Search Our Scientific Publications & Authors

J Med Imaging Radiat Oncol 2021 Jun 20. Epub 2021 Jun 20.

Benson Radiology, Adelaide, South Australia, Australia.

A 36-year-old female patient was diagnosed with a parosteal lipoma arising from the left 3rd rib. This was preluded by a 5-year history of an asymptomatic and stable mass at the medial aspect of the left scapula. It had displayed an interval enlargement in the preceding 3 months which prompted investigation to rule out an aggressive lesion. Read More

J Orthop Case Rep 2021 ;11(1):79-81

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Chondromyxoid fibroma (CMF) is an uncommon benign tumor accounts for <2% of all benign and <1% all bone tumors. It is a cartilage tumor with myxoid and fibrous elements. Because of rarity and resemblance with other benign and malignant tumor, diagnosis of this tumor always remains challenging. Read More

Nucl Med Mol Imaging 2021 Jun 16;55(3):141-145. Epub 2021 Mar 16.

Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 India.

Chondrosarcoma is a cartilaginous tumor of mesenchymal origin. The histology and grade of the tumor determine the chances of relapse and survival. These tumors usually respond poorly to chemo-radiotherapy in cases of non-resectable and recurrent disease. Read More

Cureus 2021 Apr 17;13(4):e14531. Epub 2021 Apr 17.

Internal Medicine, Detroit Medical Center (DMC), Detroit, USA.

Osteochondroma is the most common benign tumor of bone that often produces no symptoms unless the enlarged mass affects nearby structures. Rarely, Horner syndrome can be caused by an osteochondroma. A five-year-old female with a past medical history of seizure-like activity presented to the emergency department on three separate occasions within one month. Read More

Cancers (Basel) 2021 May 14;13(10). Epub 2021 May 14.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.

Chondrosarcoma (CHS) is the second most common primary malignant bone sarcoma. Overall survival and prognosis of this tumor are various and often extreme, depending on histological grade and tumor subtype. CHS treatment is difficult, and surgery remains still the gold standard due to the resistance of this tumor to other therapeutic options. Read More

EBioMedicine 2021 May 25;68:103407. Epub 2021 May 25.

Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy; IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Background: Clinical management ranges from surveillance or curettage to wide resection for atypical to higher-grade cartilaginous tumours, respectively. Our aim was to investigate the performance of computed tomography (CT) radiomics-based machine learning for classification of atypical cartilaginous tumours and higher-grade chondrosarcomas of long bones.

Methods: One-hundred-twenty patients with histology-proven lesions were retrospectively included. Read More

J Orthop Surg Res 2021 May 28;16(1):343. Epub 2021 May 28.

Department of Orthopedics, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, Hunan, 410013, People's Republic of China.

Background: Surgical resection and reconstruction for low-grade bone sarcoma in the metaphysis of the distal femur remain challenging. We hypothesized that 3D printing osteotomy guide plate could assist to accurately resect the tumor lesion and save the joint function.

Methods: From January 2017 to August 2019, five patients diagnosed with low-grade bone sarcoma in the metaphysis of the distal femur were treated with hemicortical resection using 3D printing guide plate. Read More

Clin Med Res 2021 May 13. Epub 2021 May 13.

Department of Laboratory medicine and Hemato-pathology, Mayo Clinic Health System, Eau Claire, WI 54702.

Paraneoplastic arthritides are a group of immune mediated inflammatory arthropathies associated with occult or manifest malignancy. Musculoskeletal spread of an underlying malignancy may also mimic many rheumatologic conditions. Distinguishing primary rheumatologic condition from paraneoplastic arthritides versus direct musculoskeletal spread of malignancy can be challenging especially in individuals with prior history of cancer and new musculoskeletal complaints. Read More

J Magn Reson Imaging 2021 May 6. Epub 2021 May 6.

Department of Radiology, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

J Magn Reson Imaging 2021 May 5. Epub 2021 May 5.

Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China.

Background: Differentiating chondrosarcoma from enchondroma using conventional MRI remains challenging. An effective method for accurate preoperative diagnosis could affect the management and prognosis of patients.

Purpose: To validate and evaluate radiomics nomograms based on non-enhanced MRI and clinical risk factors for the differentiation of chondrosarcoma from enchondroma. Read More

Surg Neurol Int 2021 8;12:137. Epub 2021 Apr 8.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, United States.

Background: Intracranial chondrosarcomas are slowly growing malignant cartilaginous tumors that are especially rare in adolescents.

Case Description: A 19-year-old woman with no medical history presented with symptoms of intermittent facial twitching and progressive generalized weakness for 6 months. The patient's physical examination was unremarkable. Read More

Oper Neurosurg (Hagerstown) 2021 05;20(6):E422-E423

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Complete resection of skull base chondrosarcomas offers the potential for a durable, or even lifelong, cure and is best achieved at the first surgery.1,2 When a skull base chondrosarcoma is located at the upper clivus and in the interpeduncular cistern and invading laterally toward the petrous apex and cavernous sinus, the traditional approaches, ie, endonasal endoscopic or middle fossa approaches, are not adequate for the exposure and resection. The transcavernous sinus approach has been utilized to remove tumor from the cavernous sinus and as a corridor to the interpeduncular cistern and upper clivus, originally described for the clipping of basilar apex aneurysms. Read More

World J Clin Cases 2021 Apr;9(10):2302-2311

Department of Orthopedic Surgery, China Medical University Hospital, China Medical University, Taichung City 40454, Taiwan.

