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J Surg Case Rep 2022 Jun 22;2022(6):rjac286. Epub 2022 Jun 22.

Otorhinolaryngology and Head and Neck Surgery Department, Mohammed VI University Hospital of Oujda, Oujda, Morocco.

Chondrosarcoma is a highly aggressive malignant tumor originating from cartilaginous and mesenchymal tissues. The aim of this report is to describe a rare case of nasosinusal chondrosarcoma with orbito-cerebral extension. Our patient was a 55-year-old with a right cheek swelling evolving over a year, with unilateral right nasal obstruction gradually becoming bilateral associated with hyposmia, bilateral exophthalmos, reduced bilateral deep visual acuity and permanent headaches. Read More

Mol Clin Oncol 2022 Jul 19;17(1):114. Epub 2022 May 19.

The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Carbon ion therapy (CIT) is a form of particle therapy, which not only spares normal tissues but may also improve local control of recurrent intracranial tumours. Cerebral radiation necrosis (RN) is one of the most serious adverse reactions of recurrent brain tumours following reirradiation, which may lead to neurological decline or even death. Bevacizumab is an anti-vascular endothelial growth factor antibody, which has been used to treat symptomatic RN. Read More

Molecules 2022 Jun 11;27(12). Epub 2022 Jun 11.

Université Clermont Auvergne, Inserm, Imagerie Moléculaire et Stratégies Théranostiques, UMR 1240, F-63000 Clermont-Ferrand, France.

Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic cholangiocarcinoma). These mutated variants of IDH (mIDH) acquire a neomorphic activity, namely, conversion of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate involved in tumourigenesis. Thus, mIDHs have emerged as highly promising therapeutic targets, and several mIDH specific inhibitors have been developed. Read More

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

San Salvatore Hospital, 67100 L'Aquila, Italy.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc. Read More

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e60-e61. Epub 2022 Apr 20.

Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Indian J Radiol Imaging 2022 Mar 19;32(1):71-80. Epub 2022 Apr 19.

Department of Neurosurgery, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.

There are many types of neoplasms in or around the foramen of Luschka (FL), and definitive diagnosis in some cases requires knowledge of imaging findings. The uncommon and challenging neoplasms with FL involvement considered in this study are exophytic brainstem glioma, primary glioblastoma of the cerebellopontine angle (CPA), primary anaplastic ependymoma of the CPA, choroid plexus papilloma of the FL, solitary FL choroid plexus metastasis, extraskeletal myxoid chondrosarcoma of the jugular foramen, paraganglioma of the jugular foramen, exostosis of the jugular foramen, psammomatous meningioma in the lateral cerebellar medullary cistern, epidermoid tumor of the fourth ventricle, and a hypoglossal schwannoma. These neoplasms may have overlapping clinical and imaging features, but some have relatively distinct imaging features. Read More

Cureus 2022 May 7;14(5):e24800. Epub 2022 May 7.

Pulmonary Critical Care, Staten Island University Hospital, Staten Island, USA.

Chondroma is a rare benign tumor of the cartilage and occurs in the tracheobronchial tree, either isolated or as part of the Carney triad. It has been sparsely described in the literature, and some were mislabeled as hamartomas. We herein report a case of a 63-year-old female who was initially treated for community-acquired right middle lobe pneumonia. Read More

World J Clin Cases 2022 May;10(13):4301-4313

Department of Neurosurgery, The First Hospital Affiliated to Jilin University, Changchun 130021, Jilin Province, China.

Background: Primary intracranial extraskeletal myxoid chondrosarcoma (EMC) is an extremely rare low- to intermediate-grade malignant soft tissue sarcoma, and only 15 cases have been reported in the literature. Due to its rarity, clinical data and research on this tumor type are extremely limited, the pathogenesis and histological origin are still unclear, and the diagnostic and standard clinical treatment strategies for intracranial EMC remain controversial and undefined.

