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    1 OF 31

    Impact of Additional Lipid-Lowering Therapy on New Ischemic Lesions of Diffusion-Weighted Imaging in Carotid Artery Stenting.
    J Stroke Cerebrovasc Dis 2017 Nov 2. Epub 2017 Nov 2.
    Department of Neurosurgery, Hyogo Brain and Heart Center, Himeji City, Hyogo, Japan.
    Background: New ischemic lesions on diffusion-weighted imaging (DWI) are frequently found after carotid artery stenting (CAS) and sometimes cause neurologic deficit. We investigated the rate and the potential factor of new DWI lesions during the perioperative period of CAS in symptomatic patients at our institution.

    Materials And Methods: Of 187 consecutive patients who underwent CAS (April 2013-August 2016), we investigated 60 symptomatic patients with artery-to-artery embolism from carotid plaque. Read More

    Atrial fibrillation is associated with decreased total cerebral blood flow and brain perfusion.
    Europace 2017 Aug 9. Epub 2017 Aug 9.
    Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.
    Aims: Atrial fibrillation (AF) has been associated with cognitive impairment. Additionally, brain volume may be reduced in individuals with AF. Potential causes may include cerebral micro-embolism or reduced stroke volume due to the beat-to-beat variation in AF. Read More

    Cholesterol Crystal Embolism Induced by Direct Factor Xa inhibitor: A First Case Report.
    Intern Med 2017 Sep 25. Epub 2017 Sep 25.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.
    An 80-year-old man presented at our hospital with renal failure. He had been treated with edoxaban, an oral direct factor Xa inhibitor, for deep vein thrombosis for 10 months prior to admission. Although the pulses in his bilateral pedal arteries were palpable, cyanosis was present in the bilateral toes. Read More

    Acute Global Testicular Infarction Post-EVAR from Cholesterol Embolisation can be Mistaken for Torsion.
    EJVES Short Rep 2017 4;35:11-15. Epub 2017 Apr 4.
    Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia.
    Introduction: Endovascular aneurysm repair (EVAR) is the most commonly used approach for treatment of abdominal aortic aneurysms (AAA). Testicular infarction is a rare complication of EVAR. A novel case of acute global testicular infarction post-EVAR from cholesterol embolisation mimicking torsion is presented. Read More

    Statin use and venous thromboembolism in cancer: A large, active comparator, propensity score matched cohort study.
    Thromb Res 2017 Aug 10;158:49-58. Epub 2017 Aug 10.
    Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY, USA; Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, Gainesville, FL, USA. Electronic address:
    Background: Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE).

    Methods: Patients with newly diagnosed cancer were followed for up to one year in a healthcare claims database (2010-2013). Read More

    Multiple small intestinal ulcers associated with protein-losing enteropathy secondary to cholesterol crystal embolism:a case report.
    Nihon Shokakibyo Gakkai Zasshi 2017;114(8):1436-1445
    Department of Histopathology and Cytology, Kyoto Second Red Cross Hospital.
    A 78-year-old man with hypertension, nephrosclerosis, and angina pectoris visited his family doctor with a history of fatigue and leg edema. He had a history of percutaneous coronary intervention 5 years prior, and was taking low-dose aspirin. Blood tests revealed hypoalbuminemia, gastrointestinal (99m)Tc-HSA scintigraphy was positive, and alpha-1 antitrypsin clearance was high;therefore, the hypoalbuminemia was thought to be secondary to a protein-losing enteropathy. Read More

    Safety of low-molecular-weight heparin compared to unfractionated heparin in hemodialysis: a systematic review and meta-analysis.
    BMC Nephrol 2017 Jun 7;18(1):187. Epub 2017 Jun 7.
    Maisonneuve-Rosemont Hospital Research Center, Montreal, Canada.
    Background: Low molecular weight heparins (LMWH) have been extensively studied and became the treatment of choice for several indications including pulmonary embolism. While their efficacy in hemodialysis is considered similar to unfractionated heparin (UFH), their safety remains controversial mainly due to a risk of bioaccumulation in patients with renal impairment. The aim of this systematic review was to evaluate the safety of LMWH when compared to UFH for extracorporeal circuit (ECC) anticoagulation. Read More

