560 results match your criteria Chlamydial Pneumonias


Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues.

Front Microbiol 2019 4;10:113. Epub 2019 Feb 4.

The Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD, Australia.

are a genus of successful obligate intracellular pathogens spread across humans, wildlife, and domesticated animals. The most common species reported in livestock in this genus are , , , and . Chlamydial infections trigger a series of inflammatory disease-related sequelae including arthritis, conjunctivitis, pneumonia, and abortion. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369208PMC
February 2019
3 Reads

[Laboratory diagnosis of rare diseases].

Lakartidningen 2018 11 27;115. Epub 2018 Nov 27.

Klinisk kemi och Klinisk och experimentell medicin, Linköpings Universitet - Linköping , Sweden -.

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract which caters for a high predictive value in patients with symptoms and signs of community-acquired atypical pneumonias, provided optimal patient selection. Knowledge and awareness of treatable rare diseases amongst healthcare personnel combined with conveniently available cost-effective diagnostic techniques is essential for improvements in the handling of rare diseases. Read More

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November 2018
13 Reads

[Psittacosis - a forgotten diagnosis in Sweden?]

Lakartidningen 2018 11 27;115. Epub 2018 Nov 27.

Clinical Microbiology - Karolinska Universitetssjukhuset Solna, Sweden Clinical Microbiology - Karolinska Universitetssjukhuset Solna, Sweden.

Psittacosis, parrot fever, is an infectious disease caused by Chlamydophila psittaci, a common pathogen among birds. The clinical course ranges from a mild flu-like illness to severe disease that requires intensive care in humans. We report three cases of severe pneumonia where C. Read More

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November 2018
11 Reads

The Genetic Transformation of Chlamydia pneumoniae.

mSphere 2018 10 10;3(5). Epub 2018 Oct 10.

Department of Infectious Diseases and Microbiology, University of Luebeck, Luebeck, Germany

We demonstrate the genetic transformation of using a plasmid shuttle vector system which generates stable transformants. The equine N16 isolate harbors the 7.5-kb plasmid pCpnE1. Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphere.00412-18
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http://dx.doi.org/10.1128/mSphere.00412-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180227PMC
October 2018
13 Reads

Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles.

BMC Genomics 2018 Aug 2;19(1):575. Epub 2018 Aug 2.

Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Beutenbergstraße 11A, 07745, Jena, Germany.

Background: Members of the phylum Chlamydiae are obligate intracellular pathogens of humans and animals and have a serious impact on host health. They comprise several zoonotic species with varying disease outcomes and prevalence. To investigate differences in virulence, we focused on Chlamydia psittaci, C. Read More

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-018-4961-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090853PMC
August 2018
11 Reads

Inhibition of the Protein Phosphatase CppA Alters Development of Chlamydia trachomatis.

J Bacteriol 2018 Oct 10;200(19). Epub 2018 Sep 10.

Department of Microbiology, Southern Illinois University, Carbondale, Illinois, USA

Chlamydiae are obligate intracellular Gram-negative bacterial pathogens that undergo an essential, but poorly understood, biphasic developmental cycle transitioning between the infectious elementary body and the replicative reticulate body. Ser/Thr/Tyr phosphorylation has been increasingly recognized for its role in regulating bacterial physiology. spp. Read More

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http://dx.doi.org/10.1128/JB.00419-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148467PMC
October 2018
18 Reads

Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases.

Authors:
Seidu A Richard

Curr Neurovasc Res 2018 ;15(3):262-273

Department of Surgery, Volta Regional Hospital, P.O. Box MA-374, Ho, Ghana, West Africa.

Chlamydia Pneumoniae (C. Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. Read More

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http://dx.doi.org/10.2174/1567202615666180717161807DOI Listing
January 2018
16 Reads
2.253 Impact Factor

The p110δ isoforme of phosphatidylinositol 3-kinase plays an important role in host defense against chlamydial lung infection through influencing CD4+ T-cell function.

Pathog Dis 2018 08 1;76(6). Epub 2018 Aug 1.