Case Summary: We reported a case of a 52-year-old male who was admitted to the hospital with headache and dizziness for 1 mo, and his health status deteriorated during the last week. Read More

Zhonghua Wai Ke Za Zhi 2022 Jun;60(6):567-572

Department of Bone and Soft Tissue,Zhenghzhou University Affiliated Cancer Hospital,Henan Cancer Hospital,Key Laboratory for Digital Assessment of Spinal-pelvic Tumor and Surgical Aid Tools Design (Zhengzhou),Key Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan),Zhengzhou 450003, China.

To explore the possible clinical benefits of CT/MRI image fusion and computer-assisted simulation techniques in guiding type â…¢ and â…£ primary pelvic bone tumor surgeries. The clinic data of primary bone sarcomas patients treated at Department of Bone and Soft Tissue,Zhenghzhou University Affiliated Cancer Hospital from January 2019 to December 2021 were retrospectively analyzed. Based on whether the CT and MRI image fusion technique was utilized for tumor evaluation and surgical planning,the patients were divided into image fusion group (=21) or control group (=27). Read More

Interact Cardiovasc Thorac Surg 2022 Jun;35(1)

Thoracic Surgery Unit, University Hospital Careggi, Florence, Italy.

Carinal re-resection for tumour recurrence is rarely performed due to increased difficulty in airway reconstruction. We reported a successful case of carinal resection and reconstruction for recurrent chondrosarcoma after previous distal tracheal resection. Due to the technical complexity of the reconstruction and the poor respiratory reserve of the patient, the veno-venous extracorporeal membrane oxygenation support was used. Read More

Acta Neurochir (Wien) 2022 Jul 25;164(7):1939-1948. Epub 2022 May 25.

School of Biomedical Engineering and Imaging Sciences, St Thomas' Hospital, King's College, London, SE1 7EH, UK.

Background: The vidian canal (VC) is normally a reliable anatomical landmark for locating the petrous internal carotid artery (pICA). This study determined the influence of petroclival chondrosarcoma on the relationship between the VC and pICA.

Methods: Nine patients (3 males, 6 females; median age 49) with petroclival chondrosarcoma, and depiction of the pICA on contrast-enhanced CT, were retrospectively studied. Read More

J Belg Soc Radiol 2022 5;106(1):40. Epub 2022 May 5.

AZ Sint-Maarten and Catholic University of Leuven, BE.

A chondroid lipoma is a rare benign adipocytic neoplasm, containing a chondromyxoid matrix, that may mimic a myxoid liposarcoma and myxoid chondrosarcoma. Read More

Int J Surg Case Rep 2022 Jun 11;95:107189. Epub 2022 May 11.

Department of Orthopaedic Surgery, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan. Electronic address:

Introduction And Importance: Scapular prostheses are useful in shoulder stability after shoulder girdle resection for malignant bone tumors; however, they are difficult to obtain in Japan. Therefore, other methods must be considered, depending on the extent of resection. We report a case in which a clavicle-locking plate, Nesplon tape, and a proximal humeral prosthesis were used to ensure shoulder stability and preserve stable upper limb function. Read More

Cancer Rep (Hoboken) 2022 May 10:e1621. Epub 2022 May 10.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background: Primary laryngeal chondrosarcomas are rare entities whose excellent survival rates following resection promote conservative surgical approaches to maintain quality of life without compromising outcomes. There are excellent outcomes in skull base chondrosarcomas treated with maximal safe resection and post-operative proton therapy. Extrapolating from these findings, we report our institutional experience treating symptomatic or growing laryngeal chondrosarcomas using proton beam therapy. Read More

J Bone Oncol 2022 Jun 16;34:100430. Epub 2022 Apr 16.

Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan.

Background: Chondrosarcoma is a common form of malignant bone tumor with limited treatment options. Approximately half of chondrosarcomas harbor gain-of-function mutations in isocitrate dehydrogenase (IDH), and mutant IDH produces 2-hydroxyglutarate (2-HG), which is an oncometabolite that contributes to malignant transformation. Therefore, inhibiting 2-HG production is a novel and promising treatment for advanced chondrosarcoma. Read More

J Med Case Rep 2022 Apr 28;16(1):176. Epub 2022 Apr 28.

Department of Pathology and Biopathology Unit, Clinical Research Center, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco.

