12,916 results match your criteria Cholangiocarcinoma


Enhanced expression of ten-eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P-glycoprotein expression.

Cancer Med 2019 Feb 19. Epub 2019 Feb 19.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Increasing evidence revealed that ten-eleven translocation 1 (TET1) plays an important role in tumorigenesis and chemoresistance, but its functions in gemcitabine resistance in cholangiocarcinoma (CCA) remain unknown. This study aims to investigate the effect of TET1 on gemcitabine resistance in CCA and the possible effect on P-glycoprotein (P-gp) expression encoded by multidrug resistance (MDR) genes. We established two kinds of gemcitabine-resistant CCA cell lines and confirmed its specific features. Read More

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http://dx.doi.org/10.1002/cam4.1983DOI Listing
February 2019

Differentiating IgG4-related sclerosing cholangiopathy from cholangiocarcinoma using CT and MRI: experience from a tertiary referring center.

Abdom Radiol (NY) 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA.

Purpose: To compare the cross-sectional imaging findings of immunoglobulin G4-related sclerosing cholangiopathy (IgG4-SC) and cholangiocarcinoma (CCA).

Methods: Retrospective search of radiology and pathology databases identified 24 patients with IgG4-SC and over 500 patients with CCA from January 2009 to December 2016. Patients with no pre-treatment imaging studies available on PACS, non-contrasted imaging only, presence of mass lesions, metastatic disease or biliary stents were excluded. Read More

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http://link.springer.com/10.1007/s00261-019-01944-1
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http://dx.doi.org/10.1007/s00261-019-01944-1DOI Listing
February 2019
4 Reads

Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies.

World J Gastroenterol 2019 Feb;25(6):659-671

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra- and/or extrahepatic biliary ducts. While its features and disease course can be variable, most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378537PMC
February 2019

Regional therapies for the treatment of primary and metastatic hepatic tumors: A disease-based review of techniques and critical appraisal of current evidence.

Am J Surg 2019 Mar 16;217(3):541-545. Epub 2018 Oct 16.

Spectrum Health General Surgery Residency Program, Grand Rapids, MI, USA; Michigan State University College of Human Medicine, Department of Surgery, Grand Rapids, MI, USA; Spectrum Health Medical Group, Division of Surgical Oncology, Grand Rapids, MI, USA. Electronic address:

The practice of hepatic surgery has become increasingly complex as additional therapeutic options emerge to treat both primary and metastatic tumors of the liver. Liver-directed therapy options include selective internal radiation therapy (SIRT), stereotactic body radiation therapy, chemoembolization, bland embolization, hepatic artery infusion chemotherapy (HAIC), and ablative techniques such as microwave or radiofrequency ablation. Hepatocellular carcinoma has been treated with many of these therapies for palliation of symptoms, definitive treatment, and as a bridge to transplantation. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.10.018DOI Listing

GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma.

Invest New Drugs 2019 Feb 19. Epub 2019 Feb 19.

Genoscience Pharma, 10 Rue d'Iéna, Marseille, France.

Among the acquired modifications in cancer cells, changes in lysosomal phenotype and functions are well described, making lysosomes a potential target for novel therapies. Some weak base lipophilic drugs have a particular affinity towards lysosomes, taking benefits from lysosomal trapping to exert anticancer activity. Here, we have developed a new lysosomotropic small molecule, GNS561, and assessed its activity in multiple in vitro intrahepatic cholangiocarcinoma models (HuCCT1 and RBE cell lines and patient-derived cells) and in a chicken chorioallantoic membrane xenograft model. Read More

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http://dx.doi.org/10.1007/s10637-019-00741-3DOI Listing
February 2019

Piperlongumine-Eluting Gastrointestinal Stent Using Reactive Oxygen Species-Sensitive Nanofiber Mats for Inhibition of Cholangiocarcinoma Cells.

Nanoscale Res Lett 2019 Feb 18;14(1):58. Epub 2019 Feb 18.

