Search Our Scientific Publications & Authors

Pediatr Radiol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatric Radiology, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

Background: Solitary epiphyseal lesions are rare and present with nonspecific imaging features. Knowledge regarding etiologies of pediatric epiphyseal lesions is limited to small studies.

Objective: The purpose of this study was to determine the relative incidence of pathologies affecting the pediatric epiphysis based on biopsy-proven cases with imaging. Read More

Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Neuroendocrine Tumor Unit, Department of Endocrinology, ENETS Centre of Excellence.

Objective: Von Hippel-Lindau (VHL) syndrome is a rare and complex disease. We described in 1996 a three generation VHL 2A kindred with 11 mutation carriers. We aim to share our experience regarding the long-term follow-up of this family and the management of all our other VHL patients focusing on frequently encountered neuroendocrine tumors: pheochromocytoma/paraganglioma and pancreatic neuroendocrine neoplasms (PNEN). Read More

FP Essent 2020 Jun;493:22-26

UNC Orthopaedics, 130 Mason Farm Road CB# 7055, Chapel Hill, NC 27599-7055.

The three most common primary bone cancers are osteosarcoma, Ewing sarcoma, and chondrosarcoma. Osteosarcoma occurs most often in children and young adults, with a peak incidence at ages 10 to 14 years. It also can occur later in life due to malignant transformation of benign bone lesions. Read More

Clin Orthop Relat Res 2020 Jun 10. Epub 2020 Jun 10.

A. Gulia, V. Kurisunkal, A. Puri, N. Purandare, S. Gupta, V. Rangarajan, Department of Surgical Oncology, Tata Memorial Hospital, HBNI, Mumbai, India.

Background: Staging of a bone sarcoma before initiating treatment helps orthopaedic oncologists determine the intent of treatment and predicting the prognosis. As per National Comprehensive Cancer Network (NCCN) and European Society for Medical Oncology (ESMO) guidelines, there are no exclusive recommendations for chondrosarcoma staging. They are staged similar to other bone sarcomas even though skeletal metastases are extremely rare in chondrosarcomas. Read More

Eur J Radiol 2020 Jul 7;128:109043. Epub 2020 May 7.

Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy; IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.

Purpose: To evaluate the diagnostic performance of machine learning for discrimination between low-grade and high-grade cartilaginous bone tumors based on radiomic parameters extracted from unenhanced magnetic resonance imaging (MRI).

Methods: We retrospectively enrolled 58 patients with histologically-proven low-grade/atypical cartilaginous tumor of the appendicular skeleton (n = 26) or higher-grade chondrosarcoma (n = 32, including 16 appendicular and 16 axial lesions). They were randomly divided into training (n = 42) and test (n = 16) groups for model tuning and testing, respectively. Read More

Acta Orthop 2020 May 20:1-8. Epub 2020 May 20.

Department of Orthopedics, Radboud University Medical Center; Nijmegen.

Background and purpose - Adequate staging of chondroid tumors at diagnosis is important as it determines both treatment and outcome. This systematic review provides an overview of MRI criteria used to differentiate between atypical cartilaginous tumors (ACT) and high-grade chondrosarcoma (HGCS).Patients and methods - For this systematic review PubMed and Embase were searched, from inception of the databases to July 12, 2018. Read More

Laryngoscope 2020 May 15. Epub 2020 May 15.

Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

Objectives/hypothesis: The contralateral transmaxillary (CTM) approach is a new surgical approach that improves the surgical trajectory relative to the petrous segment of the internal carotid artery (ICA). Here, we present our clinical experience with the CTM approach to the petroclival region of the skull base.

Study Design: Retrospective review. Read More

J Neurosci Rural Pract 2020 Apr 2;11(2):344-348. Epub 2020 May 2.

Department of Plastic Surgery, BLK Super Speciality Hospital, New Delhi, India.

Mesenchymal chondrosarcoma of the brain is one of the rarest tumors with dismal prognosis. A 26-year-old man presented with headache, vomiting, and diplopia. On evaluation, a moderately enhancing extra-axial lesion was seen in right temporal region involving right greater wing of sphenoid, adjacent right maxillary sinus, and lateral wall of right orbit. Read More

Radiologe 2020 Apr 22. Epub 2020 Apr 22.

