13,141 results match your criteria Cholangiocarcinoma


Is hepatectomy safe following Yttrium-90 therapy? A multi-institutional international experience.

HPB (Oxford) 2019 Apr 17. Epub 2019 Apr 17.

University of Wisconsin, United States.

Background: Single institution reports demonstrate variable safety profiles when liver-directed therapy with Yttrium-90 (Y-90) is followed by hepatectomy. We hypothesized that in well-selected patients, hepatectomy after Y90 is feasible and safe.

Methods: Nine institutions contributed data for patients undergoing Y90 followed by hepatectomy (2008-2017). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.366DOI Listing

A novel online prognostic tool to predict long-term survival after liver resection for intrahepatic cholangiocarcinoma: The "metro-ticket" paradigm.

J Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio.

Background: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm.

Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Read More

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http://dx.doi.org/10.1002/jso.25480DOI Listing

Long non-coding RNA LOXL1-AS1 acts as a ceRNA for miR-324-3p to contribute to cholangiocarcinoma progression via modulation of ATP-binding cassette transporter A1.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, 161000, China. Electronic address:

Accumulating evidence has appreciated long non-coding RNAs (lncRNAs) as novel prognostic markers and therapeutic targets in malignant carcinomas. Here, we aim to investigate the value of a novel cancer-related lncRNA, LOXL1-AS1, in cholangiocarcinoma (CCA). LOXL1-AS1 was found overexpressed in CCA tissues screened by high-throughput sequencing technology. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.089DOI Listing

[Corrigendum] Metformin facilitates BG45‑induced apoptosis via an anti‑Warburg effect in cholangiocarcinoma cells.

Oncol Rep 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.

Following the publication of the article, the authors have realized that Fig. 1A contained an error (essentially, the scale bars were drawn incorrectly). The corrected version of Fig. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7111
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http://dx.doi.org/10.3892/or.2019.7111DOI Listing
April 2019
1 Read

Could Hepatitis B Vaccine Act as An Adjuvant to Lower Risk and Relapses of Cancer?

Clin Exp Pharmacol Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Acibadem University, İstanbul, Turkey.

In this review article, we hypothesize that Hepatitis B Virus Vaccine (HBV-V) and certain antigens of Hepatitis B Virus (HBV)-could act as anticancer immunoadjuvants in addition to their role of preventing HBV-associated liver cancer. Evidence suggests that in animal breast cancer and melanoma models, combining hepatitis B-surface antigen (HBsAg) with other cancer antigens resulted in enhanced antitumor activity. HBsAg shares antigenic mimicry with healthy and malignant cells including squamous epithelia, thymic epithelia, bladder- and colon cancer cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13096DOI Listing
April 2019
1 Read

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona.

Importance: Administration of gemcitabine-cisplatin, the current standard therapy for advanced biliary tract cancers, results in median progression-free survival and overall survival of 8.0 and 11.7 months, respectively. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.0270DOI Listing
April 2019
1 Read

IgG4 Sclerosing Cholangitis - an Inflammation Imitating Tumour of the Pancreas and Biliary Tract.

Klin Onkol 2019 ;32(2):143-151

Background: Immunoglobulin (Ig) G4 associated sclerosing cholangitis is a rare inflammatory disease of the biliary tract. Although it is a very progressive condition, it responds to steroid therapy. IgG4 associated sclerosing cholangitis can mimic pancreatic carcinoma, cholangiocarcinoma, and primary sclerosing cholangitis; therefore, it is very important to obtain a differential diagnosis. Read More

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https://www.linkos.cz/english-summary/klinicka-onkologie-jou
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http://dx.doi.org/10.14735/amko2019143DOI Listing
January 2019
2 Reads

Combination of endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography-guided biliary drainage in malignant hilar biliary obstruction.

Dig Endosc 2019 Apr;31 Suppl 1:50-54

Gastrointestinal Endoscopy Excellence Center and Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Adequate biliary drainage (BD), defined as more than 50% of liver volume drained, is an ideal BD method in patients with advanced and unresectable malignant hilar biliary obstruction (MHBO). Endoscopic retrograde cholangiopancreatography (ERCP) with multi-segmental BD is technically challenging. ERCP with percutaneous biliary drainage (PTBD) or PTBD alone has cumbersome maintenance of PTBD line and external bag. Read More

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http://dx.doi.org/10.1111/den.13371DOI Listing
April 2019
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SIRT3 elicited an anti-Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, China.

