578 results match your criteria Chlamydial Pneumonias

Reliable and Sensitive Nested PCR for the Detection of in Sputum.

Microorganisms 2021 Apr 27;9(5). Epub 2021 Apr 27.

Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 842 15 Bratislava, Slovakia.

Chlamydia are Gram-negative, intracellular pathogens colonizing epithelial mucosa. They cause primarily atypical pneumonia and have recently been associated with chronic diseases. Diagnostics relies almost exclusively on serological methods; PCR tests are used rarely because in patients with positive ELISA, it is nearly impossible to identify chlamydial DNA. Read More

View Article and Full-Text PDF

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.

BMC Infect Dis 2021 Mar 17;21(1):270. Epub 2021 Mar 17.

Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave., Box 49, Brooklyn, NY, 11203, USA.

Background: Neonatal ocular prophylaxis with silver nitrate does not prevent neonatal conjunctivitis due to Chlamydia trachomatis. The efficacy of antibiotic containing preparations for prevention of neonatal chlamydial conjunctivitis (NCC) has not been established.

Objective: To examine published literature to determine whether antibiotic containing preparation are efficacious for prevention of NCC and C. Read More

View Article and Full-Text PDF

infection in patients hospitalised for community-acquired pneumonia in Southern Jordan.

Indian J Med Microbiol 2020 Jul-Dec;38(3 & 4):338-343

Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman, Jordan.

Purpose: Chlamydia pneumoniae is associated with human respiratory diseases. Few reports examined the involvement of this bacterium in community-acquired pneumonia (CAP) in Jordan. This study investigates for the first time the role of C. Read More

View Article and Full-Text PDF
November 2020

Development of a Plasmid Shuttle Vector System for Genetic Manipulation of Chlamydia psittaci.

mSphere 2020 08 26;5(4). Epub 2020 Aug 26.

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.

The obligate intracellular bacterium is a known avian pathogen causing psittacosis in birds and is capable of zoonotic transmission. In human pulmonary infections, can cause pneumonia associated with significant mortality if inadequately diagnosed and treated. Although intracellular manipulates host cell organelles for its replication and survival, it has been difficult to demonstrate host-pathogen interactions in infection due to the lack of easy-to-handle genetic manipulation tools. Read More

View Article and Full-Text PDF

Co-infection of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae: a case series and review of the literature.

Infection 2020 Dec 28;48(6):871-877. Epub 2020 Jul 28.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Introduction: The novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co-infections with other respiratory pathogens, with viral co-infection being the most representative agents. Co-infection with Mycoplasma pneumoniae has been described both in adults and pediatrics whereas only two cases of Chlamydia pneumoniae have been reported in a large US study so far. Read More

View Article and Full-Text PDF
December 2020

Haemolacria: a case of pseudomembranous conjunctivitis in a neonate.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Adolescent and Child Health, Mater Dei Hospital, Msida, Malta.

We report an unusual case of an 11-day-old neonate presenting with haemolacria on a background of sticky conjunctival discharge. This was secondary to pseudomembranous conjunctivitis which responded well to systemic erythromycin. Early appropriate treatment is important to prevent progression of the ophthalmic infection, which could lead to blindness, and to prevent other manifestations of neonatal chlamydial infection, particularly pneumonia, which could be fatal. Read More

View Article and Full-Text PDF

NK cells modulate T cell responses via interaction with dendritic cells in Chlamydophila pneumoniae infection.

Cell Immunol 2020 07 16;353:104132. Epub 2020 May 16.

Departments of Immunology and Medical Microbiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada. Electronic address:

Protective immune response to chlamydial infection is largely dependent on cell-mediated immune responses with IFN-γ production. Recent studies have shown the critical role of NK cells in bridging innate and adaptive immune responses. In this study, we investigated the effect of NK cells on T cell responses during Chlamydophila pneumoniae (Cpn) lung infection. Read More

View Article and Full-Text PDF

Regeneration of Pulmonary Tissue in a Calf Model of Fibrinonecrotic Bronchopneumonia Induced by Experimental Infection with .