Department of Orthopaedic Surgery, Rigshospitalet, University of Copenhagen., Copenhagen, Denmark.

Enchondromas (EC) are frequent incidental findings on magnetic resonance imaging (MRI) performed for the diagnosis of joint pathology, especially observed on MRI examinations of the knee and shoulder. Enchondroma has potential for malignant transformation to chondrosarcoma (CS), and it may be difficult to distinguish EC from low-malignant CS on the basis of imaging or histopathology studies. Therefore, EC is mostly followed up to monitor any growth and/or changes indicating aggressive tumor. Read More

J Neurooncol 2020 Apr 18. Epub 2020 Apr 18.

Departments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Skull base primary malignancies represent a heterogeneous group of histologic diagnoses and sarcomas of the skull base are specific malignant tumors that arise from mesenchymal cells and can be classified by site of origin into bony and soft tissue sarcomas. The most common bony sarcomas include: chondrosarcoma, osteosarcoma, chordoma, Ewing's sarcoma. Given the relative rarity of each histologic diagnosis, especially in the skull base, there is limited published data to guide the management of patients with skull base sarcomas. Read More

Clin Orthop Relat Res 2020 Apr 14. Epub 2020 Apr 14.

R. Nakayama, N. Asano, Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan K. Hayakawa, Department of Orthopaedic Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan E. Kobayashi, Division of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan M. Endo, Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan T. Yonemoto, Department of Orthopaedic Surgery, Chiba Cancer Center, Chiba, Japan H. Kawashima, Department of Orthopaedic Surgery, Niigata University, Niigata, Japan K. Hamada, Department of Orthopaedic Surgery, Osaka University, Osaka, Japan I. Watanabe, Department of Orthopaedic Surgery, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan H. Futani, Department of Orthopaedic Surgery, Hyogo College of Medicine T. Goto, Department of Musculoskeletal Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital Y. Nishida, Department of Rehabilitation Medicine, Nagoya University, Aichi, Japan T. Ozaki, Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.

Background: Clear cell chondrosarcoma is an extremely rare chondrosarcoma subtype; thus, its treatment outcomes and associated factors have not been widely studied. Knowing more about it is potentially important because clear cell chondrosarcomas are often misdiagnosed as other benign lesions and subsequently treated and followed inappropriately.

Questions/purposes: (1) What are the patient- and tumor-related characteristics of clear cell chondrosarcoma? (2) What proportion of patients with clear cell chondrosarcoma initially had a misdiagnosis or a misleading initial biopsy result? (3) What is the survivorship of patients with clear cell chondrosarcoma free from death, local recurrence, and distant metastasis, and what factors are associated with greater survivorship or a reduced risk of local recurrence?

Methods: Between 1985 and 2018, 12 Japanese Musculoskeletal Oncology Group (JMOG) hospitals treated 42 patients with a diagnosis of clear cell chondrosarcoma. Read More

Nanomedicine 2020 Jul 8;27:102195. Epub 2020 Apr 8.

Advanced Medical Instrumentation Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Onna, Okinawa, Japan.

Treatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron capture therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with gadolinium for magnetic resonance imaging (MRI) in vivo. Read More

Orthopade 2020 Apr 7. Epub 2020 Apr 7.

General Hospital of Ningxia Medical University, 750004, Yinchuan, China.

This is a report of the reconstructive surgery of a patient with chondrosarcoma in the proximal radius. After extensive resection of the proximal radius that contained the tumor, the skeleton of the forearm was reconstructed by ulnar translocation. This patient was followed for 2 years, no recurrence of the tumor was found and the function of the forearm was nearly normal. Read More

J Surg Case Rep 2020 Mar 28;2020(3):rjaa037. Epub 2020 Mar 28.

Department of Pathology, Ospedale Universitario Santa Maria Della Misericordia, Udine, Italy.

