840,425 results match your criteria Chinese medical sciences journal = Chung-kuo i hsueh k\'o hsueh tsa chih[Journal]


Chemical Components and Antibacterial Activity of the Essential Oil of Six Pyrrosia Species.

Chem Biodivers 2020 Jul 11. Epub 2020 Jul 11.

Shandng Drug and Food Vocational College, School of Pharmacy, East Chuzhang Road, New City of Science and Technology, Weihai High-tech Industrial Development Zone, Weihai city, CHINA.

The present study was aimed at analyzing the chemical components of the essential oil from six Pyrrosia species by GC-MS and evaluate their in vitro antibacterial activities. Seventy volatile compounds were identified in the essential oil of six Pyrrosia samples. The identified volatile components were divided into the following nine categories: aldehydes, terpenoids, fatty acids, ketone, furans, hydrocarbons, alcohols, esters, and phenols. Read More

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http://dx.doi.org/10.1002/cbdv.202000526DOI Listing

Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature.

Mol Genet Genomic Med 2020 Jul 11:e1396. Epub 2020 Jul 11.

Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: Minichromosome maintenance complex component 8 (MCM8) is responsible for homologous recombination and DNA double-strand breaks (DSBs) repair and is the cause of primary ovarian insufficiency (POI), which is seldom diagnosed in adolescents and children.

Methods: Whole-exome sequencing was performed in a 13-year-old girl, and Sanger sequencing was used to identify potentially pathogenic variants in her sister (aged 6 years and 7 months) and parents. To identify potential pathogenic mutations, DSBs were induced by mitomycin C (MMC), and the DNA repair capacity was evaluated by the histone H2AX phosphorylation level. Read More

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http://dx.doi.org/10.1002/mgg3.1396DOI Listing

Improving timely treatment with a stroke emergency map: The case of northern China.

Brain Behav 2020 Jul 11:e01743. Epub 2020 Jul 11.

Department of Neurology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China.

Objective: The Chinese stroke emergency map (SEM) was implemented in 2017 to reduce prehospital and hospital delays for acute ischemic stroke (AIS) patients suitable for intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis. However, data on the time delay following the implementation of an SEM in China are limited.

Methods: Data for suspected stroke patients from the SEM registry center of Taiyuan, Shanxi Province, from August 2017 to July 2019, patients' characteristics, thrombolysis rate, and functional outcome at 90 days were analyzed. Read More

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http://dx.doi.org/10.1002/brb3.1743DOI Listing

A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology.

Clin Transl Med 2020 Jul 11. Epub 2020 Jul 11.

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

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http://dx.doi.org/10.1002/ctm2.50DOI Listing

SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.

J Cell Mol Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with the Shanghai Jiaotong University School of Medicine, Shanghai, China.

Numerous single nucleotide polymorphisms (SNPs), which have been identified as susceptibility factors for Parkinson's disease (PD) as per genome-wide association studies, have not been fully characterized for PD patients in China. This study aimed to replicate the relationship between 12 novel SNPs of 12 genes and PD risk in southern Chinese population. Twelve SNPs of 12 genes were detected in 231 PD patients and 249 controls, using the SNaPshot technique. Read More

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http://dx.doi.org/10.1111/jcmm.15508DOI Listing

Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects.

Glia 2020 Jul 11. Epub 2020 Jul 11.

School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China.

Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN-γ was administered to mice via intracerebroventricular injection. Read More

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http://dx.doi.org/10.1002/glia.23878DOI Listing

The response of soil respiration to precipitation change is asymmetric and differs between grasslands and forests.

Glob Chang Biol 2020 Jul 11. Epub 2020 Jul 11.

Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.

Intensification of the Earth's hydrological cycle amplifies the interannual variability of precipitation, which will significantly impact on terrestrial carbon (C) cycle. However, it is still unknown whether previously observed relationship between soil respiration (R ) and precipitation remains applicable under extreme precipitation change. By analyzing the observations from a much larger dataset of field experiments (248 published papers including 151 grassland studies and 97 forest studies) across a wider range of precipitation-manipulation than previous studies, we found that the R response to precipitation change was highly nonlinear or asymmetric, and differed significantly between grasslands and forests, between moderate and extreme precipitation changes. Read More

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http://dx.doi.org/10.1111/gcb.15270DOI Listing

Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

It is known that social stress could alter oxytocin (OT) and arginine-vasopressin (AVP) expression in specific regions of brains which regulate the aggressive behavior of small rodents, but the effects of density-induced social stress are still unknown. Brandt's voles (Lasiopodomys brandtii) is a small herbivores in the grassland of China, but the underlying neurological mechanism of population regulation is still unknown. We tested the effects of housing density of Brandt's voles on OT/AVP system with physical contact (allowing aggression) and without physical contact (not allowing aggression) under laboratory conditionunder laboratory conditions. Read More

