1,680 results match your criteria Cholesterol Embolism

Controlling Nutritional Status (CONUT) score predicts in-hospital mortality in acute pulmonary embolism.

Med Princ Pract 2022 May 25. Epub 2022 May 25.

Objective: This is the first study examining the value of CONUT score in assessing malnutrition among acute pulmonary embolism patients. We showed that the presence of malnutrition defined by the CONUT score predicts in-hospital mortality following acute pulmonary embolism.The association between the nutritional status and outcomes in pulmonary embolism is unclear. Read More

View Article and Full-Text PDF

Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research - 20 years of experience and future perspectives.

Semin Immunol 2022 May 12:101604. Epub 2022 May 12.

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The complex molecular and cellular biological systems that maintain host homeostasis undergo continuous crosstalk. Complement, a component of innate immunity, is one such system. Initially regarded as a system to protect the host from infection, complement has more recently been shown to have numerous other functions, including involvement in embryonic development, tissue modeling, and repair. Read More

View Article and Full-Text PDF

A case of cholesterol embolization syndrome mimicking rapidly progressive renal failure causing end-stage kidney disease.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1489-1494

Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Cholesterol embolization syndrome is an uncommon complication of coronary angioplasty. Its clinical manifestations are nonspecific and may be ascribed to other causes mimicking vasculitis syndrome. In an appropriate clinical setting, the diagnosis can be confirmed by tissue biopsy. Read More

View Article and Full-Text PDF

Developing a Nomogram-Based Scoring Tool to Estimate the Risk of Pulmonary Embolism.

Int J Gen Med 2022 5;15:3687-3697. Epub 2022 Apr 5.

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, People's Republic of China.

Background: Pulmonary embolisms (PEs) are clinically challenging because of their high morbidity and mortality. This study aimed to develop a scoring tool for predicting PEs to improve their clinical management.

Methods: Clinical, laboratory, and imaging parameters were retrospectively collected from suspected PE patients who had cough or chest pain and were hospitalized in West China Hospital of Sichuan University from May 2015 to April 2020. Read More

View Article and Full-Text PDF

Cholesterol Embolization Syndrome after Carotid-Artery Stenting.

Wei Wang Jifu Cai

N Engl J Med 2022 03;386(13):1265

University of Hong Kong-Shenzhen Hospital, Shenzhen, China

View Article and Full-Text PDF

Incidence, Risk Factors, and Prognosis of Cholesterol Crystal Embolism Because of Percutaneous Coronary Intervention.

Am J Cardiol 2022 03 2;167:15-19. Epub 2022 Jan 2.

Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan.

Cholesterol crystal embolism (CCE) is a rare but serious complication of percutaneous coronary intervention (PCI). However, its incidence, risk factors, and prognosis in the contemporary era are not well known. We included 23,184 patients who underwent PCI in our institution between January 2000 and December 2019 in this study. Read More

View Article and Full-Text PDF

Cholesterol crystal embolism-related cerebral infarction: Magnetic resonance imaging and clinical characteristics.

eNeurologicalSci 2021 Dec 8;25:100388. Epub 2021 Dec 8.

Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.

Background And Aims: Cholesterol crystal embolism-related cerebral infarction (CCE-CI) is frequently misdiagnosed due to the lack of specific symptoms. To aid in differential diagnosis, this study comprehensively characterized the magnetic resonance imaging (MRI) and clinical manifestations of CCE-CI and compared these features to those of atherothrombotic cerebral infarction (ACI).

Methods: This single-center, retrospective, observational study was conducted at Kitasato University Hospital, Kanagawa, Japan. Read More

View Article and Full-Text PDF
December 2021

Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial.

J Thromb Haemost 2022 04 8;20(4):877-887. Epub 2022 Jan 8.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Background: Venous thromboembolism (VTE) is a frequent cardiovascular disease with severe complications, including recurrence and death. There is a great need for alternative prophylactic treatment options as anticoagulation is accompanied by increased bleeding risk. Statins are reported to reduce the risk of incident and recurrent VTE, but the mechanisms are elusive. Read More

View Article and Full-Text PDF

Effect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits.

Bioengineered 2021 12;12(2):12535-12543

Department of Vascular Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Liaoning Province.

The study was to explore the effect of subintimal angioplasty (SIA) on the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular endothelial cadherin (VE-cadherin) in the rabbit model of lower extremity arterial occlusion. Specifically, the poly(N-isopropylacrylamide-co-butyl methacrylate) (PIB) temperature-sensitive nanogel was prepared, and the cytotoxicity of direct and indirect contact with PIB temperature-sensitive gel was analyzed then. Subsequently, the PIB temperature-sensitive gel was injected to the New Zealand white rabbit to prepare the lower extremity arterial occlusion model. Read More

View Article and Full-Text PDF
December 2021

Big mitral annular calcification: a case report of a dynamic liquefaction necrosis as a potential source of embolism.

