552 results match your criteria Chondromyxoid Fibroma


Approach to Primary Vertebral Tumors in the Light of the 2020 Updated World Health Organization Classification of Bone Tumors.

Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Umraniye Education and Research Hospital, Department of Pathology, Istanbul, Turkey.

Aim: The spinal canal frequently harbors primary and secondary bone tumors. These tumors have specific localization, age range, and clinical and radiological manifestations, and their treatment requires a multidisciplinary approach. In most cases, a definitive diagnosis is made based on clinical, radiological, and histopathological findings. Read More

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December 2021

GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.

Am J Surg Pathol 2022 Jun 1. Epub 2022 Jun 1.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that manifests histologically as a lobular proliferation of stellate to spindle-shaped cells in a myxoid background, exhibiting morphologic overlap with other cartilaginous and myxoid tumors of bone. CMF is characterized by recurrent genetic rearrangements that place the glutamate receptor gene GRM1 under the regulatory control of a constitutively active promoter, leading to increased gene expression. Here, we explore the diagnostic utility of GRM1 immunohistochemistry as a surrogate marker for GRM1 rearrangement using a commercially available monoclonal antibody in a study of 230 tumors, including 30 CMF cases represented by 35 specimens. Read More

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Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.

Virchows Arch 2022 May 25. Epub 2022 May 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the RAS/MAPK pathway. However, NOF is located in the long bones with regression after puberty in contrast to CGCG which is located in the jaw bones and does not regress spontaneously. We hypothesised that endocrine regulation by oestrogen plays a role in the spontaneous regression in NOF. Read More

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Treatment of locally aggressive benign bone tumors by means of extended intralesional curettage without chemical adjuvants.

SAGE Open Med 2022 22;10:20503121221094199. Epub 2022 Apr 22.

Department of Orthopedics and Traumatology, Marmara University Pendik Training and Research Hospital, İstanbul, Turkey.

Objectives: The aim of this study is to present the clinical, oncological, and functional results of locally aggressive benign bone tumors treated with extended intralesional curettage without the use of adjuvant in a tertiary orthopedic oncology center.

Method: A total of 172 patients treated with surgical curettage and high-speed burrs for the diagnosis of aneurysmal bone cyst, giant cell tumor, osteoblastoma, chondroblastoma, and chondromyxoid fibroma were included in the study. Demographic, radiological, and clinical data of the patients were analyzed. Read More

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Cement arthrodesis of the knee using combined intramedullary nail, plate and screws after wide excision in huge chondromyxoid fibroma of proximal tibia, a case report.

Int J Surg Case Rep 2022 Apr 12;93:106940. Epub 2022 Mar 12.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Electronic address:

Introduction And Importance: Chondromyxoid fibroma is a rare benign cartilaginous neoplasm, a mixture of benign cartilage and fibrous and myxoid tissue. It usually affects young people, commonly in the second and third decades of life with male being predominant. Differential diagnosess in chondromyxoid fibroma, are giant cell tumor, bone cyst, enchondroma, osteoblastoma, and low-grade chondrosarcoma. Read More

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How I do it: Surgical Resection of a Recurrent Chondromyxoid Fibroma by Micro-Endoscopic Combination Technique.

Acta Neurochir (Wien) 2022 Jul 21;164(7):1961-1965. Epub 2022 Mar 21.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.

Background: The surgical resection of the tumor spreading into the cavernous sinus (CS) is complicated and challenging.

Method: We report a left recurrent CS chondromyxoid fibroma occupying the clival-petrous apex-parasellar-suprasellar area, which was totally removed by the micro-endo combination technique via the middle cranial fossa extradural approach.

Conclusion: This case demonstrates the value of the micro-endoscopic combination technique for complicated skull base surgery. Read More

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Chondromyxoid Fibroma of the Calcaneus: A Rare Case Report.

Cureus 2022 Feb 6;14(2):e21950. Epub 2022 Feb 6.

Orthopedics and Traumatology, Faculty of Medicine, Yeditepe University, Istanbul, TUR.

Chondromyxoid fibroma (CMF) of the calcaneus is extremely rare. We report a case of CMF of the calcaneus in a 34-year-old female. She had foot pain for one year and had increased pain for the last two months. Read More

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February 2022

Chondromyxoid fibroma of zygomatic bone: A case report.

