuron glia antigen-2 (NG2) and sex-determining region Y-box 2 (SOX2) were investigated as potential biomarkers that may distinguish between distinct CPT grades. Read More

Clin Med (Lond) 2017 07;17(4):384

South West Acute Hospital, Enniskillen, Northern Ireland, UK.

J Neurosurg Pediatr 2017 Sep 7;20(3):284-288. Epub 2017 Jul 7.

Neuro-Oncology Unit.

Atypical choroid plexus papillomas can metastasize in the form of leptomeningeal seeding. Postoperative chemotherapy is the recommended first-line treatment when gross-total removal is not achieved or in cases of disseminated disease. Here the authors report on 2 children with atypical choroid plexus papillomas and MRI findings of diffuse leptomeningeal enhancement at diagnosis, later presenting with spontaneous resolution of the leptomeningeal involvement after removal of the primary lesions. Read More

World Neurosurg 2017 Sep 3;105:1039.e13-1039.e18. Epub 2017 Jul 3.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Background: Choroid plexus papillomas (CPPs) are rare benign tumors, and the pigmented subtype is observed even more rarely.

Case Description: We present the case of a 43-year-old woman with complaints of headache and progressive left monocular visual deterioration, whose initial plain computed tomography CT scan showed an ovate high-density tumor located within the insellar region. Magnetic resonance imaging revealed a homogeneously contrast-enhancing tumor extending from the sella turcica to the suprasellar cistern. Read More