719 results match your criteria Chondromyxoid Fibroma

Primary Orbital Chondromyxoid Fibroma: A Cause of Monosymptomatic Periocular Pain.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):193-197. Epub 2021 Apr 12.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Chondromyxoid fibroma (CMF) is a very rare entity, accounting for <1% of all bone tumours. So far, only 4 cases have been reported with the orbit as primary location. Here, we present a case of orbital CMF with periocular pain as the presenting symptom and as the only symptom when the tumour recurred after surgery. Read More

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Rare histologic presentation of pleomorphic adenoma: A diagnostic dilemma.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):563-567. Epub 2021 Jan 9.

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute University, Chennai, Tamil Nadu, India.

Pleomorphic adenoma is the most common benign salivary gland tumor deriving its name from varied morphological patterns in histopathology. The presence of chondromyxoid stroma in histopathology is characteristic of pleomorphic adenoma. Cellular variants without characteristic chondromyxoid stroma are rare and often pose a diagnostic challenge. Read More

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January 2021

Cytopathology of chondromyxoid fibroma: a case series and review of the literature.

J Am Soc Cytopathol 2021 Apr 7. Epub 2021 Apr 7.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Introduction: Chondromyxoid fibroma is a rare bone tumor characterized by immature myxoid mesenchymal tissue showing early primitive cartilaginous differentiation. There have been limited case reports describing the cytologic features of chondromyxoid fibroma. Herein, we reported cytologic features of chondromyxoid fibroma on fine-needle aspiration (FNA). Read More

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RREB1-MKL2 fusion in a spindle cell sinonasal sarcoma: biphenotypic sinonasal sarcoma or ectomesenchymal chondromyxoid tumor in an unusual site?

Genes Chromosomes Cancer 2021 Mar 14. Epub 2021 Mar 14.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Biphenotypic sinonasal sarcoma (BSNS) is a rare, low grade spindle cell sarcoma, recently recognized in the WHO classification of head and neck tumors, which is characterized by a dual myogenic and neural differentiation and recurrent gene fusions, often involving PAX3-MAML3, and less commonly PAX3 fusions with other partners such as NCOA1, NCOA2, or WWTR1. Yet, in about 4% of tumors no gene rearrangements are identified. Herein, we describe a RREB1-MKL2 fusion in a BSNS lesion occurring in a 73-year-old female patient with a right maxillo-ethmoidal angle lesion. Read More

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BOC-PLAG1, a new fusion gene of pleomorphic adenoma: Identified in a fine-needle aspirate by RNA next-generation sequencing.

Diagn Cytopathol 2021 Jun 12;49(6):790-792. Epub 2021 Mar 12.

Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Fine-needle aspiration (FNA) of PA exhibits variable combinations of bland ductal epithelial cells, myoepithelial cells, and characteristic magenta fibrillary stroma on Diff-Quik/Romanowsky stain. However, a cellular PA with scant chondromyxoid stroma can be a diagnostic challenge on FNA. Read More

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Ectomesenchymal chondromyxoid tumour on the lateral border of the tongue: some historical and clinical considerations.

Int J Oral Maxillofac Surg 2021 Mar 1. Epub 2021 Mar 1.

Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama, Japan.

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Response to Letter to the Editor "Ectomesenchymal chondromyxoid tumour on the lateral border of the tongue: some historical and clinical considerations".

Int J Oral Maxillofac Surg 2021 Feb 27. Epub 2021 Feb 27.

Division of Oral Pathology, Faculty of Dentistry and Graduate School of Medical and Dental Science, Niigata University, Niigata City, Niigata, Japan.

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February 2021

H3.3 K36M Mutation as a Clinical Diagnosis Method of Suspected Chondroblastoma Cases.

Orthop Surg 2021 Apr 23;13(2):616-622. Epub 2021 Feb 23.

Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Whether H3.3 K36M mutation (H3K36M) could be an approach if the diagnosis of chondroblastoma (CB) patients was indistinct and it was suspected to be unclear clinically.

Methods: We reviewed and compared our clinical experiences of CB cases and some suspected cases, which were not diagnosed distinctly, between 2013 to 2019. Read More

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Calcifying Pseudoneoplasm of the Neuraxis Involving the Posterior Skull Base: A Case Report and Literature Review.