Department of Immunology, Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba R3E0T5, Canada.

PI3Ks display integrant significance in T-cell development and differentiation, which is related to host defense against infections. Here, we investigated the role of p110δ isoform of PI3Ks in host defense against chlamydial lung infection in a mouse model. Our data showed that lung infection with Chlamydia muridarum (Cm) activated PI3K/AKT signaling pathway. Read More

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http://dx.doi.org/10.1093/femspd/fty053DOI Listing
August 2018
12 Reads

Influence of different delivery modes on the clinical characteristics of Chlamydia trachomatis pneumonia.

Eur J Pediatr 2018 Aug 31;177(8):1255-1260. Epub 2018 May 31.

Children's Hospital of Nanjing Medical University, Nanjing, China.

We analyzed the effects of delivery methods on Chlamydia trachomatis pneumonia in infants. Three hundred forty-four children hospitalized with Chlamydia trachomatis pneumonia were enrolled. They were divided into the vaginal delivery group and the cesarean delivery group. Read More

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http://dx.doi.org/10.1007/s00431-018-3147-5DOI Listing
August 2018
15 Reads

Identification of Chlamydia pneumoniae candidate genes that interact with human apoptotic factor caspase-9.

J Gen Appl Microbiol 2018 Nov 15;64(5):253-257. Epub 2018 May 15.

Graduate School of Biology-Oriented Science and Technology, Kindai University.

Chlamydia pneumoniae is an obligate intracellular pathogen responsible for respiratory diseases, including pneumonia and bronchitis, and is highly involved in chronic diseases, including atherosclerosis, asthma, and Alzheimer's disease. We previously showed that the host apoptotic factor caspase-9 played a crucial role for chlamydial multiplication and host apoptosis inhibition by chlamydial infection. To identify chlamydial genes interacting with human caspase-9, yeast two-hybrid screening was performed and 5 chlamydial genes, including Cpj0838 and pmpG were isolated from the C. Read More

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http://dx.doi.org/10.2323/jgam.2017.12.008DOI Listing
November 2018
17 Reads

Clinical and histologic features of Mycoplasma pneumoniae-related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes.

J Am Acad Dermatol 2018 Jul 17;79(1):110-117. Epub 2018 Mar 17.

Dermatology Department, Assistance Publique Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Créteil, France; Epidémiologie en Dermatologie et Evaluation des Thérapeutiques, Université Paris-Est Créteil (UPEC) Val de Marne, Créteil, France; Referral Center for Toxic Bullous Diseases, AP-HP, Henri Mondor Hospital, Créteil, France; UPEC, Créteil, France.

Background: Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniae-related EM have been poorly described in the literature.

Objective: To highlight differences between M pneumoniae EM and non-M pneumoniae EM. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.03.013DOI Listing
July 2018
11 Reads

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.

Expert Rev Vaccines 2018 03 6;17(3):217-227. Epub 2018 Feb 6.

a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.

Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

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http://dx.doi.org/10.1080/14760584.2018.1435279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330895PMC
March 2018
13 Reads

The role of zoonotic chlamydial agents in ruminants abortion.

Iran J Microbiol 2017 Oct;9(5):288-294

Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background And Objectives: Enzootic abortion of ewes (EAE) is caused by infection of sheep and goats by bacterium. Chlamydial abortion in bovine could occur by and is the causative agent of psittacosis or ornithosis disease in humans and birds. It also causes acute pneumonia in cattle and sheep. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748448PMC
October 2017
16 Reads

From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen.

BMC Genomics 2017 Dec 6;18(1):949. Epub 2017 Dec 6.

Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, People's Republic of China.

Background: Chlamydia (C.) gallinacea is a recently identified bacterium that mainly infects domestic chickens. Demonstration of C. Read More

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http://dx.doi.org/10.1186/s12864-017-4343-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717833PMC
December 2017
22 Reads

Frequency of detection of Chlamydophila pneumoniae using bronchoalveolar lavage fluid in patients with community-onset pneumonia.

