3,339 results match your criteria Chlamydial Genitourinary Infections


Men's Health: Scrotal and Testicular Conditions.

FP Essent 2021 Apr;503:23-27

University of Michigan Medical School Department of Family Medicine, 300 North Ingalls St NI4C06, Ann Arbor, Michigan 48109-5435.

Scrotal and testicular conditions include benign masses, infections, testicular torsion, and testicular cancer. Common palpable benign scrotal masses include spermatocele, varicocele, and hydrocele. Most patients with these masses require no treatment. Read More

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A pilot study to determine Neisseria gonorrhoeae-Chlamydia trachomatis coinfection rates in symptomatic patients attending STI Clinics, New Delhi, India.

Indian J Dermatol Venereol Leprol 2021 03 2:1-5. Epub 2021 Mar 2.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Neisseria gonorrhoeae and Chlamydia trachomatis are the two most prevalent bacterial sexually transmitted infections. For over two decades, treatment guidelines have recommended empirical co-treatment for N.gonorrhoeae and C. Read More

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Assessment for sexually transmitted infections in men who have sex with men attending a nurse-run HIV preexposure prophylaxis clinic.

J Am Assoc Nurse Pract 2021 Feb 18. Epub 2021 Feb 18.

HIV Clinical Nurse Specialist, Harrison, Ohio.

Background: Male-to-male sexual contact remains the primary mode of transmission for HIV and other sexually transmitted infections (STIs) in the United States. Reported STI rates in men who have sex with men (MSM) taking HIV preexposure prophylaxis (PrEP) are higher than expected, possibly due to decreased condom use while on PrEP or more frequent STI screening with routine PrEP care.

Local Problem: Hamilton County, located in southwestern Ohio, consistently has the highest rates of gonorrhea and syphilis and second highest rate of chlamydia in the state. Read More

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February 2021

Prevalence of urogenital, anal, and pharyngeal infections with Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium: a cross-sectional study in Reunion island.

BMC Infect Dis 2021 Jan 21;21(1):95. Epub 2021 Jan 21.

CHU Réunion, Service des Maladies Infectieuses - Dermatologie, Saint Pierre, La Réunion, France.

Background: Recommendations for sexually transmitted infection (STI) screening vary significantly across countries. This study evaluated the prevalence of urogenital and extragenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG) in patients visiting a French STI clinic in the Indian Ocean region to determine whether current STI screening practices should be updated.

Methods: This cross-sectional study examined all patients who visited the STI clinic between 2014 and 2015. Read More

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January 2021

Women Are Less Likely to Be Tested for HIV or Offered Preexposure Prophylaxis at the Time of Sexually Transmitted Infection Diagnosis.

Sex Transm Dis 2021 Jan;48(1):32-36

Department of Internal Medicine, Division of Infectious Diseases.

Background: Ending the HIV epidemic requires linkage of at-risk individuals from diverse health care settings to comprehensive HIV prevention services. Sexually transmitted infections (STIs) are significant biomarkers of HIV risk and should trigger preexposure prophylaxis (PrEP) discussion. We reviewed STI testing practices outside of sexual health clinics to identify opportunities for improvement in the provision of HIV prevention services. Read More

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January 2021

Performance of a single-use, rapid, point-of-care PCR device for the detection of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis: a cross-sectional study.

Lancet Infect Dis 2021 05 23;21(5):668-676. Epub 2020 Nov 23.

Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA.

Background: Timely detection and treatment are important for the control of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis. The objective of this study was to measure the performance of the Visby Medical Sexual Health Test, a single-use, point-of-care PCR device.

Methods: Women aged 14 years and older who presented consecutively to ten clinical sites across seven US states were enrolled for a cross-sectional, single-visit study. Read More

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Towards a chlamydia vaccine.

Authors:
Grant Otto

Nat Rev Microbiol 2021 01;19(1)

Nature Reviews Microbiology, .

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January 2021

Rapid multiplex PCR assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis in genitourinary samples: A 30-minute assay.

J Microbiol Methods 2021 01 12;180:106103. Epub 2020 Nov 12.

Department of Urology, Nara Medical University, Nara, Japan.

We developed a rapid multiplex PCR assay available in bedside for the simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis, which enables diagnosis in less than 30 minutes. In this study, we validated the clinical utility of this assay including its sensitivity and specificity for NG and CT detection. Read More

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January 2021

[The efficiency of combination therapy of non-gonococcal urethritis in men].

