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Hepatology 2021 May 15. Epub 2021 May 15.

Mayo Clinic, United States.

Thank you for your letter and the attention to important risk associations between smoking and immunosuppression with malignancy. As you rightly mention, the limitations of the UNOS database preclude analyzing those factors in our study and others like it. Unfortunately, these types of large databases do not provide information on many possible cofounding factors including smoking status, prior surgical history including a prior colectomy, family history, and specifics regarding a patient's history of malignancy prior to transplant (exceptions including hepatocellular carcinoma and cholangiocarcinoma). Read More

Support Care Cancer 2021 May 14. Epub 2021 May 14.

Department of Radiology, Shengjing Hospital of China Medical University, Huaxiang Road 39, Shenyang City, 110004, Liaoning Province, China.

Purpose: The purpose of this study is to investigate the influencing factors that may impact the clinical success, jaundice-free time, and overall survival in patients of malignant hilar biliary obstruction (MHBO) treated with a self-expanding metallic stent (SEMS).

Materials And Methods: Patients diagnosed with MHBO and treated with SEMS through percutaneous access from 1 Jul. 2013 to 1 Jul. Read More

Parasitol Int 2021 May 10:102382. Epub 2021 May 10.

Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Thailand.

Liver fluke infection through the consumption of raw or undercooked freshwater fish is a major public health problem in the Mekong Region. Despite the extensive efforts of liver fluke health campaigns, Northeast Thailand still reports high human infection prevalence as consumption of raw fish dishes has diminished but not ceased. This study examines the roles of social-cultural factors, particularly the influences of masculinity and misinformation, on liver fluke infection risk. Read More

J Int Med Res 2021 May;49(5):3000605211008336

Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.

Objective: To compare the outcomes of the transhepatic hilar approach and conventional approach for surgical treatment of Bismuth types III and IV perihilar cholangiocarcinoma.

Methods: We retrospectively reviewed the medical records of 82 patients who underwent surgical resection of Bismuth types III and IV perihilar cholangiocarcinoma from 2008 to 2016. The transhepatic hilar approach and conventional approach was used in 36 (43. Read More

Mol Clin Oncol 2021 Jun 26;14(6):126. Epub 2021 Apr 26.

[This corrects the article DOI: 10.3892/mco.2021. Read More

J Cancer 2021 30;12(11):3114-3125. Epub 2021 Mar 30.

Medical Centre for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China.

Elderly patients with Intrahepatic Cholangiocarcinoma (ICC) are frequently under-represented in clinical trials, which leads to the unclear management of ICC in elderly patients. This study aimed to describe treatment patterns and establish a reliable nomogram in elderly ICC patients. Based on the Surveillance, Epidemiology, and End Results (SEER) database, we conducted a retrospective analysis of 1651 elderly patients (≥65 years) diagnosed with ICC between 2004 and 2016. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):557-559

Dept. of Surgery, Takaoka City Hospital.

An 82‒year‒old female presented to our hospital with abdominal fullness and loss of appetite. Abdominal computed tomography revealed a cholangiocarcinoma(Stage Ⅳ)with liver metastases and multiple lymph node metastases. In addition, we found a left ovarian teratoma(approximately 33 cm in diameter)occupying most of the abdominal cavity. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):543-545

Dept. of Surgery, Chiba Rosai Hospital.

Intrahepatic cholangiocarcinoma(ICC)is the second most common malignant liver tumor after hepatocellular carcinoma (HCC). ICC is usually ischemic; however, it has variable findings and may be difficult to differentiate from HCC. We report about a case of ICC that was difficult to distinguish from HCC treated by radiofrequency ablation(RFA). Read More

HPB (Oxford) 2021 Apr 28. Epub 2021 Apr 28.

Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA.

Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Read More

Expert Rev Gastroenterol Hepatol 2021 May 10:1-14. Epub 2021 May 10.

Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.

