31 results match your criteria Chondronecrosis of the Larynx

Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes.

Cancers (Basel) 2022 May 24;14(11). Epub 2022 May 24.

Division of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, Italy.

The aim of the present study was to investigate the role of intensity-modulated radiotherapy (IMRT) on the toxicity profile of patients treated with conservative surgery (CS) of the supraglottic (SG) region. Data on patients treated with CS and postoperative radiotherapy (PORT)-IMRT were prospectively collected. Results. Read More

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Cricoid Chondronecrosis: Case Report and Review of Literature.

Ann Otol Rhinol Laryngol 2020 Jul 18;129(7):662-668. Epub 2020 Feb 18.

University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: Cricoid chondronecrosis is a rare entity that has significant consequences for patients. Reports of its occurrence are scattered in the literature and currently there is no comprehensive review to help guide providers.

Methods: A case report from our institution is presented. Read More

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Chondroradionecrosis of the larynx.

Curr Opin Otolaryngol Head Neck Surg 2019 Dec;27(6):463-466

ENT Clinic.

Purpose Of Review: Purpose of the present review is to revise the literature of the last 18 months, looking for novelties or new trends in diagnosis and therapeutical approaches to a very uncommon complicaton.

Recent Findings: Some comorbidities as well as prior surgical laryngeal treatment and lifestyle factors are known to increase tissue susceptibility to radiation injury and to complications due to endotracheal intubation.

Summary: Chondroradionecrosis (CRN) of the larynx is a rare and severe complication of radiotherapy and endotracheal intubation which can be fatal if not managed promptly. Read More

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December 2019

Arytenoid Expectoration After Radiotherapy: A Rare Complication of Laryngeal Chondronecrosis.

Ear Nose Throat J 2020 03 7;99(3):181-182. Epub 2019 Apr 7.

Division of Laryngology and Voice Care, Department of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville, VA, USA.

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Laryngeal chondronecrosis after radiation therapy in a dog.

J Small Anim Pract 2018 Dec 30;59(12):783-787. Epub 2017 Nov 30.

College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, USA.

A 5-year-old pug presented with a soft tissue swelling on the ventral neck and moderate stridor with associated respiratory effort. This patient received hypofractionated radiotherapy for metastatic upper lip mast cell tumour and to the submandibular lymph nodes 6 months before presentation. Oral examination showed moderate elongation of the soft palate, stage III laryngeal collapse with only the right laryngeal saccule mildly everted and exuberant pale epiglottal and left pharyngeal mucosa. Read More

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December 2018

Chondronecrosis of the larynx following use of the laryngeal mask airway.

Laryngoscope 2015 Apr 24;125(4):946-9. Epub 2014 Oct 24.

Department of Otolaryngology-Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A.

This case describes the development of laryngeal chondronecrosis after use of the laryngeal mask airway (LMA). A 69-year-old male with prior laryngeal irradiation underwent total knee replacement with general anesthesia via LMA. Postoperatively, he developed laryngeal chondronecrosis, bilateral vocal fold immobility, and aspiration, necessitating tracheostomy and gastrostomy placement. Read More

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Serious complication of postextubation laryngeal oedema treated by corticosteroids: septic cricoid chondronecrosis.

Eur Ann Otorhinolaryngol Head Neck Dis 2014 Nov 11;131(5):323-4. Epub 2014 Jul 11.

Service d'imagerie médicale, hôpital d'instruction des armées, 34, boulevard Laveran, CS 50004, 13384 Marseille cedex 13, France.

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November 2014

Radiation-associated airway necrosis.

Ochsner J 2013 ;13(2):273-5

Department of Pulmonary Diseases, Critical Care, and Environmental Medicine, Tulane University Health Sciences Center, New Orleans, LA.

Background: Chondronecrosis is one of the complications that occurs after radiation treatment of the chest and mediastinal tumors, with necrosis usually developing months to years after treatment. Upper airway perichondritis and necrosis of the cricoid cartilage, larynx, and upper trachea have been observed as a complication of radiation therapy for head and neck cancers as well. Tracheal chondronecrosis, on the other hand, is a rare complication after radiation treatment. Read More

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Cricoid chondronecrosis: a complication of endotracheal intubation.

J Ark Med Soc 2012 Feb;108(9):192-4

Stenosis of the subglottic area is a common complication of endotracheal intubation and external blunt trauma. Chondronecrosis of the cricoid cartilage is a rare but known complication of neck radiotherapy for laryngeal carcinoma. It has also been reported as a complication of prolonged endotracheal intubation. Read More

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February 2012

Transoral laser microsurgery for recurrence after primary radiotherapy of early glottic cancer.

Auris Nasus Larynx 2010 Aug 23;37(4):474-81. Epub 2009 Dec 23.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen, Göttingen, Germany.

Objective: To analyze oncological results of transoral laser microsurgery (TLM) on recurrent early glottic cancer after primary radiotherapy.

Methods: The records of 53 patients treated by TLM for early (rTis-rT2) and advanced (rT3, rT4) recurrence after curative radiotherapy were retrospectively analyzed. Data on loco-regional control, overall survival, and disease specific survival were calculated by the Kaplan-Meier method. Read More

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[Laryngeal chondronecrosis following radiotherapy and concurrent chemotherapy].

