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IDCases 2019 29;15:e00498. Epub 2019 Jan 29.

Department of Gastroenterology, Tosei General Hospital, Seto, Aichi, Japan.

Introduction: is a gram-negative, catalase-positive, oxidase-negative, aerobic fermentative bacterium with flagella. This organism colonizes in the human body and its pathogenicity is extremely low; few clinical cases of infection have been reported.

Presentation Of Case: We report on a patient who experienced severe sepsis and acute cholangitis due to bacteremia and was treated with levofloxacin following antibiotic susceptibility testing. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):1-3

Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. Read More

Clin Res Hepatol Gastroenterol 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris AP-HP, Sorbonne university, 75012 Paris, France. Electronic address:

Background: The aim of this study was to identify predictive criteria of improvement after endoscopic treatment (ET) for severe strictures of extrahepatic bile ducts in patients with primary sclerosing cholangitis (PSC).

Methods: PSC patients who had at least one ET for severe stricture were included. Features of magnetic resonance cholangiography (MRC), performed before ET, were evaluated according to a standard model of interpretation, and a radiologic qualitative score of probability of improvement after ET was built. Read More

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

J Feline Med Surg 2019 Jan;21(1):12-24

Radiology Department, Willows Veterinary Centre and Referral Service, Highlands Road, Shirley, Solihull B90 4NH, UK.

Practical Relevance:: Abdominal ultrasound plays a vital role in the diagnostic work-up of many cats presenting to general and specialist practitioners. Ultrasound examination of the liver can be key in the diagnosis of diseases such as hepatic lipidosis and hepatic neoplasia.

Clinical Challenges:: Despite ultrasonography being a commonly used modality, many practitioners are not comfortable performing an ultrasound examination or interpreting the resulting images. Read More

Eur J Clin Invest 2019 Feb 14:e13088. Epub 2019 Feb 14.

Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom.

Background: Cholangiocarcinoma (CCA) complicates primary sclerosing cholangitis (PSC) in 10-20% of cases, but current tools for prediction of a CCA diagnosis are inadequate. Recently we demonstrated the utility of the ELF test to stratify prognosis in PSC. We observed that patients with PSC+CCA had significantly higher ELF score than those with PSC alone. Read More

Gut 2019 Feb 13. Epub 2019 Feb 13.

Department of Gastroenterology and Hepatology, Kansai Electric Power Hospital, Osaka, Japan.

J Ultrasound 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, "Federico II" University Hospital, Naples, Italy.

Paediatric biliary tract and gallbladder diseases include a variety of entities with a wide range of clinical presentations. Cholestasis represents an impaired secretion of bilirubin by hepatocytes, manifesting with high blood levels of conjugated bilirubin and jaundice. Various causes may be involved, which can be recognised analysing blood tests and hepatobiliary imaging, while sometimes liver biopsy or surgery may be necessary. Read More

J Med Case Rep 2019 Feb 13;13(1):33. Epub 2019 Feb 13.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 〒480-1195 1-1 Yazakokarimata, Nagakute, Aichi, Japan.

Background: Pantoea is a Gram-negative, non-encapsulated, non-spore-forming, ubiquitous straight rod which can be isolated from geographical and ecological sources such as plant surfaces, buckwheat seeds, human feces, and the environment. The genus Pantoea is a rare pathogen in a clinical setting, and is divided into 20 different species such as Pantoea agglomerans, Pantoea ananatis, Pantoea deleyi, Pantoea dispersa, Pantoea septica, Pantoea stewartii or Pantoea rwandensis. Pantoea dispersa has been reported to cause other infections, including respiratory infections, neonatal sepsis, and bloodstream infections. Read More

J Clin Densitom 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA. Electronic address:

Osteoporosis is the most common bone disease in chronic liver disease (CLD) resulting in frequent fractures and leading to significant morbidity in this population. In addition to patients with cirrhosis and chronic cholestasis, patients with CLD from other etiologies may be affected in the absence of cirrhosis. The mechanism of osteoporosis in CLD varies according to etiology, but in cirrhosis and cholestatic liver disease it is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Read More

Eur J Gastroenterol Hepatol 2019 Feb 7. Epub 2019 Feb 7.

