1,624 results match your criteria Cholesterol Embolism


Nontraumatic Multiple-Organ Fat Embolism: An Autopsy Case and Review of Literature.

Am J Forensic Med Pathol 2020 Jun;41(2):131-134

From the School of Forensic Medicine.

The patient was an 88-year-old woman with a 10-year history of hypertension. She was suspected to have been hit by a car. At the time of the event, she was conscious and able to stand on her own and had no obvious injuries. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000544DOI Listing

F-fluorodeoxyglucose-positron emission tomography/computed tomography for the diagnosis of polymyalgia-like illnesses: a retrospective study.

BMC Rheumatol 2020 24;4:21. Epub 2020 Apr 24.

1Division of Hematology and Rheumatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan.

Background: Various inflammatory conditions may present with musculoskeletal symptoms similar to those of polymyalgia rheumatica (PMR). We investigated findings on F-fluorodexoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) images that may differentiate PMR from polymyalgia-like illnesses.

Methods: We analyzed data from 25 patients with new-onset polymyalgia-like illnesses who fulfilled Bird's diagnostic criteria for PMR and had undergone FDG-PET/CT scan. Read More

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http://dx.doi.org/10.1186/s41927-020-00121-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181584PMC

Association between eosinophilia and renal prognosis in patients with pathologically proven cholesterol crystal embolism.

Clin Exp Nephrol 2020 Apr 7. Epub 2020 Apr 7.

Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa, 247-8533, Japan.

Background: Approximately, 20-70% of patients with cholesterol crystal embolism (CCE) have eosinophilia. However, it remains unknown how eosinophilia influences renal prognosis in patients with CCE. In this study, we investigated the association between eosinophil count (Eo) and renal prognosis in CCE patients on steroid therapy. Read More

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http://dx.doi.org/10.1007/s10157-020-01886-9DOI Listing

Clinical features and prognosis of acute myocardial infarction caused by non-tumor origin coronary artery embolism.

Am J Emerg Med 2020 Jun 24;38(6):1185-1191. Epub 2020 Mar 24.

Department of Cardiology, The Key Laboratory of Cardiovascular Disease of Wenzhou, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, PR China.

Background: Several studies have indicated that acute myocardial infarction (AMI) secondary to coronary artery embolism (CE) has a poor prognosis. However, in the latter studies, CE of tumor origin accounts for a considerable proportion of cases and the clinical features and contribution to overall prognosis of non-tumor CE are unknown and therefore the subject of this study.

Methods: We retrospectively studied 2006 consecutive patients with AMI at our medical center from January 2014 to October 2018. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.03.043DOI Listing
June 2020
1.152 Impact Factor

Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial.

Circulation 2020 May 29;141(20):1608-1617. Epub 2020 Mar 29.

Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA (D.L.B.).

Background: Patients with acute coronary syndrome are at risk for peripheral artery disease (PAD) events and venous thromboembolism (VTE). PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C) levels. Our objective was to ascertain whether PCSK9 inhibition reduces the risk of PAD events or VTE after acute coronary syndrome, and if such effects are related to levels of lipoprotein(a) or LDL-C. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242174PMC

The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism.

Circulation 2020 May 29;141(20):1600-1607. Epub 2020 Mar 29.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (N.A.M., Y.G., G.E.M.M., B.G., M.L.O., R.P.G., C.T.R., M.S.S.).

Background: The relationship between cholesterol levels and risk of venous thromboembolism (VTE) is uncertain. We set out to determine the effect of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition on the risk of VTE, explore potential mechanisms, and examine the efficacy in subgroups with clinically and genetically defined risk.

Methods: We performed a post hoc analysis of the FOURIER trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk) testing whether evolocumab reduces the risk of VTE events (deep venous thrombosis or pulmonary embolism). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046397DOI Listing

Iloprost in Acute Post-kidney Transplant Atheroembolism: A Case Report of Two Successful Treatments.