Cholangiocarcinoma (CCA) is an extremely invasive malignancy with late diagnosis and unfavorable prognosis. Surgery and chemotherapy are still not effective in improving outcomes in CCA patients. It is crucial to explore a novel therapeutic target for treating CCA. Read More

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http://dx.doi.org/10.1002/cam4.2089DOI Listing
April 2019
1 Read

UHRF1 is regulated by miR-124-3p and promotes cell proliferation in intrahepatic cholangiocarcinoma.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai, China.

Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is abnormally overexpressed in multiple cancers and closely correlated with tumor-promoting effects, such as high proliferation. However, how UHRF1 functions in intrahepatic cholangiocarcinoma (ICC) has not yet been determined. Herein, we found that UHRF1 is overexpressed in ICC tissues. Read More

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http://dx.doi.org/10.1002/jcp.28586DOI Listing
April 2019
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Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.

Oncol Lett 2019 May 12;17(5):4514-4520. Epub 2019 Mar 12.

Department of General Surgery, Taihe Hospital Affiliated with Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.

Metadherin (MTDH) is a protein that is also named astrocyte elevated gene-1, and is highly expressed in a number of different tumor tissues. Although the expression of MTDH is associated with tumor invasion and recurrence, the expression of this protein in perihilar cholangiocarcinoma (PCCA) and its clinical use have not yet been investigated. In the present study, the expression of MTDH in patients with PCCA was investigated in order to determine its clinicopathological use. Read More

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http://dx.doi.org/10.3892/ol.2019.10141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447862PMC
May 2019
1 Read

CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling.

Genome Med 2019 Apr 16;11(1):21. Epub 2019 Apr 16.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, 01605, USA.

CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in. Here we developed CRISPR-based Somatic Oncogene kNock-In for Cancer Modeling (CRISPR-SONIC), a method for rapid in vivo cancer modeling using homology-independent repair to integrate oncogenes at a targeted genomic locus. Read More

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http://dx.doi.org/10.1186/s13073-019-0627-9DOI Listing
April 2019
1 Read
4.942 Impact Factor

Contrast-enhanced imaging in hepatic epithelioid hemangioendothelioma: retrospective study of 10 patients.

Z Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine 1, University of Tuebingen, Tuebingen, Germany.

Purpose:  The purpose of this study was to analyze imaging findings in hepatic epithelioid hemangioendothelioma (HEHE) with a particular focus on contrast-enhanced ultrasound (CEUS).

Materials And Methods:  This retrospective multicenter study included 10 patients with histologically proven HEHE from 5 European centers. All existing ultrasound images/videos were independently analyzed by 2 experienced examiners (DEGUM level III, internal medicine) using a standardized evaluation form. Read More

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http://dx.doi.org/10.1055/a-0886-0081DOI Listing
April 2019
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Validation Study of Tumor Invasive Thickness for Postoperative Prognosis in 110 Patients Who Underwent Pancreatoduodenectomy for Distal Cholangiocarcinoma at a Single Institution.

Am J Surg Pathol 2019 May;43(5):717-723

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine.

The pT classification of the 8th American Joint Committee on Cancer (AJCC) for distal cholangiocarcinoma (DCC) is classified according to depth of invasion (DOI), which is the distance from the basal lamina to the most deeply advanced tumor cells. The Nagoya group proposed a new T classification for DCC based on invasive tumor thickness (ITT), which is the maximal vertical distance of the invasive cancer component (the ITT grade). In this study, we aimed to validate the ITT grade for the next pT classification of DCC in 110 patients. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001244DOI Listing
May 2019
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68Ga-Prostate-Specific Membrane Antigen PET/CT in Cholangiocarcinoma: A Potential Biomarker for Targeted Radioligand Therapy?

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Ga-PSMA is a promising tracer for both staging and detection of biochemical recurrence in prostate cancer. Prostate-specific membrane antigen is also expressed in the endothelium of neovasculature of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of 75-year-old man with metastatic cholangiocarcinoma to liver and lymph nodes progressing on chemotherapy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002563DOI Listing
April 2019
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Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery.

