3,244 results match your criteria Chlamydial Genitourinary Infections


Regional differences in chlamydia and gonorrhoeae positivity rate among heterosexual STI clinic visitors in the Netherlands: contribution of client and regional characteristics as assessed by cross-sectional surveillance data.

BMJ Open 2019 Jan 21;9(1):e022793. Epub 2019 Jan 21.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Rotterdam, The Netherlands.

Objectives: To assess to what extent triage criteria, client and regional characteristics explain regional differences in (Ct) and (Ng) positivity in sexually transmitted infection (STI) clinics.

Design: Retrospective cross-sectional study on the Dutch STI surveillance database of all 24 STI clinics.

Participants: STI clinic visits of heterosexual persons in 2015 with a Ct (n=101 495) and/or Ng test (n=101 081). Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02279
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http://dx.doi.org/10.1136/bmjopen-2018-022793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347934PMC
January 2019
3 Reads

The role of infections in multiple sclerosis.

Mult Scler 2019 Jan 14:1352458518823940. Epub 2019 Jan 14.

Department of Neurology, FLENI, Buenos Aires, Argentina; Center for Research on Neuroimmunological Diseases, FLENI, Buenos Aires, Argentina.

Several lines of evidence suggest that multiple sclerosis (MS), like other autoimmune diseases, may be triggered by microbial infections. Pathogens associated with development or exacerbation of MS include bacteria, such as Chlamydia pneumoniae, Staphylococcus aureus-produced enterotoxins that function as superantigens, and viruses of the Herpesviridae (Epstein-Barr virus and human herpes virus 6) and human endogenous retrovirus families. However, to date, no single pathogen has been accepted as causal agent. Read More

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http://dx.doi.org/10.1177/1352458518823940DOI Listing
January 2019
2 Reads

Comparison of an in-house real-time duplex PCR assay with commercial HOLOGIC® APTIMA assays for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis in urine and extra-genital specimens.

BMC Infect Dis 2019 Jan 3;19(1). Epub 2019 Jan 3.

Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases (NICD), National Health Laboratory Service (NHLS), Johannesburg, South Africa.

Background: Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are mostly asymptomatic, and important reservoir sites of infection as they often go undetected and may be more difficult to eradicate with recommended therapeutic regimens. Commercial nucleic acid amplification tests (NAATs) have not received regulatory approval for the detection of N. gonorrhoeae and C. Read More

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http://dx.doi.org/10.1186/s12879-018-3629-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318993PMC
January 2019
2 Reads

Optimising the short and long-term clinical outcomes for koalas (Phascolarctos cinereus) during treatment for chlamydial infection and disease.

PLoS One 2018 27;13(12):e0209679. Epub 2018 Dec 27.

Endeavour Veterinary Ecology Pty Ltd, Toorbul, Queensland, Australia.

Koalas (Phascolarctos cinereus) have suffered severe declines in the northern extent of their range due to a variety of threats, including habitat destruction, trauma from cars and dogs, climate change and importantly, disease. The most significant pathogen in koalas is Chlamydia pecorum, which causes inflammation and fibrosis at mucosal sites, resulting in blindness, infertility and death in severe cases. Chlamydia treatment can be problematic in koalas as the response to treatment is often poor in chronic cases and antimicrobial choice is limited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209679PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307739PMC
December 2018
22 Reads

Gonorrhea and chlamydia prevalence in different anatomical sites among men who have sex with men: a cross-sectional study in Guangzhou, China.

BMC Infect Dis 2018 Dec 18;18(1):675. Epub 2018 Dec 18.

Department of Sexually Transmitted Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Background: A high rectal and oropharyngeal sexually transmitted infection (STI) burden has been reported among men who have sex with men (MSM) in many regions, but little data exists on rectal and oropharyngeal STIs among MSM in China. The purpose of this study was to determine the prevalence of gonorrhea and chlamydia at different anatomic sites among MSM in Guangzhou, China.

Methods: We recruited a cross-sectional sample of MSM in one Chinese city and collected detailed information about socio-demographic characteristics and sexual behaviors. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3579-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299533PMC
December 2018
9 Reads

Genetic Inactivation of Inclusion Membrane Protein CT228 Alters MYPT1 Recruitment, Extrusion Production, and Longevity of Infection.

Front Cell Infect Microbiol 2018 30;8:415. Epub 2018 Nov 30.

Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, United States.

is an obligate intracellular pathogen with global health and economic impact. Upon infection, resides within a protective niche, the inclusion, wherein it replicates and usurps host cell machinery and resources. The inclusion membrane is the key host-pathogen interface that governs specific protein-protein interactions to manipulate host signaling pathways. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284022PMC
November 2018
2 Reads

Risk of Chlamydia abortus transmission via embryo transfer using in vitro produced early bovine embryos.

Theriogenology 2019 Mar 1;126:114-120. Epub 2018 Dec 1.

LUNAM University, Oniris, Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Sanitary Security of Reproduction Biotechnology Unit, Nantes, France. Electronic address:

The objectives of this study were to determine (i) whether Chlamydia (C.) abortus would adhere to the intact zona pellucida (ZP-intact) of early in vitro produced bovine embryos; (ii) whether the bacteria would adhere to the embryos (ZP-free) after in vitro infection; and (iii) the efficacy of the International Embryo Transfer Society (IETS) washing protocol. The experimentation was made twice. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2018.11.033DOI Listing
March 2019
2 Reads

Comparison of rRNA-based and DNA-based nucleic acid amplifications for detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Ureaplasma urealyticum in urogenital swabs.

BMC Infect Dis 2018 Dec 12;18(1):651. Epub 2018 Dec 12.

Department of Infection Control, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, People's Republic of China.

Background: Nucleic acid amplification tests (NAAT) are well-accepted in diagnosis and surveillance of sexually infectious pathogens worldwide. However, performance differences between a RNA-based NAAT and DNA-based NAAT are rarely reported. This study compares the performances of the RNA-based SAT (simultaneous amplification and testing) assay and the DNA-based quantitative real-time polymerase chain reaction (qPCR) assay. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3580-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291997PMC
December 2018
9 Reads

Cervico-vaginal secretion cytokine profile: A non-invasive approach to study the endometrial receptivity in IVF cycles.

Am J Reprod Immunol 2019 Jan 26;81(1):e13064. Epub 2018 Nov 26.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Problem: Cytokines have a significant role in the process of embryo implantation, trophoblast growth, and differentiation by modulating the immune and endocrine system. The aim of this study was to investigate the profile of a large set of cytokines in the cervico-vaginal washing of women undergoing IVF, to explore the association of these proteins with a good receptive endometrium.

Method Of Study: A cohort of 155 women scheduled for IVF cycle was recruited. Read More

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http://doi.wiley.com/10.1111/aji.13064
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http://dx.doi.org/10.1111/aji.13064DOI Listing
January 2019
14 Reads
2.438 Impact Factor

WHO laboratory validation of Xpert CT/NG and Xpert TV on the GeneXpert system verifies high performances.

APMIS 2018 Dec;126(12):907-912

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Effective tests for diagnosis of sexually transmitted infections (STIs), used point of care to inform treatment and management decisions, are urgently needed. We evaluated the analytical sensitivity and specificity of the Xpert CT/NG and Xpert TV tests, examining 339 samples spiked with phenotypically and/or genetically diverse strains of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis, and other related species that may cross-react. The APTIMA Combo 2 test and APTIMA TV test were used as reference tests. Read More

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http://doi.wiley.com/10.1111/apm.12902
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http://dx.doi.org/10.1111/apm.12902DOI Listing
December 2018
7 Reads

Schistosoma mansoni infection and socio-behavioural predictors of HIV risk: a cross-sectional study in women from Uganda.

BMC Infect Dis 2018 Nov 19;18(1):586. Epub 2018 Nov 19.

Department of Immunology, University of Toronto, Toronto, Canada.

Background: Schistosoma mansoni infection has been associated with increased risk of HIV transmission in African women. This association might be causal or mediated through shared socio-behavioural factors and associated co-infections. We tested the latter hypothesis in a cross-sectional pilot study in a cohort of women from a S. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3481-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245923PMC
November 2018
8 Reads

Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: a nested case-control study.

BMC Infect Dis 2018 Nov 6;18(1):549. Epub 2018 Nov 6.

Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan, 185, Ghent, Belgium.

Background: Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated with adverse pregnancy outcomes.

Methods: In a nested case-control study, vaginal swabs from 79 pregnant women, i. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3455-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219184PMC
November 2018
19 Reads

'Test n Treat' (TnT): a cluster randomized feasibility trial of on-site rapid Chlamydia trachomatis tests and treatment in ethnically diverse, sexually active teenagers attending technical colleges.

Clin Microbiol Infect 2018 Nov 1. Epub 2018 Nov 1.

