2,516 results match your criteria Chondrocalcinosis


Surgical management of MILD hyperparathyroidism.

Eur Arch Otorhinolaryngol 2021 Jul 30. Epub 2021 Jul 30.

ENT Department, Rennes University Medical Center, 35000, Rennes, France.

Introduction: There is no consensus for management of Mild primary hyperparathyroidism (MILD-pHP). Specific management has been suggested by some authors. We have compared the surgical management of the patients with MILD-pHP to those with Classic primary hyperparathyroidism (C-pHP) treated by surgery according to The Fourth International Workshop on pHP. Read More

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The role of Interleukin-1 receptor antagonist as a treatment option in calcium pyrophosphate crystal deposition disease.

Mol Biol Rep 2021 May 1;48(5):4789-4796. Epub 2021 Jun 1.

Rheumatology Clinic "Mario Carrozzo", Department of Medical and Surgical Sciences, University of Foggia, "Policlinico Riuniti" University Hospital, Viale Pinto, 1, 71121, Foggia, Italy.

Calcium Pyrophosphate Crystal Deposition (CPPD) disease is characterized by the deposition of calcium pyrophosphate crystals in the cartilage. In most cases, it can manifest as a subclinical condition named chondrocalcinosis, often revealed by joint x-ray examination. In other cases, deposition can cause flares of arthritis, known as acute CPP crystal arthritis. Read More

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Ultra-high resolution 3D MRI for chondrocalcinosis detection in the knee-a prospective diagnostic accuracy study comparing 7-tesla and 3-tesla MRI with CT.

Eur Radiol 2021 May 28. Epub 2021 May 28.

Department of Radiology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Objectives: To test the diagnostic accuracy of a 3D dual-echo steady-state (DESS) sequence at 7-T MRI regarding the detection of chondral calcific deposits of the knee in comparison to 3-T MRI, using CT as cross-sectional imaging reference standard.

Methods: CT and 7-T MRI (DESS) of knee joints in 42 patients with radiographically known chondrocalcinosis (13 of 42 bilateral) were prospectively acquired for all included patients (n = 55 knee joints). Additionally, 3-T MRI (DESS) was performed for 20 of these 55 knee joints. Read More

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Answer to Cipolletta et al. "Treatment of acute CPP crystal arthritis: What are we missing?". Joint Bone Spine 2021;88:105217.

Joint Bone Spine 2021 May 21;88(5):105223. Epub 2021 May 21.

Department of Rheumatology, Lausanne University Hospital (CHUV), avenue Pierre-Decker 4, 1005 Lausanne, Switzerland.

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Treatment of acute CPP crystal arthritis: What are we missing? Comment on: "Anakinra compared to prednisone in the treatment of acute CPPD crystal arthritis: A randomized controlled double-blinded pilot study" by Dumusc A. et al. Joint Bone Spine. 2020;88:105088.

Joint Bone Spine 2021 May 14;88(5):105217. Epub 2021 May 14.

Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, "Carlo Urbani" Hospital, Via Aldo Moro 25, 60035 Jesi, Ancona, Italy.

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The role of TNFRSF11B in development of osteoarthritic cartilage.

Rheumatology (Oxford) 2021 May 14. Epub 2021 May 14.

Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Dept. Orthopaedics, LUMC.

Objectives: Osteoarthritis (OA) is a complex genetic disease with different risk factors contributing to its development. One of the genes, TNFRSF11B, previously identified with gain-of-function mutation in a family with early-onset OA with chondrocalcinosis, is among the highest upregulated genes in lesioned OA cartilage (RAAK-study). Here, we determined the role of TNFRSF11B overexpression in development of OA. Read More

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Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes.

Front Cell Dev Biol 2021 26;9:622287. Epub 2021 Apr 26.

Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Basic calcium phosphate (BCP)-based calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of the disease and hypertrophic differentiation of chondrocytes. Chondrocalcinosis (CC) is associated with calcium pyrophosphate dihydrate (CPPD) deposition disease in the joint inducing OA-like symptoms. There is only little knowledge about the effect of CPPD crystals on chondrocytes and the signaling pathways involved in their generation. Read More

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Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca channel internalization in mesenchymal stem cells.

Bone Res 2020 Apr 26;8(1):19. Epub 2020 Apr 26.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

The loss-of-function mutations in the ALPL result in hypophosphatasia (HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain, chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Read More

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[Prevalence of hypophosphatasia in adult patients in rheumatology].