Int J Mol Sci 2020 Apr 17;21(8). Epub 2020 Apr 17.

Institute for Molecular Pathogenesis, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Naumburgerstr. 96a, 07743 Jena, Germany.

Pneumonia is a cause of high morbidity and mortality in humans. Animal models are indispensable to investigate the complex cellular interactions during lung injury and repair in vivo. The time sequence of lesion development and regeneration is described after endobronchial inoculation of calves with Calves were necropsied 2-37 days after inoculation (dpi). Read More

View Article and Full-Text PDF

Naked-Eye Enumeration of Single Based on Light Scattering of Gold Nanoparticle Probe.

ACS Sens 2020 04 1;5(4):1140-1148. Epub 2020 Apr 1.

College of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

is a spherical zoonotic pathogen with a diameter of ∼200 nm, which can lead to a wide range of acute and chronic diseases in human body. Early and reliable on-site detection of is the key step to control the spread of the pathogen. However, the lack of a current technology with advantages of rapidity, ultrasensitivity, and convenience limits the implementation of traditional techniques for on-site detection of . Read More

View Article and Full-Text PDF

Feed-borne exacerbates respiratory distress in chickens infected with by inducing haemorrhagic pneumonia.

Avian Pathol 2020 Jun 12;49(3):251-260. Epub 2020 Mar 12.

College of Life Science and Engineering, Foshan University, Foshan, People's Republic of China.

is an important zoonotic pathogen and its oral route of infection plays an important role in the transmission and persistence. strain, a common contaminant of animal feed and feedstuffs, can cause severe diarrhoea and malnutrition in poultry. In our previous study, a strain (Dawu C), isolated from the haemorrhagic lungs of infected chickens, was shown to harbour two virulence genes () and was able to induce haemorrhagic lesions in the lungs, as well as gizzard erosion and ulceration (GEU) syndrome in broilers. Read More

View Article and Full-Text PDF

Anti-chlamydial activities of cell-permeable hydrophobic dipeptide-containing derivatives.

J Infect Chemother 2019 Dec 20;25(12):987-994. Epub 2019 Jun 20.

Department of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan.

The obligate intracellular bacteria chlamydia is major human pathogen that causes millions of trachoma, sexually transmitted infections and pneumonia worldwide. We serendipitously found that both calpain inhibitors z-Val-Phe-CHO and z-Leu-Nle-CHO showed marked inhibitory activity against chlamydial growth in human epithelial HeLa cells, whereas other calpain inhibitors not. These peptidomimetic inhibitors consist of N-benzyloxycarbonyl group and hydrophobic dipeptide derivatives. Read More

View Article and Full-Text PDF
December 2019

Molecular detection of Chlamydia abortus in a stranded Mediterranean striped dolphin Stenella coeruleoalba.

Dis Aquat Organ 2019 Jan;132(3):203-208

Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, Italy.

This study reports gross, histopathological, and molecular features of a Chlamydia abortus infection in a stranded female striped dolphin Stenella coeruleoalba from the Tyrrhenian coast of southern Italy. Post-mortem examination revealed liver congestion, splenic lymphoid depletion with capsular petechiae, and pneumonia. Histology revealed disseminated intravascular coagulation with vasculitis and congestion. Read More

View Article and Full-Text PDF
January 2019

: Diseases in Primary Hosts and Zoonosis.

Microorganisms 2019 May 24;7(5). Epub 2019 May 24.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Bacteria of the family are a type of Gram-negative microorganism typified by their obligate intracellular lifestyle. The majority of the members in the family are known pathogenic organisms that primarily infect the host mucosal surfaces in both humans and animals. For instance, is a well-known etiological agent for ocular and genital sexually transmitted diseases, while has been implicated in community-acquired pneumonia in humans. Read More

View Article and Full-Text PDF

[Human Psittacosis: A Case Report].

Acta Med Port 2019 Feb 28;32(2):161-164. Epub 2019 Feb 28.

Serviço de Doenças Infeciosas. Centro Hospitalar do Porto. Porto. Portugal.

