111 results match your criteria Chondronecrosis of the Larynx


The utility of infrared thermography for evaluating lameness attributable to bacterial chondronecrosis with osteomyelitis.

Poult Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.

Bacterial chondronecrosis with osteomyelitis (BCO) is a leading cause of lameness in broilers. Infrared thermography (IRT) is a noninvasive technique for measuring infrared radiation from an object and can be used to evaluate clinical health. Two replicated studies compared the effect of light intensity on broilers grown on a wire flooring model that experimentally increased their susceptibility to and incidence of BCO lameness. Read More

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December 2018

Juvenile osteochondritis dissecans of the knee is a result of failure of the blood supply to growth cartilage and osteochondrosis.

Osteoarthritis Cartilage 2018 Dec 21;26(12):1691-1698. Epub 2018 Sep 21.

Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA. Electronic address:

Objective: Juvenile osteochondritis dissecans (JOCD) is similar to osteochondrosis dissecans (OCD) in animals, which is the result of failure of the cartilage canal blood supply, ischemic chondronecrosis and delayed ossification, or osteochondrosis. The aim of the current study was to determine if osteochondrosis lesions occur at predilection sites for JOCD in children.

Method: Computed tomographic (CT) scans of 23 knees (13 right, 10 left) from 13 children (9 male, 4 female; 1 month to 11 years old) were evaluated for lesions consisting of focal, sharply demarcated, uniformly hypodense defects in the ossification front. Read More

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December 2018
1 Read

3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.

Biomed Pharmacother 2018 Oct 30;106:1696-1704. Epub 2018 Jul 30.

Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, 710061, Shaanxi, PR China. Electronic address:

Chondrocyte is targeted for disruption in Osteoarthritis (OA) and Kashin-Beck Disease (KBD), and chondrocyte death in cartilage may contribute to the progression of OA and KBD. Oxidative stress leads to increased risk for OA. Previous work in our laboratory implicates oxidative stress as a potential mediator in children with KBD. Read More

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October 2018
8 Reads

Changes in osteogenic gene expression in hypertrophic chondrocytes induced by SIN-1.

Exp Ther Med 2018 Aug 7;16(2):609-618. Epub 2018 Jun 7.

Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, P.R. China.

The molecular mechanisms underlying osteoarthritis (OA) and Kashin-Beck disease (KBD) remain poorly understood. Hypertrophic chondrocytes serve an important role in the development of both OA and KBD, whereas oxidative stress can contribute to the pathological progression of cartilage damage. Therefore, the aim of the present study was to detect altered expression of osteogenesis-related genes in hypertrophic chondrocytes, following treatment with 3-morpholinosydnonimine (SIN-1). Read More

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August 2018
13 Reads

Septic Arthritis/Osteomyelitis May Lead to Osteochondrosis-Like Lesions in Foals.

Vet Pathol 2018 09 28;55(5):693-702. Epub 2018 May 28.

1 Norwegian University of Life Sciences, Oslo, Norway.

Failure of the cartilage canal blood supply leads to ischemic chondronecrosis which causes osteochondrosis, and osteochondral lesions. Osteochondrosis is a disease with a heritable component and usually occurs under aseptic conditions. Because bacteria can bind to growth cartilage and disrupt the blood supply in pigs and chickens, we considered whether this might play a role in development of equine osteochondrosis. Read More

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September 2018
2 Reads

Characterization of cellular and matrix alterations in the early pathogenesis of osteochondritis dissecans in pigs using second harmonic generation and two-photon excitation fluorescence microscopy.

J Orthop Res 2018 Feb 20. Epub 2018 Feb 20.

Department of Physics, Norwegian University of Science and Technology (NTNU), Høgskoleringen 5, Trondheim, 7491, Norway.

Osteochondritis dissecans is a joint disease that is observed in several species. The disease can develop as a cause of ischemic chondronecrosis in the epiphyseal growth cartilage. Some lesions of chondronecrosis undergo spontaneous resolution, but it is not possible to predict whether a lesion will resolve or progress and require intervention. Read More

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February 2018
1 Read

Escherichia coli isolates from femoral bone marrow of broilers exhibit diverse pheno- and genotypic characteristics that do not correlate with macroscopic lesions of bacterial chondronecrosis with osteomyelitis.

