28,437 results match your criteria Chlamydia


How actively should we screen for chlamydia and gonorrhoea in MSM and other high-ST-prevalence populations as we enter the era of increasingly untreatable infections? A viewpoint.

Authors:
Chris Kenyon

J Med Microbiol 2018 Dec 6. Epub 2018 Dec 6.

2​Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory 7700, South Africa.

A number of national and international organizations are advocating more intensive screening for Chlamydia trachomatis and Neisseria gonorrhoeae in high-prevalence populations as a way to reduce the prevalence of these infections. In this article, we review the available evidence and conclude that there is a paucity of evidence to support this approach. We further hypothesize that increasing screening intensity in high-prevalence populations will result in a considerable risk for the emergence of antimicrobial resistance in Neisseria gonorrhoeae and other pathobionts. Read More

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December 2018

Contraceptive use and the risk of sexually transmitted infection: systematic review and current perspectives.

Open Access J Contracept 2018 12;9:91-112. Epub 2018 Nov 12.

Global Health, Population and Nutrition, FHI 360, Durham, NC, USA,

Purpose: Evidence on the association between contraceptive use and risk of sexually transmitted infections (STIs) and bacterial vaginosis (BV) is lacking, with few prospective studies. We systematically reviewed the last 10 years' evidence on the association between contraception and STI/BV, building on the most recent systematic reviews published in 2006 and 2009.

Methods: We searched the MEDLINE and POPLINE databases for peer-reviewed articles p ublished between January 1, 2008 and January 31, 2018 reporting prospective studies that assessed the association between contraceptive use and incident STI and/or incident or recurrent BV. Read More

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November 2018

Non-standard treatment for uncomplicated urogenital infections: a systematic review.

BMJ Open 2018 Dec 4;8(12):e023808. Epub 2018 Dec 4.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To review the literature for non-standard treatment options for uncomplicated (CT) infections in adolescents and adults.

Design: Systematic review.

Data Sources: Ovid MEDLINE/PubMed, Ovid EMBASE, Cochrane Trials & Systematic Review Databases, CINAHL Plus with Full Text, Web of Science Core Collection, Scopus, ProQuest Dissertations & Theses Global, ClinicalTrials. Read More

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December 2018

Lymphoganuloma venereum in the Western world, 15 years after its re-emergence: new perspectives and research priorities.

Curr Opin Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Infectious Diseases, STI Outpatient Clinic, Public Health Service of Amsterdam.

Purpose Of Review: Lymphogranuloma venereum (LGV) is a serious sexually transmitted infection caused by Chlamydia trachomatis. If left untreated LGV can cause irreversible late sequelae. LGV is endemic among a high-risk population of men who have sex with men (MSM), and largely reported in Western metropoles. Read More

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November 2018
1 Read

Adult conjunctivitis secondary to dual infection with and - A case report.

Am J Ophthalmol Case Rep 2019 Mar 14;13:6-8. Epub 2018 Nov 14.

Manchester Royal Eye Hospital, Oxford Road, Manchester, M13 9WL, UK.

Purpose: Although and are the commonest sexually transmitted infections in England, reports of ocular co-infection in the literature are limited. We report such a case which responded well to treatment, and discuss the literature and evidence currently available with regards to management of these cases.

Observations: The patient is a 48-year-old bisexual gentleman who presented to the eye clinic of a UK hospital with redness, discharge and blurred vision in his left eye for one week. Read More

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The molecular mechanism of induction of unfolded protein response by Chlamydia.

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA. Electronic address:

The unfolded protein response (UPR) contributes to chlamydial pathogenesis, as a source of lipids and ATP during replication, and for establishing the initial anti-apoptotic state of host cell that ensures successful inclusion development. The molecular mechanism(s) of UPR induction by Chlamydia is unknown. Chlamydia use type III secretion system (T3SS) effector proteins (e. Read More

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November 2018

Prediction of epitopes of Neisseria Gonorrhoeae against USA human leukocyte antigen background: An immunoinformatic approach towards development of future vaccines for USA population.

Mol Cell Probes 2018 Nov 28. Epub 2018 Nov 28.

