1,335 results match your criteria Chondroblastoma


Spontaneous Conventional Osteosarcoma Transformation of a Chondroblastoma: A Case Report and Literature Review.

Indian J Orthop 2018 Nov-Dec;52(6):682

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

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December 2018

The diagnosis and treatment of tibial intercondylar chondroblastoma.

Clinics (Sao Paulo) 2018 Nov 29;73:e540. Epub 2018 Nov 29.

Emergency Department, Second Affiliated Hospital of the Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310090.

Objectives: To investigate the diagnosis and treatment of tibial intercondylar chondroblastoma.

Methods: We retrospectively analyzed the diagnosis and treatment of 12 patients with tibial intercondylar chondroblastoma admitted to the orthopedics department from May 2011 to February 2016; among them were 4 males and 3 females aged 10-19 years, with an average age of 15.7 years. Read More

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November 2018
2 Reads

Functional and Oncological Outcome After Treatment of Chondroblastoma With Intralesional Curettage.

J Pediatr Orthop 2018 Nov 8. Epub 2018 Nov 8.

Orthopedic Surgery Department, Faculty of Medicine, Menoufia University, Egypt.

Background: Chondroblastoma is a rare cartilaginous benign bone tumor that commonly arises in long bones of young people. Surgical management is the primary treatment of choice for chondroblastoma and it entails adequate intralesional curettage alone or in combination with adjuvants. This study was performed to describe the epidemiological characteristics and clinical and radiologic results of intralesional curettage of chondroblastoma. Read More

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November 2018
1.430 Impact Factor

Three dimensional surgical planning for mosaicplasty in chondroblastoma of femoral head with articular disruption.

J Orthop Sci 2018 Oct 31. Epub 2018 Oct 31.

Department of Orthopaedics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India. Electronic address:

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October 2018

Treatment of the benign lytic lesions of the proximal femur with synthetic bone graft.

J Orthop Surg Res 2018 Oct 29;13(1):270. Epub 2018 Oct 29.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: Benign bone tumors and tumor-like conditions are commonly located in the proximal femur. The main indications for surgical treatment are lesions with impending or actual pathological fractures, or with aggressive or recurrent lesions. However, patients complaining of persistent pain, limping, or abnormal gait patterns are also considered for surgical treatment. Read More

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October 2018
5 Reads

Chondroblastoma of the Foot: 40 Cases From a Single Institution.

J Foot Ankle Surg 2018 Nov - Dec;57(6):1105-1109

Professor, Department of Orthopedic and Orthopedic Oncology, University of Padova, Padova, Italy. Electronic address:

Chondroblastoma (CB) of the foot is a rare lesion. The purpose of this report was to report a large series from a single institution to analyze clinical, radiographic, and histologic characteristics; treatment; and local recurrence. We present 40 patients (30 males, 10 females; mean age 25 years) diagnosed and treated for CB of the foot from 1975 to 2012. Read More

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July 2015
4 Reads

Percutaneous Cryotherapy for Treatment of Chondroblastoma: Early Experience.

Cardiovasc Intervent Radiol 2018 Oct 16. Epub 2018 Oct 16.

Department of Interventional Radiology, Centre Léon Berard, 28 Prom. Léa Et Napoléon Bullukian, 69008, Lyon, France.

Surgical curettage is currently the standard of care for the chondroblastoma, but in peri-articular tumors it is limited by its morbidity. In this preliminary report, we evaluate the feasibility of percutaneous cryotherapy as an alternative ablative treatment for chondroblastoma. Three patients with a chondroblastoma treated by CT scan-guided cryotherapy are presented in this article. Read More

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October 2018
9 Reads

Prognostic factors to survival of patients with chondroblastic osteosarcoma.

Medicine (Baltimore) 2018 Sep;97(39):e12636

Department of Orthopedic Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Jiangsu, China.

