Int J Mol Sci 2021 Apr 9;22(8). Epub 2021 Apr 9.
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Several species of mycoplasmas, including , are associated with certain human cancers. We previously isolated and characterized in our laboratory a strain of human mycoplasma subtype (MF-I1) able to induce lymphoma in a Severe Combined Immuno-Deficient (SCID) mouse model, and we demonstrated that its chaperone protein, DnaK, binds and reduces functions of human poly-ADP ribose polymerase-1 (PARP1) and ubiquitin carboxyl-terminal hydrolase protein-10 (USP10), which are required for efficient DNA repair and proper p53 activities, respectively. We also showed that other bacteria associated with human cancers (including , , , , and ) have closely related DnaK proteins, indicating a potential common mechanism of cellular transformation. Read More