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http://dx.doi.org/10.1111/1749-4877.12467DOI Listing

Identification and genetic characterization of Contracaecum sp. (Nematoda Anisakidae) from China.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Contracaecum species are economically important fish-borne larval nematodes with zoonotic significance. In June 2019, more than one hundred piscivorous birds were died in its habitats close to the Wild Duck Lake, located in Yanqing, northwest of Beijing, China. Post-mortem examination of Black Night Herons (Nycticorax) revealed the presence of numerous anisakid nematodes in the proventriculus. Read More

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http://dx.doi.org/10.1111/1749-4877.12465DOI Listing

Phylogenetic analysis and expression differences of eye-related genes in cavefish genus Sinocyclocheilus.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Membrane Biology, Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

The adaptive evolution of visual systems has been observed in many cavefish. However, little is known about the molecular mechanisms underlying these adaptations, which include regressive changes such as eye degeneration. Here, we analyzed phylogenetic and expression patterns of six eye-related genes (crx, foxg1b, opn1sw2, otx2, rho, and sox2) in twelve Sinocyclocheilus species from China including eight stygobionts and four stygophiles, and examined photoreceptor cell morphology of these species. Read More

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http://dx.doi.org/10.1111/1749-4877.12466DOI Listing

MicroRNA-142 regulates osteoblast differentiation and apoptosis of mouse pre-osteoblast cells by targeting bone morphogenetic protein 2.

FEBS Open Bio 2020 Jul 11. Epub 2020 Jul 11.

Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong Province, 261041, P. R. China.

Osteoporosis is a common disease that can seriously impair the physical and mental health of the elderly. However, current treatment is unsatisfactory, due to the lack of effective therapeutic targets. Abnormal expression and involvement of microRNA-142 (miR-142) have been identified in many diseases, including bone-related diseases. Read More

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http://dx.doi.org/10.1002/2211-5463.12929DOI Listing

Astroglial N-myc downstream-regulated gene 2 protects the brain from cerebral edema induced by stroke.

Glia 2020 Jul 11. Epub 2020 Jul 11.

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Air Force Military Medical University, Xi'an, China.

Brain edema is a grave complication of brain ischemia and is the main cause of herniation and death. Although astrocytic swelling is the main contributor to cytotoxic edema, the molecular mechanism involved in this process remains elusive. N-myc downstream-regulated gene 2 (NDRG2), a well-studied tumor suppressor gene, is mainly expressed in astrocytes in mammalian brains. Read More

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http://dx.doi.org/10.1002/glia.23888DOI Listing

Surgical results and pathological analysis of cardiac fibroma in the adolescent and the adult.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Backgrounds: Disparities may exist between the adolescent and the adult patients with cardiac fibromas in the symptoms, surgical outcomes, and pathological characteristics. The aim of this study was to compare short and midterm surgical outcomes of cardiac fibromas and to compare the biomarker expressions of tumor tissue samples between the adult and the adolescent.

Methods: Consecutive patients with the diagnosis of cardiac fibroma were admitted and received surgeries. Read More

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http://dx.doi.org/10.1111/jocs.14790DOI Listing

Mouse Double Minute 2 Amplification in Esophageal Squamous Cell Carcinoma Associated with Better Outcome.

Histopathology 2020 Jul 11. Epub 2020 Jul 11.

Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.

Aims: This study aimed to determine the frequency of mouse double minute 2 (MDM2) amplification in esophageal squamous cell carcinomas (ESCC) and to clarify its prognostic significance.

Methods: We investigated MDM2 amplification on tissue microarrays, using fluorescence in situ hybridization and analyzed its correlations with clinicopathological features and outcomes in 515 Chinese ESCC patients.

Results: MDM2 amplifications were found in 37 of 515 ESCC patients (7. Read More

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http://dx.doi.org/10.1111/his.14208DOI Listing

Successful resection of a huge schwannoma of the aortic root with 5-years follow-up.

Authors:
Zhixiong Huang

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Surgery, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China.

Primary benign schwannomas of the heart are very rare. We report the case of a patient with a huge schwannoma of unique aortic origin. The complete resection of the rare tumor has been successfully performed. Read More

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http://dx.doi.org/10.1111/jocs.14797DOI Listing

Type A aortic dissection in the East and West: A comparative study between two hospitals from China and the US.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: In this study, we compare the clinical characteristics, intraoperative management, and postoperative outcomes of patients with acute type A aortic dissection (ATAAD) between two academic medical hospitals in the United States and China.