Mesenchymal chondrosarcoma (MCS) is a rare high-grade sarcoma of bone and soft tissue with highly aggressive behavior and a peak incidence in the second and third decades. We report a case of primary orbital MCS in a 30 year-old female, with radiological and clinicopathological features. Orbital MCS is an entity that should be considered in the differential diagnosis of calcified orbital lesions. Read More

Magn Reson Imaging Clin N Am 2020 May;28(2):301-316

Department of Radiology, University of California San Diego, School of Medicine, UCSD Teleradiology and Education Center, 408 Dickinson Street, Mail Code #8226, San Diego, CA 92103-8226, USA.

This article discusses the most common tumor and tumor-like lesions arising at the shoulder. Osseous tumors of the shoulder rank second in incidence to those at the knee joint and include benign osteochondromas and myeloma or primary malignant lesions, such as osteosarcoma or chondrosarcomas. Soft tissue tumors are overwhelmingly benign, with lipomas predominating, although malignant lesions, such as liposarcomas, can occur. Read More

JBJS Case Connect 2020 Jan-Mar;10(1):e0324

Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal.

Case: A 60-year-old man presented with left hip pain, and a radiograph showed reduced joint space. During the surgical procedure for a total hip replacement, a proximal femur mass was identified and biopsy was subsequently interpreted as grade 2 chondrosarcoma. A wide resection was needed, but he developed local recurrence after 2 years and was treated with an external hemipelvectomy. Read More

Cancer Med 2020 Jun 27;9(11):3656-3667. Epub 2020 Mar 27.

Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.

The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however, little is known about soft tissue sarcoma (STS) regarding this matter. This study aimed to perform a time-lapse analysis of tumor response in patients with STS treated with trabectedin from 2 phase II clinical trials. We examined 66 patients with translocation-related sarcoma registered in 2 Japanese phase II clinical trials. Read More

Circ Cardiovasc Imaging 2020 Apr 25;13(4):e009824. Epub 2020 Mar 25.

Departments of Internal Medicine II (M.H., U.C.H., M.L.), Paracelsus Medical University, Salzburg, Austria.

EFORT Open Rev 2020 Feb 26;5(2):90-95. Epub 2020 Feb 26.

Department of Surgery, Tata Memorial Hospital, HBNI, Mumbai.

Chondrosarcomas in children and adolescents are uncommon and constitute < 5% of all chondrosarcomas. There are very few studies discussing extremity chondrosarcomas in young patients.The pelvis is the most common site, followed by the proximal femur. Read More

Skeletal Radiol 2020 Jul 9;49(7):1115-1125. Epub 2020 Mar 9.

Royal National Orthopaedic Hospital, London, UK.

Objective: To determine the reliability of image-guided core needle biopsy (IGCNB) for the diagnosis and grading of chondral tumours of bone compared with surgical histology.

Materials And Methods: Retrospective review of patients with a chondral tumour of bone who underwent IGCNB and surgical resection between January 2007 and December 2017. Data collected included age, sex, skeletal location, technique used for IGCNB, IGCNB result including histological grade and comparison with surgical histology. Read More

Anticancer Res 2020 Mar;40(3):1519-1526

Department of Orthopedics and Orthopedic Oncology, University of Padova, Padua, Italy

Background/aim: Chondrosarcomas (CS) of the chest wall are rare, but present an aggressive biological behavior compared to CS of the extremities. The aims of the present study were to determine factors associated with oncological outcomes as well as complications.

Patients And Methods: We retrospectively analyzed 53 patients (42 primary, 11 recurrent tumors). Read More

J Clin Imaging Sci 2020 15;10. Epub 2020 Feb 15.

Department of Radiology, University of Missouri, Columbia, Missouri.

Chondrosarcomas are tumors consisting of osseous or cartilaginous stroma. They are not an uncommon pathology; however, primary pulmonary chondrosarcomas arising in lung parenchyma are extremely rare, with few cases published in literature. Herein, we present a case with biopsy-proven primary pulmonary chondrosarcoma after exclusion of primary origin elsewhere. Read More

J Craniovertebr Junction Spine 2019 Oct-Dec;10(4):250-253. Epub 2020 Jan 23.

Department of Pathology, Seth GSMC, Mumbai, Maharashtra, India.