Acta Otorrinolaringol Esp 2008 Dec;59(10):509

Servicio de Otorrinolaringología. Hospital de Fuenlabrada. Madrid. España.

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December 2008

Supracricoid laryngectomy with cricohyoidopexy for recurrence of early-stage glottic carcinoma after irradiation. Long-term oncological and functional results.

Acta Otolaryngol 2005 Jan;125(1):91-5

Departments of Otolaryngology--Head and Neck Surgery, University of Padua, Padua, Italy.

Conclusions: These results suggest that, in selected cases, SCL-CHP may be used to treat laryngeal carcinomas after radiation failure, with good oncological and functional results.

Objectives: Radiotherapy and surgery are believed to be equally effective and highly successful in the management of T1-staged glottic carcinomas. An almost normal post-therapy voice is considered the main advantage of irradiation over the surgical approach. Read More

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January 2005

Late post radiation laryngeal chondronecrosis with pharyngooesophageal fibrosis.

Indian J Cancer 2004 Apr-Jun;41(2):81-4

Department of Surgical Oncology, Regional Cancer Centre, Trivandrum-695011, India.

Chondroradionecrosis of larynx is a well recognized complication of radiation therapy, which usually occur with in the 1st year. Review of literature shows very few accounts of late radiation induced clinical chondroradionecrosis of the larynx. This condition can mimic a local recurrence and severe and life threatening involvement will require aggressive surgical management as reported in the present case. Read More

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Transoral carbon dioxide laser microsurgery for recurrent glottic carcinoma after radiotherapy.

Head Neck 2004 Jun;26(6):477-84

Department of Otorhinolaryngology, Universitäts-HNO-Klinik, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.

Background: Transoral laser microsurgery is successfully performed in the treatment of primary laryngeal carcinomas. Few publications deal with the application in patients with recurrent glottic carcinomas after radiation failure. Our study aims to review our experience with transoral laser microsurgery in these patients. Read More

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Late laryngo-tracheal cartilage necrosis with external fistula 44 years after radiotherapy.

J Laryngol Otol 2003 Aug;117(8):658-9

Department of Otolaryngology, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.

Major late complications, following radiotherapy of head and neck carcinomas, such as laryngeal oedema, perichondritis and chondronecrosis usually occur between three and 12 months after treatment. However, the present case displayed necrosis of the laryngo-tracheal cartilage and ulceration of anterior neck skin with a tracheal fistula 44 years after irradiation. The reasons for the long interval between irradiation and late complications may be explained by long-standing hypovascularity and/or infection of the irradiated area. Read More

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A case of chondronecrosis of the epiglottis after laser chordotomy.

Eur Arch Otorhinolaryngol 2002 Nov 26;259(10):524-6. Epub 2002 Jun 26.

Department of Otorhinolaryngology, Friedrich Schiller University of Jena, Lessingstrasse 2, 07740 Jena, Germany.

A 30-year-old Caucasian female patient suffering from bilateral vocal-fold immobility developed a necrosis of the epiglottis with severe respiratory distress 35 days after fiber-guided Nd:YAG-laser chordotomy on the right side. Twenty-two years prior to surgery, she had received a high-dose radiotherapy, which had caused severe scarring of the whole neck and the larynx. This necrosis is more likely an inflammatory complication than a direct side effect of the laser surgery in the radiation-altered laryngeal tissue. Read More

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November 2002

[Cricoid chondronecrosis after prolonged endotracheal intubation].

J Radiol 2002 Feb;83(2 Pt 1):161-4

Plateau commun d'imagerie, Centre sud, 9037 Lille, Cedex, France.

Subglottic area injuries after prolonged endotracheal intubation are relatively frequent but cricoid cartilage necrosis is rare, with uncertain prognosis. Endoscopic findings are evocative even when clinical signs are not. When suspected, CT scan is required. Read More

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February 2002

Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma.

Int J Radiat Oncol Biol Phys 2000 Dec;48(5):1489-95

Department of Radiology, Division of Radiation Oncology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.

Purpose: To examine the long-term effects of treatment in children receiving radiotherapy for head and neck rhabdomyosarcoma.

Methods: From 1967 to 1994, a total of 30 children with head and neck rhabdomyosarcoma received megavoltage radiotherapy at one institution. Seventeen patients (57%) have survived and have at least a 5-year follow-up. Read More

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December 2000

Chondronecrosis of the cricoid cartilage after intubation. Two case reports.

Eur J Anaesthesiol 1997 Jul;14(4):461-3

Département d'Anesthésie-Réanimation chirurgicale 2, Hôpital Claude Huriez, CHRU Lille, France.

Chondronecrosis of the cricoid cartilage is a rare complication of intubation. The records of two children were reviewed. An 8-month-old girl with myelomonocytic leukaemia developed chondronecrosis 10 days after a 2-day period of ventilation. Read More

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Radical radiotherapy for T3 laryngeal cancers.

Strahlenther Onkol 1996 Aug;172(8):422-6

Department of Radiation Therapy and Oncology, International Medical Center of Japan, Tokyo.