This study was aimed to reveal the changes in survival rates and prognostic factors to survival of chondroblastic osteosarcoma (COS).Patients from the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. Kaplan-Meier survival analysis and Cox proportional hazard model were used during analysis. Read More

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September 2018

Chondroblastoma: An evaluation of the recurrences and functional outcomes following treatment.

Acta Orthop Traumatol Turc 2018 Sep 21. Epub 2018 Sep 21.

Department of Orthopedics and Traumatology, Metin Sabancı Baltalimanı Bone and Joint Diseases Training and Research Hospital, Istanbul, Turkey.

Objective: Chondroblastoma is a benign aggressive tumor which needs surgical treatment and has a recurrence rate up to 35%. Extended (aggressive) curettage is the mainstay of treatment and local adjuvants have been reported to decrease the recurrence rate.

Methods: The recurrence rates and the functional results of 14 patients who were treated in our institution and 2 other patients who were treated elsewhere between the years 2004-2016 were evaluated. Read More

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September 2018
12 Reads

Periostin expression in neoplastic and non-neoplastic diseases of bone and joint.

Clin Sarcoma Res 2018 5;8:18. Epub 2018 Sep 5.

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE UK.

Background: Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, we carried out immunohistochemistry and ELISA for periostin in a range of neoplastic and non-neoplastic bone and joint lesions.

Methods: 140 formalin-fixed paraffin-embedded sections of bone tumours and tumour-like lesions were stained by an indirect immunoperoxidase technique with a polyclonal anti-periostin antibody. Read More

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September 2018
3 Reads

Expansile radiolucent lesion of the Temporomandibular Joint-A diagnostic enigma.

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):203-205. Epub 2017 Jul 1.

Department of Oral Pathology, Government Dental College and Hospital, St. George Hospital Campus, Near Chhatrapati Shivaji Terminus Area, Fort, Mumbai, Maharashtra 400001, India.

Radiolucent lesions of Temporomandibular Joint (TMJ) represent a diagnostic challenge and a treatment conundrum. Biopsy of the lesions is technically difficult owing to their complex anatomy. The Differential Diagnosis (DD) includes a wide array of lesions including Simple Bone Cyst, Ameloblastoma, Central Giant Cell Granuloma, Hemangioma, Osteoblastoma, Osteochondroma, Chondroblastoma, Chondrosarcoma, Neurofibroma and metastatic malignant lesions though none has a specific predilection for TMJ. Read More

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July 2017
4 Reads

Updates in Primary Bone Tumors: Current Challenges and New Opportunities in Cytopathology.

Authors:
Xiaohua Qian

Surg Pathol Clin 2018 Sep;11(3):657-668

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

The review summarizes the current diagnostic challenges in fine-needle aspiration of primary bone tumors, with focus on the application of new molecular and immunohistochemical techniques in the diagnosis of giant cell-rich neoplasms, chondrosarcomas, and notochordal tumors. Read More

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September 2018
9 Reads

Bone tumors developed in patients with juvenile inflammatory arthritis after anti-TNFα therapy.

Immunotherapy 2018 Sep;10(12):1033-1039

Department of Rheumatology & Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Number 197 Ruijin Second Road, Shanghai 200025, China.

Administration of anti-TNFα agents has become a mainstay in the treatment of chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis. Adverse events, including infections and allergic reactions, have been reported. Malignancies are rare but potentially life threatening. Read More

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September 2018
2 Reads

Chondroblastoma of frontal bone: A tumor in an unusual location in a young child.

Clin Neuropathol 2018 Nov/Dec;37(6):288-291

Chondroblastomas are benign tumors of the osteoarticular system, involving long bones of skeletally immature individuals. Chondroblastomas of skull and facial bones are rare, with a predilection for temporal bone. We report the second case of chondroblastoma of frontal bone in world literature in an 8-year-old boy who presented with a painless swelling on the left side of the forehead increasing in size over 1 year. Read More

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October 2018
7 Reads

Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.

