3,255 results match your criteria Chlamydial Genitourinary Infections


Near patient chlamydia and gonorrhoea screening and treatment in further education/technical colleges: a cost analysis of the 'Test n Treat' feasibility trial.

BMC Health Serv Res 2020 Apr 16;20(1):316. Epub 2020 Apr 16.

Population Health Research Institute, St George's, University of London, London, SW17 ORE, UK.

Background: Community-based screening may be one solution to increase testing and treatment of sexually transmitted infections in sexually active teenagers, but there are few data on the practicalities and cost of running such a service. We estimate the cost of running a 'Test n Treat' service providing rapid chlamydia (CT) and gonorrhoea (NG) testing and same day on-site CT treatment in technical colleges.

Methods: Process data from a 2016/17 cluster randomised feasibility trial were used to estimate total costs and service uptake. Read More

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http://dx.doi.org/10.1186/s12913-020-5062-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160983PMC

Call to action for health systems integration of point-of-care testing to mitigate the transmission and burden of sexually transmitted infections.

Sex Transm Infect 2020 Apr 2. Epub 2020 Apr 2.

Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.

Objectives: In 2016, WHO estimated 376 million new cases of the four main curable STIs: gonorrhoea, chlamydia, trichomoniasis and syphilis. Further, an estimated 290 million women are infected with human papillomavirus. STIs may lead to severe reproductive health sequelae. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054358DOI Listing

[Real-time fluorescence constant-temperature simultaneous amplification and testing of nucleic acid for detection of mycoplasma genitalium infection in the genitourinary tract].

Zhonghua Nan Ke Xue 2019 Jun;25(6):535-538

Department of Urology, Hangzhou Third People's Hospital, Hangzhou, Zhejiang 310009, China.

Objective: To investigate the infection of reproductive Mycoplasma genitalium (MG) detected by real-time fluorescence constant-temperature simultaneous amplification and testing (SAT) of nucleic acid among patients present at the clinics of urology, gynecology or venereal diseases.

Methods: We retrospectively analyzed the clinical data on 5 711 patients with suspected genitourinary tract (GUT) infection present at the clinics of urology, gynecology or sexually transmitted diseases in Hangzhou Third People's Hospital, Shaoxing People's Hospital and General Hospital of Eastern Theater Command from January 2018 to December 2018. The patients were aged 16-73 (38. Read More

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Proteome array of antibody responses to Chlamydia trachomatis infection in nonhuman primates.

Life Sci 2020 May 19;248:117444. Epub 2020 Feb 19.

Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address:

Aims: Nonhuman primates have been used to investigate pathogenic mechanisms and evaluate immune responses following Chlamydia trachomatis inoculation. This study aimed to systemically profile antibody responses to C. trachomatis infection in nonhuman primates. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117444DOI Listing

[Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted infections].

Urologiia 2019 12(6):31-37

State Research Center Institute of immunology of Federal Medical Biological Agency, Moscow, Russia.

Objective: to conduct a comparative study of the composition of the microbiota of the urethra in men with sexually transmitted infections (STIs), and healthy men.

Material And Methods: The study included 103 men aged 18 to 45 years: 42 men with urethritis caused by STIs and 61 clinically healthy men. Identification of pathogenic and conditionally pathogenic microorganisms in scrapings from the urethra was performed by PCR in real time (test system Androflor (DNA-Technology, Moscow). Read More

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December 2019

Multiplex nested polymerase chain reaction targeting multiple genes for the detection of and in genitourinary specimens.

Indian J Sex Transm Dis AIDS 2019 Jul-Dec;40(2):152-158

Department of Dermatology and Venerology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Objectives: The objective of this study was to design and evaluate a novel multiplex nested polymerase chain reaction (PCR) protocol for simultaneous detection of and in genitourinary specimens obtained from symptomatic patients clinically suspected of sexually transmitted infections (STIs), targeting two different genes each for these pathogens.

Materials And Methods: A total of 116 genitourinary specimens were collected from men ( = 12) and women ( = 104). Direct microscopy, culture isolation, and antimicrobial susceptibility testing for were performed. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896390PMC
January 2020

Chlamydia Trachomatis Infection in High-Risk Human Papillomavirus Based on Cervical Cytology Specimen.