Psittacosis is a rare disease caused by Chlamydophila psittaci, an intracellular bacteria transmitted by contaminated birds. The clinical and radiological presentations are nonspecific. We describe a case of a 42-year-old woman, with known exposure to birds, who presented to the emergency department with one-week evolution of myalgia, polyarthritis, and respiratory symptoms. Read More

View Article and Full-Text PDF
February 2019

Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues.

Front Microbiol 2019 4;10:113. Epub 2019 Feb 4.

The Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD, Australia.

are a genus of successful obligate intracellular pathogens spread across humans, wildlife, and domesticated animals. The most common species reported in livestock in this genus are , , , and . Chlamydial infections trigger a series of inflammatory disease-related sequelae including arthritis, conjunctivitis, pneumonia, and abortion. Read More

View Article and Full-Text PDF
February 2019

Endogenous IL-17A mediated neutrophil infiltration by promoting chemokines expression during chlamydial lung infection.

Microb Pathog 2019 Apr 28;129:106-111. Epub 2019 Jan 28.

Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin, PR China. Electronic address:

Chlamydia is an obligate intracellular bacteria, which can infect cervix, urethra, conjunctiva, joints, lungs and so on. Neutrophils are important in host protection against microbial invasion during the early phase of infection. Here, to investigate the mechanism of IL-17A in recruiting neutrophils during Chlamydia muridarum (Cm) lung infection, we introduced IL-17A antibodies and IL-17 mice to confirm the effect of IL-17A on influencing neutrophil attractants expressions. Read More

View Article and Full-Text PDF

Activity of Omadacycline against .

Antimicrob Agents Chemother 2019 02 29;63(2). Epub 2019 Jan 29.

Department of Pediatrics, Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

The activities of omadacycline, azithromycin, doxycycline, moxifloxacin, and levofloxacin were tested against 15 isolates of The minimum inhibitory concentration at which 90% of the isolates of were inhibited by omadacycline was 0.25 μg/ml (range, 0.03 to 0. Read More

View Article and Full-Text PDF
February 2019

[Laboratory diagnosis of rare diseases].

Lakartidningen 2018 11 27;115. Epub 2018 Nov 27.

Klinisk kemi och Klinisk och experimentell medicin, Linköpings Universitet - Linköping , Sweden -.

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract which caters for a high predictive value in patients with symptoms and signs of community-acquired atypical pneumonias, provided optimal patient selection. Knowledge and awareness of treatable rare diseases amongst healthcare personnel combined with conveniently available cost-effective diagnostic techniques is essential for improvements in the handling of rare diseases. Read More

View Article and Full-Text PDF
November 2018

[Psittacosis - a forgotten diagnosis in Sweden?]

Lakartidningen 2018 11 27;115. Epub 2018 Nov 27.

Clinical Microbiology - Karolinska Universitetssjukhuset Solna, Sweden Clinical Microbiology - Karolinska Universitetssjukhuset Solna, Sweden.

Psittacosis, parrot fever, is an infectious disease caused by Chlamydophila psittaci, a common pathogen among birds. The clinical course ranges from a mild flu-like illness to severe disease that requires intensive care in humans. We report three cases of severe pneumonia where C. Read More

View Article and Full-Text PDF
November 2018

The Genetic Transformation of Chlamydia pneumoniae.

mSphere 2018 10 10;3(5). Epub 2018 Oct 10.

Department of Infectious Diseases and Microbiology, University of Luebeck, Luebeck, Germany

We demonstrate the genetic transformation of using a plasmid shuttle vector system which generates stable transformants. The equine N16 isolate harbors the 7.5-kb plasmid pCpnE1. Read More

View Article and Full-Text PDF
October 2018

Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles.

BMC Genomics 2018 Aug 2;19(1):575. Epub 2018 Aug 2.

Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Beutenbergstraße 11A, 07745, Jena, Germany.

