1,389 results match your criteria Chondroblastoma


Temporal bone chondroblastoma: systematic review of clinical features and outcomes.

World Neurosurg 2020 Jun 27. Epub 2020 Jun 27.

Section of Neurosurgery, Department of Neurosciences.

Objectives: Chondroblastoma is an uncommon benign neoplasm of cartilaginous origin usually involving the long bones. The temporal bone is a rare location for this tumor. As such, the clinical profile, optimal medical and surgical management, and outcomes of treatment for temporal bone chondroblastoma remain unknown. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.192DOI Listing

Chondroblastoma in the Sphenoid Sinus.

Ear Nose Throat J 2020 Jun 30:145561320934225. Epub 2020 Jun 30.

Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Long is now with the Department of Otorhinolaryngology, Sichuan University Hospital of Sichuan University, Chengdu, Sichuan, China. Li is now with the Department of Otorhinolaryngology, Nanchong Central Hospital, Nanchong, Sichuan, China.

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http://dx.doi.org/10.1177/0145561320934225DOI Listing

Clinicopathologic characterization of malignant chondroblastoma: a neoplasm with locally aggressive behavior and metastatic potential that closely mimics chondroblastoma-like osteosarcoma.

Mod Pathol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Chondroblastoma is currently classified as a benign neoplasm; however, chondroblastoma and chondroblastoma-like osteosarcoma have morphologic overlap, raising the possibility that some tumors diagnosed as chondroblastoma-like osteosarcoma might actually represent malignant chondroblastoma. The H3F3B K36M point mutation, which has not been reported in osteosarcoma, is identified in 95% of chondroblastomas and is reliably detectable by immunohistochemistry (IHC). We reviewed 11 tumors diagnosed as atypical chondroblastoma, malignant chondroblastoma, or chondroblastoma-like osteosarcoma (median follow-up: 8. Read More

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http://dx.doi.org/10.1038/s41379-020-0604-2DOI Listing

Metastasizing chondroblastoma: a rare bone tumor no longer supported by the WHO classification.

Skeletal Radiol 2020 Jun 27. Epub 2020 Jun 27.

Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

According to the World Health Organization (WHO) classification, tumors showing hematogenous spread in less than 2% of cases are categorized as "rarely metastasizing" and constitute a group of neoplasms of intermediate malignancy. Since its introduction in 2002, chondroblastoma has been considered one of the prototypic examples of this category of lesions. In the fifth and only recently published edition of the WHO classification of bone and soft tissue tumors, however, chondroblastoma was re-classified from rarely metastasizing to benign due to the rarity of cases with systemic spread. Read More

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http://dx.doi.org/10.1007/s00256-020-03525-6DOI Listing

Clinicopathologic Analysis of Chondroblastoma in Adults: A Single-Institution Case Series.

Int J Surg Pathol 2020 Jun 2:1066896920927794. Epub 2020 Jun 2.

Johns Hopkins University, Baltimore, MD, USA.

Chondroblastoma is a rare benign tumor of immature cartilage cells that generally occurs in an epiphyseal location of skeletally immature individuals. However, a few studies have reported cases in older patients. The purpose of this study was to evaluate the clinical, radiographic, and pathologic features of chondroblastoma in an adult population. Read More

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http://dx.doi.org/10.1177/1066896920927794DOI Listing

Tumours of the talus - A pictorial review.

J Clin Orthop Trauma 2020 May-Jun;11(3):410-416. Epub 2020 Apr 11.

Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital, Birmingham, UK.

Background: Primary bone tumours of the talus are a rare entity and seldom described in the literature. Due to this, often the diagnosis and management of such cases are delayed. This study aims to describe a spectrum of lesions identified within our department and provide a pictorial review with the goal to aid radiologists in the evaluation and diagnosis of such lesions. Read More

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http://dx.doi.org/10.1016/j.jcot.2020.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211828PMC

Total Calcanectomy and Bilateral Iliac Bone Autograft Reconstruction for the Treatment of Calcaneal Chondroblastoma Involving a Secondary Aneurysmal Bone Cyst: A Case Report and Literature Review.