Catalyst Medical Consulting, Simpsonville.

Objective: Acute cholangitis (AC) and upper gastrointestinal hemorrhage (UGIH) are common emergencies encountered by gastroenterologists. We aimed to evaluate the impact of UGIH on in-hospital mortality, morbidity and resource utilization among patients with AC.

Patients And Methods: Adult admissions with a principal diagnosis of AC were selected from the National Inpatient Sample 2010-2014. Read More

Aliment Pharmacol Ther 2019 Feb 10. Epub 2019 Feb 10.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.

Background: After liver transplantation primary sclerosing cholangitis (PSC), the condition returns in the transplanted liver in a subset of patients (recurrent primary sclerosing cholangitis, rPSC).

Aim: To define risk factors for rPSC.

Methods: We searched Pubmed, Embase, Web of Science, and Cochrane library for articles published until March 2018. Read More

Hepatology 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

In Japan, bezafibrate (BF) is a second-line agent for primary biliary cholangitis (PBC) that is refractory to ursodeoxycholic acid (UDCA) treatment. From a retrospective cohort (n=873) from the Japan PBC Study Group, we enrolled 118 patients who had received UDCA monotherapy for ≥1 year followed by combination therapy with UDCA+BF for ≥1 year. GLOBE and UK-PBC scores after UDCA monotherapy (that is, immediately before UDCA+BF combination therapy) were compared with those after 1 year of UDCA+BF combination therapy. Read More

Liver Int 2019 Feb 8. Epub 2019 Feb 8.

Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre,, Newcastle University, Newcastle upon Tyne, United Kingdom.

Background &aims: Pruritus is a common symptom in patients with primary biliary cholangitis (PBC) for which ileal bile acid transporter (IBAT) inhibition is emerging as a potential therapy. We explored the serum metabonome and gut microbiota profile in PBC patients with pruritus and investigated the effect of GSK2330672, an IBAT inhibitor.

Methods: We studied fasting serum bile acids (BAs), autotaxin and faecal microbiota in 22 PBC patients with pruritus at baseline and after two weeks of GSK2330672 treatment. Read More

PLoS One 2019 8;14(2):e0211906. Epub 2019 Feb 8.

Seaman Family MR Research Centre, University of Calgary, Calgary, Alberta, Canada.

Background: Many patients with primary biliary cholangitis (PBC) experience non-hepatic symptoms that are possibly linked to altered interoception, the sense of the body's internal state. We used magnetic resonance imaging (MRI) to determine if PBC patients exhibit structural and functional changes of the thalamus and insula, brain regions that process signals related to interoception.

Methods: Fifteen PBC patients with mild disease and 17 controls underwent 3 Tesla T1-weighted MRI, resting-state functional MRI, and quantitative susceptibility mapping (QSM), to measure thalamic and insular volume, neuronal activity and iron deposition, respectively. Read More

NMR Biomed 2019 Feb 8:e4065. Epub 2019 Feb 8.

University of Manitoba, Winnipeg, Manitoba, Canada.

Primary sclerosing cholangitis (PSC) has been considered to be either an "autoimmune disease" or a "bile acid-induced injury." In vitro MRS studies on PSC patients have limitations due to the contamination of bile with contrast agent (commonly administered during endoscopic retrograde cholangiopancreatography) and/or the use of patient cohorts with other diseases as controls. The objective of this study was to quantify biliary metabolites using in vivo H MRS and gain insight into the pathogenesis of PSC. Read More

Medicine (Baltimore) 2019 Feb;98(6):e13640

Rationale: Coils migration following endovascular treatment of arterial bleeding is rare. There was no clear route to deal with this complication.

Patient Concerns: A 55-year-old woman underwent choledochal cyst excision with hepaticojejunostomy. Read More

Int J Surg Case Rep 2019 Jan 30;55:140-144. Epub 2019 Jan 30.

Second Department of Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan.

Introduction: Acquired inhibition of coagulation factors is a rare disease, and the diagnosis is often difficult and delayed. We experienced a deficiency in all coagulation factors after hepatobiliary surgery.

