15,872 results match your criteria Chirurgia italiana[Journal]


Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.

There is a mechanistic link between the gut-derived metabolite trimethylamine-N-oxide (TMAO) and obesity-related diseases, suggesting that the TMAO pathway may also be linked to the pathogenesis of obesity. The Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction, and the Fatty Liver Index (FLI), a predictor of non-alcoholic fatty liver disease (NAFLD), are early predictors of metabolic syndrome (MetS). In this cross-sectional observational study, we investigated TMAO levels in adults stratified according to Body Mass Index (BMI) and the association of TMAO with VAI and FLI. Read More

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December 2018

Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy.

PLoS One 2018 14;13(12):e0208184. Epub 2018 Dec 14.

Dipartimento di Scienze Biomediche e Oncologia Umana, Università Aldo Moro di Bari, Bari, Italy.

Noroviruses are one of the leading causes of gastro-enteric diseases worldwide in all age groups. Novel epidemic noroviruses with GII.P16 polymerase and GII. Read More

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December 2018
1 Read

[Biological risk in agriculture and construction workplaces: a survey on perception, knowledge and prevention measures.]

G Ital Med Lav Ergon 2018 Dec;40(4):195-202

Cattedra di Igiene, Dipartimento di Medicina e Scienze per la Salute "Vincenzo Tiberio", Università degli Studi del Molise.

Objectives: Despite the potential presence in many workplaces, biological risk is little known and largely underestimated, except in healthcare environments. Objectives: To evaluate perception, knowledge and behaviors adopted for protection and prevention of biological risk, related also to the occupational activity, among construction and agricultural workers.

Methods: Workers were recruited at farms and construction companies of Molise Region, Central Italy, which were visited within the surveillance activities planned by local institutions. Read More

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December 2018

[Acute kidney injury as a risk marker for hospital readmission: a single-center pilot study in the general population of the Parma area].

G Ital Nefrol 2018 Dec;35(6)

Unità di Fisiopatologia dell'Insufficienza Renale Acuta e Cronica - Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma.

Acute Kidney Injury (AKI) is an important issue for the healthcare system, as it is associated with high mortality and increased risk of readmission, with consequent elevated healthcare resource utilization. We investigated the incidence of AKI based on the examination of the discharge cards of all patients admitted between January 1 2011 and December 31 2015 at the Parma University Hospital, as well as the frequency and type of 30-day hospital readmission in the patients discharged with a first AKI diagnosis (index admission). The mean pooled 5-year incidence of AKI was 2. Read More

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December 2018

Ten Years After Bariatric Surgery: Bad Quality of Life Promotes the Need of Psychological Interventions.

Front Psychol 2018 22;9:2282. Epub 2018 Nov 22.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

This study aims to evaluate long-term quality of life (QoL) and primary clinical outcomes, 10 years after biliointestinal bypass (BIB) surgery. It was expected that, although BIB might show encouraging primary outcomes, long term QoL could be significantly impaired. Ninety patients were contacted for a phone interview [age 41. Read More

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November 2018

Successful pregnancy after uterine artery embolization for uterine arterovenous malformation: a rare case report.

Int J Womens Health 2018 21;10:745-750. Epub 2018 Nov 21.

Università degli studi di Salerno - Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Salerno, Italy,

Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Read More

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November 2018

Anal Fistula Laser Closure: the length of fistula is the Achilles' heel.

Tech Coloproctol 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, ASS-5 Friuli Venezia Giulia, San Vito al Tagliamento, 33078, Italy.

Background: Laser closure is a novel sphincter-saving technique for the treatment of anal fistula. The aim of this study was to report middle term results of laser treatment without closure of the internal orifice and to identify prognostic factors to improve selection criteria and maximize healing.

Methods: A retrospective observational study was conducted on patients treated with laser for transphinteric anal fistula. Read More

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December 2018
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Octreotide SC depot in patients with acromegaly and functioning neuroendocrine tumors: a phase 2, multicenter study.