    Cholesterol Crystal Embolism and Chronic Kidney Disease.
    Int J Mol Sci 2017 May 24;18(6). Epub 2017 May 24.
    Division of Nephrology, Tongji University School of Medicine, Shanghai 200120, China.
    Renal disease caused by cholesterol crystal embolism (CCE) occurs when cholesterol crystals become lodged in small renal arteries after small pieces of atheromatous plaques break off from the aorta or renal arteries and shower the downstream vascular bed. CCE is a multisystemic disease but kidneys are particularly vulnerable to atheroembolic disease, which can cause an acute, subacute, or chronic decline in renal function. This life-threatening disease may be underdiagnosed and overlooked as a cause of chronic kidney disease (CKD) among patients with advanced atherosclerosis. Read More

    Performing Anticoagulation: A Puzzling Case of Cholesterol Embolization Syndrome.
    Clin Med Insights Case Rep 2017 17;10:1179547616684649. Epub 2017 Feb 17.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke-Shi, Japan.
    The avoidance of any form of anticoagulation is advised in cases of cholesterol embolization syndrome (CES). We herein describe a case of CES in a man with a history of unprovoked pulmonary embolism for which warfarinization was performed. Despite anecdotal reports of successful anticoagulation in CES patients with certain indications, irreversible renal failure, which was sufficiently severe to require chronic hemodialysis, eventually developed in our patient. Read More

    Nontraditional Lipid Variables Predict Recurrent Brain Ischemia in Embolic Stroke of Undetermined Source.
    J Stroke Cerebrovasc Dis 2017 Aug 13;26(8):1670-1677. Epub 2017 Apr 13.
    Department of Neurology, University Hospital Donostia, San Sebastián, Spain; Faculty of Medicine, University of the Basque Country, Leioa, Spain.
    Objective: The aims of this study are, first, to calculate the risk of brain ischemia recurrence and embolic source diagnosis in the follow-up of patients with ESUS (embolic stroke of undetermined source) and, second, to identify the predictors of these events including cardiologic, laboratory, and clinical factors.

    Methods: A retrospective observational cohort study of stroke patients admitted to the stroke unit in a single tertiary hospital from 2012 to 2014 was performed. Patients fulfilling ESUS criteria were identified and followed by medical history review until March 2016. Read More

    Pharmacological secondary prevention in patients with mesenterial artery atherosclerosis and arterial embolism.
    Best Pract Res Clin Gastroenterol 2017 Feb 28;31(1):105-109. Epub 2016 Jul 28.
    Department of Vascular Diseases, Skåne University Hospital, 2-205 02 Malmö, Sweden. Electronic address:
    Visceral arteries such as the coeliac (CA), superior mesenteric (SMA), and the inferior mesenteric artery (IMA) might be affected by atherosclerotic occlusive lesions with or without thrombosis or embolization causing ischaemic symptoms from the gastrointestinal tract. After treatment of an acute event, these patients should be offered both non-pharmacological and pharmacological secondary prevention to reduce risk for future ischaemic arterial manifestations. Patients with mesenteric ischaemia caused by atherosclerosis should be evaluated concerning platelet antiaggregation with low dose aspirin or clopidogrel, and those with cardioembolic disease should be recommended anticoagulant treatment with either warfarin or one of the direct oral anticoagulants (DOAC; apixaban, dabigatran, edoxaban, or rivaroxaban). Read More

    Lipid levels and risk of recurrent venous thrombosis: results from the MEGA follow-up study.
    J Thromb Haemost 2017 Apr 25;15(4):695-701. Epub 2017 Feb 25.
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
    Essentials The role of lipid levels in the risk of recurrent venous thrombosis is unclear. Lipids were assessed in patients with a first venous thrombosis (n = 2106) followed for 6.9 years. Read More

    Axillo-femoral bypass steal due to subclavian artery stenosis.
    Heart Vessels 2016 Nov 5;31(11):1886-1888. Epub 2016 Mar 5.
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
    Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a novel finding of axillo-femoral bypass steal due to subclavian artery stenosis identified by vascular ultrasonography. Read More

    Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
    J Am Heart Assoc 2016 Oct 20;5(10). Epub 2016 Oct 20.
    Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, FL Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, FL Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD
    Background: The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We examined the association between the LS7 metrics and noncardiovascular disease.