World J Gastrointest Oncol 2019 Jan;11(1):39-47

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Aim: To clarify the prognostic significance of preoperative albumin-to-alkaline phosphatase ratio (AAPR) in cholangiocarcinoma (CCA) subjects receiving surgery.

Methods: In this retrospective study, we included 303 CCA patients receiving surgery without preoperative therapy between 2002 and 2014. Clinicopathological characteristics (including AAPR) were analyzed to determine predictors of post-operative overall survival and recurrence-free survival (RFS). Read More

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http://dx.doi.org/10.4251/wjgo.v11.i1.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451927PMC
January 2019
1 Read

LncRNA FENDRR represses proliferation, migration and invasion through suppression of survivin in cholangiocarcinoma cells.

Cell Cycle 2019 Apr 14:1-9. Epub 2019 Apr 14.

a Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University , Zhengzhou , Henan , China.

This study was to investigate the biological function and underlying mechanisms of FENDRR in cholangiocarcinoma (CCA) cell proliferation, migration and invasion. FENDRR and survivin expression in CCA tissues or cell lines were measured by qRT-PCR. In QBC939 and HuCCTl cells, cell proliferation was detected by CCK-8, cell migration and invasion were using transwell assay. Read More

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http://dx.doi.org/10.1080/15384101.2019.1598726DOI Listing
April 2019
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Characterization of Intraductal Papillary Neoplasm of the Bile Duct with Respect to the Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm.

Gut Liver 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepatobiliary Pancreatic Surgery, Shizuoka Cancer Center, Sunto, Japan.

Intraductal papillary neoplasms of the bile duct (IPNBs) are known to show various pathologic features and biological behaviors. Recently, two categories of IPNBs have been proposed based on their histologic similarities to pancreatic intraductal papillary mucinous neoplasms (IPMNs): type 1 IPNBs, which share many features with IPMNs; and type 2 IPNBs, which are variably different from IPMNs. The four IPNB subtypes were re-evaluated with respect to these two categories. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18476DOI Listing
April 2019
4 Reads

Double-balloon enteroscopy-facilitated cyanoacrylate-injection endotherapy of small-bowel varices: an international experience from 2 European tertiary centers (with videos).

Gastrointest Endosc 2019 Apr 10. Epub 2019 Apr 10.

Royal Free Unit for Endoscopy, The Royal Free Hospital and University College London (UCL) Institute for Liver and Digestive Health, Hampstead, London, United Kingdom.

Background And Aims: Small-bowel varices (SBV) are an uncommon consequence of portal hypertension. Radiological intervention (RI) is usually considered for first-line management. When RI is not possible, management options become very limited. Read More

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http://dx.doi.org/10.1016/j.gie.2019.03.1171DOI Listing
April 2019
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CYP2C9, CYP2C19, CYP2D6 and CYP3A5 polymorphisms in South-East and East Asian populations: A systematic review.

J Clin Pharm Ther 2019 Apr 13. Epub 2019 Apr 13.

Chulabhorn International College of Medicine, Rangsit Center, Thammasat University, Klong Luang, Pathum Thani, Thailand.

What Is Known And Objective: Genetic polymorphism is one of the most important factors responsible for interindividual and interethnic variability in drug response. Studies in major populations, ie, Caucasians, Asians, and Africans, have provided evidence of differences in the genotype frequencies of major drug-metabolizing enzyme cytochrome P450 (CYP). This study aimed to review systematically, all relevant articles related to the genetic polymorphisms in CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in South-East and East Asian (SEEA) populations. Read More

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http://dx.doi.org/10.1111/jcpt.12835DOI Listing
April 2019
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Radiological findings and surgical outcomes of pulmonary metastases originating from biliary tract carcinoma.

Gen Thorac Cardiovasc Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: Metastasis to the lungs arising from biliary tract carcinoma (BTC) is extremely rare, and the patient characteristics and prognosis are not well known. We aimed to identify the imaging findings of pulmonary metastases originating from BTC and the eligible indications for surgical treatment.

Methods: Fifteen patients who underwent pulmonary resection for metastases originating from BTC were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s11748-019-01122-6DOI Listing
April 2019
1 Read

Defining enhanced recovery after resection of peri-hilar cholangiocarcinoma.

Eur J Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Northwest Hepatobiliary Centre, University Hospital Aintree, Liverpool, UK.