Chondrosarcomas of the spine are rare tumors and represent <10% of all chondrosarcomas. In the spine, they may arise from vertebral bodies or posterior elements. They may occur in patients ranging from 13 to 78 years of age. Read More

Eur J Radiol 2020 Apr 23;125:108846. Epub 2020 Jan 23.

Department of Orthopaedics, St. Vincent's Hospital, Melbourne, Victoria, Australia; Department of Surgery, St. Vincent's Hospital, Melbourne, Victoria, Australia.

Purpose: Distinguishing between enchondromas and low-grade (grade 1) chondrosarcomas can be challenging. The aim of this study was to investigate the role of Thallium-201 scintigraphy and Technetium-99 m pentavalent dimercaptosuccinic acid (Tc-99 m DMSA (V)) in the diagnosis and grading of chondrosarcomas.

Methods: 232 consecutive patients with pathologically proven cartilaginous tumours between the years 2000 and 2018 were evaluated. Read More

Anticancer Res 2020 Feb;40(2):1035-1039

Department of Orthopedic Oncology, The Cancer Institute Hospital of The Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant soft-tissue tumor and often shows extracompartmental tumoral invasion. The aim of our study was to investigate the clinical features, especially extracompartmental tumoral invasion (ETI) of EMC.

Patients And Methods: A total of 35 operative patients diagnosed with EMC were enrolled in this study from January 1980 to March 2018 in the Cancer Institute Hospital of The Japanese Foundation for Cancer Research. Read More

Lancet Oncol 2020 01 2;21(1):30-31. Epub 2020 Jan 2.

Medicine (Baltimore) 2020 Jan;99(5):e18643

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Introduction: Metastatic mesenchymal chondrosarcoma of the spine is a highly unusual disease without standard curative managements yet. The objective of this case report is to present a very rare case of metastatic chondrosarcoma to the spine successfully operated by surgical treatment. The management of these unique cases has yet to be well-documented. Read More

BMC Musculoskelet Disord 2020 Jan 29;21(1):53. Epub 2020 Jan 29.

Department of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, 200050, China.

Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an exceedingly rare subtype of low-grade central osteosarcoma (LGCO), accounting for up to 10% of cases and making it difficult to diagnose. CMF-OS is frequently misdiagnosed on a radiological examination and biopsy, even after the initial operation. Its treatment is a controversial issue due to its low-grade classification and actual high-grade behavior. Read More

Pathologe 2020 Mar;41(2):106-115

Knochentumor-Referenzzentrum, Institut für Pathologie, Universitätsspital Basel, Universität Basel, Schönbeinstrasse 40, Basel, 4031, Schweiz.

The integrative evaluation of histology and corresponding imaging is essential for the classification of bone tumors. Until a few years ago, there were hardly any molecular markers that could be used for diagnostic purposes. However, exome- and genome-wide sequencing analyses have since uncovered a number of tumor-specific aberrations that can be very helpful in ambiguous cases. Read More

Arch Argent Pediatr 2020 02;118(1):e34-e40

Servicio de Cirugía Ortopédica y Traumatología. Hospital Clínico Universitario-Malvarrosa, Valencia, España.

Synovial osteochondromatosis consists of a synovial metaplasia which affects 1 per 100 000 people. It is a very rare disease among children. It typically affects large joints of the body, especially the knee. Read More

Cureus 2019 Dec 6;11(12):e6308. Epub 2019 Dec 6.

Radiology, Quaid-e-Azam International Hospital, Islamabad, PAK.

Hereditary multiple osteochondromas (HMO) is an autosomal dominant disease diagnosed by the presence of two or more than two osteochondromas on radiographs. The majority of cases are asymptomatic. The presence of bony growth, pain, and compression of the surrounding structure are the usual presentations. Read More

Cas Lek Cesk 2019 ;158(6):248-252

Temporal bone tumors are rare entities. Histologically these pathologies represent heterogeneous group of diseases. The most common tumors of the temporal bone are vestibular schwannoma, tympanojugular paragangliomas and temporal bone carcinomas. Read More

Skeletal Radiol 2020 Jun 9;49(6):945-954. Epub 2020 Jan 9.

Department of Imaging, Royal National Orthopaedic Hospital, Stanmore, UK.