Department of Biochemistry and Biotechnology, University of Gujrat, P. O Box No, 50700, Pakistan. Electronic address:

Gonorrheal infections are the second most prevalent sexually transmitted diseases STDs in the USA populations after Chlamydia. These infections have now become an urgent problem to address because Neisseria gonorrhoeae is capable of developing resistance to multiple antibiotic classes. Infection with these antibiotic-resistant strains has become the major public health concern. Read More

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November 2018

Prevalence of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae and herpes simplex virus in Beijing, China.

Epidemiol Infect 2018 Dec 3:1-5. Epub 2018 Dec 3.

Department of Infection Control,Affiliated Hospital of Academy of Military Medical Sciences,Beijing,China.

The prevalence of sexually transmitted infection (STI) pathogens in Beijing, China, is rarely reported. In this study, 34 911 symptomatic outpatients with suspected genital infections who attended outpatient clinics in a tertiary care hospital were included to investigate the updated prevalence of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and herpes simplex virus (HSV) from 1 January 2013 to 31 December 2016 in Beijing, China. Results indicated that a decrease trend (UU, CT, NG and HSV) in male and an increase trend (UU, CT and NG) in female were observed during the period. Read More

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December 2018

In vitro activity of Omadacycline against .

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, NY USA.

The activity of omadacycline, azithromycin, doxycycline, moxifloxacin and levofloxacin, was tested against 15 isolates of The minimum inhibitory concentrations at which 90% of the isolates of were inhibited (MIC) by omadacycline were 0.25 μg/ml (range 0.03-0. Read More

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December 2018

Differences in Chlamydia trachomatis seroprevalence between ethnic groups cannot be fully explained by socioeconomic status, sexual healthcare seeking behavior or sexual risk behavior: a cross-sectional analysis in the HEalthy LIfe in an Urban Setting (HELIUS) study.

BMC Infect Dis 2018 Dec 3;18(1):612. Epub 2018 Dec 3.

Molecular Diagnostics of Oncogenic Infections Division, German Cancer Research Center (Deutsches Krebsforschungszentrum DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Background: In the Netherlands, there are strong disparities in Chlamydia trachomatis (CT) prevalence between ethnic groups. The current study aims to identify whether socioeconomic status, sexual risk behavior and sexual healthcare seeking behavior may explain differences in CT seroprevalence between ethnic groups.

Methods: We used 2011-2014 baseline data of the HELIUS (HEalthy LIfe in an Urban Setting) study, a multi-ethnic population-based cohort study in Amsterdam, the Netherlands, including participants from Dutch, African Surinamese, South-Asian Surinamese, Ghanaian, Moroccan and Turkish origin. Read More

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December 2018

High prevalence of sexual Chlamydia trachomatis infection in young women from Marajó Island, in the Brazilian Amazon.

PLoS One 2018 29;13(11):e0207853. Epub 2018 Nov 29.

Laboratório de Biologia Molecular e Celular, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil.

Background: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) in the world. Approximately 80% of infected women are asymptomatic, although this infection can lead to serious complications in the female reproductive tract. Few data on Chlamydia infection are available in rural Amazonian communities. Read More

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November 2018

Neonatal conjunctivitis in the New Zealand Midland region.

N Z Med J 2018 Nov 30;131(1486):9-17. Epub 2018 Nov 30.

Ophthalmologist, Clinical Senior Lecturer, Ophthalmology Department, Department of Medicine, Hauora Tairawhiti, University of Otago, Gisborne.

Aims: To assess the incidence of chlamydial and gonorrhoeal neonatal conjunctivitis (CON and GON), across six district health boards in the greater Midland region of New Zealand.

Methods: All positive nucleic acid amplification test (NAAT) eye swabs for Chlamydia trachomatis and NAAT and bacterial eye swabs for Neisseria gonorrhoeae in infants under one year of age were retrieved from three laboratories from 2013-2016. Incidence density rates were calculated using births information from Statistics New Zealand. Read More

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November 2018
3 Reads

Comparative genomics of HORMA domain-containing proteins in prokaryotes and eukaryotes.

Cell Cycle 2018 Nov 29. Epub 2018 Nov 29.

a Biology Department, College of Science and Humanities , Prince Sattam bin Abdulaziz University , P.O. Box: 83, Al-Kharj , 11940 , Saudi Arabia .