Eur Heart J Case Rep 2021 Oct 24;5(10):ytab380. Epub 2021 Sep 24.

Department of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

Background: Mitral annular calcification (MAC) is a degenerative, mostly asymptomatic abnormality usually in elderly patients. Caseous MAC (cMAC) is a rare form with central liquefaction necrosis, which typically involves the posterior annulus of the mitral valve and can cause serious sequelae. However, optimal management of patients with cMAC is not clearly defined. Read More

View Article and Full-Text PDF
October 2021

[Atheroembolic renal disease: risk factors, diagnostics, histology, and therapeutic approaches].

G Ital Nefrol 2021 Oct 26;38(5). Epub 2021 Oct 26.

U.O.C di Nefrologia e Dialisi, A.O. per l'Emergenza "Cannizzaro", Catania, Italy.

The increase in patients' average age, the enhancement of anticoagulation therapy and the growth of vascular interventions represent the perfect conditions for the onset of atheroembolic renal disease. AERD is observed in patients with diffuse atherosclerosis, generally after a triggering event such as surgery on the aorta, invasive procedures (angiography, catheterization of the left ventricle, coronary angioplasty) and anticoagulant or fibrinolytic therapy. The clinical signs are heterogeneous, a consequence of the occlusion of downstream small arterial vessels by cholesterol emboli coming from atheromatous plaques of the aorta, or one of its main branches. Read More

View Article and Full-Text PDF
October 2021

Atrial cardiopathy predicts detection of atrial fibrillation in embolic stroke of undetermined source: real-life data.

Neurol Sci 2022 Apr 27;43(4):2383-2386. Epub 2021 Oct 27.

Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany.

Objectives: Atrial cardiopathy (AC) is more frequent in patients with embolic stroke of undetermined source (ESUS) than in patients with non-cardioembolic stroke. The aim of this work was to describe AC in patients with ESUS and to study its impact on detection of atrial fibrillation (AF) during follow-up.

Methods: This is an observational study of 123 consecutive ESUS patients and 55 ESUS patients from a previous cohort. Read More

View Article and Full-Text PDF

Effects of targeted community healthcare on the prevention of thrombotic adverse events in patients with coronary heart disease under the guidance of behavior change theory.

Am J Transl Res 2021 15;13(9):10703-10711. Epub 2021 Sep 15.

Department of Cardiovascular Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei Province, China.

Objective: To explore the effects of targeted community healthcare on the prevention of thrombotic adverse events in patients with coronary heart disease under the guidance of behavior change theory.

Methods: A total of 89 patients with coronary heart disease who were admitted to our hospital were selected prospectively as subjects and divided into a research group (n=45, receiving targeted community healthcare under the guidance of behavior change theory) and a control group (n=44, receiving regular community healthcare) using a random number table method. The treatment period was 6 months. Read More

View Article and Full-Text PDF
September 2021

Formation and Cellular Impact of Cholesterol Crystals in Health and Disease.

Adv Biol (Weinh) 2021 11 29;5(11):e2100638. Epub 2021 Sep 29.

Center for Cardiovascular Research, University of Hawaii, 651 Ilalo Street, Honolulu, HI, 96813, USA.

Cholesterol crystals (CCs) were first discovered in atherosclerotic plaque tissue in the early 1900 and have since been observed and implicated in many diseases and conditions, including myocardial infarction, abdominal aortic aneurism, kidney disease, ocular diseases, and even central nervous system anomalies. Despite the widespread involvement of CCs in many pathologies, the mechanisms involved in their formation and their role in various diseases are still not fully understood. Current knowledge concerning the formation of CCs, as well as the molecular pathways activated upon cellular exposure to CCs, will be explored in this review. Read More

View Article and Full-Text PDF
November 2021

Use of Proprotein Converse Subtilisin/Kexin Type 9 Inhibitor to Treat Cholesterol Crystal Embolisms after Catheterization: A Report of Three Cases.

Intern Med 2022 Mar 31;61(6):857-860. Epub 2021 Aug 31.

Department of Cardiology, Kokura Memorial Hospital, Japan.

Cholesterol crystal embolism (CCE) is a serious complication that occurs after cardiac and vascular procedures. CCE involves multiple organs, and the prognosis and renal function of patients is poor. Although the efficacy of steroid, statin, and low-density lipoprotein apheresis has been reported, no definitive treatment has been established. Read More

View Article and Full-Text PDF

[Analysis of factors associated with pulmonary embolism during pregnancy].

