8,920 results match your criteria Chondrosarcoma Imaging


Deep integrative analysis of microRNA-mRNA regulatory networks for biomarker and target discovery in chondrosarcoma.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Joint Surgery, The Affiliated Hospital of Jining Medical University, Shandong, China.

Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largely unknown. Read More

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December 2018

Chondrosarcoma: biology, genetics, and epigenetics.

Authors:
Warren A Chow

F1000Res 2018 20;7. Epub 2018 Nov 20.

Department of Medical Oncology & Therapeutics Research, City of Hope, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.

Chondrosarcomas constitute a heterogeneous group of primary bone cancers characterized by hyaline cartilaginous neoplastic tissue. They are the second most common primary bone malignancy. The vast majority of chondrosarcomas are conventional chondrosarcomas, and most conventional chondrosarcomas are low- to intermediate-grade tumors (grade 1 or 2) which have indolent clinical behavior and low metastatic potential. Read More

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November 2018
2 Reads

Unusual Focal Muscle FDG Activity Related to Altered Biomechanics.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. Read More

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December 2018

Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review.

Skeletal Radiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Musculoskeletal Radiology, NYU Langone Health, New York, NY, USA.

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that typically occurs in young adults. Juxtacortical or surface-type CMF are rarer still and we present the case of a surface-type CMF in a 78-year-old woman, with only one other case described in a patient of a similar age previously. This patient was an otherwise healthy woman who presented for evaluation of a palpable lump in the anterior proximal tibia. Read More

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November 2018

Mesenchymal chondrosarcoma of the parapharyngeal space.

J Cancer Res Ther 2018 Oct-Dec;14(6):1446-1448

Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

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November 2018

Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.

Lancet Oncol 2018 Nov 23. Epub 2018 Nov 23.

Medical Oncology Department, Centre Léon Bérard, Lyon, France.

Background: Regorafenib has proven activity in patients with pretreated gastrointestinal stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to assess the efficacy and safety of regorafenib for patients with progressive metastatic osteosarcoma and other bone sarcomas. This trial comprised four parallel independent cohorts: osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. Read More

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November 2018
2 Reads

Chondrosarcoma in the Petrous Apex: Case Report and Review.

J Neurol Surg Rep 2018 Oct 18;79(4):e83-e87. Epub 2018 Oct 18.

Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, Canada.

 Surgical treatment of petrous apex chondrosarcoma is challenging due to the location of the tumor. Using an endoscopic technique for tumor resection is favored since it provides a minimally invasive approach.  A 57 years old female was admitted for acute onset of left abducens nerve palsy and occasional headache mainly on the left side of the retro-orbital area with some radiation to the left occiput. Read More

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October 2018
3 Reads

Correction: Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells.

Oncotarget 2018 Oct 30;9(85):35598. Epub 2018 Oct 30.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

[This corrects the article DOI: 10.18632/oncotarget.2724. Read More

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October 2018
3 Reads

Baicalin Induces Apoptotic Death of Human Chondrosarcoma Cells through Mitochondrial Dysfunction and Downregulation of the PI3K/Akt/mTOR Pathway.

Planta Med 2018 Nov 23. Epub 2018 Nov 23.

Department of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

The aim of the present study was to investigate the cytotoxic and antitumour effects of baicalin in human chondrosarcoma both and . We examined the effects of baicalin on the growth and apoptosis of human chondrosarcoma cells. Baicalin inhibited the growth of SW1353 and CH2879 cells in a dose- and time-dependent manner, but did not inhibit the growth of normal chondrocytes. Read More

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November 2018
2 Reads

Co-signaling receptors regulate T-cell plasticity and immune tolerance.

Front Biosci (Landmark Ed) 2019 01 1;24:96-132. Epub 2019 Jan 1.

Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, U.S.A.