Front Med (Lausanne) 2020 28;7:41. Epub 2020 Feb 28.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, St. Orsola Hospital, University of Bologna, Bologna, Italy.

Cholesterol embolization (CE) is a rare and alarming post-transplant complication, responsible for primary non-function (PNF) or delayed graft function (DGF). Its incidence is expected to rise due to increasingly old donors and recipients and the extended criteria for donation. Therapy with statins and steroids has not been shown to be effective, while agonism of prostaglandin I has been reported to be useful in systemic CE. Read More

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http://dx.doi.org/10.3389/fmed.2020.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059607PMC
February 2020

[Cholesterol crystal embolism mimicking a DRESS].

Rev Med Interne 2020 Apr 20;41(4):275-278. Epub 2020 Feb 20.

Service de dermatologie, hôpital René Dubos-Pontoise, 6, avenue de l'île de France, 95300 Pontoise, France.

Introduction: Clinical presentation of cholesterol crystal embolism (CCE) can be dermatologic when cholesterol crystals become lodged in small cutaneous arteries resulting in ischemia. We report a case of CCE with erythroderma misleading to a diagnostic of drug reaction with eosinophilia and systemic symptoms (DRESS).

Case Report: A 66 year-old woman presented with erythroderma few months after initiation of allopurinol. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.01.007DOI Listing

Crystal Clots as Therapeutic Target in Cholesterol Crystal Embolism.

Circ Res 2020 Apr 24;126(8):e37-e52. Epub 2020 Feb 24.

From the Medizinische Klinik und Poliklinik IV, Klinikum der Universität, LMU München, Germany (C.S., T.K., S.S., S.R.M., L.Y., H.-J.A.).

Rationale: Cholesterol crystal embolism can be a life-threatening complication of advanced atherosclerosis. Pathophysiology and molecular targets for treatment are largely unknown.

Objective: We aimed to develop a new animal model of cholesterol crystal embolism to dissect the molecular mechanisms of cholesterol crystal (CC)-driven arterial occlusion, tissue infarction, and organ failure. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315625DOI Listing

[Update on cholesterol crystal embolism].

Rev Med Interne 2020 Apr 19;41(4):250-257. Epub 2020 Feb 19.

Service de médecine interne-vasculaire, centre hospitalier universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.

Cholesterol crystal embolism is a systemic pathology associated with diffuse atherosclerosis. Pathophysiology corresponds to tissue necro-inflammation secondary to arteriolar occlusion associated with microembolism from atherosclerotic plaques of large diameter arteries. The clinical presentation is heterogeneous and polymorphic. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.02.002DOI Listing

Successful treatment of cholesterol crystal embolism with anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody: a case report.

Ren Fail 2020 Nov;42(1):173-178

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

We report a unique case of renal cholesterol crystal embolism (CCE) induced by carotid artery stenting that was successfully treated with evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin kexin type 9 (PCSK9). A 77-year-old man with hypertension, hyperlipidemia, and chronic kidney disease was referred to our department for decreased estimated glomerular filtration rate (eGFR)-from 32.0 to 13. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1726383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034108PMC
November 2020

Stent-Assisted Angioplasty (SAA) at the Level of the Common Femoral Artery Bifurcation: Long-Term Outcomes.

Cardiovasc Intervent Radiol 2020 Apr 23;43(4):541-546. Epub 2020 Jan 23.

Department of Vascular Surgery, Ospedale Civico, Lugano, Switzerland.

Background: The objective of this retrospective single-center study was to report the initial and the long-term outcome after stent-assisted angioplasty of occlusive disease at the common femoral artery.

Materials And Methods: Between 1995 and 2015, 94 limbs in 79 consecutive patients (54 men; mean age 70 ± 8.6 years) underwent angioplasty with self-expanding stent implantation in 94 common femoral arteries. Read More

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http://dx.doi.org/10.1007/s00270-020-02413-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060158PMC

First case report of the coexistence of hydrophilic polymer embolism and cholesterol crystal embolism associated with an endovascular procedure.

