2,434 results match your criteria Chondrocalcinosis


Calcium pyrophosphate deposition disease: The role of imaging in their detection and in differential diagnosis of crystal arthropathies.

Radiol Case Rep 2020 Oct 4;15(10):1773-1776. Epub 2020 Aug 4.

Motor Science and Wellness Department, University of Naples "Parthenope", Naples, Italy.

Calcium pyrophosphate deposition disease is characterized by the deposition of pyrophosphate crystals in various joint structures. Calcium pyrophosphate deposition disease can be linked to underlying metabolic disorders such as hemochromatosis, hyperparathyroidism, hypophosphatemia, hypomagnesaemia, and hypothyroidism, all of which increase the risk of calcium pyrophosphate deposition. We present the case of a 55-year-old male who underwent diagnostic examination for the onset of recurrent joint pain in the right knee. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403887PMC
October 2020

Answer to Checa « Coexistence of gout and chondrocalcinosis instead? », Joint Bone Spine 2020. DOI:10.1016/j.jbspin.2020.07.007.

Joint Bone Spine 2020 Aug 6. Epub 2020 Aug 6.

Service de rhumatologie, Hôpital Lariboisière, Centre Viggo Petersen, 2, rue Ambroise Paré, 75010 Paris, France.

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http://dx.doi.org/10.1016/j.jbspin.2020.07.010DOI Listing

Tophaceous pseudogout in a 12-year-old dog, with a review of applicable laboratory tests.

J Vet Diagn Invest 2020 Aug 6:1040638720945307. Epub 2020 Aug 6.

Joint Pathology Center, Silver Spring, MD.

Pseudogout, also known as calcium pyrophosphate dihydrate (CPPD) deposition disease or chondrocalcinosis, is caused by crystalline deposits of CPPD within the extracellular matrix of articular hyaline cartilage and fibrocartilage, and within articular and periarticular connective tissue. Using a variety of laboratory techniques, we diagnosed pseudogout in the right hindlimb digit V of a 12-y-old Standard Poodle. Histologically, the joint, bone, tendon, and dermis were expanded and effaced by masses of mineralized, rhomboid crystals surrounded by macrophages, multinucleate giant cells, fibrous connective tissue, and chondroid and osseous matrix. Read More

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http://dx.doi.org/10.1177/1040638720945307DOI Listing

Bone and joint complications in patients with hereditary hemochromatosis: a cross-sectional study of 93 patients.

Ther Adv Musculoskelet Dis 2020 16;12:1759720X20939405. Epub 2020 Jul 16.

Service de rhumatologie, Hôpital Roger Salengro, Rue Emile Laine, CHRU, 59037 Lille cedex, France.

Background: The aim of this study was to determine the frequency and characteristics of bone and joint complications, specifically bone fragility, joint replacement surgery, and arthropathy, in hereditary hemochromatosis (HH) and related factors.

Methods: This study was a cross-sectional observational study of 93 patients with HH. Radiographs of the hands, wrists, knees, and ankles were scored for joint space narrowing, erosions and cysts, osteophytes, and chondrocalcinosis. Read More

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http://dx.doi.org/10.1177/1759720X20939405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366396PMC

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.

Ann Rheum Dis 2020 Jul 22. Epub 2020 Jul 22.

Universite de Paris, Paris, France

Objective: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages goes along with inflammatory responses dependently on stimuli and tissue environment, we aimed to decipher the role of glycolysis and oxidative phosphorylation in the IL-1β-induced microcrystal response.

Methods: Briefly, an in vitro study (metabolomics and real-time extracellular flux analysis) on MSU and CPP crystal-stimulated macrophages was performed to demonstrate the metabolic phenotype of macrophages. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217342DOI Listing

Cartilage calcification is associated with histological degeneration of the knee joint: a highly prevalent, age-independent systemic process.

Osteoarthritis Cartilage 2020 Jul 16. Epub 2020 Jul 16.

Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Germany. Electronic address:

Objectives: To investigate if cartilage calcification (CC) is a systemic process, the purpose of this study was to determine the prevalence and the amount of meniscal/hyaline CC of the knee joint in the general population by high-resolution imaging (DCR) and to evaluate the association between CC with cartilage degeneration and age.

