1,439 results match your criteria Choanal Atresia


[Nasal endoscopic modified mucosal flap technique for repair of congenital choanal atresia in newborns and infants].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;56(7):713-718

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing 100045, China.

To describe and evaluate the surgical effect and prognosis of nasal endoscopic modified mucosal flap technique for repair of congenital choanal atresia in newborns and infants. The clinical data of 38 newborns and infants with congenital choanal atresia who underwent nasal endoscopic surgery in Beijing Children's Hospital between January 2016 and May 2018 were retrospectively analysed, including 13 males and 25 females. The age ranged from 5 days to 3 years old at the time of operation (15 cases were newborns). Read More

View Article and Full-Text PDF

The effectiveness of Mitomycin C in Otolaryngology procedures: A systematic review.

Clin Otolaryngol 2021 Jul 26. Epub 2021 Jul 26.

Division of Pediatric Otolaryngology-Head and Neck Surgery, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

Objective: Many studies have evaluated the effectiveness of topical intraoperative mitomycin (MCC) usage in a wide range of Otolaryngologic procedures with variable conclusions on effectiveness. This systematic review aims to provide a qualitative estimation of mitomycin C's treatment effectiveness in maintaining or preventing stenosis after surgical interventions.

Design And Main Outcome Measures: Following the PRISMA guideline, a comprehensive systematic search of MEDLINE, EMBASE, and CINAHL databases was performed including hand-searching and cross-reference checking. Read More

View Article and Full-Text PDF

[The efficacy of endoscopic plasty for children with bilateral congenital choanal atresia].

Authors:
Lu Liu Hongbing Yao

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;35(7):633-636

Department of Otorhinolaryngology,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics.

To evaluate the clinical effect of endoscopic repair for the treatment of children with bilateral congenital choanal atresia. A retrospective analysis was conducted in our department that six children who were diagnosed as bilateral congenital choanal atresia by nasopharyngeal endoscopy and nasal CT scanning. All cases underwent endoscopic repair and placed the silicone stent to support the enlarged nostrils for six months, and these patients were followed up to observe re-atresia rate after taking out of the supporting tube. Read More

View Article and Full-Text PDF

Synergistic role of retinoic acid signaling and Gata3 during primitive choanae formation.

Hum Mol Genet 2021 Jul 17. Epub 2021 Jul 17.

Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University.

Developmental defects of primitive choanae, an anatomical path to connect the embryonic nasal and oral cavity, result in disorders called choanal atresia, which are associated with many congenital diseases and require immediate clinical intervention after birth. Previous studies revealed that reduced retinoid signaling underlies the etiology of choanal atresia. In the present study, by using multiple mouse models which conditionally deleted Rdh10 and Gata3 during embryogenesis, we showed that Gata3 expression is regulated by retinoid signaling during embryonic craniofacial development and plays crucial roles for development of the primitive choanae. Read More

View Article and Full-Text PDF

A national study of choanal atresia in tertiary care centers in Canada - part II: clinical management.

J Otolaryngol Head Neck Surg 2021 Jul 13;50(1):46. Epub 2021 Jul 13.

Department of Paediatric Otolaryngology- Head and Neck Surgery, Children's Hospital at London Health Sciences Centre, London, ON, Canada.

Background: To evaluate the clinical management of choanal atresia (CA) in tertiary centers across Canada.

Methods: Multi-centre case series involving six tertiary care pediatric hospitals across Canada. Retrospective chart review of patients born between 1980 and 2010 diagnosed with choanal atresia to a participating center. Read More

View Article and Full-Text PDF

A national study of choanal atresia in tertiary care centers in Canada - part I: clinical presentation.

J Otolaryngol Head Neck Surg 2021 Jul 12;50(1):45. Epub 2021 Jul 12.

Department of Otolaryngology- Head and Neck Surgery, Children's Hospital at London Health Sciences Centre, London, ON, Canada.

Background: To evaluate the clinical presentation of choanal atresia (CA) in tertiary centers across Canada.