School of Medicine, Pusan National University, Yangsan, Gyeongnam, 50612, South Korea.

Background: The aim of this study is to fabricate drug-eluting gastrointestinal (GI) stent using reactive oxygen species (ROS)-sensitive nanofiber mats for treatment of cholangiocarcinoma (CCA) cell. A ROS-producing agent, piperlongumine (PL)-incorporated nanofiber mats were investigated for drug-eluting stent (DES) application.

Methods: Selenocystamine-conjugated methoxy poly(ethylene glycol) (MePEG) was conjugated with poly(L-lactide) (PLA) to produce block copolymer (LEse block copolymer). Read More

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https://nanoscalereslett.springeropen.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s11671-019-2887-0DOI Listing
February 2019
2 Reads

Analysis of intrahepatic sarcomatoid cholangiocarcinoma: Experience from 11 cases within 17 years.

World J Gastroenterol 2019 Feb;25(5):608-621

Department of Internal Medicine, Dong-A University College of Medicine, Busan 49201, South Korea.

Background: Intrahepatic sarcomatoid chonalgiocarcinoma (s-CCC) is an extremely rare disease, accounting for less than 1% of hepatobiliary system malignancies, and its pathophysiology is not well known. On the hypothesis that its clinical, serologic, or radiologic diagnosis are not fully understood and its prognosis is poor, we investigated the distinguishing features of s-CCC compared with those of intrahepatic bile duct adenocarcinoma [cholangiocellular carcinoma (CCC)] in patients from a single center.

Aim: To analyze the clinical, serologic, imaging, and histopathologic characteristics of intrahepatic s-CCC patients diagnosed in a single center. Read More

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http://dx.doi.org/10.3748/wjg.v25.i5.608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371010PMC
February 2019

Programmed death ligand-1, tumor infiltrating lymphocytes and HLA expression in Chinese extrahepatic cholangiocarcinoma patients: Possible immunotherapy implications.

Biosci Trends 2019 Feb 15. Epub 2019 Feb 15.

School of Clinical Medicine, Tsinghua University.

Immunotherapy might be an effective treatment in extrahepatic cholangiocarcinoma (eCCA), a tumor with extremely limited therapeutic options. Our study is to characterize the programmed death ligand-1 (PD-L1) protein expression and cancer microenvironment profiles in surgically resected eCCA samples. PD-L1 positivity was observed on tumor cells (32. Read More

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http://dx.doi.org/10.5582/bst.2019.01003DOI Listing
February 2019

Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
February 2019
1 Read

Inflammatory cells infiltrate and angiogenesis in locally advanced and metastatic cholangiocarcinoma.

Eur J Clin Invest 2019 Feb 14:e13087. Epub 2019 Feb 14.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.

Background: Cholangiocarcinoma (CCA) is the second most common subtype of primary hepatobiliary cancer and one of the most aggressive characterized by an extremely poor prognosis with limited treatment options. Inflammatory cells in tumor microenvironment support tumor growth in term of progression, angiogenesis and metastatic capacity. A link between inflammation and biliary carcinogenesis has been previously observed but the mechanisms involved remain to be determined. Read More

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http://dx.doi.org/10.1111/eci.13087DOI Listing
February 2019

Hedgehog Signaling Modulates Interleukin-33-Dependent Extrahepatic Bile Duct Cell Proliferation in Mice.

Hepatol Commun 2019 Feb 11;3(2):277-292. Epub 2018 Dec 11.

Department of Internal Medicine University of Michigan Ann Arbor MI.

Hedgehog (HH) signaling participates in hepatobiliary repair after injury and is activated in patients with cholangiopathies. Cholangiopathies are associated with bile duct (BD) hyperplasia, including expansion of peribiliary glands, the niche for biliary progenitor cells. The inflammation-associated cytokine interleukin (IL)-33 is also up-regulated in cholangiopathies, including cholangiocarcinoma. Read More

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http://dx.doi.org/10.1002/hep4.1295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357834PMC
February 2019

The interaction between lncRNA SNHG1 and miR-140 in regulating growth and tumorigenesis via TLR4/NF-κB pathway in cholangiocarcinoma.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.

Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. Read More

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http://dx.doi.org/10.3727/096504018X15420741307616DOI Listing
February 2019

Concurrent Pancreatic Metastasis From Lung Adenocarcinoma and Primary Cholangiocarcinoma on FDG PET/CT Imaging.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 67-year-old man with a history of left upper lobe resection of poorly differentiated adenocarcinoma 1 year ago underwent FDG PET/CT for restaging. The images demonstrated a round cystic lesion with peripheral FDG uptake and centrally photopenic region. Additional focus of increased activity was detected in the left lobe of the liver. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002496DOI Listing
February 2019

Cholangiocarcinoma is associated with a raised enhanced liver fibrosis (ELF) score independent of primary sclerosing cholangitis.

Eur J Clin Invest 2019 Feb 14:e13088. Epub 2019 Feb 14.

Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom.

Background: Cholangiocarcinoma (CCA) complicates primary sclerosing cholangitis (PSC) in 10-20% of cases, but current tools for prediction of a CCA diagnosis are inadequate. Recently we demonstrated the utility of the ELF test to stratify prognosis in PSC. We observed that patients with PSC+CCA had significantly higher ELF score than those with PSC alone. Read More

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http://dx.doi.org/10.1111/eci.13088DOI Listing
February 2019
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Significance of Autophagy in Dengue Virus Infection: A Brief Review.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand.

Dengue virus (DENV) causes asymptomatic to severe life-threatening infections and affects millions of people worldwide. Autophagy, a cellular degradative pathway, has both proviral and antiviral functions. Dengue virus triggers the autophagy pathway for the successful replication of its genome. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0761DOI Listing
February 2019

Repeated Treatment with Y-Microspheres in Intrahepatic Cholangiocarcinoma Relapsed After the First Radioembolization.

Cancer Biother Radiopharm 2019 Feb 13. Epub 2019 Feb 13.

1 Department of Nuclear Medicine, Santa Maria Goretti Hospital, Latina, Italy.

Background: The aim of this study was to evaluate the safety and efficacy of repeated administration of Y-microspheres in intrahepatic cholangiocarcinoma (ICC) relapsed after the first radioembolization (RE).

Methods: Nine patients with ICC relapsed after the first Y-RE were enrolled. Six patients presented recurrence in the right hepatic lobe, 3 in the left lobe. Read More

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http://dx.doi.org/10.1089/cbr.2018.2718DOI Listing
February 2019
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[Importance of the lymph node status in patients with hilar cholangiocarcinoma].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0835-2DOI Listing
February 2019

[Perihilar cholangiocarcinoma Bismuth type IV: Resection frequently possible].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0849-9DOI Listing
February 2019

[Importance of repeated liver resection in recurrent intrahepatic cholangiocarcinoma].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0852-1DOI Listing
February 2019

[Unresectable intrahepatic cholangiocarcinoma: 50 % resectability after neoadjuvant therapy].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0875-7DOI Listing
February 2019

Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.

J Gastrointest Surg 2019 Feb 12. Epub 2019 Feb 12.

Section of Hepatobiliary and Pancreatic Surgery, Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Background: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease.

Materials And Methods: We maintain a prospective high volume gastrointestinal malignancy PDX program. Read More

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http://dx.doi.org/10.1007/s11605-019-04109-zDOI Listing
February 2019
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Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma.

J Gastrointest Surg 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC).

Methods: All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor-node-metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Read More

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http://dx.doi.org/10.1007/s11605-019-04127-xDOI Listing
February 2019

Effects of Aspirin and Non-Steroidal Anti-Inflammatory Drugs on the Risk of Cholangiocarcinoma: A Meta-Analysis.