Respir Investig 2017 Nov 22;55(6):357-364. Epub 2017 Sep 22.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki city, Nagasaki 852-8501, Japan. Electronic address:

Background: Chlamydophila pneumoniae is a causative pathogen of lower respiratory tract infection, which generally infects healthy, young people. However, it is often difficult to evaluate acute C. pneumoniae infection using upper respiratory tract specimens and/or sputum samples due to its persistent infection or colonization. Read More

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http://dx.doi.org/10.1016/j.resinv.2017.08.003DOI Listing
November 2017
13 Reads

The association between serological features of chronic Chlamydia pneumoniae infection and markers of systemic inflammation and nutrition in COPD patients.

Scand J Clin Lab Invest 2017 Dec 25;77(8):644-650. Epub 2017 Oct 25.

a Department of Internal Medicine, Pulmonary Diseases and Allergy , Medical University of Warsaw , Warsaw , Poland.

Introduction: Chlamydia pneumoniae is an obligatory human pathogen involved in lower and upper airway infections, including pneumonia, bronchitis. Asymptomatic C. pneumoniae carriage is also relatively common. Read More

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http://dx.doi.org/10.1080/00365513.2017.1393694DOI Listing
December 2017
30 Reads

Editorial: Clinical Manifestations, Microbiology, and Immunology.

Front Microbiol 2017 29;8:1916. Epub 2017 Sep 29.

Mycoplasmal and Chlamydial Infections in Humans, University of Bordeaux - INRA, USC EA 3671, Bordeaux, France.

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http://dx.doi.org/10.3389/fmicb.2017.01916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627267PMC
September 2017
11 Reads

Interventions for treating genital Chlamydia trachomatis infection in pregnancy.

Cochrane Database Syst Rev 2017 09 22;9:CD010485. Epub 2017 Sep 22.

Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Stellenbosch University and Tygerberg Hospital, PO Box 19063, Tygerberg, Western Cape, South Africa, 7505.

Background: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia. Read More

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http://dx.doi.org/10.1002/14651858.CD010485.pub2DOI Listing
September 2017
21 Reads

Lung US features of severe interstitial pneumonia: case report and review of the literature.

J Ultrasound 2017 Sep 11;20(3):247-249. Epub 2017 Feb 11.

Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Chlamydia pneumonia is reported to account for a relatively large number of cases of CAP. In elderly patients in particular, the clinical presentation can be a severe form of diffuse interstitial pneumonia. The chest X-ray presentation is aspecific. Read More

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http://dx.doi.org/10.1007/s40477-017-0241-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573697PMC
September 2017
5 Reads

Chlamydia gallinacea: a widespread emerging Chlamydia agent with zoonotic potential in backyard poultry.

Epidemiol Infect 2017 10 3;145(13):2701-2703. Epub 2017 Aug 3.

Department of Pathobiology,College of Veterinary Medicine, Auburn University,AL,USA.

Chlamydia gallinacea, a new chlamydial agent, has been reported in four European countries as well as Argentina and China. Experimentally infected chickens with C. gallinacea in previous study showed no clinical signs but had significantly reduced gains in body weight (6·5-11·4%). Read More

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http://dx.doi.org/10.1017/S0950268817001650DOI Listing
October 2017
13 Reads

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

Int J Antimicrob Agents 2017 Aug 6;50(2):247-251. Epub 2017 Jun 6.

Cerexa, Inc., Oakland, CA, USA.

Background: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment in atypical CAP.

Methods: Two phase 3, double-blind, comparative safety and efficacy studies of ceftaroline fosamil vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09248579173017
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http://dx.doi.org/10.1016/j.ijantimicag.2017.01.043DOI Listing
August 2017
36 Reads

Pharmaceutical Equivalence of Clarithromycin Oral Dosage Forms Marketed in Nairobi County, Kenya.

Sci Pharm 2017 Apr 26;85(2). Epub 2017 Apr 26.

National Quality Control Laboratory, P.O. Box 29726, Nairobi 00202, Kenya.