Background: Mandible can be the site of benign or malignant lesions of different origins, including odontogenic and non-odontogenic lesions. Cartilage-forming tumors have been rarely reported at this site. Chondrosarcoma is a rare malignant cartilage-producing neoplasm that is extremely rare in the mandible. Read More

Sci Rep 2022 04 28;12(1):6965. Epub 2022 Apr 28.

Department of Pathology, CUHK Medical Centre, 9 Chak Cheung Street, Shatin, New Territories, HKSAR, Hong Kong.

Deep myxoid soft tissue lesions have posed a diagnostic challenge for pathologists due to significant histological overlap and regional heterogeneity, especially when dealing with small biopsies which have profoundly low accuracy. However, accurate diagnosis is important owing to difference in biological behaviors and response to adjuvant therapy, that will guide the extent of surgery and the need for neo-adjuvant therapy. Herein, we trained two convolutional neural network models based on a total of 149,130 images representing diagnoses of extra skeletal myxoid chondrosarcoma, intramuscular myxoma, low-grade fibromyxoid sarcoma, myxofibrosarcoma and myxoid liposarcoma. Read More

Int J Surg Case Rep 2022 May 29;94:106985. Epub 2022 Mar 29.

Hamad Medical Corporation, Doha, Qatar.

Introduction: Lumbar Spine Chondrosarcomas are rare entities that accounts for less than 10% of all spinal Chondrosarcomas, patients can present with symptoms of nerve root irritation secondary to direct compression caused by the tumor mass effect. Radiologically these tumors are destructive in nature with soft tissues classifications, and the treatment of choice for it is complete surgical excision, however in some scenarios they are difficult to access and complete resection becomes not feasible.

Presentation Of Case: A 37 years old male, presented to our spine clinic with chief complaint of chronic low back pain with radicular symptoms, normal power in both lower limbs, while his radiological evaluation showed intra-spinal extra-dural Chondrosarcoma arising from the posterior cortex of the 5th vertebral body, for which he underwent surgical decompression of the lumbar canal with resection of the lesion and unilateral stabilization of the spinal segment. Read More

BMC Neurol 2022 Apr 11;22(1):134. Epub 2022 Apr 11.

Universiti Malaysia Sarawak (UNIMAS), Kota Samarahan, Sarawak, Malaysia.

Background: We report a rare case of Godtfredsen syndrome caused by clival chondrosarcoma and perform a review of literatures. This article also explains the clinico-anatomical correlation of this rare neurological syndrome.

Case Presentation: A 22-year-old gentleman presented with binocular diplopia. Read More

World Neurosurg 2022 Jul 30;163:e230-e237. Epub 2022 Mar 30.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Objective: Internal carotid artery (ICA) injury during transsphenoidal surgery is a rare but serious complication. We analyzed a series of ICA injuries that occurred during a transsphenoidal approach to suggest an optimal management strategy.

Methods: Between January 2015 and May 2020, we enrolled 10 cases of ICA injury at our institution. Read More

World Neurosurg 2022 Jun 24;162:e635-e639. Epub 2022 Mar 24.

Department of Neurosurgery, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA. Electronic address:

Background: Chondrosarcoma and chordoma are often grouped together because of their similar anatomic locations, clinical presentations, histopathological and radiological findings, and growth patterns. In the present study, we investigated the clinical and prognostic differences of chondrosarcomas and chordomas of the skull base and spine.

Methods: We accessed the Surveillance, Epidemiology, and End Results database to search for patients from 2000 to 2018 with chondrosarcomas and chordomas of the skull base and spine for inclusion in the present study. Read More

Biomedicines 2022 Mar 17;10(3). Epub 2022 Mar 17.

Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany.

(1) Background: Chondrosarcoma (CS) is a malignant primary bone tumor with a cartilaginous origin. Its slow cell division and severely restricted vascularization are responsible for its poor responsiveness to chemotherapy and radiotherapy. The decisive factor for the prognosis of CS patients is the only adequate therapy-surgical resection. Read More

BMC Neurol 2022 Mar 23;22(1):112. Epub 2022 Mar 23.

Department of Radiology, The Second Affiliated Hospital of Fujian Medical University, 34 N, Zhong-Shan-Bei Street, Quanzhou City, Fujian Province, China.