School of Population Health and Environmental Sciences, King's College London, London, UK.

Objectives: We conducted a cluster-randomized feasibility trial of 90-minute Chlamydia trachomatis tests and same day on-site treatment ('Test n Treat/TnT') in six technical colleges in London, England, to assess TnT uptake rates; follow-up rates; prevalence of C. trachomatis at baseline and 7 months; time to treatment; acceptability of TnT.

Methods: Participants completed questionnaires and provided genitourinary samples at baseline and 7 months. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.10.019DOI Listing
November 2018
2 Reads

Abortion storm induced by the live C. abortus vaccine 1B strain in a vaccinated sheep flock, mimicking a natural wild-type infection.

Vet Microbiol 2018 Nov 18;225:31-33. Epub 2018 Sep 18.

Cavac, La Roche sur Yon, France.

Chlamydia abortus is responsible for enzootic abortion (known as ovine enzootic abortion (OEA) and enzootic abortion of ewes (EAE)) in both sheep and goats and has major economic implications for the farming industry worldwide. A virulence-attenuated mutant strain of C. abortus (strain 1B) is currently commercially available as a live attenuated vaccine for immunization of sheep and goats in several European countries. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.09.012DOI Listing
November 2018
3 Reads

A rare case of large pyosalpinx in an elderly patient with well-controlled type 2 diabetes mellitus: a case report.

J Med Case Rep 2018 Oct 6;12(1):286. Epub 2018 Oct 6.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

Background: Pyosalpinx, which is one of the pelvic inflammatory diseases, is usually observed in young women; it is rarely found in older women. Possible causative agents are thought to be Chlamydia trachomatis and Neisseria gonorrhea in addition to some Enterobacteriaceae. On the other hand, type 2 diabetes is a disease with a lot of complications such as hyperglycemia, inflammation, and immune disorders. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1841-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173840PMC
October 2018
14 Reads

Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections among pregnant women and eye colonization of their neonates at birth time, Shiraz, Southern Iran.

BMC Infect Dis 2018 Sep 24;18(1):477. Epub 2018 Sep 24.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Chlamydia trachomatis and Neisseria gonorrhoeae are the two common transmissible pathogens from pregnant women to their neonates. Given the lack of routine screening and treatment of pregnant women in some areas, the possibility of transmission rises. This study seeks to determine the prevalence of C. Read More

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http://dx.doi.org/10.1186/s12879-018-3382-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154405PMC
September 2018
2 Reads

Do healthcare professionals and young adults know about the National Chlamydia Screening Programme? Findings from two cross-sectional surveys.

Int J STD AIDS 2018 Sep 19:956462418797849. Epub 2018 Sep 19.

2 HIV & STI Department, Public Health England, London, UK.

The extent to which healthcare professionals (HCPs) and young people (YP) are aware of, and adhere to, National Chlamydia Screening Programme (NCSP) recommendations on testing frequency is unclear. To address this two cross-sectional surveys in 2015-2016: one among genitourinary medicine (GUM) and non-GUM HCPs (n = 109) and the other among YP attending a GUM clinic in England (n = 195). For both, questions were designed to measure awareness of NCSP guidance and whether respondents acted on that knowledge. Read More

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http://journals.sagepub.com/doi/10.1177/0956462418797849
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http://dx.doi.org/10.1177/0956462418797849DOI Listing
September 2018
6 Reads

Prevalence of Sexually Transmitted Infections among Married Women in Rural Nepal.

Infect Dis Obstet Gynecol 2018 26;2018:4980396. Epub 2018 Aug 26.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Introduction: We have previously determined the prevalence of human papillomavirus (HPV) infection among women in rural Nepal. In the current study, we also wanted to examine the prevalence of and risk factors for other sexually transmitted infections (STIs) in the same population.

Methods: Population-based study of nonpregnant women ≥ 15 years who were married or had a history of marriage in the past, residing in five rural villages in Nepal. Read More

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https://www.hindawi.com/journals/idog/2018/4980396/
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http://dx.doi.org/10.1155/2018/4980396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129351PMC
January 2019
15 Reads

Modelling-based evaluation of the costs, benefits and cost-effectiveness of multipathogen point-of-care tests for sexually transmitted infections in symptomatic genitourinary medicine clinic attendees.

BMJ Open 2018 Sep 10;8(9):e020394. Epub 2018 Sep 10.