Avian Pathol 2018 Jun 14;47(3):271-280. Epub 2018 Mar 14.

a Clinic for Poultry and Fish Medicine, Department for Farm Animals and Veterinary Public Health , University of Veterinary Medicine , Vienna , Austria.

The pheno- and genotypic relatedness among Escherichia coli isolates from broilers with and without macroscopic lesions of the femoral head were investigated. In total, 219 isolates obtained from the bone marrow were characterized by serotyping, antimicrobial resistance (AMR) profiles, phylogenetic grouping, detection of virulence-associated genes (VAGs) and pulsed-field gel electrophoresis (PFGE). Serotyping revealed that 48. Read More

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June 2018
7 Reads

Laryngeal chondronecrosis after radiation therapy in a dog.

J Small Anim Pract 2017 Nov 30. Epub 2017 Nov 30.

College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, USA.

A 5-year-old pug presented with a soft tissue swelling on the ventral neck and moderate stridor with associated respiratory effort. This patient received hypofractionated radiotherapy for metastatic upper lip mast cell tumour and to the submandibular lymph nodes 6 months before presentation. Oral examination showed moderate elongation of the soft palate, stage III laryngeal collapse with only the right laryngeal saccule mildly everted and exuberant pale epiglottal and left pharyngeal mucosa. Read More

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November 2017
1 Read

Impact of Enteric Health and Mucosal Permeability on Skeletal Health and Lameness in Poultry.

Adv Exp Med Biol 2017 ;1033:185-197

University of Arkansas, Department of Poultry Science, Fayetteville, AR, USA.

Intestinal barrier leakage and/or altered gut microbial composition has been shown to markedly impact both osteoblast and osteoclast activities, systemically through circulation of gut immune cells and cytokines and locally by causing inflammation of extraintestinal organs such as the liver and bone marrow. Mild cases of heightened intestinal inflammation can cause bone loss in male mice in the absence of any overt nutritional deficiencies or weight loss, which has also been shown in chickens that have been infected with Salmonella. For poultry, ingredients selected for feed formulation have also a significant impact on gut health, intestinal microbiota, bone quality, and performance parameters. Read More

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April 2018
1 Read

Osteochondritis dissecans-like lesions of the occipital condyle and cervical articular process joints in a Saddlebred colt horse.

Acta Vet Scand 2017 Oct 30;59(1):76. Epub 2017 Oct 30.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA.

Background: Osteochondritis dissecans (OCD) is a sequela to osteochondrosis, whereby the cartilage superficial to the site of osteochondrosis fractures and gives rise to osteochondral fragments in the affected joint. In this case, both the radiological and computed tomography findings were supportive of classical severe OCD but the histologic findings were not supportive of the diagnosis of OCD.

Case Presentation: A 1 year and 6 months old, Saddlebred, colt was presented for evaluation of chronic cervical pain. Read More

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October 2017
14 Reads

Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis.

BMC Vet Res 2017 Aug 22;13(1):270. Epub 2017 Aug 22.

Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: Articular osteochondrosis is a common cause of leg weakness in pigs and is defined as a focal delay in the endochondral ossification of the epiphysis. The first demonstrated steps in the pathogenesis consist of loss of blood supply and subsequent chondronecrosis in the epiphyseal growth cartilage. Blood vessels in cartilage are located in cartilage canals and become incorporated into the secondary ossification centre during growth. Read More

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August 2017
3 Reads

Incubation lighting schedules and their interaction with matched or mismatched post hatch lighting schedules: Effects on broiler bone development and leg health at slaughter age.

Res Vet Sci 2017 Oct 17;114:416-422. Epub 2017 Jul 17.

Adaptation Physiology Group, Wageningen University, P.O. Box 338, 6700 AH Wageningen, The Netherlands.

The incidence of leg pathologies in broiler chickens with a developmental origin may be decreased by stimulating embryonic bone development through lighting schedules during incubation, but this may depend on post hatch lighting conditions. Aim was to investigate how lighting schedules during incubation and their interactions with matched or mismatched lighting schedules post hatch affected bone development and leg health at slaughter age. In a 3×2 factorial designed experiment, eggs were incubated under continuous cool white LED light (Inc), 16h of light, 8h of darkness (Inc), or continuous darkness (Inc) from set till hatch. Read More

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October 2017
22 Reads

Pathological and microbiological investigations into cases of bacterial chondronecrosis and osteomyelitis in broiler poultry.

