1,445 results match your criteria Chondroblastoma


Epithelioid Fibrous Histiocytoma With Chondroblastoma-Like Features: A Report of a Rare Entity and Discussion of Related Diagnostic Challenges.

Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority (Central Zone), Halifax, NS, Canada; Department of Ophthalmology, Nova Scotia Health Authority (Central Zone), Halifax, NS, Canada; Departments of Ophthalmology and Visual Sciences, Pathology, and; Medicine, Dalhousie University, Halifax, NS, Canada; and Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority (Western Zone), Kentville, NS, Canada.

Abstract: Epithelioid fibrous histiocytoma (EFH) is an uncommon benign skin lesion. It is distinct from FH by virtue of its recurrent anaplastic lymphoma kinase (ALK) gene rearrangements and immunohistochemical expression of ALK protein. It often poses a challenge in interpretation. Read More

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Prognostic Significance of Tumor-Associated Macrophages in Chondroblastoma and Their Association with Response to Adjuvant Radiotherapy.

J Inflamm Res 2021 17;14:1991-2005. Epub 2021 May 17.

Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, 421001, People's Republic of China.

Objective: Chondroblastoma (CB) is a rare and locally growing cartilage-derived tumor. Currently, clinical implications of tumor-associated macrophages (TAMs) in CB remain unclear. In this study, we sought to analyze the relationship between TAM parameters (including densities of CD68+ and CD163+ cells as well as the CD163+/CD68+ ratio) and clinicopathological characteristics and survival of patients. Read More

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Treatment of Chondroblastoma with Denosumab: A Case Report with a Correlative Analysis of Effect on the RANK Signaling Pathway.

JBJS Case Connect 2021 05 17;11(2). Epub 2021 May 17.

Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina.

Case: A 15-year-old boy with chondroblastoma of the right hemipelvis presented with significant periacetabular bone destruction. Neoadjuvant denosumab treatment facilitated initial joint preserving surgery. Unfortunately, he experienced 2 local recurrences and underwent wide surgical resection 2 years after his initial diagnosis. Read More

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'Umbrella construct' - an innovative technique for reconstruction of the proximal humerus after curettage in locally aggressive benign bone tumours.

Shoulder Elbow 2021 Apr 10;13(2):188-194. Epub 2020 Jan 10.

Department of Bone and Soft Tissue Tumors, Tata Memorial Hospital, Mumbai, India.

Aim: Reconstructing locally aggressive benign bone tumours of the proximal humerus after intralesional curettage is a challenge. We present a novel reconstruction technique '' where a femoral head and a strut allograft are combined to reconstruct the cavity. Complications, graft incorporation time, functional (Musculoskeletal Tumor Society score [MSTS]) and oncological outcomes were evaluated. Read More

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Clinicopathological and Prognostic Characteristics in Spinal Chondroblastomas: A Pooled Analysis of Individual Patient Data From a Single Institute and 27 Studies.

Global Spine J 2021 Apr 26:21925682211005732. Epub 2021 Apr 26.

Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, China.

Study Design: Retrospective pooled analysis of individual patient data.

Objectives: Spinal chondroblastoma (CB) is a very rare pathology and its clinicopathological and prognostic features remain unclear. Here, we sought to characterize the clinicopathological data of a large spinal CB cohort and determine factors affecting the local recurrence-free survival (LRFS) and overall survival (OS) of patients. Read More

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Chondroblastoma of the patella with secondary aneurysmal bone cyst, an easily misdiagnosed bone tumor:a case report with literature review.

BMC Musculoskelet Disord 2021 Apr 23;22(1):381. Epub 2021 Apr 23.

Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, 750004, People's Republic of China.

Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that commonly affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. The patella is an infrequent site. Read More

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The dark side of histones: genomic organization and role of oncohistones in cancer.

Clin Epigenetics 2021 Apr 7;13(1):71. Epub 2021 Apr 7.

Department of Biomolecular Sciences, Molecular Pathology Laboratory "PaoLa", University of Urbino Carlo Bo, Via Arco d'Augusto 2, 61032, Fano, PU, Italy.

