39,189 results match your criteria Cholelithiasis

Gemfibrozil-Induced Polyuria.

Eur J Case Rep Intern Med 2021 27;8(4):002546. Epub 2021 Apr 27.

Patient First Medical Center affiliated with Beaumont Hospital, Dearborn, Michigan USA.

Gemfibrozil is a lipid-regulating agent used mainly to treat patients with hypertriglyceridaemia, especially those at risk for acute pancreatitis. Like any other pharmacological agent, gemfibrozil has known adverse effects, mainly gastrointestinal, such as cholelithiasis, gallstones, elevated transaminase, and other non-specific symptoms including dyspepsia, nausea and vomiting. Other reported adverse reactions are dizziness and vertigo, myopathy and rhabdomyolysis, angioedema, urticaria and rash. Read More

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Clear-Cell Adenocarcinoma of the Gallbladder with Alpha-Fetoprotein Production: A Case Report and Review of the Literature.

Gastrointest Tumors 2021 Apr 27;8(2):52-57. Epub 2021 Jan 27.

Department of Urology, Indraprashtha Apollo Hospital, Delhi, India.

Gallbladder tumors are the fifth most common cancers of the gastrointestinal tract with poor prognosis and low survival. The most common type is adenocarcinoma of which the clear cell type is an unusual histologic variant with alpha-fetoprotein (AFP)-producing gallbladder carcinoma, reported extremely rarely, which makes the index case an uncommon entity. AFP secretion by gallbladder carcinomas may occur given the similar embryological origin of liver and gallbladder. Read More

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Upper Gastrointestinal Bleeding: A Potential Precursor to Bouveret's Syndrome.

Cureus 2021 Apr 8;13(4):e14368. Epub 2021 Apr 8.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.

Bouveret's syndrome is a rare complication of cholelithiasis. It is characterized by a gallstone entering the intestine through a cholecystoenteric fistula, impacting the duodenum and causing gastric outlet obstruction. Rarely, it presents with hematemesis and melena. Read More

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Acute Pancreatitis in Children: The Clinical Profile at a Tertiary Hospital.

Cureus 2021 May 6;13(5):e14871. Epub 2021 May 6.

Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, BHR.

Objectives The clinical course and progression of acute pancreatitis are poorly understood to date, necessitating more studies of clinical profiles during the disease. Moreover, understanding the etiologies and clinical presentations of acute pancreatitis (AP) in children can contribute to early diagnosis and, hence, earlier interventions. Therefore, this article aims to study the clinical profiles of children with acute pancreatitis (AP) in relation to complications and other variables. Read More

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Horseshoe kidney leading to ERCP failure; innovative use of guide wire during laparoscopic CBD exploration: A case report.

Int J Surg Case Rep 2021 Apr 29;82:105927. Epub 2021 Apr 29.

Department of General Surgery, Mata Chanan Devi Hospital, New Delhi, India.

Introduction: Horseshoe kidneys are the most common fusion defect of the kidneys, which amounts to about 0.25% of the population. They are usually asymptomatic and are often identified incidentally. Read More

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A rare case of gallstone ileus-the unanswered question.

Chi Fai Tsang

J Surg Case Rep 2021 Apr 29;2021(4):rjab164. Epub 2021 Apr 29.

Department of General Surgery, Prince of Wales Hospital and Community Health Services, Sydney, New South Wales 2002, Australia.

Gallstone ileus is caused by an impaction of one or more gallstones within the gastrointestinal tract leading to mechanical intestinal obstruction. It is a rare complication of cholelithiasis and found in 2-3% of all cases associated with recurrent episodes of cholecystitis. This case study demonstrates an atypical presentation of gallstone ileus. Read More

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Elderly patients (≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients (< 80 years): Propensity score-matched analysis.

World J Hepatol 2021 Apr;13(4):456-471

Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore.

Background: Acute cholangitis (AC) is a disease spectrum with varying extent of severity. Age ≥ 75 years forms part of the criteria for moderate (Grade II) severity in both the Tokyo Guidelines (TG13 and TG18). Aging is associated with reduced physiological reserves, frailty, and sarcopenia. Read More

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Is Previous Upper Abdominal Surgery a Contraindication for Laparoscopic Cholecystectomy?