Asian Pac J Cancer Prev 2019 Dec 1;20(12):3843-3847. Epub 2019 Dec 1.

Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objective: High-risk human papillomavirus (HR HPV) was associated with the development of cervical cancer. Asymptomatic Chlamydia trachomatis (C. trachomatis) infection is the most common bacterial, sexually-transmitted infection. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.12.3843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173371PMC
December 2019
1.500 Impact Factor

[Screening of cervical sexually transmitted infections in pregnant women and the relation with the vaginal microbiota].

Rev Chilena Infectol 2019 Jun;36(3):292-298

Servicio de Dermatología y Venereología, Hospital San José, Santiago, Chile.

Background: Pregnant woman is exposed to many sexual transmitted infections (STI). Many of these infections may produce diseases in the fetus and newborn, and also alteration in the normal course of the pregnancy.

Aim: Screening of asymptomatic cervical infection in pregnant woman and its relationship with the vaginal microbiota. Read More

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http://dx.doi.org/10.4067/S0716-10182019000300292DOI Listing

Comparative analysis of the vaginal microbiome of pregnant women with either Trichomonas vaginalis or Chlamydia trachomatis.

PLoS One 2019 12;14(12):e0225545. Epub 2019 Dec 12.

KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.

Background: Although the significance of the human vaginal microbiome for health and disease is increasingly acknowledged, there is paucity of data on the differences in the composition of the vaginal microbiome upon infection with different sexually transmitted pathogens.

Method: The composition of the vaginal bacterial community of women with Trichomonas vaginalis (TV, N = 18) was compared to that of women with Chlamydia trachomatis (CT, N = 14), and to that of controls (N = 21) (women negative for TV, CT and bacterial vaginosis). The vaginal bacterial composition was determined using high throughput sequencing with the Ion 16S metagenomics kit of the variable regions 2, 4 and 8 of the bacterial 16S ribosomal RNA gene from the vaginal swab DNA extract of the women. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907840PMC

Dissemination of Chlamydia from the reproductive tract to the gastro-intestinal tract occurs in stages and relies on Chlamydia transport by host cells.

PLoS Pathog 2019 12 2;15(12):e1008207. Epub 2019 Dec 2.

School of Biological Sciences, Microbiology Program, Southern Illinois University, Carbondale, Illinois, United States of America.

Chlamydia trachomatis is a Gram-negative bacterial pathogen and a major cause of sexually transmitted disease and preventable blindness. In women, infections with C. trachomatis may lead to pelvic inflammatory disease (PID), ectopic pregnancy, chronic pelvic pain, and infertility. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907867PMC
December 2019

Increase in genital and extra-genital infections in Indian males.

Indian J Med Microbiol 2019 Apr-Jun;37(2):285-286

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ijmm.IJMM_19_7DOI Listing

Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia.

PLoS One 2019 18;14(11):e0224658. Epub 2019 Nov 18.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224658PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860443PMC

Correlations between infection patterns and eye damage in reactive arthritis.

Rom J Morphol Embryol 2019 ;60(2):601-604

Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania;

The purpose of the study was to correlate the infectious patterns (urogenital, enteral) with ocular manifestations, such as conjunctivitis or acute anterior uveitis in reactive arthritis (ReA). The transversal, observational study was conducted in the Clinic of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, during the period 2012-2015, and included 112 patients. They were divided into three groups, as follows: Group I (52 ReA cases), Group II (30 other spondyloarthritis cases), Group III (40 osteoarthritis cases). Read More

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March 2020
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Rapid and accurate diagnosis of in the urogenital tract by a dual-gene multiplex qPCR method.

J Med Microbiol 2019 Dec;68(12):1732-1739

Department of Clinical Laboratory, Central Research Laboratory, The Second People's Hospital of Bao'an Shenzhen (Group), Shajing People's Hospital of Bao'an Shenzhen, Shenzhen Shajing Hospital affiliated to Guangzhou Medical University, Shenzhen, PR China.