J Foot Ankle Surg 2020 May - Jun;59(3):616-624

Surgeon and Professor, Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Chondroblastoma is a rare, benign, cartilaginous-derived tumor accounting for ∼1% to 2% of all primary bone tumors and almost 9% of all benign bone tumors. In this case report, we describe a patient with chondroblastoma and a secondary aneurysmal bone cyst, with the adjacent talus being mildly affected. The initial diagnosis was giant cell tumor and was then confirmed after computed tomography-assisted biopsy. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.10.001DOI Listing
February 2019
0.979 Impact Factor

Chondroblastoma of the Distal Femur in an Adolescent.

J Orthop Sports Phys Ther 2020 May;50(5):275

An 11-year-old female was referred to physical therapy due to a 3-month history of right medial knee pain. The patient's medical diagnosis was Osgood-Schlatter disease, based on radiographs obtained at the initial pediatrician consultation. An MRI scan was obtained 2 weeks after starting physical therapy and revealed a bony lesion near the medial condyle of the right femur and damage to medial joint structures. Read More

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http://dx.doi.org/10.2519/jospt.2020.9021DOI Listing

Navigation-assisted surgery for chondroblastoma arising in the femoral head: A case report.

Int J Surg Case Rep 2020 19;70:8-12. Epub 2020 Apr 19.

Department of Orthopaedic Oncology and Surgery, Saitama Medical University International Medical Center, Japan.

Introduction: Surgery for chondroblastoma in the femoral head is challenging due to its inaccessibility, with high risk of local recurrence and poor functional outcomes reported. We herein report the first case of chondroblastoma in the femoral head treated by navigation-assisted surgery.

Presentation Of Case: A 12-year-old girl presented with persistent left hip pain and limited hip range of motion. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183096PMC

Management of cranial chondroblastoma in adults; a pooled analysis.

Am J Otolaryngol 2020 Jul - Aug;41(4):102486. Epub 2020 Apr 10.

Clinical Oncology Department, Sohag University Hospital, Egypt.

Objectives: Chondroblastoma is a rare bone tumour that often affects children more than adults. The adult cranial affection is a unique presentation of the disease (less than 2%) that mandates specific management. Through this pooled-analysis, we aimed to examine this disease group and obtain reliable scientific conclusions. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102486DOI Listing

Calcium pyrophosphate deposition disease: A case report with bilateral involvement of the temporomandibular joints and concurrence of psoriatic arthritis.

Clin Case Rep 2020 Apr 5;8(4):640-643. Epub 2020 Feb 5.

Department of Oral Surgery and Oral Medicine Faculty of Dentistry University of Oslo Oslo Norway.

Calcium pyrophosphate dehydrate deposition (CPDD) disease very rarely affects the temporomandibular joint (TMJ). It may resemble synovial chondromatosis, chondrosarcoma, chondroblastoma, or a parotid tumor. Clinical examination, CT, and MRI are important in making the correct diagnosis. Read More

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http://dx.doi.org/10.1002/ccr3.2715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141746PMC

Clinical outcomes of chondroblastoma treated using synthetic bone substitute: risk factors for developing radiographic joint degeneration.

World J Surg Oncol 2020 Mar 2;18(1):47. Epub 2020 Mar 2.

Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Chondroblastoma (CB) is a rare locally aggressive bone tumor that commonly occurs in the epiphysis or apophysis of long bones. Although surgical treatment of CB carries potential risk for physeal or articular cartilage damage, risk factors for joint degeneration have not been well described. In addition, we have mainly used synthetic bone substitute (SBS) to fill the bone defect after intralesional curettage as treatment for CB. Read More

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http://dx.doi.org/10.1186/s12957-020-01829-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053063PMC

[Giant cell tumor of bone : Morphology, molecular pathogenesis, and differential diagnosis].

Pathologe 2020 Mar;41(2):134-142

Institut für Pathologie, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland.

The histological picture of giant cell tumor of bone is characterized by numerous osteoclast-like giant cells. However, these are not the actual tumor cells, but constitute a reactive infiltrate. Rather, the tumor cells are mononuclear mesenchymal cells, which even reveal an osteoblastic line of differentiation. Read More

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http://dx.doi.org/10.1007/s00292-020-00760-5DOI Listing

[Expression of H3.3 G34W mutant-specific antibody in giant cell tumors of bone and its diagnostic value].

Zhonghua Bing Li Xue Za Zhi 2020 Feb;49(2):116-121

Department of Pathology, Medicine School of Nanjing University/Nanjing Jinling Hospital, Nanjing 210002, China.