HIV/STI Department, National Infection Service, Public Health England, 61 Colindale Avenue, London, UK.

Objectives: To quantify the costs, benefits and cost-effectiveness of three multipathogen point-of-care (POC) testing strategies for detecting common sexually transmitted infections (STIs) compared with standard laboratory testing.

Design: Modelling study.

Setting: Genitourinary medicine (GUM) services in England. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-020394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144481PMC
September 2018
11 Reads
2.063 Impact Factor

A microbial game of whack-a-mole: clinical case series of the urethral uncloaking phenomenon caused by Corynebacterium glucuronolyticum in men treated for Chlamydia trachomatis urethritis.

Infection 2019 Feb 30;47(1):121-124. Epub 2018 Aug 30.

Clinical Microbiology and Parasitology Unit, Polyclinic "Dr. Zora Profozić", Bosutska 19, Zagreb, 10 000, Croatia.

Corynebacterium glucuronolyticum is a rare and neglected, but increasingly recognized bacterial agent of infectious urethritis and other genitourinary syndromes in men. This is the first description of its proclivity to resurface as a cause of sustained urethritis in male patients previously treated for Chlamydia trachomatis, which represents a phenomenon that has to be differentiated from a simple post-treatment overgrowth of a colonizing agent. Read More

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http://link.springer.com/10.1007/s15010-018-1211-8
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http://dx.doi.org/10.1007/s15010-018-1211-8DOI Listing
February 2019
6 Reads

The Role of Polymorphonuclear Leukocyte Counts from Urethra, Cervix, and Vaginal Wet Mount in Diagnosis of Nongonococcal Lower Genital Tract Infection.

Infect Dis Obstet Gynecol 2018 26;2018:8236575. Epub 2018 Jul 26.

Oslo University Hospital, Department of Venereology, The Olafia Clinic, Norwegian National Advisory Unit on Sexually Transmitted Infections, Oslo, Norway.

Objective: The aim of this study was to evaluate whether the polymorphonuclear leukocyte (PMNL) inflammatory response in women with nongonococcal lower genital tract infection (LGTI) can be used to optimize criteria for syndromic treatment.

Methods: A cross-sectional study of 375 women attending the STI clinic in Oslo. Urethral, cervical, and vaginal specimens underwent microscopy for PMNLs. Read More

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http://dx.doi.org/10.1155/2018/8236575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083538PMC
January 2019
7 Reads

Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up.

Prostate 2018 Sep 30;78(13):1024-1034. Epub 2018 May 30.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Background: To extend our previous observation of a short-term rise in prostate-specific antigen (PSA) concentration, a marker of prostate inflammation and cell damage, during and immediately following sexually transmitted and systemic infections, we examined the longer-term influence of these infections, both individually and cumulatively, on PSA over a mean of 10 years of follow-up in young active duty U.S. servicemen. Read More

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http://doi.wiley.com/10.1002/pros.23660
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http://dx.doi.org/10.1002/pros.23660DOI Listing
September 2018
10 Reads

Impact of bacterial traces belonging to the Enterobacteriaceae on the prevalence of Chlamydia trachomatis in women visiting a community hospital in Japan.

J Infect Chemother 2018 Oct 3;24(10):815-821. Epub 2018 Aug 3.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Nishi-5 Kita-12 Jo, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan. Electronic address:

We explored the bacteria present in the vaginal microbiota facilitating the prevalence of Chlamydia trachomatis in women visiting a community hospital in Sapporo, Japan, by amplicon sequencing. A total of 273 cervical swab samples were collected, and bacterial vaginosis was evaluated in all specimens by assessment of the Nugent score. In 16 of the samples, bacterial 16S rDNA could not be detected and they were therefore omitted from subsequent experiments (n = 257). Read More

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http://dx.doi.org/10.1016/j.jiac.2018.06.011DOI Listing
October 2018
3 Reads

[Primary study on the relationship between high-risk HPV infection and vaginal cervical microbiota].

Zhonghua Fu Chan Ke Za Zhi 2018 Jul;53(7):471-480

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

To understand characteristics of vaginal cervical microbiota in high-risk HPV (hrHPV) infected women and to uncover the relationship between hrHPV infection and vaginal cervical microbiota. All participants were randomly selected from Peking University First Hospital from September to October of 2017, including 5 subjects of control group, 5 cases of HPV16/18 group, 5 cases of other hrHPV infected group and 3 cases of cervical squamous carcinoma group. All subjects were required to fill in a questionnaire, and cervical and vaginal discharges were separately collected for microscopic examination and new generation sequencing targeting the variable region (V3-V4) of bacterial 16S rRNA gene. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.07.006DOI Listing
July 2018
18 Reads

The bacterial microbiota in first-void urine from men with and without idiopathic urethritis.