Background: Chondrosarcoma, a cartilage matrix producing tumor, is the second most commonly observed primary bone tumor after osteosarcoma, accounting for 15% of all chest wall malignancies. We herein report the case of a patient with chondrosarcoma of the sternum and our management of the chest wall defects that presented following radical tumor resection.

Case Summary: A 31-year-old patient presented to our hospital with dull pain and a protruding mass overlying the chest for 3 mo. Read More

Clin Radiol 2021 Apr 14. Epub 2021 Apr 14.

Radio-diagnosis Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Aim: To evaluate the ability of diffusion-weighted magnetic resonance imaging (DW-MRI) to differentiate between benign and malignant bony tumours.

Materials And Methods: This prospective study was conducted from October, 2018 to December, 2019. The study included 62 patients (37 male and 25 female) with clinically suspected bony lesions referred to the Radiology Department. Read More

Int J Surg Pathol 2021 Apr 13:10668969211010221. Epub 2021 Apr 13.

9310Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Dedifferentiated chondrosarcoma is a well-recognized entity, but its occurrence in the distal extremities is exceedingly rare. We present the case of a 49-year-old woman who experienced local recurrence of an "enchondroma" of the proximal phalanx of the fourth finger of the left hand, which had been initially treated with intralesional curettage at another hospital 4 years before, and 1 year before for a local recurrence. The imaging findings indicated an aggressive behavior, and an incisional biopsy showed a highly cellular proliferation of spindle and pleomorphic elements without evidence of matrix production intermixed with few fragments of a well-differentiated cartilaginous neoplasm with bland cellular atypia, focal nuclear hyperchromatism, and binucleation. Read More

BMC Musculoskelet Disord 2021 Apr 12;22(1):348. Epub 2021 Apr 12.

Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Background: En bloc resection of malignant tumors involving upper thoracic spine is technically difficult. We surgically treated a patient with grade 2 chondrosarcoma involving T1-5, left upper thoracic cavity, and chest wall.

Case Presentation: A 37 years old, male patient was referred to our hospital for a huge lump involved left shoulder and chest wall. Read More

Semin Ultrasound CT MR 2021 Apr 29;42(2):123-133. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

Recent scholarship on enchondroma, chondrosarcoma, and chondroblastoma is presented. The focus of this article is on the imaging appearance of these tumors and the means by which they can be distinguished from one another by both clinical and imaging criteria. Read More

Skeletal Radiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.

Solitary osteochondromas are common, benign hyaline cartilage-capped exostoses that primarily arise from the metaphyses of long and flat bones. Diaphyseal aclasis is an autosomal dominant condition resulting from EXT1 or EXT2 gene mutations and is characterized by multifocal osteochondromas. These can result in a wide spectrum of complications, such as skeletal deformity, neurological and vascular complications, adventitial bursa formation, fracture, and rarely malignant transformation to peripheral chondrosarcoma. Read More

J Oral Maxillofac Surg 2021 Feb 27. Epub 2021 Feb 27.

Associate Professor, Division of Oral and Maxillofacial Pathology, Columbia University Irving Medical Center, New York City, NY.

Mesenchymal chondrosarcoma is a rare high-grade variant of chondrosarcoma distinguished by its aggressive nature. Molecular studies aid in establishing the diagnosis. We present a case report of mesenchymal chondrosarcoma in the maxilla of a 39-year-old male patient and a literature review of 42 gnathic cases of mesenchymal chondrosarcoma with a discussion of clinical, imaging, microscopic, immunohistochemical, and molecular features. Read More

Magn Reson Med 2021 08 27;86(2):1008-1018. Epub 2021 Mar 27.

INRAE, UR QuaPA, Saint-Genès-Champanelle, France.

Purpose: To evaluate the relevance of CEST frequency selectivity in simultaneous in vivo imaging of both of chondrosarcoma's phenotypic features, that are, its high proteoglycan concentration and its hypoxic core.

Methods: Swarm rat chondrosarcomas were implanted subcutaneously in NMRI nude mice. When tumors were measurable (12-16 days postoperative), mice were submitted to GAG, guanidyl, and APT CEST imaging. Read More

J Clin Orthop Trauma 2021 Jun 27;17:106-111. Epub 2021 Feb 27.

Orthopaedic Oncology, Royal Orthopaedic Hospital, Birmingham, B21 3AP, United Kingdom.