To investigate the expression of H3.3 G34W mutant-specific antibody in giant cell tumors of bone (GCTB), and its value in the diagnosis of GCTB. Immunohistochemical (IHC) EnVision method was used to detect the expression of H3. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.02.003DOI Listing
February 2020

Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases.

Clin Imaging 2020 Jun 30;62:23-32. Epub 2020 Jan 30.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, United States of America.

Purpose: To describe the imaging, anatomic, and clinical features of a series of secondary aneurysmal bone cysts (ABC) and to ascertain their most commonly associated primary bone lesions.

Methods: Forty-nine cases of histopathologically proven secondary ABCs were retrospectively reviewed. Demographic data and clinical history were obtained. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.01.022DOI Listing

[Molecular pathology in the diagnosis of bone tumors: current concepts].

Pathologe 2020 Mar;41(2):106-115

Knochentumor-Referenzzentrum, Institut für Pathologie, Universitätsspital Basel, Universität Basel, Schönbeinstrasse 40, Basel, 4031, Schweiz.

The integrative evaluation of histology and corresponding imaging is essential for the classification of bone tumors. Until a few years ago, there were hardly any molecular markers that could be used for diagnostic purposes. However, exome- and genome-wide sequencing analyses have since uncovered a number of tumor-specific aberrations that can be very helpful in ambiguous cases. Read More

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http://dx.doi.org/10.1007/s00292-019-00746-yDOI Listing

Differential Diagnosis of Cartilaginous Lesions of Bone.

Arch Pathol Lab Med 2020 01;144(1):71-82

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

Context.—: Cartilaginous tumors represent one of the most common tumors of bone. Management of these tumors includes observation, curettage, and surgical excision or resection, depending on their locations and whether they are benign or malignant. Read More

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http://dx.doi.org/10.5858/arpa.2019-0441-RADOI Listing
January 2020

Immunohistochemical analysis of 36 cases of chondroblastomas: A single institutional experience.

Ann Diagn Pathol 2020 Feb 13;44:151440. Epub 2019 Dec 13.

Department of Surgical Oncology (Bone and Soft Tissues, DMG), Tata Memorial Centre, HBNI University, Parel, Mumbai 400012, India.

Chondroblastoma is a relatively uncommon, primary benign bone tumor, frequently identified in young individuals. Despite its classical radiologic and histopathological features, at times, it is fraught with a diagnostic challenge, especially differentiating it from a giant cell tumor of bone (GCTB); an osteosarcoma and a chondrosarcoma. Lately, few studies have shown the diagnostic utility of immunohistochemical (IHC) expression DOG1 antibody in chondroblastomas. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.151440DOI Listing
February 2020

Chondroblastoma of the patella with pathological fracture in an adolescent: a case report.

World J Surg Oncol 2019 Dec 12;17(1):218. Epub 2019 Dec 12.

Department of Orthopedics, People's Hospital of Deyang City, Taishan North Road 173#, Deyang, 618000, Sichuan Province, People's Republic of China.

Background: Chondroblastoma is a rare primary bone tumor of young people that generally occurs in the epiphyseal plate of long bones. To date, only 13 cases of patella with pathological fracture in chondroblastoma have been previously published.

Case Presentation: A 15-year-old male patient presented with acute pain in the left knee after an injury occurred while playing basketball. Read More

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http://dx.doi.org/10.1186/s12957-019-1760-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909653PMC
December 2019

Edema Surrounding Benign Tumors and Tumor-Like Lesions.

Biomed Res Int 2019 29;2019:8206913. Epub 2019 Oct 29.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Objective: To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases.

Methods: Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Read More

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http://dx.doi.org/10.1155/2019/8206913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874953PMC

Tenosynovial Giant Cell Tumor, Localized Type With Extensive Chondroid Metaplasia: A Case Report With Immunohistochemical and Molecular Genetic Analysis.

Int J Surg Pathol 2020 Jun 26;28(4):447-453. Epub 2019 Nov 26.

Shimane University, Izumo, Shimane, Japan.