Cancer Chemother Pharmacol 2018 Dec 8. Epub 2018 Dec 8.

Endocrinology, DiMI and CEBR, University of Genoa, Genoa, Italy.

Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety of octreotide SC depot in patients with acromegaly and functioning NETs, previously treated with octreotide IM. Read More

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December 2018

Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.

Environ Res 2018 Nov 23;169:417-433. Epub 2018 Nov 23.

Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, Spain; Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Electronic address:

Background: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.

Objectives: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Read More

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November 2018

Ophthalmology in Chauliac's Chirurgia Magna, with a curious illustration.

Arch Soc Esp Oftalmol 2018 Dec 5. Epub 2018 Dec 5.

Servicio de Oftalmología, Hospital San Agustín, Avilés, Asturias, España.

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December 2018

[Types and frequencies of complications associated with midline catheters and PICCs in a South Tyrolean district hospital: a retrospective cohort study].

Pflege 2018 Dec 7:1-8. Epub 2018 Dec 7.

3 Landesfachhochschule für Gesundheitsberufe Claudiana, Bozen, Italien.

Types and frequencies of complications associated with midline catheters and PICCs in a South Tyrolean district hospital: a retrospective cohort study Abstract.

Background: Specialized registered nurses play a key role in the insertion and management of peripherally inserted central catheters (PICCs) and midline catheters in Anglo-Saxon countries. From the German-speaking area no data on the use of PICCs and midline catheters are available. Read More

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December 2018

Role of temperature and nutrients on the growth and toxin production of Prorocentrum hoffmannianum (Dinophyceae) from the Florida Keys.

Harmful Algae 2018 Dec 20;80:140-148. Epub 2018 Nov 20.

Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131, Ancona, Italy; Consorzio Interuniversitario per le Scienze del Mare, CoNISMa, ULR Ancona, Ancona, Italy.

The benthic dinoflagellate Prorocentrum hoffmannianum M.A. Faust is typical of tropical warm waters and produces biotoxins responsible for diarrhetic shellfish poisoning (DSP). Read More

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December 2018

Alcohol Pattern Consumption Differently Affects the Efficiency of Macrophage Reverse Cholesterol Transport in Vivo.

Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.

It has been well established that moderate alcohol consumption inversely correlates with cardiovascular morbidity and mortality, whereas binge alcohol drinking increases cardiovascular disease risk. The aim of this study was to assess in vivo the impact of different drinking patterns on reverse cholesterol transport (RCT); the atheroprotective process leading to the removal of excess cholesterol from the body. RCT was measured with a standardized, radioisotope-based technique in three groups of atherosclerosis-prone apolipoprotein E knock out mice: Placebo group, receiving water, which would mimic the abstainers; moderate group, receiving 0. Read More

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December 2018
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Impact of Nutritional Status on Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy.

Neuroendocrine tumors (NETs) are rare neoplasms mostly originating from the gastroenteropancreatic tract (GEP-NETs). Data regarding nutritional status in GEP-NET patients are limited. The aim of the study was to investigate the nutritional status and adherence to the Mediterranean Diet (MD) in GEP-NET patients and to correlate them with tumor aggressiveness. Read More

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December 2018

Applications of indocyanine green-enhanced fluorescence in laparoscopic colorectal resections.

Updates Surg 2018 Dec 3. Epub 2018 Dec 3.

Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy.

Recently, Indocyanine Green (ICG)-enhanced fluorescence has been introduced in laparoscopic colorectal surgery to provide detailed anatomical informations. The aim of our study is the application of ICG imaging during laparoscopic colorectal resections: to assess anastomotic perfusion to reduce the risk of anastomotic leak, to facilitate vascular dissection when vascular anatomy of tumor site is unclear, and to identify ureter to prevent iatrogenic injury. After the transection, 5 ml of ICG solution is intravenously injected. Read More

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December 2018
6 Reads

Microinvasive breast carcinoma: An analysis from ten Senonetwork Italia breast centres.