Aim: To ascertain the changing incidence over time of the three commonest primary sarcomas of bone. Data obtained with particular reference to central chondrosarcoma from the annual referral rate to a large UK-based specialist orthopaedic oncology unit. To discuss how the "barnyard pen" analogy of cancers previously applied to certain commoner cancers can also be applicable to central chondrosarcoma (CS) of bone. Read More

Clin Podiatr Med Surg 2021 Apr 26;38(2):227-233. Epub 2021 Jan 26.

The Iowa Clinic, 5950 University Avenue West, Des Moines, IA 50266, USA; Unitypoint Health - Iowa Methodist Medical Center, 1415 Woodland Avenue, Des Moines, IA 50309, USA.

Bone tumors of the foot are an uncommon finding. Most tumors are found incidentally on imaging and are benign. Care must be taken although due to the aggressive nature of malignant bone tumors that can occur in the calcaneus. Read More

J Craniofac Surg 2021 Mar 17. Epub 2021 Mar 17.

Department of Plastic and Reconstructive Surgery, Saitama Medical Center, Jichi Medical University Department of Plastic and Reconstructive Surgery, Jichi Medical University Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Tochigi 329-0498, Japan.

Abstract: The authors report a case of a rare, large, nodular pseudogout which developed from the temporomandibular joint (TMJ).An 83-year-old female was referred to the hospital with swelling on her left cheek. Imaging studies revealed a large calcified mass surrounding the left mandibular condyle, partially destroying the adjoining bone and extending to the skull base. Read More

Ann Med Surg (Lond) 2021 Mar 23;63:102187. Epub 2021 Feb 23.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco.

Introduction: The hemostatic agents have increased the bleeding complication in many surgeries. The SURGICEL is a preparation of oxidized cellulose regenerated from alpha-cellulose in an organic solvent, this product has the characteristic of resorbing without having a reaction of foreign body in 4-8 weeks.

Case Presentation: We report the case of a patient operated on for a chondrosarcoma of the right temporomandibular joint with normal postoperative consequences, nevertheless after 3 months, the patient consulted again for the same symptomatology. Read More

Radiol Case Rep 2021 May 26;16(5):1099-1102. Epub 2021 Feb 26.

Department of Radiotherapy, Faculty of Medicine, Mohammed VI University of Health Sciences/Cheikh Khalifa International University Hospital, 82403, Oum Rabii, Hay Hassani, Casablanca, Morocco.

Chondrosarcoma of the head and neck region is a rare disease, representing approximately 0.1% of all head and neck neoplasms. Parapharyngeal location is extremely rare and low-grade ones are even rarer. Read More

J Surg Oncol 2021 May 13;123(8):1821-1827. Epub 2021 Mar 13.

Department of Orthopedics, Radboud University Medical Center, Nijmegen, The Netherlands.

Background And Objectives: Intralesional surgical treatment is the preferred therapy for atypical cartilaginous tumors (ACTs) of the long bones in many institutions. However, the literature is still controversial regarding intralesional treatment versus wide resection. Due to the relative rarity of these tumors, studies reporting on the results of intralesional treatment are often small sample studies. Read More

Surg Oncol 2021 Jun 5;37:101537. Epub 2021 Mar 5.

Department of Radiology, Ege University Faculty of Medicine, Turkey.

Background: A fundamental aspect of oncosurgical planning in organ resections is the identification of feeder vessel details to preserve healthy organ tissue while fully resecting the tumors. The purpose of this study was to determine whether three-dimensional (3D) cancer case models of computed tomography (CT) images will assist resident-level trainees in making appropriate operative plans for organ resection surgery.

Methods: This study was based on the perception of surgery residents who were presented with 5 different oncosurgical scenarios. Read More

J Orthop Case Rep 2020 Nov;10(8):44-47

Department of Orthopaedics, Era's Lucknow Medical College, Lucknow. Uttar Pradesh. India.

Introduction: Synovial chondromatosis (SC) commonly involves large joints such as the knee and hip with smaller joints being less frequently involved. Extra-articular involvement is very rare, and here, we are presenting the first case of giant extra-articular SC originating from the ankle joint.

Case Report: A 42-year-old male presented to the outpatient department with painless swelling over the lateral malleolus for 2 years. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24817

Department of Orthopedic Surgery, Anam Hospital, Korea University College of Medicine.

Rationale: Localized chondrosarcoma of the scapula has a favorable long-term survival outcome. Therefore, recovery of shoulder function after surgery is important in middle-aged patients. Currently, three-dimensional (3-D) printing implants can be applied for personalized limb salvage surgery. Read More

Acta Radiol 2021 Feb 27:284185121996268. Epub 2021 Feb 27.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, 65526Asan Medical Center, Seoul, Republic of Korea.

Background: Diagnostic performance, inter-observer agreement, and intermodality agreement between computed tomography (CT) and magnetic resonance imaging (MRI) in the depiction of the major distinguishing imaging features of central cartilaginous tumors have not been investigated.

Purpose: To determine the inter-observer and intermodality agreement of CT and MRI in the evaluation of central cartilaginous tumors of the appendicular bones, and to compare their diagnostic performance.

Material And Methods: Two independent radiologists retrospectively reviewed preoperative CT and MRI. Read More