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Clin Ophthalmol 2020 24;14:1725-1734. Epub 2020 Jun 24.

KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objective: To compare the efficacy of oral spironolactone treatment versus conservative treatment for patients with persistent central serous chorioretinopathy (CSC) in real-life practice.

Design: Retrospective comparative study.

Patients And Methods: Medical records and retinal images of 62 patients with non-resolving CSC were reviewed. Read More

J Clin Med 2020 Jun 29;9(7). Epub 2020 Jun 29.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

The emergence of pachychoroid disease is changing the concept of age-related macular degeneration (AMD). The concept of pachychoroid diseases was developed through clinical observation of multimodal images of eyes with AMD and central serous chorioretinopathy; however, recent genetic studies have provided a proof of concept for pachychoroid spectrum disease, which should be differentiated from drusen-driven AMD. The genetic confirmation of pachychoroid concept further provides novel viewpoints to decode previously reported findings, which facilitates an understanding of the true nature of pachychoroid diseases and AMD. Read More

Retina 2020 Jun 26. Epub 2020 Jun 26.

Vitreous Retina Macula Consultants of New York, New York.

Purpose: To develop a method of averaging optical coherence tomography (OCT) angiography to improve visualization of choriocapillaris structure.

Methods: A stack of OCT angiographic data from vascular layers were placed into the red-green-blue channels of a conventional digital color image. The superficial plexus was placed in the blue channel, choriocapillaris in the green, and deep vascular plexus in the red channel. Read More

J Clin Med 2020 Jun 21;9(6). Epub 2020 Jun 21.

Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK.

The diagnosis and treatment of choroidal neovascularization (CNV) in eyes with chronic central serous chorioretinopathy (CSCR) can be challenging. The purpose of this study was to classify eyes with suspected CNV using multimodal imaging. The effect of intravitreal anti-vascular endothelial growth factor (VEGF) was assessed and compared to controls. Read More

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Byers Eye Institute, Department of Ophthalmology, Stanford University. Electronic address:

Purpose: To determine the incidence of central serous chorioretinopathy (CSC) stratified by age, sex, and diagnosis with obstructive sleep apnea (OSA), and to determine whether some patients with newly diagnosed CSC may be candidates for OSA evaluation.

Design: Retrospective cohort study.

Methods: We used the IBM Marketscan database to select 59,016,145 commercially-insured patients in the United States between 2007 and 2016. Read More

Ophthalmic Res 2020 Jun 19. Epub 2020 Jun 19.

Background Central serous chorioretinopathy (CSCR) is a chorioretinal disorder resulting from choroidal hyperpermeability. Its comorbidities as hypertension, coronary disease and psychological stress, suggest that it might reflect a more generalized vascular dysfunction. Objectives To assess the cerebrovascular regulation integrity, using cerebral autoregulation (CA), carbon dioxide vasoreactivity (VR) and neurovascular coupling (NVC) in CSCR. Read More

Eye (Lond) 2020 Jun 16. Epub 2020 Jun 16.

Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China.

Objectives: To investigate the relationship between photoreceptor layer (PRL) changes before half-dose photodynamic therapy (PDT) and functional and anatomic outcomes in central serous chorioretinopathy (CSC).

Methods: Baseline PRL changes were classified based on optical coherence tomography: (1) smooth PRL outer border without a foveal PRL defect; (2) smooth PRL outer border with a foveal PRL defect; (3) granulated PRL outer border and (4) scattered dots of PRL. The best-corrected visual acuity (BCVA), difference in the foveal outer nuclear layer (ONL) thickness between the CSC and normal contralateral eyes and ellipsoid zone (EZ) integrity 12 months after half-dose PDT were compared. Read More

Sci Rep 2020 Jun 12;10(1):9591. Epub 2020 Jun 12.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

This study was to investigate the choroidal vessels in eyes with central serous chorioretinopathy (CSC) quantitatively. We studied 41 CSC eyes and their fellow eyes, and 41 normal eyes of 41 age-adjusted individuals. En-face optical coherence tomography image of the top 25% slab of Haller's layer was analyze. Read More

Br J Ophthalmol 2020 Jun 12. Epub 2020 Jun 12.

Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong, China

Purpose: The purpose of this study was to investigate the signal changes in choriocapillaris flow deficits and choroidal thickness changes using swept-source optical coherence tomography angiography (OCTA) following different treatments.

Design: A double-blind, randomised controlled trial.

Methods: Patients with unilateral chronic central serous chorioretinopathy (CSC) were randomised to receive subthreshold micropulse laser therapy (MLT) or half-dose photodynamic therapy (PDT). Read More

Ther Adv Ophthalmol 2020 Jan-Dec;12:2515841420923192. Epub 2020 May 29.

Manchester Royal Eye Hospital, Manchester University Foundation Trust, Manchester, UK.

Aim: The aim of this study was to prospectively define the characteristics and outcomes of a cohort of central serous chorioretinopathy patients using optical coherence tomography imaging to determine anatomical disease resolution. Much of the literature available on the characteristics of central serous chorioretinopathy patients pre date the advent of OCT imaging, with conclusive epidemiological evidence being scarce. We describe a cohort of patients presenting to a large centre over the course of a year. Read More

JAMA Ophthalmol 2020 Jun 11;138(6):e193120. Epub 2020 Jun 11.

Dr Shroff's Charity Eye Hospital, Daryaganj, New Delhi, India.

Ophthalmol Retina 2020 Jun 7. Epub 2020 Jun 7.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, USA; Jonas Children's Vision Care, and Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative, Department of Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Int J Retina Vitreous 2020 4;6:11. Epub 2020 Jun 4.

Internationale Innovative Ophthalmochirurgie, Theo-Champion-Str. 1, 40549 Duesseldorf, Germany.

Background: To evaluate the outcomes of subthreshold nanosecond laser treatment of chronic central serous chorioretinopathy (CSC) as a function of the severity of concomitant of retinal pigment epithelium (RPE) defects.

Methods: This retrospective study compares data from 23 CSC diagnosed eyes with only mild RPE defects (group 1), 16 CSC eyes with moderate RPE defects (group 2), and 17 CSC eyes having severe RPE defects (group 3). After subthreshold treatment with the standard Ellex 2RT™ nanosecond laser (Ellex Medical Lasers Ltd, Australia), changes in macular structure and levels of subretinal fluid (SRF) were assessed by OCT-SD, OCT-A, functional integrity of the retina was assessed by corrected distance visual acuity (CDVA) and microperimetry, each at baseline and 1, 3, 6, and 12 months after initial treatment; re-treatment took place in cases of persistent SRF . Read More

Clin Exp Ophthalmol 2020 Jun 7. Epub 2020 Jun 7.

Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia.

BMC Ophthalmol 2020 Jun 5;20(1):219. Epub 2020 Jun 5.

Department of Retina & Vitreous, Narayana Nethralaya, 121/C, Chord Road, 1st 'R' Block, Rajaji Nagar, Bengaluru, 560010, India.

Background: Minoxidil solution has routinely been used for decades for the treatment of androgenic alopecia. Central serous chorioretinopathy (CSCR) is a rare side-effect noted following prolonged topical minoxidil therapy for androgenic alopecia. In this report, we describe a case of a 41-year-old young man who developed CSCR following prolonged therapy with topical Minoxidil solution and was treated with oral eplerenone. Read More

Clin Exp Ophthalmol 2020 Jun 4. Epub 2020 Jun 4.

Westmead and Central Clinical Schools, Discipline of Ophthalmology and Eye Health, The University of Sydney, Sydney, Australia.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 3. Epub 2020 Jun 3.

Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #327 Sosa-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14647, Republic of Korea.

Purpose: We sought to compare choroidal vascular characteristics of central serous chorioretinopathy (CSC), polypoidal choroidal vasculopathy (PCV), and age-related macular degeneration (AMD) using quantitative analyses of ultra-widefield indocyanine green (UWF ICGA) images.

Methods: Eyes with CSC (n = 57), thick-choroid PCV (n = 29), thin-choroid PCV (n = 25), neovascular AMD (n = 45), and pachychoroid neovasculopathy (PNV) (n = 28) were enrolled. On UWF ICGA images, choroidal vascular density (CVD) was assessed using binarization in the total area, posterior pole, each quadrant, and vortex ampullae. Read More

Pregnancy Hypertens 2020 May 29;21:111-117. Epub 2020 May 29.