Adv Anat Pathol 2018 Nov;25(6):400-412

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms. Read More

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November 2018
12 Reads

Histone H3 Mutations in Cancer.

Curr Pharmacol Rep 2018 26;4(4):292-300. Epub 2018 Apr 26.

1Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. More recently, recurrent histone mutations have been identified in multiple cancers and have been shown to impede histone methylation. Read More

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Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome.

Pathol Res Pract 2018 Sep 7;214(9):1510-1513. Epub 2018 Aug 7.

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, 35249, United States.

Cardio-facio-cutaneous syndrome (CFCS) is a rare genetic disorder characterized by craniofacial deformities and heterogeneous cardiac and cutaneous manifestations. The condition is caused by de novo activating mutations in one of four genes encoding proteins involved in the RAS-MAPK signaling pathway; specifically BRAF, MEK1, MEK2, or KRAS. Variable malignancies have been reported in patients with CFCS. Read More

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September 2018
6 Reads

Histone H3K36M mutation and trimethylation patterns in chondroblastoma.

Histopathology 2018 Aug 11. Epub 2018 Aug 11.

Department of Pathology, Memorial Sloan Kettering Cancer Center, Great Neck, NY, USA.

Aims: Histones are essential components of chromatin, and mutations in histones lead to alterations in methylation and acetylation, which play an important role in tumorigenesis. Most of the chondroblastomas harbour the H3K36M mutation. With the availability of a mutation-specific antibody, we sought to assess the sensitivity of this antibody and the alterations of histone methylation in a series of chondroblastoma cases. Read More

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August 2018
13 Reads

Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations.

Methods Mol Biol 2018 ;1832:339-356

Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.

Recently, frequent somatic mutations at histone genes have been detected in high grade pediatric brain tumor, chondroblastoma, and giant cell tumor of bone. These mutant histones are also termed oncohistones. Since oncohistone proteins co-exist with wild type histone proteins in cells, it is critically important to understand how they promote tumorigenesis. Read More

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January 2018

Selected Giant Cell Rich Lesions of the Temporal Bone.

Head Neck Pathol 2018 Sep 1;12(3):367-377. Epub 2018 Aug 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55902, USA.

Giant cell rich lesions of the temporal bone encompass a wide spectrum of disease that includes infectious, reactive, and neoplastic processes. When dealing with any lesion that can potentially involve bone, it is important to understand both the clinical presentation and to correlate the histologic findings with the radiologic imaging. This review discusses the clinical, the pathologic features including the differential diagnosis, and the treatment of some of the more commonly encountered giant cell rich entities in this region. Read More

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September 2018
2 Reads

Diagnostic tools in the differential diagnosis of giant cell-rich lesions of bone at biopsy.

Oncotarget 2018 Jul 10;9(53):30106-30114. Epub 2018 Jul 10.

Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

The diagnosis of giant cell-rich lesions of bone can be challenging if radiological findings are ambiguous and tissue of the biologically deciding component is underrepresented in biopsy specimens. The frequent association of giant cell tumor of bone (GCT) and chondroblastoma (CB) with (secondary) aneurysmal bone cysts (ABC) may further impede correct classification. The present study evaluates the potentials and limitations of mutation-specific histone H3. Read More

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July 2018
11 Reads

Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center.

J Neurooncol 2018 Oct 2;140(1):99-106. Epub 2018 Jul 2.

Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Huangpu District, Shanghai, China.

Purpose: Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB.

Methods: Clinical data of 13 consecutive CB patients who received surgical treatment in our center between January 2006 and December 2016 were reviewed retrospectively. Read More

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October 2018
6 Reads

Unsintered Hydroxyapatite and Poly-L-Lactide Composite Screws/Plates for Stabilizing β-Tricalcium Phosphate Bone Implants.

Clin Orthop Surg 2018 Jun 18;10(2):253-259. Epub 2018 May 18.

Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan.

Unsintered hydroxyapatite (u-HA) and poly-L-lactide (PLLA) composites (u-HA/PLLA) are osteoconductive and biodegradable. Screw (Super-Fixsorb MX30) and plate (Super-Fixsorb MX40 Mesh) systems made of u-HA/PLLA are typically used in small bones in maxillofacial surgeries. After the resection of bone tumors in larger bones, reconstructions with β-tricalcium phosphate (β-TCP) implants of strong compression resistance have been reported. Read More

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June 2018
23 Reads

[Clinical observation of expanded curettage in treatment of chondroblastoma].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Dec;31(12):1438-1441

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha Hunan, 410008,

Objective: To explore the effectiveness of expanded curettage in the treatment of chondroblastoma.

Methods: The clinical data of 37 patients with chondroblastoma who were treated with expanded curettage between January 2011 and May 2016 were retrospectively analyzed. There were 24 males and 13 females, with a median age of 17 years (range, 12-30 years). Read More

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December 2017
4 Reads

[Treatment of benign bone lesions of proximal femur using dynamic hip screw and intralesional curettage via Watson-Jones approach].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Jan;32(1):31-35

Department of Musculoskeletal Tumor, the Second Hospital of Fuzhou Affiliated to Xiamen University, Fuzhou Fujian, 350007, P.R.China.

Objective: To explore the effectiveness of dynamic hip screw (DHS) and intralesional curettage via Watson-Jones approach in treatment of benign bone lesions of the proximal femur.

Methods : Between March 2012 and December 2016, 20 patients (21 lesions) with benign bone tumors or tumor like conditions of proximal femurs were treated with DHS and intralesional curettage via Watson-Jones approach. Their average age was 27. Read More

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January 2018
11 Reads

Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis.

Int J Surg Pathol 2018 Dec 18;26(8):766-771. Epub 2018 May 18.

1 University of Pennsylvania, Philadelphia, PA, USA.

Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an osteolytic lesion with adjacent area of sclerosis in the proximal left femur. Read More

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December 2018
3 Reads

Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy.

Cancer Cytopathol 2018 Aug 14;126(8):552-566. Epub 2018 May 14.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but are absent in histologic mimics. Mutation-specific immunohistochemistry (IHC) is highly specific for GCT and chondroblastoma in surgical excisions. Read More

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August 2018
9 Reads

Cystic bone tumors of the foot and ankle.

Authors:
Bashar Reda

J Surg Oncol 2018 Jun 3;117(8):1786-1798. Epub 2018 May 3.

Queen Elizabeth II Health Sciences Center, Halifax Infirmary, Dalhousie University, Halifax, Nova Scotia, Canada.

Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. Read More

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June 2018
1 Read

Chondroblastoma of the distal femoral metaphysis: A case report with emphasis on imaging findings and differential diagnosis.

Medicine (Baltimore) 2018 Apr;97(17):e0336

Department of Radiology.

Chondroblastoma is a rare benign tumor, consisting of tissue resembling foetal cartilage, and arising in the epiphyses, or apophyses of long tubular bone. However, chondroblastoma of the cortex of the long bone metaphysis is extremely rare.A 15-year-old girl presented a 10-month history of intermittent knee pain and without mobility limitation. Read More

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April 2018
3 Reads

[Benign and malignant giant-cell rich lesions of bone: Pathological diagnosis with special emphasis on recent immunohistochemistry and molecular techniques].

Ann Pathol 2018 Apr 23;38(2):92-102. Epub 2018 Mar 23.

Service d'anatomie pathologique et neuropathologie, department of pathology, CHU de Timone, Assistance publique-Hôpitaux de Paris (AP-HP), BMT-Timone 2, 2(e) étage, 264, rue Saint-Pierre, 13000 Marseille, France.

The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Read More

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April 2018
31 Reads

Spontaneous Conventional Osteosarcoma Transformation of a Chondroblastoma: A Case Report and Literature Review.