Background: Members of the phylum Chlamydiae are obligate intracellular pathogens of humans and animals and have a serious impact on host health. They comprise several zoonotic species with varying disease outcomes and prevalence. To investigate differences in virulence, we focused on Chlamydia psittaci, C. Read More

View Article and Full-Text PDF

Inhibition of the Protein Phosphatase CppA Alters Development of Chlamydia trachomatis.

J Bacteriol 2018 10 10;200(19). Epub 2018 Sep 10.

Department of Microbiology, Southern Illinois University, Carbondale, Illinois, USA

Chlamydiae are obligate intracellular Gram-negative bacterial pathogens that undergo an essential, but poorly understood, biphasic developmental cycle transitioning between the infectious elementary body and the replicative reticulate body. Ser/Thr/Tyr phosphorylation has been increasingly recognized for its role in regulating bacterial physiology. spp. Read More

View Article and Full-Text PDF
October 2018

Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases.

Seidu A Richard

Curr Neurovasc Res 2018 ;15(3):262-273

Department of Surgery, Volta Regional Hospital, P.O. Box MA-374, Ho, Ghana, West Africa.

Chlamydia Pneumoniae (C. Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. Read More

View Article and Full-Text PDF

The p110δ isoforme of phosphatidylinositol 3-kinase plays an important role in host defense against chlamydial lung infection through influencing CD4+ T-cell function.

Pathog Dis 2018 08 1;76(6). Epub 2018 Aug 1.

Department of Immunology, Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba R3E0T5, Canada.

PI3Ks display integrant significance in T-cell development and differentiation, which is related to host defense against infections. Here, we investigated the role of p110δ isoform of PI3Ks in host defense against chlamydial lung infection in a mouse model. Our data showed that lung infection with Chlamydia muridarum (Cm) activated PI3K/AKT signaling pathway. Read More

View Article and Full-Text PDF

Influence of different delivery modes on the clinical characteristics of Chlamydia trachomatis pneumonia.

Eur J Pediatr 2018 Aug 31;177(8):1255-1260. Epub 2018 May 31.

Children's Hospital of Nanjing Medical University, Nanjing, China.

We analyzed the effects of delivery methods on Chlamydia trachomatis pneumonia in infants. Three hundred forty-four children hospitalized with Chlamydia trachomatis pneumonia were enrolled. They were divided into the vaginal delivery group and the cesarean delivery group. Read More

View Article and Full-Text PDF

Identification of Chlamydia pneumoniae candidate genes that interact with human apoptotic factor caspase-9.

J Gen Appl Microbiol 2018 Nov 15;64(5):253-257. Epub 2018 May 15.

Graduate School of Biology-Oriented Science and Technology, Kindai University.

Chlamydia pneumoniae is an obligate intracellular pathogen responsible for respiratory diseases, including pneumonia and bronchitis, and is highly involved in chronic diseases, including atherosclerosis, asthma, and Alzheimer's disease. We previously showed that the host apoptotic factor caspase-9 played a crucial role for chlamydial multiplication and host apoptosis inhibition by chlamydial infection. To identify chlamydial genes interacting with human caspase-9, yeast two-hybrid screening was performed and 5 chlamydial genes, including Cpj0838 and pmpG were isolated from the C. Read More

View Article and Full-Text PDF
November 2018

Clinical and histologic features of Mycoplasma pneumoniae-related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes.

J Am Acad Dermatol 2018 Jul 17;79(1):110-117. Epub 2018 Mar 17.

Dermatology Department, Assistance Publique Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Créteil, France; Epidémiologie en Dermatologie et Evaluation des Thérapeutiques, Université Paris-Est Créteil (UPEC) Val de Marne, Créteil, France; Referral Center for Toxic Bullous Diseases, AP-HP, Henri Mondor Hospital, Créteil, France; UPEC, Créteil, France.

Background: Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniae-related EM have been poorly described in the literature.

Objective: To highlight differences between M pneumoniae EM and non-M pneumoniae EM. Read More

View Article and Full-Text PDF

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.

Expert Rev Vaccines 2018 03 6;17(3):217-227. Epub 2018 Feb 6.

a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.

Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

View Article and Full-Text PDF