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Objectives: To investigate the relationship between serum total protein (TP) levels and maternal/neonatal outcomes among pregnant women with preeclampsia.

Study Design: TP was measured at preeclampsia diagnosis and delivery in 94 women with singleton pregnancies and preeclampsia as hypertension with proteinuria who delivered at ≥ 22 gestational weeks (GWs). As a control group, measurements were also made in 188 women with singleton pregnancies without hypertension and/or proteinuria. Read More

Clin Ophthalmol 2020 29;14:1165-1175. Epub 2020 Apr 29.

Department of Ophthalmology, Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: To study the risk of recurrence in acute central serous chorioretinopathy (aCSC) and to evaluate the risk of transitioning to chronic CSC.

Patients And Methods: The medical records and multimodal imaging data of 295 aCSC cases were reviewed. Typical aCSC was defined as the presence of serous subretinal fluid (SRF), one focal leakage spot on fluorescein angiography (FA), retinal pigment epithelium (RPE) alterations limited in area to less than one optic disc diameter, and complete recovery from this first CSC episode. Read More

Doc Ophthalmol 2020 May 18. Epub 2020 May 18.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, South Kargar Street, Tehran, 1336616351, Iran.

Purpose: To describe a patient with combined central serous chorioretinopathy and achromatopsia.

Methods: Clinical examination, enhanced depth imaging- optical coherence tomography, fundus autofluorescence, fluorescein angiography and electroretinography were used to study a 33-year-old female presented with the complaint of poor vision since childhood in both eyes, which worsened in the left eye (LE) recently.

Results: In slit-lamp examination, there was a macular elevation in the LE and macular pigmentary change as well as optic disk pallor in both eyes. Read More

Graefes Arch Clin Exp Ophthalmol 2020 May 15. Epub 2020 May 15.

Department of Ophthalmology, Ankara University School of Medicine, Vehbi Koç Eye Hospital, Mamak Street, Dikimevi, Ankara, Turkey.

Purpose: To evaluate the choroidal vascularity index (CVI) in the fellow eyes of patients with pachychoroid neovasculopathy (PCN) and central serous chorioretinopathy (CSC).

Methods: Fifty-eight asymptomatic fellow eyes from 58 patients diagnosed with PCN or CSC and 26 eyes from 26 healthy participants were included. The total choroidal area (CA), luminal area (LA), and stromal area (SA) were measured with ImageJ software and Niblack threshold method. Read More

Prog Retin Eye Res 2020 May 11:100865. Epub 2020 May 11.

Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, SO16 6YD, United Kingdom. Electronic address:

Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Read More

Retina 2020 May 11. Epub 2020 May 11.

Ophthalmology Department, San Raffaele University Hospital, Milan, Italy.

Purpose: To quantitatively evaluate the photoreceptor structural changes in the fellow unaffected eyes of patients with unilateral central serous chorioretinopathy (CSC).

Methods: This is a retrospective cross-sectional study. We analyzed data from patients with diagnosis of unilateral CSC, as based on clinical examination and multimodal imaging, who had structural optical coherence tomography obtained. Read More

Eur J Ophthalmol 2020 May 6:1120672120921369. Epub 2020 May 6.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, LV Prasad Eye Institute, Hyderabad, India.

Aim: To report the prevalence and characteristics of outer retinal tubulations in eyes with choroidal neovascularisation associated with chronic central serous chorioretinopathy.

Methods: Retrospective case series which included evaluation of optical coherence tomography B-scans and enface optical coherence tomography scans of eyes with choroidal neovascularisation associated with chronic central serous chorioretinopathy. The characteristics of outer retinal tubulations such as number, shape and distribution were noted. Read More

Am J Ophthalmol 2020 Apr 28. Epub 2020 Apr 28.

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States; Greater Los Angeles VA Healthcare Center, Los Angeles CA. Electronic address:

Purpose: To study the early anatomical choroidal alterations in eyes with chronic central serous chorioretinopathy (CSCR) undergoing photodynamic therapy (PDT).

Design: Multicenter retrospective cohort study.