Tenosynovial giant cell tumor (TSGCT) of localized type is a common disease occurring mostly in the hands. Diagnosis of this tumor is relatively easy to render with hematoxylin-eosin-stained sections as compared with that of TSGCT of diffuse type. However, very rare cases with chondroid metaplasia that have recently been reported mainly in diffuse type can make pathological differentiation from soft tissue cartilaginous tumors extremely difficult. Read More

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http://dx.doi.org/10.1177/1066896919889672DOI Listing

Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma.

Virchows Arch 2020 Mar 25;476(3):455-463. Epub 2019 Nov 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.

Osteoid osteoma and osteoblastoma are bone-forming tumors shown to harbor FOS (87%) and FOSB (3%) rearrangements. The aim was to evaluate the immunohistochemical expression of FOS and FOSB in these tumors in comparison to other bone tumors, to evaluate the influence of decalcification, and to correlate immunohistochemical findings with the underlying genetic alteration using fluorescence in situ hybridization (FISH). Immunohistochemistry using whole sections was performed on osteoid osteoma (n=23), osteoblastoma (n=22), osteoblastoma-like osteosarcoma (n=3), reactive (n=3), and proliferative (n=11) bone lesions. Read More

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http://dx.doi.org/10.1007/s00428-019-02684-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085481PMC
March 2020
2.651 Impact Factor

Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma.

Virchows Arch 2020 Jan 14;476(1):135-146. Epub 2019 Nov 14.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Recently, specific driver mutations were identified in chondroblastoma, giant cell tumour of bone and central cartilaginous tumours (specifically enchondroma and central chondrosarcoma), sharing the ability to induce genome-wide epigenetic alterations. In chondroblastoma and giant cell tumour of bone, the neoplastic mononuclear stromal-like cells frequently harbour specific point mutations in the genes encoding for histone H3.3 (H3F3A and H3F3B). Read More

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http://dx.doi.org/10.1007/s00428-019-02699-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968983PMC
January 2020
2.651 Impact Factor

Clinical and molecular characterization of primary sclerosing epithelioid fibrosarcoma of bone and review of the literature.

Genes Chromosomes Cancer 2020 04 15;59(4):217-224. Epub 2019 Nov 15.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Sclerosing epithelioid fibrosarcoma (SEF) is a rare sarcoma subtype characterized by monomorphic epithelioid cells embedded in a densely sclerotic collagenous matrix. The overwhelming majority of tumors arise in soft tissues; however, rare cases have been documented to occur primarily in bone. The hallmarks of soft tissue SEF include MUC4 immunoreactivity and the presence of an EWSR1-CREB3L1 fusion. Read More

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http://dx.doi.org/10.1002/gcc.22822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082133PMC
April 2020
4.041 Impact Factor

Eight-Year Follow-Up Using a Fresh Osteochondral Allograft for a Femoral Head Chondroblastoma in a 17-Year-Old Patient.

Case Rep Orthop 2019 9;2019:9262190. Epub 2019 Sep 9.

Faculty of Medicine, Department of Surgery, Division of Orthopaedic Surgery, QC, Quebec, Canada.

Chondroblastoma is a rare benign tumor that affects the epiphysis of long bones in adolescents. Chondroblastoma located in the femoral head is associated with a higher recurrence rate and carries the additional risks of head collapse and degenerative hip disease. Aggressive curettage followed by bone grafting is the current mainstay of treatment. Read More

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http://dx.doi.org/10.1155/2019/9262190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754929PMC
September 2019
2 Reads

Anatomical Reconstruction of the Acromion Using an Autologous Iliac Crest Graft for Treatment of Recurrent Chondroblastoma: A Case Report.

JBJS Case Connect 2019 Jul-Sep;9(3):e0086

Department of Orthopaedics and Trauma Surgery, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Germany.

Case: A 38-year-old man presented with recurrent chondroblastoma of the acromion after primary curettage and bone grafting. The patient underwent revision surgery with resection of the acromion and reconstruction using an autologous iliac crest graft. He had regained normal shoulder function without recurrence at a follow-up of 17 months. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00086DOI Listing
June 2020
1 Read

Secondary Aneurysmal Bone Cyst of Base of Skull Associated with Chondroblastoma.

J Coll Physicians Surg Pak 2019 09;29(9):906

Department of Neurosurgery, Peoples University of Medical and Health Sciences, Nawabshah, Pakistan.

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http://dx.doi.org/10.29271/jcpsp.2019.09.906DOI Listing
September 2019
2 Reads

Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histological features and skeletal distribution.

