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Medicine (Baltimore) 2019 Apr;98(15):e15207

Department of Orthopedic Surgery, Al Hussein Salt Hospital, Ministry of Health, Al-Salt, Jordan.

Rationale: Extraskeletal myxoid chondrosarcoma is a slow-growing soft tissue tumor of adults with a propensity for local recurrence and eventual metastasis. Only 17 pediatric and adolescent cases have been reported.

Patient Concerns: Here we present an 11-year-old boy with a 3-year history of a slowly growing painless left leg mass. Read More

Braz J Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Erciyes University Medical Faculty, Department of Radiology, Kayseri, Turkey.

Introduction: Squamous cell carcinoma is the most common laryngeal neoplasm and accounts for approximately 95% of all malignant neoplams of the larynx. However, various benign and malignant tumors and inflammatory diseases may affect the larynx.

Objective: The purpose of this study is to analyze the clinical and imaging findings of non-squamous cell neoplasms and inflammatory diseases of the larynx. Read More

Indian J Surg Oncol 2019 Mar 8;10(1):107-114. Epub 2018 Dec 8.

1Department of Orthopaedic Surgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Sacral tumors are amongst the most challenging procedures to treat because of the complex anatomy. This study determined whether patient-specific models change preoperative planning decisions made in preparation for en bloc resection of complex sacral mass surgical procedures. Imaging showed a big encapsulated mass at the S2-3 level involving the neural foramina and obscuring the nerve roots. Read More

Case Rep Otolaryngol 2019 17;2019:7170832. Epub 2019 Feb 17.

18 March University, Medical School, Otorhinolaryngology Department, Çanakkale, Turkey.

We describe a case of a 31-year-old woman with a chondrosarcoma of the hyoid bone. The patient presented with a mass in the left submandibular region. Fine-needle aspiration cytology suggested chondroma, but further imaging investigation with CT revealed an exophytic tumor originating from the body of the hyoid bone. Read More

J Belg Soc Radiol 2018 Sep 6;102(1):56. Epub 2018 Sep 6.

Institut Kassab of Orthopaedics, TN.

Primary malignant tumors of the spine are rare and mainly include chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma. The final diagnosis is based on the combination of patient age, topographic and histologic features of the tumor, and lesion pattern on computed tomography (CT) and magnetic resonance (MR) imaging. Imaging evaluation includes radiography, CT, bone scintigraphy, and MR imaging. Read More

J Orthop Case Rep 2018 Nov-Dec;8(6):50-53

Department of Radiology, Cardarelli Hospital, via A. Cardarelli 9, 80131, Napoli, Italy.

Introduction: Impingement syndrome is one of the most common pain disorders of the shoulder; it may be due by structural alteration of acromion, coracoacromial ligament, acromioclavicular joint, biceps tendon, or coracoid process; however, in rare cases, impingement syndrome may be due also by benign tumors such as osteochondroma.

Case Report: We presented a case of 27-year-old male with clavicular impingement syndrome secondary to osteochondroma. He received conservative treatment before the diagnosis of the osteochondroma. Read More

Ren Fail 2019 Nov;41(1):98-103

a Department of Urology , The First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi Province , China.

As an extremely rare malignant neoplasm, only 12 mesenchymal chondrosarcoma (MC) arising in kidney have been reported to date. Herein, we reported a case of primary renal MC resected with robot assistance, which has not been reported before. According to the cases reported in English literature, we analyzed the characteristics of this rare malignancy and systematically review its treatment. Read More

Eklem Hastalik Cerrahisi 2019 Apr;30(1):24-31

Department of Orthopedics and Traumatology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, 06200, Demetevler, Ankara, Turkey.

Objectives: This study aims to evaluate the clinical characteristics and treatment outcomes of patients with primary malignant tumors located in the proximal fibula.