We took an experimental database mining analysis to determine the expression of 28 co-signaling receptors in 32 human tissues in physiological/pathological conditions. We made the following significant findings: co-signaling receptors are differentially expressed in tissues; heart, trachea, kidney, mammary gland and muscle express co-signaling receptors that mediate CD4T cell functions such as priming, differentiation, effector, and memory; urinary tumor, germ cell tumor, leukemia and chondrosarcoma express high levels of co-signaling receptors for T cell activation; expression of inflammasome components are correlated with the expression of co-signaling receptors; CD40, SLAM, CD80 are differentially expressed in leukocytes from patients with trauma, bacterial infections, polarized macrophages and in activated endothelial cells; forward and reverse signaling of 50% co-inhibition receptors are upregulated in endothelial cells during inflammation; and STAT1 deficiency in T cells upregulates MHC class II and co-stimulation receptors. Our results have provided novel insights into co-signaling receptors as physiological regulators and potentiate identification of new therapeutic targets for the treatment of sterile inflammatory disorders. Read More

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January 2019
1 Read

Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway.

Biomol Ther (Seoul) 2018 Nov;26(6):560-567

Department of Orthopaedic Surgery, Institute of Health Sciences, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea.

In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B (NF-κB) in articular chondrocytes. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-1β (IL-1β)-induced gene expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), ADAMTS-5 and type II collagen. Effect of resveratrol on IL-1β-induced secretion of MMP-3 was investigated in rabbit articular chondrocytes using western blot analysis. Read More

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November 2018
1 Read

Novel exploration of customized 3D printed shoulder prosthesis in revision of total shoulder arthroplasty: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13282

Department of Maxillofacial Surgery, the Hospital of Stomatology, Jilin University, Changchun, China.

Rationale: This paper describes the application of individual customized 3-dimensional (3D) printed macro-porous Ti6Al4 V shoulder prosthesis in the revision of total shoulder arthroplasty (TSA) for the patient with severe bone defects.

Patient Concerns: A 47-year-old male had been under proximal humeral resection and TSA due to shoulder chondrosarcoma 6 years ago, but a second surgery to insert a new prosthesis was then performed because the prosthesis became loose 2 months ago leaving severe bone defects which conventional prosthesis was not suitable for revision of TSA. American Shoulder and Elbow Surgeons' Form (ASES), Neer and Constant-Murley score were 36, 39, and 39, respectively. Read More

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November 2018
1 Read

Invasive nasal histiocytic sarcoma as a cause of epilepsy .

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918811179. Epub 2018 Nov 8.

Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals, Utrecht University, The Netherlands.

Case Summary: A 10-year-old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of a right-sided forebrain lesion, temporal lobe epilepsy and generalised seizure activity. MRI of the head revealed an expansile soft tissue mass in the caudal nasal passages (both sides but predominantly right-sided) involving the ethmoid bone and extending through the cribriform plate into the cranial vault affecting predominantly the right frontal lobe and temporal lobe. Histopathological examination of the tumour revealed a histiocytic sarcoma. Read More

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November 2018

Variations in contents of hyaluronan in the peritumoral micro-environment of human chondrosarcoma.

J Orthop Res 2018 Nov 15. Epub 2018 Nov 15.

Department of Neuroscience, Anatomy Institute, University of Padova, via Gabelli 65, Padova 35121, Italy.

A concept consolidated in recent years is that tumor growth depends to a great extent on the micro-environment surrounding the tumor, which has a fundamental role in tumor progression and in determining the effectiveness of therapies. Our analysis focuses on chondrosarcoma, the second primary malignant bone tumor, resistant to both chemotherapeutic and radiation therapy. We quantified hyaluronan, one of the main components of the extracellular matrix, with the aim of comparing its amount in the connective tissue surrounding the tumor with intra-tumoral tissue and healthy fascia of the same anatomic district, viewed as a health control. Read More

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November 2018
3 Reads

FOXA1 transcriptionally up-regulates cyclin B1 expression to enhance chondrosarcoma progression.

Am J Cancer Res 2018 1;8(10):1989-2004. Epub 2018 Oct 1.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University Taichung 40402, Taiwan.

Chondrosarcoma is a malignant and common bone tumor that is highly resistant to radiation and chemotherapy. At this moment, amputation surgery is the only option which unfortunately has serious impact to daily lives of the patients. Thus, there is an urgent need to understand causative molecular mechanisms underlying the disease for more accurate prognosis and more effective targeted treatment. Read More

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October 2018
2 Reads

The Differences between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes.

World Neurosurg 2018 Nov 8. Epub 2018 Nov 8.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: The goal of this study is to report the differences in clinical feature and outcomes between intracranial MCS (mesenchymal chondrosarcoma) and CCS (conventional chondrosarcoma).