(, CT) is an obligatory intracellular bacterium that causes urogenital tract infections and leads to severe reproductive consequences. Therefore, a rapid and accurate detection method with high sensitivity and specificity is an urgent requirement for the routine diagnosis of infections. In this study, we aimed to develop a multiplex quantitative real-time PCR (qPCR) assay based on two target regions for accurate detection of in urogenital tract infections. Read More

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http://dx.doi.org/10.1099/jmm.0.001084DOI Listing
December 2019
1 Read

Chlamydial infection and on-farm risk factors in dairy cattle herds in South East Queensland.

Aust Vet J 2019 Dec 7;97(12):505-508. Epub 2019 Oct 7.

Genecology Research Centre, University of the Sunshine Coast, 90 Sippy Downs Drive, Sippy Downs, Queensland, 4557, Australia.

Chlamydial infections in dairy cattle are common and have been sporadically associated with reduced performance and severe disease manifestations. While chlamydial infections are well described in sheep, very little is known about the epidemiology of these infections in dairy cattle in Australia. In this study, we screened for chlamydial infections and assessed on-farm risks in dairy cattle herds from Southeast Queensland (SE Qld) region of Australia. Read More

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http://dx.doi.org/10.1111/avj.12879DOI Listing
December 2019

UROGENITAL MALASSEZIOSIS IN MEN: FEATURES OF THE CLINICAL COURSE AND MANIFESTATIONS.

Georgian Med News 2019 Jul-Aug(292-293):7-11

State Establishment "Dnipropetrovsk Medical Academy of Health Ministry of Ukraine", Ukraine.

The Aim Of The Study: determining the features of the clinical manifestations of malassezial infection of the genital organs in men. The main research group included 148 men who revealed the malassezia genital infection. The comparison group included 126 men having been examined for STIs and diagnosed with chlamydia, mycoplasma, trichomonas infection and candidiasis and having not been diagnosed with malassezial infection. Read More

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November 2019
1 Read

Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections.

Int J Nanomedicine 2019 30;14:5957-5976. Epub 2019 Jul 30.

Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø the Arctic University of Norway, 5037 Tromsø, Norway.

Background: Efficient localized cervicovaginal antibacterial therapy, enabling the delivery of antibiotic to the site of action at lower doses while escaping systemic drug effects and reducing the risk of developing microbial resistance, is attracting considerable attention. Liposomes have been shown to allow sustained drug release into vaginal mucosa and improve delivery of antibiotics to bacterial cells and biofilms. Azithromycin (AZI), a potent broad-spectrum macrolide antibiotic, has not yet been investigated for localized therapy of cervicovaginal infections, although it is administered orally for the treatment of sexually transmitted diseases. Read More

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http://dx.doi.org/10.2147/IJN.S211691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679693PMC
November 2019
1 Read

The Cervicovaginal Microbiota-Host Interaction Modulates Chlamydia trachomatis Infection.

mBio 2019 08 13;10(4). Epub 2019 Aug 13.

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

The mechanism(s) by which -dominated cervicovaginal microbiota provide a barrier to infection remain(s) unknown. Here we evaluate the impact of different spp. identified via culture-independent metataxonomic analysis of -infected women on infection in a three-dimensional (3D) cervical epithelium model. Read More

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http://dx.doi.org/10.1128/mBio.01548-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692509PMC
August 2019
2 Reads

Difference in vaginal microecology, local immunity and HPV infection among childbearing-age women with different degrees of cervical lesions in Inner Mongolia.

BMC Womens Health 2019 08 12;19(1):109. Epub 2019 Aug 12.

Department of Obstetrics and Gynecology, Inner Mongolia Maternal and Child Health Care Hospital, Huhhot, 010020, Inner Mongolia, China.

Background: This study aims to investigate the difference in vaginal microecology, local immunity and HPV infection among childbearing-age women with different degrees of cervical lesions.

Methods: A total of 432 patients were included in this study. Among these patients, 136 patients had LSIL, 263 patients had HSIL and 33 patients had CSCC. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0806-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689872PMC
August 2019
1 Read

Enumeration of Viable Chlamydia from Infected Animals Using Immunofluorescent Microscopy.