Histopathology 2020 Jan 26;76(2):308-317. Epub 2019 Nov 26.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Aims: Chondroblastomas (CB) are rare bone tumours that typically arise in the epiphysis/apophysis of long bones in skeletally immature patients. We explore the clinicopathological features of CB presenting in adults.

Methods And Results: CB in patients ≥20 years of age were retrieved from our institutional archives. Read More

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http://dx.doi.org/10.1111/his.13972DOI Listing
January 2020
4 Reads

Chondroblastoma in pelvis and extremities- a signle centre study of 177 cases.

J Bone Oncol 2019 Aug 27;17:100248. Epub 2019 Jun 27.

Oncology Department, Royal Orthopaedic Hospital, Bristol Road, Birmingham B31 2AP, UK.

Introduction: Chondroblastoma is a rare benign bone tumour that usually occurs in children and young adults. They are cartilaginous tumours arising in the epiphysis or apophysis of a long bone. The tumour is classified as benign, although rare cases of pulmonary metastases have been reported. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695276PMC
August 2019
3 Reads

[Challenges in the diagnosis of cartilage tumors : Morphological spectrum and molecular markers].

Orthopade 2019 Sep;48(9):735-743

Sektion für Translationale Pathologie, Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, D17, 48149, Münster, Deutschland.

The morphological and clinico-biological spectrum of chondrogenic tumours is wide. Given the diversity of therapeutic approaches, the correctness of the histological diagnosis is of major importance. The aim of this review is to provide insights into the challenges and limitations of diagnostic approaches restricted to morphology and to underscore the importance of an interdisciplinary dialogue between surgeons, radiologists and pathologists. Read More

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http://dx.doi.org/10.1007/s00132-019-03787-6DOI Listing
September 2019
1 Read

Chondroblastoma-like Osteosarcoma.

Arch Pathol Lab Med 2020 01 7;144(1):15-17. Epub 2019 Aug 7.

From the Departments of Pathology (Drs Al Hmada, Bernieh, Lewin, and Allen), and Radiology (Dr Morris), University of Mississippi Medical Center, Jackson.

Context.—: Chondroblastoma-like osteosarcoma is an exceedingly rare variant of osteosarcoma, with 22 cases reported in the English-language literature. The tumor is slightly more common in males, with a broad age range (from childhood to elderly). Read More

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http://dx.doi.org/10.5858/arpa.2019-0191-RADOI Listing
January 2020
5 Reads

Distal Tibial Chondroblastoma With Intra-articular Penetration Treated With Gelatin Foam Sponge and Bone Grafting.

Orthopedics 2019 Jul;42(4):e391-e394

A 14-year-old boy presented with sharp left ankle pain for 1.5 years. Evaluation showed an irregular lytic lesion with surrounding sclerosis (diameter, 1. Read More

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http://dx.doi.org/10.3928/01477447-20190624-06DOI Listing
July 2019
3 Reads

Surgical treatment of chondroblastoma using extended intralesional curettage with phenol as a local adjuvant.

J Orthop Surg (Hong Kong) 2019 Sep-Dec;27(3):2309499019861031

1 Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.

Purpose: The aim of this study is to report the clinical and radiological outcomes following surgical treatment of chondroblastoma by means of an extended intralesional curettage using high-speed burr, with phenol as a local adjuvant which is followed by the implantation of synthetic bone graft, aiming to lower the recurrence rate of this tumor.

Patients And Methods: This retrospective study included 20 patients with chondroblastoma lesions during the period between 2000 and 2015.

Results: Fifteen males and five females were followed up for a mean of 63. Read More

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http://journals.sagepub.com/doi/10.1177/2309499019861031
Publisher Site
http://dx.doi.org/10.1177/2309499019861031DOI Listing
June 2020
10 Reads

Test yourself: question and answer question: painful knee swelling.

Skeletal Radiol 2019 11;48(11):1811-1814

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave., JMH WW 279, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s00256-019-03273-2DOI Listing
November 2019

Have the difficulties and complications of surgical treatment for chondroblastoma of the adjoining knee joint been overestimated?