Methods: Clinical data of patients with primary intracranial MCS and CCS were retrospectively extracted and analyzed to compare the differences between each other.

Results: Seventy-four patients with intracranial chondrosarcoma (61 cases with MCS and 13 cases with CCS) were included. Read More

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November 2018

Extraskeletal Mesenchymal Chondrosarcoma.

Arch Pathol Lab Med 2018 Nov;142(11):1421-1424

From the Department of Pathology, University of Texas Health Science Center, San Antonio. Dr Arora is now with the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas. Dr Riddle is now with the Department of Pathology, Cunningham Pathology, Birmingham, Alabama.

Extraskeletal mesenchymal chondrosarcoma is a rare soft tissue sarcoma arising from soft tissues, mainly of the lower extremities, meninges, and orbits. It usually presents during the second to third decades of life, and has a slight predominance in females. Histologically, it has a typical biphasic pattern comprising small cells and islands of hyaline cartilage. Read More

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November 2018

Bone chondrosarcomas: clinical features and surgical outcomes in five years

Rev Med Inst Mex Seguro Soc 2018 Oct 25;56(3):273-278. Epub 2018 Oct 25.

Instituto Mexicano del Seguro Social, Centro Médico Nacional de Occidente, Hospital de Especialidades, Unidad de Investigación Biomédica 02. Guadalajara, Jalisco, México

Background: Biological and clinical behavior of chondrosarcoma, and its prognosis, are broadly related to histological grade, location and treatment. Surgery plays the most important role in local control and preservation of the limb. Given its low incidence, there are few cancer surgical centers in our country that report their experience concerning the treatment of this pathology. Read More

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October 2018
4 Reads

Surgical therapy of benign and low-grade malignant intramedullary chondroid lesions of the distal femur: intralesional resection and bone cement filling with or without osteosynthesis.

Strategies Trauma Limb Reconstr 2018 Nov 3;13(3):163-170. Epub 2018 Nov 3.

Center of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.

Surgical treatment of benign and low-grade malignant intramedullary chondroid lesions at the distal femur is not well analyzed compared to higher-grade chondrosarcomas. Localization at the distal femur offers high biomechanical risks requiring sophisticated treatment strategy, but scientific guidelines are missing. We therefore wanted to analyze a series of equally treated patients with intralesional resection and bone cement filling with and without additional osteosynthesis. Read More

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November 2018
7 Reads

Prognostic value of Kindlin-2 expression in patients with solid tumors: a meta-analysis.

Cancer Cell Int 2018 22;18:166. Epub 2018 Oct 22.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.

Background: Kindlin-2 is one of the Kindlin family members which are evolutionarily conserved focal adhesion proteins with integrin β-binding affinity. Recently, accumulative studies have suggested that Kindlin-2 plays important roles in tumor biology. However, the prognostic significance of Kindlin-2 in patients with solid tumors remains controversial. Read More

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October 2018
2 Reads

Sarcomas of the Oral and Maxillofacial Region: Analysis of 26 Cases with Emphasis on Diagnostic Challenges.

Pathol Oncol Res 2018 Oct 31. Epub 2018 Oct 31.

Department of Oral Medicine & Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Sarcomas of the Oral and Maxillofacial Region (SOMR) are rare lesions which pose diagnostic and management challenges. We analyzed 26 cases of SOMR with respect to clinical presentation, histopathological subtype, treatment modalities, recurrence, and treatment outcome. In our series, Osteosarcoma (OS) was the most common type of sarcoma (7 cases), followed by 5 cases of Ewing's Sarcoma (ES), 3 cases each of Chondrosarcoma (CS) and Leiomyosarcoma (LMS), 2 cases each of Malignant Peripheral Nerve Sheath Tumor (MPNST), Pleomorphic Undifferentiated Sarcoma (PUS), Myeloid Sarcoma (MS)and Rhabdomyosarcoma (RMS). Read More

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October 2018
4 Reads

Endoscopic endonasal approach to primitive Meckel's cave tumors: a clinical series.

Acta Neurochir (Wien) 2018 Dec 31;160(12):2349-2361. Epub 2018 Oct 31.