Eur J Surg Oncol 2018 Oct 16. Epub 2018 Oct 16.

Breast Unit, San Giovanni-Addolorata Hospital, Rome, Italy. Electronic address:

Background And Objectives: We studied a large series of ductal carcinoma in situ with microinvasion (MIDC) an infrequent disease whose diagnosis and management are not well defined.

Methods: 17,431 cases of breast carcinoma were treated between 2011 and 2016 by ten Italian Breast Units. Our analysis included diagnostic and clinic-pathological characteristics, surgical management, and the use of adjuvant therapies. Read More

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October 2018
2 Reads

VALIDATION OF A CLINICOPATHOLOGICALSCORE FOR THE PREDICTION OF POST-SURGICAL EVOLUTION OF PITUITARY ADENOMA: RETROSPECTIVE ANALYSIS ON 566 PATIENTS FROM A TERTIARY CARE CENTRE.

Eur J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

M Foschini, Department of Biomedical and Neuromotor Sciences (DIBINEM)-Surgical Pathology Section- Alma Mater Studiorum - University of Bologna, Universita degli Studi di Bologna Scuola di Medicina e Chirurgia, Bologna, Italy.

A clinicopathological score has been proposed by Trouillas et al. to predict the evolution of pituitary adenomas. Aim of our study was to perform an independent external validation of this score and identify other potential predictor of post-surgical outcome. Read More

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November 2018
1 Read

[Regeneration and rehabilitation. Plastic surgery practice in a rehabilitation centre.]

G Ital Med Lav Ergon 2018 Jun;40(2):97-105

Dipartimento di Medicina Molecolare, Università degli Studi di Pavia, Italia.

Objectives: Regenerative Surgery aims at the restoration of the loss of structures and functions of the body using four innovative approaches: physical energies, biomaterials, cell products and stem cells.

Methods: The Authors provide an overview of their experience with Regenerative Surgery procedures at the Plastic Surgery Unit of the University of Pavia, Istituti Clinici Scientifici Salvatore Maugeri, in a 10 years period, from 2007 to 2017, for the treatment of extensive acute soft tissue loss, chronic ulcers, disabling scars and degenerative pathologies with different aethiology.

Results: Regenerative Surgery is a well-established and effective practice in a modern Plastic Surgery Unit. Read More

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June 2018
1 Read

Long-term mortality in obese subjects undergoing malabsorptive surgery (biliopancreatic diversion and biliointestinal bypass) versus medical treatment.

Int J Obes (Lond) 2018 Nov 23. Epub 2018 Nov 23.

Ospedale San Paolo, Milan, Italy.

Background And Aim: Aim of this study was to analyze long-term mortality in obese patients receiving malabsorptive bariatric surgery (BS)[biliopancreatic diversion (BPD) and biliointestinal bypass (BIBP)] in comparison to medical treatment of obesity.

Patients And Methods: Medical records of 1877 obese patients [body mass index (BMI) > 35 kg/m, aged 18-65 years, undergoing BS (n = 472, 111 with diabetes) or non-surgical medical treatment (n = 1405, 385 with diabetes), during the period 1999-2008 (visit 1)] were collected; non-surgical patients were matched for age, sex, BMI, and blood pressure, and life status and causes of death were ascertained through December 2016. Survival was compared across surgery patients and non-surgical patients using Kaplan-Meier plots and Cox regression analyses. Read More

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November 2018
2 Reads

Treatment continuation and satisfaction in women using combined oral contraception with nomegestrol acetate and oestradiol: a multicentre, prospective cohort study (BOLERO).

Eur J Contracept Reprod Health Care 2018 Nov 22:1-7. Epub 2018 Nov 22.

k Facoltà di Medicina e Chirurgia Materno-Infantili e dell'Adulto , Università degli Studi di Modena e Reggio Emilia , Modena , Italy.

