2,583 results match your criteria Chondrocalcinosis


Editorial Commentary: Rotator Cuff Repairs Fail at an Alarmingly High Rate During Long-Term Follow-Up: Graft Augmentation and Biologics May Improve Future Outcomes.

Arthroscopy 2022 Aug;38(8):2413-2416

Wake Forest University School of Medicine (N.A.T.).

Rotator cuff repairs (RCR) frequently fail to heal, particularly those with advanced fatty infiltration, supraspinatus and infraspinatus atrophy, narrowed acromiohumeral distance, and large-to-massive tear size. Unfortunately, the longer the follow up, the more sobering the statistics, with some reported retear rates ranging up to 94%. Importantly, recent long-term radiographic assessments after primary RCR reveal direct correlations between failure and patient-reported outcomes, functional deterioration, and ultimately, progression of glenohumeral arthritis and/or frank cuff tear arthropathy. Read More

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Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors.

ACS Omega 2022 Aug 19;7(30):26905-26918. Epub 2022 Jul 19.

Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad22060, Pakistan.

Aberrant level of ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 is linked with numerous disorders, for instance, diabetes, cancer, osteoarthritis, chondrocalcinosis, and allergic reactions. These disorders may be cured or minimized by blocking the activity of ENPP1 and ENPP3 isozymes. In this study, arylamide sulphonates were synthesized, characterized, and evaluated for their capability to affect the activity of isozymes ENPP1 and ENPP3. Read More

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Parathyroid Carcinoma All-In-One, a Rare Life-Threatening Case With Multiple Systemic Manifestations: Case Report and Review of the Literature.

Front Endocrinol (Lausanne) 2022 7;13:881225. Epub 2022 Jul 7.

Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico "Gemelli" IRCCS, Rome, Italy.

Parathyroid carcinoma (PC) is an extremely rare disease. Although it may occasionally occur in genetic syndromes, it is more often sporadic. It is usually associated with a consistent secretion of PTH, causing severe hypercalcemia and potentially all clinical conditions due to primary hyperparathyroidism. Read More

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High prevalence of chondrocalcinosis and frequent comorbidity with calcium pyrophosphate deposition disease in patients with seronegative rheumatoid arthritis.

RMD Open 2022 06;8(2)

Ruhr University Bochum, Bochum, Germany

Background: The crystal-induced calcium pyrophosphate deposition disease (CPPD) clinically appearing as pseudogout differs from the mere radiographic finding of chondrocalcinosis (CC) but may cause symptoms resembling rheumatoid arthritis (RA).

Objective: To study the prevalence of CPPD and CC in rheumatic diseases focusing on differences between seropositive and seronegative RA.

Patients And Methods: In a retrospective study design, we analysed records and radiographs of consecutive new patients presenting to our centre between January 2017 and May 2020. Read More

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Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.

Radiol Clin North Am 2022 Jul;60(4):641-656

Department of Radiology, Medical University Innsbruck, Anichstrasse 35 A-6020, Innsbruck, Austria.

Crystal arthropathies are a group of joint disorders due to deposition of crystals in and around joints that lead to joint destruction and soft tissue masses. Clinical presentation is variable and diagnosis might be challenging. In this article the pathophysiology is addressed, the preferred deposition of crystal arthropathies and imaging findings. Read More

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Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis.

Ann Rheum Dis 2022 May 25. Epub 2022 May 25.

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Objectives: Calcium pyrophosphate deposition (CPPD) disease, broadly defined, has been associated with increased risk of cardiovascular (CV) events. We investigated risk of CV events in patients with acute CPP crystal arthritis, the acute manifestation of CPPD.

Methods: Cohort study using Mass General Brigham electronic health record (EHR) data, 1991-2017. Read More

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Recall Bias in Retrospective Assessment of Preoperative American Shoulder and Elbow Surgeons Scores After Reverse Total Shoulder Arthroplasty.