Indian J Orthop 2018 Jan-Feb;52(1):87-90

Department of Orthopaedic Surgery, University Malaya Medical Center, Jalan Universiti, Kuala Lumpur, Malaysia.

Chondroblastomas are a primary benign cartilaginous tumor that accounts for approximately 1% of all benign bone tumors. Primarily they are treated by curettage. The patient presented 4 years after a successfully treated chondroblastoma (curettage and Bone cement). Read More

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February 2018
8 Reads

The effects of surgical treatment with chondroblastoma in children and adolescents in open epiphyseal plate of long bones.

World J Surg Oncol 2018 Jan 23;16(1):14. Epub 2018 Jan 23.

Department of Orthopedics, West China Hospital, Sichuan University, No 37 Guo Xue Lane, Wuhou District, 610041, Chengdu, Sichuan, People's Republic of China.

Background: Chondroblastoma is a rare benign cartilaginous tumor, which primarily occurs in children and adolescents. Chondroblastoma commonly originates in the epiphyseal plate of long bones. An aggressive curettage treatment is recommended to manage lesion, which may jeopardize an open epiphyseal plate and result in limb shortening and deformity as the limb grows and develops. Read More

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January 2018
12 Reads

Oncohistones: drivers of pediatric cancers.

Genes Dev 2017 12;31(23-24):2313-2324

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

One of the most striking results in the area of chromatin and cancer in recent years has been the identification of recurrent mutations in histone genes in pediatric cancers. These mutations occur at high frequency and lead to the expression of mutant histones that exhibit oncogenic features. Thus, they are termed oncohistones. Read More

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December 2017
1 Read

Combined Autograft and Bone Cement for Painful Chondroblastoma: A Case Report.

J Foot Ankle Surg 2018 Mar - Apr;57(2):396-400. Epub 2018 Jan 4.

Orthopedic Surgeon, Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Chondroblastomas of the talus can lead to joint collapse and are often treated using curettage and bone grafting. In the present report, we describe the case of a 19-year-old female with a large chondroblastoma of the talus associated with a secondary aneurysmal cyst. We treated the large cartilage lesion, which involved most of the talus, with an iliac bone graft combined with bone cement to fill the large bone defect and preserve the subchondral bone of the articular surface of the dome of the talus. Read More

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September 2018
4 Reads

Aggressive curettage of a chondroblastoma-like osteosarcoma of the proximal end of the tibia. A case report with seven-year follow-up.

Skeletal Radiol 2018 Jun 6;47(6):853-857. Epub 2018 Jan 6.

Department of Pathology, Hospital Universitario de León, León, Spain.

A chondroblastoma-like osteosarcoma (CLO) in the proximal epiphysis and metaphysis of the tibia in a 30-year-old male is presented. With a wrong diagnosis of chondroblastoma, an aggressive curettage was performed. Later, the patient refused en-bloc resection. Read More

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June 2018
5 Reads

Chondroblastoma of the rib in a 47-year-old man: a case report with a systematic review of literature.

J Thorac Dis 2017 Oct;9(10):E907-E911

Department of Thoracic Surgery, AUSL Romagna Teaching Hospitals, Forlì, Italy.

Chondroblastoma is an uncommon benign bone tumour arising typically in the epiphysis. Few cases of chondroblastoma of the rib have been reported in the literature. We describe a case of chondroblastoma of a 47-year-old man located in the body of the IX right rib. Read More

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October 2017
6 Reads

Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR).

Pathol Res Pract 2018 Jan 2;214(1):89-94. Epub 2017 Nov 2.

Department of Pathology, Rizzoli Institute, Bologna, Italy. Electronic address:

Giant Cell Tumor (GCT) represents about 20% of benign bone tumors, is locally aggressive although malignant transformation is extremely rare, <1% of cases but 2-3% give pulmonary metastasis. Age at onset is between 20 and 40 years with a slight predominance for the female gender. GCT is characterized by specific mutations in H3F3A gene encoding the protein histone 3. Read More

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January 2018
14 Reads

Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone.