Department of Neurosurgery, DIBINEM, University of Bologna, Bologna, Italy.

Introduction: Recently, an alternative endoscopic endonasal approach to Meckel's cave (MC) tumors has been proposed. To date, few studies have evaluated the results of this route. The aim of our study was to evaluate long-term surgical and clinical outcome associated with this technique in a cohort of patients with intrinsic MC tumors. Read More

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December 2018
4 Reads

Inhibition of Osteoarthritis-Related Molecules by Isomucronulatol 7--β-d-glucoside and Ecliptasaponin A in IL-1β-Stimulated Chondrosarcoma Cell Model.

Molecules 2018 Oct 29;23(11). Epub 2018 Oct 29.

Life & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea.

Osteoarthritis (OA) is the common form of arthritis and is characterized by disability and cartilage degradation. Although natural product extracts have been reported to have anti-osteoarthritic effects, the potential bioactivity of Ryupunghwan (RPH), a traditional Korean medicinal botanical formula that contains , , , , , , and , is not known well. Therefore, the inhibitory effects of single compounds isolated from RPH on the OA-related molecules were investigated using IL-1β-stimulated chondrosarcoma SW1353 (SW1353) cell model. Read More

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October 2018
7 Reads

Mesenchymal hamartoma of the chest wall in a 10-year-old girl mimicking malignancy: a case report.

Skeletal Radiol 2018 Oct 29. Epub 2018 Oct 29.

Department of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

We herein report a rare case of mesenchymal hamartoma of the chest wall in a 10-year-old girl. She complained of chest pain and was diagnosed with a large chest wall tumor originating from the left fourth rib. Malignancy such as osteosarcoma or chondrosarcoma could not be ruled out with imaging studies. Read More

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October 2018
2 Reads

Prosthetic Rehabilitation with Palatal Lift/Augmentation in a Patient with Neurologic/Motor Deficit Due To Cancer Therapy for Chondrosarcoma.

J Prosthodont 2018 Oct 24. Epub 2018 Oct 24.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.

This clinical report describes the prosthetic rehabilitation of a 25-year-old man with a history of grade II chondrosarcoma at the skull base who had undergone surgical resection and thereafter developed velopharyngeal incompetency (VPI), dysarthria, and dysphagia. Upon baseline fiberoptic endoscopic evaluation of swallowing (FEES), the patient had an atypical pattern of VPI with minimal to no velar lift during speech, blow, or suck tasks, but near complete velar lift and seal during swallowing. A palatal augmentation prosthesis combined with a resilient palatal lift extension was fabricated to enhance speech by displacing the soft palate and to decrease hypernasality, while avoiding interference with bolus transport. Read More

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October 2018
3 Reads

The usefulness of wide excision assisted by a computer navigation system and reconstruction using a frozen bone autograft for malignant acetabular bone tumors: a report of two cases.

BMC Cancer 2018 Oct 24;18(1):1036. Epub 2018 Oct 24.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Background: Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimensional osteotomy is difficult particularly around the acetabulum. Additionally, removal of the joint makes reconstruction very difficult; thus, retention of good function also becomes difficult. In musculoskeletal oncology, computer navigation systems are still not widely used to prevent tumor-positive margins. Read More

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October 2018
1 Read

Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features.

Diagn Cytopathol 2018 Nov 24;46(11):950-957. Epub 2018 Oct 24.

Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.

Background: Extraskeletal myxoid chondrosarcoma (EMC) is a tumor of uncertain differentiation. Few data are available regarding its cytomorphological features in fine-needle aspiration (FNA). Specific cytogenetic alterations involving the NR4A3 gene are found in EMC and can be identified in FNA samples. Read More

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November 2018

Primary orbital mesenchymal chondrosarcoma.

Can J Ophthalmol 2018 Oct 3;53(5):e205-e207. Epub 2018 Feb 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

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October 2018

Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety.

Cancers (Basel) 2018 Oct 18;10(10). Epub 2018 Oct 18.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

(1) Background: The authors present the first results of active raster-scanned carbon ion radiotherapy (CIRT) for radioresistant laryngeal malignancies regarding efficacy and toxicity. (2) Methods: 15 patients with laryngeal adenoid cystic carcinoma (ACC; = 8; 53.3%) or chondrosarcoma (CS; = 7; 46. Read More

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October 2018
4 Reads

Clinical and radiographic presentation of pelvic sarcoma in children.