QJM 2019 Feb 7. Epub 2019 Feb 7.

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Mississippi, USA.

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) can suppress the proliferation of cholangiocarcinoma (CCA) cells in vitro through inhibition of cyclooxygenase-2. However, the effects of aspirin and NSAIDs on the risk of CCA remain unclear. We performed this meta-analysis to assess the risk of biliary tract cancers in patients who take aspirin and/or NSAIDs. Read More

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http://dx.doi.org/10.1093/qjmed/hcz039DOI Listing
February 2019
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Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials.

Medicina (Kaunas) 2019 Feb 8;55(2). Epub 2019 Feb 8.

Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy.

Cholangiocarcinoma (CCA) is a highly-aggressive malignancy arising from the biliary tree, characterized by a steady increase in incidence globally and a high mortality rate. Most CCAs are diagnosed in the advanced and metastatic phases of the disease, due to the paucity of signs and symptoms in the early stages. This fact, along with the poor results of the local and systemic therapies currently employed, is responsible for the poor outcome of CCA patients and strongly supports the need for novel therapeutic agents and strategies. Read More

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http://dx.doi.org/10.3390/medicina55020042DOI Listing
February 2019
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MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.

Cell Death Dis 2019 Feb 11;10(2):120. Epub 2019 Feb 11.

Department of Bioengineering and Therapeutic Sciences, and Liver Center, University of California, San Francisco, CA, USA.

PD901, a MEK inhibitor, has been demonstrated of therapeutic efficacy against cholangiocarcinoma (CCA) harboring K-Ras oncogenic mutations. However, most CCA exhibit no K-Ras mutations. In the current study, we investigated the therapeutic potential of PD901, either alone or in combination with the pan-mTOR inhibitor MLN0128, for the treatment of K-Ras wild-type CCA in vitro using human CCA cell lines, and in vivo using AKT/YapS127A CCA mouse model. Read More

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http://dx.doi.org/10.1038/s41419-019-1389-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370758PMC
February 2019
1 Read

Systematic review with meta-analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation.

Aliment Pharmacol Ther 2019 Feb 10. Epub 2019 Feb 10.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.

Background: After liver transplantation primary sclerosing cholangitis (PSC), the condition returns in the transplanted liver in a subset of patients (recurrent primary sclerosing cholangitis, rPSC).

Aim: To define risk factors for rPSC.

Methods: We searched Pubmed, Embase, Web of Science, and Cochrane library for articles published until March 2018. Read More

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http://dx.doi.org/10.1111/apt.15148DOI Listing
February 2019
2 Reads

Solitary ascending colon ulcer diagnosed as gastrointestinal CMV disease.

BMJ Case Rep 2019 Feb 9;12(2). Epub 2019 Feb 9.

Gastroenterology, University of Florida College of Medicine, Gainesville, Florida, USA.

A 42-year-old woman with a history of cholangiocarcinoma on adjuvant chemotherapy with capecitabine presented with painless haematochezia. She was found to have an isolated twenty-five mm ulcer in the ascending colon. Biopsies of the ulceration demonstrated typical cytomegalovirus (CMV) inclusions and her peripheral blood CMV PCR was significantly elevated. Read More

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http://dx.doi.org/10.1136/bcr-2018-226355DOI Listing
February 2019
2 Reads

Allogenic Vγ9Vδ2 T cell as new potential immunotherapy drug for solid tumor: a case study for cholangiocarcinoma.

J Immunother Cancer 2019 Feb 8;7(1):36. Epub 2019 Feb 8.

Biomedical Translational Research Institute and The First Affiliated Hospital, Jinan University, 601 W Ave Huangpu, Guangzhou, 510632, Guangdong, People's Republic of China.