PLoS One 2018 27;13(7):e0201380. Epub 2018 Jul 27.

Department of Bacteriology, Parasitology and Mycology, Research Unit for Reproductive Tract Microbiology, Statens Serum Institut, Copenhagen, Denmark.

Background: Non-gonococcal urethritis (NGU) is a common syndrome in men. NGU may have several causes, but many cases are caused by sexually transmitted infections that may also cause complications in their female partners. Chlamydia trachomatis and Mycoplasma genitalium are the most common causes of NGU, but in up to 35% of the cases, none of the known viral or bacterial causes are found. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201380PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063444PMC
January 2019
5 Reads

2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge.

Int J STD AIDS 2018 Nov 27;29(13):1258-1272. Epub 2018 Jul 27.

5 Research Unit for Reproductive Microbiology, Statens Serum Institut, Copenhagen, Denmark.

Four common pathological conditions are associated with vaginal discharge: bacterial vaginosis, aerobic vaginitis, candidosis, and the sexually transmitted infection, trichomoniasis. Chlamydial or gonococcal cervical infection may result in vaginal discharge. Vaginal discharge may be caused by a range of other physiological and pathological conditions including atrophic vaginitis, desquamative inflammatory vaginitis, cervicitis, and mucoid ectopy. Read More

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http://dx.doi.org/10.1177/0956462418785451DOI Listing
November 2018
34 Reads

Health-related quality of life and psychosocial impacts of a diagnosis of non-specific genital infection in symptomatic heterosexual men attending UK sexual health clinics: a feasibility study.

BMJ Open 2018 Jun 30;8(6):e018213. Epub 2018 Jun 30.

St Georges University Hospitals NHS Foundation Trust, London, UK.

Introduction: Non-specific genital infection (NSGI; non-, non--associated urethritis) is a common diagnosis in symptomatic heterosexual men attending UK sexual health clinics (SHCs). but little is known about the psychosocial impact of this diagnosis.

Methods: We conducted an observational study among symptomatic heterosexual men attending SHCs to evaluate the psychosocial impact of an NSGI diagnosis compared with a diagnosis of (CT), or no abnormalities detected focusing on the feasibility of our study methodology. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-018213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042625PMC
June 2018
8 Reads
2.063 Impact Factor

The association between sexually transmitted infections, human papillomavirus, and cervical cytology abnormalities among women in Greece.

Int J Infect Dis 2018 Aug 11;73:72-77. Epub 2018 Jun 11.

Fourth Department of Internal Medicine, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Electronic address:

Objective: To investigate the diagnosis of sexually transmitted infections (STIs) with human papillomavirus (HPV) infection and the presence of cytological changes in the cervix in a cohort of sexually active women in Greece.

Methods: Cervical cytology testing and the molecular typing of HPV and other STIs were performed for 345 sexually active women aged between 18 and 45 years (mean 33.2±7. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.06.001DOI Listing
August 2018
10 Reads

'Test n Treat (TnT)'- Rapid testing and same-day, on-site treatment to reduce rates of chlamydia in sexually active further education college students: study protocol for a cluster randomised feasibility trial.

Trials 2018 Jun 5;19(1):311. Epub 2018 Jun 5.

Population Health Research Institute, St George's, University of London, London, SW17ORE, UK.

Background: Sexually active young people attending London further education (FE) colleges have high rates of chlamydia, but screening rates are low. We will conduct a cluster randomised feasibility trial of frequent, rapid, on-site chlamydia testing and same-day treatment (Test and Treat (TnT)) in six FE colleges (with parallel qualitative and economic assessments) to assess the feasibility of conducting a future trial to investigate if TnT reduces chlamydia rates.

Methods: We will recruit 80 sexually active students aged 16-24 years from public areas at each of six colleges. Read More

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http://dx.doi.org/10.1186/s13063-018-2674-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989383PMC
June 2018
11 Reads

What is the true clinical relevance of and other emerging members?

New Microbes New Infect 2018 May 31;23:1-5. Epub 2018 Jan 31.

