1,494 results match your criteria Chondroblastoma

Approach to Primary Vertebral Tumors in the Light of the 2020 Updated World Health Organization Classification of Bone Tumors.

Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Umraniye Education and Research Hospital, Department of Pathology, Istanbul, Turkey.

Aim: The spinal canal frequently harbors primary and secondary bone tumors. These tumors have specific localization, age range, and clinical and radiological manifestations, and their treatment requires a multidisciplinary approach. In most cases, a definitive diagnosis is made based on clinical, radiological, and histopathological findings. Read More

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December 2021

A report of an intracortical chondroblastoma of the diaphysis in a skeletally mature patient.

Skeletal Radiol 2022 Jun 16. Epub 2022 Jun 16.

Department of Orthopedic Surgery, University of Missouri, Columbia, USA.

Chondroblastomas characteristically occur in skeletally immature patients, and arise within the medullary canal of the epiphysis. We report a rare case of an intracortical chondroblastoma arising in the diaphysis, and occurring in an adult in his 3 decade of life. Immunohistochemistry results were critical to confirmation of this rare diagnosis, with immunohistochemistry showing S100, DOG1, and H3K36me3 positivity in the neoplastic cells. Read More

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Primary and Metastatic Bone Tumors of the Patella: Literature Review and Institutional Experience.

Arch Bone Jt Surg 2022 Feb;10(2):190-203

Department of Orthopaedic Oncology Harvard Medical School, Massachusetts General Hospital Boston MA, USA.

Background: Patellar tumors are rare but certainly must be considered in the differential diagnosis in patients with knee pain. Diagnosis can be challenging as often patellar neoplasms are confused with benign conditions and their clinical presentation is usually not specific. We performed an institutional and a literature review to determine what are the most common tumors affecting the patella and what is the best management. Read More

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February 2022

GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.

Am J Surg Pathol 2022 Jun 1. Epub 2022 Jun 1.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that manifests histologically as a lobular proliferation of stellate to spindle-shaped cells in a myxoid background, exhibiting morphologic overlap with other cartilaginous and myxoid tumors of bone. CMF is characterized by recurrent genetic rearrangements that place the glutamate receptor gene GRM1 under the regulatory control of a constitutively active promoter, leading to increased gene expression. Here, we explore the diagnostic utility of GRM1 immunohistochemistry as a surrogate marker for GRM1 rearrangement using a commercially available monoclonal antibody in a study of 230 tumors, including 30 CMF cases represented by 35 specimens. Read More

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Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.

Virchows Arch 2022 May 25. Epub 2022 May 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the RAS/MAPK pathway. However, NOF is located in the long bones with regression after puberty in contrast to CGCG which is located in the jaw bones and does not regress spontaneously. We hypothesised that endocrine regulation by oestrogen plays a role in the spontaneous regression in NOF. Read More

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Arthroscopic management of Juxta-articular chondroblastoma with bone substitutes - A case report.

J Clin Orthop Trauma 2022 Jun 11;29:101895. Epub 2022 May 11.

Department of Orthopaedic Surgery, Father Muller Medical College, Mangalore, 575002, India.

Chondroblastoma, a rare benign bone tumour arising from the epiphysis, accounts for approximately 1% of all primary bone tumours and is known to be locally aggressive with potential for metastases and local recurrence. Open surgical curettage is associated with high risk of recurrence and potential for damage to the physis resulting in growth disturbances. We report a 14-year-old girl with chondroblastoma involving the distal femoral epiphysis in whom an arthroscopic approach was employed for thorough curettage of the lesion under direct vision followed by cavity management using bone graft substitute. Read More

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[Giant-cell tumor of bone in 2022].

Ann Pathol 2022 Apr 3;42(3):214-226. Epub 2022 May 3.

Service de pathologie, hôpital Trousseau, CHRU de Tours, Tours, France; Université de Tours, Tours, France.

Giant cell tumors of bone (GCTs) are rare mesenchymal tumors classified as intermediate in the WHO 2020 classification, i.e. neither completely benign nor definitely malignant, due to recurrence (frequent) and pulmonary metastases (rare). Read More

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Treatment of locally aggressive benign bone tumors by means of extended intralesional curettage without chemical adjuvants.