Clarithromycin is a broad-spectrum semi-synthetic macrolide indicated for treatment of pneumonias, , and chlamydial and skin infections. The object of this study was to evaluate the pharmaceutical equivalence of 14 generic clarithromycin products marketed in Nairobi County, Kenya, to the innovator products, using in vitro dissolution profiles and similarity factors (f₂). Further, dissolution profiles of four innovator formulations manufactured in different sites were compared. Read More

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http://dx.doi.org/10.3390/scipharm85020020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489924PMC
April 2017
9 Reads

Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.

J Bacteriol 2017 06 25;199(12). Epub 2017 May 25.

Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, USA

Chaperonins are essential for cellular growth under normal and stressful conditions and consequently represent one of the most conserved and ancient protein classes. The paradigm chaperonin, EcGroEL, and its cochaperonin, EcGroES, assist in the folding of proteins via an ATP-dependent mechanism. In addition to the presence of and homologs, paralogs are found in many bacteria, including pathogens, and have evolved poorly understood species-specific functions. Read More

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http://dx.doi.org/10.1128/JB.00844-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446618PMC
June 2017
12 Reads

High Prevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in Children with Acute Respiratory Infections from Lima, Peru.

PLoS One 2017 27;12(1):e0170787. Epub 2017 Jan 27.

Centre de Biotecnologia Molecular (CEBIM), Departament d'Enginyeria Química, ETSEIB, Universitat Politècnica de Catalunya (UPC) Barcelona Tech, Barcelona, Spain.

Background: Mycoplasma pneumoniae and Chlamydia pneumoniae are atypical pathogens responsible for pneumonia and a leading cause of morbidity and mortality in low income countries. The study objective is to determine the prevalence of this pathogens in Peruvian children with acute respiratory infections.

Methods: A consecutive cross-sectional study was conducted in Lima, Peru from May 2009 to September 2010. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170787PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271412PMC
August 2017
10 Reads

Acanthamoeba containing endosymbiotic chlamydia isolated from hospital environments and its potential role in inflammatory exacerbation.

BMC Microbiol 2016 Dec 15;16(1):292. Epub 2016 Dec 15.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University Graduate School of Health Sciences, Nishi-5 Kita-12 Jo, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan.

Background: Environmental chlamydiae belonging to the Parachlamydiaceae are obligate intracellular bacteria that infect Acanthamoeba, a free-living amoeba, and are a risk for hospital-acquired pneumonia. However, whether amoebae harboring environmental chlamydiae actually survive in hospital environments is unknown. We therefore isolated living amoebae with symbiotic chlamydiae from hospital environments. Read More

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http://dx.doi.org/10.1186/s12866-016-0906-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5160005PMC
December 2016
5 Reads

Lack of association of Chlamydia pneumoniae with cardiovascular diseases in virologically suppressed HIV patients.

New Microbiol 2017 Jan 7;40(1):33-37. Epub 2016 Nov 7.

Department of Molecular Medicine, "Sapienza" University of Rome.

Cardiovascular disease (CVD) is a major public health problem in developed countries with over 17 million deaths per year. In the last decade, several infectious agents rather than any single pathogen, including Chlamydia pneumoniae and human immunodeficiency virus (HIV), have been shown to contribute to the development of atherosclerosis and subsequent cardiovascular events by inducing systemic inflammation and/or acting directly on the vascular wall. For the first time, we evaluated C. Read More

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January 2017
10 Reads

Birds of a feather: an uncommon cause of pneumonia and meningoencephalitis.

BMJ Case Rep 2016 Sep 12;2016. Epub 2016 Sep 12.

Department of Microbiology, UHCW, Coventry, UK Department of Microbiology, George Eliot Hospital NHS Trust, Nuneaton, Warwickshire, UK.