J Am Acad Orthop Surg 2022 Aug 18;30(15):e1051-e1057. Epub 2022 May 18.

From the Department of Orthopaedics and Sports Medicine, University of Cincinnati Medical Center, Cincinnati, OH.

Introduction: Although reverse total shoulder arthroplasty (RTSA) has been shown to be effective for the treatment of cuff tear arthropathy (CTA), the patient's inability to accurately recall their preoperative shoulder condition could skew their perception of the effectiveness of the procedure. Identifying patients who are susceptible to notable recall bias before surgery can help surgeons counsel patients regarding expectations after surgery. The purpose of this study was to evaluate whether patients who undergo RTSA are susceptible to recall bias and, if so, which factors are associated with poor recollection. Read More

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Chondrocalcinosis under Diagnostic Ultrasound in a Recreational Tennis Player.

Am J Phys Med Rehabil 2022 Apr 15. Epub 2022 Apr 15.

H. Ben Taub Dept of Physical Medicine & Rehabilitation, Baylor College of Medicine, Houston, Texas, U.S.A.

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Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization.

Rheumatology (Oxford) 2022 Apr 12. Epub 2022 Apr 12.

Dept. Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden (LUMC), The Netherlands.

Objectives: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.

Methods: OPG-XL was studied by human induced pluripotent stem cells expressing OPG-XL and two isogenic CRISPR/Cas9-corrected controls in cartilage and bone organoids. Osteoclastogenesis was studied with monocytes from OPG-XL carriers and matched healthy controls followed by gene expression characterization. Read More

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Arthroscopic Distal Clavicle Resection for an Acromioclavicular Ganglion Cyst with Cuff Tear Arthropathy: A Case Report.

JBJS Case Connect 2022 04 6;12(2). Epub 2022 Apr 6.

Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.

Case: A 77-year-old man with an acromioclavicular joint ganglion cyst with cuff tear arthropathy had a large mass in the left shoulder. Arthroscopic distal clavicle resection successfully relieved his symptoms without loss of shoulder function by enlargement of the bypass between the cyst and subacromial space through the acromioclavicular joint.

Conclusion: Arthroscopic distal clavicle resection can remove a 1-way check valve in a minimally invasive manner. Read More

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The Ultrasound-guided Anteromedial Joint Line Approach: A Targeted Corticosteroid Injection Technique for Patients With Medial Knee Pain.

Pain Physician 2022 03;25(2):E319-E329

Division of Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Background: Medial knee pain is a common complaint in the adult population. When conservative measures fail, intraarticular knee corticosteroid injections are often offered through the superolateral approach into the suprapatellar recess to provide short-term relief. However, some patients fail to respond and require alternative approaches. Read More

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Acute Calcium Pyrophosphate Crystal Arthritis of the Wrist Elicited by Anti-COVID-19 Vaccination After Carpal Tunnel Release.

Am J Case Rep 2022 Mar 12;23:e934833. Epub 2022 Mar 12.

Plastic and Reconstructive Surgery Unit, Padua University Hospital, Padua, Italy.

BACKGROUND Calcium pyrophosphate dihydrate deposition disease includes a variety of clinical syndromes, including acute calcium pyrophosphate (CPP) crystal arthritis. Most patients with CPP crystal arthritis have a primary/idiopathic form presenting with severe pain, swelling, and stiffness. COVID-19 infection, which originated in China in December 2019, required extraordinary efforts to develop and test new vaccines to halt the pandemic. Read More

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Histone Deacetylase Inhibitors Downregulate Calcium Pyrophosphate Crystal Formation in Human Articular Chondrocytes.

Int J Mol Sci 2022 Feb 26;23(5). Epub 2022 Feb 26.