Introduction: Enhanced recovery after surgery (ERAS) for peri-hilar cholangiocarcinoma (pCCA) has not been described in the literature. This study examined patients undergoing pCCA resection within a standard post hepatectomy ERAS pathway to define achievable targets suitable for these patients.

Methods: Patients undergoing pCCA resection at University Hospital Aintree (January 2009-October 2017) were identified. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.033DOI Listing
March 2019
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Establishment and Characterization of a New Intrahepatic Cholangiocarcinoma Cell Line Resistant to Gemcitabine.

Cancers (Basel) 2019 Apr 11;11(4). Epub 2019 Apr 11.

Division of Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

Intrahepatic cholangiocarcinoma (ICC) is one of the most lethal liver cancers. Late diagnosis and chemotherapy resistance contribute to the scarce outfit and poor survival. Resistance mechanisms are still poorly understood. Read More

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http://dx.doi.org/10.3390/cancers11040519DOI Listing
April 2019
1 Read

Predicting peritumoral Glisson's sheath invasion of intrahepatic cholangiocarcinoma with preoperative CT imaging.

Quant Imaging Med Surg 2019 Feb;9(2):219-229

Department of Radiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.

Background: To investigate the differences of clinicopathological characteristics and computed tomography (CT) features between intrahepatic cholangiocarcinomas (ICC) with and without peritumoral Glisson's sheath invasion (PGSI), and to construct a nomogram to predict PGSI of ICCs preoperatively.

Methods: The clinicopathological characteristics and CT features of 84 ICCs were retrospectively analyzed and compared between ICCs with (30/84, 35.7%) and without PGSI (54/84, 64. Read More

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http://dx.doi.org/10.21037/qims.2018.12.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414767PMC
February 2019
1 Read

Is exposure to tobacco associated with extrahepatic cholangiocarcinoma epidemics? A retrospective proportional mortality study in China.

BMC Cancer 2019 Apr 11;19(1):348. Epub 2019 Apr 11.

Cancer Institute & Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China.

Background: Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this study aimed to explore this relationship.

Methods: We included 55,806 participants aged 30 years or older from the National Mortality and Smoking Survey of China. Read More

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http://dx.doi.org/10.1186/s12885-019-5484-9DOI Listing
April 2019
2 Reads

Causes of hOCT1-dependent cholangiocarcinoma resistance to sorafenib and sensitization by tumor-selective gene therapy.

Hepatology 2019 Apr 10. Epub 2019 Apr 10.

Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain.

Although the multi-tyrosine kinase inhibitor, sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug. Among other mechanisms of chemoresistance impaired uptake via hOCT1 (gene SLC22A1) has been suggested. Here we have investigated the events accounting for this phenotypic characteristic and have evaluated the interest of selective gene therapy strategies to overcome this limitation. Read More

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http://dx.doi.org/10.1002/hep.30656DOI Listing
April 2019
1 Read

Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures.

Gut 2019 Apr 10. Epub 2019 Apr 10.

Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Objective: Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign and malignant bile duct strictures remains a diagnostic conundrum. Recent developments in next-generation sequencing (NGS) have opened new opportunities for early detection and management of cancers but, to date, have not been rigorously applied to biliary specimens.

Design: We prospectively evaluated a 28-gene NGS panel (BiliSeq) using endoscopic retrograde cholangiopancreatography-obtained biliary specimens from patients with bile duct strictures. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317817DOI Listing
April 2019
1 Read

Successful resection of intrahepatic cholangiocarcinoma with idiopathic thrombocytopenic purpura using thrombopoietin receptor agonist: a case report.

Surg Case Rep 2019 Apr 10;5(1):56. Epub 2019 Apr 10.

Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Patients with idiopathic thrombocytopenic purpura (ITP) have low platelet counts and an increased risk of complications. Therefore, these patients generally require high-dose immunoglobulin therapy and platelet transfusion. However, thrombopoietin receptor agonists (TPO-RAs) have recently become available for use in the preoperative treatment strategy for intractable ITP. Read More

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http://dx.doi.org/10.1186/s40792-019-0619-4DOI Listing
April 2019
1 Read

Editorial: Parasites and Cancer.

Front Med (Lausanne) 2019 22;6:55. Epub 2019 Mar 22.

Institute of Tropical Medicine and International Health, Charité University Medicine, Berlin, Germany.

