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Isr Med Assoc J 2022 May;24(5):306-309

Department of Surgery, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel.

Background: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on healthcare systems worldwide. The fear of seeking medical attention to avoid the possibility of being infected may have altered the course of some diseases.

Objectives: To describe our experience with the management of patients with acute cholecystitis during the pandemic at our medical center. Read More

HPB (Oxford) 2022 May 6. Epub 2022 May 6.

The Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen, UK; Department of General Surgery, Aberdeen Royal Infirmary, NHS Grampian, UK.

Background: Compare outcomes of early laparoscopic cholecystectomy (ELC) and percutaneous trans-hepatic drainage of gallbladder (PTGBD) as an initial intervention for AC and to compare operative outcomes of ELC and delayed laparoscopic cholecystectomy (DLC).

Methods: English-language studies published until December 2020 were searched. Randomised controlled trials (RCTs) and observational studies compared EC and PTGBD with delayed cholecystectomy for patients presented with acute cholecystitis were considered. Read More

Cureus 2022 Apr 16;14(4):e24187. Epub 2022 Apr 16.

Radiology and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, IND.

Mirizzi and Bouveret syndromes are uncommon but important complications of calculous cholecystitis. Mirizzi syndrome commonly presents with jaundice due to extrinsic compression on the common bile duct by an impacted stone at the gall bladder infundibulum, whereas Bouveret syndrome presents with gastric outlet obstruction due to a large stone in the duodenum. Our case is a 65-year-old lady who presented with pain in the right upper abdomen associated with nausea and vomiting. Read More

J Nucl Med 2022 May 19. Epub 2022 May 19.

University Medical Center Utrecht, Netherlands.

Hepatocellular carcinoma (HCC) is the sixth most common cancer and second in cancer-related deaths. Radioembolization using holmium-166 (Ho)-microspheres is new in the HCC treatment landscape. Safety and efficacy of Ho-radioembolization was first determined in the HEPAR and HEPAR II studies, however excluding patients with HCC. Read More

Indian J Pediatr 2022 May 19. Epub 2022 May 19.

Department of Pediatrics, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.

J Interv Med 2022 Feb 10;5(1):10-14. Epub 2021 Dec 10.

Department of Interventional Radiology, Nanjing Medical University Third School of Clinical Medicine, Nanjing First Hospital, Nanjing, Jiangsu, 210006, China.

Objective: To compare the safety of conventional transarterial chemoembolization (cTACE) vs drug-eluting bead TACE (DEB-TACE) in very early- and early-stage hepatocellular carcinoma (HCC).

Methods: Data of patients with early- and very early-stage HCC treated with cTACE or DEB-TACE were evaluated retrospectively in this study. A total of 40 patients were included, 20 treated with cTACE and 20 with DEB-TACE. Read More

Surg Case Rep 2022 May 18;8(1):97. Epub 2022 May 18.

Department of Surgery, Doshinkai Tohyama Hospital, Minami-Shinmachi 17-22, Tsu, Mie, 514-0043, Japan.

Background: Ceftriaxone, a third-generation cephalosporin antibiotic with a long plasma half-life, is widely used to treat various infections. The use of ceftriaxone can sometimes induce biliary sludge or stone formation. Although most cases of ceftriaxone-induced pseudolithiasis are asymptomatic or mild and resolve with discontinuation of the drug, we experienced an elderly case of severe acute necrotizing calculous cholecystitis after administration of ceftriaxone. Read More

Am Surg 2022 May 16:31348221102610. Epub 2022 May 16.

Deptartment of Surgical Gastroenterology, 442339All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

The Immunoglobulin G4-related disease (IgG4-RD) is a multisystem inflammatory condition. Pancreaticobiliary manifestations often present as mass lesions that mimic malignancies. The diagnosis is confirmed by histopathological examination, that shows lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and positive immunohistochemistry for IgG4. Read More

J Am Anim Hosp Assoc 2022 May;58(3):146-151

From Dick White Referrals, Cambridgeshire, United Kingdom.

Anicteric gallbladder rupture has been rarely described in veterinary medicine, and, generally, it has been related to gallbladder wall necrosis secondary to gallbladder mucocele. A 5 yr old, male, neutered Labrador retriever presented for acute onset anorexia, lethargy, and vomiting. Cholecystitis was diagnosed based on the ultrasonographic findings and bactibilia, and, consequently, medical treatment was established. Read More

Cureus 2022 Apr 13;14(4):e24101. Epub 2022 Apr 13.

Trauma and Acute Care Surgery, Methodist Health System, Dallas, USA.