Z Rheumatol 2021 Apr 14. Epub 2021 Apr 14.

Klinik für Innere Medizin III, Onkologie, Hämatologie, Rheumatologie und Klinische Immunologie, Universitätsklinikum Bonn, Venusberg Campus 1, 53127, Bonn, Deutschland.

Background: Hypophosphatasia (HPP) is a genetic disorder caused by one or more mutations in the alkaline phosphatase (ALP) gene, responsible for encoding tissue-specific ALP and for the mineralization process.

Objective: Identification of the prevalence of HPP in rheumatology patients.

Material And Methods: Medical records of all adult rheumatology patients with pathologically low total ALP levels (<35 U/L) treated in the Department of Rheumatology at the Clinic of Internal Medicine III, University Hospital Bonn between January 2017 and June 2019, were retrospectively examined for clinical signs as well as for results of genetic tests for HPP. Read More

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20 Years of Radiographic Imaging: Crystalline Deposits Causing Severe Arthropathy and Erosions.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Rheumatology, Tripler Army Medical Center, Honolulu, HI 96859, USA.

Urate crystal gout arthritis and calcium pyrophosphate deposition disease (CPPD) are crystalline arthropathies seen in middle age to elderly patients, but are also seen in the active duty military population. Flares of either can be identified by acute joint pain, associated swelling, tenderness, and warmth. Definitive diagnosis involves synovial analysis from arthrocentesis. Read More

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Simultaneous Homozygous Mutations in and in an Inbred Chinese Pedigree.

Genes (Basel) 2021 03 5;12(3). Epub 2021 Mar 5.

Department of Nephrology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Long-quan Branch, Longquan 323716, China.

Gitelman syndrome (GS) and Bartter syndrome (BS) type III are both rare, recessively inherited salt-losing tubulopathies caused by and mutations, respectively. We described a 48-year-old male patient with fatigue, carpopedal spasm, arthralgia, hypokalemic alkalosis, mild renal dysfunction, hypomagnesemia, hypocalciuria, hyperuricemia, normotension, hyperreninemia and chondrocalcinosis in knees and Achilles tendons. His parents are first cousin. Read More

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Nodular Pseudogout of the Skull Base Arising From the Temporomandibular Joint.

J Craniofac Surg 2021 Jul-Aug 01;32(5):e475-e477

Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Tochigi 329-0498, Japan.

Abstract: The authors report a case of a rare, large, nodular pseudogout which developed from the temporomandibular joint (TMJ).An 83-year-old female was referred to the hospital with swelling on her left cheek. Imaging studies revealed a large calcified mass surrounding the left mandibular condyle, partially destroying the adjoining bone and extending to the skull base. Read More

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The Incidence and Significance of Calcium Pyrophosphate Dihydrate Deposits in Histologic Examinations of Total Hip, Knee, and Shoulder Joint Arthroplasties.

Arch Pathol Lab Med 2021 Mar 15. Epub 2021 Mar 15.

From the Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio (Dermawan, Kilpatrick, Reith).

Context.—: The incidence, distribution, and significance of calcium pyrophosphate dihydrate deposition (CPPD) disease have not been extensively compared among various total joint resections.

Objective. Read More

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Chondrocalcinosis does not affect functional outcome and prosthesis survival in patients after total or unicompartmental knee arthroplasty: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2021 Mar 6. Epub 2021 Mar 6.

Department of Orthopedic Surgery and Traumatology, Kantonsspital Baselland, 4101, Bruderholz, Switzerland.

Purpose: There are contentious data about the role calcium pyrophosphate (CPP) crystals and chondrocalcinosis (CC) play in the progression of osteoarthritis (OA), as well as in the outcomes after knee arthroplasty. Hence, the purpose of this systematic review was to analyse the clinical and functional outcome, progression of OA and prosthesis survivorship after unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in patients with CC compared to patients without CC.

Methods: A systematic review of the literature in PubMed, Medline, Embase and Web of Science was performed using the "Preferred Reporting Items for Systematic Reviews and Meta-Analysis" (PRISMA) guidelines. Read More

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Iliopsoas Bursitis Related to Calcium Pyrophosphate Deposition Disease.

Intern Med 2021 Aug 15;60(15):2515-2516. Epub 2021 Feb 15.