Int J Surg Pathol 2021 Jan 19:1066896921988935. Epub 2021 Jan 19.

University of Texas Health San Antonio, TX, USA.

Calcifying pseudoneoplasm of the neuraxis is an uncommon, nonneoplastic fibro-osseous lesion of the central nervous system. At the time of this report, at least 150 cases have been reported in the literature. Because of the rarity of this lesion, it is often diagnostically challenging for radiologists and pathologists alike. Read More

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January 2021

YJ5 as an immunohistochemical marker of osteogenic lineage.

Pathology 2021 Feb 10;53(2):229-238. Epub 2020 Nov 10.

Department of Pathology, National University Singapore, Singapore. Electronic address:

Overexpression of WLS, an upstream protein in the Wnt pathway, has been implicated in several non-osteogenic tumours. This study represents the first attempt at evaluating WLS expression in various bone and soft tissue tumours using YJ5, a monoclonal antibody specific to WLS, with the aim of elucidating its utility in discerning tumours with aberrant Wnt signalling and as a marker of osteogenic lineage in challenging cases. Tumour tissue sections of 144 bone mass lesions and 63 soft tissue mass lesions were immunostained with the YJ5 antibody following standardised protocols. Read More

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February 2021

Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital.

Acta Cytol 2021 12;65(1):75-87. Epub 2020 Nov 12.

Department of Orthopaedics, Nizams Institute of Medical Sciences, Hyderabad, India.

Aim: The aim is to study the utility of fine-needle aspiration cytology (FNAC) in preoperative diagnosis of bone lesions in correlation with radiological and histopathological findings and to determine the spectrum and morphological features of various bone lesions on FNAC.

Materials And Methods: A total of 275 cases of bone lesions were studied by FNAC over a period of 3 years. 196 procedures were performed by pathologists, and 107 procedures were guided. Read More

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January 2021

Chondromyxoid fibroma of the nasal cavity - A rare tumor at an unusual site.

Indian J Pathol Microbiol 2020 Oct-Dec;63(4):656-657

Department of ENT, Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

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November 2020

Sclerosing epithelioid fibrosarcoma of bone: morphological, immunophenotypical, and molecular findings of 9 cases.

Virchows Arch 2021 Apr 21;478(4):767-777. Epub 2020 Oct 21.

Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.

Primary sclerosing epithelioid fibrosarcoma (SEF) of bone is a rare and scarcely reported neoplasm. We document clinicopathological and molecular features of 9 additional cases. Five males and 4 females had a mean age of 39 years (14-71 years). Read More

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H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors.

Histol Histopathol 2021 Jan 4;36(1):61-68. Epub 2020 Sep 4.

Department of Pathology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, China.

H3F3A mutations and the expression of glycine 34 to tryptophan (G34W) mutants in giant cell tumors of bone (GCTBs) and other bone tumors were detected to compare H3F3A mutation types and the expression of G34W-mutant protein in order to provide a theoretical basis for using H3F3A mutations as a diagnostic and differential-diagnostic tool for GCTBs. A total of 366 bone tumor cases were investigated. The cases involved 215 men and 151 women, whose median age was 29 years (3-84). Read More

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January 2021

Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature.

Case Rep Dent 2020 31;2020:8828775. Epub 2020 Aug 31.

Department of Basic Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Salivary gland tumors (SGT) comprise 3% of all head and neck tumors, are mostly benign, and arise frequently in the parotid gland. Pleomorphic adenoma (PA) is the commonest SGT, representing 60-70% of all benign parotid tumors. Clinically, parotid PA presents as irregular, lobulated, asymptomatic, slow-growing preauricular mass, involving both superficial and deep lobes, and could grow to gigantic proportions. Read More

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Extraskeletal myxoid chondrosarcoma: combining cytopathology with molecular testing to achieve diagnostic accuracy.

Paul E Wakely

J Am Soc Cytopathol 2021 May-Jun;10(3):293-299. Epub 2020 Jul 31.