School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Calcium pyrophosphate (CPP) deposition disease (CPPD) is a form of CPP crystal-induced arthritis. A high concentration of extracellular pyrophosphate (ePPi) in synovial fluid is positively correlated with the formation of CPP crystals, and ePPi can be upregulated by ankylosis human (ANKH) and ectonucleotide pyrophosphatase 1 (ENPP1) and downregulated by tissue non-specific alkaline phosphatase (TNAP). However, there is currently no drug that eliminates CPP crystals. Read More

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February 2022

Outcomes and resource utilization in calcium pyrophosphate deposition disease patients who underwent total knee arthroplasty: a cross-sectional analysis.

Clin Rheumatol 2022 Jun 17;41(6):1817-1824. Epub 2022 Feb 17.

College of Medicine, University of Arizona, 475 N 5th street, Phoenix, AZ, 85031, USA.

This cross-sectional study aims to evaluate the predictors, outcomes, and resource utilization of total knee arthroplasty (TKA) in calcium pyrophosphate deposition disease (CPPD) patients. We used the US National Inpatient Sample database to identify CPPD and non-CPPD who underwent TKA from 2006 to 2014. Data collection included patient demographics and comorbidities. Read More

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Sclerochoroidal calcification associated with chondrocalcinosis: A clinical case.

Ann Med Surg (Lond) 2022 Feb 29;74:103275. Epub 2022 Jan 29.

Medical Resident at Pediatric Ophthalmology Department, Ho^pital 20, Aou^t, 1953, Casablanca, Morocco.

Introduction: Sclerochoroidal calcifications is a rare condition corresponding to senile plaques due to the deposition of calcium and phosphate in the sclera and choroid. It is an elderly patient's pathology. In most cases, it is idiopathic. Read More

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February 2022

Identification of Common Pathogenic Pathways Involved in Hemochromatosis Arthritis and Calcium Pyrophosphate Deposition Disease: a Review.

Curr Rheumatol Rep 2022 02 10;24(2):40-45. Epub 2022 Feb 10.

Research Division, cc-117, Zablocki VA Medical Center, 5000 W. National Ave, Milwaukee, WI, 53295-1000, USA.

Objectives: Arthritis is a common clinical manifestation of hereditary hemochromatosis (HH), and HH is one of a handful of conditions linked to calcium pyrophosphate deposition (CPPD) in joints. The connection between these two types of arthritis has not yet been fully elucidated. In light of new pathogenic pathways recently implicated in CPPD involving bone, we reviewed the literature on the etiology of hemochromatosis arthropathy (HHA) seeking shared pathogenic mechanisms. Read More

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February 2022

Hereditary haemochromatosis presenting to rheumatology clinic as inflammatory arthritis.

BMJ Case Rep 2022 Jan 17;15(1). Epub 2022 Jan 17.

The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK.

Hereditary haemochromatosis (HH) is the most commonly identified genetic disorder in Caucasians. HH has a wide variety of clinical manifestations. As such, the presenting complaint in new diagnoses of HH can be non-specific such as fatigue; however, joint symptoms such as arthralgia are also common. Read More

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January 2022

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases.

Int J Mol Sci 2021 Dec 31;23(1). Epub 2021 Dec 31.

Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Liège, University of Liège, 4000 Liège, Belgium.

An inflamed synovial membrane plays a major role in joint destruction and is characterized by immune cells infiltration and fibroblast proliferation. This proteomic study considers the inflammatory process at the molecular level by analyzing synovial biopsies presenting a histological inflammatory continuum throughout different arthritis joint diseases. Knee synovial biopsies were obtained from osteoarthritis (OA; n = 9), chronic pyrophosphate arthropathy (CPPA; n = 7) or rheumatoid arthritis (RA; n = 8) patients. Read More

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December 2021

Restoration of active internal rotation following reverse shoulder arthroplasty: anterior latissimus dorsi and teres major combined transfer.

J Shoulder Elbow Surg 2022 Jun 27;31(6):1154-1165. Epub 2021 Dec 27.

Department of Mathematics, Dongguk University, Seoul, Republic of Korea.