Cureus 2021 Apr 3;13(4):e14272. Epub 2021 Apr 3.

General Surgery, Yozgat Bozok University Faculty of Medicine, Yozgat, TUR.

Background and objective In this era of minimally invasive surgery and enhanced recovery procedures, laparoscopic cholecystectomy (LC) is the prevailing treatment method for symptomatic cholelithiasis. However, there are some contraindications for this operation, such as a previous upper abdominal surgery. Additionally, the median conversion rate of LC is 5%. Read More

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Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined.

N Engl J Med 2021 05;384(18):1719-1730

From the Department of Biomedical Sciences (J.R.L., C.J., S.B.K.J., C.R.J., L.M.O., R.M.C., M.B.B., B.M.S., J.J.H., S.S.T.), the Novo Nordisk Foundation Center for Basic Metabolic Research (J.R.L., C.J., S.B.K.J., C.R.J., L.M.O., R.M.C., J.J.H., S.S.T.), the Department of Clinical Medicine (T.B., J.-E.B.J.), University of Copenhagen, and the Departments of Endocrinology (M.S.S., K.N.B.-M., J.-E.B.J., S.M.) and Clinical Research (T.B.), Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, and the Steno Diabetes Center Copenhagen, Gentofte (M.B.B.) - all in Denmark.

Background: Weight regain after weight loss is a major problem in the treatment of persons with obesity.

Methods: In a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of the height in meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year to one of four strategies: a moderate-to-vigorous-intensity exercise program plus placebo (exercise group); treatment with liraglutide (3. Read More

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Estrogen-induced gallstone pancreatitis in a transgender female.

Am J Health Syst Pharm 2021 May 5. Epub 2021 May 5.

University of Missouri Hospitals, Columbia, MO, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Efficacy of evaluation of microRNA-122 and microRNA-21 levels in the role of biomarkers of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis.

Pol Merkur Lekarski 2021 Apr;49(290):108-113

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Aim: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis.

Materials And Methods: The study included 32 patients who were divided into two groups: I - study group and II - comparison group. The study group included patients with acute calculous cholecystitis (ACC) and oligosymptomatic choledocholithiasis (OCL) (n=23), and the comparison group consisted of patients with ACC without choledocholithiasis (n=9). Read More

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Leptin Influence Cholelithiasis Formation by Regulating Bile Acid Metabolism.

Turk J Gastroenterol 2021 Jan;32(1):97-105

Department of Hepatobiliary Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, China.

Background: Bile acid metabolism is a contributing factor that promotes cholelithiasis. Recent studies have suggested novel roles of leptin in the formation of gallbladder stones (GS); however, no evidence confirmed the function of leptin in the formation of primary intrahepatic bile duct stones (PIBDS) . In the current study, the liver tissues of patients with GS and PIBDS were collected to check the mRNA and protein expression levels of BSEP. Read More

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January 2021

Bouveret syndrome: a rare cause of gastric outlet obstruction.

BMJ Case Rep 2021 Apr 22;14(4). Epub 2021 Apr 22.

Department of General Surgery, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

Bouveret syndrome is a rare cause of gastric outlet obstruction. It is characterised by the presence of an obstructing gallstone in the pylorus or proximal duodenum, which has travelled to its obstructing position via an acquired fistula. Our case involves a 73-year-old man presenting to the acute surgical take with a 2-day history of right-sided abdominal pain and vomiting. Read More

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Reply to Phillpotts and Webster.

Endoscopy 2021 05 22;53(5):560. Epub 2021 Apr 22.

Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

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The role of endoscopic papillary large balloon dilatation without sphincterotomy.

Endoscopy 2021 05 22;53(5):559. Epub 2021 Apr 22.

Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK.

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Author commentary on Li Huang et al.


Endoscopy 2021 05 22;53(5):v21. Epub 2021 Apr 22.

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Role of osteopontin in diet-induced brown gallstone formation in rats.

Chin Med J (Engl) 2021 Apr 20;134(9):1093-1100. Epub 2021 Apr 20.