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http://dx.doi.org/10.3389/fmed.2019.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438845PMC
March 2019
1 Read

LncRNA LINC01061 sponges miR-612 to regulate the oncogenic role of SEMA4D in cholangiocarcinoma.

Biochem Biophys Res Commun 2019 Apr 6. Epub 2019 Apr 6.

The First Department of General Surgery, Affiliated Hospital of Chengde Medical College, Chengde, Hebei, 067000, PR China.

Cholangiocarcinoma (CCA) is the most usual malignancy of biliary tract, possessing a relatively low overall survival rate due to limited treatment options. Recently, long non-coding RNAs (lncRNAs) have been testified to have marked regulatory impacts on human cancers. The purpose of this paper is to explore the potent regulation mechanism of LINC01061 involved in CCA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193051
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http://dx.doi.org/10.1016/j.bbrc.2019.03.125DOI Listing
April 2019
7 Reads

Combined Treatment of Nonresectable Cholangiocarcinoma Complicated by Obstructive Jaundice.

Photodiagnosis Photodyn Ther 2019 Apr 6. Epub 2019 Apr 6.

Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str., 38, Moscow, 119991, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoye sh., 31, Moscow, 115409, Russia. Electronic address:

Background: The five-year survival rate for successful surgical treatment of cholangiocellular cancer is only 20-40%, and in the case of an unresectable tumor, the life expectancy does not exceed 6 months. These terms decrease with the presence of jaundice due to the spread of the tumor process along the bile ducts, leading to their obstruction. The outcomes of patients with nonresectable bile duct carcinoma complicated by obstructive jaundice have been shown. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.006DOI Listing
April 2019
3 Reads

Relevance of Preoperative Hyperbilirubinemia in Patients Undergoing Hepatobiliary Resection for Hilar Cholangiocarcinoma.

J Clin Med 2019 Apr 5;8(4). Epub 2019 Apr 5.

Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 1A Banacha Street, 02-097 Warsaw, Poland.

Preoperative hyperbilirubinemia is known to increase the risk of mortality and morbidity in patients undergoing resection for hilar cholangiocarcinoma. The aim of this study was to characterize the associations between the preoperative bilirubin concentration and the risk of postoperative mortality and severe complications to guide decision-making regarding preoperative biliary drainage. Eighty-one patients undergoing liver and bile duct resection for hilar cholangiocarcinoma between 2005 and 2015 were analyzed retrospectively. Read More

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http://dx.doi.org/10.3390/jcm8040458DOI Listing
April 2019
1 Read

Incidence of Cholangiocarcinoma in the USA from 2001 to 2015: A US Cancer Statistics Analysis of 50 States.

Cureus 2019 Jan 25;11(1):e3962. Epub 2019 Jan 25.

Internal Medicine, Temple University, Philadelphia, USA.

Introduction Cholangiocarcinoma is an aggressive and rare cancer of the bile duct with a very poor prognosis. It accounts for approximately three percent of gastrointestinal cancers but nearly 20 percent of deaths are from hepatobiliary cancers. Cholangiocarcinoma is also a clinically silent disease that presents at advanced stages. Read More

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http://dx.doi.org/10.7759/cureus.3962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436669PMC
January 2019
1 Read

Prognostic relevance of preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 in a multicenter subset analysis of 179 patients with distal cholangiocarcinoma.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

Dept. for Visceral, Thoracic and Vascular Surgery at the University Hospital, Technical University Dresden, Dresden, Germany. Electronic address:

Background: Distal cholangiocarcinoma (DCC) is a rare malignancy and validated prognostic markers remain scarce. We aimed to evaluate the role of serum CA19-9 as a potential biomarker in DCC.

Methods: Patients operated for DCC at 6 high-volume surgical centers from 1994 to 2015 were identified from prospectively maintained databases. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.363DOI Listing
April 2019
1 Read

FAPI-PET/CT: Mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer.

J Nucl Med 2019 Apr 6. Epub 2019 Apr 6.

University Hospital Heidelberg, Germany.

The recent development of quinoline based positron-emission-tomography (PET)-tracers that act as fibroblast-activation-protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is overexpressed by cancer associated fibroblasts (CAFs) of several tumor entities. Here we quantify the tumor-uptake in FAPI-PET/CT of various primary and metastatic tumors to identify the most promising indications for future application. Read More

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http://dx.doi.org/10.2967/jnumed.119.227967DOI Listing
April 2019
1 Read

Hepatitis C Virus Infection and Cholangiocarcinoma: An Insight into Epidemiologic Evidences and Hypothetical Mechanisms of Oncogenesis.