Methods: Cross-sectional DCR-study of 180 knee joints of 90 donors (42 female/48 male, mean age 62.3y). Read More

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http://dx.doi.org/10.1016/j.joca.2020.04.020DOI Listing

Strategies for the assessment of competences during rheumatology training across Europe: results of a qualitative study.

RMD Open 2020 07;6(2)

EULAR, Zurich, Switzerland.

Objectives: To gain insight into current methods and practices for the assessment of competences during rheumatology training, and to explore the underlying priorities and rationales for competence assessment.

Methods: We used a qualitative approach through online focus groups (FGs) of rheumatology trainers and trainees, separately. The study included five countries-Denmark, the Netherlands, Slovenia, Spain and the United Kingdom. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001183DOI Listing

[Bartter-Gitelman syndromes].

Nephrol Ther 2020 Jul 1;16(4):233-243. Epub 2020 Jul 1.

Département de génétique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Centre de Référence de maladies rénales rares de l'enfant et de l'adulte (MARHEA), Paris, France.

Bartter-Gitelman syndromes are rare inherited autosomal recessive salt-losing tubulopathies characterized by severe and chronic hypokalemia associated with metabolic alkalosis and secondary hyperaldosteronism. Bartter syndrome results from a furosemide-like defect in sodium reabsorption in the Henle's loop leading to hypercalciuria and defect in urinary concentration capacity. The antenatal Bartter syndrome is defined by polyhydramnios and an infantile polyuria with severe dehydration whereas classic Bartter syndrome appears during childhood or adulthood. Read More

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http://dx.doi.org/10.1016/j.nephro.2020.06.001DOI Listing

[Inflammatory Muscle Pain: Polymyalgia Rheumatica with or without Large Vessel Vasculitis].

Dtsch Med Wochenschr 2020 Jul 2;145(13):895-902. Epub 2020 Jul 2.

Polymyalgia rheumatica (PMR) is characterized by rapidly evolving shoulder and pelvic girdle pain with fatigue, weight loss, night sweats and elevated CRP and ESR. Giant cell arteritis (GCA) can occur in PMR and vice versa. Headache and scalp tenderness are typical for GCA. Read More

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http://dx.doi.org/10.1055/a-1074-7685DOI Listing

Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis.

RMD Open 2020 06;6(2)

Rheumatology, Leiden University Medical Center, Leiden, Netherlands.

Objectives: Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA.

Methods: In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical, radiographic and laboratory findings were associated with hand OA using logistic regression analyses. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001265DOI Listing

[Choroidal calcification associated to chondrocalcinosis].

Rev Med Inst Mex Seguro Soc 2019 09 2;57(2):324-328. Epub 2019 Sep 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oftalmología, Servicio de Oftalmología. Ciudad de México, México.

Introduction: Chondrocalcinosis is a common joint condition in people over 50, characterized by the deposition of calcium pyrophosphate crystals that causes calcification in cartilage structures. Although its prevalence in the general population is 5%, sclerochoroidal calcifications are a rare finding in this pathology.

Objective: Describe the case of a 60-year-old man with choroidal calcification in the left eye, associated with radiological findings of chondrocalcinosis, whose metabolic report showed parameters compatible with hyperparathyroidism. Read More

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September 2019

Prevalence of chondrocalcinosis in the temporomandibular joint in patients with chondrocalcinosis of the knee or wrist.

Dentomaxillofac Radiol 2020 Jun 18:20190450. Epub 2020 Jun 18.

Department of Radiology, Universitair Ziekenhuis Brussel, Brussel, Belgium.

Objective: The aim of this study was to investigate the prevalence of TMJ chondrocalcinosis on head CT scans in patients with chondrocalcinosis of the knee or wrist.

Methods And Materials: 227 patients with radiological evidence of calcifications on knee or wrist radiographs had a head CT scan obtained for unrelated purposes. CT scans were retrospectively reviewed for the presence of temporomandibular crystal deposition. Read More

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http://dx.doi.org/10.1259/dmfr.20190450DOI Listing

Sonographic assessment of calcium pyrophosphate deposition disease at wrist. A focus on the dorsal scapho-lunate ligament.