J Dermatol 2020 Mar 7;47(3):e93-e95. Epub 2020 Jan 7.

Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan.

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http://dx.doi.org/10.1111/1346-8138.15223DOI Listing

Prevalence of Retinal Emboli and Acute Retinal Artery Occlusion in Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2020 Feb 16;29(2):104446. Epub 2019 Dec 16.

Oregon Stroke Center, Department of Neurology, Oregon Health and Science University, Portland, Oregon.

Objective: In population-based studies asymptomatic retinal emboli occur in .32%-2.9% of people. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104446DOI Listing
February 2020

[Kidney disease care for the elderly].

Nephrol Ther 2019 Dec 9;15(7):533-552. Epub 2019 Nov 9.

Service de néphrologie, hôpital Huriez, CHRU de Lille, 59037 Lille, France. Electronic address:

In our aging population, kidney disease management needs to take into account the frailty of the elderly. Standardized geriatric assessments can be proposed to help clinicians apprehend this dimension in their daily practice. These tools allow to better identify frail patients and offer them more personalized and harmless treatments. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.10.001DOI Listing
December 2019

Renal cholesterol crystal embolism in the setting of warfarin use.

BMJ Case Rep 2019 Aug 21;12(8). Epub 2019 Aug 21.

Nephrology, St. Mary's Hospital, Waterbury, Connecticut, USA.

A 73-year-old man presented for evaluation of weakness and black tarry stools that occurred 1 day prior to admission. His medical history is significant for diabetes mellitus, stage 3 chronic kidney disease and deep vein thrombosis on warfarin. He was admitted to the hospital and was found to have acute kidney injury and gastrointestinal bleeding due to a supratherapeutic International Normalized Ratio. Read More

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http://dx.doi.org/10.1136/bcr-2019-230314DOI Listing
August 2019
5 Reads

Cholesterol Crystal Embolization after Transcatheter Aortic-Valve Replacement.

N Engl J Med 2019 Aug;381(7):655

Hôpital Européen Georges-Pompidou, Paris, France

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http://dx.doi.org/10.1056/NEJMicm1815615DOI Listing
August 2019
1 Read

Carpal arch cholesterol embolism.

J Vasc Access 2020 Jan 7;21(1):126-127. Epub 2019 Aug 7.

Department of Vascular Surgery, Peupliers Private Hospital, Ramsay Générale de Santé, Paris, France.

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http://dx.doi.org/10.1177/1129729819867551DOI Listing
January 2020
2 Reads

Cholesterol-embolization syndrome: current perspectives.

Authors:
Abdullah Ozkok

Vasc Health Risk Manag 2019 8;15:209-220. Epub 2019 Jul 8.

Department of Internal Medicine and Nephrology, Memorial Şişli Hospital, Istanbul, Turkey.

Cholesterol-embolization syndrome (CES) is a multisystemic disease with various clinical manifestations. CES is caused by embolization of cholesterol crystals (CCs) from atherosclerotic plaques located in the major arteries, and is induced mostly iatrogenically by interventional and surgical procedures; however, it may also occur spontaneously. Embolized CCs lead to both ischemic and inflammatory damage to the target organ. Read More

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http://dx.doi.org/10.2147/VHRM.S175150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626893PMC
August 2019
2 Reads

[Prevention of "contrast-induced" acute kidney injury - practical considerations].

Dtsch Med Wochenschr 2019 08 26;144(15):1009-1013. Epub 2019 Jul 26.

Nephrologisches Zentrum, Medizinische Klinik IV, Klinikum der Universität München.