Introduction: Skip metastases have been described with osteosarcoma, Ewing sarcoma and rarely chondrosarcoma. The aim of this study was to determine the incidence of skip metastases on whole bone MRI in all primary high-grade sarcomas of the major long bones.

Materials And Method: Retrospective review of patients from April 2007 to April 2019 with high-grade primary bone sarcomas of the humerus, radius, ulna, femur, tibia or fibula who had whole bone MRI at initial staging. Read More

Acta Radiol Open 2019 Dec 11;8(12):2058460119892409. Epub 2019 Dec 11.

Department of Radiology, Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCLouvain), Brussels, Belgium.

We present the case of a 53-year-old woman with a known history of hereditary multiple exostosis disease referred for further imaging work-up after ultrasound and computed tomography leading to the suspicion of malignant transformation of an osteochondroma (exostosis) located on the posteromedial aspect of the right proximal femur. Imaging examinations suggested an ischiofemoral impingement resulting in a secondary bursitis associated with the development of an internal lipoma arborescens. This rare association explained the complexity of the diagnosis. Read More

Bone Joint J 2020 Jan;102-B(1):64-71

Royal Orthopaedic Hospital, Birmingham, UK.

Aims: The purpose of this study was to report the long-term results of extendable endoprostheses of the humerus in children after the resection of a bone sarcoma.

Methods: A total of 35 consecutive patients treated with extendable endoprosthetic replacement of the humerus in children were included. There were 17 boys and 18 girls in the series with a median age at the time of initial surgery of nine years (interquartile range (IQR) 7 to 11). Read More

Sarcoma 2019 29;2019:7385470. Epub 2019 Nov 29.

Department of Surgical Pathology, Tata Memorial Hospital, HBNI, Mumbai 400012, India.

In today's era, limb salvage surgery is the procedure of choice and current standard of care in appropriately selected patients of bone sarcomas. For adequate oncologic clearance, preoperative evaluation of the extent of tumor is mandatory. The present study was done to compare measurements of bone sarcomas (osteosarcoma, Ewing's sarcoma, and chondrosarcoma) as determined by magnetic resonance imaging (MRI) with the histopathological extent seen on resected specimens. Read More

Int J Hyperthermia 2019 ;36(1):1189-1195

Department of Radiotherapy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

To determine the size of the ablation zone after radiofrequency ablation (RFA) of atypical cartilaginous bone tumors (ACT) using temperature-controlled 20 and 30 mm RFA straight non-cooled electrodes. Sixteen patients with ACT in their long bones, who had undergone a single-session single-application CT-guided temperature-controlled RFA, were included retrospectively in the study. Tumors with a diameter of 10-25 mm were treated with 20 mm electrodes ( = 10), and tumors of 25-35 mm, with 30 mm electrodes ( = 6). Read More

Arch Pathol Lab Med 2020 01;144(1):71-82

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

Context.—: Cartilaginous tumors represent one of the most common tumors of bone. Management of these tumors includes observation, curettage, and surgical excision or resection, depending on their locations and whether they are benign or malignant. Read More

Medicine (Baltimore) 2019 Dec;98(50):e18413

Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Chondrosarcoma of the sacrum is a highly unusual disease without standard curative managements yet. The objective of this study is to report a very rare case of chondrosarcoma of the sacrum successfully operated by percutaneous vertebroplasty. The management of these unique cases has yet to be well-documented. Read More

BMJ Case Rep 2019 Dec 2;12(12). Epub 2019 Dec 2.

ENT and Head Neck Surgery, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India.

Chondrosarcomas of head and neck region are rare. Very few cases of chondrosarcomas arising in parotid gland have been reported and none with intracranial extension. We report a case of a female presenting with a parotid swelling and a mass in external auditory canal with extradural extension to posterior cranial fossa. Read More

J Bone Oncol 2019 Dec 31;19:100267. Epub 2019 Oct 31.

Musculoskeletal Oncology, Department of Orthopaedics, Physical Medicine and Rehabilitation, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, Germany.