Joint Bone Spine 2020 May 11. Epub 2020 May 11.

Polytechnic University of Marche, Department of Clinical and Molecular Sciences, Rheumatology Unit, "Carlo Urbani" Hospital, Via Aldo Moro 25, Jesi 60035, Italy.

Objectives: To investigate the diagnostic accuracy of ultrasound and conventional radiography in the evaluation of calcium pyrophosphate crystal deposits at wrist level.

Methods: Consecutive patients with a "definite" diagnosis of calcium pyrophosphate deposition disease and disease-controls were prospectively included in this cross-sectional single-centre study. Scapho-lunate ligament, triangular fibrocartilage complex, and volar recess of the radio-lunate joint were explored using ultrasound, conventional radiography and computed tomography. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.04.012DOI Listing
May 2020
2.901 Impact Factor

BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a.

Ann Rheum Dis 2020 07 5;79(7):975-984. Epub 2020 May 5.

Division of Mol Medicine of Musculoskeletal Tissue, University Munster, Munster, Germany.

Objective: Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common phenomenon during osteoarthritis (OA). It is directly linked to the severity of the disease and known to be associated to hypertrophic differentiation of chondrocytes. One morphogen regulating hypertrophic chondrocyte differentiation is Wnt3a. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-216648DOI Listing

Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca channel internalization in mesenchymal stem cells.

Bone Res 2020 26;8:19. Epub 2020 Apr 26.

1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032 Shaanxi China.

The loss-of-function mutations in the ALPL result in hypophosphatasia (HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain, chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Read More

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http://dx.doi.org/10.1038/s41413-020-0090-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183511PMC

Clinical characteristics of familial hypocalciuric hypercalcaemia type 1: A multicentre study of 77 adult patients.

Clin Endocrinol (Oxf) 2020 Apr 29. Epub 2020 Apr 29.

Department of Endocrinology, Larrey Hospital, CardioMet Institute, University Hospital Centre of Toulouse, Toulouse, France.

Objective: Familial hypocalciuric hypercalcaemia type 1 (FHH1), related to heterozygous loss-of-function mutations of the calcium-sensing receptor gene, is the main differential diagnosis for primary hyperparathyroidism. The aim of our study was to describe clinical characteristics of adult patients living in France with a genetically confirmed FHH1.

Design And Patients: This observational, retrospective, multicentre study included 77 adults, followed up in 32 clinical departments in France, with a genetic FHH1 diagnosis between 2001 and 2012. Read More

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http://dx.doi.org/10.1111/cen.14211DOI Listing

Cartilage icing and chondrocalcinosis on knee radiographs in the differentiation between gout and calcium pyrophosphate deposition.

PLoS One 2020 16;15(4):e0231508. Epub 2020 Apr 16.

Department of Rheumatology, University of Rochester, Rochester, New York, United States of America.

Objective: To determine if findings of "cartilage icing" and chondrocalcinosis on knee radiography can differentiate between gout and calcium pyrophosphate deposition (CPPD).

Methods: IRB-approval was obtained and informed consent was waived for this retrospective study. Electronic medical records from over 2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231508PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162505PMC

Gitelman syndrome associated with chondrocalcinosis and severe neuropathy: a novel heterozygous mutation in SLC12A3 gene.

Reumatismo 2020 Apr 10;72(1):67-70. Epub 2020 Apr 10.

Unit of Rheumatology, Università di Modena e Reggio Emilia, Modena.

Gitelman syndrome (GS) is an inherited salt-wasting tubulopathy characterized by hypocalciuria, hypokalemia, hypomagnesemia and metabolic alkalosis, due to inactivating mutations in the SLC12A3 gene. Symptoms may be systemic, neurological, cardiovascular, ophthalmological or musculoskeletal. We describe a 70 year-old patient affected by recurrent arthralgias, hypoesthesia and hyposthenia in all 4 limbs and severe hypokalemia, complicated by atrial flutter. Read More

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http://dx.doi.org/10.4081/reumatismo.2020.1255DOI Listing

Apolipoprotein C1 in synovial fluid discriminates septic arthritis from rheumatoid arthritis but not from pseudogout.