Patients And Methods: This retrospective study included 23 patients (15 males, 8 females; mean age 22.1 years; range, 9 to 63 years) with primary malignant tumors located in the proximal fibula between May 2007 and May 2017. Read More

World Neurosurg 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurosurgery, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Chengdu, Sichuan, 610041, P.R China. Electronic address:

Background: Ollier disease (OD) is a rare, nonhereditary bone disease that is characterized by the presence of multiple enchondromatosis (3 or more) with a typical asymmetrical distribution and mainly confined to the appendicular skeleton. Ollier disease's most serious complication is the transformation of an enchondroma into chondrosarcoma. The most common sites for chondrosarcoma are in the pelvic and shoulder bones, the superior metaphyseal and diaphyseal regions of the extremities. Read More

Clin Radiol 2019 Feb 28. Epub 2019 Feb 28.

The Department of Radiology, The Royal Orthopaedic Hospital, Bristol Road South, Birmingham B31 2AP, UK.

Central cartilage tumours of bone range from the benign enchondroma to the malignant chondrosarcoma. They are an incidental finding in up to 2.8% of routine magnetic resonance imaging (MRI) examinations performed of the shoulder and knee. Read More

Int J Surg Case Rep 2019 14;56:37-39. Epub 2019 Feb 14.

Department of Surgical Oncologists, Salah-Azaiez Institute, Boulevard of 9-Avril, 1001 Tunis, Tunisia.

Introduction: Chondrosarcoma (CS) was the third most common primary bone malignancy. Frequently chondrosarcoma was occurring in long bones or in the pelvis. Their localization in the rib is rare. Read More

Cell Commun Signal 2019 02 26;17(1):17. Epub 2019 Feb 26.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Background: Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used clinically under FDA approval for application in cancer therapeutic remedies. However, the level of CDK4 and the treatment possibility in chondrosarcoma require further exploration. Read More

J Bone Oncol 2019 Apr 29;15:100222. Epub 2019 Jan 29.

Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.

Background: Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in chondrosarcoma.

Methods: A custom-designed metabolic compound screen containing 39 compounds targeting different metabolic pathways was performed in chondrosarcoma cell lines JJ012, SW1353 and CH2879. Read More

J Hand Surg Asian Pac Vol 2019 Mar;24(1):45-49

‡ Division of Trauma, Department of Orthopedic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Background: Primary malignant tumours of the hand are extremely rare, with chondrosarcoma being the most common. We describe six consecutive cases of chondrosarcoma (CS) of the hand, with a follow-up of 12 months to 10 years after surgical intervention.

Methods: Five cases were primary tumors and one was secondary to Ollier's disease. Read More

J Maxillofac Oral Surg 2019 Mar 15;18(1):46-51. Epub 2017 Dec 15.

Department of Oral and Maxillofacial Pathology, Tamil Nadu Government Dental College and Hospital, The Tamil Nadu Dr. MGR Medical University, Chennai, 600 003 India.

Cartilage analogue of fibromatosis is a relatively common tumor in the palms and soles of young children and adolescence. The characteristic histological finding of the tumor is the differentiation toward cartilage formation within a background of fibromatosis-like growth. Therefore, the tumor may cause potential diagnostic problems in the maxillofacial bones where it has not been described. Read More

Skeletal Radiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiology and Department of Orthopedics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Synovial chondromatosis is an uncommon benign neoplasm that usually affects large appendicular joints and only rarely the spine. There are only a few small series and case reports documenting malignant transformation of synovial chondromatosis into secondary chondrosarcoma, typically within the hip in the setting of recalcitrant disease and multiple recurrences. Chondrosarcoma arising in synovial chondromatosis of the spine is exceedingly rare, with only one previously published case report involving the craniocervical junction. Read More

Semin Musculoskelet Radiol 2019 Feb 30;23(1):3-18. Epub 2019 Jan 30.