    Methods And Results: We studied 6506 men and women aged between 45 and 84 years, enrolled in the Multi-Ethnic Study of Atherosclerosis. Read More

    The Characteristics of Retinal Emboli and its Association With Vascular Reperfusion in Retinal Artery Occlusion.
    Invest Ophthalmol Vis Sci 2016 Sep;57(11):4589-98
    Department of Ophthalmology Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
    Purpose: To analyze the characteristics of retinal emboli and their association with vascular reperfusion in retinal artery occlusion (RAO).

    Methods: In this retrospective comparative case series, we analyzed emboli in patients with acute central retinal artery occlusion (CRAO) or branch retinal artery occlusion (BRAO) and visible emboli, and analyzed vascular reperfusion in patients with visible emboli causing blockage of perfusion. The patients were divided into emboli "movement" and "no movement" groups and their vascular reperfusion states were compared. Read More

    Thrombophilia in Klinefelter Syndrome With Deep Venous Thrombosis, Pulmonary Embolism, and Mesenteric Artery Thrombosis on Testosterone Therapy: A Pilot Study.
    Clin Appl Thromb Hemost 2017 Nov 24;23(8):973-979. Epub 2016 Sep 24.
    2 The Cholesterol, Metabolism, and Thrombosis Center, Cincinnati, OH, USA.
    We compared thrombophilia and hypofibrinolysis in 6 men with Klinefelter syndrome (KS), without previously known familial thrombophilia, who had sustained deep venous thrombosis (DVT)-pulmonary emboli (PE) or mesenteric artery thrombosis on testosterone replacement therapy (TRT). After the diagnosis of KS, TRT had been started in the 6 men at ages 11, 12, 13, 13, 19, and 48 years. After starting TRT, DVT-PE or mesenteric artery thrombosis was developed in 6 months, 1, 11, 11, 12, and 49 years. Read More

    The Place of Nailfold Capillaroscopy Among Instrumental Methods for Assessment of Some Peripheral Ischaemic Syndromes in Rheumatology.
    Folia Med (Plovdiv) 2016 Apr-Jun;58(2):77-88
    Micro- and macrovascular pathology is a frequent finding in a number of common rheumatic diseases. Secondary Raynaud's phenomenon (RP) is among the most common symptoms in systemic sclerosis and several other systemic autoimmune diseases including a broad differential diagnosis. It should be also differential from other peripheral vascular syndromes such as embolism, thrombosis, etc. Read More

    Venous thromboembolism has the same risk factors as atherosclerosis: A PRISMA-compliant systemic review and meta-analysis.
    Medicine (Baltimore) 2016 Aug;95(32):e4495
    aEmergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vascular Disease, Beijing, China bDepartment of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
    Background: Previous studies have shown that idiopathic pulmonary embolism is positively associated with other cardiovascular events, such as myocardial infarction and stroke, suggesting a potentially important association between atherosclerosis risk factors and venous thromboembolism (VTE). We performed a meta-analysis to evaluate the correlation between risk factors for atherosclerosis and VTE.

    Methods: In December 2014, we searched MEDLINE and EMBASE for studies evaluating the associations between VTE and risk factors for atherosclerosis and pooled outcome data using random-effects meta-analysis. Read More

    Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review.
    Exp Ther Med 2016 Aug 17;12(2):1012-1018. Epub 2016 May 17.
    Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.
    Cholesterol embolism is a multisystemic disorder with clinical manifestations that resemble vasculitis. Anti-neutrophil cytoplasmic antibodies (ANCA) are a defining feature of ANCA-associated vasculitis, and the presence of ANCA in cholesterol embolism complicates its differential diagnosis and treatment. At present, the role of ANCA in cholesterol embolism remains unclear and no effective treatment is currently available. Read More

    Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome.
    Respir Res 2016 Jul 19;17(1):86. Epub 2016 Jul 19.
    Department of Emergency Medicine and Department of Cellular and Integrative Physiology, Indiana University Medical School, 720 Eskanazi Avenue, Indianapolis, IN, 46202, USA.
    Background: Pulmonary thromboembolism (PTE) is a common diagnosis and a leading cause of cardiovascular morbidity and mortality. A growing literature has associated PE with systemic inflammation, and global hyper-coagulability, which contribute to lung remodeling and clot recurrence. The source and mechanism of inflammation remains unstudied. Read More

    Uptake of evidence-based statin therapy among atrial fibrillation patients in China: A report from the CAFR (Chinese Atrial Fibrillation Registry) Study.
    Int J Cardiol 2016 Oct 23;220:284-9. Epub 2016 Jun 23.
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing, China. Electronic address:
    Background: Atrial fibrillation (AF) is associated with increased incidence of cardiovascular disease, and hence, statin therapy is indicated in majority of AF patients.

    Methods And Results: We analyzed data from the Chinese Atrial Fibrillation Registry (CAFR) involving 11,496 AF patients from 2011 to 2014. Practice patterns of statin therapy and factors associated with statin underuse were analyzed. Read More

    Value of D-dimer and HDL cholesterol concentrations in predicting the occurrence of acute pulmonary embolism.
    Pol Merkur Lekarski 2016 May;40(239):283-7
    Medical University of Lodz, Poland: Department of Pharmacology and Toxicology.
    Unlabelled: Pulmonary embolism (PE) usually is a clinical manifestation of venous thromboembolism. The lack of simple and safe laboratory test to confirm or exclude PE is a problem that slows down the diagnosis.

    Aim: The aim of the study was the assessment the usefulness of D-dimer and HDL cholesterol concentration in predicting the occurrence of acute pulmonary embolism. Read More

    [Anti-Thrombotic Properties of High-Density Lipoprotein].
    Rinsho Byori 2016 Jan;64(1):66-71
    Along with the established evidence on the association between a low HDL cholesterol level and arterial thrombosis, several limited studies have suggested that low HDL cholesterol is also a risk factor for venous thrombosis, such as deep vein thrombosis and pulmonary embolism. As well as emerging evidence from clinical studies, basic research has proposed the interaction between HDL and key molecules in the field of thrombosis and hemostasis; HDL interacts with megakaryocytes to affect the production of platelets, suppresses the aggregation of platelets, protects against the injury of endothelial cells, and inhibits coagulation and fibrinolysis cascades. Considering these reports together, HDL can possess anti-thrombotic properties as one of its pleiotropic effects other than its role in the reverse transport system of cholesterol. Read More

    A case of repeated small bowel perforations in a short period in a patient with cholesterol crystal embolism.
    Nihon Shokakibyo Gakkai Zasshi 2016 05;113(5):804-12
    Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School.
    We report a case of jejunal perforation related to cholesterol crystal embolism (CCE) in a woman in her seventies. The jejunum was partially resected;histological examination of the resected tissue revealed that the perforation was caused by CCE. On postoperative day 12, computed tomography (CT) showed free air in the abdomen. Read More

    Cholesterol embolization syndrome: A report of two cases.
    Turk Kardiyol Dern Ars 2016 Apr;44(3):251-5
    Department of Internal Medicine and Nephrology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
    Cholesterol embolization syndrome (CES) is a multisystemic disease with immunological features, and a rare but an important cause of acute kidney injury (AKI) following invasive angiography. It frequently occurs in the elderly male population with extensive atherosclerosis. CES should be considered in the differential diagnosis of AKI following angiography, as prognosis and treatment are completely different from contrast-induced nephropathy. Read More

    Efficacy of low-density lipoprotein apheresis combined with corticosteroids for cholesterol crystal embolism.
    Clin Exp Nephrol 2017 Apr 21;21(2):228-235. Epub 2016 Apr 21.
    Department of Nephrology, Japan Community Health Care Organization Sendai Hospital, 3-16-1 Tsutsumimachi, Aoba-ku, Sendai, Miyagi, 981-8501, Japan.
    Background: Corticosteroids have been widely used in patients with cholesterol crystal embolism (CCE) and low-density lipoprotein apheresis (LDL-A) was reported to reduce the risk of end-stage renal disease in patients with CCE. This study was designed to evaluate the renoprotective effects of LDL-A in combination with corticosteroids in patients with CCE.