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Background: Although osteopontin (OPN) is expressed in the liver and pigment gallstones of patients with hepatolithiasis, its role in pigment gallstone formation remains unclear. This study aimed to explore the function of OPN in pigment gallstone formation.

Methods: Rats were fed a chow diet (CD) or lithogenic diet (LD) for 10 consecutive weeks; blocking tests were then performed using an OPN antibody (OPN-Ab). Read More

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Cholelithiasis and cholecystitis in children and adolescents: Does this increasing diagnosis require a common guideline for pediatricians and pediatric surgeons?

BMC Gastroenterol 2021 Apr 21;21(1):186. Epub 2021 Apr 21.

Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Pediatric Surgery, Department of Surgery, University Hospital Erlangen, Erlangen, Germany.

Background: In contrast to adults, for whom guidelines on the cholelithiasis treatment exist, there is no consistent treatment of pediatric patients with cholelithiasis throughout national and international departments, most probably due to the lack of evidence-based studies.

Methods: We evaluated the German management of pediatric cholelithiasis in a dual approach. Firstly, a retrospective, inter-divisional study was established, comparing diagnostics and therapy of patients of the pediatric surgery department with the management of patients aged < 25 years of the visceral surgery department in our institution over the past ten years. Read More

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Direct cholangioscopy using a standard-size gastroscope to guide mechanical lithotripsy after failed ERCP-based basket capture.

Vincent Zimmer

Gastroenterol Hepatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Medicine, Marienhausklinik St. Josef Kohlhof, Neunkirchen, Germany; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany. Electronic address:

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A Rare Case of Cholecystoduodenal Fistula with Rapid Distal Gallstone Migration.

Am J Case Rep 2021 Apr 19;22:e929150. Epub 2021 Apr 19.

Department of General Surgery, Ascension Michigan Genesys Hospital, Grand Blanc, MI, USA.

BACKGROUND Abnormal communicating channels or fistulas between the gallbladder or common bile duct and the intestine are rare, but have potential to result in serious complications. Further complications can arise with migration of gallstones from the gallbladder to the intestines, causing distal obstruction in the ileum, intestinal hemorrhage, or intestinal perforation. High clinical suspicion is warranted for the diagnosis of Bouveret's syndrome, with anticipation of surgery to prevent distal gallstone migration that would otherwise result in unfavorable patient outcomes. Read More

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The Use of Bedside Ultrasound for Gallstone Disease Care within a Community-based Emergency Department: A Confirmation Bias.

Spartan Med Res J 2021 Apr 13;6(1):18182. Epub 2021 Apr 13.

Ascension Macomb.

Introduction: Traditional evaluation for suspicion of gallstone or gallbladder-related disease includes evaluation with a formal technician-performed ultrasound. However, the use of point-of-care bedside ultrasounds (Bedside US) has been shown to be a viable alternative for the diagnosis of gallstones and gallbladder-related diseases. : The purpose of this study was to evaluate the impact of Bedside US use in gallbladder evaluation on key patient care outcomes within our community-based emergency department setting. Read More

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Risk of Asymptomatic Gallstones Becoming Symptomatic After Laparoscopic Sleeve Gastrectomy.

Am Surg 2021 Apr 18:31348211011107. Epub 2021 Apr 18.

Türkçapar Bariatrics, Obesity Center, Turkey.

Background: Whether concomitant cholecystectomy is needed during laparoscopic sleeve gastrectomy (LSG) in patients with asymptomatic cholelithiasis is controversial. In this study, our aim is to show the follow-up results in patients with asymptomatic cholelithiasis who underwent LSG alone.

Methods: Patients undergoing primary LSG between March 2018 and September 2020 with asymptomatic gallbladder stones were included in this retrospective study. Read More

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Remaining cist syndrome in a cholecystectomidez patient confirmed by conlangiography.

Rev Esp Enferm Dig 2021 Apr 19. Epub 2021 Apr 19.

Medicina Interna, Especialidades Médicas y Cuidado, Hospital Comarcal de Baza.