Methods: Multi-centre case series involving six tertiary care pediatric hospitals across Canada. Retrospective chart review of patients born between 1980 and 2010 diagnosed with CA at a participating center. Read More

View Article and Full-Text PDF

Transpalatal reconstruction and stenting for treatment of choanal atresia and nasopharyngeal stenosis in a dog.

J Am Vet Med Assoc 2021 Jul;259(2):190-196

Case Description: A 3-year-old 17.5-kg (38.5-lb) mixed-breed dog was referred for evaluation because of nasal discharge, sneezing, and signs of nasal congestion of approximately 9 months' duration. Read More

View Article and Full-Text PDF

Bilateral Choanal Atresia and Endoscopic Surgery: A Chance for CHARGE Patients.

J Clin Med 2021 Jun 30;10(13). Epub 2021 Jun 30.

Department of Neurosciences, Section of Otorhinolaryngology, University of Padova, 35128 Padova, Italy.

Bilateral choanal atresia (CA) is a rare congenital malformation frequently associated with other anomalies. CHARGE association is closely linked to bilateral CA. The aim of this study was to describe the outcomes of the endoscopic repair in bilateral CA, and to assess the role of postoperative nasal stenting in two cohorts of CHARGE-associated and non-syndromic CA. Read More

View Article and Full-Text PDF

Radiological Parameters Review for Choanal Atresia.

Pediatr Rep 2021 Jun 1;13(2):302-311. Epub 2021 Jun 1.

Radiology, Oncology, and Anatomopathological Department, University La Sapienza of Rome, 00185 Rome, Italy.

(1) Background: The study aims to identify which imaging parameters are necessary for a new correct surgical approach in the study of choanal atresia, and which anatomical findings are essential for correct planning of endoscopic treatment in choanal atresia. (2) Methods: In this retrospective study, 19 patients with choanal atresia had high-resolution multiplanar imaging (14 cases aged ≤1 year and 5 cases aged 1 to 3 years) and 35 patients in the control group similarly distributed by age. Fourteen variables, the most relevant from a surgical point of view, were selected and measured. Read More

View Article and Full-Text PDF

Transnasal Endoscopic Microdrilling with Steroid Douching for Bony Choanal Atresia: A Novel Approach.

Indian J Otolaryngol Head Neck Surg 2021 Jun 16;73(2):193-196. Epub 2021 Jan 16.

ENT-HNS, Sapthagiri Institute of Medical Sciences and Research Center, Hesarghatta Main Road, Chikkabanavara, Bengaluru, Karnataka 560090 India.

Unilateral Choanal Atresia is relatively an uncommon condition which goes undiagnosed even during adulthood. Detection of unilateral choanal atresia in adults is based on Clinical and Radiological Study. Pure Bony Atresia treated with Transnasal Endoscopic Microdrilling followed with Steroid Nasal Douching prevents restenosis. Read More

View Article and Full-Text PDF

Unilateral Choanal Atresia Presenting With Congenital Respiratory Distress and Recurrent Cyanotic Episodes.

Ear Nose Throat J 2021 May 28:1455613211020978. Epub 2021 May 28.

Pediatric Otorhinolaryngology Unit, 36739Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Congenital unilateral choanal atresia (CA) is not considered an emergent condition and should not cause respiratory distress in the newborn. Therefore, surgical repair of unilateral CA is usually delayed. This description of a newborn with congenital unilateral CA that caused significant respiratory distress, recurrent cyanotic episodes, and severe feeding difficulties highlights an exception to that rule. Read More

View Article and Full-Text PDF

Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling.

PLoS Genet 2021 May 25;17(5):e1009579. Epub 2021 May 25.

Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America.

We sought to understand how perturbation of signaling pathways and their targets generates variable phenotypes. In humans, GATA3 associates with highly variable defects, such as HDR syndrome, microsomia and choanal atresia. We previously characterized a zebrafish point mutation in gata3 with highly variable craniofacial defects to the posterior palate. Read More

View Article and Full-Text PDF

First trimester naproxen exposure and outcome of pregnancy - A German case series.

Reprod Toxicol 2021 08 17;103:51-57. Epub 2021 May 17.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Klinische Pharmakologie und Toxikologie, Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie, Germany.