In eukaryotes, critical regulation of cell cycle is required to ensure the integrity of cell division. HORMA-containing proteins include various proteins that contain HORMA domain and play important role in the regulation of cell cycle in eukaryotes. Many types of HORMA-containing proteins are found in eukaryotes, but their role in prokaryotes has not been proven. Read More

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November 2018
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Chlamydia trachomatis infection in women living in remote areas in Amazonas, Brazil-a self-collection screening experience.

Int J STD AIDS 2018 Nov 28:956462418809297. Epub 2018 Nov 28.

1 Federal University of Amazonas, Manaus, Brazil.

Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection among women. In Brazil, there is no organized screening program for C. trachomatis, and the actual prevalence of infection is unknown. Read More

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November 2018

Molecular diagnosis of genital tract infections among HIV-positive women in Iran.

Iran J Microbiol 2018 Aug;10(4):233-241

Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Objectives: Human immunodeficiency virus (HIV)-infected women are usually at a higher risk of sexually transmitted infections (STIs) than others. The objective of this study was to characterize the prevalence of human papilloma virus (HPV), herpes simplex virus (HSV), (CT), and (NG), and associated risk factors among HIV-infected women in Fars province, Iran.

Materials And Methods: In this cross-sectional study, cervical swab samples were collected from 71 HIV-infected women, aged 17-45 years (mean ± standard deviation: 31. Read More

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Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease.

Authors:
Chris J Carter

J Alzheimers Dis Rep 2017 Sep 28;1(1):125-157. Epub 2017 Sep 28.

PolygenicPathways, Hastings, East Sussex, UK.

Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey showed that AD genome-wide association study (GWAS) genes (localized in bone marrow, immune locations and microglia) relate to multiple host/pathogen interactomes (, , Bornavirus, , cytomegalovirus, Ebola virus, HSV-1, HERV-W, HIV-1, Epstein-Barr, hepatitis C, influenza, , , ). These interactomes also relate to the AD hippocampal transcriptome and to plaque or tangle proteins. Read More

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September 2017
1 Read

The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible mechanisms, such as visceral hypersensitivity, irregular gut motility, abnormal brain-gut relations, and the role of infectious agents, are implicated in initiation and development of this syndrome. Read More

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November 2018
5 Reads

[Laboratory diagnosis of rare diseases].

Lakartidningen 2018 Nov 27;115. Epub 2018 Nov 27.

Klinisk kemi och Klinisk och experimentell medicin, Linköpings Universitet - Linköping , Sweden -.

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract which caters for a high predictive value in patients with symptoms and signs of community-acquired atypical pneumonias, provided optimal patient selection. Knowledge and awareness of treatable rare diseases amongst healthcare personnel combined with conveniently available cost-effective diagnostic techniques is essential for improvements in the handling of rare diseases. Read More

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November 2018
2 Reads

CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients.

Immunobiology 2018 Nov 20. Epub 2018 Nov 20.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Tropical Infectious Disease Research and Education Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Background: Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. Read More

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November 2018
1 Read

Prevalence of chlamydia trachomatis infection among reproductive age women in sub Saharan Africa: a systematic review and meta-analysis.

BMC Infect Dis 2018 Nov 26;18(1):596. Epub 2018 Nov 26.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Chlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, including Sub-Saharan Africa. There is nil systematic review and meta-analysis on Chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women. Therefore, this study was carried out to determine the pooled prevalence of chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women. Read More

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November 2018
3 Reads

Mint Flavorings from Candies Inhibit the Infectivity of Chlamydia pneumoniae.

Nat Prod Commun 2016 Nov;11(11):1725-1728

The impact of solvent extracts from the distillation water (flavoring extracts) isolated from mint flavored candies on the infectivity of the intracellular bacterium Chlamydia pneumoniae was evaluated by an in vitro model of epithelial cell infections., The mint flavoring extracts were isolated from the candies by simultaneous hydrodistillation and their chemical composition, established by GC-MS, demonstrated menthol and limonene as the most abundant components. Results obtained by treating C. Read More

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November 2016

Reaching key populations through key venues: Insights from the Jamaica HIV Prevention Program.

PLoS One 2018 26;13(11):e0206962. Epub 2018 Nov 26.

Department of Medicine, University of North Carolina, North Carolina, United States of America.