:Although advances in understanding the molecular basis of cholangiocarcinoma (CCA) have been made, surgery is the only curative therapy option and the overall prognosis of patients suffering from the disease remains poor. Therefore, estimation of prognosis based on known and novel biomarkers is essential for therapy guidance of CCA in both, curative and palliative settings.:An extensive literature search on biomarkers for CCA with special emphasis on prognosis was performed. Read More

J Palliat Med 2021 May 10. Epub 2021 May 10.

Department of Internal Medicine, Walter Cantidio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Near-death awareness (NDA) refers to visions and dreams commonly experienced by terminally ill individuals within months to hours before death. A case report of a 68-year-old Jamaican male diagnosed with advanced cholangiocarcinoma, who experienced visions of his deceased mother during hospitalization. This article discusses how to differentiate NDA from delirium, core components for determining decisional capacity, and how clinicians can use a cultural guide to optimize patient-centered care. Read More

J Laparoendosc Adv Surg Tech A 2021 May 7. Epub 2021 May 7.

Division of Hepato-biliary-pancreatic Surgery, Department of Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain.

Biliary tree cysts (BTCs) represent an either localized or multifocal abnormal dilatation of the biliary tree, which entails an increased risk of acute cholangitis and cholangiocarcinoma (2.5%-16%). Its incidence in Western countries is ∼1/100. Read More

Front Oncol 2021 22;11:680500. Epub 2021 Apr 22.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, China.

[This corrects the article DOI: 10.3389/fonc.2020. Read More

Front Oncol 2021 21;11:644854. Epub 2021 Apr 21.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Fibroblast growth factor receptor 2 (FGFR2) is frequently altered in tumors and one of the top therapeutic targets in cholangiocarcinoma (CHOL) with fusions. Although there have been several studies on individual tumors, a comprehensive analysis of genetic aberrations and their simultaneous clinical implications across different tumors have not been reported. In this study, we used the large comprehensive datasets available, covering over 10,000 tumor samples across more than 30 cancer types, to analyze abnormal expression, methylation, alteration (mutations/fusions and amplification/deletion), and their clinical associations. Read More

Case Reports Hepatol 2021 21;2021:6654229. Epub 2021 Apr 21.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine/New-York Presbyterian, New York, New York, USA.

Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literature regarding the nonsurgical management of these patients upon disease recurrence remains limited. Read More

Clin Liver Dis (Hoboken) 2021 Apr 1;17(4):255-260. Epub 2021 May 1.

Department of Pathology Mayo Clinic Florida Jacksonville FL.

Int J Surg Case Rep 2021 Apr 30;82:105936. Epub 2021 Apr 30.

Department of Surgery, Shiga General Hospital, Moriyama, 5-4-30 Moriyama, Moriyama, Shiga 524-8524, Japan. Electronic address:

Introduction And Importance: The most common liver malignancies are hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic tumors. Hepatocellular carcinoma and intrahepatic cholangiocarcinoma may invade the portal vein (PV). An association between diffuse large B-cell lymphoma (DLBCL) and primary biliary cholangitis (PBC) remains unclear. Read More

Clin Cancer Res 2021 May 7. Epub 2021 May 7.

Department of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center

Lymph node metastasis (LNM) drastically reduces survival after resection of intrahepatic cholangiocarcinoma (IHC). Optimal treatment is ill-defined, and it is unclear if tumor mutational profiling can support treatment decisions. Patients with liver-limited IHC with or without LNM treated with resection (N=237), hepatic arterial infusion chemotherapy (HAIC) (N=196), or systemic chemotherapy alone (SYS) (N=140) at our institution between 2000-2018 were included. Read More

World J Surg Oncol 2021 May 7;19(1):142. Epub 2021 May 7.

Department of Surgery, Tokushima University, Tokushima, 770-8503, Japan.

Background: No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell leukemia/lymphoma 2 (Bcl2) and to elucidate the clinicopathological features of each group.

Methods: Fifty-two IHCC patients who underwent hepatic resection were enrolled in this study. Read More