SICOT J 2018 19;4:44. Epub 2018 Oct 19.

Department of Orthopaedics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Introduction: Pelvic sarcomas may present with vague symptoms. The aim of this study was to examine the characteristics and clinical presentations of different types of pelvic sarcoma in children.

Methods: This is a retrospective cohort study of patients up to 21 years of age with the diagnosis of pelvic sarcoma between January 2000 and June 2013. Read More

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October 2018
2 Reads

HER-2 Immunohistochemical Expression in Bone Sarcomas: A New Hope for Osteosarcoma Patients.

Open Access Maced J Med Sci 2018 Sep 4;6(9):1555-1560. Epub 2018 Sep 4.

Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Osteosarcoma and chondrosarcoma, remain the most common primary bone tumours. Questions have been raised about the prognostic influence of HER-2 in bone sarcomas, but so far the results have been debatable. The her-2 expression is possibly a predictor of chemotherapy response. Read More

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September 2018

Scapular reconstructions after resection for bone tumors: a single-institution experience and review of the literature.

Acta Biomed 2018 Oct 8;89(3):415-422. Epub 2018 Oct 8.

Gaetano Pini-CTO, Milano.

Scapulectomy and limb-salvage surgery are indicated for low and high-grade tumors of the scapula and soft-tissue sarcomas that secondary invade the bone. After total or partial scapulectomy there are 3 options of reconstruction: humeral suspension (flail shoulder), total endoprosthesis and massive bone allograft. Nowadays prosthesis and allograft reconstructions are the most used and humeral suspension is reserved only as salvage technique when no other surgery is possible. Read More

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October 2018

Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma.

NMC Case Rep J 2018 Oct 13;5(4):99-103. Epub 2018 Sep 13.

Department of Neurosurgery, Fukushima Medical University, Fukushima, Fukushima, Japan.

We report a case of a young male who received multiple surgical treatments for repeated recurrence of skull base mesenchymal chondrosarcoma (MC). When the patient was 18 years old, we subtotally removed the skull base MC and he was treated with stereotactic radiosurgery for remnant tumors in the left cavernous sinus. After 30 months, we removed residual tumors that had regrown partially, via combined endonasal endoscopic and orbitozygomatic approaches. Read More

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October 2018
1 Read

Myxoid chondrosarcoma extraskeletal in pelvis location : a case report.

Tunis Med 2018 Jan;96(1):84-86

Background: The extraskeletal myxoid chondrosarcoma (CME) is a rare tumor of the soft tissue, with clinically distinguishable clinical, histological, immunohistochemical, cytogenetic and evolutionary characteristics with an unfavorable long-term prognosis.

Case: We reported the case of a young patient of 18 years, accusing pelvic pain for 5 months with a poor general condition, an MRI was performed immediately, objective infiltrative mass endopelvic evoking several etiologies. The histology of the biopsy extraskeletal myxoid chondrosarcoma reveals a (CME). Read More

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January 2018

Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):577-579

Department of Histopathology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.

Pure mesenchymal sarcomas and phyllodes tumor with sarcomatous differentiation of the breast are rare tumors. Primary breast sarcomas are a heterogenous group of neoplasms which include malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Sarcomatous differentiation in phyllodes tumor is seen in the form of angiosarcoma, chondrosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Read More

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October 2018
2 Reads

IDH mutation status in a series of 88 head and neck chondrosarcomas: different profile between tumors of the Skull Base and tumors involving the facial skeleton and the Layngotracheal tract.

Hum Pathol 2018 Oct 5. Epub 2018 Oct 5.

CHRU de Tours, Service d'Anatomie et Cytologie Pathologiques, Tours, France; Université François Rabelais, Faculté de Médecine, Tours, France; Laboratoire d'étude des sarcomes osseux et remodelage des tissus calcifiés, PhyOS - INSERM UMR 1238, Faculté de Médecine de Nantes, Université de Nantes, 44034 Nantes, cedex 1, France. Electronic address:

Chondrosarcomas are rare primary malignant bone tumors that involve the head and neck region in 1% to 12% of cases. Central conventional chondrosarcoma is the most common subtype and is associated with isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene mutations in 50% to 60% of cases. We aimed to define the frequency of IDH1 and IDH2 gene mutations in a multicenter series of 88 cases of chondrosarcoma of the head and neck, including tumors involving the base of the skull (n=30), the facial skeleton (n=11), and the laryngeal and tracheal cartilages (n=47). Read More

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October 2018
3 Reads

Chondrosarcoma: An overview of clinical behavior, molecular mechanisms mediated drug resistance and potential therapeutic targets.