Introduction: HIV prevention strategies often include outreach to female sex workers at social venues identified as places where people meet new sexual partners. Patrons and staff at these venues may include female sex workers, their clients, as well as others who have high rates of new sexual partnerships. Few studies have compared HIV/STI among venue-based and general populations, across types of venues, or by sub-group of the venue population. Read More

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November 2018
5 Reads

Cervico-vaginal secretion cytokine profile: A non-invasive approach to study the endometrial receptivity in IVF cycles.

Am J Reprod Immunol 2018 Nov 26:e13064. Epub 2018 Nov 26.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Problem: Cytokines have a significant role in the process of embryo implantation, trophoblast growth, and differentiation by modulating the immune and endocrine system. The aim of this study was to investigate the profile of a large set of cytokines in the cervico-vaginal washing of women undergoing IVF, to explore the association of these proteins with a good receptive endometrium.

Method Of Study: A cohort of 155 women scheduled for IVF cycle was recruited. Read More

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November 2018
6 Reads

The prevalence of bacteriospermia in infertile men and association with semen quality in Southwestern Iran.

Infect Disord Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz. Iran.

Introduction: Infertility considered as a social and public health issue and estimated that the most of these infertile couple are residents of developing countries. Infectious diseases including the history of sexually transmitted infections (STIs) may impact on male reproductive function. Therefore, the present study aimed to investigate the prevalence of bacterial contaminants of semen and probable association with sperm quality of infertile men in Iranian population. Read More

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November 2018
3 Reads

An Integrated Care Model With Implementation Roadmap to Improve Management and Control in India.

Front Public Health 2018 9;6:321. Epub 2018 Nov 9.

Clinical Care and Research, Anova Health Institute, Johannesburg, South Africa.

is the world's most prevalent bacterial Sexually Transmitted infection (STI). It is associated with a wide range of health consequences and sequelae in both the short and long term. Enhanced control of urogenital infection is particularly important in low- and middle-income countries such as India, where most of the burden goes unnoticed and where limited systematic data is available to gauge the current situation. Read More

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November 2018

Chlamydia trachomatis Impairs Host Base Excision Repair by Downregulating Polymerase Beta.

Cell Microbiol 2018 Nov 24:e12986. Epub 2018 Nov 24.

Department of Microbiology, University of Wuerzburg Biocenter, Wuerzburg, Germany.

Chlamydia trachomatis infections have been associated with ovarian cancer by several epidemiological studies. Here, we show that C. trachomatis infected primary human ovarian epithelial cells display elevated oxidative DNA damage. Read More

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November 2018
3 Reads

A recombinant multi-epitope peptide vaccine based on MOMP and CPSIT_p6 protein protects against Chlamydia psittaci lung infection.

Appl Microbiol Biotechnol 2018 Nov 23. Epub 2018 Nov 23.

Institution of Pathogenic Biology, Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China.

Chlamydia psittaci is an obligate intracellular pathogen with a broad host range that can lead to severe infectious disease by transferring from birds to humans. Vaccination has been considered the best way to prevent chlamydial infection; nevertheless, there is currently still no commercially available vaccine that can inhibit the spread of C. psittaci. Read More

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November 2018
3 Reads

Epidemiology and current control of sexually transmitted infections. The role of STI clinics.

Enferm Infecc Microbiol Clin 2018 Nov 19. Epub 2018 Nov 19.

Servicio Enfermedades Infecciosas, OSI Bilbao-Basurto, Osakidetza, Grupo de estudio de ITS (GeITS) de la SEIMC, Instituto de Investigación Biocruces Bizkaia, Bizkaia, España. Electronic address:

The burden of disease from sexually transmitted infections (STI) undermines sexual and reproductive health and the health of newborn infants. The presence of some STI facilitates the transmission of others, such as HIV, and cause cellular changes that precede some types of cancer. For all these reasons STIs are a first order uncontrolled public health problem. Read More

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November 2018
5 Reads

Caution Is Required When Using Non-Food and Drug Administration-Cleared Assays to Diagnose Sexually Transmitted Infections in Children.

J Pediatr 2018 Nov 19. Epub 2018 Nov 19.

Department of Pediatrics, Division of Infectious Diseases, State University of New York, Downstate Medical Center, Brooklyn, NY.

