Search Our Scientific Publications & Authors

J Surg Res 2019 Apr 21;241:95-102. Epub 2019 Apr 21.

Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Postsurgical biliary disease in Roux-en-y and cholecystectomies has been investigated, but less literature exists regarding biliary complications after Whipple procedure (pancreaticoduodenectomy [PD]). Moreover, the hospital burden incurred after this complication has not been previously examined. The aim of this study is to assess the trends in hospitalization for biliary strictures and cholangitis after PD. Read More

Methods Mol Biol 2019 ;1981:363-372

Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

Cholangiopathies, including primary sclerosing cholangitis, are a group of heterogeneous diseases characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile duct epithelium. Studies, especially of primary sclerosing cholangitis, have been hampered by the difficulty in accessing the cholangiocyte, instability of in vitro culture systems, and reliance on (limited) samples from end-stage disease. Here we describe a novel method of culturing biliary cells from bile of primary sclerosing cholangitis patients undergoing endoscopic retrograde cholangiopancreatography for clinical indications. Read More

Methods Mol Biol 2019 ;1981:249-257

Liver Unit, Hospital Clínic de Barcelona, Institut D'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain.

Liver cholestasis is characterized by impairment in bile flow. Among cholestatic diseases, primary biliary cholangitis and primary sclerosing cholangitis represent relevant causes of chronic liver disease, associated to significant morbidity and mortality. To better understand and to address therapeutic strategies to cholangiopathies is essential to develop an in vivo model which recapitulates the pathological features of the disease. Read More

Methods Mol Biol 2019 ;1981:237-247

Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Cholestatic liver disease covers a range of biliary disorders marked by an impaired bile duct flow. Various conditions can result in bile obstruction including choledocholithiasis, surgical trauma, and autoimmune disorders. Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. Read More

Methods Mol Biol 2019 ;1981:163-173

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Primary biliary cholangitis is a chronic cholestatic liver disease characterized by the presence of serum antimitochondrial antibodies and immune-mediated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated. In recent years, proteomics has been comprehensively applied in many research fields, including the pathogenesis, prognosis, and diagnosis of disease. Read More

Case Rep Gastrointest Med 2019 19;2019:8038469. Epub 2019 Mar 19.

Department of Internal Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.

Gallstone disease is a common gastrointestinal pathology that may result in surgical intervention. While cholecystectomy has relatively minimal risks, surgical clip migration is a rare complication that can cause severe morbidity and mortality. This report describes a rare phenomenon of a biliary stone forming onto a migrated surgical clip 14 years after cholecystectomy causing an obstructive jaundice. Read More

Radiol Case Rep 2019 Jul 15;14(7):800-804. Epub 2019 Apr 15.

Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen, 9700 RB, The Netherlands.

We report the case of a 16-year-old boy with primary clerosing holangitis associated with inflammatory bowel disease who was initially treated and controlled pharmacologically. He underwent living donor liver transplantation (LDLT) after he developed progressive biliary tract abnormalities and portal hypertension accompanied by recurrent bile duct infections. Two months following LDLT, the hepaticojejunostomy anastomosis became occluded and it was treated surgically. Read More

Rev Gastroenterol Mex 2019 Apr 20. Epub 2019 Apr 20.

Unidad de Cirugía General y Hepatobiliar, Departamento de Cirugía Abdominal, Ente Ospedaliero Ospedali Galliera, Génova, Italia.

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.

Primary sclerosing cholangitis (PSC) is characterized by progressive fibrosis around intra- and extrahepatic bile ducts that can progress to cirrhosis and liver failure. There are no regulatory drugs approved for PSC and liver transplantation is the only effective therapy(1). While the concentric accumulation of periductular fibrosis suggests the biliary epithelial cell (cholangiocyte) plays an integral role in disease initiation and/or progression, multiple factors from the gut like microbes and their molecular products, endogenous metabolites like bile acids, and primed immune cells have been hypothesized to play a significant role in the hepatobiliary injury and adverse clinical sequelae in PSC. Read More

Case Rep Gastroenterol 2019 Jan-Apr;13(1):113-117. Epub 2019 Mar 5.

Department of Gastroenterology and Hepatology, Tokai University School of Medicine, Kanagawa, Japan.