Crit Rev Oncol Hematol 2018 Nov 12;131:102-109. Epub 2018 Sep 12.

Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. Electronic address:

Sarcomas are known as a heterogeneous class of cancers arisen in the connective tissues and demonstrated various histological subtypes including both soft tissue and bone origin. Chondrosarcoma is one of the main types of bone sarcoma that shows a considerable deficiency in response to chemotherapy and radiotherapy. While conventional treatment based on surgery, chemo-and radiotherapy are used in this tumor, high rate of death especially among children and adolescents are reported. Read More

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November 2018
2 Reads

Primary tumors of the hand: Functional and restorative management.

J Surg Oncol 2018 Nov 7;118(6):873-882. Epub 2018 Oct 7.

Division of Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California.

Primary malignant tumors of the hand are rare. Most cases present to clinics unaffiliated with cancer centers, making it incumbent on all hand surgeons to understand the pathology indicative of malignancy and the proper course of treatment of hand neoplasms. In this review, we report, based on tumor type, the anatomical considerations, proper management, staging, surgical approaches, reconstructive considerations, and long-term surveillance of primary malignant tumors of the hand. Read More

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November 2018
5 Reads

H3K27me3 deficiency defines a subset of dedifferentiated chondrosarcomas with characteristic clinicopathological features.

Mod Pathol 2018 Oct 5. Epub 2018 Oct 5.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

Dedifferentiated chondrosarcoma is a rare bone sarcoma, whose genetic background remains incompletely understood. Mutations in SUZ12 or EED, which encode polycomb repressive complex 2 (PRC2) components, and resulting deficiency in H3K27me3 are characteristic features of the majority of malignant peripheral nerve sheath tumors. Here, we investigated H3K27me3 and PRC2 status in dedifferentiated chondrosarcoma. Read More

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October 2018

The impact of biopsy sampling errors and the quality of surgical margins on local recurrence and survival in chondrosarcoma.

Cancer Manag Res 2018 21;10:3765-3771. Epub 2018 Sep 21.

Orthopaedic Department, Balgrist University Hospital, Zürich, Switzerland,

Purpose: To examine the frequency of computed tomography (CT)-guided biopsy sampling errors in chondrosarcomas, as well as the impact of these errors and the achieved surgical margins on local recurrence-free survival (LRFS) and disease-specific survival (DSS).

Material And Methods: A total of 68 consecutive patients treated for chondrosarcoma from 2000-2015 were retrospectively reviewed with a minimum follow-up duration of 2 years.

Results: The primary location was at the extremities in 46 patients (67. Read More

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September 2018
1 Read

Sarcomatoid urothelial bladder carcinoma in adults: Histology, symptomatology, treatments and survival.

Actas Urol Esp 2018 Oct 1. Epub 2018 Oct 1.

Servicio Urologia, Hospital Universitari Son Espases, Palma de Mallorca, España.

Objective: Sarcomatoid urothelial bladder carcinoma comprises 3% of the tumours of the bladder and is considered one of the most aggressive tumours of the urinary tract. Our aim is to analyse the characteristics of sarcomatoid urothelial bladder carcinoma in adults, its treatments and survival.

Method: A retrospective study performed between 2000 and 2017 of all the patients with a sarcomatoid urothelial bladder carcinoma in a single centre. Read More

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October 2018

Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone.

J Pathol 2018 Oct 3. Epub 2018 Oct 3.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, U.K.

Undifferentiated pleomorphic sarcoma of bone (UPSb), is a rare primary bone sarcoma that lacks a specific line of differentiation. There is very little information about the genetic alterations leading to tumourigenesis or malignant transformation. Distinguishing between UPSb and other malignant bone sarcomas, including dedifferentiated chondrosarcoma and osteosarcoma, can be challenging due to overlapping features. Read More

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October 2018
7 Reads

Enchondroma Protuberans of the Transverse Process of D8 Vertebra Extending to the 7th and 8th Ribs: A Rare Case Report.