Methods: A total of 77 patients and 81 eyes with chronic CSCR treated with PDT and 64 untreated fellow eyes were evaluated. Read More

Retina 2020 Apr 16. Epub 2020 Apr 16.

Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Peking University People's Hospital, Beijing, China.

Purpose: To compare the anatomic results of optical coherence tomography angiography (OCTA)-guided half-dose photodynamic therapy (PDT) versus indocyanine green angiography (ICGA)-guided PDT in eyes with acute central serous chorioretinopathy.

Methods: This study is a prospective, single-center, noninferiority, double-masked, randomized, controlled clinical trial. Fifty-one eyes of 45 patients with acute central serous chorioretinopathy were recruited, and randomized to an ICGA-guided group and an OCTA-guided group. Read More

Int Ophthalmol 2020 Apr 24. Epub 2020 Apr 24.

Eye Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5D-79106, Freiburg, Germany.

Purpose: To characterize the choriocapillaris (CC) structure in relation to subretinal fluid (SRF) as a possible systematic error source using spectral domain (SD-OCTA) compared to swept-source optical coherence tomography angiography (SS-OCTA).

Methods: This is a prospective case-control study of 23 eyes. Ten patients with acute central serous chorioretinopathy (CSC), three patients with partial macular-off retinal detachment (RD) and ten healthy, age-matched controls were included. Read More

Jpn J Ophthalmol 2020 Jul 21;64(4):323-337. Epub 2020 Apr 21.

Department of Ophthalmology, Asahikawa Medical University, Hokkaido, Japan.

Background: Pachychoroid, or the structural and functional abnormalities of the choroid, is one of the most important causes of exudative maculopathies. The purpose of this article is to review the current definitions of pachychoroid and their potential consequences. Most publications are from Asian countries. Read More

Indian J Ophthalmol 2020 May;68(5):866-867

Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru, Karnataka, India.

Indian J Ophthalmol 2020 May;68(5):861-866

Department of Vitreo Retina, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

Purpose: The current study compares the ability of multicolor imaging (MCI) to detect the lesions of central serous chorioretinopathy against conventional color fundus photographs (CFP).

Methods: It was a retrospective, observational case series of 93 eyes of 58 patients of central serous chorioretinopathy who underwent MCI and CFP. MCI and spectral-domain optical coherence tomography (SD-OCT) were performed using Spectralis SD-OCT system (HRA + OCT). Read More

Indian J Ophthalmol 2020 May;68(5):858-859

Chaithanya Eye Hospital and Research Institute; CITE, Trivandrum, Kerala, India.

Indian J Ophthalmol 2020 May;68(5):854-858

Department of Ophthalmology, The Kayseri City Hospital, Kayseri, Turkey.

Purpose: To investigate monocyte to high-density lipoprotein (HDL) ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) as indicators of systemic inflammation in acute central serous chorioretinopathy (CSC).

Methods: The HDL levels, hematological profiles, erythrocyte sedimentation rates (ESR), and C-reactive protein (CRP) levels of 38 patients with acute CSC (Group I) and 38 controls without CSC (Group II) were measured.

Results: MHRs were significantly higher in Group I (13. Read More

Retina 2020 Apr 14. Epub 2020 Apr 14.

Centro Italiano Macula", Rome, Italy.

Purpose: To evaluate the incidence of neovascularization (NV) secondary to central serous chorioretinopathy (CSC)-a condition belonging to the spectrum of pachychoroid disorders by means of optical coherence tomography angiography.

Methods: One hundred and seventy five eyes with CSC were evaluated in this retrospective observational study. The eyes with acute or chronic CSC with no NV were included in Group 1, and those with NV were evaluated in Group 2. Read More

Eye (Lond) 2020 Apr 14. Epub 2020 Apr 14.

Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People's Hospital, Beijing, China.

Background: To compare the outcomes of half-dose verteporfin photodynamic therapy (vPDT) for central serous chorioretinopathy (CSCR) with or without subfoveal fibrin.

Methods: One hundred seventy-three cases of CSCR treated with half-dose vPDT between September 2008 and February 2018 were retrospectively reviewed and classified into two groups: CSCR with subfoveal fibrin (fibrin group) and without subfoveal fibrin (no-fibrin group). The changes in best-corrected visual acuity (BCVA) from baseline and in central macular thickness (CMT) were recorded at 1, 3, and 6 months after the treatment. Read More

Am J Ophthalmol 2020 Apr 11. Epub 2020 Apr 11.

Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands.

Purpose: To assess whether chronic central serous chorioretinopathy (cCSC) patients without a complete resolution of subretinal fluid (SRF) after either half-dose photodynamic therapy (PDT) or high-density subthreshold micropulse laser (HSML) treatment may benefit from cross-over treatment.

Design: Multi-center prospective interventional case series.

Methods: cCSC patients with persistent SRF at the final visit of the PLACE trial were included. Read More

Clin Exp Optom 2020 Apr 13. Epub 2020 Apr 13.

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.

Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality for assessing the vasculature within ocular structures including the retina, macula, choroid and optic nerve. OCT-A has a wide range of clinical applications in various optometric conditions which have been independently reported in the literature. This paper aims to present a review of the current literature on the clinical application of OCT-A in optometric practice as well as to analyse and evaluate the quality of the available evidence. Read More

Medicine (Baltimore) 2020 Apr;99(15):e19536

Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

This study analyzed cone density, cone mosaic, and fundus autofluorescence (FAF) images in patients with focal laser-treated central serous chorioretinopathy (CSC).Observational case series.Forty-two eyes of 21 patients with unilateral treated CSC and bilateral best-corrected visual acuity of 1. Read More

Ophthalmol Ther 2020 Jun 11;9(2):329-342. Epub 2020 Apr 11.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Photodynamic therapy (PDT) using verteporfin (Visudyne®; Bausch + Lomb) is a treatment that is widely used to elicit cell and tissue death. In ophthalmology, PDT targets choroidal vascular abnormalities and induces selective occlusion of vessels. PDT was originally used in combination with full-dose verteporfin to treat neovascular age-related macular degeneration. Read More

Int Ophthalmol 2020 Jul 9;40(7):1807-1813. Epub 2020 Apr 9.

Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.

Purpose: The aim of this study is to investigate the results of fluorescein angiography (FA)-guided reduced-fluence photodynamic therapy (PDT) in the treatment of chronic central serous chorioretinopathy (CSCR), with the hypothesis that indocyanine green angiography (ICGA) guidance is avoidable in some cases.

Methods: This retrospective study includes a consecutive nonrandomized series of chronic CSCR cases. All eyes were examined with FA and the ones that had discrete active leakage areas or points had undergone reduced-fluence PDT. Read More

Retina 2020 Apr 8. Epub 2020 Apr 8.

Bennett & Bloom Eye Centers, Louisville, Kentucky.

Purpose: To evaluate the optical coherence tomography (OCT) imaging findings in recent onset neurosensory retinal detachments induced by central serous chorioretinopathy and to attempt to corroborate these findings with proposed anatomical correlates.

Methods: Retinal detachments due to central serous chorioretinopathy of less than 3 months' duration and the surrounding area were scanned with OCT. The imaging of the outer retinal bands was evaluated according to proposals by Cuenca et al and the IN•OCT Consensus classification. Read More

Graefes Arch Clin Exp Ophthalmol 2020 Jul 8;258(7):1575-1577. Epub 2020 Apr 8.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai, Miyagi-ken, 980-8574, Japan.

Br J Ophthalmol 2020 Apr 7. Epub 2020 Apr 7.

Shandong Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Background: To identify and analyse the character and relationship between flat irregular pigment epithelial detachment feature (FIPED), choroidal thickness and choroidal neovascularisation (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with central serous chorioretinopathy (CSCR) in Chinese patients.

Method: In the present study, 152 eyes of 144 Chinese patients, who were previously diagnosed with CSCR, were retrospectively studied. Patients' baseline characteristics, the course of CSCR, best-corrected visual acuity, the pattern of CNV on OCTA, FIPED and choroidal thickness detected by enhanced depth imaging-OCT (EDI-OCT) were analysed. Read More

Eur J Ophthalmol 2020 Apr 8:1120672120915168. Epub 2020 Apr 8.

The Rotterdam Eye Hospital, Rotterdam, The Netherlands.

Purpose: The purpose of the study was to demonstrate whether photodynamic therapy in patients with acute central serous chorioretinopathy, with the leakage point within one optic disk diameter from the fovea, can be safely deferred.