Objective: The aim of the study was to examine treatment continuation and satisfaction over 1 year among women receiving nomegestrol acetate (NOMAC)/oestradiol (E2) combined oral contraception (COC) in real-world clinical practice.

Methods: The 17β-Estradiol and Nomegestrol Acetate (BOLERO) Study is an observational, non-interventional, prospective, multicentre cohort study of premenopausal women (aged 18-50 years) who received prescription NOMAC/E2 (2.5 mg/1. Read More

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November 2018
8 Reads

Translation and cross-cultural adaptation of the Hypertension Knowledge-Level Scale for use in Brazil.

Rev Lat Am Enfermagem 2018 Nov 14;26:e3073. Epub 2018 Nov 14.

Hospital do Trabalhador, Unidade de Terapia Intensiva, Curitiba, PR, Brazil.

Objective: to make the translation, cross-cultural adaption and content and face validation of the Hypertension Knowledge-Level Scale for use in Brazil.

Methods: methodological research carried out in six stages: translation, synthesis, back-translation, expert committee's assessment, pre-test and validation. Validation was performed through the Delphi technique in two rounds. Read More

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November 2018

Exploring causality of the association between smoking and Parkinson's disease.

Int J Epidemiol 2018 Nov 20. Epub 2018 Nov 20.

School of Public Health, Imperial College London, London, UK.

Background: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality or an unmeasured confounding related to a low-risk-taking personality trait.

Methods: A total of 715 incident PD cases were ascertained in a cohort of 220 494 individuals from NeuroEPIC4PD, a prospective European population-based cohort study including 13 centres in eight countries. Read More

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November 2018
5 Reads

A Rapid Procedure for Identification and Antifungal Susceptibility Testing of Yeasts From Positive Blood Cultures.

Front Microbiol 2018 15;9:2400. Epub 2018 Oct 15.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, Italy.

The development of rapid diagnostic assays for the identification and analysis of antimicrobial resistance of fungal pathogens causing invasive mycoses is of utmost importance to reduce morbidity and mortality. We evaluated the performance of a novel rapid procedure directly applied to monomicrobial blood cultures from patients with bloodstream infection caused by yeast species, including nine and three non- species. For the rapid procedure herein developed, samples of positive blood cultures were transferred into serum separator tubes and treated with sodium dodecyl sulfate; the yeast layer was recovered and directly used for microbial identification by MALDI-TOF mass spectrometry and antifungal susceptibility testing (AFST) by the Sensititre YeastOne Y010 panel. Read More

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October 2018
2 Reads

Adrenal cavernous hemangioma: a case report.

BMC Surg 2018 Nov 20;18(1):103. Epub 2018 Nov 20.

Department of Clinical and Experimental Medicine, Unit of General Surgery 2, University of Sassari, Sassari, Italy.

Background: Adrenal cavernous hemangiomas are very rare benign tumors that usually present as incidental findings on abdominal imaging. Preoperative differential diagnosis from other benign or malignant adrenal neoplasms may be challenging.

Case Presentation: A 70-year old man was referred for an 8-cm abdominal mass incidentally discovered on a contrast-enhanced computed tomography (CT) performed to investigate a pulmonary nodule. Read More

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November 2018
4 Reads

Editorial: Redox and Nitrosative Signaling in Cardiovascular System: From Physiological Response to Disease.

Front Physiol 2018 2;9:1538. Epub 2018 Nov 2.

Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Turin, Italy.

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November 2018

Incidence of Diabetes Mellitus, Cardiovascular Diseases, and Cancer in Patients Undergoing Malabsorptive Surgery (Biliopancreatic Diversion and Biliointestinal Bypass) vs Medical Treatment.

Obes Surg 2018 Nov 17. Epub 2018 Nov 17.

Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.

