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BMC Musculoskelet Disord 2021 Apr 23;22(1):381. Epub 2021 Apr 23.

Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, 750004, People's Republic of China.

Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that commonly affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. The patella is an infrequent site. Read More

Semin Ultrasound CT MR 2021 Apr 29;42(2):123-133. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

Recent scholarship on enchondroma, chondrosarcoma, and chondroblastoma is presented. The focus of this article is on the imaging appearance of these tumors and the means by which they can be distinguished from one another by both clinical and imaging criteria. Read More

Cureus 2021 Feb 26;13(2):e13565. Epub 2021 Feb 26.

Medical Sciences, Keele University, Keele, GBR.

Background Bone tumours of the talus are a rare cause of ankle pain. This study aims to provide additional clinical clarity regarding the presentation and management of a minimally researched topic. Methods Sixteen patients were diagnosed with bone tumour of the talus between 2002 and 2020 following referral for ankle pain. Read More

BMJ Case Rep 2021 Feb 26;14(2). Epub 2021 Feb 26.

Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, Greater Manchester, UK.

Chondroblastomas are rare, benign cartilage-producing primary bone tumours that account for 1% of all primary bone tumours. They are usually seen in young adult males and affect long tubulous bones such as the femur or humerus. Occurrences in non-tubular flat bones such as the craniofacial skeleton do occur but are seen in older adults. Read More

J Vasc Interv Radiol 2021 04 19;32(4):504-509. Epub 2021 Feb 19.

Homi Bhabha National Institute, Anushaktinagar, Mumbai, Maharashtra 400094, India; Orthopedic Oncology, Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Dr Ernest Borges Road, Parel East, Parel, Mumbai, Maharashtra 400012, India.

Purpose: To evaluate safety and long-term efficacy of radiofrequency (RF) ablation in treatment of chondroblastoma.

Materials And Methods: This retrospective analysis comprised 27 consecutive patients with histopathologically proven chondroblastoma treated by RF ablation. The tumors were located in the proximal humerus (n = 6), proximal tibia (n = 8), proximal femur (n = 6), distal femur (n = 5), acromion process (n = 1), and lunate (n = 1). Read More

J Orthop Case Rep 2020 Sep;10(6):9-13

Department of Orthopaedics, Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction: Chondroblastoma is a rare primary benign tumor of bone with male predominance and is typically seen in an epiphyseal location. The pisiform is a carpal bone and chondroblastoma of the pisiform has not been reported in the literature to the best of our knowledge.

Case Presentation: An 18-year-old male presented with painful swelling over his right wrist with restriction of ulnar deviation. Read More

Int J Surg Pathol 2021 04 12;29(2):228-229. Epub 2021 Jan 12.

70566The Second Xiangya Hospital, Central South University, Changsha, China.

BMJ Case Rep 2020 Oct 29;13(10). Epub 2020 Oct 29.

Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India.

Clear cell chondrosarcoma is an extremely rare malignant neoplasm. The rarity and slow-growing nature of this tumour often lead to prolonged symptoms and also initial misdiagnosis with benign lesions such as chondroblastoma. It can also be confused with avascular necrosis of the femoral head when the lesion is located in the femoral head, as was in the case we report. Read More

Bull Cancer 2020 Nov 12;107(11):1186-1198. Epub 2020 Oct 12.

University Lille, CHU de Lille, service de chirurgie maxillo-faciale et stomatologie, U1008 - Controlled Drug Delivery Systems and Biomaterial, Inserm, 59000 Lille, France.

Benign and malign tumors can affect the temporomandibular joint (TMJ) as any other articulation. Nevertheless, TMJ tumors are rare and mostly benign. Their clinical expression is varied including symptomatology similar to TMJ dysfunctional disorders, otologic or neurologic pathologies. Read More

Med Arch 2020 Aug;74(4):312-314

Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Sultan Ismail, Malaysia.

Introduction: Chondroblastoma is an uncommon benign, locally destructive tumor that usually arises from epiphyses of the long bones. Temporal bone chondroblastoma is an extremely rare occurrence. Chondroblastoma arise from immature cartilage cells and it may display certain malignant features by invading surrounding structures and metastasizing to adjacent sites. Read More

JBJS Case Connect 2020 Jul-Sep;10(3):e1900480

1Division of Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Case: Two patients presenting to the clinic with midfoot pain were found to have pathologic fractures through chondroblastomas of the navicular bone. Patient 1 was a 15-year-old boy who experienced multiple recurrences despite more aggressive interventions. Patient 2 was a 13-year-old boy who experienced full recovery after lesion resection. Read More

Spine Deform 2021 Jan 21;9(1):297-301. Epub 2020 Aug 21.