Background: Mesenchymal chondrosarcoma (MCS) is an ultra-rare, high-grade subtype of chondrosarcoma affecting both bone and soft tissues. Extra-skeletal MCS rarely occurs in intra- and extradural regions.

Case Presentation: We presented a case of intraspinal dumbbell-shaped MCS at the T12-L2 level with isolated punctate calcification in a 19-year-old male complaining of progressive lower back pain. Read More

Eur Radiol 2022 Jul 8;32(7):4738-4748. Epub 2022 Mar 8.

Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Objectives: To evaluate the performance and reproducibility of MR imaging features in the diagnosis of joint invasion (JI) by malignant bone tumors.

Methods: MR images of patients with and without JI (n = 24 each), who underwent surgical resection at our institution, were read by three radiologists. Direct (intrasynovial tumor tissue (ITT), intraarticular destruction of cartilage/bone, invasion of capsular/ligamentous insertions) and indirect (tumor size, signal alterations of epiphyseal/transarticular bone (bone marrow replacement/edema-like), synovial contrast enhancement, joint effusion) signs of JI were assessed. Read More

Cancers (Basel) 2022 Feb 15;14(4). Epub 2022 Feb 15.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Given the difficulty and importance of achieving maximal resection in chordomas and chondrosarcomas, all available tools offered by modern neurosurgery are to be deployed for planning and resection of these complex lesions. As demonstrated by the review of our series of skull base chordoma and chondrosarcoma resections in the Advanced Multimodality Image-Guided Operating (AMIGO) suite, as well as by the recently published literature, we describe the use of advanced multimodality intraoperative imaging and neuronavigation as pivotal to successful radical resection of these skull base lesions while preventing and managing eventual complications. Read More

Diagnostics (Basel) 2022 Jan 24;12(2). Epub 2022 Jan 24.

The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21205, USA.

The purpose of our retrospective article is to review the CT imaging features of chondrosarcomas of the chest wall with pathologic correlation. For 26 subjects with biopsy-proven chondrosarcomas of the chest wall, two musculoskeletal radiologists retrospectively reviewed 26 CT scans in consensus. Descriptive statistics were performed. Read More

Internist (Berl) 2022 May 23;63(5):545-550. Epub 2022 Feb 23.

Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Here, we report on a patient with deep vein thrombosis of the right leg, in whom diagnostic work-up revealed a previously unknown chondrosarcoma of the tibia. Physical examination revealed a firm, nondisplaceable mass on the dorsal side of the right knee that appeared as a cystic formation on ultrasound. X‑ray, computed tomography, and magnetic resonance imaging were consistent with chondrosarcoma, which had likely provoked the thrombosis by local compression or paraneoplastic mechanisms. Read More

Int J Ophthalmol 2022 18;15(2):306-311. Epub 2022 Feb 18.

Department of Ocular Plastic & Orbital Disease, Tianjin Eye Hospital, Tianjin 300020, China.

Aim: To evaluate the ophthalmic manifestations, radiographic features, and prognosis of Chinese patients with primary orbital mesenchymal chondrosarcoma (MCS).

Methods: The study included 6 cases with primary orbital MCS treated at Tianjin Eye Hospital from January 2009 to December 2019. Patitent ophthalmic manifestations, radiographic features, diagnosis, pathology, therapeutic regimens, and prognosis were retrospectively reviewed. Read More

Clin Imaging 2022 Apr 11;84:110-112. Epub 2022 Feb 11.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States of America. Electronic address:

Radiation therapy (RT) induced chondrosarcoma is a rare but important potential complication seen in cancer patients treated with radiation. Although uncommon, these patients tend to have a poor prognosis, so early detection and complete resection are the crucial steps towards survival. We present the case of an 81-year-old breast cancer patient who was treated with RT to the left chest wall. Read More

JBJS Case Connect 2022 02 16;12(1). Epub 2022 Feb 16.

Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Case: Multifocal synchronous primary skeletal chondrosarcomas of an extremity are rarely reported. In this study, we report 2 such cases. The first case is a 32-year-old woman who presented with extensive right femoral and tibial diaphysis lesions. Read More