Background And Aims: Bariatric surgeries such as gastric banding (LAGB), gastric bypass (RYGB), vertical banded gastroplasty (VBG), and sleeve gastrectomy (LSG) decrease body weight in morbid obesity, leading to the resolution of coexisting diabetes mellitus and arterial hypertension in the majority of cases as well as improvements of renal function and liver steatosis. BS (LAGB, RYGB, VBG, and LSG) also reduce incident cases of diabetes, of cardiovascular diseases, and of cancer; these therapeutic and preventive effects on comorbidities of obesity have not been analyzed for malabsorptive surgeries such as biliopancreatic diversion (BPD) or biliointestinal bypass (BIBP). The aim of this study was to analyze the incidence of comorbidities, i. Read More

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November 2018
2 Reads

Headache attributed to aeroplane travel: the first multicentric survey in a paediatric population affected by primary headaches.

J Headache Pain 2018 Nov 14;19(1):108. Epub 2018 Nov 14.

Juvenile Headache Centre, University of Padua, via Giustiniani 3, 35128, Padua, Italy.

Background: This multicentric survey investigates the prevalence and characteristics of Airplane Headache in children affected by primary headaches.

Methods: Patients with symptoms of Airplane Headache were recruited from nine Italian Pediatric Headache Centres. Each patient was handed a structured questionnaire which met the ICHD-III criteria. Read More

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November 2018
2 Reads
2.800 Impact Factor

Stanozolol promotes osteogenic gene expression and apposition of bone mineral in vitro.

J Appl Oral Sci 2018 Nov 8;27:e20180014. Epub 2018 Nov 8.

Università degli Studi di Parma, Dipartimento di Medicina e Chirurgia, Unità di Patologia Generale, Parma. Italy.

Stanozolol (ST) is a synthetic androgen with high anabolic potential. Although it is known that androgens play a positive role in bone metabolism, ST action on bone cells has not been sufficiently tested to support its clinical use for bone augmentation procedures.

Objective: This study aimed to assess the effects of ST on osteogenic activity and gene expression in SaOS-2 cells. Read More

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November 2018
5 Reads

MALDI-TOF MS Applications to the Detection of Antifungal Resistance: State of the Art and Future Perspectives.

Front Microbiol 2018 30;9:2577. Epub 2018 Oct 30.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, Italy.

MALDI-TOF MS technology has made possible revolutionary advances in the diagnosis of infectious diseases. Besides allowing rapid and reliable identification of bacteria and fungi, this technology has been recently applied to the detection of antimicrobial resistance. Several approaches have been proposed and evaluated for application of MALDI-TOF MS to antimicrobial susceptibility testing of bacteria, and some of these have been or might be applied also to yeasts. Read More

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October 2018
7 Reads

The T197A knock-in model of Cdkn1b gene to study the effects of p27 restoration in vivo.

Mol Cancer Ther 2018 Nov 13. Epub 2018 Nov 13.

Experimental and Clinical Medicine, University Magna Graecia of Catanzaro

The CDK inhibitor, p27kip1, encoded by the Cdkn1b gene can negatively modulate cell proliferation. The control of p27 activity during the cell cycle is regulated at multiple levels including transcription, translation and protein stability. The last residue of p27 (threonine 198 in human, threonine 197 in mouse) is involved in the control of protein stability. Read More

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November 2018
8 Reads

Role of apparent diffusion coefficient values in prostate diseases characterization on diffusion-weighted magnetic resonance imaging.

Minerva Urol Nefrol 2018 Nov 7. Epub 2018 Nov 7.

Sezione di Scienze Radiologiche, Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli Studi di Palermo, Palermo, Italy.

Background: To evaluate if normal and pathological prostate tissue can be distinguished by using apparent diffusion coefficient (ADC) values on magnetic resonance imaging (MRI) and to understand if it is possible to differentiate among pathological prostate tissues using ADC values.