Nucleic acid amplification testing is the gold-standard for Chlamydia trachomatis and Neisseria gonorrhoeae testing in adults. We present 3 pediatric cases in which testing resulted in probable false-positive results. Clinicians should avoid tests without clearance from a regulatory agency and should maintain consistent communication with laboratories. Read More

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November 2018
1 Read

Culture- and PCR-based detection of BV associated microbiological profile of the removed IUDs and correlation with the time period of IUD in place and the presence of the symptoms of genital tract infection.

Ann Clin Microbiol Antimicrob 2018 Nov 22;17(1):40. Epub 2018 Nov 22.

Institute of Clinical Microbiology, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, Semmelweis St. 6, Szeged, 6725, Hungary.

Objectives: The long-term use of intrauterine devices (IUDs) may lead to biofilm formation on the surface. The aim of this study was to perform the culture- and PCR-based detection of bacteria/fungi from the biofilm of the removed IUDs with different time periods in place.

Methods: For a 2-year period, 100 IUD users were involved in the study. Read More

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November 2018
4 Reads

Prevention of Chlamydia Infections With Theater in School Sex Education.

J Sch Nurs 2018 Nov 22:1059840518811912. Epub 2018 Nov 22.

2 Faculty of Medicine, School of Health Sciences, Örebro University, Örebro, Sweden.

The aim of the study was to evaluate if an intervention including theater in school sex education affects students' knowledge, attitudes, and behavior regarding condom use in Sweden. The study was a cluster randomized controlled trial. The intervention group got a play, value exercises, chlamydia games, condom school, and interactive replay with professional actors and staff from a youth guidance center. Read More

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November 2018

Prevalence of bacterial vaginosis and factors associated among women who have sex with women.

Rev Lat Am Enfermagem 2018 Nov 14;26:e3077. Epub 2018 Nov 14.

Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil.

Objective: to describe the prevalence of bacterial vaginosis and factors associated among women who have sex with women.

Method: cross-sectional, descriptive and analytical study with 150 women. The vaginal microbiota profile was analyzed by microscopic examination of vaginal swabs according to the Gram method. Read More

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November 2018
7 Reads

BC5 Interferes With Infectivity Through Integrin Modulation in Cervical Cells.

Front Microbiol 2018 6;9:2630. Epub 2018 Nov 6.

Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.

Lactobacilli play a crucial role in maintaining the ecological equilibrium of the vaginal niche, preventing the colonization of exogenous microorganisms. Although many studies have discussed the mechanisms displayed by lactobacilli in counteracting several urogenital pathogens, a few data are available on the interaction between lactobacilli and . This study aimed to elucidate the molecular bases of the interaction among vaginal lactobacilli, the sexually transmitted pathogen and the epithelial cervical cells. Read More

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November 2018
4 Reads

WHO laboratory validation of Xpert CT/NG and Xpert TV on the GeneXpert system verifies high performances.

APMIS 2018 Dec;126(12):907-912

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Effective tests for diagnosis of sexually transmitted infections (STIs), used point of care to inform treatment and management decisions, are urgently needed. We evaluated the analytical sensitivity and specificity of the Xpert CT/NG and Xpert TV tests, examining 339 samples spiked with phenotypically and/or genetically diverse strains of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis, and other related species that may cross-react. The APTIMA Combo 2 test and APTIMA TV test were used as reference tests. Read More

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December 2018
2 Reads

Schistosoma mansoni infection and socio-behavioural predictors of HIV risk: a cross-sectional study in women from Uganda.

BMC Infect Dis 2018 Nov 19;18(1):586. Epub 2018 Nov 19.

Department of Immunology, University of Toronto, Toronto, Canada.

Background: Schistosoma mansoni infection has been associated with increased risk of HIV transmission in African women. This association might be causal or mediated through shared socio-behavioural factors and associated co-infections. We tested the latter hypothesis in a cross-sectional pilot study in a cohort of women from a S. Read More

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November 2018
2 Reads

First Detection of Swedish' Variant (nvCT) in a Russian Couple with Infertility.

Open Microbiol J 2018 18;12:343-352. Epub 2018 Oct 18.

Department of Pathology & Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.

Background: Chronic asymptomatic chlamydial genital infection caused by the wild-type of (wtCT) is the most common bacterial infection causing human infertility. The novel 'Swedish' variant of (nvCT) which contains a 377 bp deletion in a region that is specifically targeted in some nucleic acid amplification tests may impede diagnosis.