Background: The oncogenic role of histone mutations is one of the most relevant discovery in cancer epigenetics. Recurrent mutations targeting histone genes have been described in pediatric brain tumors, chondroblastoma, giant cell tumor of bone and other tumor types. The demonstration that mutant histones can be oncogenic and drive the tumorigenesis in pediatric tumors, led to the coining of the term "oncohistones. Read More

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Chondroid Tumors of Bone.

Semin Ultrasound CT MR 2021 Apr 29;42(2):123-133. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

Recent scholarship on enchondroma, chondrosarcoma, and chondroblastoma is presented. The focus of this article is on the imaging appearance of these tumors and the means by which they can be distinguished from one another by both clinical and imaging criteria. Read More

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Bone Tumours of the Talus: 18-Year Cohort of Patients With Rare Osteoid Lesions.

Cureus 2021 Feb 26;13(2):e13565. Epub 2021 Feb 26.

Medical Sciences, Keele University, Keele, GBR.

Background Bone tumours of the talus are a rare cause of ankle pain. This study aims to provide additional clinical clarity regarding the presentation and management of a minimally researched topic. Methods Sixteen patients were diagnosed with bone tumour of the talus between 2002 and 2020 following referral for ankle pain. Read More

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February 2021

In Reply to the Letter to the Editor regarding "Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes".

World Neurosurg 2021 Apr;148:236

Division of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. Electronic address:

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Letter to the Editor Regarding "Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes".

World Neurosurg 2021 Apr;148:235

Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China. Electronic address:

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The incorporation loci of H3.3K36M determine its preferential prevalence in chondroblastomas.

Cell Death Dis 2021 Mar 24;12(4):311. Epub 2021 Mar 24.

Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, 310058, Hangzhou, Zhejiang, China.

The histone H3.3K36M mutation, identified in over 90% of chondroblastoma cases, reprograms the H3K36 methylation landscape and gene expression to promote tumorigenesis. However, it's still unclear how the H3K36M mutation preferentially occurs in the histone H3 variant H3. Read More

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Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis.

Mod Pathol 2021 Mar 16. Epub 2021 Mar 16.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.

Translocations involving FN1 have been described in a variety of neoplasms that share the presence of a cartilage matrix and may also contain a variable extent of calcification. Fusions of FN1 to FGFR1 or FGFR2 have been reported in nine soft tissue chondromas, mostly demonstrated indirectly by FISH analysis. Delineation of FN1 fusions with various partner genes will facilitate our understanding of the pathogenesis and diagnostic classification of these neoplasms. Read More

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[The H3.3 K36M mutation protein expression of H3.3 in chondroblastoma: a novel diagnostic biomarker].

Zhonghua Bing Li Xue Za Zhi 2021 Mar;50(3):242-244

Department of Pathology, Beijing Jishuitan Hospital (the Fourth Medical College of Peking University), Beijing 100035, China.

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Surgical Strategy of Pediatric Benign Sacral Tumors.

J Pediatr Orthop 2021 Apr;41(4):227-235

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China.

Background: Primary benign osseous tumors and tumor-like lesions at the sacrum are rare in the pediatric population and exact surgical strategy is still unclear. In this study, we evaluate the outcome for pediatric patients with benign tumors and tumor-like lesions at the sacrum who were receiving surgical treatment according to our proposed surgical strategy and classification.

Methods: We analyzed 49 pediatric patients with sacral benign tumors or tumor-like lesions aged 18 years and below from 2005 to 2018. Read More

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Skull base chondroblastoma presenting as a deep lobe parotid tumour.

BMJ Case Rep 2021 Feb 26;14(2). Epub 2021 Feb 26.

Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, Greater Manchester, UK.

Chondroblastomas are rare, benign cartilage-producing primary bone tumours that account for 1% of all primary bone tumours. They are usually seen in young adult males and affect long tubulous bones such as the femur or humerus. Occurrences in non-tubular flat bones such as the craniofacial skeleton do occur but are seen in older adults. Read More

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February 2021

H3.3 K36M Mutation as a Clinical Diagnosis Method of Suspected Chondroblastoma Cases.