Background: Cholangiocarcinoma (CCA) is a highly aggressive and fatal tumor. CCA occurs in the epithelial cells of bile ducts. Due to increasing incidences, CCA accounts for 3% of all gastrointestinal malignancies. Read More

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http://dx.doi.org/10.1186/s40425-019-0501-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368763PMC
February 2019
1 Read

Comparing the performance of urine and copro-antigen detection in evaluating Opisthorchis viverrini infection in communities with different transmission levels in Northeast Thailand.

PLoS Negl Trop Dis 2019 Feb 8;13(2):e0007186. Epub 2019 Feb 8.

Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

To combat and eventually eliminate the transmission of the liver fluke Opisthorchis viverrini, an accurate and practical diagnostic test is required. A recently established urine antigen detection test using monoclonal antibody-based enzyme-linked-immunosorbent assay (mAb-ELISA) has shown promise due to its high diagnostic accuracy and the use of urine in place of fecal samples. To further test the utility of this urine assay, we performed a cross sectional study of 1,043 people in 3 opisthorchiasis endemic communities in northeast Thailand by applying urine antigen detection together with copro-antigen detection methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007186DOI Listing
February 2019
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Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Suite 7717, 85 E Concord St, Boston, MA, 02118, USA.

Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. Read More

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http://dx.doi.org/10.1007/s10620-019-05484-yDOI Listing
February 2019
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Comparison of long-term efficacy between endoscopic and percutaneous biliary drainage for resectable extrahepatic cholangiocarcinoma with biliary obstruction: A systematic review and meta-analysis.

Saudi J Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University; Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Background/aim: For resectable extrahepatic cholangiocarcinoma with biliary obstruction, it remains a controversy whether to choose percutaneous transhepatic biliary drainage (PTBD) or endoscopic biliary drainage (EBD). A systematic review was conducted to compare the long-term efficacy between the two techniques.

Materials And Methods: Eligible studies were searched from January 1990 to May 2018, comparing the long-term efficacy between EBD and PTBD for extrahepatic cholangiocarcinoma. Read More

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http://dx.doi.org/10.4103/sjg.SJG_429_18DOI Listing
February 2019
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Systemic inflammation score predicts survival in patients with intrahepatic cholangiocarcinoma undergoing curative resection.

J Cancer 2019 1;10(2):494-503. Epub 2019 Jan 1.

Department of General Surgery, Zhongshan Hospital (South), Fudan University, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200083, China.

Inflammation has a critical role in the development and progression of cancers. We developed a novel systemic inflammation score (SIS) based on lymphocyte, monocyte, and CA19-9 and explored its prognostic value in intrahepatic cholangiocarcinoma (ICC). From January 2005 to December 2011, 322 consecutive ICC patients who underwent curative resection in our center were included in this study, and validated in a retrospective study of 126 patients enrolled from 2012 to 2014. Read More

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http://dx.doi.org/10.7150/jca.26890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360305PMC
January 2019

Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report.

Oncol Lett 2019 Feb 28;17(2):2069-2074. Epub 2018 Dec 28.

Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China.

Hilar cholangiocarcinoma is a highly malignant tumor and is currently treated by surgical resection or liver transplantation; however, these treatments result in poor patient prognosis accompanied with high recurrence and low patient mortality rates. Neoadjuvant therapy with liver transplantation is a novel treatment that exhibits promising clinical application, with a reported 5-year survival rate of 82%. However, transplantation centers conducting research into this treatment are limited due to its length and complexity. Read More

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http://dx.doi.org/10.3892/ol.2018.9878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350202PMC
February 2019
2 Reads

Intrahepatic bile duct exploration lithotomy is a useful adjunctive hepatectomy method for bilateral primary hepatolithiasis: an eight-year experience at a single centre.

BMC Surg 2019 Feb 4;19(1):16. Epub 2019 Feb 4.

Department of Hepatobiliary and Pancreatic surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: To evaluate the perioperative and long-term results of intrahepatic bile duct exploration lithotomy (IHBDIL) combined with hepatectomy for patients with complicated bilateral primary hepatolithiasis.