Avian Pathol 2017 Dec 16;46(6):683-694. Epub 2017 Aug 16.

a Asia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences , The University of Melbourne , Werribee , Australia.

Bacterial chondronecrosis and osteomyelitis (BCO) is increasingly recognized as a major cause of lameness in commercial broilers chickens worldwide, but the pathogenesis of the condition is incompletely understood. This was a longitudinal study of 20 commercial broiler farms in Victoria, Australia, to investigate the aetiology and pathology of BCO. Thorough postmortem examination was performed on culled and dead birds (n = 325) from 20 different flocks at either 1 week, 4 weeks or 5 weeks of age and samples were analysed by conventional bacteriology, molecular identification of infectious organisms detected, serology and histopathology. Read More

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December 2017
5 Reads

Malignant tracheal necrosis and fistula formation following palliative chemoradiotherapy: a case report.

J Thorac Dis 2017 May;9(5):E402-E407

Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

Concurrent chemoradiotherapy is an essential treatment strategy for inoperable locally advanced non-small cell lung cancer (NSCLC). Although supportive care has improved, unexpected complications due to the disease or treatment can occur. Tracheomediastinal fistulas are very rare but can be a serious problem. Read More

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May 2017
9 Reads

The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers.

Animal 2017 Jun 24;11(6):1063-1070. Epub 2016 Nov 24.

2Embrapa Suínos e Aves,Rodovia BR-153,Km 110,Distrito de Tamanduá,Caixa Postal 321,89700-000,Concórdia,Santa Catarina,Brazil.

Economic losses due to an increase of leg disorders in broilers have become a major concern of the poultry industry. Despite the efforts to reduce skeletal abnormalities in chickens, insufficient progress has been made. Bacterial chondronecrosis with osteomyelitis (BCO) is one of the main disorders that affect bone integrity in broilers. Read More

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Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second-harmonic microscopy, and histological findings.

J Orthop Res 2016 10 8;34(10):1743-1752. Epub 2016 Feb 8.

Comparative Orthopaedic Research Laboratory, Faculté de médecine vétérinaire, Université de Montréal, Québec, Canada.

Osteochondrosis is an ischemic chondronecrosis of epiphyseal growth cartilage that results in focal failure of endochondral ossification and osteochondritis dissecans at specific sites in the epiphyses of humans and animals, including horses. The upstream events leading to the focal ischemia remain unknown. The epiphyseal growth cartilage matrix is composed of proteoglycan and collagen macromolecules and encases its vascular tree in canals. Read More

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October 2016
13 Reads

Chondronecrosis with osteomyelitis in broilers: Further defining a bacterial challenge model using the wire flooring model.

Poult Sci 2017 Feb 1;96(2):332-340. Epub 2016 Sep 1.

Department of Biological Sciences, University of Arkansas, Fayetteville, AR, USA, 72701

Lameness in broiler chickens is a significant animal welfare and financial issue. Bacterial chondronecrosis with osteomyelitis (BCO) leading to lameness can be enhanced by rearing young broilers on wire flooring. Using the wire floor system, we identified Staphylococcus agnetis as the predominant isolate in BCO of the proximal tibiae and femora, and blood of lame broilers. Read More

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February 2017
22 Reads

The Pathogenesis and Treatment of Legg-Calvé-Perthes Disease.

JBJS Rev 2016 07;4(7)

1Orthopaedic Research and Biotechnology, Department of Orthopaedic Surgery, Children's Hospital at Westmead, Sydney, Australia2Department of Orthopaedic Surgery, Hamad General Hospital, Doha, Qatar.