A 61-year-old man was admitted with a 1-week history of influenza-like symptoms during a period of increased influenza virus activity. He soon developed type 2 respiratory failure and became increasingly drowsy. He later suffered a convulsive episode in the intensive care unit (ICU) which self-terminated. Read More

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http://dx.doi.org/10.1136/bcr-2016-216879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030533PMC
September 2016
7 Reads

Pneumonia due to Chlamydia pecorum in a Koala (Phascolarctos cinereus).

J Comp Pathol 2016 Nov 24;155(4):356-360. Epub 2016 Aug 24.

School of Life and Environmental Sciences, Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia.

Chlamydiosis is a common infectious disease of koalas (Phascolarctos cinereus), but Chlamydia spp. have not yet been demonstrated to cause pneumonia in these animals. A juvenile male koala died following an episode of respiratory disease. Read More

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http://dx.doi.org/10.1016/j.jcpa.2016.07.011DOI Listing
November 2016
10 Reads

Impact of micro-environmental changes on respiratory tract infections with intracellular bacteria.

FEBS Lett 2016 Nov 11;590(21):3887-3904. Epub 2016 Sep 11.

Department of Infectious Diseases and Microbiology, University of Lübeck, Germany.

Community-acquired pneumonia is caused by intra- and extracellular bacteria, with some of these bacteria also being linked to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease. Chlamydia pneumoniae is an obligate intracellular pathogen that is highly sensitive to micro-environmental conditions controlling both pathogen growth and host immune responses. The availability of nutrients, as well as changes in oxygen, pH and interferon-γ levels, have been shown to directly influence the chlamydial life cycle and clearance. Read More

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http://dx.doi.org/10.1002/1873-3468.12353DOI Listing
November 2016
16 Reads

Mycoplasma pneumoniae: Current Knowledge on Macrolide Resistance and Treatment.

Front Microbiol 2016 22;7:974. Epub 2016 Jun 22.

USC EA 3671 Mycoplasmal and Chlamydial Infections in Humans, Univ. BordeauxBordeaux, France; USC EA 3671 Mycoplasmal and Chlamydial Infections in Humans, INRABordeaux, France; Laboratoire de Bactériologie, Centre Hospitalier Universitaire de BordeauxBordeaux, France.

Mycoplasma pneumoniae causes community-acquired respiratory tract infections, particularly in school-aged children and young adults. These infections occur both endemically and epidemically worldwide. M. Read More

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http://dx.doi.org/10.3389/fmicb.2016.00974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916212PMC
July 2016
11 Reads

Chronic Infection and Severe Asthma.

Immunol Allergy Clin North Am 2016 08 2;36(3):483-502. Epub 2016 Jun 2.

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.

Chronic bacterial infection is implicated in both the development and severity of asthma. The atypical bacteria Mycoplasma pneumoniae and Chlamydophila pneumoniae have been identified in the airways of asthmatics and correlated with clinical features such as adult onset, exacerbation risks, steroid sensitivity, and symptom control. Asthmatic patients with evidence of bacterial infection may benefit from antibiotic treatment directed towards these atypical organisms. Read More

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http://dx.doi.org/10.1016/j.iac.2016.03.010DOI Listing
August 2016
6 Reads

Chlamydia-host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaci.

FEBS Lett 2016 Nov 26;590(21):3920-3940. Epub 2016 Jul 26.

Friedrich-Loeffler-Institut, Institute of Immunology, Isle of Riems, Germany.

Chlamydia psittaci causes psittacosis/ornithosis in birds and is an economically important pathogen for poultry farming. It also infects nonavian domestic animals as well as rodents, and is a zoonotic human pathogen responsible for atypical pneumonia. The bacterium efficiently disseminates in host organisms causing pulmonary and systemic disease. Read More

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http://dx.doi.org/10.1002/1873-3468.12295DOI Listing
November 2016
11 Reads

Interrogating Genes That Mediate Chlamydia trachomatis Survival in Cell Culture Using Conditional Mutants and Recombination.