Acute kidney injury (AKI) episodes after iodine radiocontrast application are decreasing since non-ionic agents are routinely used. Retrospective studies (in total comprising more than 100 000 patients) DO NOT show increased AKI rates after CT scans with the application of radiocontrast (vs. uncontrasted CT scans). Read More

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http://dx.doi.org/10.1055/a-0840-7315DOI Listing
August 2019
2 Reads

The Solitary Blue Toe: A Unique Presentation of Antiphospholipid Syndrome.

J Am Podiatr Med Assoc 2019 May;109(3):235-240

Antiphospholipid syndrome is an autoimmune disease characterized by vascular thrombosis involving both the arterial and venous systems that can lead to tissue ischemia or end-organ damage. Much of the literature describes various symptoms at initial presentation, but isolated tissue ischemia manifesting as a solitary blue toe is unusual. We discuss a case of a 23-year-old man who presented to the emergency department with a solitary blue fourth digit with minimal erythema and edema, who was suffering from exquisite pain. Read More

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http://dx.doi.org/10.7547/17-108DOI Listing
May 2019
2 Reads

Aortogenic Embolic Stroke Diagnosed by a Pathological Examination of Endovascularly Removed Thrombus: An Autopsy Report.

Intern Med 2019 Oct 7;58(19):2851-2855. Epub 2019 Jun 7.

Department of Diagnostic Pathology, NTT Medical Center Tokyo, Japan.

Complex aortic atheroma is a high-risk factor for recurrent embolic stroke. An accurate identification of stroke etiology is clinically important; however, it can be challenging. A 91-year-old man with atrial fibrillation was diagnosed with cardioembolic stroke and treated with mechanical thrombectomy. Read More

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http://dx.doi.org/10.2169/internalmedicine.2857-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815896PMC
October 2019
2 Reads

Long-term outcome of biopsy-proven cholesterol crystal embolism.

Clin Exp Nephrol 2019 Oct 3;23(10):1181-1187. Epub 2019 Jun 3.

Nephrology Center, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.

Background: Cholesterol crystal embolism (CCE) causes renal damage, and there is an extremely high risk of end-stage renal disease. However, the time course of CCE-related renal deterioration varies and little is known about the subsequent risk of dialysis among patients with biopsy-proven CCE.

Methods: We performed a retrospective cohort study of 38 Japanese patients in whom a histological diagnosis of CCE was made from September 1992 to July 2005. Read More

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http://link.springer.com/10.1007/s10157-019-01749-y
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http://dx.doi.org/10.1007/s10157-019-01749-yDOI Listing
October 2019
16 Reads

Exploration of high-risk factors for pulmonary embolism in patients undergoing postoperative anti-thrombotic therapy among gynecologic oncology surgery: a retrospective study.

Ann Transl Med 2019 Apr;7(7):143

Department of Gynecology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China.

Background: The aim of this study was to find the high-risk factors of patients undergoing postoperative anti-thrombotic therapy that had a pulmonary embolism (PE).

Methods: In this retrospective analysis, a total of 35 patients with gynecologic oncological surgery were included from April 3, 2013, to January 12, 2018. Variable characteristic selection (Boruta's method), binary logistic regression (Fifth's method), and elastic network analysis were used to establish models and screen the high-risk factors. Read More

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http://dx.doi.org/10.21037/atm.2019.03.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511568PMC
April 2019
4 Reads

Visualization of a retinal embolus associated with branch retinal artery occlusion with OCT-angiography.

J Fr Ophtalmol 2019 06 13;42(6):668-670. Epub 2019 May 13.

Service d'ophtalmologie Pr Souied, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France; Centre d'imagerie et de laser, 11, rue Antoine-Bourdelle, 75015 Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S01815512193018
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http://dx.doi.org/10.1016/j.jfo.2018.12.018DOI Listing
June 2019
9 Reads

Cholesterol crystal embolism to the gastrointestinal tract: a catastrophic case.

Autops Case Rep 2019 Apr-Jun;9(2):e2018082. Epub 2019 Apr 5.

University of California, Davis Medical Center, Department of Pathology and Laboratory Medicine. Sacramento, CA, USA.