Orthop Surg 2021 Apr 23;13(2):616-622. Epub 2021 Feb 23.

Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Whether H3.3 K36M mutation (H3K36M) could be an approach if the diagnosis of chondroblastoma (CB) patients was indistinct and it was suspected to be unclear clinically.

Methods: We reviewed and compared our clinical experiences of CB cases and some suspected cases, which were not diagnosed distinctly, between 2013 to 2019. Read More

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Percutaneous Radiofrequency Ablation of Appendicular Skeleton Chondroblastoma-an Experience from a Tertiary Care Cancer Center.

J Vasc Interv Radiol 2021 04 19;32(4):504-509. Epub 2021 Feb 19.

Homi Bhabha National Institute, Anushaktinagar, Mumbai, Maharashtra 400094, India; Orthopedic Oncology, Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Dr Ernest Borges Road, Parel East, Parel, Mumbai, Maharashtra 400012, India.

Purpose: To evaluate safety and long-term efficacy of radiofrequency (RF) ablation in treatment of chondroblastoma.

Materials And Methods: This retrospective analysis comprised 27 consecutive patients with histopathologically proven chondroblastoma treated by RF ablation. The tumors were located in the proximal humerus (n = 6), proximal tibia (n = 8), proximal femur (n = 6), distal femur (n = 5), acromion process (n = 1), and lunate (n = 1). Read More

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A Destructive Tumor of the Proximal Tibia and Fibula: A Case Report Highlighting Challenging Diagnosis and Treatment of a Locally Advanced, Non-recurrent Chondroblastoma in 16 Years Old Patient.

J Orthop Case Rep 2020 Oct;10(7):63-67

Department of Orthopaedic Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States.

Introduction: Chondroblastoma is a rare, cartilaginous primary bone tumor, which presents predominantly in children and young adults. These tumors represent 1% of all primary bone tumors. Patients tend to complain of progressive joint pain which usually aids in early diagnosis. Read More

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October 2020

Preliminary proposal: a classification system for reconstruction with autologous femoral head after periacetabular tumors resection.

J Orthop Surg Res 2021 Feb 8;16(1):119. Epub 2021 Feb 8.

Department of Orthopedic Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China.

Background: Although researchers have adopted various methods for the resection and reconstruction of periacetabular tumors, the total incidence rate of complications remains high. Aiming for preserving the acetabulum and reducing the risk of complications, we applied a surgery method using tumor-free autologous femoral head to reconstruct the defective acetabulum after resection of periacetabular tumors followed by performing a conventional total hip arthroplasty (THA). Moreover, we proposed a preliminary classification system for these surgery methods. Read More

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February 2021

Usefulness of β-catenin expression in the differential diagnosis of osteosarcoma, osteoblastoma, and chondroblastoma.

Virchows Arch 2021 Jan 28. Epub 2021 Jan 28.

Department of Pathology, Azienda Ospedaliera di Padova, Padua, Italy.

The aim of this study is to assess the usefulness of beta-catenin immunohistochemical expression in the differential diagnosis of osteoid-producing primary tumors of bone. Seventy cases of osteoid-producing tumors of bone (24 conventional osteosarcomas, 18 osteoblastomas, 13 osteoblastoma-like osteosarcomas, 10 chondroblastomas, and 5 chondroblastoma-like osteosarcomas) diagnosed at Istituto Ortopedico Rizzoli were reviewed and evaluated for the intensity, extension, and subcellular distribution of immunohistochemical expression of beta-catenin. A majority of cases (73%, 51 cases) exhibited cytoplasmic and/or membranous positivity in varied degrees of intensity and proportion of positive cells, in the absence of nuclear staining. Read More

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January 2021

Non-vascularised Fibular Autograft for Reconstruction of Paediatric Bone Defects: An Analysis of 10 Cases.

Strategies Trauma Limb Reconstr 2020 May-Aug;15(2):84-90

Department of Orthopaedics, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

Aim And Objective: Fibular autograft is a known technique for the reconstruction of traumatic and non-traumatic bone defects in both adult and paediatric populations. We aim to describe our outcomes using various stabilisation methods for non-vascularised fibular autograft to reconstruct both benign and malignant tumours in a paediatric population in a National Paediatric Centre over the past 14 years.