Int J Spine Surg 2018 Jan 30;12(1):43-48. Epub 2018 Mar 30.

Spine Department, Star Hospitals, Road No. 10, Banjara Hills, Hyderabad, Telangana, India.

Background: Enchondroma protuberans (EP) is rare, benign cartilaginous bone tumor arising from the intramedullary cavity of long bones and usually protrudes beyond the cortex with an exophytic growth pattern resembling osteochondroma. This study reports on a rare case of EP arising from the transverse process of the D8 vertebra and extending to the adjacent 7th and 8th ribs and the paraspinal tissues.

Methods: A 45-year-old female patient came in with complaints of upper back pain radiating up to the left costal margin for the past 6 months. Read More

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January 2018
7 Reads

The In Vitro Effects of Bupivacaine on Cartilage-forming Tumor Cells.

J Am Acad Orthop Surg 2018 Oct 1. Epub 2018 Oct 1.

From the Department of Orthopaedic Surgery (Dr. Chapman and Dr. Zuckerman), Loma Linda University Health, and the Department of Medicine & Basic Science (Dr. Mirshahidi), Loma Linda University Cancer Center, Biospecimen Laboratory, Loma Linda, CA.

Introduction: Bupivacaine is a commonly used local anesthetic that has been shown to be cytotoxic to articular chondrocytes and various tumor cells. This study evaluates the in vitro effects of bupivacaine on cartilaginous tumor cells.

Methods: Multiple different cartilaginous tumors were evaluated, including enchondromas, chondroblastomas, a low-grade chondrosarcoma, which were harvested from patients during tumor resection, and a grade-II chondrosarcoma SW1535 (ATCC HTB-94). Read More

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October 2018

Self Limiting Sternal Tumors of Childhood: Two Case Reports.

Authors:
D Adri T Kreindel

Radiologia 2018 Sep 28. Epub 2018 Sep 28.

Servicio de Diagnóstico por Imágenes, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Sternal tumours are rare in children. The differential diagnoses include a wide spectrum of benign (from bone cyst to osteoblastoma, osteochondroma and fibrous displasia) and malignant tumours (Ewing's sarcoma, chondrosarcoma rhabdomyosarcoma), inflammatory lesions and infectious processes. The SELSTOC (Self Limiting Sternal Tumours of Childhood) are entities of non-specific origin, they are self-limiting and characterised by a rapidly growing tumour that disappears spontaneously with no history of trauma or active infection. Read More

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September 2018
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Huge sternal chondrosarcoma: a case report.

Asian Cardiovasc Thorac Ann 2018 Oct 30;26(8):632-634. Epub 2018 Sep 30.

Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

A 75-year-old man presented very late with a huge sternal mass that measured 91 × 84 mm on computed tomography. A core needle biopsy revealed atypical cartilage tissue, suggesting chondrosarcoma. The mass was resected and the defect was reconstructed with bone cement, Prolene mesh, and a muscle flap. Read More

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October 2018

Radiofrequency ablation in the treatment of atypical cartilaginous tumours in the long bones: lessons learned from our experience.

Skeletal Radiol 2018 Sep 29. Epub 2018 Sep 29.

Department of Orthopaedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Surgery is the cornerstone of treatment of symptomatic cartilaginous neoplasms. We previously studied the application of radiofrequency ablation of atypical cartilaginous tumours in the long bones. The purpose of the present study was to investigate the additional effect of placing multiple needles and a longer procedure duration on the proportion of completely ablated tumours. Read More

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September 2018
4 Reads

Novel Chest Wall Reconstruction Following Excision of an Xiphisternal Chondrosarcoma.

Ochsner J 2018 ;18(2):180-182

The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.

Background: Chondrosarcoma, the most common primary malignant tumor of the chest wall, most frequently arises from the sternum, with limited reported cases of tumor origination from the xiphoid process. Because of the location, patients present with complaints of a large chest wall mass associated with pain and respiratory symptoms. These tumors are best managed by en bloc resection and chest wall reconstruction. Read More

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January 2018