    Methods: Thirty-five patients with CCE who, between 2008 and 2013, had shown renal deterioration after vascular interventions were retrospectively evaluated. Read More

    Atheroembolization and potential air embolization during aortic declamping in open repair of a pararenal aortic aneurysm: A case report.
    Int J Surg Case Rep 2016 13;23:89-92. Epub 2016 Apr 13.
    Department of Pathology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; The Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway. Electronic address:
    Introduction: When ischemic events ascribable to microembolization occur during open repair of proximal abdominal aortic aneurysms, a likely origin of atheroembolism is not always found.

    Presentation Of Case: A 78-year old man with enlargement of the entire aorta underwent open repair for a pararenal abdominal aortic aneurysm using supraceliac aortic clamping for 20min. Then the graft was clamped, the supraceliac clamp was removed, and the distal and right renal anastomoses were also completed. Read More

    Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study.
    J Thromb Haemost 2016 Jun 10;14(6):1183-91. Epub 2016 May 10.
    K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.
    Unlabelled: Essentials Registry-based studies indicate a link between arterial- and venous thromboembolism (VTE). We studied this association in a cohort with confounder information and validated outcomes. Myocardial infarction (MI) was associated with a 4. Read More

    Ileus caused by cholesterol crystal embolization: A case report.
    World J Gastroenterol 2016 Mar;22(12):3502-5
    Shunjiro Azuma, Maiko Ikenouchi, Takuji Akamatsu, Takeshi Seta, Shunji Urai, Yoshito Uenoyama, Yukitaka Yamashita, Department of Gastroenterology, Japan Red Cross Society Wakayama Medical Center, Wakayama-city, Wakayama 640-8558, Japan.
    Cholesterol crystal embolization (CCE) is a rare systemic embolism caused by formation of cholesterol crystals from atherosclerotic plaques. CCE usually occurs during vascular manipulation, such as vascular surgery or endovascular catheter manipulation, or due to anticoagulation or thrombolytic therapy. We report a rare case of intestinal obstruction caused by spontaneous CCE. Read More

    The Association of Coronary Artery Calcium With Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
    JACC Cardiovasc Imaging 2016 May 9;9(5):568-576. Epub 2016 Mar 9.
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA.
    Objectives: This study sought to determine if coronary artery calcium (CAC) is associated with incident noncardiovascular disease.

    Background: CAC is considered a measure of vascular aging, associated with increased risk of cardiovascular and all-cause mortality. The relationship with noncardiovascular disease is not well defined. Read More

    Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia.
    BMC Hematol 2016 8;16. Epub 2016 Mar 8.
    Internal Medicine Residency Program, Cholesterol, Metabolism, and Thrombosis Center of the Jewish Hospital of Cincinnati, 2135 Dana Avenue, Suite 430, Cincinnati, OH 45207 USA.
    Background: In patients hospitalized over a 4 year period for pulmonary embolism (PE), we assessed relationships of testosterone (TT) and estrogen therapy (ET) anteceding PE in patients found to have familial-acquired thrombophilia.

    Methods: From 2011 through 2014, 347 patients were hospitalized in Cincinnati Mercy Hospitals with PE. Retrospective chart review was used to identify patients receiving TT or ET before PE; coagulation studies were done prospectively if necessary. Read More

    Multisystem diseases affecting the skin and eye.
    Clin Dermatol 2016 Mar-Apr;34(2):214-41. Epub 2015 Nov 22.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:
    There exist a wide variety of multisystem diseases that can affect both the eyes and skin. The skin and eyes may be the initial sites affected, leading to a new diagnosis of a systemic illness, or severe skin and eye involvement can drive treatment for patients with multisystem disease. It is important for physicians to be aware of how to recognize and diagnose these conditions, to evaluate patients for extent of disease, and to initiate appropriate therapies to combat these potentially severe diseases. Read More