SAGE Open Med 2022 22;10:20503121221094199. Epub 2022 Apr 22.

Department of Orthopedics and Traumatology, Marmara University Pendik Training and Research Hospital, İstanbul, Turkey.

Objectives: The aim of this study is to present the clinical, oncological, and functional results of locally aggressive benign bone tumors treated with extended intralesional curettage without the use of adjuvant in a tertiary orthopedic oncology center.

Method: A total of 172 patients treated with surgical curettage and high-speed burrs for the diagnosis of aneurysmal bone cyst, giant cell tumor, osteoblastoma, chondroblastoma, and chondromyxoid fibroma were included in the study. Demographic, radiological, and clinical data of the patients were analyzed. Read More

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Chondroblastoma of the Occipital Bone With Atypical Genetic Markers: A Case Report.

Cureus 2022 Feb 21;14(2):e22451. Epub 2022 Feb 21.

Department of Neurological Surgery, University of Washington, Seattle, USA.

Chondroblastoma is a rare bone tumor, most often found in epiphyseal plates of long bones. It has infrequently been reported in the skull, most often in the temporal bone. We present a case of chondroblastoma of the occipital bone in a pediatric patient presenting with a bony protuberance of the occiput and imaging consistent with obstructive hydrocephalus, which persisted even after removal of the obstructing tumor. Read More

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February 2022

Letter to the Editor Regarding "Functional Prognosis Following Temporal Bone Chondroblastoma Resection: A Systematic Review and Case Illustration".

Keyi Guo Yufei Li

World Neurosurg 2022 Apr;160:118

School of Medicine and Department of Surgery, School of Medicine, Hunan Normal University, Changsha, Hunan, China. Electronic address:

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Complex Reconstruction for Acetabular Pathologic Fracture in Unusual Chondroblastoma With Aneurysmal Bone Cyst.

Arthroplast Today 2022 Apr 28;14:65-70. Epub 2022 Feb 28.

Department of Orthopaedic Surgery and Sports Medicine, University of Florida, Gainesville, FL, USA.

Treating bone loss with complex arthroplasty poses a significant challenge for the arthroplasty surgeon. When considering a reconstructive case after pathologic fracture and oncologic excision, a multidisciplinary approach with reliance on arthroplasty principles is critical. An 18-year-old patient presented with a complex acetabular pathologic fracture through a chondroblastoma with a secondary aneurysmal bone cyst. Read More

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Management of Primary Aggressive Tumors of the Knee.

J Knee Surg 2022 May 18;35(6):585-596. Epub 2022 Feb 18.

The Center for Orthopedic Research and Eduction (CORE) Institute, Phoenix, Arizona.

Primary bone sarcomas and aggressive benign bone tumors are relatively rare. It is essential to recognize features that are concerning for these aggressive tumors based on a patient's history, physical exam, and radiographs. Physicians and other health care providers should have a high suspicion for these tumors and promptly refer these patients to orthopaedic oncologists. Read More

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5-ALA-mediated fluorescence of musculoskeletal tumors in a chick chorio-allantoic membrane model: preclinical in vivo qualification analysis as a fluorescence-guided surgery agent in Orthopedic Oncology.

J Orthop Surg Res 2022 Jan 15;17(1):34. Epub 2022 Jan 15.

Department of Orthopedic Oncology, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) and other contrast agents has shown its efficacy in improving resection margins, local recurrence and survival rates in several medical disciplines. It is the objective of this study to analyze the engraftment rate of musculoskeletal tumor specimens on the chick chorio-allantoic membrane (CAM), the rate of tumor fluorescence (PDD), and the effects of photodynamic therapy (PDT) after exposure of tumors to 5-ALA in an in vivo environment.

Methods: A total of 486 CAMs were inoculated with macroscopic tumor grafts (n = 26; n = 478 eggs) and primary cell culture suspensions (n = 2; n = 8 eggs) from 26 patients on day 10 of egg development. Read More

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January 2022

Imaging features of cartilaginous tumors of the head and neck.

J Clin Imaging Sci 2021 4;11:66. Epub 2021 Dec 4.

Department of Radiology, Mayo Clinic Arizona, Phoenix, Arizona, United States.