Ann Med Surg (Lond) 2022 Mar 22;75:103394. Epub 2022 Feb 22.

Department of Oral and Maxillofacial Surgery, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Oujda, Morocco.

Introduction: Chondromyxoid fibroma (CMF) is a rare benign bone tumor that typically affects long bones, only 2% of CMFs involved facial bones or skull, zygomatic localization is extremely rare with only 8 cases reported in literature so far.

Presentation Of Case: We report a case of 88 old years patient with painful swelling in the right zygomatic around 1 year, progressively increasing in volume, Computed tomography (CT) scan showed an osteolytic lesion in the right zygomatic bone with cortical destruction. Surgical management consisted of bone curettage using intra oral approach, the histopahological findings were in favor of the diagnosis of CMF. Read More

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Benign bony tumors of the paranasal sinuses, orbit, and skull base.

Am J Otolaryngol 2022 May-Jun;43(3):103404. Epub 2022 Feb 26.

Weill Cornell Medical College, Department of Otolaryngology - Head and Neck Surgery, 2315 Broadway, 3rd Floor, New York, NY 10024, United States of America. Electronic address:

Benign bony tumors of the skull base and paranasal sinuses are uncommon entities, with an overall higher incidence in males. Benign bony tumors may lead to local expansion with resultant mass effect of potentially critical structures. Some benign bony tumors may undergo malignant transformation. Read More

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Management of Primary Aggressive Tumors of the Knee.

J Knee Surg 2022 May 18;35(6):585-596. Epub 2022 Feb 18.

The Center for Orthopedic Research and Eduction (CORE) Institute, Phoenix, Arizona.

Primary bone sarcomas and aggressive benign bone tumors are relatively rare. It is essential to recognize features that are concerning for these aggressive tumors based on a patient's history, physical exam, and radiographs. Physicians and other health care providers should have a high suspicion for these tumors and promptly refer these patients to orthopaedic oncologists. Read More

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Juxtacortical chondromyxoid fibroma in the small bones: two cases with unusual location and a literature review.

J Pathol Transl Med 2022 May 21;56(3):157-160. Epub 2022 Jan 21.

Department of Orthopedic Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.

Chondromyxoid fibroma is a rare bone tumor of cartilaginous origin, representing less than 1% of all bone tumors. It preferentially arises in the eccentric location of the metaphysis of a long tubular bone. Juxtacortical locations are reported infrequently in the long bones and even more rarely in short tubular bones, with only three cases documented. Read More

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Radiological manifestations of chondromyxoid fibroma in the zygoma: A case report and literature review.

BJR Case Rep 2021 Jul 12;7(4):20210008. Epub 2021 May 12.

Neuroradiology Division, Department of Radiology, University of Texas Medical Branch, Galveston, TX, USA.

Chondromyxoid fibroma (CMF) is a rare benign bone tumor of cartilaginous origin, with an extremely rare craniofacial occurrence. Considering its rarity, craniofacial CMF presents a diagnostic challenge for radiologists. To our knowledge, only seven cases of zygomatic CMF have been described in the literature, only one of which was in the paediatric age group. Read More

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Imaging features of cartilaginous tumors of the head and neck.

J Clin Imaging Sci 2021 4;11:66. Epub 2021 Dec 4.

Department of Radiology, Mayo Clinic Arizona, Phoenix, Arizona, United States.

There is a wide spectrum of head and neck cartilaginous lesions which include both neoplastic and nonneoplastic processes. Cartilaginous tumors of the head and neck are uncommon, posing a diagnostic challenge. Benign cartilaginous tumors that may occur in the head and neck include chondroma, chondroblastoma, chondromyxoid fibroma, osteochondroma, and synovial chondromatosis. Read More

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December 2021

Chondromyxoid Fibroma of the Rib: A Rare Benign Tumor With Potential for Local Recurrence.

Cureus 2021 Oct 31;13(10):e19172. Epub 2021 Oct 31.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, GBR.

Chondromyxoid fibroma (CMF) is a benign cartilaginous tumor that typically occurs in the long bones of young adult males, with the clinical presentation varying from asymptomatic to localized pain, swelling, and movement restriction. We report an unusual presentation of CMF involving a rib, along with a literature review of the management of CMF. Although benign, local recurrence is not uncommon, and malignant transformation has been reported on rare occasions. Read More

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October 2021

Chondromyxoid Fibroma-Like Osteosarcoma in a 13 Years Old Girl: A Report of a New Case.

