Search Our Scientific Publications & Authors

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 Apr;40(4):300-303

Shandong Academy of Occupational Health and Occupational Medicine Occupational Pulmonary Disease Department, Jinan 250001, China.

This paper reported a case of severe Chlamydia psittaci pneumonia. The patient had a clear history of contact with sick poultry. The clinical manifestations were dry cough, fever and respiratory failure. Read More

BMC Pulm Med 2021 Nov 22;21(1):380. Epub 2021 Nov 22.

Third Department of Medicine, School of Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, 152 Mesogion Avenue, 11527, Athens, Greece.

Background: Chlamydia pneumoniae is a common cause of atypical community acquired pneumonia (CAP). The diagnostic approach of chlamydial infections remains a challenge. Diagnosis of delayed chlamydial-associated complications, involving complex autoimmune pathophysiological mechanisms, is still more challenging. Read More

JAMA 2021 09;326(10):949-956

Tufts University School of Medicine, Boston, Massachusetts.

Importance: Chlamydia and gonorrhea are among the most common sexually transmitted infections in the US. Infection rates are highest among adolescents and young adults of both sexes. Chlamydial and gonococcal infections in women are usually asymptomatic and may lead to pelvic inflammatory disease and its associated complications. Read More

Pathogens 2021 Jul 7;10(7). Epub 2021 Jul 7.

Laboratory for Immunology and Animal Biotechnology, Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.

() resides in the intestines of pigs and tetracycline-resistant strains are emerging worldwide. Intestinal infections are often subclinical. However, the gut is regarded as a reservoir and clinical infections have been associated with enteritis, conjunctivitis, pneumonia and reproductive failure. Read More

BMC Infect Dis 2021 Jun 30;21(1):621. Epub 2021 Jun 30.

Medical Intensive Care Unit, Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.

Background: Psittacosis, which is also known as parrot fever, is Chlamydia psittaci (C. psittaci) caused infectious disease. The clinical manifestations vary from asymptomatic infection to severe atypical pneumonia or even fatal meningitis. Read More

Front Public Health 2021 10;9:531073. Epub 2021 Jun 10.

Division of Disease Prevention, Policy and Global Health, Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, United States.

infection has been associated with adverse pregnancy and neonatal outcomes such as premature rupture of membranes, preterm birth, low birth weight, conjunctivitis, and pneumonia in infants. This review evaluates existing literature to determine potential benefits of antenatal screening and treatment of in preventing adverse outcomes. A literature search revealed 1824 studies with 156 full-text articles reviewed. Read More

Microorganisms 2021 Apr 27;9(5). Epub 2021 Apr 27.

Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 842 15 Bratislava, Slovakia.

Chlamydia are Gram-negative, intracellular pathogens colonizing epithelial mucosa. They cause primarily atypical pneumonia and have recently been associated with chronic diseases. Diagnostics relies almost exclusively on serological methods; PCR tests are used rarely because in patients with positive ELISA, it is nearly impossible to identify chlamydial DNA. Read More

BMC Infect Dis 2021 Mar 17;21(1):270. Epub 2021 Mar 17.

Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave., Box 49, Brooklyn, NY, 11203, USA.

Background: Neonatal ocular prophylaxis with silver nitrate does not prevent neonatal conjunctivitis due to Chlamydia trachomatis. The efficacy of antibiotic containing preparations for prevention of neonatal chlamydial conjunctivitis (NCC) has not been established.

Objective: To examine published literature to determine whether antibiotic containing preparation are efficacious for prevention of NCC and C. Read More

Indian J Med Microbiol 2020 Jul-Dec;38(3 & 4):338-343

Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman, Jordan.

Purpose: Chlamydia pneumoniae is associated with human respiratory diseases. Few reports examined the involvement of this bacterium in community-acquired pneumonia (CAP) in Jordan. This study investigates for the first time the role of C. Read More

mSphere 2020 08 26;5(4). Epub 2020 Aug 26.

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.