Cholesterol crystal embolism is a rare and easily overlooked cause of colonic ischemia. The gastrointestinal tract is the third most common organ system affected by cholesterol emboli, second only to kidney and skin. Here we present a catastrophic case of gastrointestinal cholesterol crystal embolism leading to extensive post-operative bowel infarction and ultimately death. Read More

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http://dx.doi.org/10.4322/acr.2018.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455701PMC
April 2019
3 Reads

The rash that leads to eschar formation.

Clin Dermatol 2019 Mar - Apr;37(2):99-108. Epub 2018 Dec 5.

Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA. Electronic address:

When confronted with an existent or evolving eschar, the history is often the most important factor used to put the lesion into proper context. Determining whether the patient has a past medical history of significance, such as renal failure or diabetes mellitus, exposure to dead or live wildlife, or underwent a recent surgical procedure, can help differentiate between many etiologies of eschars. Similarly, the patient's overall clinical condition and the presence or absence of fever can allow infectious processes to be differentiated from other causes. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.12.003DOI Listing
September 2019
7 Reads

Acute Renal Failure of Nosocomial Origin.

Dtsch Arztebl Int 2019 03;116(9):149-158

Background: 10-20% of hospitalized patients develop acute kidney injury (AKI)/acute renal failure during their hospital stay. The mortality of nosocomial AKI is approximately 30%.

Methods: This review is based on relevant publications retrieved by a search in multiple databases (PubMed and Uptodate), archives, and pertinent medical journals. Read More

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http://dx.doi.org/10.3238/arztebl.2019.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460009PMC
March 2019
6 Reads

The association of serum lipid level with ischemic stroke in the elderly of Xinjiang.

Neuro Endocrinol Lett 2019 Mar;39(8):572-578

Department of Neurology, Friendship Hospital to Urumqi, 830049, China.

Background: The aim of the present study is to determine the association of serum lipid level in the above 55-year-old age elderly with ischemic stroke (IS) in Xinjiang regions, China.

Methods: 408 patients with IS and 347 healthy individuals as control in the ≥55-year-old elderly were selected for the present study in Xinjiang province of China from July 2010 to July 2012. Patients were divided into different groups according to the IS subtypes (large-artery atherosclerosis, LAA; cardio-aortic embolism CE; small-artery occlusion, SAO), plague stability, hypertension and diabetes. Read More

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March 2019
8 Reads

[Acute kidney injury related to acute vascular disorders].

Rev Prat 2018 Feb;68(2):166-169

Service de néphrologie et transplantation, CHU Henri-Mondor, université Paris-Est Créteil, Créteil, France.

Acute kidney injury related to acute vascular disorders. A broad spectrum of vascular disease characterized by primary vessel involvement may be associated with acute renal failure. These diseases are usually classified according to the size of the injured vessel that include the small vessels (thrombotic microangiopathy, kidney injury due to malignant hypertension, scleroderma renal crisis, and cholesterol crystal embolism disease), the medium vessels (polyarteritis nodosa) or the large size vessels (acute renal infarction). Read More

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February 2018
9 Reads

A Catastrophic Case of Idiopathic Cholesterol Crystal Embolism with Multiple Lethal Complications: A Labyrinth Underneath the Diagnosis of Skin Ulcers in Chronic Kidney Disease Patients.

Intern Med 2019 Jun 1;58(12):1753-1758. Epub 2019 Feb 1.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Japan.

A 66-year-old man was admitted to our hospital because of multiple refractory skin ulcers. Based on his severe systemic arterial calcification and severe calcium-phosphate imbalance due to severe kidney dysfunction, we initially considered calciphylaxis. However, a skin biopsy provided a diagnosis of cholesterol crystal embolization. Read More

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http://dx.doi.org/10.2169/internalmedicine.2378-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630139PMC
June 2019
8 Reads

A rare case of spontaneous renal cholesterol crystallization embolism.