Center for Research on Intracellular Bacteria, Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.

  and are emerging related bacteria. Similar to the pathogenic organisms and these emerging bacteria are implicated in human genital infections and respiratory diseases. We used a screening strategy based on a newly developed -specific quantitative real-time PCR (qPCR) and a pan- qPCR. Read More

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http://dx.doi.org/10.1016/j.nmni.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913364PMC

PCR diagnostics of Chlamydia trachomatis in asymptomatic infection by women.

Ginekol Pol 2018 ;89(3):115-119

Department of Basic Sciences Faculty of Health Sciences Wroclaw Medical University, ul. Chałubińskiego 4,, 50-368 Wrocław, Poland.

Objectives: Chlamydial infection is often asymptomatic. The lack of symptoms may result in the infection developing into a chronic. Chlamydial infections of the genitourinary system in women can lead to serious complications like PID, fallopian tubes infertility, ectopic pregnancy, and chronic pelvic pain. Read More

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http://dx.doi.org/10.5603/GP.a2018.0020DOI Listing
July 2018
6 Reads

Chlamydia muridarum Genital and Gastrointestinal Infection Tropism Is Mediated by Distinct Chromosomal Factors.

Infect Immun 2018 07 21;86(7). Epub 2018 Jun 21.

Department of Microbiology & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Some members of the genus , including the human pathogen , infect multiple tissues, including the genital and gastrointestinal (GI) tracts. However, it is unknown if bacterial targeting to these sites is mediated by multifunctional or distinct chlamydial factors. We previously showed that disruption of individual large clostridial toxin homologs encoded within the plasticity zone were not critical for murine genital tract infection. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00141-18
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http://dx.doi.org/10.1128/IAI.00141-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013670PMC
July 2018
5 Reads

Urogenital Chlamydia trachomatis multilocus sequence types and genovar distribution in chlamydia infected patients in a multi-ethnic region of Saratov, Russia.

PLoS One 2018 11;13(4):e0195386. Epub 2018 Apr 11.

Department of Pathology, Department of Microbiology & Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, United States of America.

Background: This is the first report to characterize the prevalence and genovar distribution of genital chlamydial infections among random heterosexual patients in the multi-ethnic Saratov Region, located in Southeast Russia.

Methods: Sixty-one clinical samples (cervical or urethral swabs) collected from a random cohort of 856 patients (7.1%) were C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895025PMC
July 2018
6 Reads

Identification of a new variant of Chlamydia trachomatis in Mexico.

Enferm Infecc Microbiol Clin 2019 02 7;37(2):93-99. Epub 2018 Apr 7.

Departamento de Infectología, Instituto Nacional de Perinatología, CDMX, Mexico; Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, del Instituto Politécnico Nacional, CDMX, Mexico. Electronic address:

Introduction: Chlamydia trachomatis is one of the main etiological agents of sexually transmitted infections worldwide. In 2006, a Swedish variant of C. trachomatis (Swedish-nvCT), which has a deletion of 377bp in the plasmid, was reported. Read More

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http://dx.doi.org/10.1016/j.eimc.2018.02.008DOI Listing
February 2019
4 Reads

Distribution of genital Mollicutes in the vaginal ecosystem of women with different clinical conditions.

New Microbiol 2018 07 5;41(3):225-229. Epub 2018 Apr 5.

Microbiology, DIMES, University of Bologna, Bologna, Italy.

Ureaplasma urealyticum (UU), Ureaplasma parvum (UP), Mycoplasma hominis (MH) and Mycoplasma genitalium (MG) are the most common Mollicutes of the female genital tract. Although many studies have addressed their possible role in the vaginal ecosystem, many aspects remain to be elucidated. The aim of this study was to evaluate the vaginal presence of ureaplasmas/mycoplasmas in women with different clinical conditions. Read More

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July 2018
9 Reads

Trends in the relative prevalence of genital ulcer disease pathogens and association with HIV infection in Johannesburg, South Africa, 2007-2015.

PLoS One 2018 4;13(4):e0194125. Epub 2018 Apr 4.

Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.

Background: In South Africa, treatment of genital ulcer disease (GUD) occurs in the context of syndromic management. GUD aetiological studies have been conducted in Johannesburg since 2007. We report on GUD pathogen prevalence, sero-prevalence of STI co-infections and aetiological trends among GUD patients presenting to a community-based primary healthcare facility in Johannesburg over a 9-year period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194125PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884493PMC
July 2018
10 Reads

Variation in the microbiome of the urogenital tract of Chlamydia-free female koalas (Phascolarctos cinereus) with and without 'wet bottom'.