A 49-year-old man was referred to our hospital for an abnormality of the hepatobiliary enzyme. The patient was diagnosed with primary sclerosing cholangitis 9 years ago, and he had a biliary stent with a string placed as an inside stent. We attempted to remove the stent 6 months later, but the string was cut off, so the stent could not be removed. Read More

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Patients suffering from cholestasis often report experiencing a debilitating, unrelenting itch. In contrast to conditions like urticaria in which histamine primarily drives itch (pruritus), cholestatic pruritus is multifactorial and more difficult to treat. Existing therapies are not always effective and exhibit undesirable side effect profiles. Read More

Curr Hepatol Rep 2019 7;18(1):115-126. Epub 2019 Mar 7.

Translational Gastroenterology Unit, Nuffield Department of Medicine, Level 5, John Radcliffe Hospital, University of Oxford, Headley Way, Headington, Oxford, OX3 9DU UK.

Purpose Of Review: Biologics are well established in the treatment of many immuno-inflammatory diseases including inflammatory bowel disease (IBD). However, although primary sclerosing cholangitis (PSC) is closely associated with IBD, the role of biologics in PSC remains uncertain. Many new biologics are becoming available to treat IBD, and this review aims to use the experience of biologics in PSC so far to guide more effective evaluation of emerging therapies in the future. Read More

Pan Afr Med J 2018 2;31:72. Epub 2018 Oct 2.

Service d'Hépato-Gastroentérologie de l'Hôpital Aritide Le Dantec, Dakar, Sénégal.

Hepatic impairment is common during hyperthyroidism. It is most often asymptomatic. Hyperthyroidism revealed by jaundice has been rarely described in the literature. Read More

Exp Ther Med 2019 May 27;17(5):4183-4189. Epub 2019 Mar 27.

Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China.

The aim of the present study was to explore the indications for and safety of orthotopic liver transplantation for polycystic liver disease (PLD). Orthotopic liver transplantation in 11 patients with PLD between May 2004 and September 2013 was retrospectively analyzed. Patient epidemiological, clinical and follow-up data were collected. Read More

Clin Radiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. Electronic address:

Acute biliary conditions include cholangitis, obstruction, and biliary leakage. All these conditions may lead to severe biliary sepsis, which can be life threatening. Infected obstructed cholangitis is a medical emergency that requires active medical therapy and early biliary decompression is recommended. Read More

Gut 2019 Apr 19. Epub 2019 Apr 19.

Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université, INSERM, Paris, France.

Objective: Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these patients. The aim of this study was to assess the fungal gut microbiota in patients with PSC.

Design: We analysed the faecal microbiota of patients with PSC and concomitant IBD (n=27), patients with PSC and no IBD (n=22), patients with IBD and no PSC (n=33) and healthy subjects (n=30). Read More

Lancet Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer Center of Lanzhou University, Lanzhou, China; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China. Electronic address:

Background: Endoscopic sphincterotomy is the established treatment for common bile duct stones. Balloon dilation offers an alternative. Prolonged dilation (300 s) with a 10 mm diameter balloon decreases the occurrence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Read More

Transpl Infect Dis 2019 Apr 19:e13097. Epub 2019 Apr 19.

Hepatobiliary Surgery and Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.

Endotipsitis is a rare but severe complication of transjugular intrahepatic portosystemic shunt (TIPS), a device widely used to treat portal hypertension in adults, but sparsely used in children. We report a case of endotipsitis in a 3-year-old child affected of biliary atresia. She underwent a Kasai procedure at 3 months of age but, although the bile flow was restored, she presented upper gastrointestinal bleeding due to portal hypertension 1. Read More

Front Immunol 2019 3;10:662. Epub 2019 Apr 3.

Liver Unit, Hospital Clínic, Institut D'Investigacions Biomèdiques August Pi i Sunyer, CIBERehd, University of Barcelona, Barcelona, Spain.

Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is present worldwide. Autoantibodies, in particular anti-mitochondrial antibodies (AMA) detected by indirect immunofluorescence assays or newer solid phase immunoassays can detect most, but not all individuals with PBC. Detection of antibodies to the anti-nuclear antigens sp100 and gp210 can identify additional PBC patients, but some seronegative patients remain, often resulting in delayed diagnosis and treatment. Read More

BMC Gastroenterol 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock.

Case Presentation: An 83-year-old woman was hospitalized for suspected gallstones. Read More

Radiology 2019 May;291(2):542-545

From the Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608.