Urologiia 2020 11(5):5-9

Department of Physics and Informatics of Altai State Medical University of the Ministry of Health of Russia, Barnaul, Russia.

Aim: To carry out a comparative assessment of the efficiency of combination therapy for non-gonococcal urethritis (NGU) in men.

Materials And Methods: a total of 124 patients with NGU and laboratory-confirmed urogenital infection were included in the study. The diagnostic methods included microscopy of urethral smear, real-time polymerase chain reaction (PCR) for the detection of uropathogens and laser Doppler flowmetry for evaluating the urethral microcirculation. Read More

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November 2020

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens.

Front Immunol 2020 30;11:2115. Epub 2020 Sep 30.

Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The epididymis is an important male accessory sex organ where sperm motility and fertilization ability develop. When spermatozoa carrying foreign antigens enter the epididymis, the epididymis shows "immune privilege" to tolerate them. It is well-known that a tolerogenic environment exists in the caput epididymis, while pro-inflammatory circumstances prefer the cauda epididymis. Read More

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IL-1α Is Essential for Oviduct Pathology during Genital Chlamydial Infection in Mice.

J Immunol 2020 12 21;205(11):3037-3049. Epub 2020 Oct 21.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

infection of the female genital tract can lead to irreversible fallopian tube scarring. In the mouse model of genital infection using IL-1R signaling plays a critical role in oviduct tissue damage. In this study, we investigated the pathologic role of IL-1α, one of the two proinflammatory cytokines that bind to IL-1R. Read More

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December 2020

Infection, when Treated during Pregnancy, Is Not Associated with Preterm Birth in an Urban Safety-Net Hospital.

Infect Dis Obstet Gynecol 2020 5;2020:8890619. Epub 2020 Oct 5.

Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA, USA.

Preterm birth is a major public health problem, occurring in more than half a million births per year in the United States. A number of maternal conditions have been recognized as risk factors for preterm birth, but for the majority of cases, the etiology is not completely understood. is one of the most prevalent sexually transmitted infections in the world. Read More

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October 2020

All-in-one microfluidic nucleic acid diagnosis system for multiplex detection of sexually transmitted pathogens directly from genitourinary secretions.

Talanta 2021 Jan 3;221:121462. Epub 2020 Aug 3.

Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, PR China. Electronic address:

Sexually transmitted infections are a serious public health concern worldwide, especially in young people. More than 30 pathogens can cause sexually transmitted diseases and co-infection often occurs. Therefore, the development of fast, low-cost and easy-to-use diagnostic screening methods is urgently needed for disease prevention and control. Read More

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January 2021

Hormonal contraception and risk of STIs and bacterial vaginosis in South African adolescents: secondary analysis of a randomised trial.

Sex Transm Infect 2021 03 28;97(2):112-117. Epub 2020 Sep 28.

Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, South Africa

Objectives: Young women in sub-Saharan Africa are at high risk of STIs and unintended pregnancies, yet hormonal contraceptive (HC) use may affect STI risk. We compared the influence of three HCs on the incidence and prevalence of STIs and bacterial vaginosis (BV) in South African adolescents.

Methods: One hundred and thirty adolescents between 15 and 19 years were randomised to the injectable norethisterone enanthate (Net-En), combined oral contraceptives (COC) (Triphasil or Nordette) or a combined contraceptive vaginal ring (CCVR; NuvaRing) for 16 weeks (clinicaltrials. Read More

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Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach.

Sci Rep 2020 09 15;10(1):15131. Epub 2020 Sep 15.

Fortis Hospital, B-22, Sector 62, Gautam Buddh Nagar, Noida, Uttar Pradesh, 201301, India.

Reactive Arthritis (ReA), a rare seronegative inflammatory arthritis, lacks exquisite classification under rheumatic autoimmunity. ReA is solely established using differential clinical diagnosis of the patient cohorts, where pathogenic triggers linked to enteric and urogenital microorganisms e.g. Read More

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September 2020

Application of leukocyte subsets and sperm DNA fragment rate in infertile men with asymptomatic infection of genital tract.

Ann Palliat Med 2021 Feb 9;10(2):1021. Epub 2020 Sep 9.

Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.

Background: About 15% of male infertility is due to genital tract infection and inflammation, some of them have no clinical symptoms, but manifested as leukocytospermia (LCS). Leukopenia will lead to functional impairment of male sperm and integrity damage of sperm morphology. A large amount of reactive oxygen species (ROS) produced by leukocytes can damage sperm nuclear DNA. Read More

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February 2021

[Evaluation of the influence of systemic enzyme therapy on immune reactions in genitourinary chlamydia infection].