Methods: A single-center, randomized, controlled trial was conducted. Patients were randomized to photodynamic therapy within a week after presentation (Group I, 26 patients) or observation during 3 months (Group II, 26 patients). Read More

BMC Ophthalmol 2020 Apr 6;20(1):133. Epub 2020 Apr 6.

IRCCS Sacro Cuore Don Calabria Hospital, Via Don Sempreboni 5 - Negrar, 37024, Verona, Italy.

Background: Bullous serous retinal detachment (RD) with retinal pigment epithelial (RPE) tear is a rare and severe variant of chronic central serous chorioretinopathy (CSC). Due to its atypical presentation, it may raise diagnostic issues, leading to inappropriate therapeutic procedures. The optimum treatment for this CSC variant is still uncertain. Read More

Retina 2020 Apr 1. Epub 2020 Apr 1.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.

Purpose: To describe the multimodal imaging characteristics of flat irregular pigment epithelial detachment (FIPED) in patients with chronic central serous chorioretinopathy and determine the risk factors for vascularized FIPED and to explore the activity of vascularized FIPED before and after half-dose photodynamic therapy.

Methods: Multimodal imaging data of 185 eyes of 155 consecutive patients with chronic central serous chorioretinopathy included spectral domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography. Optical coherence tomography angiography was available for 56 eyes. Read More

J Neuroophthalmol 2020 Mar 24. Epub 2020 Mar 24.

Neurophysiology of Vision and Neuroophthalmology Unit (LZ, LB, VP), IRCCS-Fondazione Bietti, Rome, Italy; Medical Retina Unit (DDG, PG, MP), IRCCS-Fondazione Bietti, Rome, Italy; and Multiple Sclerosis Clinical and Research Unit (DL, GAM, MA), Department of Systems Medicine, Tor Vergata University, Rome, Italy.

Sci Rep 2020 Mar 27;10(1):5640. Epub 2020 Mar 27.

Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan.

This study was performed to estimate choroidal thickness by fundus photography, based on image processing and deep learning. Colour fundus photography and central choroidal thickness examinations were performed in 200 normal eyes and 200 eyes with central serous chorioretinopathy (CSC). Choroidal thickness under the fovea was measured using optical coherence tomography images. Read More

Am J Ophthalmol Case Rep 2020 Jun 5;18:100651. Epub 2020 Mar 5.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose: To evaluate chronological changes in choroidal blood flow velocity in two patients with pachychoroid pigment epitheliopathy (PPE) and central serous chorioretinopathy (CSC) in the same eye.

Observations: Two males aged 36 and 43 years old with PPE were diagnosed with CSC in the same eyes during follow-up. Using laser speckle flowgraphy, the macular mean blur rate (MBR), an index of relative blood flow velocity, was sequentially evaluated in the affected and unaffected eyes. Read More

Photodiagnosis Photodyn Ther 2020 Jun 18;30:101742. Epub 2020 Mar 18.

Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.

Background: To perform a quantitative analysis of retinal and choriocapillaris vessel density (VD) in patients with central serous chorioretinopathy (CSC) after low-fluence verteporfin photodynamic therapy (vPDT), using Optical Coherence Tomography Angiography (OCTA).

Methods: A total of 28 eyes of 27 patients with CSC (21 females, 6 males, mean age 47 ± 11 years) were included in this retrospective study. At baseline and after 6 months after vPDT, we evaluated VD of the superficial capillary plexus (SCP), the deep capillary plexus (DCP) and the choriocapillaris (CC) in different macular areas (whole image, parafovea and fovea). Read More

Arch Soc Esp Oftalmol 2020 May 18;95(5):248-253. Epub 2020 Mar 18.

Servicio de Oftalmología, Hospital Universitario 12 de Octubre, Madrid, España.

The case is reported of a 73-year-old male presenting with the recently described peripapillary pachychoroid syndrome. This syndrome is included in the pachychoroid diseases, which is a relatively new condition characterised by increased choroidal thickness with attenuation of the choriocapillary layer located above dilated choroidal vessels. It is associated with progressive malfunction of the retinal pigment epithelium and neovascularisation. Read More