Clin Rheumatol 2020 07 12;39(7):2239-2241. Epub 2020 Apr 12.

GREPI University Grenoble-Alpes (UGA) EA74 08, Grenoble, France.

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http://dx.doi.org/10.1007/s10067-019-04912-8DOI Listing

Tophaceous pseudogout of the temporomandibular joint with erosion into the middle cranial fossa.

Int J Oral Maxillofac Surg 2020 Apr 8. Epub 2020 Apr 8.

Maxillofacial Unit, Liverpool Head and Neck Centre, Aintree University Hospital, Liverpool, UK.

This report presents a case of extensive tophaceous pseudogout involving the temporomandibular joint (TMJ), causing erosion into the middle cranial fossa. Pseudogout is a benign metabolic arthropathy caused by calcium pyrophosphate dihydrate crystal deposition within joints and peri-articular tissue. Pseudogout more frequently occurs in large joints such as the knee, wrist, symphysis pubis, and shoulder. Read More

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http://dx.doi.org/10.1016/j.ijom.2020.03.011DOI Listing

Articular manifestations in patients with inflammatory bowel disease treated with vedolizumab.

Rheumatology (Oxford) 2020 Apr 7. Epub 2020 Apr 7.

Department of Rheumatology, INSERM UMR1184, Université Paris-Saclay, Le Kremlin Bicêtre, France.

Objective: Vedolizumab (VDZ) has been incriminated in the occurrence of articular manifestations in patients with inflammatory bowel diseases (IBDs). The aim of this study was to describe musculoskeletal manifestations occurring in IBD patients treated by VDZ and to identify risk factors.

Methods: In this retrospective monocentric study, we included all consecutive patients treated by VDZ for IBD in our hospital. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa107DOI Listing

Idiopathic brain calcification in a patient with hereditary hemochromatosis.

BMC Neurol 2020 Mar 30;20(1):113. Epub 2020 Mar 30.

Internal Medicine Unit and Centre for Hemochromatosis and Heredometabolic Liver Diseases, EuroBloodNet Referral Center for Iron Disorders, Policlinico, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.

Background: Detection of brain-MRI T2/T2* gradient echo images (T2*GRE)-hypointensity can be compatible with iron accumulation and leads to a differential diagnosis work-up including neurodegeneration with brain iron accumulation (NBIA) and Wilson Disease. Idiopathic or secondary brain calcification can be also associated with neurological involvement and brain-MRI T2/T2*GRE-hypointensity. Hereditary hemochromatosis (HH), characterized by systemic iron loading, usually does not involve the CNS, and only sporadic cases of neurological abnormalities or brain-MRI T2/T2*GRE-hypointensity have been reported. Read More

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http://dx.doi.org/10.1186/s12883-020-01689-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106592PMC

Tocilizumab in symptomatic calcium pyrophosphate deposition disease: a pilot study.

Ann Rheum Dis 2020 Aug 25;79(8):1126-1128. Epub 2020 Mar 25.

Service de Rhumatologie, Hopital Lariboisiere, AP-HP, Paris, Île-de-France, France.

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http://dx.doi.org/10.1136/annrheumdis-2020-217188DOI Listing

Reliability of a new scoring system for intraarticular mineralization of the knee: Boston University Calcium Knee Score (BUCKS).

Osteoarthritis Cartilage 2020 Jun 12;28(6):802-810. Epub 2020 Mar 12.

Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, USA.

Background: The role of intra-articular mineralization in osteoarthritis (OA) is unclear. Its understanding may potentially advance our knowledge of knee OA pathogenesis. We describe and assess the reliability of a novel computed tomography (CT) scoring system, the Boston University Calcium Knee Score (BUCKS) for evaluating intra-articular mineralization. Read More

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http://dx.doi.org/10.1016/j.joca.2020.03.003DOI Listing

The need for computed tomography imaging to differentiate the crowned dens syndrome from vertebral osteomyelitis.

Scand J Rheumatol 2020 May 10;49(3):249-250. Epub 2020 Mar 10.

Department of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1080/03009742.2020.1719542DOI Listing

Treatment of hypophosphatasia.