The obligate intracellular bacterium is a known avian pathogen causing psittacosis in birds and is capable of zoonotic transmission. In human pulmonary infections, can cause pneumonia associated with significant mortality if inadequately diagnosed and treated. Although intracellular manipulates host cell organelles for its replication and survival, it has been difficult to demonstrate host-pathogen interactions in infection due to the lack of easy-to-handle genetic manipulation tools. Read More

Infection 2020 Dec 28;48(6):871-877. Epub 2020 Jul 28.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Introduction: The novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co-infections with other respiratory pathogens, with viral co-infection being the most representative agents. Co-infection with Mycoplasma pneumoniae has been described both in adults and pediatrics whereas only two cases of Chlamydia pneumoniae have been reported in a large US study so far. Read More

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Adolescent and Child Health, Mater Dei Hospital, Msida, Malta.

We report an unusual case of an 11-day-old neonate presenting with haemolacria on a background of sticky conjunctival discharge. This was secondary to pseudomembranous conjunctivitis which responded well to systemic erythromycin. Early appropriate treatment is important to prevent progression of the ophthalmic infection, which could lead to blindness, and to prevent other manifestations of neonatal chlamydial infection, particularly pneumonia, which could be fatal. Read More

Cell Immunol 2020 07 16;353:104132. Epub 2020 May 16.

Departments of Immunology and Medical Microbiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada. Electronic address:

Protective immune response to chlamydial infection is largely dependent on cell-mediated immune responses with IFN-γ production. Recent studies have shown the critical role of NK cells in bridging innate and adaptive immune responses. In this study, we investigated the effect of NK cells on T cell responses during Chlamydophila pneumoniae (Cpn) lung infection. Read More

Int J Mol Sci 2020 Apr 17;21(8). Epub 2020 Apr 17.

Institute for Molecular Pathogenesis, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Naumburgerstr. 96a, 07743 Jena, Germany.

Pneumonia is a cause of high morbidity and mortality in humans. Animal models are indispensable to investigate the complex cellular interactions during lung injury and repair in vivo. The time sequence of lesion development and regeneration is described after endobronchial inoculation of calves with Calves were necropsied 2-37 days after inoculation (dpi). Read More

ACS Sens 2020 04 1;5(4):1140-1148. Epub 2020 Apr 1.

College of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

is a spherical zoonotic pathogen with a diameter of ∼200 nm, which can lead to a wide range of acute and chronic diseases in human body. Early and reliable on-site detection of is the key step to control the spread of the pathogen. However, the lack of a current technology with advantages of rapidity, ultrasensitivity, and convenience limits the implementation of traditional techniques for on-site detection of . Read More

Paediatr Int Child Health 2020 08 13;40(3):207-210. Epub 2020 Feb 13.

Departments of Paediatrics, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara, Turkey.

Chlamydophila Pneumoniae: , a common cause of respiratory tract infections, rarely leads to serious conditions. A 13-year-old boy with serologically confirmed infection presented with pneumonia complicated by pericardial and bilateral pleural effusions. He had a large haemorrhagic pericardial effusion from which 1000 ml of fluid was aspirated over 10 days and a right haemorrhagic pleural effusion which required a chest drain and the removal of 700 ml over 5 days. Read More

Avian Pathol 2020 Jun 12;49(3):251-260. Epub 2020 Mar 12.

College of Life Science and Engineering, Foshan University, Foshan, People's Republic of China.

is an important zoonotic pathogen and its oral route of infection plays an important role in the transmission and persistence. strain, a common contaminant of animal feed and feedstuffs, can cause severe diarrhoea and malnutrition in poultry. In our previous study, a strain (Dawu C), isolated from the haemorrhagic lungs of infected chickens, was shown to harbour two virulence genes () and was able to induce haemorrhagic lesions in the lungs, as well as gizzard erosion and ulceration (GEU) syndrome in broilers. Read More

J Infect Chemother 2019 Dec 20;25(12):987-994. Epub 2019 Jun 20.

Department of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan.

The obligate intracellular bacteria chlamydia is major human pathogen that causes millions of trachoma, sexually transmitted infections and pneumonia worldwide. We serendipitously found that both calpain inhibitors z-Val-Phe-CHO and z-Leu-Nle-CHO showed marked inhibitory activity against chlamydial growth in human epithelial HeLa cells, whereas other calpain inhibitors not. These peptidomimetic inhibitors consist of N-benzyloxycarbonyl group and hydrophobic dipeptide derivatives. Read More

Dis Aquat Organ 2019 Jan;132(3):203-208

Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, Italy.