Cholecystocolonic fistula (CCF) is a rare complication of biliary tract disease. Increased use of imaging has aided in diagnosing these fistulae preoperatively and has established laparoscopy as a safe alternative to laparotomy. Here, we present a 79-year-old male who presented to the emergency room with abdominal pain and was diagnosed with choledocholithiasis. Read More

Radiol Case Rep 2022 Jul 5;17(7):2309-2314. Epub 2022 May 5.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

A 72-year-old female without abdominal symptoms visited our hospital for routine follow-up while undergoing pancreatic cancer treatment (using TS-1). Her vital signs were normal, and her abdomen was soft and non-tender. Blood test revealed elevated C-reactive protein levels with normal white blood cell count. Read More

Eur J Med Res 2022 May 15;27(1):68. Epub 2022 May 15.

Suining Central Hospital, 127 Desheng West Road, Chuanshan, Suining, 629000, Sichuan, China.

Background: Dermatomyositis is a rare idiopathic inflammatory disease with diverse presentations that can have varying degrees of cutaneous and systemic involvement. This phenotypic heterogeneity makes DM a therapeutic challenge. Some therapeutic drugs, such as hormones and immunosuppressants, have poor therapeutic effects. Read More

Emerg Radiol 2022 May 14. Epub 2022 May 14.

Division of Surgery, Fujinomiya City General Hospital, 3-1, Nishiki-cho, Fujinomiya, Shizuoka, 4180076, Japan.

Purpose: Gangrenous cholecystitis (GC) is a severe type of acute cholecystitis that implies higher mortality and morbidity rates than uncomplicated cholecystitis. The characteristics of GC are various for each case. However, preoperative predictors of GC with extensive necrotic change have not been investigated well. Read More

Vet Med Sci 2022 May 13. Epub 2022 May 13.

Department of Veterinary Medicine, University of Bari "Aldo Moro", Bari, Italy.

Mucocele and cholecystitis were diagnosed in a 10 year-old Shetland-sheepdog presenting aspecific clinical signs. Blood examinations and ultrasonography investigation were performed before to surgical approach, which allowed to collect biopsies and samples for bacteriological analyses. In addition, the patient was subjected to cholecystectomy. Read More

Cureus 2022 Apr 11;14(4):e24048. Epub 2022 Apr 11.

Gastroenterological Surgery, Osaka Saiseikai Noe Hospital, Osaka, JPN.

Neurofibromatosis type 1 (NF1) is a congenital condition characterized by "café au lait" spots and subcutaneous fibromas. There are various combined diseases, such as malignant tumors in the abdominal organs or brain tumors. Here, we present a case of a 35-year-old patient with a rare combination of NF1 with a gastrointestinal stromal tumor (GIST) and pancreaticobiliary maljunction (PBM). Read More

J Coll Physicians Surg Pak 2022 May;32(5):662-664

Department of Pediatrics, Division of Pediatric Infectious Diseases, Balikesir Ataturk City Hospital, Balikesir, Turkey.

Epstein-Barr Virus (EBV) is a herpes virus with a high seropositivity rate among the adult population throughout the world. Primary EBV infection is usually asymptomatic among young children. As age increases, it begins to manifest as infectious mononucleosis. Read More

BMJ Open 2022 May 11;12(5):e048242. Epub 2022 May 11.

School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Purpose: To investigate the potential causal link between heredity, geographical environment, diet and other lifestyle factors with long-term health consequences, we established the Xinjiang Multiethnic Cohort Study (XMC), the first large-scale prospective cohort in Xinjiang, China.

Participants: XMC commenced in 2018 and enrolled participants from three study sites (Urumqi, Hotan and Ili) in Xinjiang, China. Data collected include standard baseline questionnaire, physical measurement, biological specimen. Read More

BMC Surg 2022 May 10;22(1):168. Epub 2022 May 10.

Department of General, Visceral, Vascular and Transplant Surgery, University Hospital Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

Background: The COVID-19 pandemic caused a global health crisis in 2020. This pandemic also had a negative impact on standard procedures in general surgery. Surgeons were challenged to find the best treatment plans for patients with acute cholecystitis. Read More

Cureus 2022 Apr 7;14(4):e23920. Epub 2022 Apr 7.

Department of Radiology, University College Hospital, Ibadan, NGA.

Introduction And Aim: Diabetes mellitus (DM) is one of the most common non-communicable diseases worldwide. Diabetics with autonomic neuropathy tend to have larger gallbladder (GB) with poor contraction after fatty meals predisposing them to gallstones and cholecystitis. This may be prevented and treated if detected early using ultrasound. Read More

Cureus 2022 Apr 7;14(4):e23917. Epub 2022 Apr 7.