Department of Pathology, James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Introduction: Advances in the genetics of soft tissue neoplasia have allowed for the diagnostic recognition of specific tumor types from small biopsy specimens, including those procured using the fine needle aspiration (FNA) biopsy technique. Extraskeletal myxoid chondrosarcoma (EMC) is a malignant mesenchymal neoplasm characterized by NR4A3 and, less specifically, by EWSR1 gene rearrangements. A series of EMC cytologic specimens was examined to demonstrate the diagnostic value of incorporating fluorescence in situ hybridization (FISH) testing in cytologic cases of suspected EMC. Read More

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Subperiosteal chondromyxoid fibroma: a rare case involving the humeral diaphysis.

Skeletal Radiol 2021 Mar 15;50(3):597-602. Epub 2020 Aug 15.

Department of Radiology, University of Ottawa, Ottawa, ON, K1H 8L6, Canada.

Initially described, in 1948, as a tumor that could be mistaken with chondrosarcoma at histopathology, chondromyxoid fibroma is now a well-recognized entity. Surface-type chondromyxoid fibroma, however, remains an extremely rare occurrence. We present a case of a 55-year-old woman, who experienced right arm pain for 5 years. Read More

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Metastatic Epithelial-Myoepithelial Carcinoma in a Female Presenting with Neck Mass and Lytic Lesion in Acetabulum: A Diagnostic Challenge on Cytology.

Turk Patoloji Derg 2021 ;37(1):84-88

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, CHANDIGARH, INDIA.

Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant salivary neoplasm. Establishing an accurate cytological diagnosis is often challenging owing to its rarity, bland cytologic appearance and variable representation of cell populations in the smears. The diagnostic struggle is more so when the aspiration is from a metastatic site with an unknown primary, as in such cases the list of differential diagnoses expands further. Read More

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January 2021

Cutaneous Myoepithelioma: An Unusual Tumor in the Hand.

Case Rep Pathol 2020 14;2020:3747013. Epub 2020 Jun 14.

Facultad de Ciencias Médicas de la Salud y la Vida, Escuela de Medicina, Docencia y Departamento de Investigación, Universidad Internacional del Ecuador, Quito, Ecuador.

Cutaneous myoepithelioma (CM) is a rare tumor among the primary skin neoplasms. We present the case of a patient with a diagnosis of CM in the right hypothenar region. Histological study showed a proliferation of myoepithelial cells with a solid, reticular growth pattern in a chondromyxoid stroma. Read More

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Expanding Awareness of the Distribution and Biologic Potential of Ectomesenchymal Chondromyxoid Tumor.

Head Neck Pathol 2021 Mar 5;15(1):319-322. Epub 2020 May 5.

Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Ectomesenchymal chondromyxoid tumor is a rare neoplasm of uncertain histogenesis that typically occurs in the anterior dorsal tongue. Recent reports in the literature have described rare examples of gingival, palatal and tonsillar lesions. Histologically, ectomesenchymal chondromyxoid tumors are typically well-circumscribed, lacking overtly aggressive features. Read More

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An ectomesenchymal chondromyxoid tumour on the lateral border of the tongue.

Int J Oral Maxillofac Surg 2020 Oct 4;49(10):1290-1293. Epub 2020 May 4.

Division of Oral Pathology, Faculty of Dentistry and Graduate School of Medical and Dental science, Niigata University, Niigata, Japan.

Ectomesenchymal chondromyxoid tumour (ECT) is an extremely rare intraoral mesenchymal tumour. Most of these tumours have been identified on the anterior aspect of the dorsal surface of the tongue. ECT is difficult to diagnose because of its rarity. Read More

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October 2020

Chondromyxoid Fibroma of the Sacral Spine.

Int J Surg Pathol 2020 Oct 4;28(7):799-803. Epub 2020 May 4.

Rutgers New Jersey Medical School, Newark, NJ, USA.

. Chondromyxoid fibromas are rare tumors of cartilaginous origin typically found in long bones. They usually present during the second and third decades of life. Read More

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October 2020

Chondromyxoid Fibroma of Distal Phalanx of the Great Toe: A Rare Clinical Entity.

Cureus 2020 Feb 28;12(2):e7133. Epub 2020 Feb 28.

Orthopaedics, Siddhartha Medical College, Vijayawada, IND.

Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for approximately 1% of bone tumors. Metaphysis of long bones is the most common location of this tumor. Read More

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February 2020

Chondromyxoid Fibroma of the Mastoid: A Rare Entity with Comprehensive Literature Review.

J Int Adv Otol 2020 Apr;16(1):117-122

Department of Otorhinolaryngology, University Hospital Antwerp, University of Antwerp, Antwerp, Belgium.

Chondromyxoid fibroma (CMF) is the least commonly occurring bone tumor of cartilaginous origin. It is usually situated in the metaphysis of long bones of the lower limbs. Localization of the tumor in the skull is extremely rare. Read More

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Chondromyxoid fibroma of the temporal bone: A rare case report.

Medicine (Baltimore) 2020 Mar;99(11):e19487

Department of Otorhinolaryngology, Beijing Tongren Hospital.

Rationale: Chondromyxoid fibroma (CMF) is a rare form of benign bone tumor and easily misdiagnosed as fibrosarcoma. Hence, to explore the clinical manifestations, diagnostic tests, and therapeutic procedures for temporal bone cartilage myxoid fibroma, it is important to optimize patient treatment and avoid overtreatment. Previous research has discussed cases of CMF, but this paper presents a systematic, complete, and comprehensive introduction of this disease based on this case and related literature. Read More

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Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases.

Clin Imaging 2020 Jun 30;62:23-32. Epub 2020 Jan 30.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, United States of America.

Purpose: To describe the imaging, anatomic, and clinical features of a series of secondary aneurysmal bone cysts (ABC) and to ascertain their most commonly associated primary bone lesions.

Methods: Forty-nine cases of histopathologically proven secondary ABCs were retrospectively reviewed. Demographic data and clinical history were obtained. Read More

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Excisional Curettage of Benign Cystic Lesions.

JBJS Essent Surg Tech 2019 Jul-Sep;9(3):e24. Epub 2019 Jul 10.

Department of Orthopaedics and Rehabilitation, Yale New Haven Hospital, New Haven, Connecticut.

There are many treatment modalities for benign cystic lesions of bone, but all methods, except for total resection, are plagued with varying rates of recurrence. Thorough curettage with the use of a high-speed burr, however, has demonstrated a low recurrence rate of 12% and has been suggested to be the best method for the treatment of benign cystic lesions. Approximately 90% of aneurysmal bone cysts can be controlled adequately with this treatment alone. Read More

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Chondromyxoid fibroma-like osteosarcoma: a case series and literature review.

BMC Musculoskelet Disord 2020 Jan 29;21(1):53. Epub 2020 Jan 29.

Department of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, 200050, China.

Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an exceedingly rare subtype of low-grade central osteosarcoma (LGCO), accounting for up to 10% of cases and making it difficult to diagnose. CMF-OS is frequently misdiagnosed on a radiological examination and biopsy, even after the initial operation. Its treatment is a controversial issue due to its low-grade classification and actual high-grade behavior. Read More

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January 2020

Mesenchymal tumours with RREB1-MRTFB fusion involving the mediastinum: extra-glossal ectomesenchymal chondromyxoid tumours?

Histopathology 2020 Jun 22;76(7):1023-1031. Epub 2020 May 22.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Aims: Ectomesenchymal chondromyxoid tumour (ECT) is a rare benign intraoral tumour which almost exclusively presents as a small mass of the anterior dorsal tongue. Recently, the RREB1-MRTFB (previously known as MKL2) fusion gene has been identified in 90% of ECTs, all located in the tongue, emphasising its genetic distinctiveness. Here, we report two mesenchymal tumours involving the superior mediastinum of adult women with RREB1-MRTFB fusions. Read More

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Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor.

Am J Case Rep 2020 Jan 27;21:e920702. Epub 2020 Jan 27.

Department of Gastrointestinal Surgery, Hokkaido Cancer Center, Sapporo, Hokkaido, Japan.

BACKGROUND Myoepithelioma is a rare neoplasm that differentiates toward myoepithelial cells. This condition mainly occurs in the salivary gland and rarely in the  soft tissue or internal organs. Long-term survival with repeated multiple rounds of resection for recurrence is rarely reported. Read More

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January 2020