In contrast to other non-steroidal anti-inflammatory drugs (NSAIDs), naproxen use during pregnancy is not well studied. The objective of this analysis was to assess negative effects on pregnancy outcomes following naproxen exposure in the first trimester of pregnancy. Out of 121 exposed pregnancies prospectively recorded by two German teratology information services (TIS) 15 ended as spontaneous abortion and ten were electively terminated; in one case for prenatal diagnosis of anencephaly. Read More

View Article and Full-Text PDF

Care of Children with DiGeorge Before and After Cultured Thymus Tissue Implantation.

J Clin Immunol 2021 Jul 18;41(5):896-905. Epub 2021 May 18.

Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.

Background: Children with complete DiGeorge anomaly (cDGA) have congenital athymia plus a myriad of other challenging clinical conditions. The term cDGA encompasses children with congenital athymia secondary to 22q11.2DS, CHARGE syndrome (coloboma, heart defects, choanal atresia, growth or mental retardation, genital abnormalities, and ear abnormalities and/or deafness), and other genetic abnormalities. Read More

View Article and Full-Text PDF

[Congenital complete bony unilateral atresia of the left choana in a 30-year-old woman].

Vestn Otorinolaringol 2021 ;86(2):90-92

State Budgetary Healthcare Institution of Moscow «City Clinical Hospital named after S.I. Spasokukotsky Department of Healthcare of Moscow», Moscow, Russia.

According to literature, the average age of children with unilateral atresia of the choan is six years nine months. Unilateral complete atresia of the choan makes it difficult to diagnose early: the initial diagnosis can be established in the second year of life and later, already at school age. In Russian and foreign literature in recent years, cases of diagnosing congenital atresia of choanomas in older children are known, the maximum age of children is 17-18 years, it is noted that such cases are very rare. Read More

View Article and Full-Text PDF

Development and validation of a normal tissue complication probability model for acquired nasal cavity stenosis and atresia after radical radiotherapy for nasopharyngeal carcinoma.

Radiother Oncol 2021 07 9;160:9-17. Epub 2021 Apr 9.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, China. Electronic address:

Purpose: Curative radiotherapy for nasopharyngeal carcinoma (NPC) can lead to acquired nasal cavity stenosis and atresia (ANCSA). As the first study to investigate risk factors of ANCSA in a large cohort of NPC patients, this article aims to develop and validate a multivariate normal tissue complication probability (NTCP) model to predict the development of ANCSA and to establish a nomogram for clinical use.

Methods And Materials: The retrospective cohort was comprised of 548 NPC patients treated with radical radiotherapy. Read More

View Article and Full-Text PDF

[A Newborn Suffering from Arhinia: Neonatologic Challenges During Primary Care of the Newborn With Bosma Arhinia Microphthalmia Syndrome (BAMS)].

Laryngorhinootologie 2021 04 30;100(4):294-296. Epub 2021 Mar 30.

Klinik für Neonatologie und Pädiatrische Intensivmedizin, Bürgerhospital Frankfurt, Frankfurt am Main.

The rare clinical picture of nasal agenesis is to be presented on the basis of a female newborn. Intrauterine growth restriction with polyhydramnios and midface hypoplasia were noted during pregnancy. Primary cesarean section at 38 + 4 weeks' gestation was done. Read More

View Article and Full-Text PDF

Features and Strategies in the Management of Choanal Atresia: A 6-Year Retrospective Analysis.

J Craniofac Surg 2021 Mar 22. Epub 2021 Mar 22.

Pediatric Otorhinolaryngology Department, "Agia Sofia" General Children's Hospital, Athens, Greece.

Introduction: Choanal atresia although rare, is the most common inborn nasal deformity and an important cause of newborn airway obstruction. This study aims to describe a single-center experience in the management of choanal atresia and emphasize the ambiguous issues regarding its surgical repair.

Patients And Methods: The authors retrospectively analyzed the treatment strategy of 18 patients with choanal atresia and their outcomes during the follow-up period. Read More

View Article and Full-Text PDF

[Features of the architectonics of the structures of the nasal cavity and choanal zone in children with congenital malformations of the eyes].