Legg-Calvé-Perthes disease is a childhood hip condition in which the blood supply to the capital femoral epiphysis is interrupted, causing osteonecrosis and chondronecrosis that lead to progressive deformity of the femoral head and secondary degenerative osteoarthritis in later life. The etiology of Legg-Calvé-Perthes disease remains unclear, with both biological and mechanical factors playing important roles in the pathogenesis of the condition. The treatment of Legg-Calvé-Perthes disease remains controversial but is dependent on several salient factors, including the age at clinical onset, the extent of epiphyseal involvement, the stage of the disease, and the degree of femoral head deformity. Read More

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July 2016
3 Reads

Imaging appearance of a post-intubation cricoid chondronecrosis.

BJR Case Rep 2016 28;2(3):20150442. Epub 2016 Jul 28.

Department of Otolaryngology, Narayana Health, Shaw Mazumdar Cancer Center, Bengaluru, India.

Chondronecrosis is a known complication of external beam radiation therapy and endotracheal intubation. Radiation therapy is the most common cause of chondronecrosis owing to local cartilage ischaemia following treatment. Prolonged endotracheal intubation can lead to chondronecrosis as it is associated with excessive pressure on the cartilage by the endotracheal tube or its cuff. Read More

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An investigation into blood microbiota and its potential association with Bacterial Chondronecrosis with Osteomyelitis (BCO) in Broilers.

Sci Rep 2016 05 13;6:25882. Epub 2016 May 13.

Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USA.

Bacterial chondronecrosis with osteomyelitis (BCO) is a common cause of lameness in commercial broiler chickens worldwide. BCO represents substantial production loss and welfare issues of chickens. The bacterial species or communities underlying BCO pathogenesis still remain to be fully characterized. Read More

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May 2016
45 Reads

Effect of different levels of dietary zinc, manganese, and copper from organic or inorganic sources on performance, bacterial chondronecrosis, intramuscular collagen characteristics, and occurrence of meat quality defects of broiler chickens.

Poult Sci 2016 Aug 29;95(8):1813-24. Epub 2016 Mar 29.

Department of Agricultural and Food Sciences, Alma Mater Studiorum - University of Bologna, Italy.

The aim of the experiment was to assess the effects of 2 dietary levels of trace minerals (TM) zinc, manganese, and copper either from organic (OTM) or inorganic (ITM) sources on broiler performance, carcass traits, intramuscular collagen (IMC) properties, occurrence of hock burns (HB), foot pad dermatitis (FPD), femoral and tibia head necrosis, and breast muscle abnormalities (white striping, WS; wooden breast, WB; poor cohesion, PC). A total of 3,600 one-day-old male chicks were randomly assigned to one of 4 dietary treatments in a 2 × 2 factorial arrangement (9 replicates of 100 birds/dietary treatment). Birds were slaughtered at 31 (thinning) and 51 d of age. Read More

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August 2016
1 Read

Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans.

Magn Reson Med 2017 03 28;77(3):1276-1283. Epub 2016 Mar 28.

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.

Purpose: To use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals in the distal femur of juvenile goats after their surgical transection.

Methods: Chondronecrosis was surgically induced in the right medial femoral condyles of four 4-day-old goats. Both the operated and control knees were harvested at 2, 3, 5, and 10 weeks after the surgeries. Read More

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March 2017
12 Reads

Differences in the vascular tree of the femoral trochlear growth cartilage at osteochondrosis-susceptible sites in foals revealed by SWI 3T MRI.

J Orthop Res 2016 09 21;34(9):1539-46. Epub 2016 Jan 21.

Comparative Orthopaedic Research Laboratory, Faculté de médecine vétérinaire, Université de Montréal, Montréal, Quebec, Canada.

Focal ischemic chondronecrosis of epiphyseal growth cartilage (EGC) during endochondral ossification is believed to be a key early event on the pathway to osteochondrosis (OC) in both animals and humans. The lateral ridge of the equine trochlea is a site where severe osteochondritis dissecans lesions frequently arise and is a model for the study of naturally occurring disease. Non-invasive imaging to investigate EGC vascularity may help elucidate why focal ischemia occurs. Read More

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September 2016
21 Reads

Genome Analysis of Staphylococcus agnetis, an Agent of Lameness in Broiler Chickens.

PLoS One 2015 25;10(11):e0143336. Epub 2015 Nov 25.

Interdisciplinary Graduate Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR, United States of America.