Methods Mol Biol 2019 ;2042:237-244

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

An appropriate means of quantitating infectious Chlamydia from infected animals is essential for the evaluation of vaccines. However, unlike methods involving culture, nonculture methods, including detection of antigen or DNA, are not able to differentiate between viable and nonviable organisms. As an obligate intracellular bacterium, Chlamydia replicates inside host cells by forming unique organelles called inclusions. Read More

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http://dx.doi.org/10.1007/978-1-4939-9694-0_16DOI Listing

Identification and Discrimination of Chlamydia trachomatis Ocular and Urogenital Strains and Major Phylogenetic Lineages by CtGEM Typing, A Double-Locus Genotyping Method.

Methods Mol Biol 2019 ;2042:87-122

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

CtGEM typing was developed to subdivide the bacterial species Chlamydia trachomatis on the basis of genome phylogeny and anatomical tropism. The rationale was facilitation of surveillance for ocular strains, although the method is applicable to essentially any C. trachomatis surveillance application that does not require high resolution. Read More

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http://dx.doi.org/10.1007/978-1-4939-9694-0_8DOI Listing

Point-of-Care Chlamydia trachomatis Detection Using Loop-Mediated Isothermal Amplification and Hydroxynaphthol Blue.

Methods Mol Biol 2019 ;2042:11-17

Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

Loop-mediated isothermal amplification (LAMP) is a new nucleic acid amplification technique that provides high sensitivity and specificity compatible to conventional polymerase chain reaction (PCR) and simplicity, without the requirement of an expensive thermal cycler. Additionally, LAMP coupled hydroxynaphthol blue (HNB) allowed for visual color detection by the naked eye. Here we describe the methodology of Chlamydia trachomatis detection of vaginal swab from crude DNA lysis to LAMP-HNB reaction. Read More

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http://dx.doi.org/10.1007/978-1-4939-9694-0_2DOI Listing
April 2020
2 Reads

Chlamydia-infected macrophages are resistant to azithromycin treatment and are associated with chronic oviduct inflammation and hydrosalpinx development.

Immunol Cell Biol 2019 11 11;97(10):865-876. Epub 2019 Sep 11.

Institute of Health and Biomedical Innovation (IHBI), School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.

Chlamydia infection remains the leading sexually-transmitted bacterial infection worldwide, causing damaging sequelae such as tubal scarring, infertility and ectopic pregnancy. As infection is often asymptomatic, prevention via vaccination is the optimal strategy for disease control. Vaccination strategies aimed at preventing bacterial infection have shown some promise, although these strategies often fail to prevent damaging inflammatory pathology when Chlamydia is encountered. Read More

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http://dx.doi.org/10.1111/imcb.12285DOI Listing
November 2019
3 Reads
4.147 Impact Factor

Molecular epidemiology of bacterial vaginosis and its association with genital micro-organisms in asymptomatic women.

J Med Microbiol 2019 Sep 24;68(9):1373-1382. Epub 2019 Jul 24.

Division Academica Multidisciplinaria de Comalcalco, Universidad Juarez Autonoma de Tabasco, Magisterial, Mexico.

. Bacterial vaginosis (BV) is dysbiosis associated with an increased risk of several sexually transmitted infections. It is primarily diagnosed via Gram staining, although molecular analyses have presented higher diagnostic accuracy. Read More

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http://dx.doi.org/10.1099/jmm.0.001044DOI Listing
September 2019
2 Reads

Molecular Detection of Pathogens Causing Sexually Transmissible Infections in Patients with Prostate Cancer and Hyperplasia by Quantitative TaqMan Real-Time PCR Assay.

Clin Lab 2019 Jul;65(7)

Background: Prostate cancer is considered the most prevalent cancer among men. Recent studies suggest that sex-ually transmissible infections (STIs) may be related to prostate carcinogenesis. Therefore, the aim of this study was to investigate whether STI pathogens (Atopobium vaginae (ATO), Neisseria gonorrhoeae (NG), Chlamydia tra-chomatis (CT), Treponema pallidum (TP), Ureaplasma urealyticum (UU), Gardnerella vaginalis (GV), Herpes Sim-plex Virus (HSV), Cytomegalovirus (CMV), Human herpesvirus (HHV), Human papillomavirus (HPV), and Tricho-monas vaginalis (TV)) presence in prostate tissues are associated with the risk of prostate cancer. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.181243DOI Listing
July 2019
7 Reads

Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman.

Arch Gynecol Obstet 2019 09 8;300(3):641-645. Epub 2019 Jul 8.