Case Presentation: Extended left liver resection was undertaken and hepaticojejunostomy was performed in a 70-year-old man. Read More

Am J Gastroenterol 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with no effective medical therapies. A perturbation of the gut microbiota has been described in association with PSC, and fecal microbiota transplantation (FMT) has been reported to restore the microbiome in other disease states. Accordingly, we aimed at evaluating the safety, change in liver enzymes, microbiota, and metabolomic profiles in patients with PSC after FMT. Read More

Curr Opin Crit Care 2019 Feb 5. Epub 2019 Feb 5.

Purpose Of Review: To review recent literature on the management of patients with severe acute pancreatitis (SAP) admitted to an ICU.

Recent Findings: SAP is a devastating disease associated with a high morbidity and mortality. Recent evidence advocates adequate risk assessment and severity prediction (including intra-abdominal pressure monitoring), tailored fluid administration favoring balanced crystalloids, withholding prophylactic antibiotic therapy, and early detection and treatment of extra-pancreatic and fungal infections. Read More

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Suite 7717, 85 E Concord St, Boston, MA, 02118, USA.

Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. Read More

Acta Radiol 2018 Jan 1:284185118784978. Epub 2018 Jan 1.

2 Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Kupffer cells (KC) have an important role in the host defense in obstructive cholangitis. Non-invasive monitoring of phagocytic function of KC is pivotal. Several studies showed the possibility of non-invasive monitoring of phagocytic function of KC using superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI) or contrast-enhanced ultrasound (CEUS). Read More

Hepatology 2019 Feb 5. Epub 2019 Feb 5.

Research, Central Texas Veterans Health Care System, Temple, TX, USA.

Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract. Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly influence the surrounding liver tissue by secretion of signaling molecules. One way in which cells can interact is through secretion of extracellular vesicles (EVs), which are small membrane-bound vesicles, containing proteins, miRNAs and cytokines. Read More

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China.

Background: Primary biliary cholangitis (PBC) is an organ-specific, T cell mediated autoimmune disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, especially the pyruvate dehydrogenase E2 complex (PDC-E2). However, the molecular mechanism of breakdown of self-tolerance is still unclear.

Methods: A combination of multiplex-PCR and immune repertoire sequencing (IR-seq) was used for a standardized analysis of memory T cell receptor (TCR) β-chain repertoire of PBC patient and healthy volunteers. Read More

Surg Laparosc Endosc Percutan Tech 2019 Feb 1. Epub 2019 Feb 1.

Department of General Surgery, Konak Hospital, Gebze, Kocaeli, Turkey.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) has been commonly used for biliopancreatic diseases of patients with normal gastrointestinal (GI) anatomy with a success rate of >90%. However, this procedure may also be necessary in patients with altered GI anatomy such as Billroth II or Roux-en-Y reconstructions. Performing ERCP in these patients may pose extreme technical challenges, and increase the risk of complications. Read More

Transplantation 2019 Jan 30. Epub 2019 Jan 30.

Department of Transplant Surgery, Jichi Medical University.

Background: We present retrospective analysis of our 15-year experience with pediatric living donor liver transplantation (LDLT), focusing on the risk factors, treatments and long-term prognosis for post-transplant biliary complications (BCs).

Methods: Between May 2001 and December 2017, 290 LDLTs were performed. The median age was 1. Read More

BMC Surg 2019 Feb 4;19(1):16. Epub 2019 Feb 4.

Department of Hepatobiliary and Pancreatic surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: To evaluate the perioperative and long-term results of intrahepatic bile duct exploration lithotomy (IHBDIL) combined with hepatectomy for patients with complicated bilateral primary hepatolithiasis.

Methods: A study was conducted involving 56 patients with complicated bilateral primary hepatolithiasis who underwent IHBDIL combined with hepatectomy at our hospital from January 2006 to December 2014. The perioperative and long-term outcomes that were retrospectively analysed included the stone clearance rate, operative morbidity and mortality, and stone recurrence rate. Read More

J Anim Physiol Anim Nutr (Berl) 2019 Feb 3. Epub 2019 Feb 3.