Purpose: Evaluation of the local control rate and voice preservation probability in radically irradiated patients with T3 laryngeal cancer.

Patients And Methods: From 1974 through 1992, 37 previously untreated patients with T3 laryngeal cancer (supraglottic 15, glottic 22) were treated with initial radical radiotherapy and surgery for salvage.

Results: Two-year local control rate with radiotherapy alone, ultimate voice preservation rate, and ultimate local control rate for T3 supraglottic cancer were 33%, 33%, and 60%, respectively. Read More

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[Post-radiation necrosis of the cricoid cartilage: an uncommon case].

J Radiol 1995 Aug;76(8):517-20

Service de Radiologie, Hôpital Saint-Antoine, Paris.

Radiation therapy is considered as the treatment of choice for early stage laryngeal cancer. However, a few patients, after several years, develop severe life threatening complications, like edema or chondronecrosis. The clinical examination or endoscopy follow up may be difficult. Read More

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[Regarding assessment of changes in the larynx after radiation according to RTOG/EORTC classification].

Otolaryngol Pol 1995 ;49 Suppl 20:367-73

Oddziału Otolaryngologicznego, Szpitala Miejskiego im. J. Brudzinskiego, Gdyni.

The authors discuss the classification of changes in reactions occurring during and after radiotherapy of the laryngeal cancer adopted in 1987 by Radiation Therapy Oncology Group and European Organisation for Research and Treatment of Cancer (RTOG/EORTC). The above classification is not based on uniform criteria. The authors express the opinion that is extremely difficult to distinguish between chondritis, chondronecrosis of high intensity and necrosis without microscopic examination and limiting oneselves to the subjective symptoms only. Read More

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February 1998

Pectoralis major muscle transposition: an adjunct to laryngeal preservation in severe chondroradionecrosis.

J Laryngol Otol 1993 Aug;107(8):748-51

Department of ENT/Head and Neck Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam.

Radiation-induced chondronecrosis of the larynx in early glottic cancer is a rare but serious complication, sometimes requiring total laryngectomy. We describe two patients who developed the major complication of chondroradionecrosis of the larynx 11 and 18 years after completion of radiotherapy. Both cases underwent excision of the overlying skin and of all infected and devitalized thyroid cartilage, followed by pectoralis major muscle transposition and split thickness skin grafting. Read More

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Twice-a-day radiation therapy for cancer of the head and neck.

Cancer 1985 May;55(9 Suppl):2100-4

Experience with the twice-a-day (BID) radiation therapy program for carcinomas of the head and neck areas is presented. The program consists of 1.6 Gy per fraction, two fractions per day with 4 hours between fractions, for 12 days, 5 days a week. Read More

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[J. Evan's operation for stenosis caused by cricoid chondronecrosis].

J Desnos J Dubin

Ann Otolaryngol Chir Cervicofac 1984 ;101(3):213-6

Five further cases of subglottic stenosis after intubation are reported. Lesions were due to chondrolysis of the cricoid cartilage: associating an Evans type anterior laryngotracheoplasty (the principle of which is recalled) with the posterior cricoid incision of the Rethi-Aboulker type produced a marked improvement in the results of posterior laryngoplasty performed alone. Read More

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September 1984

Histopathological study of radionecrosis in laryngeal carcinoma.

Laryngoscope 1982 Feb;92(2):173-80

With modern radiotherapy techniques, clinical radionecrosis is uncommon following eradication of primary squamous cell carcinoma from the larynx. Histologic sections from 265 specimens, prepared by the technique of whole organ subserial step-sectioning were studied to determine the incidence and location of chondronecrosis and/or osteomyelitis in both irradiated and non-irradiated cases. Chondronecrosis occurred in only 1 of 41 early (pT1 - pT2) tumors but in 143 advanced tumors (pT - pT4) treated with radical radiotherapy and containing residual carcinoma, 27% had evidence of significant necrosis, compared with 24% of those not irradiated. Read More

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February 1982

[Chondronecrosis of the cricoid after prolonged intubation (author's transl)].

Ann Otolaryngol Chir Cervicofac 1980 Sep;97(9):711-24

On the basis of 4 cases of partial chondronecrosis of the cricoid after prolonged intubation, the authors review the literature which contains very few similar cases. With regard to pathogenesis, in the light of experimental studies and clinical findings, they emphasize the importance of two lesional factors: excessive diameter of the intubation tube and excessive deflection of the patients' head. All of these factors increase the pressure applied by the tube to the region inferior to the posterior commissure. Read More

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September 1980

Preservation of a radionecrotic larynx by excision of thyroid cartilage with flap coverage.

W B Litton

Laryngoscope 1978 Dec;88(12):1947-9

Necrosis of the larynx following radiation therapy is a rare complication leading to severe disability and even death. Generally accepted treatment has consisted of incision and drainage, debridement, and tracheotomy or even total laryngectomy. One patient developed chondronecrosis of the thyroid cartilage and was treated by excision of the entire thyroid cartilage and overlying skin with subsequent coverage by a unipedicled cervicothoracic flap. Read More

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December 1978