Department of Gynecology and Obstetrics, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Purpose: Factors influencing fallopian tube occlusion in women with a lower genital tract infection remain incompletely elucidated. We evaluated whether a polymorphism in the mannose-binding lectin (MBL) gene at codon 54 influences the occurrence of fallopian tube blockage in relation to exposure to Chlamydia trachomatis.

Methods: In a case-control study at The Hospital das Clínicas, University of São Paulo, Brazil, 75 women with hysterosalpingography-documented tubal occlusion and 75 women with patent fallopian tubes were analyzed for detection of single-nucleotide polymorphism in codon 54 of the MBL gene and for IgG anti-C. Read More

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http://dx.doi.org/10.1007/s00404-019-05231-8DOI Listing
September 2019
3 Reads

Prevalence of gonorrhea and chlamydia in a community clinic for men who have sex with men in Lisbon, Portugal.

Int J STD AIDS 2019 09 8;30(10):951-959. Epub 2019 Jul 8.

6 Scientific Coordinator of CheckpointLX, Grupo de Ativistas em Tratamentos, Lisbon, Portugal.

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http://dx.doi.org/10.1177/0956462419855484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732818PMC
September 2019
2 Reads

Clinical pharmacokinetics of oral azithromycin in epididymal tissue.

J Infect Chemother 2019 Oct 27;25(10):832-834. Epub 2019 Jun 27.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Objectives: Chlamydia trachomatis is one of the major pathogens causing acute epididymitis. Azithromycin (AZM) has a good efficacy against C. trachomatis; however, the ability of AZM to penetrate into human epididymal tissue has not yet been fully elucidated. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.05.011DOI Listing
October 2019
4 Reads

2019 European guideline on the management of lymphogranuloma venereum.

J Eur Acad Dermatol Venereol 2019 Oct 26;33(10):1821-1828. Epub 2019 Jun 26.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

New or important issues in this updated version of the 2013 European guideline on the management of lymphogranuloma venereum (LGV): EPIDEMIOLOGY: Lymphogranuloma venereum continues to be endemic among European men who have sex with men (MSM) since 2003. Lymphogranuloma venereum infections in heterosexuals are extremely rare in Europe, and there is no evidence of transmission of LGV in the European heterosexual population.

Aetiology And Transmission: Chlamydia trachomatis serovars/genovars L2b and L2 are the causative strains in the majority of cases in Europe. Read More

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http://dx.doi.org/10.1111/jdv.15729DOI Listing
October 2019
10 Reads

A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains.

Pathog Dis 2019 04;77(3)

Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, China.

Objective: This study is to investigate the functions of newly discovered genes in Chlamydia muridarum (C. muridarum) strains with single gene differences.

Methods: Using whole genome sequencing and plaque formation assays, C. Read More

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http://dx.doi.org/10.1093/femspd/ftz017DOI Listing
April 2019
2 Reads

Prevalence and Risk Factors of Trichomonas vaginalis Among Female Sexual Workers in Nairobi, Kenya.

Sex Transm Dis 2019 07;46(7):458-464

Kenya Medical Research Institute (KEMRI), Nairobi, Kenya, and.

Background: Trichomonas vaginalis (TV) is the most common curable sexually transmitted infection (STI) worldwide. Trichomonas vaginalis infection is associated with an increased risk of pelvic inflammatory disease, human immunodeficiency virus transmission, and preterm birth in women. Data on the prevalence and risk factors for TV infection in sub-Saharan African countries remain scarce. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001002DOI Listing
July 2019
14 Reads
2.842 Impact Factor

Myosalpinx Contractions Are Essential for Egg Transport Along the Oviduct and Are Disrupted in Reproductive Tract Diseases.

Adv Exp Med Biol 2019 ;1124:265-294

Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.

Oviducts (also called fallopian tubes) are smooth muscle-lined tubular organs that at one end extend in a trumpet bell-like fashion to surround the ovary, and at the other connect to the uterus. Contractions of the oviduct smooth muscle (myosalpinx) and the wafting motion of the ciliated epithelium that lines these tubes facilitate bidirectional transport of gametes so that newly released ovum(s) are transported in one direction (pro-uterus) while spermatozoa are transported in the opposite direction (pro-ovary). These transport processes must be temporally coordinated so that the ovum and spermatozoa meet in the ampulla, the site of fertilization. Read More

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http://dx.doi.org/10.1007/978-981-13-5895-1_11DOI Listing
August 2019
5 Reads

Selected Immunological Mediators and Cervical Microbial Signatures in Women with Chlamydia trachomatis Infection.

mSystems 2019 Jun 4;4(4). Epub 2019 Jun 4.