Urologiia 2020 Sep(4):36-44

Novosibirsk State Medical University of the Ministry of Health of Russian Federation, Novosibirsk, Russia.

Purpose: Assessment of the severity of immunological disorders in patients with hlamydia trachomatis (CT) infection and the effectiveness of antibacterial therapy in combination with systemic enzyme therapy for the eradication of pathogenic pathogen and correction of detected violations of the immune system.

Materials And Methods: 84 patients with identified CT infection were divided into 2 clinical groups: group 1 (42 people) received antibiotic therapy with doxycycline monohydrate for 10 days, 100 mg 2 times a day (the first dose of 200 mg) at regular intervals (daily dose of 200 mg, course - 2.0 g. Read More

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September 2020

Oropharyngeal in women; spontaneous clearance and cure after treatment (FemCure).

Sex Transm Infect 2021 03 31;97(2):147-151. Epub 2020 Jul 31.

Department of Sexual Health, Infectious Diseases, and Environmental Health, Public Health Service South Limburg, Heerlen, Limburg, The Netherlands.

Objectives: Women attending STI clinics are not routinely tested for oropharyngeal (CT) infections. We aimed to assess spontaneous clearance of oropharyngeal CT and cure after antibiotic treatment in women.

Methods: Women with vaginal or rectal CT (n=560) were recruited at STI clinics in 2016-2017, as part of the FemCure study (prospective cohort study). Read More

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Spontaneous clearance of genital and extragenital : data from GToG.

Sex Transm Infect 2020 12 30;96(8):556-561. Epub 2020 Jul 30.

Department of Sexual Health and HIV, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Objectives: (NG) infection can resolve without antibiotic treatment, however the literature describing the frequency of clearance at individual sites, how rapidly it occurs and potential predictive factors is limited. In this analysis of a subpopulation identified from a large multicentre UK cohort, we describe the overall rate of spontaneous clearance of infection and explore factors associated with this.

Methods: Data from the Gentamicin compared with Ceftriaxone for the Treatment of Gonorrhoea randomised controlled trial consisting of 720 patients with NG were analysed. Read More

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December 2020

Cervical Cytology of Samples with , , , , , and Detected by Multiplex PCR.

Biomed Res Int 2020 7;2020:7045217. Epub 2020 Jul 7.

Pathology Department of Brasília University, Brasília, Federal District, Brazil.

Introduction: Despite increasing application of molecular diagnostic methods for the detection of sexually transmitted infections, the cytological findings in pap smears of patients with pathogens that can be identified only by PCR are not yet well described. The aim of this study was to describe the most common cytological features in cervical pap smears of patients with , , , , , , and detected by multiplex PCR.

Methods: Cervical samples for conventional and liquid-based cytology and for multiplex PCR were collected from women ranging from 23 to 54 years old, who underwent routine screening at a gynecological Unit. Read More

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Changes in the vaginal microbiota following antibiotic treatment for Mycoplasma genitalium, Chlamydia trachomatis and bacterial vaginosis.

PLoS One 2020 28;15(7):e0236036. Epub 2020 Jul 28.

Department of Dermatovenereology, Linköping University Hospital, Linköping, Sweden.

The human vagina harbor a rich microbiota. The optimal state is dominated by lactobacilli that help to maintain health and prevent various diseases. However, the microbiota may rapidly change to a polymicrobial state that has been linked to a number of diseases. Read More

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September 2020

Endocervical miRNA Expression Profiles in Women Positive for Chlamydia trachomatis with Clinical Signs and/or Symptoms Are Distinct from Those in Women Positive for Chlamydia trachomatis without Signs and Symptoms.

Infect Immun 2020 09 18;88(10). Epub 2020 Sep 18.

Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA

is the leading cause of sexually transmitted infections that may progress to pelvic inflammatory disease and infertility. No effective vaccine exists for , nor are there biomarkers available that readily predict disease progression. In this cross-sectional pilot study, we recruited symptomatic and asymptomatic women with (CT) infection and asymptomatic, uninfected control women from an urban sexually transmitted disease clinic to determine if there were differences in microRNA (miRNA) expression. Read More

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September 2020

elicits TLR3 expression but disrupts the inflammatory signaling down-modulating NFκB and IRF3 transcription factors in human Sertoli cells.