J Bone Oncol 2019 Aug 13;17:100240. Epub 2019 May 13.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Background And Objective: Chondroblastoma is difficult to treat as the tumor is surrounded by both articular cartilage and the epiphyseal plate. The differences in joint shape further complicate the problem. This retrospective study evaluates the efficacy of intraregional aggressive curettage and allogeneic bone grafting for treating chondroblastoma of the adjoining knee joint. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535629PMC
August 2019
10 Reads

Modified trapdoor procedures by surgical dislocation approach to treat chondroblastoma of the femoral head.

Bone Joint J 2019 Jun;101-B(6):732-738

Central South University, Xiangya Hospital, Department of Orthopaedics, Changsha, China.

Aims: The aim of this study was to evaluate the efficacy of the surgical dislocation approach and modified trapdoor procedure for the treatment of chondroblastoma of the femoral head.

Patients And Methods: A total of 17 patients (ten boys, seven girls; mean age 16.4 years (11 to 26)) diagnosed with chondroblastoma of the femoral head who underwent surgical dislocation of the hip joint, modified trapdoor procedure, curettage, and bone grafting were enrolled in this study and were followed-up for a mean of 35. Read More

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http://dx.doi.org/10.1302/0301-620X.101B6.BJJ-2018-1599.R1DOI Listing
June 2019
18 Reads

Chondroblastoma-like mass of the temporal bone, secondary aneurysmal bone cyst, and intracerebral hemorrhage in a patient with cardiofaciocutaneous syndrome: case report.

J Neurosurg Pediatr 2019 May 24:1-6. Epub 2019 May 24.

Departments of1Neurosurgery.

Cardiofaciocutaneous syndrome (CFCS) is a rare developmental disorder that is phenotypically similar to Noonan syndrome and is associated with mutations in BRAF, MEK1, MEK2, and KRAS. The relationship between malignancy risk and CFCS is unclear with few cases published in the literature. The purpose of this paper is to describe the case of a patient with CFCS presenting in extremis as a result of a large intracerebral hemorrhage arising from a temporal bone mass with histopathology most consistent with chondroblastoma and secondary aneurysmal bone cyst. Read More

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http://dx.doi.org/10.3171/2019.3.PEDS18607DOI Listing
May 2019
11 Reads

Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer.

Cancers (Basel) 2019 May 13;11(5). Epub 2019 May 13.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38112, USA.

In this review, we describe the attributes of histone H3 mutants identified in cancer. H3 mutants were first identified in genes encoding H3.3, in pediatric high-grade glioma, and subsequently in chondrosarcomas and giant cell tumors of bone (GCTB) in adolescents. Read More

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http://dx.doi.org/10.3390/cancers11050660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562757PMC
May 2019
5 Reads

Genetic profiling of a chondroblastoma-like osteosarcoma/malignant phosphaturic mesenchymal tumor of bone reveals a homozygous deletion of CDKN2A, intragenic deletion of DMD, and a targetable FN1-FGFR1 gene fusion.

Genes Chromosomes Cancer 2019 10 15;58(10):731-736. Epub 2019 May 15.

Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden.

Conventional osteosarcoma is the most common primary malignancy of bone. This group of neoplasms is subclassified according to specific histological features, but hitherto there has been no correlation between subtype, treatment, and prognosis. By in-depth genetic analyses of a chondroblastoma-like osteosarcoma, we detect a genetic profile that is distinct from those previously reported in benign and malignant bone tumors. Read More

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http://dx.doi.org/10.1002/gcc.22764DOI Listing
October 2019
15 Reads

Chondroblastoma-like primary malignant giant cell tumor of the humerus - a case report.

Cesk Patol 2019 ;55(1):42-47

35-year-old woman suffered prolonged pain in the left shoulder, where an aggressively growing tumor of the proximal humerus was revealed thereafter. The lesion caused massive osteolysis of the metaepiphysis with cortical disruption, but no soft tissue extension was evident. Given the unsatisfactory effect, the ongoing neoadjuvant chemotherapy was prematurely ceased and the resection 13 cm long segment of bone with modular prosthesis replacement followed. Read More

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June 2019
26 Reads

Functional and Oncological Outcome After Treatment of Chondroblastoma With Intralesional Curettage.

J Pediatr Orthop 2019 Apr;39(4):e312-e317

Orthopedic Surgery Department, Faculty of Medicine, Menoufia University, Egypt.