A 59-year-old man with cholelithiasis and choledocholithiasis and biliary obstruction due to enolic chronic pancreatitis treated via cholecystectomy, ERCP, and a fully coated biliary metal stent for 6 months, 7 years ago. He attended the emergency department due to progressive jaundice and abdominal pain. An abdominal ultrasound showed a "non-distended gallbladder with a 12 mm lithiasis and biliary mud with dilatation of the intrahepatic (IBD) and extrahepatic (EBD) bile duct". Read More

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Unusual cause of gas complicating a biloma, postcholecystectomy.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Radiology Department, University Hospitals Dorset NHS Foundation Trust, Poole, UK.

A 50-year-old man presented to the emergency department with abdominal pain, vomiting and fever. He had been admitted 6 months ago with acute cholecystitis when he underwent endoscopic retrograde cholangiopancreatography (ERCP) to remove ductal gallstones. Elective cholecystectomy was performed 3 days prior to the current admission. Read More

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Surgical Management of Feline Extrahepatic Biliary Tract Diseases.

Top Companion Anim Med 2021 Apr 20;44:100534. Epub 2021 Apr 20.

Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address:

Extrahepatic biliary obstruction occurs infrequently in cats. Pathophysiology of biliary obstruction is characterized by cholestasis, obstruction, inflammation, and exudation. Clinical signs and laboratory examination findings are nonspecific. Read More

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Effects of the timing of laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreatography on liver, bile, and inflammatory indices and cholecysto-choledocholithiasis patient prognoses.

Clinics (Sao Paulo) 2021 9;76:e2189. Epub 2021 Apr 9.

Department of Immunization Program, Center for Disease Control and Prevention of Hailing District, Taizhou City, Jiangsu Province, China.

Objectives: This study explored the effects of the timing of laparoscopic cholecystectomy (LC) after endoscopic retrograde cholangiopancreatography (ERCP) on liver function, bile biochemical indices, inflammatory reactions, and cholecysto-choledocholithiasis patient prognoses.

Methods: A total of 103 cholecysto-choledocholithiasis patients were stratified into control (CG; n=51; LC at 4-7 d after ERCP) and observation groups (OG; n=52; LC at 1-3 d after ERCP) using a random number table.

Results: The surgical time was shorter and intraoperative blood loss was less in OG than in CG, and the two groups were not statistically different in terms of time to the first passage of gas through anus, length of postoperative hospital stay, conversion rate to laparotomy, and stone-free rate. Read More

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[Prevalence of cholelithiasis and gallbladder cancer among Aymara individuals].

Rev Med Chil 2020 Oct;148(10):1398-1405

Hospital Dr. Ernesto Torres Galdames, Iquique, Chile.

Background: The prevalence of cholelithiasis and gallbladder cancer may be different across ethnic groups.

Aim: To study the prevalence of cholelithiasis and gallbladder cancer among Aymara individuals.

Material And Methods: An abdominal ultrasound was carried out in a sample of 182 Aymara women aged 46 ± 16 years and 76 Aymara men aged 55 ± 16 years. Read More

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October 2020

A novel compound heterozygous mutation in ABCB4 gene in a pedigree with progressive familial intrahepatic cholestasis 3: a case report.

Ann Transl Med 2021 Mar;9(5):426

Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You An Hospital, Capital Medical University, Beijing, China.

Progressive familial intrahepatic cholestasis (PFIC) includes a group of genetic autosomal recessive disorders that predominantly affects young children and results in early-onset progressive liver damage. Variations in have been shown to cause PFIC3. However, the association between genotype and clinical manifestations remains unclear. Read More

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Staples Versus Sutures for Skin Closure in Standard Four Port Laparoscopic Cholecystectomy: A Prospective Cohort Study.

Cureus 2021 Mar 6;13(3):e13725. Epub 2021 Mar 6.

General Surgery, All India Institute of Medical Sciences, Rishikesh, IND.

Introduction Many studies have been done comparing sutures versus skin staples in various wounds. To the author's knowledge, there is no study comparing these two in an laparoscopic cholecystectomy (LC) wound. Our study aims at comparing the clinical outcome of skin closure by monofilament nylon suture and stainless-steel skin stapler in standard four-port LC. Read More

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