History A 70-year-old man presented to the emergency department with fever, chills, rigors, and upper abdominal discomfort. Physical examination revealed jaundice and mild right upper quadrant tenderness. Laboratory tests revealed an increased C-reactive protein level of 133 mg/L (normal range, 0. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):345-348

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To explore the feasibility and to compare the merits and demerits of laparoscopic and endoscopic approach in removing common bile duct stones in patients with gastrojejunostomy after gastrectomy.

Methods: Between January 2012 and December 2016, 25 patients with common bile duct stones after gastrojejunostomy received laparoscopic or endoscopic treatment in our centers. They were divided into laparoscopic group and endoscopic group based on treatment approaches for common bile duct stones, including 15 patients in laparoscopic group and 10 in endoscopic group. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan.

A 72-year-old woman with primary biliary cholangitis was admitted to our hospital with heart failure with a preserved ejection fraction. An accidental right ventricular perforation that occurred during an endomyocardial biopsy precipitated cardiogenic shock. Despite successful surgical treatment, she demonstrated progressive hemodynamic deterioration, which was resistant to the administration of high-dose catecholamines. Read More

Exp Clin Transplant 2019 Apr 17. Epub 2019 Apr 17.

From the Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: We aimed to determine outcomes and predictors of intraoperative-detected portal vein thrombosis in liver transplant recipients.

Materials And Methods: We retrospectively analyzed 806 adult liver transplant recipients from Shiraz, Iran, to determine those with intraoperative-detected portal vein thrombosis. Patients with this complication were compared with age- and sex-matched patients without this complication. Read More

Klin Onkol 2019 ;32(2):143-151

Background: Immunoglobulin (Ig) G4 associated sclerosing cholangitis is a rare inflammatory disease of the biliary tract. Although it is a very progressive condition, it responds to steroid therapy. IgG4 associated sclerosing cholangitis can mimic pancreatic carcinoma, cholangiocarcinoma, and primary sclerosing cholangitis; therefore, it is very important to obtain a differential diagnosis. Read More

Minerva Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Hepatopancreatobiliary Surgery, Tianjin Medical University Second Hospital, Tianjin Medical University, Tianjin, China -

Introduction: EUS-Guided biliary drainage was used as an alternative method for patients who failed ERCP. In recent years, an increasing number of patients was treated with EUS-BD,but lack of data was available to value the efficacy and safety between EUS and ERCP. Therefore, a review was needed to evaluate the similarities and differences between the two methods and explored whether EUS-Guided biliary drainage could be considered as first-line treatment. Read More

J Antimicrob Chemother 2019 Apr 16. Epub 2019 Apr 16.

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität München, München, Germany.

Background: Cholangitis is a common complication after endoscopic retrograde cholangiography (ERC).

Objectives: To evaluate antimicrobial coatings for biliary plastic stents in relation to efficacy against biliary pathogens, drug release and toxicity.

Methods: Biliary plastic stents were prepared by coating using a polylactide drug carrier. Read More

Expert Opin Ther Targets 2019 Apr 16:1-12. Epub 2019 Apr 16.

a Indiana Center for Liver Research, Division of Gastroenterology & Hepatology, Department of Medicine , Indiana University School of Medicine , Indianapolis , IN , USA.

Introduction: The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understanding of the mechanisms and pathogenesis is needed to develop novel therapies. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15131

Department of Interventional treatment, Qinhuangdao Municipal No. 1 Hospital, No. 258 Wenhua Road, Qinhuangdao, Hebei Province, PR China.

Background: The in-hospital mortality rate in patients undergoing percutaneous transhepatic biliary drainage (PTBD) for malignant obstructive jaundice (MOJ) is high. There are few reports on the risk factors associated with hospital death after MOJ, with most of them being retrospective analyses of single factors. Therefore, this study aimed to assess pre-, intra-, and post-procedure risk factors that were independently associated with increased in-hospital mortality in MOJ patients who underwent PTBD. Read More

J Laparoendosc Adv Surg Tech A 2019 Apr 13. Epub 2019 Apr 13.

1 Department of Pediatric Surgery, Medical Faculty Mannheim, Heidelberg University, University Medical Center, Mannheim, Germany.

Purpose: There is a lack of experience with stenting for benign pancreaticobiliary disorders in children.

Materials And Methods: Fifteen children (9 male and 6 female) with a median age of 7.1 years (range 0. Read More

Hepatology 2019 Apr 15. Epub 2019 Apr 15.