H Yang X Y Han

Zhonghua Yi Xue Za Zhi 2021 Jul;101(28):2238-2241

Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To investigate risk factors associated with pulmonary embolism in women during pregnancy or peripartum. Information of 7 pregnant women diagnosed pulmonary embolism (PE) were collected from January 2018 to December 2020 in Beijing Friendship Hospital. Four non-PE pregnant women as control group were matched with each patient by age, BMI and pregnancy complications during the same period. Read More

View Article and Full-Text PDF

Efficacy of LDL apheresis for the treatment of cholesterol crystal embolism: A prospective, controlled study.

Ther Apher Dial 2022 Apr 11;26(2):456-464. Epub 2021 Jul 11.

Department of Nephrology, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.

This study was performed to evaluate the efficacy and safety of LDL apheresis (LDL-A) for the treatment of cholesterol crystal embolism (CCE) after cardiovascular procedures. We conducted a prospective multicenter study of 34 patients with CCE and 15 historical control patients. The present participants underwent six sessions of LDL-A for 4 weeks and underwent medical therapy with corticosteroids and statins. Read More

View Article and Full-Text PDF

Genetically predicted body composition in relation to cardiometabolic traits: a Mendelian randomization study.

Eur J Epidemiol 2021 Nov 30;36(11):1157-1168. Epub 2021 Jun 30.

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute for Metabolic Diseases, and Human Phenome Institute, Fudan University, NO.180 Fenglin Road, Shanghai, 200032, China.

Fat mass and fat-free mass are found to be associated with different health outcomes in observational studies, but the underlying causality remains unclear. We aimed to investigate the causal relationships between body composition and cardiometabolic traits using a two-sample Mendelian randomization (MR) approach. Independent genetic variants associated with body fat mass, fat-free mass, and fat percentage in UK Biobank population were used as genetic instrumental variables, and their causal effects on circulatory diseases, type 2 diabetes, glycemic traits, and lipid fractions were estimated from large-scale genome-wide association studies (GWAS) in European populations. Read More

View Article and Full-Text PDF
November 2021

Cutaneous Cholesterol Embolization to the Lower Trunk: An Underrecognized Presentation.

Cutis 2021 Mar;107(3):E8-E9

Virginia Commonwealth University, Richmond. Dr. Brinster is from the Departments of Dermatology and Pathology; Dr. Levy is from the Department of Surgery, Division of Vascular Surgery; and Dr. Awadalla is from the Department of Dermatology.

View Article and Full-Text PDF

Delayed Onset of Retinal Embolism After Coronary Angioplasty.

J Invasive Cardiol 2021 06 6;33(6):E483. Epub 2021 May 6.

Servicio de Oftalmología, Hospital Clínico San Carlos, Calle profesor Martín Lagos s/n, Madrid, 28040, Spain.

Although rare, retinal artery cholesterol emboli (Hollenhorst plaques) post angioplasty can be a severe event that can cause irreversible visual disturbances, usually taking place during or following the procedure. However, as the number of procedures continues to increase, interventional radiologists or cardiologists who perform coronary catheterization should be cognizant of its possible delayed occurrence, as in the case presented herein. Read More

View Article and Full-Text PDF

Statin treatment and outcomes after embolic stroke of undetermined source.

Intern Emerg Med 2021 Aug 24;16(5):1261-1266. Epub 2021 Apr 24.

Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

The association of low-density lipoprotein cholesterol lowering with outcomes in embolic stroke of undetermined source (ESUS) patients is unclear. In these patients we aimed to assess the effect of statin on stroke recurrence, major adverse cardiovascular events (MACE) and death rates. Consecutive ESUS patients in the Athens Stroke Registry were prospectively followed-up to 10 years for stroke recurrence, MACE, and death. Read More

View Article and Full-Text PDF

Cutaneous Polymer-Coating Embolism After Endovascular Procedures: Report of Two Cases and a Literature Review.

Am J Dermatopathol 2021 Sep;43(9):662-666

Departments of Pathology.

Abstract: Different hydrophilic and hydrophobic polymers are used as lubricious coatings to reduce vascular traumas in minimally invasive percutaneous procedures. Although they are usually very safe, there is still a risk of serious complications in patients undergoing such procedures, mostly derived from the devices' coating detachment and systemic embolization. The lungs are the most common organ involved, followed by the central nervous system. Read More

View Article and Full-Text PDF
September 2021

Ischemic small bowel perforation caused by cholesterol crystal embolism following transcatheter arterial chemoembolization for recurrent hepatocellular carcinoma: a case report.