Vestn Otorinolaringol 2021 ;86(1):63-67

N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

The article provides data on the embryogenesis of the eyeball, nasolacrimal canal and nasal cavity. A frequent combination of congenital choanal atresia and anomalies in the development of the eyes was noted, most likely associated with the temporal and topographic parallelism of the intrauterine development of these anatomical areas. In order to assess the condition of the nasal cavity and choanal region in congenital eye pathology, 43 children with ophthalmological malformations were examined. Read More

View Article and Full-Text PDF

Endoscopic endonasal repair of complete bilateral choanal atresia in neonates.

Eur J Pediatr 2021 Jul 11;180(7):2245-2251. Epub 2021 Mar 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Reported success rates of endoscopic choanal atresia (CA) surgery vary substantially due to a high heterogeneity in and between study groups. Comprehensive data on the unique patient cohort of newborns with bilateral CA are scarce. Our study aimed to close this gap by using narrow inclusion criteria and standardized surgical outcome parameters. Read More

View Article and Full-Text PDF

Staged repair of truncus arteriosus with double aortic arch, tracheoesophageal fistula, and choanal atresia via a multi-disciplinary approach: a case report.

Transl Pediatr 2021 Feb;10(2):454-458

Division of Pediatric Cardiac Surgery, Department of Cardiovascular Surgery, The Mount Sinai Hospital, New York, NY, USA.

The previously unreported case of a child with an exceedingly rare amalgamation of complex defects, including truncus arteriosus (TA), double aortic arch (DAA), tracheoesophageal fistula, and choanal atresia is presented. First, on day-of-life (DOL) 2, with a joint effort involving Pediatric Cardiac Surgery, General Surgery, and Otolaryngology, division of tracheoesophageal fistula and repair of esophageal atresia, along with choanal atresia repair, was carried out. Via a right thoracotomy, the tracheoesophageal fistula, located medial to the azygous vein, was skeletonized and ligated. Read More

View Article and Full-Text PDF
February 2021

Congenital bony nasal cavity stenosis: A review of current trends in diagnosis and treatment.

Int J Pediatr Otorhinolaryngol 2021 May 6;144:110670. Epub 2021 Mar 6.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Congenital bony nasal cavity stenosis is caused by alterations of the normal embryological development of the nasal cavity. Depending on the site of the obstruction, the most important types of stenosis are: choanal atresia and stenosis, congenital nasal pyriform aperture stenosis, congenital midnasal stenosis, arhinia and nasal septum deviation. Although they are uncommon, they could be potentially life-threatening conditions that require early diagnosis and proper treatment. Read More

View Article and Full-Text PDF

Endonasal choanal atresia repair; evaluating the surgical results of 58 cases.

Turk J Pediatr 2021 ;63(1):136-140

Clinic of Otorhinolaryngology, Medicana International Ankara Hospital, Ankara, Turkey.

Background: Choanal atresia is the most common congenital nasal anomaly, with an incidence of 1:5000-1:8000 live births. Atresia can be seen as membraneous, bony or mixed type. When it is bilateral, it is accepted lifethreatening, therefore bilateral atresia necessitates immediate intervention. Read More

View Article and Full-Text PDF
January 2021

Prenatal Sonographic Features of CHARGE Syndrome.

Diagnostics (Basel) 2021 Feb 28;11(3). Epub 2021 Feb 28.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

CHARGE syndrome is a rare autosomal dominant disorder, associated with coloboma (C), heart defects (H), choanal atresia (A), retardation of growth and/or central nervous system (R), genitourinary anomalies (G) and ear abnormalities (E). Prenatal diagnosis of the syndrome is very rare but may be suspected when a combination of such abnormalities is identified. We describe a prenatally suspected case of CHARGE syndrome due to unique findings of cardiac defects (DORV) in combination with minor clues, including a structurally malformed ear with persistent non-response to an acoustic stimulation (which has never been prenatally described elsewhere), renal malrotation and growth restriction. Read More

View Article and Full-Text PDF
February 2021

Antenatal diagnosis of CHARGE syndrome: Prenatal ultrasound findings and crucial role of fetal dysmorphic signs. About a series of 10 cases and review of literature.