Am J Pathol 2019 Apr 4. Epub 2019 Apr 4.

Baylor Scott & White Digestive Disease Research Center, Temple, Texas; Division of Research, Central Texas Veterans Health Care System, Temple, Texas. Electronic address:

Hepatitis C virus (HCV) infection is a global public health problem because it is a main cause of liver cirrhosis and hepatocellular carcinoma. This human oncogenic virus is also associated with the development of non-Hodgkin lymphoma and cholangiocarcinoma (CCA). The association between HCV infection and CCA has been examined in a number of epidemiologic studies. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.018DOI Listing
April 2019
5 Reads

Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis.

BMC Cancer 2019 Apr 5;19(1):318. Epub 2019 Apr 5.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical and histopathological similarity. This is an important problem, because the distinction has important implications for the treatment of these malignancies. However, there are no biomarkers for the differential diagnosis of PHC and DCC. Read More

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http://dx.doi.org/10.1186/s12885-019-5548-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451218PMC
April 2019
4 Reads

The Efficacy and Limitations of Postoperative Adjuvant Chemotherapy in Patients With Extrahepatic Cholangiocarcinoma.

Anticancer Res 2019 Apr;39(4):2155-2161

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/aim: The impact of adjuvant chemotherapy (AC) for extrahepatic cholangiocarcinoma (ECC) remains unclear. This study evaluated the efficacy and limitations of AC.

Patients And Methods: Between 2006 and 2016, 106 patients with stage II-IV ECC who underwent curative resection with biliary tract reconstruction were retrospectively analyzed. Read More

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http://dx.doi.org/10.21873/anticanres.13329DOI Listing
April 2019
1 Read

A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular-Cholangiocarcinoma.

Anticancer Res 2019 Apr;39(4):2139-2144

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. Read More

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http://dx.doi.org/10.21873/anticanres.13327DOI Listing
April 2019
2 Reads

Comparison of the Clinicopathological Features in Small Bile Duct and Bile Ductular Type Intrahepatic Cholangiocarcinoma.

Anticancer Res 2019 Apr;39(4):2121-2127

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Background: The classification of intrahepatic cholangiocarcinomas (ICCs) has been reported in several studies, however, it remains controversial.

Materials And Methods: Between January 2003 and December 2015, 94 patients underwent hepatectomy for ICC. The ICCs of 63 of these patients were classified as predominantly small bile duct type or bile ductular type ICC and were included in this analysis. Read More

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http://dx.doi.org/10.21873/anticanres.13325DOI Listing
April 2019
2 Reads

α7-Nicotinic Acetylcholine Receptor Promotes Cholangiocarcinoma Progression and Epithelial-Mesenchymal Transition Process.

Dig Dis Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266003, Shandong, China.

Background: Cholangiocarcinoma is one of the most deadly malignant tumors characterized by a tendency of local invasiveness and metastasis at the early phase, high recurrence rate, and difficulty in treatment. Alpha7-nicotinic acetylcholine receptor (α7-nAChR) is highly expressed in a variety of tumors, including cholangiocarcinoma, and may promote tumor progression, but the mechanisms are largely unknown.

Aims: Our study is the first to expound upon the role that α7-nAChR plays in cholangiocarcinoma. Read More

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http://dx.doi.org/10.1007/s10620-019-05609-3DOI Listing
April 2019
1 Read

Short- and Long-Term Outcomes of Liver Resection for Intrahepatic Cholangiocarcinoma Associated with the Metabolic Syndrome.

World J Surg 2019 Apr 4. Epub 2019 Apr 4.

Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Background: While the metabolic syndrome (MS) is being recognized as an important risk factor for intrahepatic cholangiocarcinoma (ICC), the outcomes of liver resection in this context remain poorly described. This study aims to report the short- and long-term results of hepatectomy for patients with MS as risk factor for the development of ICC (MS+).

Methods: All patients undergoing hepatectomy for ICC between 2000 and 2016 at a single center were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00268-019-04996-yDOI Listing
April 2019
4 Reads

Targeting sphingosine kinase 2 suppresses cell growth and synergizes with BCL2/BCL-XL inhibitors through NOXA-mediated MCL1 degradation in cholangiocarcinoma.