Methods: A study was conducted involving 56 patients with complicated bilateral primary hepatolithiasis who underwent IHBDIL combined with hepatectomy at our hospital from January 2006 to December 2014. The perioperative and long-term outcomes that were retrospectively analysed included the stone clearance rate, operative morbidity and mortality, and stone recurrence rate. Read More

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http://dx.doi.org/10.1186/s12893-019-0480-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360740PMC
February 2019
1 Read

YAP and TAZ Heterogeneity in Primary Liver Cancer: An Analysis of Its Prognostic and Diagnostic Role.

Int J Mol Sci 2019 Feb 1;20(3). Epub 2019 Feb 1.

Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, 3000 Leuven, Belgium.

Primary liver cancer comprises a diverse group of liver tumors. The heterogeneity of these tumors is seen as one of the obstacles to finding an effective therapy. The Hippo pathway, with its downstream transcriptional co-activator Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), has a decisive role in the carcinogenesis of primary liver cancer. Read More

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http://dx.doi.org/10.3390/ijms20030638DOI Listing
February 2019
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Anterograde bile duct drainage for intractable bile leakage after hepatectomy in a patient with previous pancreatoduodenectomy: A case report.

Int J Surg Case Rep 2019 Jan 29;55:121-124. Epub 2019 Jan 29.

Department of Surgery, Iwamizawa Municipal Hospital, 068-8555, Iwamizawa-shi, Japan.

Introduction: Endoscopic retrograde drainage is effective for managing bile leakage, which is relatively common after hepatectomy without bile duct reconstruction. However, the procedure is difficult to perform after pancreatoduodenectomy with choledochojejunostomy. We present a case of anterograde bile duct drainage for intractable bile leakage after hepatectomy in a patient with previous pancreatoduodenectomy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360323PMC
January 2019
2 Reads

Second Line Chemotherapy in Biliary Tract Cancer: Outcome and Prognostic Factors.

Liver Int 2019 Feb 4. Epub 2019 Feb 4.

Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.

Background & Aims: The prognosis of biliary tract cancer (BTC) is poor. Standard treatment for advanced BTC is a chemotherapy (CT) with gemcitabine and cisplatin. Phase-III evidence for a second line (2L) CT is lacking. Read More

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http://dx.doi.org/10.1111/liv.14063DOI Listing
February 2019
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Volumetric quantitative histogram analysis using diffusion-weighted magnetic resonance imaging to differentiate HCC from other primary liver cancers.

Abdom Radiol (NY) 2019 Feb 2. Epub 2019 Feb 2.

Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

Objective: To evaluate the ability of volumetric quantitative apparent diffusion coefficient (ADC) histogram parameters and LI-RADS categorization to distinguish hepatocellular carcinoma (HCC) from other primary liver cancers [intrahepatic cholangiocarcinoma (ICC) and combined HCC-ICC].

Methods: Sixty-three consecutive patients (44 M/19F; mean age 62 years) with primary liver cancers and pre-treatment MRI including diffusion-weighted imaging (DWI) were included in this IRB-approved single-center retrospective study. Tumor type was categorized pathologically. Read More

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http://dx.doi.org/10.1007/s00261-019-01906-7DOI Listing
February 2019
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Impact of Metabolic Parameters of F-Fluorodeoxyglucose Positron-emission Tomography After Hepatic Resection in Patients With Intrahepatic Cholangiocarcinoma.

Anticancer Res 2019 Feb;39(2):971-977

Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan.

Background: The aim of this study was to identify the prognostic impact of metabolic parameters of F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) in patients with intrahepatic cholangiocarcinoma (IHCC) undergoing hepatic resection.

Patients And Methods: Twenty-four patients with IHCC who underwent surgical resection were enrolled and F-FDG PET parameters maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured, as well as overall and recurrence-free survival.

Results: High TLG was significantly associated with large tumor size and high carbohydrate antigen 19-9 level. Read More

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http://dx.doi.org/10.21873/anticanres.13201DOI Listing
February 2019
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Absolute Neutrophil Count Predicts Postoperative Prognosis in Mass-forming Intrahepatic Cholangiocarcinoma.