Introduction: Clear cell chondrosarcoma (CCC) is a rare subtype of chondrosarcoma and it is commonly considered a low-grade tumor and less aggressive than atypical cartilaginous tumor (grade 1 central chondrosarcoma). However, the experience even of musculoskeletal tumor centres with this rare entity is limited. The aim of this study is to analyse our own treatment results and those of the literature regarding the therapy and outcome of this lesion. Read More

J Am Podiatr Med Assoc 2019 Nov;109(6):451-454

Soft-tissue chondroma is a rare, benign tumor. It is predominantly found in the hands and feet, but rarely in the toes. In this article, we report a digital soft-tissue chondroma that presented as a painful nodule of 5 years' duration in a 67-year-old man. Read More

Radiat Oncol 2019 Nov 21;14(1):206. Epub 2019 Nov 21.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, 4365 Kangxin Road, Shanghai, 201315, China.

Purpose: To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiation therapy.

Methods: Between 6/2014 and 7/2018, a total of 91 patients were treated in our Center. The median age was 38 (range, 4-70) years. Read More

Sarcoma 2019 13;2019:4878512. Epub 2019 Oct 13.

Department of Orthopaedic Surgery, Duke University Medical Center, 2301 Erwin Rd, Durham, NC 27710, USA.

Background: Although chondrosarcomas (CS) are mostly considered radioresistant, advancements in radiotherapy have brought attention to its use in these patients. Using the largest registry of primary bone tumors, the National Cancer Database (NCDB), we sought to better characterize the current use of radiotherapy in CS patients and identify any potential survival benefit with higher radiation doses and advanced radiation therapies.

Methods: We retrospectively analyzed CS patients in the NCDB from 2004 to 2015 who underwent radiotherapy. Read More

World Neurosurg 2020 Feb 14;134:e771-e782. Epub 2019 Nov 14.

Department of Neurosurgery, Lariboisière Hospital, Paris VII-Diderot University, Paris, France.

Background: Surgical management of extensive skull base tumors, such as chordoma and chondrosarcoma, remains very challenging. The need for gross total removal to improve survival must be weighed against the risk of injury to neurovascular structures and the loss of stability at the craniovertebral junction. In cases of tumors that are already compromising craniovertebral junction stability, the occipital condyle can be exploited as a deep keyhole to reach the clivus, petrous apex, and sphenoid sinus. Read More

Anticancer Res 2019 Nov;39(11):6223-6230

The Royal Marsden Hospital, London, U.K.

Background/aim: To describe imaging features of head and neck soft-tissue sarcomas.

Patients And Methods: Patients with a diagnosis of head and neck sarcoma between 2011 and 2015 were reviewed.

Results: There were a total of 62 patients (24 female; median age=60 years). Read More

Surg Oncol 2020 Mar 29;32:18-22. Epub 2019 Oct 29.

Massachusetts General Hospital, Harvard Medical School, Department of Orthopaedic Surgery, Musculoskeletal Oncology Service, 55 Fruit St., Boston, MA, 02114, USA. Electronic address:

Background: Osseous tumors of the shoulder girdle occur most frequently in the proximal humerus, scapula and clavicle. Prior studies have determined that tumors occurring in the scapula have a higher risk of malignancy, but few have looked exclusively at tumors of this site to describe incidence, clinical features and potential predictors of malignancy. As imaging technologies for diagnosis have improved, it is important to re-evaluate if patterns of incidence have changed and if new imaging findings could potentially be predictors of malignancy. Read More

Cureus 2019 Aug 30;11(8):e5537. Epub 2019 Aug 30.

Neurological Surgery, University of California, San Francisco, USA.

Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa component of a large ventral skull base chondrosarcoma, arterial bleeding was encountered near the right internal carotid artery (ICA). Durable hemostasis could not be achieved with packing and the patient was taken for an emergent angiogram that revealed a pseudoaneurysm of the proximal intradural ICA. Read More

J Bone Oncol 2019 Dec 25;19:100262. Epub 2019 Sep 25.

Department of Orthopaedics, St. Vincent's Hospital, Melbourne VIC, Australia.

Introduction: The distinction between low-grade (grade 1) chondrosarcoma and its benign counterparts can be challenging. This systematic review aims to quantify the diagnostic accuracies of all functional imaging modalities used in the diagnosis of chondrosarcoma.

Methods: Medline and Embase were searched in February 2019. Read More