Wien Med Wochenschr 2020 Apr 18;170(5-6):112-115. Epub 2020 Feb 18.

St. Vincent Hospital-2nd Medical Department, The VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, Vienna, Austria.

Hypophosphatasia (HPP) is a rare disorder with perinatal, infantile, childhood, and adult presentations. Severe forms are autosomal recessive with an early onset, whereas milder forms have a later onset. The underlying cause of the disease is a mutation based on a genetic disorder of the tissue non-specific alkaline phosphatase (TNSALP) gene, leading on the one hand to decreased activity of the TNSALP enzyme, and on the other hand to accumulation of TNSALP substrates. Read More

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http://dx.doi.org/10.1007/s10354-020-00736-3DOI Listing

Association between serum zinc and copper concentrations and copper/zinc ratio with the prevalence of knee chondrocalcinosis: a cross-sectional study.

BMC Musculoskelet Disord 2020 Feb 12;21(1):97. Epub 2020 Feb 12.

Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, 410008, Hunan Province, China.

Background: Patients with chondrocalcinosis may suffer from a series of symptoms resembling acute gouty arthritis or septic arthritis, but the aetiology and pathogenesis of chondrocalcinosis have not been fully elucidated yet. This study was aimed to assess serum zinc and copper concentrations, as well as the ratio of serum copper to zinc concentrations (Cu/Zn ratio), in relation to the prevalence of knee chondrocalcinosis.

Methods: Data included in this analysis were retrieved from a large population-based cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12891-020-3121-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017625PMC
February 2020

X-ray Phase Contrast osteo-articular imaging: a pilot study on cadaveric human hands.

Sci Rep 2020 02 5;10(1):1911. Epub 2020 Feb 5.

Inserm UA7 Strobe, Université Grenoble Alpes, Grenoble, 38000, France.

X-ray Phase Contrast Imaging (PCI) is an emerging modality whose availability in clinics for mammography and lung imaging is expected to materialize within the coming years. In this study, we evaluate the PCI Computed Tomography (PCI-CT) performances with respect to current conventional imaging modalities in the context of osteo-articular disorders diagnosis. X-ray PCI-CT was performed on 3 cadaveric human hands and wrists using a synchrotron beam. Read More

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http://dx.doi.org/10.1038/s41598-020-58168-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002527PMC
February 2020

Bilateral hamstring origin calcification: rare presentation of Gitelman syndrome.

BMJ Case Rep 2020 Jan 7;13(1). Epub 2020 Jan 7.

Trauma and Orthopaedics, St Helens and Knowsley NHS Trust, Prescot, Merseyside, UK.

This case report is the first case to our knowledge of intratendinous or peritendinous calcification reported in Gitelman syndrome (GS) patients. GS represents the clinical manifestations of inactivation of the genes encoding the thiazide-sensitive sodium chloride cotransporter and the genes encoding the magnesium transporters in the distal convoluted tubule. Hence, the biochemical findings resemble those with thiazide diuretics such as hypokalaemia, hypomagnesaemia, hypocalciuria, metabolic alkalosis and low normal blood pressure. Read More

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http://dx.doi.org/10.1136/bcr-2018-227992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954790PMC
January 2020

Classifying Pseudogout using Machine Learning Approaches with Electronic Health Record Data.

Arthritis Care Res (Hoboken) 2020 Jan 7. Epub 2020 Jan 7.

Division of Rheumatology, Brigham and Women's Hospital, Boston, USA.

Objective: Identifying pseudogout in large datasets is difficult due to its episodic nature and lack of billing codes specific to this acute subtype of calcium pyrophosphate (CPP) deposition disease. We evaluated a novel machine learning approach for classifying pseudogout using electronic health record (EHR) data.

Methods: We created an EHR data mart of patients with ≥1 relevant billing code or ≥2 natural language processing (NLP) mentions of pseudogout or chondrocalcinosis, 1991-2017. Read More

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http://dx.doi.org/10.1002/acr.24132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338229PMC
January 2020
4.713 Impact Factor

Degenerative rotator cuff tear, repair or not repair? A review of current evidence.