Unidad de Diagnóstico por Imagen, Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Chondroid tumors are a heterogeneous group of neoplasms that all share the production of chondroid matrix. This ranges from a fetal type to mature hyaline cartilage and mirrors its imaging characteristics.The benign chondroid tumors represent some of the most encountered incidental bone lesions, with osteochondroma the most frequent benign bone tumor. Read More

Acta Oncol 2019 Mar 11;58(3):273-282. Epub 2019 Jan 11.

a Division of Orthopaedic Surgery , Oslo University Hospital , Oslo , Norway.

Background: Knowledge of chondrosarcoma (CS) of bone to date is based on institutional reports and registry publications with limits in reporting, detail and quality of data.

Method: We have performed a retrospective search of CS of bone in the National Cancer Registry in Norway from 1990-2013, cross checked against local tumor databases with further quality control and supplementation of all data from clinical files. The time period is defined by the routine use of axial imaging in clinical practice. Read More

BMJ Case Rep 2018 Dec 31;11(1). Epub 2018 Dec 31.

General Surgery, Helios Klinikum Berlin-Buch, Berlin, Germany.

The mesenchymal chondrosarcoma (MC) is a rare malignant tumour and accounts for less than 3% of primary chondrosarcomas. Mostly MC arises from the craniofacial bones, the ribs, the ilium, the femur and the vertebrae. A 54-year-old man was treated due to an icterus of unknown origin. Read More

J Bone Oncol 2018 Nov 4;13:114-122. Epub 2018 Oct 4.

Department of Orthopaedic Surgery, First affiliated Hospital of Tsinghua University, Beijing, 100016, China.

Background: The most serious complication of hereditary multiple exostoses(HME) is chondrosarcoma transformation. Numerous authors have suggested that screening might allow early chondrosarcoma detection. However, literature-quoted incidences of malignant transformation are highly variable. Read More

J Stomatol Oral Maxillofac Surg 2018 Dec 14. Epub 2018 Dec 14.

Service de stomatologie et chirurgie maxillo-faciale, AP-HP, DHU FAST, GH Pitié-Salpêtrière, Charles-Foix, 75013, Paris, France; Sorbonne universités, UPMC Université Paris 06, UMR 8256 B2A, 75005, Paris, France.

Objective: We had for aim to study the clinical manifestations, diagnostic imaging techniques, histopathological and therapeutic findings of patients presenting with synovial chondromatosis (CS) of the temporomandibular joint (TMJ).

Material And Methods: We reviewed the clinical history of all our patients who were diagnosed with CS between 2009 and 2013.

Results: We identified 12 cases of TMJ-CS, in 4 male and 8 female patients, with a mean aged of 50. Read More

Pathologica 2018 Sep;110(2):103-105

Department of Pathology, Habib Bourguiba University Hospital, 3029, Sfax, Tunisia.

Extraskeletal chondrosarcoma is a rare malignant tumor. The well differentiated histological type, which is found primary in soft tissue, is extremely rare. This report  describes the case of a 58-year-old woman presented with a large palpable mass in the right buttock. Read More

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Department of Medical Genetics and Rare Orthopaedic Diseases & CLIBI Laboratory-IRCCS, Istituto Ortopedico Rizzoli, V. di Barbiano 1/10, 40136 Bologna, Italy.

Multiple osteochondromas (MO) is a hereditary disorder associated with benign cartilaginous tumors, known to be characterized by absence or highly reduced amount of heparan sulfate (HS) in the extracellular matrix of growth plate cartilage, which alters proper signaling networks leading to improper bone growth. Although recent studies demonstrated accumulation of HS in the cytoplasm of MO chondrocytes, nothing is known on the structural alterations which prevent HS from undergoing its physiologic pathway. In this work, osteochondroma (OC), peripheral chondrosarcoma, and healthy cartilaginous human samples were processed following a procedure previously set up to structurally characterize and compare HS from pathologic and physiologic conditions, and to examine the phenotypic differences that arise in the presence of either exostosin 1 or 2 ( or ) mutations. Read More

Clin Nucl Med 2019 Feb;44(2):173-175

A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. Read More

Skeletal Radiol 2019 May 29;48(5):823-830. Epub 2018 Nov 29.