Clin Pathol 2021 Jan-Dec;14:2632010X211057555. Epub 2021 Nov 18.

Department of Pathology, Maternity and Children's Hospital Ibn Sina University Hospital, Rabat, Morocco.

Osteosarcoma (OS) is the most common primary non hematopoietic malignant tumor of bone with a strict histologic definition: the presence of unequivocal osteoid produced by neoplastic cells. Rare variants displaying low-grade histological features have been described; among which chondromyxoid fibroma-like (CMF-OS) is the rarest. However, despite its bland morphology; CMF-like OS has an aggressive clinical behavior and a poor prognosis. Read More

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November 2021

Craniofacial Chondromyxoid Fibromas: A Systematic Review and Analysis Based on Anatomic Locations.

World Neurosurg 2022 Jun 25;162:21-28. Epub 2021 Oct 25.

Department of Neurosurgery, Mayo Clinic, Phoenix, Arizona, USA; Department of Radiology, Mayo Clinic, Phoenix, Arizona, USA; Department of Otolaryngology, Mayo Clinic, Phoenix, Arizona, USA; Precision Neuro-therapeutics Innovation Lab, Mayo Clinic, Phoenix, Arizona, USA; Neurosurgery Simulation and Innovation Lab, Mayo Clinic, Phoenix, Arizona, USA. Electronic address:

Background: Craniofacial chondromyxoid fibromas (CMFs) are a rare benign tumor of cartilaginous origin. They are commonly misdiagnosed due to the paucity of information on tumor characteristics. We performed a systematic review to characterize CMFs located in different regions of the craniofacial skeleton. Read More

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A Rare Cause of Peripheral Facial Nerve Palsy: Chondromyxoid Fibroma of the Temporal Bone.

J Craniofac Surg 2022 May 14;33(3):e276-e279. Epub 2021 Sep 14.

1st Department of Otorhinolaryngology - Head and Neck Surgery, University of Athens Medical School.

Purpose: To report a rather rare entity of facial palsy due to chondromyxoid fibroma. The authors present a case along with clinico-pathological features, management, treatment options and follow-up.

Methods: The authors present a case of a 29-year-old male who suffered from right facial weakness and numbness for a period of 6-months. Read More

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Utility of P63 in Differentiating Giant Cell Tumor from Other Giant Cell-Containing Lesions.

Turk Patoloji Derg 2022 ;38(1):9-15

Department of Pathology, Nizam's Institute of Medical Sciences, HYDERABAD, INDIA.

Objective: To assess P63 expression in giant cell-containing lesions of the bone (GCLB) and to determine its utility in differentiating giant cell tumor of the bone (GCTB) from other GCLBs.

Material And Method: Cases diagnosed as GCLB on histopathology were included in the study. P63 immunohistochemistry was performed in all the cases. Read More

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[Retrofacial approach to remove a rare chondromyxoid fibroma of the infralabyrinthine space].

Vestn Otorinolaringol 2021 ;86(4):106-110

The National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia, Moscow, Russia.

A very rare case of 46-yaer-old woman with chondromyxoid fibroma (CMF) of infralabyrinthine area of temporal bone was described in this article. The only manifestation of this disease was a severe temporary pain in the postauricular area with irradiation in the occipital bone and headache during the last 3 months. A detail description of the CT scan and MRI data was presented. Read More

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September 2021

Case report of a female child with right nasal chondromyxoid fibroma.

J Pak Med Assoc 2021 Jul;71(7):1897-1899

Department of Histopathology, Dow University of Health Sciences, Karachi, Pakistan.

Chondromyxoid fibroma is a rare tumour, representing <1% of all primary bone neoplasm. We report the case of a four-year-old female child with a one-year history of nasal obstruction and facial swelling. A large enhanced lesion with amorphous densities spreading into the right cribriform plate and floor of sphenoid sinus, laterally into the right lamina papyracea, inferolaterally into the medial wall of maxillary sinus, posteriorly into the nasopharynx and superior aspect of oropharynx was observed on CT scan. Read More

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Chondromyxoid fibroma affecting the maxilla in a 1-year-old child: Immunohistochemical analysis and literature review.

Oral Oncol 2022 01 24;124:105467. Epub 2021 Jul 24.

Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Chondromyxoid fibroma (CMF) is a benign chondroid/myxoid matrix-producing tumor that often develops in the long bones of young adults. CMF is rarely reported in the craniofacial skeleton, with most cases presenting with bone erosion or destruction, which may lead to a misdiagnosis. To date, approximately 129 cases of CMF in the craniofacial region have been reported, with only three cases in patients aged less than 1 year. Read More

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January 2022

A Case Report of Chondromyxoid Fibroma of the Neck of Femur, Intracapsular Location.

J Orthop Case Rep 2021 ;11(1):79-81

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Chondromyxoid fibroma (CMF) is an uncommon benign tumor accounts for <2% of all benign and <1% all bone tumors. It is a cartilage tumor with myxoid and fibrous elements. Because of rarity and resemblance with other benign and malignant tumor, diagnosis of this tumor always remains challenging. Read More

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January 2021

Primary Orbital Chondromyxoid Fibroma: A Cause of Monosymptomatic Periocular Pain.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):193-197. Epub 2021 Apr 12.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Chondromyxoid fibroma (CMF) is a very rare entity, accounting for <1% of all bone tumours. So far, only 4 cases have been reported with the orbit as primary location. Here, we present a case of orbital CMF with periocular pain as the presenting symptom and as the only symptom when the tumour recurred after surgery. Read More

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Cytopathology of chondromyxoid fibroma: a case series and review of the literature.

J Am Soc Cytopathol 2021 Jul-Aug;10(4):366-381. Epub 2021 Apr 7.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Introduction: Chondromyxoid fibroma is a rare bone tumor characterized by immature myxoid mesenchymal tissue showing early primitive cartilaginous differentiation. There have been limited case reports describing the cytologic features of chondromyxoid fibroma. Herein, we reported cytologic features of chondromyxoid fibroma on fine-needle aspiration (FNA). Read More

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January 2022

H3.3 K36M Mutation as a Clinical Diagnosis Method of Suspected Chondroblastoma Cases.

Orthop Surg 2021 Apr 23;13(2):616-622. Epub 2021 Feb 23.

Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Whether H3.3 K36M mutation (H3K36M) could be an approach if the diagnosis of chondroblastoma (CB) patients was indistinct and it was suspected to be unclear clinically.

Methods: We reviewed and compared our clinical experiences of CB cases and some suspected cases, which were not diagnosed distinctly, between 2013 to 2019. Read More

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Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital.

Acta Cytol 2021 12;65(1):75-87. Epub 2020 Nov 12.

Department of Orthopaedics, Nizams Institute of Medical Sciences, Hyderabad, India.

Aim: The aim is to study the utility of fine-needle aspiration cytology (FNAC) in preoperative diagnosis of bone lesions in correlation with radiological and histopathological findings and to determine the spectrum and morphological features of various bone lesions on FNAC.

Materials And Methods: A total of 275 cases of bone lesions were studied by FNAC over a period of 3 years. 196 procedures were performed by pathologists, and 107 procedures were guided. Read More

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January 2021

Chondromyxoid fibroma of the nasal cavity - A rare tumor at an unusual site.

Indian J Pathol Microbiol 2020 Oct-Dec;63(4):656-657

Department of ENT, Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

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Sclerosing epithelioid fibrosarcoma of bone: morphological, immunophenotypical, and molecular findings of 9 cases.

Virchows Arch 2021 Apr 21;478(4):767-777. Epub 2020 Oct 21.

Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.

Primary sclerosing epithelioid fibrosarcoma (SEF) of bone is a rare and scarcely reported neoplasm. We document clinicopathological and molecular features of 9 additional cases. Five males and 4 females had a mean age of 39 years (14-71 years). Read More

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H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors.

Histol Histopathol 2021 Jan 4;36(1):61-68. Epub 2020 Sep 4.

Department of Pathology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, China.

H3F3A mutations and the expression of glycine 34 to tryptophan (G34W) mutants in giant cell tumors of bone (GCTBs) and other bone tumors were detected to compare H3F3A mutation types and the expression of G34W-mutant protein in order to provide a theoretical basis for using H3F3A mutations as a diagnostic and differential-diagnostic tool for GCTBs. A total of 366 bone tumor cases were investigated. The cases involved 215 men and 151 women, whose median age was 29 years (3-84). Read More

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January 2021