Department of Cardiothoracic Surgery, The Essex Cardiothoracic Centre, Basildon & Thurrock University Hospital, Mid and South Essex NHS Foundation Trust, Basildon, GBR.

A pericardial cyst is a rare and benign cause of a mediastinal mass. They are frequently asymptomatic and are usually incidental findings on imaging. Symptoms may include persistent cough, atypical chest pain, dysphagia, and dyspnea. Read More

Cureus 2022 Apr 3;14(4):e23773. Epub 2022 Apr 3.

Surgery, Government Hospital Ghaziabad, Lahore, PAK.

Background Chronic cholecystitis is inflammation of the gall bladder usually caused by stones. The aim was to find out the prevalence of mucocele and empyema in chronic cholecystitis using cholecystectomy findings and histopathological reports. Methodology This was a cross-sectional observational study conducted in Surgical Ward 1, Jinnah Postgraduate Medical Center, Karachi from December 2019 to December 2021 for two years. Read More

Am J Case Rep 2022 May 8;23:e936329. Epub 2022 May 8.

Department of General Surgery, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China (mainland).

BACKGROUND Clostridium perfringens (CP), one of several clostridial species gram-positive bacteria, is a major cause of animal necrosis enteritis and traumatic gangrene. In some reports, CP can cause acute emphysematous cholecystitis in patients with biliary tract infections. However, C. Read More

Int J Surg 2022 May 4;102:106649. Epub 2022 May 4.

Hospital General Universitario de Alicante, Spain.

Background: Being able to predict preoperatively the difficulty of a cholecystectomy can increase safety and improve results. However, there is a need to reach a consensus on the definition of a cholecystectomy as "difficult". The aim of this study is to achieve a national expert consensus on this issue. Read More

Cureus 2022 Apr 4;14(4):e23801. Epub 2022 Apr 4.

Pediatric Surgery, West Virginia University School of Medicine, Morgantown, USA.

Gallbladder volvulus is a rare gallbladder pathology that can present in adults but is exceedingly rare in children. The diagnosis itself can be very challenging due to its presentation with signs and symptoms of acute cholecystitis without specific imaging findings. The correct identification and prompt intervention with a cholecystectomy are crucial to improve patient outcomes. Read More

BJS Open 2022 May;6(3)

Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Manchester, UK.

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic.

Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Read More

Pharmacotherapy 2022 May 4. Epub 2022 May 4.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Study Objective: Clinical trials have suggested that glucagon-like peptide-1 receptor agonists (GLP-1RAs) may be associated with a higher risk of biliary-related diseases in patients with type 2 diabetes. Limited real-world studies have examined the comparative biliary safety of GLP-1RAs versus other antihyperglycemic drugs. We aimed to estimate the comparative risk of biliary-related diseases between GLP-1RAs and sodium glucose cotransporter 2 inhibitors (SGLT2is), which are indicated for patients with similar diabetes severity in Taiwan. Read More

Surg Endosc 2022 May 4. Epub 2022 May 4.

Laparoscopic Biliary Service, University Hospital Monklands, Monkscourt Avenue, Airdrie, Lanarkshire, ML6 0JS, Scotland, UK.

Background: The timing of laparoscopic cholecystectomy (LC) for emergency biliary admissions remains inconsistent with national and international guidelines. The perception that LC is difficult in acute cholecystitis and the popularity of the two-session approach to pancreatitis and suspected choledocholithiasis result in delayed management.

Methods: Analysis of prospectively maintained data in a unit adopting a policy of "intention to treat" during the index admission. Read More

Asian J Endosc Surg 2022 May 3. Epub 2022 May 3.

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.

Background: Tokyo Guidelines 2018, clinical practice guidelines for acute cholangitis and cholecystitis, recommend bailout procedures to prevent bile duct injury (BDI) during laparoscopic cholecystectomy (LC) for difficult gallbladder. We first insert an additional port (AP) for difficult gallbladder that may require bailout procedures. Because the usefulness of an AP during LC is unclear, we therefore examined the efficacy of the AP during LC in this study. Read More

Am J Surg 2022 Apr 29. Epub 2022 Apr 29.

Trauma Unit Shamir Medical Center Affiliated with University Tel Aviv, Zerefin, Israel. Electronic address:

Front Surg 2022 12;9:871685. Epub 2022 Apr 12.

Department of General, Laparoscopic, Oncologic and Robotic Surgery, Athens Medical Center, Athens, Greece.

Introduction: Since the beginning of the COVID-19 pandemic, many patients with clinically acute presentations have been approached differently. The fear of viral transmission along with the short period of study made patients delay their hospital visits and doctors reassess the approach of certain acute situations. This study aimed to assess the changes in the management of patients with acute cholecystitis before and during COVID-19. Read More