Methods: Our population consisted in 81 patients (mean age 65.4) in which 84 suspicious areas were identified. Read More

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November 2018
10 Reads

Recurrence of Hepatitis B Infection in Liver Transplant Patients Receiving Long-Term Hepatitis B Immunoglobulin Prophylaxis.

Ann Transplant 2018 Nov 13;23:789-801. Epub 2018 Nov 13.

Transplant Centre, Faculty of Medicine, Azienda Ospedaliera Policlinico Tor Vergata, Rome, Italy.

BACKGROUND Long-term real-world data are relatively sparse regarding recurrence of chronic hepatitis B virus (HBV) infection after liver transplantation using hepatitis B immunoglobulin (HBIg) and nucleos(t)ide analogue (NUC) prophylaxis. MATERIAL AND METHODS Data from 371 adults transplanted for HBV-related disease at 20 European centers and given HBIg for ³12 months ± NUC therapy were analyzed retrospectively. RESULTS HBIg comprised Hepatect® (iv HBIgB; n=299), subcutaneous Zutectra® (sc HBIg, n=236), and other HBIg preparations (n=130); 93. Read More

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November 2018
13 Reads

Association of plasma vitamin D metabolites with incident type 2 diabetes: EPIC-InterAct case-cohort study.

J Clin Endocrinol Metab 2018 Nov 9. Epub 2018 Nov 9.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Background: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: non-epimeric and epimeric 25(OH)D3 stereoisomers; and 25(OH)D2, the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating levels of the sum and each of these three metabolites with incident T2D.

Methods: This analysis in the EPIC-InterAct case-cohort study for T2D included 9671 incident T2D cases and 13562 subcohort members. Read More

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November 2018
1 Read

The Neuroprotective Effects of 17β-Estradiol Pretreatment in a Model of Neonatal Hippocampal Injury Induced by Trimethyltin.

Front Cell Neurosci 2018 26;12:385. Epub 2018 Oct 26.

Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Rome, Italy.

Hippocampal dysfunction plays a central role in neurodevelopmental disorders, resulting in severe impairment of cognitive abilities, including memory and learning. On this basis, developmental studies represent an important tool both to understanding the cellular and molecular phenomena underlying early hippocampal damage and to study possible therapeutic interventions, that may modify the progression of neuronal death. Given the modulatory role played by 17β-estradiol (E2) on hippocampal functions and its neuroprotective properties, the present study investigates the effects of pretreatment with E2 in a model of neonatal hippocampal injury obtained by trimethyltin (TMT) administration, characterized by neuronal loss in CA1 and CA3 subfields and astroglial and microglial activation. Read More

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October 2018
3 Reads

Sport, doping and male fertility.

Reprod Biol Endocrinol 2018 Nov 12;16(1):114. Epub 2018 Nov 12.

Department of Movement, Human and Health Sciences, Unit of Endocrinology, Università degli Studi di Roma "Foro Italico", Largo Lauro de Bosis 15, 00135, Rome, Italy.

It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nutrition and sedentary behavior, is suggested in order to preserve/improve fertility in humans. However, the possible risks of physical exercise per se or sports on male fertility are less known. Read More

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November 2018
4 Reads

Sentinel lymph node biopsy in porocarcinoma: A case reports.

Int J Surg Case Rep 2018 Oct 31;53:196-199. Epub 2018 Oct 31.

Department of Surgery, Chirurgia I- Ospedale Policlinico San Martino Genoa, Italy.

Introduction: Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both. Histological examination is essential to formulate a correct diagnosis. Read More

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October 2018
4 Reads

A 9 years comparison of weight loss, disappearance of obesity, and resolution of diabetes mellitus with biliointestinal bypass and with adjustable gastric banding: experience of a collaborative network.

Acta Diabetol 2018 Nov 9. Epub 2018 Nov 9.

Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.