Section of Microbiology, Department of Public Health and Infectious Diseases, University of Rome "Sapienza," Rome, Italy.

In the female genital ecosystem, the complex interplay between the host immune system and the resident microflora protects against urogenital pathogens, like is responsible for urethritis and cervicitis; however, most chlamydial infections are asymptomatic and, thus, not treated, potentially leading to severe reproductive sequelae. Here we investigated the interaction between the levels of selected immune mediators and the community state types of the cervical microbiota in -infected women. Cervical samples from 42 -positive women and 103 matched healthy controls were analyzed through the metagenomic analysis of the hypervariable region v4 of the 16S rRNA gene and the determination of lactoferrin, interleukin 1α (IL-1α), IL-6, alpha interferon (IFN-α), IFN-β, and IFN-γ by ELISA. Read More

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http://dx.doi.org/10.1128/mSystems.00094-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550367PMC
June 2019
23 Reads

How conquered gut microbiome-derived antimicrobial compounds and found a new home in the eye.

Proc Natl Acad Sci U S A 2019 06 4;116(25):12136-12138. Epub 2019 Jun 4.

Department of Microbiology, Indiana University School of Medicine, Indianapolis IN 46202

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http://dx.doi.org/10.1073/pnas.1907647116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589746PMC
June 2019
6 Reads

Nonsexually Transmitted Genital Ulcer Secondary to Hand, Foot, and Mouth Disease.

Obstet Gynecol 2019 06;133(6):1269-1273

Sunrise Health GME Consortium, Residency Program in Obstetrics and Gynecology, and the Department of Obstetrics and Gynecology, University of Nevada, Las Vegas, School of Medicine, Las Vegas, Nevada.

Background: Genital ulcers that are not the result of sexually transmitted infections (STIs) are uncommon, and case reports predominantly feature pubertal girls.

Case: A 38-year-old monogamous, nulliparous woman acutely developed painful vaginal ulcers 7 days after babysitting a child who was subsequently diagnosed with hand, foot, and mouth disease. The patient developed nonspecific systemic symptoms followed by painful and rapidly expanding genital ulcers. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003268DOI Listing
June 2019
17 Reads

Prevalence of genital and oropharyngeal chlamydia and gonorrhoea among female sex workers in Melbourne, Australia, 2015-2017: need for oropharyngeal testing.

Sex Transm Infect 2019 09 21;95(6):398-401. Epub 2019 May 21.

Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Objective: The Victorian legislation requires sex workers to have quarterly screening for genital chlamydia and gonorrhoea, but screening for oropharyngeal infection is not mandatory in Victoria, Australia. In 2017, oropharyngeal screening for gonorrhoea and chlamydia was added as part of the routine quarterly screening for sex workers attending the Melbourne Sexual Health Centre (MSHC). The aim of this study was to examine the prevalence of oropharyngeal gonorrhoea and chlamydia among female sex workers (FSW). Read More

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http://dx.doi.org/10.1136/sextrans-2018-053957DOI Listing
September 2019
5 Reads

Reply to Dukers-Muijrers et al.

J Infect Dis 2019 09;220(8):1390-1391

Department of Epidemiology, University of Washington, Seattle.

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http://dx.doi.org/10.1093/infdis/jiz268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743832PMC
September 2019

Vaginal herb use and infection: cross-sectional study among women of various ethnic groups in Suriname.

BMJ Open 2019 05 16;9(5):e025417. Epub 2019 May 16.

Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands.

Objective: Vaginal steam baths with herb leaves (herb use) is practised by some Surinamese women. We assessed herb use among women from the five most prevalent ethnic groups, and if herb use is associated with infection.

Setting: Participants were recruited at a sexually transmitted infection (STI) clinic and a family planning clinic (FP) in Paramaribo, Suriname. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530446PMC
May 2019
3 Reads

Genital and anal bacterial load in concurrently infected women: a cross-sectional study.