Background: Reverse shoulder arthroplasty (RSA) for irreparable massive rotator cuff tear (mRCT) and cuff tear arthropathy (CTA) demonstrates satisfactory clinical outcomes. However, many studies have reported no significant improvements in internal and external rotation. To our knowledge, there have been no studies on new attempts to restore active internal rotation following RSA. Read More

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Does correction of reverse shoulder arthroplasty angle improve clinical outcomes in cuff tear arthropathy?

Acta Orthop Traumatol Turc 2021 Dec;55(6):466-472

Department of Orthopedics and Traumatology, Bezmialem Foundation University, İstanbul, Turkey.

Objective: The aim of this study was to investigate the impact of correction of the reverse shoulder arthroplasty (RSA) angle on clinical outcomes in patients with cuff tear arthropathy (CTA).

Methods: This single-center retrospective study was conducted in patients with CTA treated with RSA between 2013 and 2018. A structured questionnaire collecting demographic data, postoperative follow-up time, pre- and postoperative range of motion (ROM), American Shoulder and Elbow Surgeons (ASES) and Constant functional scores as well as scapular notching according to the Sirveaux Classification and RSA angle were evaluated by independent observers. Read More

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December 2021

Clinical Outcomes After Reverse Total Shoulder Arthroplasty in Patients With Primary Glenohumeral Osteoarthritis Compared With Rotator Cuff Tear Arthropathy: Does Preoperative Diagnosis Make a Difference?

J Am Acad Orthop Surg 2022 Feb;30(3):e415-e422

From the New England Baptist Hospital Department of Sports Medicine, Boston, MA (Saini, Pettit, Puzzitiello, Shah, Jawa, and Kirsch), Boston Sports and Shoulder Center, MA (Hart, Jawa, and Kirsch), and New England Shoulder and Elbow Center, MA (Shah).

Introduction: The primary purpose of this study was to evaluate the clinical outcomes of patients who underwent reverse total shoulder arthroplasty performed for primary glenohumeral osteoarthritis (GHOA) with an intact rotator cuff compared with rotator cuff tear arthropathy (CTA).

Methods: This was a retrospective review of prospectively collected data including consecutive patients who underwent primary reverse total shoulder arthroplasty for GHOA or CTA with a minimum of 2-year follow-up. Baseline patient demographics and clinical outcomes including active range of motion, American Shoulder and Elbow Surgeons (ASES) score, Single Assessment Numerical Evaluation, and visual analog scale for pain were collected. Read More

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February 2022

[Management of joint empyema].

Unfallchirurg 2022 Jan 7;125(1):19-25. Epub 2021 Dec 7.

Klinik für Unfallchirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Joint empyema, also known as septic arthritis, is a severe disease associated with considerable morbidity and mortality. Failing to initiate immediate treatment can result in irreversible joint destruction within a short time. The knee joint is most frequently involved, followed by the shoulder and hip joints. Read More

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January 2022

Reverse Shoulder Arthroplasty After Prior Rotator Cuff Repair: A Matched Cohort Analysis.

J Am Acad Orthop Surg 2022 Feb;30(3):e395-e404

From the Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, FL (Marigi, Crowe, and Schoch), Exactech Inc (Tams), Department of Orthopaedics and Rehabilitation (King and Wright), University of Florida, Gainesville, FL, the Department of Orthopedic Surgery, Hopital Ambroise Paré, Boulogne-Billancourt, France (Werthel), and the Department of Orthopaedics, Medical University of South Carolina, Charleston, SC (Friedman and Eichinger).

Introduction: Rotator cuff repair (RCR) is commonly performed before reverse shoulder arthroplasty (RSA) with conflicting evidence on the effect on arthroplasty outcomes. The purpose of this investigation was to evaluate the effect of a prior RCR on the outcomes and complications of primary RSA.