Background: Chondroblastoma is a rare cartilaginous benign bone tumor that commonly arises in long bones of young people. Surgical management is the primary treatment of choice for chondroblastoma and it entails adequate intralesional curettage alone or in combination with adjuvants. This study was performed to describe the epidemiological characteristics and clinical and radiologic results of intralesional curettage of chondroblastoma. Read More

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http://Insights.ovid.com/crossref?an=01241398-201904000-0002
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http://dx.doi.org/10.1097/BPO.0000000000001293DOI Listing
April 2019
9 Reads
1.426 Impact Factor

Diffuse Tenosynovial Giant Cell Tumor Around the Temporomandibular Joint: An Entity With Special Radiologic and Pathologic Features.

J Oral Maxillofac Surg 2019 May 29;77(5):1022.e1-1022.e39. Epub 2019 Jan 29.

Professor, Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Purpose: Diffuse tenosynovial giant cell tumor (TGCT) of the temporomandibular joint (TMJ) is rare. The aim of the present study was to summarize the clinical, radiologic, and pathologic features of this tumor.

Materials And Methods: Nine cases of TGCT in the TMJ region were examined. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.025DOI Listing
May 2019
9 Reads

Chondroblastoma Of The Lumbar Vertebra.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):608-610

Department of Radiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Chondroblastoma is an uncommon and benign bone tumour. No more than 10 cases of lumbar chondroblastoma have been reported in the past 20 years. To describe the clinical presentations and radiological features of a rare case of chondroblastoma of the lumbar spine, this study reports one case involving the third lumbar vertebrae. Read More

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February 2019
36 Reads

Vascularized Bone Autograft for the Treatment of Chondroblastoma of the Talus at Imminent Risk of Joint Breakdown: Three Case Reports.

J Foot Ankle Surg 2019 Mar 3;58(2):363-367. Epub 2019 Jan 3.

Professor, Associate Professor, and Chair, Clinic of Orthopaedic Surgery, Kantonsspital Baselland, Liestal, Switzerland.

Surgical treatment options in a chondroblastoma of the talus breaching the subchondral layer with imminent risk of talar collapse in the weightbearing area are limited. A joint-preserving surgery should be advocated. Because current treatment options such as curettage, cryosurgery, or radiofrequency ablation may not be able to prevent a talar dome breakdown in large defects, nonvascularized bone grafting has been advocated to fill the void. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10672516183039
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http://dx.doi.org/10.1053/j.jfas.2018.08.053DOI Listing
March 2019
28 Reads

Diagnosis and Literature Review of Chondromyxoid Fibroma - A Pathological Puzzle.

J Orthop Case Rep 2019 ;9(4):101-105

Department of Orthopaedics and Traumatology, Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.

Introduction: Chondromyxoid fibroma (CMF) is a benign rare bone tumor of slow-growing nature arising from chondroblastic derivation. CMF in most of the cases is a diagnosis of exclusion, and in this case report, we differentiate the histological and radiological findings of CMF and difficulties in diagnosis of CMF from potential differential diagnosis.

Case Report: A 38-year-old female patient presented with a history of limping for 5 months and on evaluation revealed an expansile osteolytic lesion in fibular head with septations and soft tissue component. Read More

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http://dx.doi.org/10.13107/jocr.2019.v09.i04.1500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210904PMC
January 2019

Synovial Lipomatosis with Chondroblastoma in an 8-year-old Female: A Previously Unreported Entity.

J Orthop Case Rep 2019 ;9(4):22-25

Department of Orthopedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, New Delhi, India.

Introduction: Synovial lipomatosis is a rare disease entity and a very small number of cases have been reported so far. It is characterized by villous proliferation of the synovium with expansion by mature adipose tissue. The etiology is unclear, thought cases can be seen secondary to injury, inflammation, chronic degenerative changes and neoplasms. Read More

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http://dx.doi.org/10.13107/jocr.2019.v09.i04.1462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210901PMC
January 2019

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing.

Genes Chromosomes Cancer 2019 02 24;58(2):88-99. Epub 2018 Dec 24.

Department of Pathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom.

The last decade has seen the majority of primary bone tumor subtypes become defined by molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p. Read More

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http://doi.wiley.com/10.1002/gcc.22699
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http://dx.doi.org/10.1002/gcc.22699DOI Listing
February 2019
15 Reads