PLoS One 2018 26;13(3):e0194881. Epub 2018 Mar 26.

Asia Pacific Centre for Animal Health, The University of Melbourne, Parkville, Victoria, Australia.

Koalas (Phascolarctos cinereus) are iconic Australian marsupials currently threatened by several processes, including infectious diseases and ecological disruption. Infection with Chlamydia pecorum, is considered a key driver of population decline. The clinical sign of 'wet bottom', a staining of the rump associated with urinary incontinence, is often caused by chlamydial urinary tract infections. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194881PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868818PMC
July 2018
3 Reads

: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney.

Sex Transm Infect 2018 09 22;94(6):406-410. Epub 2018 Mar 22.

Western Sydney Sexual Health Centre, Parramatta, New South Wales, Australia.

Objectives: We aimed to estimate the prevalence of infection and of mutations linked to macrolide resistance using the ResistancePlus MG assay (SpeeDx, Sydney, New South Wales, Australia) in first-void urine (FVU), anorectal and oropharyngeal samples from men who have sex with men (MSM) attending Western Sydney Sexual Health Centre (WSSHC).

Methods: Consecutive symptomatic and asymptomatic MSM attending for STI testing were prospectively enrolled. testing using the ResistancePlus MG assay was performed on FVU, anorectal and oropharyngeal samples routinely collected for and assays. Read More

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http://dx.doi.org/10.1136/sextrans-2017-053480DOI Listing
September 2018
3 Reads

Identifying a consensus sample type to test for Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis and human papillomavirus.

Clin Microbiol Infect 2018 Dec 17;24(12):1328-1332. Epub 2018 Mar 17.

Department of Laboratory Medicine, Ghent University Hospital, Belgium; Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Belgium; School of Life Sciences, Hasselt University, Diepenbeek, Belgium.

Objectives: Sexually transmitted infections (STIs) are a global cause of acute illness. Early detection plays a crucial role in interrupting transmission and preventing complications. However, the accessibility of STI testing is curbed by the lack of an overall preferred sample type. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.03.013DOI Listing
December 2018
6 Reads

Oral Chlamydia vaccination induces transmucosal protection in the airway.

Vaccine 2018 04 14;36(16):2061-2068. Epub 2018 Mar 14.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, TX 78229, United States. Electronic address:

Although Chlamydia has been frequently detected in the gastrointestinal tracts of both humans and animals, it is not associated with any gastrointestinal pathology. We have recently shown that gastrointestinal Chlamydiamuridarum is not only non-pathogenic but also induces protective immunity in the genital tract. We now report that the transmucosal immunity induced by a single oral immunization with C. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.03.015DOI Listing
April 2018
4 Reads

Unusual case of a rectal tumour.

BMJ Case Rep 2018 Mar 15;2018. Epub 2018 Mar 15.

Epsom and Saint Helier University Hospitals NHS Trust, Carshalton, UK.

A 48-year-old man presented as an emergency with a 3-week history of rectal bleeding. Examination of his rectum revealed a circumferential tumour, 2 cm from the anal verge. An MRI scan reported a locally infiltrative mid-lower rectal tumour staged as T3d/T4 N2 MX. Read More

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http://dx.doi.org/10.1136/bcr-2017-223944DOI Listing
March 2018
6 Reads

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.

EBioMedicine 2018 Mar 23;29:159-165. Epub 2018 Feb 23.

MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK. Electronic address:

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial "receptivity" integrins (cell adhesion molecules). Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925620PMC
March 2018
30 Reads

Trends in adult chlamydia and gonorrhoea prevalence, incidence and urethral discharge case reporting in Mongolia from 1995 to 2016 - estimates using the Spectrum-STI model.

Western Pac Surveill Response J 2017 Oct-Dec;8(4):20-29. Epub 2017 Dec 1.

Avenir Health, Geneva, Switzerland.

Objective: To estimate Mongolia's prevalence and incidence trends of gonorrhoea and chlamydia in women and men 15-49 years old to inform control of STIs and HIV, a national health sector priority.

Methods: We applied the Spectrum-STI estimation model, fitting data from two national population surveys (2001 and 2008) and from routine gonorrhoea screening of pregnant women in antenatal care (1997 to 2016) adjusted for diagnostic test performance, male/female differences and missing high-risk populations. Prevalence and incidence estimates were then used to assess completeness of national case reporting. Read More

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http://dx.doi.org/10.5365/wpsar.2017.8.2.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803554PMC
May 2018
3 Reads
2 Citations

Protein Content of Cervicovaginal Fluid Is Altered During Bacterial Vaginosis.