    [A Case That in Most Part of the Metastatic Liver Tumor Fell into Spontaneous Necrosis after Surgery of Rectal Cancer].
    Gan To Kagaku Ryoho 2015 Nov;42(12):2285-7
    Dept. of Surgery, Saiseikai Yahata General Hospital.
    We present a case of a 74-year-old woman treated with maintenance dialysis for chronic renal failure. She had undergone intravascular treatment of lower limb arteriosclerosis obliterans 3 times. Low anterior resection was performed for rectal cancer StageⅡ, but adjuvant chemotherapy was not administered after the operation. Read More

    Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry.
    Korean J Intern Med 2016 Mar 27;31(2):305-12. Epub 2016 Jan 27.
    Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital and Lung Research Institute, Hallym University College of Medicine, Seoul, Korea.
    Background/aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. Read More

    [Drug-induced acute kidney injury].
    Ther Umsch 2015 Dec;72(11-12):717-27
    1 Universitätsklinik für Nephrologie, Hypertonie und Klinische Pharmakologie, Inselspital Bern.
    Due to their physiological function, the kidneys are exposed to high concentrations of numerous drugs and their metabolites, making them vulnerable to drug-related injuries. This article provides an overview of the pathophysiological mechanisms involved in nephrotoxicity, the most common nephrotoxic drugs, and the risk factors for the occurrence of drug-induced acute kidney injuries. NSAIDs, diuretics, ACE inhibitors, and angiotensin II receptor blockers (ARBs} are the most frequent prerenal causes of an acute elevation in creatinine levels. Read More

    Thrombophilia in 67 Patients With Thrombotic Events After Starting Testosterone Therapy.
    Clin Appl Thromb Hemost 2016 Sep 30;22(6):548-53. Epub 2015 Nov 30.
    Cholesterol, Metabolism, and Thrombosis Center, Jewish Hospital of Cincinnati, Cincinnati, OH, USA.
    We compared thrombophilia in 67 cases (59 men and 8 women) with thrombotic events after starting testosterone therapy (TT) versus 111 patient controls having unprovoked venous thrombotic events without TT. In the 67 patients, thrombosis (47 deep venous thrombosis-pulmonary embolism, 16 osteonecrosis, and 4 ocular thrombosis) occurred 6 months (median) after starting TT. Cases differed from controls for factor V Leiden heterozygosity (16 of the 67 [24%] vs 13 [12%] of the 111, P = . Read More

    Association of Serum Cholesterol Levels with Short-term Mortality in Patients with Acute Pulmonary Embolism.
    Heart Lung Circ 2016 Apr 9;25(4):365-70. Epub 2015 Oct 9.
    Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.
    Background: Serum cholesterols play an important role in pathophysiology and prognosis of acute thrombotic diseases. The aim of the present study was to investigate the prognostic value of serum lipid parameters in acute pulmonary embolism (APE).

    Methods: From January 2008 to January 2014 a total of 275 patients who were hospitalised with a diagnosis of APE were retrospectively screened. Read More

    Hydrodynamic evaluation of a new dispersive aortic cannula (Stealthflow).
    J Artif Organs 2016 Jun 2;19(2):121-7. Epub 2015 Nov 2.
    Department of Cardiovascular Surgery, Aomori Municipal Hospital, Aomori, Japan.
    The aim of this study was to evaluate flow from a new dispersive aortic cannula (Stealthflow) in the aortic arch using flow visualization methods. Particle image velocimetry was used to analyze flow dynamics in the mock aortic model. Flow patterns, velocity distribution, and streamlines with different shape cannulas were evaluated in a glass aortic arch model. Read More

    Late Onset of Cholesterol Embolism Leading to Graft Failure After Renal Transplantation: Report of Two Cases.
    Transplant Proc 2015 Oct;47(8):2361-3
    Nephrology Department of the University Hospital "GermansTrias I Pujol", Badalona, Spain; REDinREN 12/0021/0027, Fundación Jiménez Díaz Hospital, Madrid, Spain. Electronic address:
    Cholesterol-crystal embolization (CE) usually presents as an acute or subacute multisystemic disease. When affecting native kidneys prognosis is poor, often leading to chronic kidney disease. Presentation in renal allografts is a rare condition although probably underdiagnosed. Read More

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