Objective: The study aimed to investigate whether nvCT may be a possible cause of infertility in a couple undergoing fertilization (IVF). Read More

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October 2018
5 Reads

Identifying Syndemics for Sexually Transmitted Infections Among Young Adults in the United States: A Latent Class Analysis.

J Adolesc Health 2018 Nov 14. Epub 2018 Nov 14.

Department of Epidemiology and Biostatistics, College of Public Health, Temple University, Philadelphia, Pennsylvania. Electronic address:

Purpose: Syndemic theory suggests that the convergence of social, environmental, and ecological factors can interact to exacerbate behavioral health problems and are often intensified by social conditions and disparities. This study used latent class analysis (LCA) to determine gender and racial/ethnic specific classes for sexually transmitted infection (STI) risk.

Methods: LCA included 18 measured socioeconomic, depression, substance use, and sexual behavioral variables from 1,664 young adults ages 18-25 in the NHANES. Read More

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November 2018
7 Reads

Chlamydiae in human intestinal biopsy samples.

Pathog Dis 2018 Nov 1;76(8). Epub 2018 Nov 1.

Cantonal Hospital Winterthur, Brauerstrasse 15, CH-8400 Winterthur, Switzerland.

Chlamydia trachomatis is frequently detected in anorectal specimens from men and women. A recent hypothesis suggests that C. trachomatis is a natural commensal organism asymptomatically colonizing the gastrointestinal tract. Read More

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November 2018

High Frequency of MYD88 L265P Mutation in Primary Ocular Adnexal Marginal Zone Lymphoma and Its Clinicopathologic Correlation: A Study From a Single Institution.

Arch Pathol Lab Med 2018 Nov 16. Epub 2018 Nov 16.

From the Departments of Pathology (Drs Behdad, Gao, and Raparia; Mr Dittman; Drs Qi, Q Chen, and Y-H Chen) and Ophthalmology (Dr Bryar), Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Wayne State University School of Medicine, Detroit, Michigan (Dr Zhou); Research Resources Center, University of Illinois at Chicago, Chicago (Dr Green); Department of Pathology, University of Michigan, Ann Arbor (Dr Betz). Dr Zhou is currently at the Department of Ophthalmology, Bascom-Palmer Eye Institute, Miami, Florida. Dr Raparia is currently at the Department of Pathology, Kaiser Permanente, Santa Clara, California.

Context.—: The pathogenesis of primary ocular adnexal marginal zone lymphoma (POAMZL) remains unclear. The reported associations with Chlamydia psittaci infection and MYD88 mutations are highly variable. Read More

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November 2018

Chlamydia muridarum plasmid induces mouse oviduct pathology by promoting chlamydial survival and ascending infection and triggering host inflammation.

Eur J Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatovenereology, Tianjin Medical University General Hospital, Tianjin, China.

Background: Infection with plasmid-free Chlamydia trachomatis and Chlamydia muridarum fails to induce severe pathology, however, the mechanisms underlying this phenotype are unclear.

Objectives: To elucidate the mechanisms of chlamydial plasmid-mediated pathology in mouse oviducts.

Materials & Methods: BALB/c mice were intravaginally infected with either plasmid-competent or plasmid-free C. Read More

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November 2018

Associations between county-level voter turnout, county-level felony voter disenfranchisement, and sexually transmitted infections among women in the Southern United States.

Ann Epidemiol 2018 Oct 29. Epub 2018 Oct 29.

Institute for Global Health and Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Purpose: Voting may play a critical role in the allocation of social and structural resources to communities, which in turn shapes neighborhood environments, and ultimately, an individual's sexually transmitted infection (STI) risk. We assessed relationships among county-level voter turnout and felony voter disenfranchisement, and STIs.

Methods: This cross-sectional multilevel analysis included 666 women in Alabama, Florida, Georgia, Mississippi, and North Carolina enrolled in the Women's Interagency HIV Study between 2013 and 2015. Read More

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October 2018
2 Reads

P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation.

Immunobiology 2018 Nov 2. Epub 2018 Nov 2.

Immunobiology Program, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-902 Brazil. Electronic address:

The Gram-negative bacterium Porphyromonas gingivalis is strongly associated with periodontitis. We previously demonstrated that P2X7 receptor activation by extracellular ATP (eATP) triggers elimination of intracellular pathogens, such as Leishmania amazonensis, Toxoplasma gondii and Chlamydia trachomatis. We also showed that eATP-induced IL-1β secretion via the P2X7 receptor is impaired by P. Read More

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November 2018
2 Reads

Study protocol of the iMPaCT project: a longitudinal cohort study assessing psychological determinants, sexual behaviour and chlamydia (re)infections in heterosexual STI clinic visitors.