Department of Musculoskeletal Radiology, NYU Langone Health, New York, NY, USA.

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that typically occurs in young adults. Juxtacortical or surface-type CMF are rarer still and we present the case of a surface-type CMF in a 78-year-old woman, with only one other case described in a patient of a similar age previously. This patient was an otherwise healthy woman who presented for evaluation of a palpable lump in the anterior proximal tibia. Read More

J Neurol Surg Rep 2018 Oct 18;79(4):e83-e87. Epub 2018 Oct 18.

Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, Canada.

 Surgical treatment of petrous apex chondrosarcoma is challenging due to the location of the tumor. Using an endoscopic technique for tumor resection is favored since it provides a minimally invasive approach.  A 57 years old female was admitted for acute onset of left abducens nerve palsy and occasional headache mainly on the left side of the retro-orbital area with some radiation to the left occiput. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13282

Department of Maxillofacial Surgery, the Hospital of Stomatology, Jilin University, Changchun, China.

Rationale: This paper describes the application of individual customized 3-dimensional (3D) printed macro-porous Ti6Al4 V shoulder prosthesis in the revision of total shoulder arthroplasty (TSA) for the patient with severe bone defects.

Patient Concerns: A 47-year-old male had been under proximal humeral resection and TSA due to shoulder chondrosarcoma 6 years ago, but a second surgery to insert a new prosthesis was then performed because the prosthesis became loose 2 months ago leaving severe bone defects which conventional prosthesis was not suitable for revision of TSA. American Shoulder and Elbow Surgeons' Form (ASES), Neer and Constant-Murley score were 36, 39, and 39, respectively. Read More

World Neurosurg 2019 Feb 9;122:e1078-e1082. Epub 2018 Nov 9.

Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China. Electronic address:

Objective: To report differences in clinical features and outcomes between intracranial mesenchymal chondrosarcoma (MCS) and conventional chondrosarcoma (CCS).

Methods: Clinical data of patients with primary intracranial MCS and CCS were retrospectively extracted and analyzed to compare differences between MCS and CCS.

Results: Seventy-four patients with intracranial chondrosarcoma (61 cases with MCS and 13 cases with CCS) were included. Read More

Skeletal Radiol 2019 Apr 29;48(4):643-647. Epub 2018 Oct 29.

Department of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

We herein report a rare case of mesenchymal hamartoma of the chest wall in a 10-year-old girl. She complained of chest pain and was diagnosed with a large chest wall tumor originating from the left fourth rib. Malignancy such as osteosarcoma or chondrosarcoma could not be ruled out with imaging studies. Read More

BMC Cancer 2018 Oct 24;18(1):1036. Epub 2018 Oct 24.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Background: Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimensional osteotomy is difficult particularly around the acetabulum. Additionally, removal of the joint makes reconstruction very difficult; thus, retention of good function also becomes difficult. In musculoskeletal oncology, computer navigation systems are still not widely used to prevent tumor-positive margins. Read More

Int J Spine Surg 2018 Jan 30;12(1):43-48. Epub 2018 Mar 30.

Spine Department, Star Hospitals, Road No. 10, Banjara Hills, Hyderabad, Telangana, India.

Background: Enchondroma protuberans (EP) is rare, benign cartilaginous bone tumor arising from the intramedullary cavity of long bones and usually protrudes beyond the cortex with an exophytic growth pattern resembling osteochondroma. This study reports on a rare case of EP arising from the transverse process of the D8 vertebra and extending to the adjacent 7th and 8th ribs and the paraspinal tissues.

Methods: A 45-year-old female patient came in with complaints of upper back pain radiating up to the left costal margin for the past 6 months. Read More

Asian Cardiovasc Thorac Ann 2018 Oct 30;26(8):632-634. Epub 2018 Sep 30.

Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

A 75-year-old man presented very late with a huge sternal mass that measured 91 × 84 mm on computed tomography. A core needle biopsy revealed atypical cartilage tissue, suggesting chondrosarcoma. The mass was resected and the defect was reconstructed with bone cement, Prolene mesh, and a muscle flap. Read More

World Neurosurg 2018 Oct 3;118:279-283. Epub 2018 Jul 3.

Departments of Neurosurgery, National Institute of Neurology Tunis, Tunisia Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Background: Primary intracranial chondrosarcoma is an extremely rare malignant tumor of the central nervous system, which accounts for <0.16% of all primary intracranial tumors. This rare tumor has a high associated morbidity from the tumor itself as well as from treatment modalities. Read More

World Neurosurg 2018 Dec 19;120:e1234-e1244. Epub 2018 Sep 19.

Department of Neurological Surgery, Wexner Medical Center at The Ohio State University, Columbus, Ohio, USA; Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at The Ohio State University, Columbus, Ohio, USA. Electronic address:

Background/objective: The inframeatal area represents a challenging region for skull base surgeons. Various surgical corridors have been described to access this area and frequently are used in combination. Recent studies describe the expanded endoscopic endonasal approach (EEA) as an established route for midline regions, particularly medial to the internal carotid arteries (ICA). Read More

PET Clin 2018 Oct 17;13(4):623-634. Epub 2018 Aug 17.

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.

Primary bone malignancies are characterized with anatomic imaging. However, in recent years, there has been an increased interest in PET/computed tomography scanning and PET/MRI with fludeoxyglucose F 18 for evaluating and staging musculoskeletal neoplasms. These hybrid imaging modalities have shown promise largely owing to their high sensitivity, ability to perform more thorough staging, and ability to monitor treatment response. Read More

Surg Oncol 2018 Sep 6;27(3):402-408. Epub 2018 May 6.

Department of Orthopaedic Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands. Electronic address:

Background: There are few studies detailing the incidence, patient outcomes and prognostic factors for chondrosarcomas (CS). Those that do exist have small sample sizes and/or use older datasets. The purpose of this study was to determine the incidence, overall survival (OS) and prognostic factors for OS of CS patients, as well as investigate the efficacy of curettage. Read More

World Neurosurg 2018 Dec 8;120:234-239. Epub 2018 Sep 8.

Department of Neurosurgery, First Hospital of Jilin University, Changchun, China. Electronic address:

Background: Intracranial nonskull-based chondrosarcoma is a very rare malignant tumor. In fact, it is difficult to diagnose because of its atypical radiologic and morphologic features. We report a case of an intracranial parasagittal chondrosarcoma in the left parietal lobe accompanied with significant peritumoral edema (an extremely rare phenomenon for this tumor), with a review of the literature, to clarify aspects in the diagnosis of this rare tumor. Read More

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

Chondrosarcomas represent a group of malignant tumours composed of cells producing cartilage, and clear cell chondrosarcomas (CCC) represent a variant of these. A rare case of a laryngeal CCC is presented. The patient was a 70-year-old man who presented with a 6-week history of throat pain, worsening dysphonia and a lump in the neck. Read More

Ortop Traumatol Rehabil 2018 Feb;20(1):65-70

Klinika Ortopedii i Traumatologii USK w Białymstoku, Polska, Zakład Patomorfologii Lekarskiej UM w Białymstoku, Polska.

The article describes epidemiology, clinical features and treatment strategy of chondrosarcoma with special regard to diagnostic and therapeutic difficulties in low grade chondrosarcomas. Chondrosarcomas account for 3.5-9% of primary bone tumors and approximately 30% of primary bone malignancies. Read More

Orthop Surg 2018 Aug;10(3):272-275

Tianjin Hospital, Tianjin University, Tianjin, China.