Department of Pediatric Neurosurgery, Children's Hospital of New Orleans, New Orleans, LA, USA.

Purpose: Chondroblastoma is a cartilaginous neoplasm which rarely presents in the spine, where it has been shown to exhibit aggressive behavior. We present a case of a late diagnosis of a T12 chondroblastoma causing paraparesis in an 11-year-old girl. Several missed classical radiographic and clinical features are highlighted. Read More

Diagn Cytopathol 2021 Jan 12;49(1):46-53. Epub 2020 Aug 12.

Department of Clinical Pathology and Cytology, Karolinska University Hospital, Solna, Stockholm, Sweden.

Background: Clear-cell chondrosarcomas (CCCSs) constitute a very rare subtype of chondrosarcoma. CCCS may radiologically mimic chondroblastoma, and given the difference in surgical approach, it is important to distinguish these two entities preoperatively.

Design: Using the institutional digital records, we identified histologically verified CCCS between 1996 and 2013, where preoperative fine-needle aspiration (FNA) cytology was available. Read More

Orthopade 2020 Dec;49(12):1098-1102

Klinik für Allgemeine Orthopädie und Tumororthopädie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland.

We present the case of a 22-year-old female patient with chondroblastoma in the right humeral head. To allow a gentle and anatomic resurfacing of the humeral joint surface and to avoid total joint arthroplasty in our young patient with high functional requirements, we implanted a HemiCAP® after intralesional curettage of the chondroblastoma. Our patient's excellent short-term functional outcome shows that our approach can be considered a very good therapeutic option. Read More

Eur Arch Otorhinolaryngol 2021 Apr 13;278(4):1271-1276. Epub 2020 Jul 13.

Department of Otorhinolaryngology, Hôpital Lariboisière, Assistance Publique - Hôpitaux de Paris, Université de Paris, Inserm U1141, 2, rue Ambroise-Paré, 75010, Paris, France.

Purpose: To describe and analyse functional treatment of temporal bone chondroblastoma (TBCh).

Methods: From January 2000 to June 2019, at the Department of Otorhinolaryngology, Hôpital Lariboisière, Paris, France, patients with TBCh were enrolled in this study. All cases routinely performed pre-operatory work-up including evaluation of performance status, audio-vestibular function test, ear endoscopy, contrasted CT scan and MRI of head and neck region; in one case we also performed an angio-CT scan. Read More

J Pediatr Orthop 2020 Oct;40(9):e894-e897

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Purpose: Chondroblastoma is a benign, but potentially locally aggressive, bone tumor with predilection for the epiphysis of long bones in growing children. Historically, there is a reported 2% risk of lung metastasis, however these cases are mostly in the form of isolated single reports and the vast majority in adults. The purpose of this study was to identify the "true" risk of lung metastases at presentation in skeletally immature patients with a benign chondroblastoma, and therefore revisit the need for routine chest staging. Read More

Pediatr Radiol 2020 11 7;50(12):1724-1734. Epub 2020 Jul 7.

Department of Pediatric Radiology, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

Background: Solitary epiphyseal lesions are rare and present with nonspecific imaging features. Knowledge regarding etiologies of pediatric epiphyseal lesions is limited to small studies.

Objective: The purpose of this study was to determine the relative incidence of pathologies affecting the pediatric epiphysis based on biopsy-proven cases with imaging. Read More

World Neurosurg 2020 10 27;142:e260-e270. Epub 2020 Jun 27.

Section of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, Ermita, Manila, Philippines. Electronic address:

Objective: Chondroblastoma is an uncommon benign neoplasm of cartilaginous origin usually involving the long bones. The temporal bone is a rare location for this tumor. The clinical profile, optimal medical and surgical management, and outcomes of treatment for temporal bone chondroblastoma remain unknown. Read More

J Orthop Sports Phys Ther 2020 May;50(5):275

An 11-year-old female was referred to physical therapy due to a 3-month history of right medial knee pain. The patient's medical diagnosis was Osgood-Schlatter disease, based on radiographs obtained at the initial pediatrician consultation. An MRI scan was obtained 2 weeks after starting physical therapy and revealed a bony lesion near the medial condyle of the right femur and damage to medial joint structures. Read More

Int J Surg Case Rep 2020 19;70:8-12. Epub 2020 Apr 19.

Department of Orthopaedic Oncology and Surgery, Saitama Medical University International Medical Center, Japan.

Introduction: Surgery for chondroblastoma in the femoral head is challenging due to its inaccessibility, with high risk of local recurrence and poor functional outcomes reported. We herein report the first case of chondroblastoma in the femoral head treated by navigation-assisted surgery.