Department of Microbiology and Immunology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA.

Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte-derived exosomal-long non-coding RNA-H19 (LncRNA-H19) plays a critical role in promoting cholestatic liver injury. However, it remains unclear whether cholangiocyte-derived lncRNA-H19 regulates HSC activation, which is the major focus of this study. Read More

Balkan J Med Genet 2018 Dec 31;21(2):49-53. Epub 2018 Dec 31.

Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.

We report the case of a 41-year-old man on conservative treatment for more than 20 years for chronic renal insufficiency, chronic hepatitis and recurrent cholangitis. Following lengthy and extensive diagnostics, the differential diagnosis included primary sclerosing cholangitis and Caroli's disease (CD). To solve the diagnostic challenge, next generation sequencing (NGS) was performed to distinguish between the disorders possibly present in the patient. Read More

Hepatobiliary Pancreat Dis Int 2019 Apr 5. Epub 2019 Apr 5.

Department of Hepatopancreatobiliary Surgery, Yin Zhou People's Hospital, Ningbo 315040, China. Electronic address:

J Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

Background And Aims: The clinical efficacy of ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) remains subject to debate as definitive randomized controlled trials are lacking. We aimed to determine whether UDCA prolongs transplantation (LT) free survival in PBC.

Methods: This international cohort study included patients from the Global PBC Study Group database, originating from 8 countries in Europe and North America. Read More

J Hepatobiliary Pancreat Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatric Surgery, King's College Hospital, London, United Kingdom.

Biliary atresia (BA) is a rare cholangiopathy of largely unknown etiology and unpredictable outcome. There has been an increasing number of BA-related publications, which may challenge researchers to determine their actual scientific value. This study aimed to evaluate the global research activity and developments relating to BA using a combination of scientometric methodologies and visualization tools. Read More

Gastrointest Endosc 2019 Apr 9. Epub 2019 Apr 9.

Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA. Electronic address:

Each year choledocholithiasis results in biliary obstruction, cholangitis, and pancreatitis in a significant number of patients. The primary treatment, ERCP, is minimally invasive but associated with adverse events in 6% to 15%. This American Society for Gastrointestinal Endoscopy (ASGE) Standard of Practice (SOP) Guideline provides evidence-based recommendations for the endoscopic evaluation and treatment of choledocholithiasis. Read More

J Surg Case Rep 2019 Apr 6;2019(4):rjz063. Epub 2019 Apr 6.

Department of General and Digestive Surgery, Cruces University Hospital, Plaza Cruces s/n, 48903, Barakaldo, Vizcaya, Spain.

Background: Hepatic artery avulsion following politrauma is an extremely rare condition with a very high mortality rate. Management is based on damage control surgery given the precarious situation of these patients. Ligating the artery is one option under such circumstances, despite potential consequences including ischemic cholangiopathy (IC). Read More

J Autoimmun 2019 Apr 8. Epub 2019 Apr 8.

Gastroenterology & Hepatology Department Hamad Medical Corporation, Qatar; Weill Cornell Medical College, Qatar Br, Qatar. Electronic address:

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease, diagnosed by the presence of anti-mitochondrial antibodies (AMA) or highly PBC-specific anti-nuclear antibodies, in the appropriate context of cholestatic liver biochemistry. We present a case with histological features of destructive granulomatous lymphocytic cholangitis affecting interlobular and septal bile ducts suggestive of PBC, with strong positive AMA, Anti-M2 and anti-nuclear dot, but with persistently normal alkaline phosphatase (ALP). On the contrary to previous reports suggesting that those individuals in whom ALP remains persistently below 1. Read More

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):296-304

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences.

Gut 2019 Apr 10. Epub 2019 Apr 10.

Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Objective: Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign and malignant bile duct strictures remains a diagnostic conundrum. Recent developments in next-generation sequencing (NGS) have opened new opportunities for early detection and management of cancers but, to date, have not been rigorously applied to biliary specimens.

Design: We prospectively evaluated a 28-gene NGS panel (BiliSeq) using endoscopic retrograde cholangiopancreatography-obtained biliary specimens from patients with bile duct strictures. Read More

Hepatol Res 2019 Apr 10. Epub 2019 Apr 10.

School of Medicine, Teikyo University, Tokyo, Japan.