Sex Transm Infect 2019 08 16;95(5):317-321. Epub 2019 May 16.

Department of Medical Microbiology, School of Public Health and Primary Care (CAPHRI), Maastricht University Medical Center, Maastricht, The Netherlands.

Objectives: Most international STI guidelines recommend anorectal testing in women after self-reported sexual exposure or symptoms in women. However, it has been shown that the prevalence of anorectal is as high (7%-17 %) in women who do not report anorectal intercourse (AI) as in women who do. This study assessed the correlation between the genital and anorectal load in concurrently infected women for increased microbiological insight. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053678DOI Listing
August 2019
8 Reads

Ammonia generation by tryptophan synthase drives a key genetic difference between genital and ocular isolates.

Proc Natl Acad Sci U S A 2019 06 16;116(25):12468-12477. Epub 2019 May 16.

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA 70112

A striking difference between genital and ocular clinical isolates of is that only the former express a functional tryptophan synthase and therefore can synthesize tryptophan by indole salvage. Ocular isolates uniformly cannot use indole due to inactivating mutations within tryptophan synthase, indicating a selection against maintaining this enzyme in the ocular environment. Here, we demonstrate that this selection occurs in two steps. Read More

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http://dx.doi.org/10.1073/pnas.1821652116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589672PMC

Chlamydia muridarum Induces Pathology in the Female Upper Genital Tract via Distinct Mechanisms.

Infect Immun 2019 08 23;87(8). Epub 2019 Jul 23.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

Sexually transmitted infection with may lead to fibrotic blockage in women's upper genital tracts, resulting in tubal infertility. Intravaginal inoculation with readily induces fibrotic blockage or hydrosalpinx in mice and is used for investigating pathogenicity. Using this model in combination with an antibody depletion approach, we confirmed CD4 T cell-mediated protective immunity and a CD8 T cell-dependent pathogenic mechanism during chlamydial infection in C57BL/6J mice. Read More

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http://dx.doi.org/10.1128/IAI.00145-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652751PMC
August 2019
1 Read

Prevalence of human papillomavirus, human immunodeficiency virus and other sexually transmitted infections among female sex workers in Togo: a national cross-sectional survey.

Clin Microbiol Infect 2019 Dec 30;25(12):1560.e1-1560.e7. Epub 2019 Apr 30.

Université de Lomé, Centre de Biologie Moléculaire et d'Immunologie, Lomé, Togo; Programme national de lutte contre le sida et les infections sexuellement transmissibles, Lomé, Togo.

Objectives: Sub-Saharan Africa is a region with high incidence of both human immunodeficiency virus (HIV) and cervical cancer. We conducted the first national study in Togo to assess prevalence of human papillomavirus (HPV), HIV and other sexually transmitted infections (STIs) among female sex workers (FSW).

Methods: A multicentric cross-sectional study was conducted among FSW recruited in hot spots (clubs, streets) in four Togolese cities. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.015DOI Listing
December 2019
6 Reads
5.768 Impact Factor

Sexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples.

PLoS One 2019 23;14(4):e0215001. Epub 2019 Apr 23.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

The anogenital prevalence of sexually transmitted infections (STIs) and the use of cervico-vaginal self-collected vs. clinician-collected samples were evaluated for the diagnosis of human immunodeficiency virus (HIV)-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil. We recruited 153 women for a cross-sectional study (112 HIV-uninfected and 41 HIV-infected) who sought health services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478302PMC
December 2019
9 Reads

Chlamydia trachomatis bacterial load, estimated by Cq values, in urogenital samples from men and women visiting the general practice, hospital or STI clinic.

PLoS One 2019 19;14(4):e0215606. Epub 2019 Apr 19.

Department of Medical Microbiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center (MUMC+), AZ Maastricht, the Netherlands.

Background: The bacterial load of Chlamydia trachomatis (CT) is assumed to play a role in transmission and sequelae. We assessed urogenital CT cycle quantification (Cq) values, as an indicator for CT load, of men and women diagnosed by general practitioners (GPs), hospital physicians and the STI clinic.