Anticancer Res 2019 Feb;39(2):941-947

Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background/aim: Intrahepatic cholangiocarcinoma (IHCC) is characterized by poor prognosis, and postoperative recurrence remains a problem. Thus, prognostic markers for IHCC are greatly needed. Recently, inflammatory factors were reported to be related to tumor progression and recurrence in various cancers. Read More

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http://dx.doi.org/10.21873/anticanres.13197DOI Listing
February 2019
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Neuroendocrine Tumor of the Hilar Bile Duct.

Anticancer Res 2019 Feb;39(2):903-907

Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan

Neuroendocrine tumors usually develop in the gastrointestinal tract, pancreas, and lung. Therefore, a neuroendocrine tumor of the bile duct is quite rare. We present a 59-year-old-male patient whose preoperative diagnosis was hilar cholangiocarcinoma. Read More

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http://dx.doi.org/10.21873/anticanres.13192DOI Listing
February 2019
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Uncommon Intraluminal Tumors of the Gallbladder and Biliary Tract: Spectrum of Imaging Appearances.

Radiographics 2019 Feb 1:180164. Epub 2019 Feb 1.

From the Departments of Radiology (A.C., C.L.V., P.N., N.A.H., V.Y., F.H.M.) and Pathology (A.J.B., G.Y.Y.), Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 800, Chicago, IL 60611; Department of Radiology, Emory University School of Medicine, Atlanta, Ga (P.K.M.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

Intraluminal pathologic conditions of the bile ducts and gallbladder are common, most frequently consisting of calculi and adenocarcinoma. In recent years, intraductal papillary neoplasm of the bile ducts (IPN-B), which is analogous to intraductal papillary mucinous neoplasm of the pancreas, has been recognized as a distinct pathologic entity and a precursor lesion to adenocarcinoma of the bile ducts. Intraductal tubulopapillary neoplasm (ITPN) of the bile duct was subsequently described as a distinct pathologic entity. Read More

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http://dx.doi.org/10.1148/rg.2019180164DOI Listing
February 2019
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Concomitant adenosquamous carcinoma and cystadenocarcinoma of the extrahepatic bile duct: A case report.

World J Clin Cases 2019 Jan;7(2):215-220

Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Background: Infiltrative adenosquamous carcinoma (ASC) of the extrahepatic bile duct is reported infrequently, which is an unusual variant of the ordinary adenocarcinoma. The simultaneous development of ASC and cystadenocarcinoma in the extrahepatic biliary tree is rare. In addition, the accurate preoperative diagnosis of concomitant carcinoma in the multiple biliary trees at an early stage is often difficult. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i2.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354090PMC
January 2019
6 Reads

Role of digital single-operator cholangioscopy in the diagnosis and treatment of biliary disorders.

World J Gastrointest Endosc 2019 Jan;11(1):31-40

Department of Interventional Gastroenterology, Clinic of Gastroenterology, Acibadem City Clinic Tokuda Hopsital, Sofia 1407, Bulgaria.

Due to the need for improvement in the diagnosis and minimally invasive therapy of the bile duct disorders new technologies for cholangioscopy have been recently developed. Per-oral cholangioscopy has become an important diagnostic and therapeutic tool leading to avoidance of aggressive and unnecessary surgery in many clinical scenarios. This paper focuses on the newly developed SpyGlass DS technology, its advantages, and the technique of single-operator cholangioscopy (SOC), biliary indications and possible adverse events. Read More

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http://dx.doi.org/10.4253/wjge.v11.i1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354115PMC
January 2019
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Caval replacement with parietal peritoneum tube graft for septic thrombophlebitis after hepatectomy: A case report.

World J Hepatol 2019 Jan;11(1):133-137

Digestive Surgery, Toulouse University Hospital, Toulouse 31400, France.