There is a wide spectrum of head and neck cartilaginous lesions which include both neoplastic and nonneoplastic processes. Cartilaginous tumors of the head and neck are uncommon, posing a diagnostic challenge. Benign cartilaginous tumors that may occur in the head and neck include chondroma, chondroblastoma, chondromyxoid fibroma, osteochondroma, and synovial chondromatosis. Read More

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December 2021

Chondroblastic Osteosarcoma of the Mandible in a Patient on Risedronate: A Rare Case of Neoadjuvant Chemotherapy Failure.

Cureus 2021 Nov 26;13(11):e19929. Epub 2021 Nov 26.

Oral and Maxillofacial Surgery, Centre Hospitalier Intercommunal de Villeneuve Saint-Georges, Villeneuve Saint-Georges, FRA.

Osteosarcoma of the jaw only represents 0.5-1% of tumors of the facial mass. Due to its rarity, clinical diagnosis is thus difficult. Read More

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November 2021

Chondroblastoma-Like Soft-Tissue Chondroma of the Hand: A Case Report.

Ali H AlYami

Cureus 2021 Nov 11;13(11):e19467. Epub 2021 Nov 11.

Department of Surgery, Ministry of the National Guard - Health Affairs, Jeddah, SAU.

We present a case of chondroblastoma-like chondroma (CLC) of soft tissue that manifested as a palmar mass on the left hand of an 84-year-old man. Physical examination, imaging investigation, and needle biopsy initially suggested a giant cell tumor of the tendon sheath, until a correct diagnosis was made based on excised specimen histology. The patient underwent a marginal excision for soft-tissue mass removal. Read More

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November 2021

A Case of Arthroscopic Treatment of Chondroblastoma-Induced Chondropathy Situated at the Posterior Talus.

J Am Podiatr Med Assoc 2021 Sep;111(5)

Chondroblastoma located in the talus is a rare incidence, and due to the weightbearing duty of the talus, the results of local excision may not be favorable. While the volume of the tumor increases, more sophisticated techniques may be undertaken. Cell-free matrix application for extensive osteochondral defects is gaining popularity for its structural support when it is used with microfracture and autograft application. Read More

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September 2021

Surgical hip dislocation for treatment of femoral head chondroblastoma: efficacy and safety.

Int Orthop 2022 03 19;46(3):653-660. Epub 2021 Nov 19.

Department of Orthopaedics and Traumatology, Kasralainy School of Medicine, Cairo University, Cairo, Egypt.

Purpose: Femoral head chondroblastoma poses a surgical challenge. Anatomical limitations may lead to increased risk of local recurrence, damage to the articular cartilage, growth disturbances, and/or avascular necrosis (AVN). We are presenting our results with surgical hip dislocation approach with the aim to evaluate its efficacy in preventing recurrence and its safety, preserving a functional hip joint and avoiding complications. Read More

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Gene of the month: H3F3A and H3F3B.

J Clin Pathol 2022 Jan 15;75(1):1-4. Epub 2021 Nov 15.

Division of Anatomical Pathology, University of Cape Town, Cape Town, South Africa.

and genes are located at 1q42.12 and 17q25.1, respectively, and encode identical H3. Read More

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January 2022

Chondroblastoma of the Temporal Bone: A Case Report and Literature Review.

Acta Medica (Hradec Kralove) 2021 ;64(3):170-173

The Jessenius Medical Faculty of Comenius University in Martin, Slovakia.

Introduction: Temporal bone chondroblastoma is a rare, locally aggressive tumour originating from immature cartilage, which recurs to a high degree. Treatment is surgical. Radiotherapy is reserved for recurrence. Read More

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November 2021

Benign Cartilage-forming Tumors.

Surg Pathol Clin 2021 Dec 7;14(4):585-603. Epub 2021 Oct 7.

Department of Pathology, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA. Electronic address: https://twitter.com/nicolecipriani.

Although uncommon in many pathology practices, cartilage-forming tumors represent some of the most frequent primary bone tumors. Diagnosis can be challenging given their variable histologic spectrum and the presence of overlapping morphologic, immunohistochemical, and genetic features between benign and malignant entities, particularly low-grade malignancies. Correlation with clinical findings and radiographic features is crucial for achieving an accurate diagnosis and appropriate clinical management, ranging from observation to excision. Read More

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December 2021

Functional Prognosis Following Temporal Bone Chondroblastoma Resection: A Systematic Review and Case Illustration.