Methods: Urogenital CT-positive samples (n = 2,055 vaginal swabs, n = 77 cervical swabs, n = 1,519 urine samples and n = 19 urethral swabs) diagnosed by GPs, hospital physicians and the STI clinic from the Maastricht Medical Microbiology Laboratory were included (2012-2016). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474615PMC
January 2020
4 Reads

The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection.

Papillomavirus Res 2019 06 13;7:154-163. Epub 2019 Apr 13.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa. Electronic address:

In this study we examined potential associations of HPV infection with the cervical microbiota. Cervical samples were collected from 87 HIV-seronegative reproductive-age Black South African women. Microbiota were characterized by Illumina sequencing of the V3-V4 hypervariable regions of the bacterial 16S rRNA gene. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475661PMC
June 2019
10 Reads

High burden of chlamydia and gonorrhoea in pharyngeal, rectal and urethral sites among Thai transgender women: implications for anatomical site selection for the screening of STI.

Sex Transm Infect 2019 11 13;95(7):534-539. Epub 2019 Apr 13.

PREVENTION, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Objective: Comprehensive data on (CT) and (NG) infections to guide screening services among transgender women (TGW) are limited. We studied the burden of CT/NG infections in pharyngeal, rectal and urethral sites of Thai TGW and determined missed CT/NG diagnoses if selected site screening was performed.

Methods: Thai TGW were enrolled to the community-led test and treat cohort. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053835DOI Listing
November 2019
8 Reads

Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.

PLoS One 2019 4;14(4):e0213975. Epub 2019 Apr 4.

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

The genital tract of African women has been shown to differ from what is currently accepted as 'normal', defined by a pH≤4.5 and lactobacilli-dominated microbiota. Adolescent girls and young women (AGYW) from sub-Saharan Africa are at high risk for HIV, and we hypothesized that specific biological factors are likely to be influential. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213975PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448899PMC
December 2019
28 Reads

Evaluation of the BD MAX™ Vaginal Panel for the detection of vaginal infections in a sexual health service in the UK.

Authors:
Jackie Sherrard

Int J STD AIDS 2019 03 8;30(4):411-414. Epub 2019 Jan 8.

Department of Sexual Health, Buckinghamshire Healthcare NHS Trust, Wycombe General Hospital, Wycombe, UK.

The aim of this study is to compare the performance of the BD MAX™ Vaginal Panel (Becton, Dickinson and company, Franklin Lakes, NJ, USA) in the diagnosis of bacterial vaginosis (BV), candidiasis and trichomoniasis with current standard tests in a UK specialist sexual health service. Women with abnormal vaginal discharge attending the service who had not used douches or vaginal treatment in the preceding 48 hours had two vulvovaginal swabs taken: one for Chlamydia and gonorrhoea nucleic acid amplification test (NAAT) and one for testing on the BD MAX™ Vaginal Panel on the BD MAX System. Speculum examination was then performed and vaginal swabs taken for vaginal pH, and microscopy of vaginal secretions: Gram stain for Candida and BV using the Hay-Ison score and wet-mount for clue cells and Trichomonas vaginalis (TV). Read More

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http://dx.doi.org/10.1177/0956462418815284DOI Listing
March 2019
15 Reads

Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997-2011.

BMJ Open 2019 03 30;9(3):e026297. Epub 2019 Mar 30.

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Objective: To assess the association between occurrence and timing of maternal self-reported genitourinary tract infection (urinary tract infections [UTIs] and/or sexually transmitted infection [STI]) and risk for gastroschisis in the offspring.

Design: Population-based case-control study.

Setting: National Birth Defects Prevention Study, a multisite study in the USA. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475179PMC
March 2019
24 Reads

Association of Sexually Transmitted Diseases With Cervical Ectopy: A Systematic Review.

Sex Transm Dis 2019 07;46(7):452-457

From the Gynecology Department, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Objective: The aim of this study was to review the available literature to explore evidence indicating an association between cervical ectopy and sexually transmitted diseases, which could help in the decision to treat or not to treat this condition.

Methods: A review of the literature was conducted using the PubMed, EMBASE and clinicaltrials.gov databases on ectopy of the cervix using the terms "ectopy OR ectropium AND cervix" filtered only by language, without limit of date. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000992DOI Listing
July 2019
20 Reads