J Bacteriol 2016 08 13;198(15):2131-9. Epub 2016 Jul 13.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Unlabelled: Intracellular bacterial pathogens in the family Chlamydiaceae are causes of human blindness, sexually transmitted disease, and pneumonia. Genetic dissection of the mechanisms of chlamydial pathogenicity has been hindered by multiple limitations, including the inability to inactivate genes that would prevent the production of elementary bodies. Many genes are also Chlamydia-specific genes, and chlamydial genomes have undergone extensive reductive evolution, so functions often cannot be inferred from homologs in other organisms. Read More

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http://dx.doi.org/10.1128/JB.00161-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944222PMC
August 2016
29 Reads

Prognostic value of TH1/TH2 cytokines in infants with wheezing in a three year follow-up study.

Pneumonol Alergol Pol 2016 ;84(3):144-50

Introduction: The immune system is known to play a key role in the development of viral-induced wheeze, but the pattern of cytokine response is not clear. The aim of the study was to determine whether plasma cytokine levels during the acute wheezing illness in infants are associated with the subsequent development of persistent recurrent wheezing (PRW).

Material And Methods: 43 infants admitted to Iashvili Central Children Hospital, Tbilisi, Georgia, were selected. Read More

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http://dx.doi.org/10.5603/PiAP.2016.0016DOI Listing
April 2017
12 Reads

Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine.

Curr Clin Microbiol Rep 2016;3:10-18. Epub 2016 Feb 3.

Department of Biomedical Sciences, Center of Excellence for Inflammation, Infectious Disease and Immunity, Box 70579, Quillen College of Medicine, East Tennessee State University, Box 70579, Johnson City, TN 37614-0579 USA.

The are widespread pathogens of both humans and animals. infection causes blinding trachoma and reproductive complications in humans. causes human respiratory tract infections and atypical pneumonia. Read More

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http://dx.doi.org/10.1007/s40588-016-0028-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845085PMC
February 2016
12 Reads

[Chlamydia trachomatis infection in mother and child; the importance of a complete history and efficient interdisciplinary communication].

Ned Tijdschr Geneeskd 2016 ;160:A9727

St. Antonius Ziekenhuis, afd. Kindergeneeskunde, Nieuwegein.

General practitioners and paediatricians are frequently confronted with coughing infants. The age of the infant, the history of both mother and child, as well as the current maternal condition may provide important diagnostic information. A 4-week-old male infant was referred to the paediatrician with a persistent cough. Read More

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December 2016
5 Reads

Chlamydia trachomatis Infection in Pregnancy: The Global Challenge of Preventing Adverse Pregnancy and Infant Outcomes in Sub-Saharan Africa and Asia.

Biomed Res Int 2016 6;2016:9315757. Epub 2016 Apr 6.

Department of Medicine, Division of Infectious Diseases: Global Health, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, UCLA, Los Angeles, CA 90024, USA.

Screening and treatment of sexually transmitted infections (STIs) in pregnancy represents an overlooked opportunity to improve the health outcomes of women and infants worldwide. Although Chlamydia trachomatis is the most common treatable bacterial STI, few countries have routine pregnancy screening and treatment programs. We reviewed the current literature surrounding Chlamydia trachomatis in pregnancy, particularly focusing on countries in sub-Saharan Africa and Asia. Read More

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http://dx.doi.org/10.1155/2016/9315757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837252PMC
February 2017
16 Reads

Chlamydia pneumoniae, and mycoplasma pneumoniae: Are they related to severe asthma in childhood?

J Asthma 2016 08 27;53(6):618-21. Epub 2016 Apr 27.

a Emergency Department , Clinical Hospital, Pediatric Department National University of Asuncion , San Lorenzo , Paraguay.

Background: Mycoplasma pneumoniae and Chlamydia pneumoniae are frequent agents of acute respiratory diseases and they have been recognized as infectious triggers of asthma.

Objective: To determine the frequency of these triggers and their relationship to severe asthma.