Background: Caval vein thrombosis after hepatectomy is rare, although it increases mortality and morbidity. The evolution of this thrombosis into a septic thrombophlebitis responsible for persistent septicaemia after a hepatectomy has not been reported to date in the literature. We here report the management of a 54-year-old woman operated for a peripheral cholangiocarcinoma who developed a suppurated thrombophlebitis of the vena cava following a hepatectomy. Read More

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http://dx.doi.org/10.4254/wjh.v11.i1.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354118PMC
January 2019
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Treatment of primary sclerosing cholangitis in children.

World J Hepatol 2019 Jan;11(1):19-36

Department of Pediatrics, University of Utah, Salt Lake City, UT 84113, United States.

Primary sclerosing cholangitis (PSC) is a rare disease of stricturing and destruction of the biliary tree with a complex genetic and environmental etiology. Most patients have co-occurring inflammatory bowel disease. Children generally present with uncomplicated disease, but undergo a variable progression to end-stage liver disease. Read More

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http://dx.doi.org/10.4254/wjh.v11.i1.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354124PMC
January 2019
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Differentiating between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced MRI features: a systematic review and meta-analysis.

Authors:
M-W You S J Yun

Clin Radiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, Seoul 05278, Republic of Korea. Electronic address:

Aim: To identify magnetic resonance imaging (MRI) features for differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (IHCC) and summarise their diagnostic accuracy.

Materials And Methods: PubMed and EMBASE were searched for studies that employed MRI features to differentiate HCC from IHCC. Overlapping descriptors used to denote the same imaging finding in different studies were subsumed under a single feature. Read More

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http://dx.doi.org/10.1016/j.crad.2018.12.016DOI Listing
January 2019
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Early reoperation following pancreaticoduodenectomy: impact on morbidity, mortality, and long-term survival.

World J Surg Oncol 2019 Jan 31;17(1):26. Epub 2019 Jan 31.

Department of General Surgery B, Division of General Surgery, Tel-Aviv Sourasky, Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., 64239, Tel-Aviv, Israel.

Background: Reoperation following PD is a surrogate marker for a complex post-operative course and may lead to devastating consequences. We evaluate the indications for early reoperation following PD and analyze its effect on short- and long-term outcome.

Methods: Four hundred and thirty-three patients that underwent PD between August 2006 and June 2016 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12957-019-1569-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357503PMC
January 2019
2 Reads

Adjuvant chemotherapy improves oncological outcomes of resectable intrahepatic cholangiocarcinoma: A meta-analysis.

Medicine (Baltimore) 2019 Feb;98(5):e14013

Department of Surgery, Queen Mary Hospital.

Objective: To define the role of adjuvant chemotherapy in the management of resectable intrahepatic cholangiocarcinoma (ICC) by performing a meta-analysis.

Summary Background Data: Oncological benefit of adjuvant chemotherapy in resectable ICC remains controversial, high-level evidence in such context is lacking.

Method: A comprehensive search using Pubmed, EMbase, and Web of Science was performed from inception to October 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000014013DOI Listing
February 2019

Meta-analysis of the diagnostic value of Wisteria floribunda agglutinin-sialylated mucin1 and the prognostic role of mucin1 in human cholangiocarcinoma.

BMJ Open 2019 Jan 29;9(1):e021693. Epub 2019 Jan 29.

The First Clinical Medical School of Lanzhou University, Lanzhou, China.

Objective: Serum carbohydrate antigen 19-9 (CA19-9) is a widely used tumour marker for cholangiocarcinoma (CCA). However, it is not a necessarily good CCA marker in terms of diagnostic accuracy. The purpose of this study is to evaluate the diagnostic value of agglutinin-sialylated Mucin1 (WFA-MUC1) and the prognostic role of Mucin1 (MUC1) in human CCA. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02169
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http://dx.doi.org/10.1136/bmjopen-2018-021693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352767PMC
January 2019
7 Reads