Hum Pathol 2018 Mar 12;73:41-50. Epub 2017 Dec 12.

Department of Anatomic Pathology, Graduate of School of Medical Science, Kyushu University, 812-8582, Fukuoka, Japan.

Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% have H3F3A gene mutation. The RANKL inhibitor denosumab, when used for the treatment of GCTB, leads to histological changes such as new bone formation and giant cell depletion. Here we assessed the diagnostic utility of immunohistochemical staining with the antibodies against histone H3. Read More

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March 2018
12 Reads

[Chondroblastoma].

Authors:
G Jundt D Baumhoer

Pathologe 2018 Mar;39(2):132-138

Knochentumor-Referenzzentrum und DÖSAK-Zentralregister am Institut für Pathologie, Universitätsspital Basel, Schoenbeinstraße 40, 4031, Basel, Schweiz.

Chondroblastomas are very rare benign primary bone tumors occurring preferentially in the epiphyses or apophyses of long bones in children and adolescents. In most cases the typical histological and imaging findings lead to a correct diagnosis that may be substantiated by demonstrating the highly specific point mutation in the H3F3B gene (p.K36M), either by sequencing or immunohistochemistry. Read More

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March 2018
13 Reads

Recap of the Knee Cap: A "Leave Alone" Lesion.

Ann Acad Med Singapore 2017 Oct;46(10):410-412

Department of Diagnostic Imaging, National University Hospital, Singapore.

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October 2017
2 Reads

An Active Giant Cell Tumor of the Patella: A Case Report.

Cureus 2017 Sep 2;9(9):e1642. Epub 2017 Sep 2.

Department of Orthopaedics and Traumatology, Medical University of Sofia, Bulgaria, University Hospital of Orthopaedics - Sofia.

Primary neoplasms of the patella account for less than 1% of all primary bone tumors of the lower extremity, the most frequent of them being the giant cell tumor of bone, the chondroblastoma, and the aneurysmal bone cyst. Herein, we report the case of a 29-year-old woman with an active giant cell tumor of the patella (GCTP) with its clinical and radiological features and a brief review of the literature. Read More

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September 2017
10 Reads

[New aspects on giant cell tumor of bone].

Pathologe 2018 Mar;39(2):125-131

Institut für Pathologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland.

A giant cell tumor of bone (GCTB) is one of the giant cell-rich lesions of bone and has to be differentiated from non-ossifying fibroma, aneurysmatic bone cyst, chondroblastoma, "brown tumor" and osteosarcoma containing giant cells. A hallmark of GCTB is the presence of the distinct histone 3 (H3F3A) mutation G34W and its detection either by sequencing methods or using immunohistochemistry with a novel antibody against this mutational site. Worrisome is the fact that under denosumab therapy a histological change of the lesions can be seen and there are first reports of sarcomas arising after therapy. Read More

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March 2018
12 Reads

A Rare Case of Chondroblastoma with Revision After Graft Rejection.

J Am Podiatr Med Assoc 2017 Sep;107(5):440-445

We present a rare case of calcaneal chondroblastoma with subsequent surgical revision after graft rejection in a 13-year-old boy. Complications were encountered after the injectable bone graft filler was placed in the calcaneus after curettage. With noted subsequent sinus tract formation, revision surgery was performed that involved dissection of the sinus tract, removal of bone void filler, and application of demineralized bone matrix sponge human allograft soaked in vancomycin-impregnated saline. Read More

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September 2017
14 Reads

"Chondroblastoma-like" epithelioid fibrous histiocytoma: A previously undescribed and potentially confusing variant.