This study reports gross, histopathological, and molecular features of a Chlamydia abortus infection in a stranded female striped dolphin Stenella coeruleoalba from the Tyrrhenian coast of southern Italy. Post-mortem examination revealed liver congestion, splenic lymphoid depletion with capsular petechiae, and pneumonia. Histology revealed disseminated intravascular coagulation with vasculitis and congestion. Read More

Microorganisms 2019 May 24;7(5). Epub 2019 May 24.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Bacteria of the family are a type of Gram-negative microorganism typified by their obligate intracellular lifestyle. The majority of the members in the family are known pathogenic organisms that primarily infect the host mucosal surfaces in both humans and animals. For instance, is a well-known etiological agent for ocular and genital sexually transmitted diseases, while has been implicated in community-acquired pneumonia in humans. Read More

Acta Med Port 2019 Feb 28;32(2):161-164. Epub 2019 Feb 28.

Serviço de Doenças Infeciosas. Centro Hospitalar do Porto. Porto. Portugal.

Psittacosis is a rare disease caused by Chlamydophila psittaci, an intracellular bacteria transmitted by contaminated birds. The clinical and radiological presentations are nonspecific. We describe a case of a 42-year-old woman, with known exposure to birds, who presented to the emergency department with one-week evolution of myalgia, polyarthritis, and respiratory symptoms. Read More

Front Microbiol 2019 4;10:113. Epub 2019 Feb 4.

The Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD, Australia.

are a genus of successful obligate intracellular pathogens spread across humans, wildlife, and domesticated animals. The most common species reported in livestock in this genus are , , , and . Chlamydial infections trigger a series of inflammatory disease-related sequelae including arthritis, conjunctivitis, pneumonia, and abortion. Read More

Microb Pathog 2019 Apr 28;129:106-111. Epub 2019 Jan 28.

Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin, PR China. Electronic address:

Chlamydia is an obligate intracellular bacteria, which can infect cervix, urethra, conjunctiva, joints, lungs and so on. Neutrophils are important in host protection against microbial invasion during the early phase of infection. Here, to investigate the mechanism of IL-17A in recruiting neutrophils during Chlamydia muridarum (Cm) lung infection, we introduced IL-17A antibodies and IL-17 mice to confirm the effect of IL-17A on influencing neutrophil attractants expressions. Read More

Antimicrob Agents Chemother 2019 02 29;63(2). Epub 2019 Jan 29.

Department of Pediatrics, Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

The activities of omadacycline, azithromycin, doxycycline, moxifloxacin, and levofloxacin were tested against 15 isolates of The minimum inhibitory concentration at which 90% of the isolates of were inhibited by omadacycline was 0.25 μg/ml (range, 0.03 to 0. Read More

Lakartidningen 2018 11 27;115. Epub 2018 Nov 27.

Klinisk kemi och Klinisk och experimentell medicin, Linköpings Universitet - Linköping , Sweden -.

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract which caters for a high predictive value in patients with symptoms and signs of community-acquired atypical pneumonias, provided optimal patient selection. Knowledge and awareness of treatable rare diseases amongst healthcare personnel combined with conveniently available cost-effective diagnostic techniques is essential for improvements in the handling of rare diseases. Read More

Lakartidningen 2018 11 27;115. Epub 2018 Nov 27.

Clinical Microbiology - Karolinska Universitetssjukhuset Solna, Sweden Clinical Microbiology - Karolinska Universitetssjukhuset Solna, Sweden.

Psittacosis, parrot fever, is an infectious disease caused by Chlamydophila psittaci, a common pathogen among birds. The clinical course ranges from a mild flu-like illness to severe disease that requires intensive care in humans. We report three cases of severe pneumonia where C. Read More

mSphere 2018 10 10;3(5). Epub 2018 Oct 10.

Department of Infectious Diseases and Microbiology, University of Luebeck, Luebeck, Germany

We demonstrate the genetic transformation of using a plasmid shuttle vector system which generates stable transformants. The equine N16 isolate harbors the 7.5-kb plasmid pCpnE1. Read More

BMC Genomics 2018 Aug 2;19(1):575. Epub 2018 Aug 2.

Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Beutenbergstraße 11A, 07745, Jena, Germany.

Background: Members of the phylum Chlamydiae are obligate intracellular pathogens of humans and animals and have a serious impact on host health. They comprise several zoonotic species with varying disease outcomes and prevalence. To investigate differences in virulence, we focused on Chlamydia psittaci, C. Read More