Chin Med J (Engl) 2019 02;132(3):367-369

Department of Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.

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http://dx.doi.org/10.1097/CM9.0000000000000078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595807PMC
February 2019
4 Reads

Cholesterol Crystals in Embolic Debris are Associated with Postoperative Cerebral Embolism after Carotid Artery Stenting.

Cerebrovasc Dis 2018 2;46(5-6):242-248. Epub 2019 Jan 2.

Department of Neurosurgery, Stroke Center, Ise Red Cross Hospital, Ise City, Japan.

Object: We investigated possible associations among the presence of cholesterol crystals in embolic debris, the proportions of debris components, and postoperative cerebral embolism in patients undergoing carotid artery stenting (CAS).

Methods: Sixty-seven consecutive procedures were performed for internal carotid artery stenosis with CAS at our hospital between November 2015 and February 2018. Procedures for emergency CAS for stroke in evolution or crescendo transient ischemic attack were excluded (n = 12). Read More

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http://dx.doi.org/10.1159/000495795DOI Listing
July 2019
11 Reads

Atrial cardiopathy in patients with embolic strokes of unknown source and other stroke etiologies.

Neurology 2019 01 5;92(4):e288-e294. Epub 2018 Dec 5.

From the Department of Medicine (Neurology) (S.J.), Queens' University, Kingston; Departments of Medicine (Neurology) (R.R., A.P.) and Medicine (Cardiology) (A.D.J., A.W.), Toronto Western Hospital/University Health Network, and Dalla Lana School of Public Health (R.N.), University of Toronto; and Centre for Urban Health Solutions (R.N.), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Objective: To investigate the prevalence and clinical determinants of atrial cardiopathy in patients with embolic stroke of unknown source (ESUS) and compare with other established stroke etiologies.

Methods: In a cross-sectional study of 846 consecutive patients with ischemic stroke, we compared the prevalence of atrial cardiopathy (defined by p-wave terminal force in V1 >5,000 µV·ms or severe left atrial enlargement) between ESUS patients and patients with large artery atherosclerosis (LAA) and small vessel disease (SVD) strokes. Baseline characteristics were also compared between ESUS and cardioembolic (CE) patients. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006748DOI Listing
January 2019
8 Reads

Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2018 11 27;11:CD012345. Epub 2018 Nov 27.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, UK, NR4 7TJ.

Background: Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is equivocal. Fish oils are rich in omega-3 PUFA and plant oils in omega-6 PUFA. Evidence suggests that increasing PUFA-rich foods, supplements or supplemented foods can reduce serum cholesterol, but may increase body weight, so overall cardiovascular effects are unclear. Read More

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http://dx.doi.org/10.1002/14651858.CD012345.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517012PMC
November 2018
17 Reads

[Benign Presentation of a Potentially Fatal Disease].

Rev Port Cir Cardiotorac Vasc 2018 Jan-Jun;25(1-2):77-82

Medicina Geral e Familiar, Unidade de Saúde Familiar São Martinho, Penafiel, Portugal.

Atheroembolism is a rare multisystemic disorder that is characterized by release of cholesterol crystals and particles from atheromatous plaques, which can occlude distal vessels and induce an inflammatory response. Most affected individuals are males, older than 60 years of age, with advanced atherosclerotic disease. The abdominal aorta is the most common origin of cholesterol emboli, being the peripheral arteries a rarer source. Read More

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July 2019
13 Reads

[Blue toe syndrome as a clinical finding of pheochromocytoma].

Medicina (B Aires) 2018 ;78(5):368-371

Servicio de Angiología y Cirugía Vascular, Hospital Universitario Central de Asturias (HUCA), Oviedo, España.

Pheochromocytomas are tumors that arise from chromaffin cells of the sympathetic nervous system and act by synthesizing and releasing catecholamines. They usually occur between the fourth and fifth decade of life and have a very wide clinical presentation. They occur only in 0. Read More

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September 2019
11 Reads

[Multimodal imaging approach to an embolus in a central retinal artery occlusion].