Methods: Between 2007 and 2017, 438 RSAs performed in patients with a prior RCR and 876 case-matched controls were identified from a multicenter database. Read More

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February 2022

Polymyalgia Rheumatica in a Patient with Pseudogout and Dementia.

Am J Case Rep 2021 Nov 23;22:e933926. Epub 2021 Nov 23.

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

BACKGROUND The differential diagnosis of generalized pain includes reactivity associated with bacterial and viral infections, autoimmune rheumatic disease, and orthopedic diseases. Obtaining a detailed medical history and establishing an accurate diagnosis are difficult in elderly patients with dementia. In addition, the differential diagnosis between polymyalgia rheumatica and pseudogout is often difficult. Read More

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November 2021

Review: Outcome measures in calcium pyrophosphate deposition.

Best Pract Res Clin Rheumatol 2021 12 17;35(4):101724. Epub 2021 Nov 17.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

This review highlights outcomes for patients with calcium pyrophosphate deposition (CPPD) reported in prior studies and underscores challenges to assessing outcomes of this condition. Prior clinical studies of interventions for CPPD focused on joint damage and calcification on imaging tests, joint pain, swelling, and inflammatory biomarkers. Qualitative interviews with patients with CPPD and healthcare providers additionally identified flares, overall function, and use of analgesic medications as important outcomes. Read More

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December 2021

Immunologic Contributions Following Rotator Cuff Injury and Development of Cuff Tear Arthropathy.

JBJS Rev 2021 11 10;9(11). Epub 2021 Nov 10.

Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

»: Rotator cuff tear arthropathy (RCTA) describes a pattern of glenohumeral degenerative changes following chronic rotator cuff tears that is characterized by superior humeral head migration, erosion of the greater tuberosity of the humeral head, contouring of the coracoacromial arch to create a socket for the humeral head, and eventual glenohumeral arthritis.

»: Acute and chronic inflammatory changes following rotator cuff tears are thought to contribute to cartilage damage, muscle fibrosis, and fatty infiltration in the glenohumeral joint.

»: In vitro animal studies targeting various inflammatory modulators, including macrophages, insulin-like growth factor-I, and transforming growth factor-beta pathways, provide promising therapeutic targets to improve healing after rotator cuff tears. Read More

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November 2021

Calcium pyrophosphate deposition (CPPD) disease - Treatment options.

Best Pract Res Clin Rheumatol 2021 12 28;35(4):101720. Epub 2021 Oct 28.

Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland; University College Dublin, Ireland. Electronic address:

In contrast to gout, no disease-modifying therapies currently exist that reduce articular crystal deposition of calcium pyrophosphate crystals (CPPs). Treatment is aimed at ameliorating the inflammatory response and reducing the frequency and severity of clinical symptoms due to CPP deposition (CPPD). Despite being one of the most common forms of inflammatory arthritis, CPPD remains under-studied and evidence-based treatment guidelines remain lacking. Read More

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December 2021

Multilevel calcium pyrophosphate dihydrate deposition in cervical ligamentum flavum: clinical characteristics and imaging features.

BMC Musculoskelet Disord 2021 Nov 4;22(1):929. Epub 2021 Nov 4.

Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan, Republic of China.

Background: Involvement in cervical ligamentum flavum is a rare manifestation of the calcium pyrophosphate dihydrate deposition disease. Only few cases of this condition have been reported. We revealed eighteen cases of CPPD in cervical ligamentum flavum that diagnosed at a single medical center. Read More

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November 2021

The role of calcium crystals and their effect on osteoarthritis pathogenesis.

Best Pract Res Clin Rheumatol 2021 12 31;35(4):101722. Epub 2021 Oct 31.

Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany. Electronic address:

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive degeneration of articular cartilage. Due to its high prevalence and limited treatment options, OA has become one of the most disabling diseases in developed countries. In recent years, OA has been recognized as a heterogenic disease with various phenotypes. Read More

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December 2021