Department of General Internal Medicine, Akashi Medical Center, Japan.

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Influence of preoperative factors on timing for bilateral shoulder arthroplasty.

J Shoulder Elbow Surg 2021 Jul 8;30(7S):S116-S122. Epub 2021 Feb 8.

Shoulder Service, Florida Orthopaedic Institute, Tampa, FL, USA. Electronic address:

Introduction: In bilateral shoulder arthroplasty patients, it is unclear what features are responsible for the timing of their contralateral shoulder arthroplasty. This study hypothesized that patient factors (age, gender, and hand dominance), disease factors (diagnosis and radiographic severity of contralateral shoulder), and surgical factors (type of arthroplasty) impact the timing to contralateral surgery.

Methods: A retrospective review of 332 patients treated with bilateral anatomic (TSA) or reverse (RSA) shoulder arthroplasty (172 TSA/TSA, 107 RSA/RSA, or 53 TSA/RSA) were divided into groups depending on the interval timing between arthroplasty surgeries: group 1, n = 142 (≤1 year); group 2, n = 62 (1-2 years); and group 3, n = 128 (≥2 years). Read More

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Cervical myeloradiculopathy as an initial presentation of pseudogout.

Neurosciences (Riyadh) 2021 Jan;26(1):93-96

From the Department of Anesthesiology (Liao), Division of Neurosurgery (Hsieh), Department of Surgery Sijhih Cathay General Hospital, from the Department of Medicine (Hsieh), School of Medicine, Fu Jen Catholic University, New Taipei, from the Department of Neurological Surgery (Hsieh Sun), Tri-Service General Hospital, National Defense Medical Center, New Taipei, from the Section of Neurosurgery (Huang, Sun), Department of Surgery, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, and from the Department of Biotechnology (Sun), Asia University, Taichung, Taiwan.

Pseudogout, also known as calcium pyrophosphate deposition disease, is an inflammatory arthropathy that primarily occurs in the peripheral joints, such as the knee or elbow. Spinal pseudogout is uncommon, and neck pain is its most common clinical manifestation. However, cervical myeloradiculopathy as an initial presentation of pseudogout attack of the ligamentum flavum has rarely been reported in the literature. Read More

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January 2021

Pediatric idiopathic intervertebral disc calcification (IIDC): a challenging case.

Skeletal Radiol 2021 Jul 22;50(7):1473-1477. Epub 2021 Jan 22.

Pediatric Radiology Department, AP-HP, Bicêtre Hospital, 78 rue du General Leclerc, 94270, Le Kremlin-Bicêtre, France.

Idiopathic intervertebral disc calcification is a rare condition in children with a very good prognosis. As there are no biological markers, imaging is invaluable for diagnosing this "do not touch" lesion. While the characteristic feature is nucleus pulposus calcification at one or more cervical or thoracic levels, it is important that practitioners be able to recognize atypical patterns so that biopsy can be avoided. Read More

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Arthroscopic Superior Capsule Reconstruction for Cuff Tear Arthropathy (Hamada Grade 5): A Case Report.

JBJS Case Connect 2020 12 21;10(4):e20.00511. Epub 2020 Dec 21.

Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.

Case: We performed arthroscopic superior capsule reconstruction (ASCR) for cuff tear arthropathy (CTA) with humeral head deformity. A 62-year-old man presented with severely limited shoulder motion and recalcitrant omalgia. He had a history of dental implant removal due to metal allergy, and his Constant score was 21 points. Read More

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December 2020

Anakinra compared to prednisone in the treatment of acute CPPD crystal arthritis: A randomized controlled double-blinded pilot study.

Joint Bone Spine 2021 03 29;88(2):105088. Epub 2020 Oct 29.

Rheumatology Department, Lausanne University Hospital, avenue Pierre-Decker 4, 1005 Lausanne, Switzerland.

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Management of calcium pyrophosphate crystal deposition disease: A systematic review.

Semin Arthritis Rheum 2021 02 21;51(1):84-94. Epub 2020 Dec 21.

Department of Medicine, Division of Rheumatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Objective: Calcium pyrophosphate crystal deposition disease (CPPD) is a common cause of acute and chronic arthritis, especially in the elderly population. There is a paucity of data regarding the management of CPPD disease, which is currently based on expert opinion and evidence derived from the treatment of gout. We conducted a systematic literature review in order to identify the available treatment options for CPPD, and describe their efficacy and safety. Read More

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February 2021

[Recommendations for unicondylar knee replacement in the course of time : A current inventory].