The clinical incidence of tumors in the manubrium is not high. Regardless of whether the tumor is primary or metastatic, the tumor should be completely removed as long as the patient is able to tolerate the surgery. This procedure can lead to sternal defects. Read More

Indian J Cancer 2018 Jan-Mar;55(1):37-44

Department of Surgical Pathology, Bone and Soft Tissues, Disease Management Group (DMG), Tata Memorial Hospital, Mumbai, Maharashtra, India.

Introduction: Primary bone and soft tissue sarcomas are rare, but diagnostically and therapeutically challenging group of tumors, requiring multidisciplinary management. There are limited documented studies from multidisciplinary teams , in the form of comprehensive analysis of these tumors, from our country. This study is an analysis of cases of osteosarcomas, Ewing sarcomas (ESs), chondrosarcomas (CSs), and soft-tissue sarcomas (STSs), registered at our institution during 2012. Read More

Med Oncol 2018 Aug 16;35(10):126. Epub 2018 Aug 16.

Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, 01-211 Warszawa, ul. Kasprzaka 17a, Warsaw, Poland.

Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Read More

Clin Sarcoma Res 2018 9;8. Epub 2018 Apr 9.

1Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, Oxford, OX3 7LE UK.

Background: The use of F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Read More

Cureus 2018 May 30;10(5):e2709. Epub 2018 May 30.

Hematology and Oncology, Joan C. Edwards School of Medicine at Marshall University, Huntington, USA.

Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma with an indolent course and poor response to systemic treatment. We present a case of a 53-year-old male who presented with right gluteal extraskeletal myxoid chondrosarcoma. He was treated with wide local excision after receiving 50 Gray of neoadjuvant radiation therapy. Read More

World Neurosurg 2018 Nov 17;119:e32-e45. Epub 2018 Jul 17.

Division of Neurosurgery, Banner University of Arizona Medical Center Tucson, Tucson, Arizona, USA. Electronic address:

Background: Only a few case reports and case series exist reporting on primary chondrosarcomas of the spine. The objective of this study was to gain a better understanding of this patient population and surgical techniques used for treatment.

Methods: A systematic literature search was performed in January 2018 querying several scientific databases, per PRISMA guidelines. Read More

Eur J Radiol 2018 Aug 29;105:119-124. Epub 2018 May 29.

Department of Radiooncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Ion Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Purpose: To determine the diagnostic accuracy of DW MR imaging with apparent diffusion coefficient (ADC) mapping for the distinction of skull base chordoma from skull base chondrosarcoma.

Patients And Methods: From October 2009 to April 2014, 105 consecutive patients (chordomas (n = 70), and chondrosarcomas (n = 35) who were planned to receive proton or heavy-ion beam therapy underwent DW MR imaging on a 3.0 T. Read More

Front Neurol 2018 26;9:502. Epub 2018 Jun 26.

Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.

Here we present a 75-year-old patient who was admitted with acute-onset right-sided hemiparesis, dysphagia, dysarthria and nystagmus. Repeated MRI scans showed two lesions with contact to one another: one solid stationary extra-axial lesion at the caudal part of the clivus and a rapidly growing intra-axial cystic lesion at the level of the medulla oblongata. Biopsy of the solid lesion demonstrated a low-grade chondrosarcoma, while no tissue sample of the cystic lesion could be retrieved. Read More

Medicine (Baltimore) 2018 Jul;97(27):e11274

Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.

Rationale: Intracranial chondrosarcomas are rare entities and most of which arise off the midline. Chondrosarcomas that occur in the sellar region are extremely rare, and to the best of our knowledge, there is no reporting about sellar chondrosarcoma with amenorrhea as the onset symptom.

Patient Concerns: A 45-year-old woman presented with a 7-month history of amenorrhea and a 3-month history of progressive visual loss in the left eye. Read More

Biomed Res Int 2018 7;2018:9684268. Epub 2018 Jun 7.

Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

The purpose of this study was to achieve better understanding of extraskeletal myxoid chondrosarcoma (EMC). 13 cases of EMC confirmed by surgery biopsy were retrospectively studied. All patients underwent preoperative CT or/and MRI examinations. Read More