Ann R Coll Surg Engl 2020 Apr 3;102(4):248-255. Epub 2020 Jan 3.

Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Introduction: We review the literature and highlight the important factors to consider when counselling patients with non-traumatic rotator cuff tears on which route to take. Factors include the clinical outcomes of surgical and non-surgical routes, tendon healing rates with surgery (radiological outcome) and natural history of the tears if treated non-operatively.

Methods: A PRISMA-compliant search was carried out, including the online databases PubMed and Embase™ from 1960 to the end of June 2018. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099167PMC

Progresses in the imaging of calcium pyrophosphate crystal disease.

Curr Opin Rheumatol 2020 Mar;32(2):140-145

Sección de Reumatología, Hospital General Universitario de Alicante-ISABIAL.

Purpose Of Review: Calcium pyrophosphate crystal disease (CPPD) may be considered a neglected disorder, common in clinics and wards, but not receiving enough attention since the time it was recognized as a disease entity. This review aims to highlight the advances occurred in recent years in terms of imaging of CPPD, and their potential aid in diagnosing CPPD.

Recent Findings: The main advances in CPPD imaging have occurred with ultrasound and computed tomography. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000690DOI Listing

Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.

Arthritis Res Ther 2019 12 17;21(1):291. Epub 2019 Dec 17.

Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Lund and Skåne University Hospital, Lund, Sweden.

Objective: To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden.

Methods: All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998-2014 were identified. Read More

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http://dx.doi.org/10.1186/s13075-019-2077-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918617PMC
December 2019

Treatment of calcium pyrophosphate deposition in the temporomandibular joint with resection and simultaneous reconstruction using a custom joint prosthesis.

Oral Maxillofac Surg 2020 Jun 16;24(2):235-238. Epub 2019 Dec 16.

Department of Oral & Maxillofacial Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.

Purpose: The authors present a rare case of calcium pyrophosphate deposition disease (CPPD) in the temporomandibular joint (TMJ), successfully treated with complete resection and immediate reconstruction using a custom-made prosthesis. This one-stage approach has prevented the patient from requiring two surgeries and has proven effective in the management of the condition.

Methods: Our patient, a 56-year-old male, presented with left TMJ pain and trismus. Read More

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http://dx.doi.org/10.1007/s10006-019-00825-7DOI Listing

Chondrocalcinosis of the Knee and the Risk of Osteoarthritis Progression: Data From the Knee and Hip Osteoarthritis Long-term Assessment Cohort.

Arthritis Rheumatol 2020 05 3;72(5):726-732. Epub 2020 Apr 3.

Lariboisière Hospital, AP-HP, INSERM U1132, UFR de Médecine, and Paris Diderot University, Paris, France.

Objective: To assess the impact of knee chondrocalcinosis (CC) on the 5-year risk of joint replacement and disease progression in patients with knee osteoarthritis (OA).

Methods: Patients with symptomatic knee OA without previous total joint (knee or hip) replacement (TJR) were recruited from the Knee and Hip Osteoarthritis Long-term Assessment cohort. Cox proportional hazards regression and generalized estimating equation models were used to compare the time from inclusion or OA diagnosis to total knee replacement (TKR) or TJR between patients with and those without knee CC at inclusion. Read More

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http://dx.doi.org/10.1002/art.41186DOI Listing

Dual-energy CT in the differentiation of crystal depositions of the wrist: does it have added value?

Skeletal Radiol 2020 May 4;49(5):707-713. Epub 2019 Dec 4.

Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: To evaluate the ability of dual-energy computed tomography (DECT) to improve diagnostic discrimination between gout and other crystal arthropathies such as calcium pyrophosphate deposition disease (CPPD) of the wrist in a clinical patient population.

Materials And Methods: This retrospective case-control study included 29 patients with either gout (case group; n = 9) or CPPD (control group; n = 20) who underwent DECT of the wrist for clinically suspected crystal arthropathy. Color-coded urate and enhanced calcium as well as virtual 120 kVe blended images were reconstructed from the DECT datasets. Read More

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http://dx.doi.org/10.1007/s00256-019-03343-5DOI Listing

Pseudogout or pseudolymphoma? Calcium pyrophosphate deposition disease of the cervical spine: a rare presentation and literature review.