J Low Genit Tract Dis 2018 Apr;22(2):147-151

Department of Pathology from Botucatu Medical School (FMB), São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

Objectives: The aim of the study was to compare, using a proteomic approach, cervicovaginal fluid (CVF) proteins of women with bacterial vaginosis (BV) with those presenting normal microbiota.

Materials And Methods: A total of 309 reproductive-aged women were cross-sectionally enrolled. Participants were tested for vaginal candidosis, Trichomonas vaginalis, Chlamydia trachomatis, and Neisseria gonorrhoeae and excluded if positive. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000367DOI Listing
April 2018
15 Reads

Epididymo-orchitis caused by enteric organisms in men > 35 years old: beyond fluoroquinolones.

Eur J Clin Microbiol Infect Dis 2018 Jun 15;37(6):1001-1008. Epub 2018 Feb 15.

Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland.

Epididymo-orchitis is a common urological condition in men of all ages, causing a unilateral or bilateral swelling of the epididymis and/or testis. It is frequently caused by sexually transmitted infections, Chlamydia trachomatis and Neisseria gonorrheae, as well as common enteric organisms implicated in urinary tract infections. Men over 35 years old may develop epididymo-orchitis associated with enteric organisms, often associated with functional bladder outlet problems such as benign prostatic hyperplasia or urethral stricture disease. Read More

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http://dx.doi.org/10.1007/s10096-018-3212-zDOI Listing
June 2018
3 Reads

Pathology after infection is driven by nonprotective immune cells that are distinct from protective populations.

Proc Natl Acad Sci U S A 2018 02 9;115(9):2216-2221. Epub 2018 Feb 9.

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

Infection with drives severe mucosal immunopathology; however, the immune responses that are required for mediating pathology vs. protection are not well understood. Here, we employed a mouse model to identify immune responses required for -induced upper genital tract pathology and to determine whether these responses are also required for bacterial clearance. Read More

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http://dx.doi.org/10.1073/pnas.1711356115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834673PMC
February 2018
3 Reads

Chlamydia trachomatis genotypes A and B from urogenital specimens of patients in Spain: molecular characterization.

Clin Microbiol Infect 2018 Aug 7;24(8):910.e5-910.e8. Epub 2018 Feb 7.

Section of Clinical Bacteriology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Objectives: Chlamydia trachomatis ompA genotypes A and B, primarily associated with trachoma, were unexpectedly detected in urogenital samples of patients in Spain, a trachoma-free country. In this study, we aimed to explain this finding using analysis of organotropism-related genes and a multilocus sequence typing (MLST) technique.

Methods: C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X183014
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http://dx.doi.org/10.1016/j.cmi.2018.01.025DOI Listing
August 2018
1 Read

Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Genital Infections.

Front Cell Infect Microbiol 2018 18;8. Epub 2018 Jan 18.

Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, Australia.

The natural course of urogenital tract infections varies between individuals. While protective immunity can occur, some women can become reinfected, contributing to the development of severe pathology. While the reasons for these differences are unknown, an individual's response to induced interferon-γ (IFN-γ) is suggested to be critical. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778109PMC
January 2019
1 Read

A 30-Min Nucleic Acid Amplification Point-of-Care Test for Genital Chlamydia trachomatis Infection in Women: A Prospective, Multi-center Study of Diagnostic Accuracy.

EBioMedicine 2018 Feb 10;28:120-127. Epub 2018 Jan 10.

Applied Diagnostic Research and Evaluation Unit, Institute for Infection and Immunity, St George's University of London, London SW17 0RE, UK; Public Health England, National Infection Service, HIV/STI Department, Colindale, London NW9 5EQ, UK; Courtyard Clinic, St George's University Hospitals NHS Foundation Trust, London, UK, SW17 0QT, UK. Electronic address:

Background: Rapid Point-Of-Care Tests for Chlamydia trachomatis (CT) may reduce onward transmission and reproductive sexual health (RSH) sequelae by reducing turnaround times between diagnosis and treatment. The io® single module system (Atlas Genetics Ltd.) runs clinical samples through a nucleic acid amplification test (NAAT)-based CT cartridge, delivering results in 30min. Read More

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http://dx.doi.org/10.1016/j.ebiom.2017.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897918PMC
February 2018
2 Reads