Lameness in broiler chickens is a significant animal welfare and financial issue. Lameness can be enhanced by rearing young broilers on wire flooring. We have identified Staphylococcus agnetis as significantly involved in bacterial chondronecrosis with osteomyelitis (BCO) in proximal tibia and femorae, leading to lameness in broiler chickens in the wire floor system. Read More

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June 2016
2 Reads

Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review.

Authors:
Robert F Wideman

Poult Sci 2016 Feb 2;95(2):325-44. Epub 2015 Nov 2.

University of Arkansas, Division of Agriculture, Fayetteville, AR, USA 72701

This review focuses on a specific cause of lameness known as bacterial chondronecrosis with osteomyelitis (BCO) in broilers. Rapid increases in body weight impose excessive torque and shear stress on structurally immature epiphyseal and physeal cartilage, primarily in the proximal femora, proximal tibiae, and flexible thoracic vertebrae. Excessive mechanical stress creates osteochondrotic clefts among the chondrocytes of susceptible growth plates. Read More

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February 2016
24 Reads

Efficacy of 25-OH Vitamin D3 prophylactic administration for reducing lameness in broilers grown on wire flooring.

Poult Sci 2015 Aug 25;94(8):1821-7. Epub 2015 Jun 25.

DSM Nutritional Products LLC, Parsippany, NJ 07054.

Bacterial chondronecrosis with osteomyelitis (BCO) is the most common cause of lameness in commercial broilers. Growing broilers on wire flooring provides an excellent experimental model for reproducibly triggering significant levels of lameness attributable to BCO. In the present study we evaluated the efficacy of adding HyD (25-OH vitamin D3) to the drinking water as a preventative/prophylactic treatment for lameness. Read More

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An Update on the Pathogenesis of Osteochondrosis.

Vet Pathol 2015 Sep 16;52(5):785-802. Epub 2015 Jun 16.

University of Minnesota, St Paul, MN, USA.

Osteochondrosis is defined as a focal disturbance in endochondral ossification. The cartilage superficial to an osteochondrosis lesion can fracture, giving rise to fragments in joints known as osteochondrosis dissecans (OCD). In pigs and horses, it has been confirmed that the disturbance in ossification is the result of failure of the blood supply to epiphyseal growth cartilage and associated ischemic chondronecrosis. Read More

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September 2015
11 Reads

Molecular survey of bacterial communities associated with bacterial chondronecrosis with osteomyelitis (BCO) in broilers.

PLoS One 2015 16;10(4):e0124403. Epub 2015 Apr 16.

Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, United States of America; Cell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, United States of America.

Bacterial chondronecrosis with osteomyelitis (BCO) is recognized as an important cause of lameness in commercial broiler chickens (meat-type chickens). Relatively little is known about the microbial communities associated with BCO. This study was conducted to increase our understanding of the microbial factors associated with BCO using a culture-independent approach. Read More

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April 2016
4 Reads

Prophylactic administration of a combined prebiotic and probiotic, or therapeutic administration of enrofloxacin, to reduce the incidence of bacterial chondronecrosis with osteomyelitis in broilers.

Poult Sci 2015 Jan;94(1):25-36

Quality Technology International, Inc., Elgin, IL 60123.

Bacteria entering the bloodstream via translocation from the gastrointestinal tract spread hematogenously and can trigger bacterial chondronecrosis with osteomyelitis (BCO) by infecting osteochondrotic microfractures in the epiphyseal-physeal cartilage of the proximal femora and tibiae. In experiment 1, broilers were fed control feed or the same feed containing BacPack 2X, which includes the prebiotic IMW50 (a mannan oligosaccharide beta-glucan yeast cell wall product) plus the probiotic Calsporin (Bacillus subtilis C-3102). Broilers reared on wire flooring consistently developed higher incidences of BCO than hatchmates reared on wood shavings litter (≥24 vs. Read More

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January 2015
1 Read

Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses.

Vet Pathol 2015 Sep 26;52(5):862-72. Epub 2014 Nov 26.

Swedish University of Agricultural Sciences, Uppsala, Sweden.