Orthopade 2021 Feb;50(2):104-111

IZO - Internationales Zentrum für Orthopädie, ATOS Klinik Heidelberg, Heidelberg, Deutschland.

Background: A higher patient satisfaction stands in contrast to higher revision rates of unicondylar knee joint endoprosthetics (UKE) compared to total knee joint endoprosthetics (TKE). Furthermore, old "dogmas" regarding indications and contraindications persist, which is still reflected in the significantly different case numbers.

Aim: The aim of this article is to provide an overview of the current literature regarding 1. Read More

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February 2021

A critical review of the available evidence on the diagnosis and clinical features of CPPD: do we really need imaging?

Clin Rheumatol 2021 Jul 24;40(7):2581-2592. Epub 2020 Nov 24.

Academic Rheumatology, University of Nottingham, Nottingham, UK.

Imaging has been playing an important role in the pathogenetic and clinical characterisation of many rheumatic diseases, especially in the most recent years with the advent of many new, highly technological and promising techniques. Calcium pyrophosphate deposition disease (CPPD) benefited also from these new techniques, most of which can readily identify calcium crystals. Nowadays, imaging is used mainly to identify crystals in joints but given the complexity of CPPD, imaging should be used with an "holistic" approach in order to gain insights in the pathogenesis, spectrum of clinical manifestations and natural history of the disease. Read More

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Coincident cervical rheumatoid arthritis and CPP-D associated crowned dens syndrome.

Rheumatology (Oxford) 2021 05;60(5):2466

Division of Rheumatology, Immunology and Rehabilitation.

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Clinical implications of synovial fluid specimen handling for crystal associated arthritides: A systematic review.

Int J Rheum Dis 2021 Jan 5;24(1):10-20. Epub 2020 Nov 5.

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Aim: To identify the appropriate methods of synovial fluid (SF) specimen storage, manipulation and handling for crystal associated arthritides (CAA) diagnosis.

Method: A systematic literature review was conducted using 5 medical databases to identify diagnostic studies assessing SF specimen handling for calcium pyrophosphate (CPP) and monosodium urate (MSU) crystals identification. All included studies were rated for quality using the Quality Assessment of Diagnostic Accuracy Studies 2. Read More

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January 2021

Can Dual-Energy Computed Tomography Be Used to Identify Early Calcium Crystal Deposition in the Knees of Patients With Calcium Pyrophosphate Deposition?

Arthritis Rheumatol 2021 04 5;73(4):687-692. Epub 2021 Mar 5.

Lille Catholic University Hospital Group, MABLab ULR 4490, University of Lille, Lille, France.

Objective: To assess the ability of dual-energy computed tomography (DECT) in identifying early calcium crystal deposition in menisci and articular cartilage of the knee, depending on the presence/absence of chondrocalcinosis seen on conventional CT.

Methods: One hundred thirty-two knee DECT scans from patients with suspected crystal-associated arthropathy were reviewed and assigned to a calcium pyrophosphate deposition (CPPD) group (n = 50) or a control group (n = 82). Five DECT attenuation parameters were measured in preset regions of interest (ROIs) in menisci and articular cartilage and compared between groups using linear mixed models with adjustment for confounders. Read More

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Cervical myelopathy due to subaxial calcium pyrophosphate dihydrate (CPPD) deposition with simultaneous asymptomatic crowned dens syndrome: two case reports.

BMC Musculoskelet Disord 2020 Oct 31;21(1):713. Epub 2020 Oct 31.

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: There are few reports of cervical myelopathy caused by an attack of subaxial calcium pyrophosphate dihydrate (CPPD) deposition. Moreover, there has been no report on cervical myelopathy by subaxial CPPD deposition with simultaneous asymptomatic crowned dens syndrome (CDS) at the same time.

Case Presentation: The first case was a 68-year-old male complaining of cervical myelopathic symptoms. Read More

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October 2020

Cochrane in CORR®: Shoulder Replacement Surgery For Osteoarthritis And Rotator Cuff Tear Arthropathy.

Clin Orthop Relat Res 2020 11;478(11):2431-2433

L. Al Mana, K. Rajaratnam, Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, ON, Canada.

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November 2020