Methods: 82 patients were enrolled in a prospective cross-sectional study from January 2007 to March 2013 and they were divided into three study groups: Group 1: 27 children with severe asthma, Group 2: 29 children with stable asthma and Group 3: 26 children which was the control group. Read More

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http://dx.doi.org/10.3109/02770903.2015.1116085DOI Listing
August 2016
6 Reads

Eosinophilia in Preterm Born Infants Infected with Chlamydia trachomatis.

Fetal Pediatr Pathol 2016 11;35(3):149-58. Epub 2016 Apr 11.

a National Institute of Perinatology, Infectology , Montes Urales 800, Col Lomas Virreyes, Mexico City , 11000 Mexico.

A higher than 350 eosinophils/mm(3) is strongly associated with Chlamydia trachomatis in term born babies coursing with respiratory distress. However, in preterm newborns infected with this pathogen, the levels of eosinophils are unknown. Forty newborn infants with clinical data of respiratory problems and/or sepsis were analyzed. Read More

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http://dx.doi.org/10.3109/15513815.2016.1153175DOI Listing
March 2017
9 Reads

Role of Chlamydia pneumoniae in community-acquired pneumonia in hospitalized Jordanian adults.

J Infect Dev Ctries 2016 Mar 31;10(3):227-36. Epub 2016 Mar 31.

Faculty of Science, the University of Jordan, Amman, Jordan.

Introduction: This study investigated the role of Chlamydia pneumoniae in the etiology of community-acquired pneumonia (CAP) in Jordanian adults.

Methodology: Eighty hospitalized CAP patients and 110 healthy adults were enrolled. Overall prevalences of C. Read More

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http://dx.doi.org/10.3855/jidc.6590DOI Listing
March 2016
8 Reads
2 Citations
1.270 Impact Factor

[Analysis of the etiology of hemoptysis and its diagnosis and treatment in 106 cases].

Zhonghua Er Ke Za Zhi 2016 Feb;54(2):137-40

Department of Pulmonology, The Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou 325027, China.

Objective: To investigate the etiology and clinical manifestation of hemoptysis in children.

Method: A retrospective analysis was performed for 106 cases of hemoptysis who were admitted to The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University from January 2005 to December 2014.The clinical information including laboratory tests and image data were collected and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2016.02.013DOI Listing
February 2016
77 Reads

[Bronchopulmonary infections caused by atypical pathogens in children : Myth or reality?]

Rev Med Brux 2016;37(4):331-337

Service de Pédiatrie, Hôpital Erasme, ULB, Route de Lennik 808, Bruxelles, Belgium.

Mycoplasma pneumoniae and Chlamydia pneumoniae are the most common atypical pathogens seen in respiratory infections in children. Currently, the management of atypical pneumonia due to these pathogens is blurry. The clinical features are hardly specific ; it appears that M. Read More

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January 2019
2 Reads

Assessment of Chlamydia psittaci Shedding and Environmental Contamination as Potential Sources of Worker Exposure throughout the Mule Duck Breeding Process.

Appl Environ Microbiol 2015 Dec 28;82(5):1504-1518. Epub 2015 Dec 28.

University Paris-Est, ANSES Animal Health Laboratory, Bacterial Zoonoses Unit, Maisons-Alfort, France

Chlamydia psittaci is an obligate intracellular bacterium responsible for avian chlamydiosis, otherwise known as psittacosis, a zoonotic disease that may lead to severe atypical pneumonia. This study was conducted on seven mule duck flocks harboring asymptomatic birds to explore the circulation and persistence of C. psittaci during the entire breeding process and assess the potential sources of worker exposure. Read More

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http://dx.doi.org/10.1128/AEM.03179-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771335PMC
December 2015
22 Reads

An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions.

Pathog Dis 2016 Mar 15;74(2). Epub 2015 Dec 15.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, D-30625 Hannover, Germany

Chlamydia trachomatis causes sexually transmitted diseases with infertility, pelvic inflammatory disease and neonatal pneumonia as complications. The duration of urogenital mouse models with the strict mouse pathogen C. muridarum addressing vaginal shedding, pathological changes of the upper genital tract or infertility is rather long. Read More

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http://femspd.oxfordjournals.org/content/femspd/early/2015/1
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http://dx.doi.org/10.1093/femspd/ftv120DOI Listing
March 2016
9 Reads

Assessment of Chlamydia suis Infection in Pig Farmers.