Osteochondrosis arises as a result of focal failure of the blood supply to growth cartilage. The current aim was to examine the pathogenesis of pseudocysts and true cysts in subchondral bone following failure of the blood supply to the articular-epiphyseal cartilage complex in horses. Cases were recruited based on identification of lesions (n = 17) that were considered likely to progress to or to represent pseudocysts or true cysts in epiphyseal bone in histological sections and included 10 horses ranging in age from 48 days to 5 years old. Read More

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September 2015
3 Reads

Chondronecrosis of the larynx following use of the laryngeal mask airway.

Laryngoscope 2015 Apr 24;125(4):946-9. Epub 2014 Oct 24.

Department of Otolaryngology-Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A.

This case describes the development of laryngeal chondronecrosis after use of the laryngeal mask airway (LMA). A 69-year-old male with prior laryngeal irradiation underwent total knee replacement with general anesthesia via LMA. Postoperatively, he developed laryngeal chondronecrosis, bilateral vocal fold immobility, and aspiration, necessitating tracheostomy and gastrostomy placement. Read More

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April 2015
18 Reads

Altered proteolytic activity and expression of MMPs and aggrecanases and their inhibitors in Kashin-Beck disease.

J Orthop Res 2015 Jan 26;33(1):47-55. Epub 2014 Sep 26.

Institute of Endemic Diseases, Xi'an Jiaotong University College of Medicine, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, Shaanxi, P.R., China.

Kashin-Beck disease (KBD) is a chronic, deforming endemic osteoarticular disease with altered metabolism of the cartilage matrix. Matrix metalloproteinases (MMPs), aggrecanases (ATAMTSs), and their inhibitors (TIMPs) play important roles in cartilage formation and matrix degradation. This study investigated these proteases and inhibitors in young KBD cartilage. Read More

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January 2015
24 Reads

Anatomical and biomechanical traits of broiler chickens across ontogeny. Part II. Body segment inertial properties and muscle architecture of the pelvic limb.

PeerJ 2014 3;2:e473. Epub 2014 Jul 3.

Structure & Motion Laboratory, Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London , Hatfield, Hertfordshire , UK.

In broiler chickens, genetic success for desired production traits is often shadowed by welfare concerns related to musculoskeletal health. Whilst these concerns are clear, a viable solution is still elusive. Part of the solution lies in knowing how anatomical changes in afflicted body systems that occur across ontogeny influence standing and moving. Read More

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July 2014
1 Read

Serious complication of postextubation laryngeal oedema treated by corticosteroids: septic cricoid chondronecrosis.

Eur Ann Otorhinolaryngol Head Neck Dis 2014 Nov 11;131(5):323-4. Epub 2014 Jul 11.

Service d'imagerie médicale, hôpital d'instruction des armées, 34, boulevard Laveran, CS 50004, 13384 Marseille cedex 13, France.

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November 2014
6 Reads

Evaluating portable wire-flooring models for inducing bacterial chondronecrosis with osteomyelitis in broilers.

Poult Sci 2014 Jun;93(6):1354-67

Division of Agriculture, University of Arkansas, Fayetteville 72701.

Rearing broilers on flat or sloping wire flooring is an effective method for consistently triggering lameness attributable to bacterial chondronecrosis with osteomyelitis (BCO). Portable obstacles known as speed bumps (SB) also consistently trigger modest incidences of BCO when they are installed between feed and water lines in litter flooring facilities. Two experiments were conducted to determine the most effective broiler age for introducing the SB into litter flooring pens, and to evaluate alternative configurations of the traditional SB with the expectation that amplified mechanical challenges to the legs of broilers should increase the incidence of BCO. Read More

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June 2014
1 Read

Outcome and toxicity profile after brachytherapy for squamous cell carcinoma of the nasal vestibule.

Head Neck 2015 Sep 19;37(9):1297-303. Epub 2014 Jul 19.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Background: The purpose of this study was to evaluate outcome and toxicity profile after primary brachytherapy for squamous cell carcinoma of the nasal vestibule.

Methods: A retrospective study was conducted for patients with Wang classification T1 to 2 cN0 squamous cell carcinoma of the nasal vestibule who received primary treatment with brachytherapy between 1992 and 2010. Tumor control, acute skin, mucosal, and late cartilage toxicity were scored. Read More

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September 2015
9 Reads

Bacterial chondronecrosis with osteomyelitis in broilers: influence of sires and straight-run versus sex-separate rearing.