BMC Infect Dis 2018 Nov 13;18(1):559. Epub 2018 Nov 13.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Background: Chlamydia trachomatis (chlamydia), the most commonly reported sexually transmitted infection (STI) in the Netherlands, can lead to severe reproductive complications. Reasons for the sustained chlamydia prevalence in young individuals, even in countries with chlamydia screening programs, might be the asymptomatic nature of chlamydia infections, and high reinfection rates after treatment. When individuals are unaware of their infection, preventive behaviour or health-care seeking behaviour mostly depends on psychological determinants, such as risk perception. Read More

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November 2018
1 Read

The demographic and clinical profiles of women presenting with vaginal discharge syndrome at primary care facilities in South Africa: Associations with age and implications for management.

S Afr Med J 2018 Oct 2;108(10):876-880. Epub 2018 Oct 2.

Centre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg, South Africa; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Current South African guidelines for the management of vaginal discharge syndrome (VDS) do not recommend treatment for sexually transmitted infection (STI) pathogens for women aged ≥35 years whose partners do not have male urethritis syndrome. The guideline assumes that older women are unlikely to have an STI and that their partners do not have asymptomatic infections.

Objectives: To describe the demographic, behavioural and clinical characteristics of women with VDS, comparing older women (≥35 years) with younger women, and to determine the performance of age alone as a criterion for predicting the presence of STI. Read More

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October 2018
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Take three, test one: a cross-sectional study to evaluate the molecular detection of Chlamydia trachomatis and Neisseria gonorrhoeae in pooled pharyngeal, anorectal and urine samples versus single-site testing among men who have sex with men in Belgium.

Acta Clin Belg 2018 Nov 12:1-5. Epub 2018 Nov 12.

a HIV/STI Reference Laboratory, Department of Clinical Sciences , Institute of Tropical Medicine , Antwerp , Belgium.

Objectives: To investigate the efficacy of performing a pooling strategy of triple-anatomical site samples (pharyngeal, anorectal and urine samples) for simultaneous Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) nucleic acid amplification detection.

Methods: A total of 117 specimen sets (pharyngeal, anorectal and urine) were collected from 98 men between 2014 and 2016. Double sampling of pharyngeal, anorectal and urine samples allowed for pooled and unpooled analyses using a multiplex Abbott Real Time CT/NG assay, together with confirmatory PCR testing in case of CT/NG positivity. Read More

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November 2018

[Sexually transmitted infections and male fertility].

Hautarzt 2018 Dec;69(12):1006-1013

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Background: Sexually transmitted infections (STI) are common worldwide and can cause impairment of fertility. In women pelvic inflammatory disease with subsequent tubal sterility is well-documented but the influence of STI on male fertility is still controversely discussed OBJECTIVE: The effects of various bacterial and viral STI on male fertility are discussed.

Material And Methods: An evaluation of the international literature up to 30 April 2018 was carried out including studies on larger collectives from the Asiatic region. Read More

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December 2018
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Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human AntiC. trachomatis Antibodies.

mSphere 2018 Nov 7;3(6). Epub 2018 Nov 7.

Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.

Sensitive and specific detection of anti- antibodies in standard enzyme-linked immunosorbent assays (ELISAs) is compromised by cross-reactivity and poor sensitivity of classical antigens. Previously, we discovered 48 strongly reactive peptide antigens of -specific B-cell epitopes from 21 immunodominant proteins. By comprehensive individual testing of 11 top-ranked peptide antigens, we found very high sensitivity and specificity for detection of anti- antibodies in chemiluminescent ELISAs. Read More

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November 2018
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A retrospective seroepidemiologic survey of Chlamydia pneumoniae infection in patients in Beijing between 2008 and 2017.

PLoS One 2018 7;13(11):e0206995. Epub 2018 Nov 7.

Department of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Chlamydia pneumoniae (C. pneumoniae) is an obligate intracellular bacterium and a human pathogen that causes respiratory infectious diseases. More than 50% of the adult population worldwide was once infected with C. Read More

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November 2018
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