J Biol Regul Homeost Agents 2020 May-Jun;34(3):977-986

Department of Public Health and Infectious Diseases, Section of Microbiology, University of Rome "Sapienza", Rome, Italy.

, the leading cause of bacterial sexually transmitted diseases worldwide, can disseminate and localize to the upper genital tract impairing reproductive function. Specifically, ascending genital infection has been demonstrated to cause epididymitis or epididymo-orchitis, well-known risk factors for male infertility. possesses the ability to infect primary human Sertoli cells, key elements for the spermatogenetic process and the immune protection of germ cells. Read More

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September 2020

Genital and extra-genital Chlamydia trachomatis and Neisseria gonorrhoeae infections in young women attending a Sexually Transmitted Infections (STI) clinic.

New Microbiol 2020 Jul 13;43(3):115-120. Epub 2020 Jun 13.

Dermatology, DIMES, University of Bologna, via Massarenti 9, Bologna, Italy.

Chlamydia trachomatis and Neisseria gonorrhoeae are the most common agents of bacterial sexually transmitted infections (STIs) worldwide. Here, we evaluated genital and extra-genital C. trachomatis and N. Read More

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New Approach to Microscopy of Gram-Stained Urethral Smear: The Kissing Slide Method.

Sex Transm Dis 2020 Oct;47(10):712-715

Department of Clinical Microbiology and Infectious Disease, Training and Research Hospital, Antalya, Turkey.

Background: The effectiveness of microscopy of Gram-stained smear (GSS) for the detection of male urethral infection is debatable, especially in cases with low inflammation and no visible urethral discharge. This clinical study compared GSS samples collected with the conventional swab method and our new technique, the kissing slide method, together with polymerase chain reaction results to demonstrate the effectiveness of this new method in men with acute urethritis.

Methods: The study included 64 men who presented to the urology outpatient clinic with complaints of acute urethritis between October 2019 and January 2020. Read More

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October 2020

Increasing Vaginal Testing in Adolescent and Young Adults.

Pediatrics 2020 08 7;146(2). Epub 2020 Jul 7.

Quality and Safety,

Objective: The Centers for Disease Control and Prevention recommend testing for in sexually active female patients <25 years old using nucleic-acid amplification tests (NAAT) from a vaginal swab. Our providers were typically testing using the less sensitive urine NAATs. We aimed to increase the percentage of urogenital NAATs performed by using vaginal swabs in adolescent female patients ages 10 through 20 years from 1. Read More

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Human Fallopian Tube Epithelial Cell Culture Model To Study Host Responses to Chlamydia trachomatis Infection.

Infect Immun 2020 08 19;88(9). Epub 2020 Aug 19.

Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA

infection of the human fallopian tubes can lead to damaging inflammation and scarring, ultimately resulting in infertility. To study the human cellular responses to chlamydial infection, researchers have frequently used transformed cell lines that can have limited translational relevance. We developed a primary human fallopian tube epithelial cell model based on a method previously established for culture of primary human bronchial epithelial cells. Read More

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Men and Women Repeatedly Infected With Chlamydia trachomatis Have a Lower Urogenital Bacterial Load.

Sex Transm Dis 2020 11;47(11):e51-e53

Department of Medical Microbiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center (MUMC+), AZ Maastricht.

We assessed whether patients repeatedly infected with Chlamydia trachomatis (CT) have a lower urogenital or anorectal CT load. A CT-positive retest was independently associated with higher vaginal and higher urine Cq values (P<0.01). Read More

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November 2020

Communication Strategies Used to Obtain Clinical Histories Before Remotely Prescribing Antibiotics for Postal Treatment of Uncomplicated Genital Chlamydia: Service Evaluation.

J Med Internet Res 2020 06 17;22(6):e15970. Epub 2020 Jun 17.

School of Population Health & Environmental Sciences, King's College London, London, United Kingdom.

Background: Web-based services for testing of sexually transmitted infections are widely available across the United Kingdom. Remote prescriptions with medications posted home may support prompt treatment; however, the absence of face-to-face contact with clinicians raises clinical safety issues as medical history may not be accurately provided.

Objective: This service evaluation aimed to capture the use and explore the safety of 3 remote communication strategies employed within a web-based service offering remote prescriptions of antibiotics, delivered via post, for uncomplicated genital Chlamydia trachomatis. Read More

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