J Cutan Pathol 2018 Feb 10;45(2):99-103. Epub 2017 Dec 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Background: Epithelioid benign fibrous histiocytoma has been considered a variant of fibrous histiocytoma, but is now considered a distinct entity, typically showing ALK expression. Most show typical morphological features, including an epidermal collarette and large, bland, epithelioid cells. We have recently encountered 2 examples showing an unusual pattern of pericellular calcification, a previously unreported finding. Read More

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February 2018
12 Reads

Chondroblastoma of extra-craniofacial bones: Clinicopathological analyses of 103 cases.

Pathol Int 2017 Oct;67(10):495-502

Department of Pathology, Kyoto Prefectural University of Medicine Graduate School of Medicine, Kyoto, Japan.

We elucidated clinicopathological characteristics of chondroblastoma (CB) in Japan, and reliable clinicopathologic parameters predicting local recurrence and/or metastasis. Clinicopathological profiles of 103 CB (80 male, 23 female) in extra-craniofacial bones were retrieved. Numerical scoring of nine pathological and five radiological features was statistically analyzed to determine prognostic significance. Read More

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October 2017
24 Reads

Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.

Hum Pathol 2017 10 9;68:128-135. Epub 2017 Sep 9.

Section of Anatomic Pathology, Department of Surgery and Translational Medicine, University of Florence, 50134, Florence, Italy. Electronic address:

Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3. Read More

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October 2017
8 Reads

Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors.

Hum Pathol 2017 10 4;68:119-127. Epub 2017 Sep 4.

University of Calgary/Calgary Laboratory Services, Department of Pathology and Laboratory Medicine, Calgary, AB, Canada, T2N 2T9. Electronic address:

Differentiating osteoclast-rich lesions of bone (giant cell tumor of bone [GCTB], chondroblastoma [CBA], and aneurysmal bone cyst [ABC]) can be challenging, especially in small biopsies or fine-needle aspirations. Mutations affecting codons 34 and 36 of either H3 Histone Family Member 3A (H3F3A) and/or 3B (H3F3B) are characteristically seen in GCTB and CBAs. We devised a simple assay to identify these mutations and evaluated its applicability for routine clinical diagnosis. Read More

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October 2017
7 Reads

An unusual localization of chondroblastoma: The triradiate cartilage; from a case report a reconstructive technique proposal with imaging evolution.

J Clin Orthop Trauma 2017 Aug 24;8(Suppl 1):S48-S52. Epub 2017 Jul 24.

Department of Applied Clinical Science & Biotechnology, University of L'Aquila, Piazzale Salvatore Tommasi 1, L'Aquila, Italy.

Introduction: Chondroblastoma (also known as Codman tumor) is a rare intermediate grade cartilaginous neoplasm, representing less than 1% of all primary bone tumors; it characteristically arises in the epiphysis or apophysis of a long bone in young patients, predominantly males. The most frequent location of chondroblastoma is the humerus (70% incidence rate) and more rarely it is located in the pelvis. When it affects the hip, the triradiate cartilage is the most common site. Read More

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August 2017
24 Reads

Unusual presentation of chondroblastoma mimicking Trevor's disease.

Authors:
A V Nair S Anirudh

J Postgrad Med 2017 Oct-Dec;63(4):273

Department of Pathology, Medical College Hospital, Trivandrum, Kerala, India.

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September 2017
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Intraoperative crush smear cytology of vertebral chondroblastoma: A diagnostic challenge.

Diagn Cytopathol 2018 Jan 23;46(1):79-82. Epub 2017 Aug 23.

Department of Pathology, Superspeciality Hospital and Government Medical College, Nagpur, Maharashtra, India.

Chondroblastoma is a rare, cartilage producing primary neoplasm of the bone. Although generally benign, chondroblastoma is placed in the "intermediate, rarely metastasizing" category in the 2013 World Health Organization classification of bone tumors. It typically involves the epiphysis of long tubular bones and is exceptionally located in the vertebral column. Read More

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January 2018
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