BMJ Case Rep 2019 Dec 2;12(12). Epub 2019 Dec 2.

Department of Rheumatology, Royal Free London NHS Foundation Trust, London, UK.

Calcium pyrophosphate deposition (CPPD) disease is a crystal arthropathy primarily affecting peripheral joints, most commonly the wrist and the knees. However, CPPD in the cervical spine is a rare entity. This report describes a case of CPPD of the cervical spine which presents with symptoms of neck pain and brachalgia. Read More

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http://dx.doi.org/10.1136/bcr-2019-231508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001700PMC
December 2019

Pseudogout Diagnosed By Point-of-care Ultrasound.

Clin Pract Cases Emerg Med 2019 Nov 30;3(4):425-427. Epub 2019 Sep 30.

Geisinger Medical Center, Department of Emergency Medicine, Danville, Pennsylvania.

A 71-year-old male presented to the emergency department (ED) for worsening right knee pain for the prior 3-4 weeks. Point-of-care ultrasound (POCUS) of the right knee showed a pseudo-double contour sign. Subsequent ultrasound-guided arthrocentesis of the knee joint was performed, and fluid studies showed the presence of calcium pyrophosphate crystals, which was consistent with pseudogout. Read More

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http://dx.doi.org/10.5811/cpcem.2019.7.43244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861017PMC
November 2019

Calcium pyrophosphate dihydrate deposition disease: a forgotten common arthritis in the elderly.

BMJ Case Rep 2019 Nov 21;12(11). Epub 2019 Nov 21.

Geriatric Unit, Internal Medicine, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia.

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http://dx.doi.org/10.1136/bcr-2019-232828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887393PMC
November 2019

Association of 4-basepair G-to-A transition in the 5'-untranslated region of ANKH gene with selected patients of primary knee osteoarthritis: A cross sectional study.

J Family Med Prim Care 2019 Sep 30;8(9):2937-2941. Epub 2019 Sep 30.

Department of Rheumatology, Post Doctoral Fellow Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India.

Method: A cohort study was carried out for a year to evaluate the presence of G-to-A transition in 5'-untranslated region of ankylosis human () gene in Indian Khatri patients (closely resembling Europeans of primary knee osteoarthritis (OA), residing in Lucknow, India.

Results: In the total participants, 25 were Khatri primary knee OA patients (cases) residing in Lucknow and 101 were random blood donors' samples (controls) collected from a blood bank. All were studied for the abovementioned mutation using real-time polymerase chain reaction (RT-PCR). Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_471_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820404PMC
September 2019

Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence.

J Rheumatol 2020 Aug 1;47(8):1261-1266. Epub 2019 Nov 1.

From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Objective: Little is known about acute calcium pyrophosphate (CPP) crystal arthritis flare rates and risk factors for recurrence. We characterized flares and determined the rate and predictors of acute CPP crystal arthritis flares in an academic medical center cohort.

Methods: We performed a retrospective cohort study among a random sample of patients with acute CPP crystal arthritis identified in the Partners HealthCare electronic medical record, 1991-2017. Read More

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http://dx.doi.org/10.3899/jrheum.190778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192778PMC
August 2020
1 Read
3.187 Impact Factor

Effects of arthroscopic vs. mini-open rotator cuff repair on function, pain & range of motion. A systematic review and meta-analysis.

PLoS One 2019 31;14(10):e0222953. Epub 2019 Oct 31.

Collaborative Program in Musculoskeletal Health Research, Bone and Joint Institute, Western University, London, ON Canada.

Objective: To assess the effectiveness of arthroscopic versus mini-open rotator cuff repair on function, pain and range of motion at 3-, 6- and 12-month follow ups.

Design: Systematic review and meta-analysis of randomized controlled trials.

Setting: Clinical setting. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822715PMC
March 2020
3.234 Impact Factor

Chondrocalcinosis is associated with increased knee joint degeneration over 4 years: data from the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2020 02 17;28(2):201-207. Epub 2019 Oct 17.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

Objective: To determine if presence of calcium-containing crystals (CaC) is associated with increased knee joint degeneration over 4 years and assess if total number of CaCs deposited is a useful measure of disease burden.