Aims: Long-term comparisons between bariatric surgical techniques have been performed for gastric bypass (RYGB), sleeve gastrectomy (LSG), and biliopancreatic diversion (BPD) vs gastric banding (LAGB), but short-term studies (6 months-4 years) have only compared biliointestinal bypass (BIBP) and LAGB. The participating institutions regularly perform both BIBP and LAGB with a common protocol, and the aim of this retrospective study was to compare long-term effects of the two procedures on body weight, on clinical and metabolic variables, and on resolution of obesity and of diabetes.

Methods: All procedures performed between 01/01/1998 and 31/12/2005 were considered; 73 out of 91 patients undergoing BIBP, and 154 out of 249 patients undergoing LAGB were evaluable up to 9 years. Read More

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November 2018
3 Reads

Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite.

Chemosphere 2019 Jan 18;215:870-880. Epub 2018 Oct 18.

Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Electronic address:

Bisphenol AF (BPAF) is a fluorinated analog of bisphenol A (BPA), and it is a more potent estrogen receptor (ER) agonist. BPAF is mainly metabolized to BPAF-glucuronide (BPAF-G), which has been reported to lack ER agonist activity and is believed to be biologically inactive. The main goal of the current study was to examine the influence of the metabolism of BPAF via glucuronidation on its ER activity and adipogenesis. Read More

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January 2019
1 Read

Immunotherapy failure in adrenocortical cancer: where next?

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

A Berruti, Universita degli Studi di Brescia Aree Disciplinari Medicina e Chirurgia, Brescia, Italy.

Excerpt: Adrenocortical carcinoma (ACC) is a rare endocrine neoplasia, characterized by an overall dismal prognosis and its clinical manifestations are the consequence of either steroid excess or tumor mass progression. Surgery is the mainstay of therapy. For patients with locally advanced or metastatic ACC, not amenable to surgery, Mitotane and cytotoxic chemotherapy (with etoposide, doxorubicin and cisplatin - EDP scheme) are the systemic treatments currently in use. Read More

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November 2018
5 Reads

Does muscular activity related to vertical facial divergence influence the time needed for orthodontic extrusion of palatally impacted maxillary canines? A retrospective study.

J Clin Exp Dent 2018 Sep 1;10(9):e869-e875. Epub 2018 Sep 1.

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.

Background: The aim of the present study was to evaluate if the different muscular activity correlated to different degrees of facial divergence has an effect on the time needed to extrude a palatally impacted maxillary canine.

Material And Methods: Twenty-six patients were retrospectively selected, all treated with a specific cantilever appliance that allows extrusion of the impacted canine applying a physiologic amount of force below 0.6 N in a predictable way. Read More

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September 2018
1 Read

Reply to the Letter to the Editor: Comment to Jejunal Diverticulitis Mimicking Small Bowel Perforation: Case Report and Review of the Literature.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):720-721

Dear Editor, We thank the authors of this letter to the editor for the valuable information that they provided. We are familiar to the fact that conservative management is gaining ground against surgical treatment and this fact is mentioned in our article. This fact is better highlighted through the references that the authors of the letter to the editor provided and their comments. Read More

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October 2018
2 Reads

Comment to Jejunal Diverticulitis Mimicking Small Bowel Perforation: Case Report and Review of the Literature.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):719

Dear Editor, I would like to congratulate the authors of this well written article and to thank them for the contribution to the literature. There is, however, one point that needs to be addressed, and that is the outcomes of surgical versus conservative treatment. Areview article1 has published data on 266 patients (106 patients derived from published case reports containing individual patient data, 113 patients derived from the Norwegian patient registry and data on 47 patients as historical controls from a previous publication and used as historical controls(Chendrasekhar et al2). Read More

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October 2018
2 Reads

Breast Metastasis as a Presentation of Malignant Melanoma.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):712-718

The majority of malignant breast lesions are primary tumors originated from breast tissue. These primary breast cancers usually metastasize to lymph nodes, lungs, bones and brain. Metastases from cancers of other organs to the breast are very rare, but have been encountered in patients with malignant melanoma, carcinoid tumors or lung carcinoma. Read More

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October 2018
3 Reads

Laparoscopic Biliopancreatic Diversion with Duodenal Switch - The Most Effective Operation for Type 2 Diabetes Mellitus. How I do it?