World Neurosurg 2021 Nov 1. Epub 2021 Nov 1.

Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Background: Chondroblastomas are rare tumors that account for <1% of all bone tumors, and 5.7% of them occur in the skull. The aim of this study was to investigate factors related to their functional prognosis by conducting a systematic review, including our own case. Read More

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November 2021

Chondroblastoma of the knee in a teenager.

Radiol Case Rep 2021 Dec 2;16(12):3729-3733. Epub 2021 Oct 2.

Department of Radiology, NYC Health + Hospital / Harlem, New York, USA.

Chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumors. Characteristically it arises in the epiphysis or apophysis of long bones in young patients and may extend into the metaphysis. A sixteen-year-old male presents with a 1-year history of left knee pain associated with joint stiffness and interfering with performing daily activities. Read More

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December 2021

Infratemporal Fossa Chondroblastoma.

J Craniofac Surg 2021 Oct 8. Epub 2021 Oct 8.

Faculty of Medicine, University of Belgrade, Clinical Centre of Serbia, Clinic for Otorhinolaryngology and Maxillofacial Surgery Faculty of Medicine, University of Belgrade, Institute of Pathology Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Introduction: Chondroblastoma is a rare, benign mesenchymal tumor that can behave local aggressive. It most often occurs in the area of the epiphyses of long tubular bones, whereas the appearance in the region of the head and neck is rare, only few reports were published in literature. The incidence of chondroblastoma of the craniofacial region is about 6. Read More

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October 2021

Chondroblastoma in the Children Treated with Intralesional Curettage and Bone Grafting: Outcomes and Risk Factors for Local Recurrence.

Orthop Surg 2021 Oct 2;13(7):2102-2110. Epub 2021 Oct 2.

Department of Pediatric Orthopaedics, Beijing Jishuitan Hospital, Peking University, Beijing, China.

Objective: To review the outcomes of surgical management in the pediatric patients with extremity chondroblastoma. Especially the risk factors of recurrence and growth disorder. And discuss a potential method to decrease the rate of growth disorder by preventing the premature physeal closure. Read More

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October 2021

Chondroblastoma of mandibular condyle: Case report and literature review.

Open Med (Wars) 2021 13;16(1):1372-1377. Epub 2021 Sep 13.

Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.

Chondroblastoma is one of the uncommon benign bone tumors, particularly when located in the mandibular condyle. Such a location makes its diagnosis difficult when based on only its clinical presentation and radiographic features. Herein the current report presents a case of chondroblastoma of the mandibular condyle: its clinical presentation, radiographic features, and immediate condylar reconstruction after resection. Read More

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September 2021

Chondroblastoma treatment by radiofrequency thermal ablation: Initial experience and implementation.

Eur J Radiol 2021 Nov 17;144:109950. Epub 2021 Sep 17.

Department of Radiology and Physical Medicine, Hospital Virgen de las Nieves, University of Granada, Spain.

Purpose: To present our experience on the implementation of radiofrequency thermal ablation (RFA) for the treatment of chondroblastoma.

Materials And Methods: This case series includes 12 patients (10 males) with chondroblastoma using RFA under CT guidance. Tumours were located in the humeral head (3), femoral head (2), distal femoral epiphysis (4), tibial epiphysis (2) and calcaneus (1). Read More

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November 2021

Tumors and pseudotumors of foot and ankle: Bone lesions.

Foot (Edinb) 2021 Dec 29;49:101845. Epub 2021 Jun 29.

Radiology & Orthopeadic Surgery, UT Southwestern, 5323 Harry Hines Blvd, Dallas, TX, United States. Electronic address:

Bone tumors and tumor-like lesions (pseudotumors) are not uncommonly encountered as asymptomatic findings on imaging, or as symptomatic lesions clinically. Radiographic imaging is the first diagnostic tool for their management strategy, since the symptoms are commonly non-specific, such as pain, swelling, and redness. Image findings must be analyzed with attention to the specific features such as lesion location, margination, zone of transition, mineralization, size and multifocality, soft tissue component and/or loco-regional extent. Read More

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December 2021