Poult Sci 2014 Jul 7;93(7):1675-87. Epub 2014 May 7.

Cobb-Vantress Inc., Siloam Springs, AR 72761.

Two experiments (E1, E2) were conducted to compare the influence of sires (sire A on dam C vs. sire B on dam C) and straight-run versus sex-separate rearing on the incidence of bacterial chondronecrosis with osteomyelitis (BCO) in broilers. Fertile eggs from commercial breeder flocks were incubated and hatched at the University of Arkansas Poultry Research Hatchery. Read More

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Ossification defects detected in CT scans represent early osteochondrosis in the distal femur of piglets.

J Orthop Res 2014 Aug 17;32(8):1014-23. Epub 2014 Apr 17.

Norwegian School of Veterinary Science, Companion Animal Clinical Sciences, Equine Section, Ullevålsveien 72, 0454 Oslo, Norway.

The purpose of the current study was to validate the use of CT for selection against osteochondrosis in pigs by calculating positive predictive value and comparing it to the positive predictive value of macroscopic evaluation, using histological examination as the reference standard. Eighteen male, hereditarily osteochondrosis-predisposed piglets underwent terminal examination at biweekly intervals from the ages of 82-180 days old, including CT scanning, macroscopic, and histological evaluation of the left distal femur. Areas of ischemic chondronecrosis (osteochondrosis) were confirmed in histological sections from 44/56 macroscopically suspected lesions, resulting in a positive predictive value of 79% (95% CI: 67-84%). Read More

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Transoral laser microsurgery in previously irradiated patients with laryngeal cancer.

Am J Otolaryngol 2014 May-Jun;35(3):279-85. Epub 2014 Mar 12.

Department of Otolaryngology, University of Miami-Leonard M. Miller School of Medicine, Miami, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami-Leonard M. Miller School of Medicine, Miami, FL, USA.

Purpose: Early laryngeal cancer is successfully managed with transoral laser microsurgery. Previously radiated patients may experience more post-operative complications. We investigate disease-free survival and secondarily prolonged pain and chondronecrosis. Read More

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December 2014

Chondronecrosis versus recurrence: FDG PET/CT solves the dilemma in a case of locally advanced laryngeal cancer treated with definitive radiotherapy.

Indian J Nucl Med 2013 Jul;28(3):191-2

Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

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July 2013
3 Reads

Susceptibility of 4 commercial broiler crosses to lameness attributable to bacterial chondronecrosis with osteomyelitis.

Poult Sci 2013 Sep;92(9):2311-25

Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA.

Growing broilers on wire flooring provides an excellent experimental model for exposing susceptibility to lameness attributable to bacterial chondronecrosis with osteomyelitis (BCO). Two independent experiments (E1, E2) were designed to compare the susceptibilities of broilers from 4 commercial crosses (W, X, Y, and Z). The standard crosses (W and Y) grow rapidly at an early age, whereas high-yield crosses (X and Z) initially tend to grow more slowly. Read More

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September 2013
1 Read

Radiation-associated airway necrosis.

Ochsner J 2013 ;13(2):273-5

Department of Pulmonary Diseases, Critical Care, and Environmental Medicine, Tulane University Health Sciences Center, New Orleans, LA.

Background: Chondronecrosis is one of the complications that occurs after radiation treatment of the chest and mediastinal tumors, with necrosis usually developing months to years after treatment. Upper airway perichondritis and necrosis of the cricoid cartilage, larynx, and upper trachea have been observed as a complication of radiation therapy for head and neck cancers as well. Tracheal chondronecrosis, on the other hand, is a rare complication after radiation treatment. Read More

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June 2013
10 Reads

Severe valgus knee deformity caused by chondronecrosis after using a radiofrequency device.

J Orthop Sci 2014 Nov 15;19(6):1046-50. Epub 2013 May 15.

Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan,

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November 2014

Pathogenesis of epiphyseal osteochondrosis.

Vet J 2013 Jul 4;197(1):3-12. Epub 2013 May 4.

Comparative Orthopaedic Research Laboratory, Department of Clinical Sciences Faculty of Veterinary Medicine, University of Montreal, Quebec, Canada.