Presentation Of Case: A 12-year-old girl presented with persistent left hip pain and limited hip range of motion. Read More

World J Surg Oncol 2020 Mar 2;18(1):47. Epub 2020 Mar 2.

Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Chondroblastoma (CB) is a rare locally aggressive bone tumor that commonly occurs in the epiphysis or apophysis of long bones. Although surgical treatment of CB carries potential risk for physeal or articular cartilage damage, risk factors for joint degeneration have not been well described. In addition, we have mainly used synthetic bone substitute (SBS) to fill the bone defect after intralesional curettage as treatment for CB. Read More

Clin Imaging 2020 Jun 30;62:23-32. Epub 2020 Jan 30.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, United States of America.

Purpose: To describe the imaging, anatomic, and clinical features of a series of secondary aneurysmal bone cysts (ABC) and to ascertain their most commonly associated primary bone lesions.

Methods: Forty-nine cases of histopathologically proven secondary ABCs were retrospectively reviewed. Demographic data and clinical history were obtained. Read More

Pathologe 2020 Mar;41(2):106-115

Knochentumor-Referenzzentrum, Institut für Pathologie, Universitätsspital Basel, Universität Basel, Schönbeinstrasse 40, Basel, 4031, Schweiz.

The integrative evaluation of histology and corresponding imaging is essential for the classification of bone tumors. Until a few years ago, there were hardly any molecular markers that could be used for diagnostic purposes. However, exome- and genome-wide sequencing analyses have since uncovered a number of tumor-specific aberrations that can be very helpful in ambiguous cases. Read More

Arch Pathol Lab Med 2020 01;144(1):71-82

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

Context.—: Cartilaginous tumors represent one of the most common tumors of bone. Management of these tumors includes observation, curettage, and surgical excision or resection, depending on their locations and whether they are benign or malignant. Read More

Ann Diagn Pathol 2020 Feb 13;44:151440. Epub 2019 Dec 13.

Department of Surgical Oncology (Bone and Soft Tissues, DMG), Tata Memorial Centre, HBNI University, Parel, Mumbai 400012, India.

Chondroblastoma is a relatively uncommon, primary benign bone tumor, frequently identified in young individuals. Despite its classical radiologic and histopathological features, at times, it is fraught with a diagnostic challenge, especially differentiating it from a giant cell tumor of bone (GCTB); an osteosarcoma and a chondrosarcoma. Lately, few studies have shown the diagnostic utility of immunohistochemical (IHC) expression DOG1 antibody in chondroblastomas. Read More

World J Surg Oncol 2019 Dec 12;17(1):218. Epub 2019 Dec 12.

Department of Orthopedics, People's Hospital of Deyang City, Taishan North Road 173#, Deyang, 618000, Sichuan Province, People's Republic of China.

Background: Chondroblastoma is a rare primary bone tumor of young people that generally occurs in the epiphyseal plate of long bones. To date, only 13 cases of patella with pathological fracture in chondroblastoma have been previously published.

Case Presentation: A 15-year-old male patient presented with acute pain in the left knee after an injury occurred while playing basketball. Read More

Biomed Res Int 2019 29;2019:8206913. Epub 2019 Oct 29.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Objective: To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases.

Methods: Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Read More

Int J Surg Pathol 2020 Jun 26;28(4):447-453. Epub 2019 Nov 26.

Shimane University, Izumo, Shimane, Japan.

Tenosynovial giant cell tumor (TSGCT) of localized type is a common disease occurring mostly in the hands. Diagnosis of this tumor is relatively easy to render with hematoxylin-eosin-stained sections as compared with that of TSGCT of diffuse type. However, very rare cases with chondroid metaplasia that have recently been reported mainly in diffuse type can make pathological differentiation from soft tissue cartilaginous tumors extremely difficult. Read More

Genes Chromosomes Cancer 2020 04 15;59(4):217-224. Epub 2019 Nov 15.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Sclerosing epithelioid fibrosarcoma (SEF) is a rare sarcoma subtype characterized by monomorphic epithelioid cells embedded in a densely sclerotic collagenous matrix. The overwhelming majority of tumors arise in soft tissues; however, rare cases have been documented to occur primarily in bone. The hallmarks of soft tissue SEF include MUC4 immunoreactivity and the presence of an EWSR1-CREB3L1 fusion. Read More

JBJS Case Connect 2019 Jul-Sep;9(3):e0086

Department of Orthopaedics and Trauma Surgery, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Germany.

Case: A 38-year-old man presented with recurrent chondroblastoma of the acromion after primary curettage and bone grafting. The patient underwent revision surgery with resection of the acromion and reconstruction using an autologous iliac crest graft. He had regained normal shoulder function without recurrence at a follow-up of 17 months. Read More