Chirurgia (Bucur) 2018 Sept-Oct;113(5):704-711

Morbid obesity and type 2 diabetes are rapidly increasing worldwide. The conservative treatment is providing a limited control while the more efficient metabolic surgery is more recommended. Biliopancreatic diversion with duodenal switch (BPD-DS) is the operation which provides one of the most stable weight losses and T2DM remission of any bariatric procedure. Read More

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October 2018
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Parietal Endometriosis: A Challenge for the General Surgeon.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):695-703

Parietal endometriosis (PE) is a rare pathology, which usually develops in fertile women, after surgical or gynecological procedures. Its quasi-pathognomonic symptomatology consists in catamenial pain with or without palpable mass. The diagnosis can be challenging because it may be confused with stitch granuloma, hematoma, hernia or even cancer. Read More

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October 2018
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Tumor is an Oxidative Stress Factor in Ovarian Cancer Patients.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):687-694

Epithelial ovarian cancer is worldwide the second cause of gynaecological cancer but the commonest cause of gynaecological cancer-associated death.

Aim: To determine the intensity of oxidative stress in ovarian cancer patients and to establish a connection between the presence of the tumor and reactive oxygen species (ROS).

Patients And Methods: Thirty-five patients diagnosed with epithelial ovarian carcinoma stage II-IV between 2010 and 2017, who underwent multimodality treatment (surgery and chemotherapy) were included in the study. Read More

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October 2018
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Sarcopenia is a Predictive Factor for Postoperative Morbidity and Mortality in Patients Having Radical Gastrectomy for Cancer.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):678-686

Patients with gastric cancer are frequently malnourished with 30% to 38% of them losing more than 10% of their weight in preceding six months. Sarcopenia represents a decrease in the skeletal muscle mass and function and is usually associated with the aging process. The prevalence of sarcopenia in patients with gastric cancer is reported to be as high as 57. Read More

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October 2018
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Surgical Revascularization in Chronic Limb-threatening Ischemia in Diabetic Patients.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):668-677

Diabetes mellitus is one of the chronic diseases that showed a steady increase in the number of patients in the last decades. After the diagnosis of diabetes mellitus, evolution towards limb amputation goes, step by step, through neuropathy, leg ulcers and infection appearance. The existence of diabetic arteriopathy prevents ulcer's healing due to the limb's ischemic status. Read More

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October 2018
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Soft Tissue Infections in Diabetic Patients.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):651-667

the patient with diabetes has an increased susceptibility to infections, with negative evolutionary potential leading to increased morbidity and mortality compared to the general population. The cause is the alteration of immune defense mechanisms, the hyperglycemic environment leading to alteration of neutrophil function, suppression of the antioxidant system and humoral activity, systemic micro and macroangiopathy, neuropathy, depression of antibacterial activity of the genitourinary and digestive tract. Infections localized at the soft tissue (skin, fascia and aponeurosis, subcutaneous tissue, muscles) in the diabetic patient require a complex medico-surgical approach in which aggressive surgical treatment should be complemented by metabolic balancing and sustained antibiotic therapy. Read More

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October 2018
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Skin Grafting in the Treatment of Diabetic Foot Soft Tissue Defects.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):644-650

According to the World Health Organization, cases of diabetes have risen from 108 million in 1980 to 422 million in 2014, with a more rapid rising in middle- and low-income countries. Diabetes causes yearly approximately 1.6 million deaths, and is a major cause of heart attacks, stroke, kidney failure, blindness and lower limb amputation. Read More

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October 2018
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