Osteochondrosis (OC) of the articular epiphyseal cartilage complex (AECC) is a developmental disease that is present in the first weeks of life. It is characterized by focal chondronecrosis and retention of growth cartilage due to failure of endochondral ossification. Fissures may extend from the lesion through the overlying articular cartilage to create a cartilage flap and an osteochondral fragment. Read More

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July 2013
5 Reads

Problems and pointers in osteochondrosis: Twenty years on.

Vet J 2013 Jul 30;197(1):96-102. Epub 2013 Apr 30.

Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.

Twenty years ago a supplement of Equine Veterinary Journal was devoted to equine osteochondrosis (OC) and recognised the importance of this developmental disease to the equine industry. In the accompanying editorial several controversial issues were identified and a number of areas for further research were highlighted. Today, equine OC is still a major clinical problem, but the on-going research has resulted in much improved knowledge and understanding of this highly complicated disease. Read More

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July 2013
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Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans.

Osteoarthritis Cartilage 2013 May 18;21(5):730-8. Epub 2013 Feb 18.

Norwegian School of Veterinary Science, Department of Companion Animal Clinical Sciences, Equine Section, Norway.

Objective: To transect blood vessels within epiphyseal cartilage canals and observe whether this resulted in ischaemic chondronecrosis, an associated focal delay in enchondral ossification [osteochondrosis (OC)] and pathological cartilage fracture [osteochondrosis dissecans (OCD)] in the distal femur of foals, with potential translational value to the pathogenesis of juvenile osteochondritis dissecans (JOCD) in children.

Method: Ten Norwegian Fjord Pony foals were operated at the age of 13-15 days. Two vessels supplying the epiphyseal growth cartilage of the lateral trochlear ridge of the left distal femur were transected in each foal. Read More

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May 2013
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Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis.

Front Endocrinol (Lausanne) 2012 22;3:183. Epub 2013 Jan 22.

Center of Excellence for Poultry Science, University of Arkansas Fayetteville, AR, USA.

This review provides a comprehensive overview of the vascularization of the avian growth plate and its subsequent role in the pathogenesis of bacterial chondronecrosis with osteomyelitis (BCO, femoral head necrosis). BCO sporadically causes high incidences of lameness in rapidly growing broiler (meat-type) chickens. BCO is believed to be initiated by micro-trauma to poorly mineralized columns of cartilage cells in the proximal growth plates of the leg bones, followed by colonization by hematogenously distributed opportunistic bacteria. Read More

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January 2013
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Dexamethasone triggers lameness associated with necrosis of the proximal tibial head and proximal femoral head in broilers.

Poult Sci 2012 Oct;91(10):2464-74

University of Arkansas, Division of Agriculture, Fayetteville, AR, USA.

Bacterial chondronecrosis with osteomyelitis (BCO) and turkey osteomyelitis complex (TOC) are characterized by bacterial infection and necrotic degeneration within the tibiae and femora. Stress and immunosuppression have been implicated in the pathogenesis of BCO and TOC. Immunosuppressive doses of dexamethasone (DEX) trigger high incidences of TOC in turkey poults. Read More

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October 2012

Selenium promotes proliferation of chondrogenic cell ATDC5 by increment of intracellular ATP content under serum deprivation.

Cell Biochem Funct 2012 Dec 29;30(8):657-63. Epub 2012 May 29.

Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, China.

Selenium (Se) is an essential micronutrient, and low Se intake in Se-deficient areas plays roles in an endemic osteochondropathy characterized by chondronecrosis in growth plate and articular cartilage. However, the biological activities of Se on cartilage are largely unknown. In this study, we examined the effects of Se on chondrogenic cell ATDC5 and the possible mechanisms involved. Read More

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December 2012
4 Reads

Cricoid chondronecrosis: a complication of endotracheal intubation.

J Ark Med Soc 2012 Feb;108(9):192-4

Stenosis of the subglottic area is a common complication of endotracheal intubation and external blunt trauma. Chondronecrosis of the cricoid cartilage is a rare but known complication of neck radiotherapy for laryngeal carcinoma. It has also been reported as a complication of prolonged endotracheal intubation. Read More

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February 2012
6 Reads