Am J Cancer Res 2019 1;9(3):546-561. Epub 2019 Mar 1.

Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University Nanjing 210008, Jiangsu, China.

Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-survival sphingosine-1-phosphate. We have previously shown that ABC294640, a first-in-class SPHK2 inhibitor, inhibits growth of cholangiocarcinoma cells. In a Phase I study of ABC294640 in tumors, the best response was achieved in a cholangiocarcinoma patient. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448062PMC
March 2019
5 Reads
3.968 Impact Factor

EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress.

J Oncol 2019 4;2019:8701824. Epub 2019 Mar 4.

Department of Internal Medicine 3, Center of Integrated Oncology (CIO) Cologne-Bonn, University Hospital of Bonn, Germany.

Therapeutic options for advanced stage cholangiocellular carcinoma (CCC) are very limited as of today and patients carry an exceptionally poor overall prognosis. In recent years, increasing evidence has been accumulated to suggest that malignant cells widely show increased intrinsic ROS levels and exhibit altered redox profiles as compared to normal counterparts, opening up potential avenues for therapeutic intervention. This study provides preclinical experimental evidence of therapeutic activity of the curcumin analog EF24 in cholangiocarcinoma models. Read More

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http://dx.doi.org/10.1155/2019/8701824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425401PMC
March 2019
2 Reads

Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation.

Gastroenterol Hepatol 2019 Apr 1. Epub 2019 Apr 1.

Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, IIS Aragón, Ciberehd, Zaragoza, España.

The association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern) and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02105705193005
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http://dx.doi.org/10.1016/j.gastrohep.2019.02.004DOI Listing
April 2019
3 Reads

Elevation of circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma.

Aging (Albany NY) 2019 Apr;11(7):1907-1917

Department of Hepatopancreatobiliary Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.

Cholangiocarcinoma (CCA) is a highly malignant carcinoma with high mortality rate worldwide. Emerging evidence indicates that aberrantly expressed circular RNAs (circRNAs) functions crucial roles in tumor progression. In this work, we focused on a novel circRNA, circ_0005230, in carcinogenesis and development of CCA. Read More

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http://dx.doi.org/10.18632/aging.101872DOI Listing
April 2019
3 Reads

A Study on Radial Margin Status in Resected Perihilar Cholangiocarcinoma.

Ann Surg 2019 Apr 2. Epub 2019 Apr 2.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

MINI: This study investigated radial margin status in 478 patients who underwent hepatectomy for perihilar cholangiocarcinoma. Positive radial margin status was the most common cause for R1 resection and had similarly negative effects on postoperative survival similar as positive ductal margin status.

Objective: To investigate radial margin (RM) status in resected perihilar cholangiocarcinoma (PHCC) and to evaluate the incidence of positive RM and its effect on survival. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003305DOI Listing
April 2019
3 Reads

Programmed Death-1 Inhibitor for Occupational Intrahepatic Cholangiocarcinoma Caused by Chlorinated Organic Solvents.

J Hepatobiliary Pancreat Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

In 2014, the International Agency for Research on Cancer classified 1,2-dichloropropane (DCP) as class 1 (carcinogenic for humans) and dichloromethane (DCM) as group 2A (possibly carcinogenic to humans) because of a cholangiocarcinoma outbreak among young adult workers; they were exposed to high concentrations of DCP and/or DCM for a long-term in an offset color proof-printing department at a printing company in Osaka, Japan. The Ministry of Health, Labor, and Welfare of Japan classified this type of cholangiocarcinoma as "occupational cholangiocarcinoma." Our previous study showed that other than the main tumor, chronic bile duct injury and precancerous lesions were observed at various sites of the large bile duct . Read More

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http://dx.doi.org/10.1002/jhbp.623DOI Listing
April 2019
2 Reads

Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine.

PLoS Negl Trop Dis 2019 Apr 3;13(4):e0006843. Epub 2019 Apr 3.

Department of Parasitology and Tropical Medicine and Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Clonorchis sinensis is a group I bio-carcinogen responsible for cholangiocarcinoma (CHCA) in humans. However, the mechanism by which C. sinensis promotes carcinogenesis is unclear. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006843DOI Listing
April 2019
3 Reads