Transbound Emerg Dis 2017 Jun 18;64(3):826-833. Epub 2015 Nov 18.

Lab of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, University of Ghent, Ghent, Belgium.

Chlamydia suis infections are endemic in domestic pigs in Europe and can lead to conjunctivitis, pneumonia, enteritis and reproductive failure. Currently, the knowledge on the zoonotic potential of C. suis is limited. Read More

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http://dx.doi.org/10.1111/tbed.12446DOI Listing
June 2017
8 Reads

Comparative "-omics" in Mycoplasma pneumoniae Clinical Isolates Reveals Key Virulence Factors.

PLoS One 2015 3;10(9):e0137354. Epub 2015 Sep 3.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluis Companys 23, Barcelona, Spain.

The human respiratory tract pathogen M. pneumoniae is one of the best characterized minimal bacterium. Until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the sequence of the P1 adhesin gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137354PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559472PMC
May 2016
26 Reads

NK cells modulate the lung dendritic cell-mediated Th1/Th17 immunity during intracellular bacterial infection.

Eur J Immunol 2015 Oct 24;45(10):2810-20. Epub 2015 Aug 24.

Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

The impact of the interaction between NK cells and lung dendritic cells (LDCs) on the outcome of respiratory infections is poorly understood. In this study, we investigated the effect and mechanism of NK cells on the function of LDCs during intracellular bacterial lung infection of Chlamydia muridarum in mice. We found that the naive mice receiving LDCs from C. Read More

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http://dx.doi.org/10.1002/eji.201445390DOI Listing
October 2015
9 Reads

Molecular Epidemiology of Mycoplasma pneumoniae: Genotyping Using Single Nucleotide Polymorphisms and SNaPshot Technology.

J Clin Microbiol 2015 Oct 22;53(10):3182-94. Epub 2015 Jul 22.

University of Bordeaux, USC EA3671 Mycoplasmal and Chlamydial Infections in Humans, Bordeaux, France INRA, USC EA3671 Mycoplasmal and Chlamydial Infections in Humans, Bordeaux, France Bacteriology Department, Bordeaux University Hospital, Bordeaux, France

Molecular typing of Mycoplasma pneumoniae is an important tool for identifying grouped cases and investigating outbreaks. In the present study, we developed a new genotyping method based on single nucleotide polymorphisms (SNPs) selected from the whole-genome sequencing of eight M. pneumoniae strains, using the SNaPshot minisequencing assay. Read More

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http://dx.doi.org/10.1128/JCM.01156-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572556PMC
October 2015
4 Reads

Intratracheal infection as an efficient route for testing vaccines against Chlamydia abortus in sheep.

Vet J 2015 Sep 5;205(3):393-8. Epub 2015 May 5.

Departamento de Sanidad Animal, Facultad de Veterinaria, Regional Campus of International Excellence 'Campus Mare Nostrum', Universidad de Murcia, Spain. Electronic address:

Pregnant ewes have been widely used to test vaccines against Chlamydia abortus. However, this model entails many disadvantages such as high economic costs and long periods of pregnancy. The murine model is very useful for specific studies but cannot replace the natural host for the later stages of vaccine evaluation. Read More

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http://dx.doi.org/10.1016/j.tvjl.2015.04.036DOI Listing
September 2015
6 Reads

Three cases of atypical pneumonia caused by Chlamydophila psittaci.

Hong Kong Med J 2015 Jun;21(3):272-5

Department of Pathology, United Christian Hospital, Kwun Tong, Hong Kong.

Psittacosis is a zoonotic disease caused by Chlamydophila psittaci. The most common presentation is atypical pneumonia. Three cases of pneumonia of varying severity due to psittacosis are described. Read More

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http://dx.doi.org/10.12809/hkmj144321DOI Listing
June 2015
8 Reads