Eur J Med Genet 2021 Apr 2;64(4):104189. Epub 2021 Mar 2.

Center for Human Genetics, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium.

Although the prognosis of CHARGE syndrome can be highly variable from mild until severe, final diagnosis is difficult to establish in utero. The aim of our study is to compare antenatal and postnatal findings in a retrospective cohort of 10 successive patients with a positive CHD7 gene variant in order to identify the specific prenatal features for CHARGE syndrome diagnosis. Fetal ultrasound, follow-up and supplementary investigations are collected and compared to postnatal findings. Read More

View Article and Full-Text PDF

Bartsocas-Papas syndrome: The first case report of severe autosomal recessive form from Indonesia.

Int J Surg Case Rep 2021 Feb 27;79:436-439. Epub 2021 Jan 27.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Electronic address:

Introduction: Bartsocas-Papas syndrome (BPS) is an autosomal recessive form of Popliteal Pterygium syndrome (PPS). It is a very rare disease characterized by congenital craniofacial anomalies, popliteal webbing, and genitourinary and musculoskeletal anomalies. Almost all of the cases were reported in dead intrauterine pregnancies. Read More

View Article and Full-Text PDF
February 2021

Nasal Cavity CT Imaging Contribution to the Diagnosis and Treatment of Choanal Atresia.

Medicina (Kaunas) 2021 Jan 21;57(2). Epub 2021 Jan 21.

Department of Pediatric Otorhinolaryngology, Faculty of Medicine, Comenius University and National Institute of Children's Diseases, 83101 Bratislava, Slovakia.

Choanal atresia is the most common congenital malformation of the nose. We have evaluated 24 CT images of children with choanal atresia treated at the Department of Pediatric Otorhinolaryngology FM CU and the NICD Bratislava (Slovakia). In accordance with the methodology used by Slovis et al. Read More

View Article and Full-Text PDF
January 2021

[Causes of restenosis in the surgical treatment of congenital choanal atresia in children].

Vestn Otorinolaringol 2020 ;85(6):13-16

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.

This article presents the literature data and our own findings on the surgical treatment congenital atresia of the choanae (CAC) in children.

Aim: To find the causes of restenosis after a choanotomy in children with CAC.

Patients And Methods: We analyzed the results of surgical treatment of 144 children with the use of an endoscopic transnasal technique (=94) and without using endoscopy (=67). Read More

View Article and Full-Text PDF
January 2021

Optimizing Airway Surgery in COVID 19 Era.

Indian J Otolaryngol Head Neck Surg 2021 Jan 7:1-8. Epub 2021 Jan 7.

Department of Anaesthesiology, Pratiksha Hospital, Borbari, Mahapurush Madhabdev Path, Guwahati, Assam 781036 India.

Otorhinolaryngologists, particularly dealing with airway cases, are subjected to highest risk of COVID 19 aerosolisation, self infection and transmission. Moreover, airway cases, which mostly present as emergency, cannot be deferred. Being a tertiary airway centre and having received a number of airway cases, most of them requiring prompt surgical intervention, our airway surgery and anaesthesiology team had to work in conjunction to adapt and readapt the practice over the past few months, striving to achieve effective airway surgery protocols, to minimize exposure and prevent transmission of COVID 19. Read More

View Article and Full-Text PDF
January 2021

Neonatal nasal obstruction.

Eur Arch Otorhinolaryngol 2021 Jan 3. Epub 2021 Jan 3.

Otorhinolaryngology Unit, Hospital de Niños Roberto del Río, Santiago, Chile.

Purpose: Congenital nasal obstruction can be a significant cause of respiratory distress in the newborn, given that they are considered to be obligate nasal breathers. Several different causes have been described, which can be broadly classified as anatomical/malformative, non-tumoral masses and cysts, benign and malignant neoplasia, inflammatory/infectious, traumatic/iatrogenic, and miscellaneous. The purpose of this review is to provide updated and useful clinical information for teams involved in neonatal care, especially in a hospital setting. Read More

View Article and Full-Text PDF
January 2021