The etiology of autoimmune liver diseases, such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), still remains largely unknown and no therapeutic agents that are able to "cure" the disease have been developed. While corticosteroids for AIH and ursodeoxycholic acid (UDCA) for PBC have been shown to significantly improve liver transplantation (LT)-free survival and are recommended as first-line drugs, treatment strategies for patients who exhibit incomplete response to these drugs have not yet been fully established. No drug is significantly associated with long LT-free survival in PSC patients. Read More

World J Clin Cases 2019 Mar;7(6):759-764

Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola 47014, Italy.

Background: species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from , whereas cases in the west are rare.

Case Summary: We report the case of a 64-year-old woman with advanced pancreatic cancer and jaundice who manifested fever, abdominal pain, severe thrombocytopenia, anemia and kidney failure following the insertion of a percutaneous transhepatic biliary drainage. Read More

Dig Endosc 2019 Apr 9. Epub 2019 Apr 9.

Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan.

Endoscopic dilation for severe benign biliary stricture using mechanical dilation devices is occasionally ineffective. Hence, diathermic dilation has recently been gaining attention as a salvage procedure. We evaluated the short- and long-term outcomes of diathermic dilation for severe benign biliary stricture that could not be dilated using the conventional mechanical dilation. Read More

Clin J Gastroenterol 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology, Tottori Prefectural Central Hospital, Tottori, Japan.

Intraductal papillary mucinous neoplasms (IPMNs) occasionally form a fistula to adjacent organs, resulting in obstructive jaundice and cholangitis due to mucus obstruction. Although some procedures such as endoscopic nasobiliary drainage are attempted, they often do not work adequately because of high mucus viscosity. Herein, we report the case of an 87-year-old man with obstructive cholangitis treated by endoscopic septotomy and mucus suction with direct peroral cholangioscopy using conventional endoscopy. Read More

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

Department of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Outcomes of proximal parenchymal pancreatectomy (PPP) as compared to pancreatoduodenectomy (PD) have not been reported. The aim of this study was to describe the short- and long-term outcomes of patients with low-grade pancreatic head lesions who underwent PPP or PD.

Methods: Patients who underwent PPP or PD for low-grade lesions between 2009 and 2017 were included. Read More

Comp Immunol Microbiol Infect Dis 2019 Apr 3;63:31-36. Epub 2019 Jan 3.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, PR China. Electronic address:

Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease of unknown cause. In the study, we found that duck circovirus (DuCV) induces PSC in natural and reproductive cases. PSC in DuCV naturally infected ducks was investigated by PCR and histopathology. Read More

Aliment Pharmacol Ther 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy.

Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis.

Material And Methods: We used population-based medical registries for a cohort study of patients with liver cirrhosis diagnosed January 2001 to December 2010, in the Scania region of Sweden. Read More

Anticancer Res 2019 Apr;39(4):2155-2161

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/aim: The impact of adjuvant chemotherapy (AC) for extrahepatic cholangiocarcinoma (ECC) remains unclear. This study evaluated the efficacy and limitations of AC.

Patients And Methods: Between 2006 and 2016, 106 patients with stage II-IV ECC who underwent curative resection with biliary tract reconstruction were retrospectively analyzed. Read More

Cir Cir 2019 ;86(1):49-55

Medical Management Office. Hospital General Naval de Alta Especialidad, Secretaría de Marina/Armada de México, Mexico City. Mexico.

Primary sclerosing cholangitis (PSC) is a rare idiopathic condition with immunopathogenic mechanisms where there is chronic progressive destruction of the biliary tree. Secondary sclerosing cholangitis (SSC) is clinically comparable to PSC, but is caused by specific processes which directly damage the biliary tree; examples include recurrent pancreatitis, bile duct malignancy, congenital bile duct abnormalities. A new cause of SSC has been described during or following significant critical illness associated with severe respiratory insufficiency, vasopressor requirement, shock and sepsis. Read More

Gastroenterol Hepatol Bed Bench 2019 ;12(1):76-82

Clinical Investigation Laboratory, ASST Crema, Largo Ugo Dossena- Crema, Cremona, Italy.

Primary biliary cholangitis, previously known as primary biliary cirrhosis (PBC), is the most common autoimmune diseases of the liver (ALD). Patients with PBC may present with typical biliary pattern symptoms. Also the presence of anti-mitochondrial autoantibodies (AMAs) is the laboratory hallmark of PBC, which molecular target antigens are members of 2-oxoacid dehydrogenase complex of enzymes. Read More