J Fr Ophtalmol 2018 Oct 14;41(8):e359-e360. Epub 2018 Sep 14.

Hôpital Nord, chemin des Bourrely, 13915 Marseille cedex, France.

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http://dx.doi.org/10.1016/j.jfo.2018.01.016DOI Listing
October 2018
1 Read

Cholesterol Crystal Embolization to the Kidney and to a Duodenal Leiomyoma.

ACG Case Rep J 2018 29;5:e62. Epub 2018 Aug 29.

Division of Gastroenterology Hepatology and Nutrition, NYU-Winthrop Hospital, Mineola, NY.

Cholesterol crystal embolism can be spontaneous or iatrogenic, and it can involve any organ of the gastrointestinal tract, presenting with common gastrointestinal symptoms such as bleeding, perforation, obstruction, and inflammation. It is therefore considered the "great masquerader," requiring a high level of suspicion because the condition is associated with increased morbidity and mortality. We present a 69-year-old man who presented with gastrointestinal bleeding and azotemia. Read More

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http://dx.doi.org/10.14309/crj.2018.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119206PMC
August 2018
10 Reads

Utilizing Whole-Exome Sequencing to Characterize the Phenotypic Variability of Sickle Cell Disease.

Genet Test Mol Biomarkers 2018 Sep 5;22(9):561-567. Epub 2018 Sep 5.

4 Department of Pediatrics, King Abdullah Specialist Children's Hospital , King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia .

Background: Sickle cell disease (SCD) is a monogenic disease that has wide variety of phenotypes with both and environmental factors contributing to its severity.

Methods: We performed whole-exome sequencing (WES) in 22 Saudi SCD patients to identify variants that could explain differences in disease phenotypes. All variants, except those that were benign and likely benign, described in the ClinVar database, were considered in our analysis. Read More

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https://www.liebertpub.com/doi/10.1089/gtmb.2018.0058
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http://dx.doi.org/10.1089/gtmb.2018.0058DOI Listing
September 2018
27 Reads

Purple finger syndrome: an exceptionally rare complication of infective endocarditis.

Pol Arch Intern Med 2018 09 27;128(9):552-553. Epub 2018 Jul 27.

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http://dx.doi.org/10.20452/pamw.4310DOI Listing
September 2018
4 Reads

Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2018 07 18;7:CD012345. Epub 2018 Jul 18.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, UK, NR4 7TJ.

Background: Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is equivocal. Fish oils are rich in omega-3 PUFA and plant oils in omega-6 PUFA. Evidence suggests that increasing PUFA-rich foods, supplements or supplemented foods can reduce serum cholesterol, but may increase body weight, so overall cardiovascular effects are unclear. Read More

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https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD
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https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD
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http://doi.wiley.com/10.1002/14651858.CD012345.pub2
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http://dx.doi.org/10.1002/14651858.CD012345.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513571PMC
July 2018
35 Reads

Complex disease management of pregnant young patient with familial hypercholesterolaemia complicated by coronary artery disease and cerebrovascular disease.

Cardiovasc Revasc Med 2018 12 5;19(8S):20-22. Epub 2018 Jul 5.

St George Hospital, 1 Grey St, Kogarah, New South Wales 2217, Australia.

Inherited disorders of lipid metabolism may cause a heavy burden of cardiovascular disease early in life. Familial hypercholesterolaemia (FH) with abnormalities of LDL metabolism results in marked LDL elevations and accelerated, multivessel atherosclerosis presenting in teenage or young adulthood. We describe the case of a 33-year-old woman who presented with exertional angina in the setting of pregnancy who was found post-partum to have severe triple-vessel disease including left main disease on coronary angiography (Figs. Read More

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http://dx.doi.org/10.1016/j.carrev.2018.06.024DOI Listing
December 2018
3 Reads

Visible-free cholesterol crystal emboli adjacent to microinfarcts in myocardial capillaries and arterioles on H&E-stained frozen sections of an autopsied patient.