Materials And Methods: This was a retrospective review of 10 paediatric cases with non-traumatic primary bone defects in a National Paediatric Centre. Read More

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January 2021

A Rare Case Report of Chondroblastoma Pisiform in Adolescent.

J Orthop Case Rep 2020 Sep;10(6):9-13

Department of Orthopaedics, Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction: Chondroblastoma is a rare primary benign tumor of bone with male predominance and is typically seen in an epiphyseal location. The pisiform is a carpal bone and chondroblastoma of the pisiform has not been reported in the literature to the best of our knowledge.

Case Presentation: An 18-year-old male presented with painful swelling over his right wrist with restriction of ulnar deviation. Read More

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September 2020

Partial Articular Resurfacing Secondary to Pediatric Hip Chondroblastoma Curettage with a 5-YearFollow-Up: A Case Report.

JBJS Case Connect 2021 Jan 14;11(1):e20.00297. Epub 2021 Jan 14.

Orthopaedic Department, Beacon Hospital, Dublin, Ireland.

Case: This report describes a case of pediatric femoral head chondroblastoma, which was initially treated by minimally invasive curettage. At the 18-month follow-up, a subsequent osteochondral defect occurred, which was treated with a partial articular resurfacing system. At 5. Read More

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January 2021

Primary sclerosing epithelioid fibrosarcoma of the spine: a single-institution experience.

Histopathology 2021 Jun 14;78(7):976-986. Epub 2021 Apr 14.

Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Aims: To present our experience on spinal sclerosing epithelioid fibrosarcoma (SEF) and review the existing literature pertaining to SEF of the spine.

Methods And Results: Six cases of spinal SEF were reviewed, and a literature search of all primary SEFs of the spine was performed. All tumours occurred in adults (median age, 41 years) and were located all along the spine, the lumbar vertebrae being the most commonly involved. Read More

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Analysis for clinical feature and outcome of chondroblastoma after surgical treatment: A single center experience of 92 cases.

J Orthop Sci 2021 Jan 5. Epub 2021 Jan 5.

Peking University People's Hospital, Musculoskeletal Tumor Center, No. 11 Xizhimen South Street, 100044, Beijing, China. Electronic address:

Background: Chondroblastoma is a rare, benign, cartilaginous bone tumor derived from epiphyseal chondrocytes. Although the clinical characteristics and experience of surgical treatment of the smaller number of patients has been reported in the literature, it is difficult to draw conclusions about the clinical and radiographic features and the outcome for surgical treatment of this disease due to the rarity of chondroblastoma. This study was aiming to review the epidemiologic characteristics and outcome of surgical management for patients with chondroblastoma. Read More

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January 2021

Chondroblastoma: Is intralesional curettage with the use of adjuvants a sufficient way of therapy?

J Bone Oncol 2021 Feb 5;26:100342. Epub 2020 Dec 5.

Department of Orthopedics and Tumororthopedics, University Hospital Munster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.

Background: Chondroblastoma is a rare benign cartilaginous bone tumor that represents 1-2% of all primary bone tumors. It is characterized by aggressive growth, possible recurrence after surgical treatment and, in rare cases, metastasis. Surgical management is the primary treatment and includes intralesional curettage with or without adjuvants. Read More

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February 2021

Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital.

Acta Cytol 2021 12;65(1):75-87. Epub 2020 Nov 12.

Department of Orthopaedics, Nizams Institute of Medical Sciences, Hyderabad, India.

Aim: The aim is to study the utility of fine-needle aspiration cytology (FNAC) in preoperative diagnosis of bone lesions in correlation with radiological and histopathological findings and to determine the spectrum and morphological features of various bone lesions on FNAC.

Materials And Methods: A total of 275 cases of bone lesions were studied by FNAC over a period of 3 years. 196 procedures were performed by pathologists, and 107 procedures were guided. Read More

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January 2021