Design: Seventy subjects with CaCs in right knees at baseline were selected from the Osteoarthritis Initiative and matched to 70 subjects without evidence of CaCs. T1-weighted gradient-echo sequences were used to confirm presence of CaCs and count the numbers of distinct circumscribed CaCs. Read More

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http://dx.doi.org/10.1016/j.joca.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002267PMC
February 2020
2 Reads

Five-Year Follow-up of Arthroscopic Superior Capsule Reconstruction for Irreparable Rotator Cuff Tears.

J Bone Joint Surg Am 2019 Nov;101(21):1921-1930

Department of Orthopedic Surgery, Osaka Medical College, Takatsuki, Japan.

Background: Arthroscopic superior capsule reconstruction was developed to restore superior stability, muscle balance, and function in the shoulder joint after an irreparable rotator cuff tear. Our objective was to assess the functional and radiographic results of superior capsule reconstruction after 5 years of follow-up.

Methods: Thirty patients who underwent arthroscopic superior capsule reconstruction using fascia lata autograft were enrolled in this study. Read More

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http://dx.doi.org/10.2106/JBJS.19.00135DOI Listing
November 2019
2 Reads

Heterotopic ossification: radiological and pathological review.

Radiol Oncol 2019 09 24;53(3):275-284. Epub 2019 Sep 24.

Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, USA.

Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. Read More

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http://dx.doi.org/10.2478/raon-2019-0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765162PMC
September 2019
1 Read

There is no difference in postoperative pain, function and complications in patients with chondrocalcinosis in the outcome of total knee arthroplasty for end-stage osteoarthritis.

Knee Surg Sports Traumatol Arthrosc 2019 Sep 24. Epub 2019 Sep 24.

Department of Orthopaedic Surgery, Spaarne Gasthuis, Spaarnepoort 1, 2130AT, Hoofddorp, The Netherlands.

Purpose: Chondrocalcinosis is the radiographic appearance of calcium crystals in cartilage and other soft tissue. It is suggested that preoperative chondrocalcinosis predicts a worse outcome after total knee arthroplasty and it is unclear if chondrocalcinosis leads to more postoperative complications. This study aimed to compare function, pain, postoperative complications, postoperative signs of acute arthritis and revision rates between patients with and without chondrocalcinosis undergoing total knee arthroplasty for osteoarthritis. Read More

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http://dx.doi.org/10.1007/s00167-019-05725-7DOI Listing
September 2019
5 Reads

[Chondrocalcinosis: idiopathic or manifestation of rare metabolic diseases?]

Orthopade 2019 Nov;48(11):949-956

Medizinische Klinik 3 - Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Deutschland.

Calcification in hyaline and fibrocartilage is caused by the deposition of calcium pyrophosphate dehydrate, commonly referred to as chondrocalcinosis. Clinically, this can lead to arthritis symptoms similar to a gout attack -"pseudogout". Nonetheless, also chronic or asymptomatic disease courses are possible. Read More

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http://dx.doi.org/10.1007/s00132-019-03805-7DOI Listing
November 2019
7 Reads

Calcium Pyrophosphate Deposition Disease Arthropathy-Related Sciatica.

Arthritis Rheumatol 2019 12 25;71(12):2099. Epub 2019 Oct 25.

University Hospital of St. Etienne, Inserm U1059 and University of Lyon, St. Etienne, France.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/art.41099
Publisher Site
http://dx.doi.org/10.1002/art.41099DOI Listing
December 2019
3 Reads

Reverse total shoulder arthroplasty in the younger patient (≤65 years): a systematic review.

J Shoulder Elbow Surg 2020 Jan 3;29(1):202-209. Epub 2019 Sep 3.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada. Electronic address:

The purpose of this study was to evaluate outcomes of reverse total shoulder arthroplasty (RTSA) in patients aged ≤65 years. MEDLINE, Embase, and PubMed were searched for relevant studies from database inception to September 18, 2018. All studies that evaluated RTSA in patients aged ≤65 years were included. Read More

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http://dx.doi.org/10.1016/j.jse.2019.06.018DOI Listing
January 2020