Department of Animal and Poultry Production, Faculty of Agriculture, Damanhour University, Damanhour, Egypt.

Sixty-four nulliparous female rabbits were distributed among eight groups (eight animals/group). Group one was the unsupplemented control group; the other seven groups were supplemented with zinc bacitracin (ZnB) at 100 mg, or bee pollen (BP) and/or propolis (Pro) at 150 and 300 mg in a capsulated form, three times a week, day after day, continuously all over the experimental period. The experiment was run for eight parties; at each parity, 28 kids of each doe group (a total of 224 rabbits) were divided into two subgroups weaned, respectively, at 24 and 30 days of age. Read More

Endocr J 2019 Feb 2. Epub 2019 Feb 2.

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Primary sclerosing cholangitis (PSC) has been known as a cause of secondary osteoporosis, which often requires medication. Herein, we give the first report of a case of a 38-year-old man with fatigue and paralysis in both upper limbs who had been treated with denosumab for secondary osteoporosis associated with PSC. Since bisphosphonate (alendronate) was ineffective in our patient, the treatment was changed from alendronate to denosumab. Read More

J Autoimmun 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address:

Background And Aims: The most highly directed and specific autoantibody in human immunopathology is the serologic hallmark of primary biliary cholangitis (PBC), antimitochondrial antibodies (AMAs). However the clinical significance of finding a positive AMA, with normal alkaline phosphatase (ALP) remains enigmatic.

Methods: We took advantage of 169 consecutive outpatients who were identified as having a positive AMA, but normal ALP levels between January 2012 and January 2018. Read More

World J Gastrointest Endosc 2019 Jan;11(1):41-53

Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30303, United States.

Aim: To assess the effect of early late endoscopic retrograde cholangiopancreatography (ERCP) on mortality and readmissions in acute cholangitis, using a nationally representative sample.

Methods: We used the 2014 National Readmissions Database to identify adult patients hospitalized with acute cholangitis who underwent therapeutic ERCP within one week of admission. Early ERCP was defined as ERCP performed on the same day of admission or the next day (days 0 or 1, < 48 h), and late ERCP was performed on days 2 to 7 of admission. Read More

World J Hepatol 2019 Jan;11(1):19-36

Department of Pediatrics, University of Utah, Salt Lake City, UT 84113, United States.

Primary sclerosing cholangitis (PSC) is a rare disease of stricturing and destruction of the biliary tree with a complex genetic and environmental etiology. Most patients have co-occurring inflammatory bowel disease. Children generally present with uncomplicated disease, but undergo a variable progression to end-stage liver disease. Read More

Ter Arkh 2018 Aug;90(8):107-112

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Faculty of Medicine, Chair of Internal Medicine No.1.

The primary autoimmune liver diseases conventionally include primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis. Despite of primary autoimmune affection of different parts of the hepatobiliary system, in the recent decades, a lot of data has emerged indicating the presence of extrahepatic manifestations of these diseases, in particular, lung lesions, such as nodular and interstitial changes with possible progression and development of fibrosis and respiratory failure. In case of lungs disease, both pulmonary parenchyma and lung vessels, pleura, and intrathoracic lymph nodes can be involved. Read More

Ter Arkh 2018 Apr;90(3):4-9

Scientific research Institute pulmonology Federal medical and biological Agency, Moscow, Russia.

Diseases associated with disorders of immunoglobulin g synthesis and its subclasses are described. The analysis of the role of both deficiency and its increased production in the diagnosis and treatment of a number of diseases in humans. Read More

J Dig Dis 2019 Jan 31. Epub 2019 Jan 31.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: Autoimmune pancreatitis (AIP) was autoimmune disorder accompanied by clinicopathological manifestation whose concept was established as IgG4-related disease (IgG4-RD). Other IgG4-RDs are often involved with autoimmune pancreatitis, sometimes relapsing despite the favorable response to a steroid therapy. This study aimed to clarify patterns and risk factors for extrapancreatic relapse. Read More

J Clin Med Res 2019 Feb 5;11(2):81-88. Epub 2019 Jan 5.

Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.

Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tract. PSC is strongly associated with inflammatory bowel disease (IBD), mainly with ulcerative colitis, and most PSC patients have underlying IBD. The pathophysiological interactions between IBD and PSC are unclear, although it seems that the patients with IBD and PSC have a distinct phenotype. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1818-1820

Dept. of Surgery, Numazu City Hospital.

An 87-year-oldwoman was admittedto our hospital with abdominal pain andfever. Computedtomography showeda 25 mm tumor mass in the pancreatic headandshowedd ilatation of the pancreatic duct andcommon bile duct. She was diagnosed with obstructive cholangitis due to pancreatic head cancer. Read More

Hepatol Res 2019 Jan 28. Epub 2019 Jan 28.

Division of Advanced Genome Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Aim: Primary biliary cholangitis (PBC) is an autoimmune liver disease with unknown pathogenesis. In PBC, activation of T cell receptor (TCR) signaling is associated with inflammatory cytokine production via N-Ras upregulation. Although CD4 T cell TCR repertoire may be associated with PBC pathogenesis, it has not been evaluated. Read More

Aliment Pharmacol Ther 2019 Feb;49(4):472-473

Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Aliment Pharmacol Ther 2019 Feb;49(4):473-474

Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Aliment Pharmacol Ther 2019 Jan 27. Epub 2019 Jan 27.

Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.

Background: Primary sclerosing cholangitis is associated with an increased risk of biliary tract cancer. Carbohydrate antigen 19-9 (CA19-9) can be used to screen for these malignancies.

Aim: To perform a longitudinal analysis of CA19-9 in patients with primary sclerosing cholangitis. Read More

Curr Health Sci J 2018 Apr-Jun;44(2):186-191. Epub 2018 Mar 27.

University of Oradea, Faculty of Medicine and Pharmacy.

Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. Read More

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):73-76

Department of Digestive Disease, Xijing Hospital, the Military Medical University of Air Force PLA, Xi'an 710032, China.

Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease. Ursodeoxycholic acid (UDCA) is a first-line drug approved by the Food and Drug Administration for the treatment of PBC. It can effectively improve serum biochemical indicators, delay histological progress, and prolong the survival of non-transplant patients. Read More

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):14-17

Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine;Institute of Digestive Disease, Shanghai 200001, China.

Autoimmune liver disease is a group of hepatobiliary injuries mediated by abnormal immunity. It mainly includes autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Recently, an advancement of diagnostic technology has improved the detection and treatment of autoimmune hepatitis. Read More

J Allergy Clin Immunol 2019 Jan 22. Epub 2019 Jan 22.

Laboratory of Childhood Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, and Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Liver disease in X-linked hyper IgM syndrome (XHIGM) is an important predictor of mortality. In case liver transplantation (LT) is required, a survival benefit is observed when LT is combined with HSCT. Read More

J Clin Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT.

Introduction: Endoscopic retrograde cholangiopancreatography is the preferred method in biliary drainage. Endoscopic ultrasound (EUS) guidance has shown tremendous success in situations where endoscopic retrograde cholangiopancreatography fails or is contraindicated. EUS-guided choledochoduodenostomy (CDD) in particular is gathering a lot of interest due to its ease, and high rates of success. Read More

Am J Gastroenterol 2019 Feb;114(2):361-362

French Reference Center for Inflammatory Biliary Diseases (MIVB) and French Network for Rare Liver Diseases (FILFOIE), Saint-Antoine Hospital, Paris, France.

J Med Case Rep 2019 Jan 24;13(1):21. Epub 2019 Jan 24.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.

Background: In this report, we present the results of a severe case of Sjögren's syndrome-related keratopathy after fluocinolone acetonide 190-μg intravitreal implant (Iluvien®; Alimera Sciences Inc.) therapy.

Case Presentation: A 52-year-old Caucasian woman with Sjögren's syndrome secondary to autoimmune hepatitis and primary sclerosing cholangitis was admitted to our emergency department owing to bilateral corneal ulcers and corneal perforation in the left eye following exposure keratopathy in an artificially induced coma. Read More