Surg Case Rep 2021 Feb 10;7(1):45. Epub 2021 Feb 10.

Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Background: Cholesterol crystal embolism (CCE) following transcatheter arterial chemoembolization (TACE) is rare.

Case Presentation: A 71-year-old man underwent TACE for recurrence of hepatocellular carcinoma (HCC). On postoperative day (POD) 5, he developed abdominal pain and fever. Read More

View Article and Full-Text PDF
February 2021

Blood biomarkers to detect new-onset atrial fibrillation and cardioembolism in ischemic stroke patients.

Heart Rhythm 2021 06 6;18(6):855-861. Epub 2021 Feb 6.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Neurology, University Medicine Cluster, National University Health System, Singapore. Electronic address:

Background: Accumulating data suggest blood biomarkers could inform stroke etiology.

Objective: The purpose of this study was to investigate the performance of multiple blood biomarkers in elucidating stroke etiology with a focus on new-onset atrial fibrillation (AF) and cardioembolism.

Methods: Between January and December 2017, information on clinical and laboratory parameters and stroke characteristics was prospectively collected from ischemic stroke patients recruited from the National University Hospital, Singapore. Read More

View Article and Full-Text PDF

Ischemic stroke and retinal artery occlusion after carotid aneurysm embolization.

Radiol Case Rep 2021 Mar 9;16(3):701-703. Epub 2021 Jan 9.

Hôpital Fondation Adolphe de Rothschild, 25, rue Manin, 75019 Paris, France.

We present the case of a 72-year-old male with a right carotid aneurysm incidentally discovered after an ischemic stroke. After management of the stroke, stent-assisted coil embolization was performed to treat the aneurysm. Two simultaneous and early complications occurred: new ischemic strokes and branch retinal artery occlusions, respectively in the right occipital lobe and in the right eye. Read More

View Article and Full-Text PDF

Spontaneous Cholesterol Crystal Embolism and Aortic Plaques.

Intern Med 2021 Jun 15;60(12):1981-1982. Epub 2021 Jan 15.

Division of Internal Medicine, Mitsui Memorial Hospital, Japan.

View Article and Full-Text PDF

Crystalopathy - underestimated entity in nephrology.

Vnitr Lek 2020 ;66(6):371-377

Crystal is a solid particle with a geometric shape because its atoms, ions, or molecules are arranged in a regular ordered structure. However, in case of accidental order of the particles, we are talking about the amorphous substances which can also form crystallike particles. Crystallopathy is a disease that involves crystals of crystallike particulate matter in the pathogenesis of tissue injury. Read More

View Article and Full-Text PDF
January 2021

The significance of Holter electrocardiography in the etiological evaluation of transient ischemic stroke.

Brain Circ 2020 Jul-Sep;6(3):191-195. Epub 2020 Sep 30.

Department of Neurology, Izmir Tepecik Education and Research Hospital, Izmir,, Turkey.

Background: Transient ischemic attack (TIA) is a common neurovascular disorder associated with a higher risk of stroke within the first 24 h after the first event. Acute cerebral and arterial neuroimaging combined with long-term electrocardiography (ECG) monitoring have been proven to be useful in determining etiology. Cardio-embolism constitutes 20%-26% etiology of TIAs most of them with atrial fibrillation (AF). Read More

View Article and Full-Text PDF
September 2020

Durvalumab-associated vasculitis presenting as 'the blue toe syndrome'.

BMJ Case Rep 2020 Nov 18;13(11). Epub 2020 Nov 18.

Internal Medicine, St John of Gods Hospital Midland, Perth, Western Australia, Australia.

Durvalumab is a selective, high-affinity human immunoglobulin monoclonal antibody in a class called check point inhibitors, that blocks PD-L1 on tumour cells. Despite clinical success in increasing progression-free survival rates in patients with stage III non-small-cell lung cancer, durvalumab has been associated with immune-related side effects such as pneumonitis and colitis. We present a case of an 84-year-old woman with acral vasculitis presenting as blue toe syndrome, associated with prolonged use of durvalumab. Read More

View Article and Full-Text PDF
November 2020

Mimics of vasculitis.

Rheumatology (Oxford) 2021 01;60(1):34-47

Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, USA.

While prompt diagnosis of vasculitis is important, recognition of vasculitis mimics is equally essential. As in the case of vasculitis, an approach to mimics based on the anatomic size of vessels can be useful. Infections can mimic vasculitis of any vessel size, including the formation of aneurysms and induction of ANCAs. Read More

View Article and Full-Text PDF
January 2021