BMJ Case Rep 2018 Jul 11;2018. Epub 2018 Jul 11.

Department of Cardiology, Cardiovascular Center, Osaka Gyoumeikan Hospital, Osaka, Japan.

The number of released free cholesterol crystal emboli (fCCE) and their role during percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) have not been documented yet. Furthermore, fCCE manifesting in the coronary lumen following plaque rupture has been historically overlooked owing to the standard tissue preparation for light microscopy which uses ethanol as a dehydrating agent that can dissolve fCCE, leaving behind empty tissue. In this case report, we evaluated fCCE released during PCI for ACS and their relationship with myocardial injury and coronary artery obstruction on the H&E-stained sections by using polarised light microscopy. Read More

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http://dx.doi.org/10.1136/bcr-2018-225558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047685PMC
July 2018
17 Reads

Novel Insights into Crystal-Induced Kidney Injury.

Kidney Dis (Basel) 2018 Jun 3;4(2):49-57. Epub 2018 Apr 3.

Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU Munich, Munich, Germany.

Background: The entity of crystal nephropathies encompasses a spectrum of different kidney injuries induced by crystal-formed intrinsic minerals, metabolites, and proteins or extrinsic dietary components and drug metabolites. Depending on the localization and dynamics of crystal deposition, the clinical presentation can be acute kidney injury, progressive chronic kidney disease, or renal colic.

Summary: The molecular mechanisms involving crystal-induced injury are diverse and remain poorly understood. Read More

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http://dx.doi.org/10.1159/000487671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029228PMC
June 2018
18 Reads

Plasma levels of high density lipoprotein cholesterol and outcomes in chronic thromboembolic pulmonary hypertension.

PLoS One 2018 29;13(5):e0197700. Epub 2018 May 29.

Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

Background: High Density Lipoprotein Cholesterol (HDL-C) has various anti-inflammatory, anti-atherogenic, anti-oxidant and anti-coagulant properties that improve vascular function. The utility of HDL-C as a biomarker of severity and predictor of survival was described in patients with pulmonary arterial hypertension (PAH). No prior study has assessed the utility of HDL-C in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197700PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973565PMC
December 2018
15 Reads

Midterm Outcomes of Endovascular Aortic Aneurysm Repair with Carbon Dioxide-Guided Angiography.

Ann Vasc Surg 2018 Aug 6;51:170-176. Epub 2018 Jun 6.

Department of Surgery and Clinical Science, Division of Vascular Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

Background: Although iodinated contrast (IC) agents are commonly used in endovascular aneurysm repair (EVAR), perioperative use in patients with renal dysfunction or IC allergies is avoided. Carbon dioxide (CO)-guided angiography is a promising alternative. We aimed to evaluate short-term and midterm outcomes of EVAR using CO-guided angiography. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.02.036DOI Listing
August 2018
39 Reads

Painful Erythematous-violaceous Toe: A Quiz.

Acta Derm Venereol 2018 Jul;98(7):719-720

Department of Dermatology, CHRU, Tours, France.

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http://dx.doi.org/10.2340/00015555-2953DOI Listing
July 2018
13 Reads
3.025 Impact Factor

Cholesterol embolisms as possible adverse drug reaction of direct oral anticoagulants.

Neth J Med 2018 04;76(3):125-128

Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the Netherlands.

The Netherlands Pharmacovigilance Centre Lareb has received two reports of cholesterol crystal embolisms associated with the use of a direct oral anticoagulant (DOAC). The European pharmacovigilance database contains several other cases concerning this association, and one report was published in the scientific literature. Cholesterol crystal embolisms were described in association with the use of several other antithrombotic drugs, although the role as an independent risk factor is not conclusive. Read More

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April 2018
5 Reads