Methods: From January 2011 to December 2017, 641 and 150 patients from Nanjing Drum Tower Hospital (NDTH) and Massachusetts General Hospital (MGH) were enrolled. Patient demographics, clinical features, surgical techniques, and postoperative outcomes were compared. Read More

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http://dx.doi.org/10.1111/jocs.14766DOI Listing

The E3 ubiquitin ligase Itch deficiency promotes antigen-driven B-cell responses in mice.

Eur J Immunol 2020 Jul 11. Epub 2020 Jul 11.

Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.

Deficiency of Itch, an E3 ubiquitin ligase, usually induced severe systemic and progressive autoimmune disease. The Itch function is well-studied in T cells but not in B cells. We hypothesize that B-cell-specific Itch deficiency promoted antigen-induced B-cell activation and antibody-expressing plasma cell (PC) production. Read More

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http://dx.doi.org/10.1002/eji.202048640DOI Listing

polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice.

Aging (Albany NY) 2020 Jul 11;12. Epub 2020 Jul 11.

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Polysaccharides (CPPs), a traditional Chinese medicine used for thousands of years, is a potential neuroprotective polysaccharide via a relatively poorly understood mechanism. We previously reported that CPPs attenuated tau pathology in hTau transfected mice and therefore in the current work investigated the effect of CPPs on Aβ toxicity and cognitive defects in APP/PS1 mice model. It was found that one-month intragastric administration of CPPs significantly ameliorated cognitive defects in APP/PS1 mice. Read More

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http://dx.doi.org/10.18632/aging.103445DOI Listing

A model based on tumor-infiltrating immune cells for predicting the relapse rates of patients with testicular germ cell tumors.

Int Immunopharmacol 2020 Jul 8;86:106710. Epub 2020 Jul 8.

Department of Urology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. Electronic address:

Objective: The activities of tumor-infiltrating immune cells (TIICs) play an important role in the outcomes of many types of cancers. Here, we sought to describe the landscape of TIICs in testicular germ cell tumors (TGCT) and to develop a prognostic model based on this information.

Methods: The Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm was used to determine the proportions of 22 types of TIICs in a TGCT dataset (n = 74). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106710DOI Listing

Recommendations for coronavirus disease 2019 (COVID-19) prevention and infection control in the radiology department: Chinese experience.

Clin Imaging 2020 Jul 1;69:33-36. Epub 2020 Jul 1.

Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong, People's Republic of China; Quality Control Center of Radiology in Guangdong Province, No. 123 Huifu Road West, Guangzhou 510180, Guangdong, People's Republic of China. Electronic address:

The coronavirus disease 2019 (COVID-19) outbreak, first reported in Wuhan, China, is gradually spreading worldwide. For diagnosis, chest computed tomography is a conventional, noninvasive imaging modality that is very accurate for detection and evaluation of pneumonia and is an important adjunct to real-time reverse transcription polymerase chain reaction diagnosis of the virus. Previous studies have reported typical computed tomography imaging features indicative of COVID-19, such as multifocal ground-glass opacities with or without consolidation. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.044DOI Listing

Chest CT imaging features and clinical outcome of coronavirus disease 2019 (COVID-19): A single-center case study in Ningbo, China.

Clin Imaging 2020 May 30;69:27-32. Epub 2020 May 30.

Department of Radiology, Ningbo First Hospital, Ningbo, Zhejiang 315010, China; Department of Nuclear Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315010, China. Electronic address:

Objective: The purpose of this study was to investigate the chest CT imaging features and clinical outcome of coronavirus disease 2019 (COVID-19) in Ningbo, China.

Methods: In this retrospective study, twenty-eight confirmed and seven highly suspected cases of COVID-19 were enrolled in Ningbo first hospital from January 26, 2020 to March 5, 2020. Cases were confirmed by real-time polymerase chain reaction (RT-PCR). Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.05.028DOI Listing

Response of antibiotic resistance genes in constructed wetlands during treatment of livestock wastewater with different exogenous inducers: Antibiotic and antibiotic-resistant bacteria.

Bioresour Technol 2020 Jul 6;314:123779. Epub 2020 Jul 6.

Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China. Electronic address:

This work aimed to study the behavior of antibiotic resistance genes (ARGs) in constructed wetlands with different exogenous inducers additions (oxytetracycline and its resistant bacteria) by high-throughput quantitative polymerase chain reaction. Results indicated that constructed wetlands have the potential to reduce ARGs relative abundances in wastewater, and the total ARGs removal efficiency could exceed 60%. ARGs profile in the effluent differed from that in the influent, and that did not directly reflect the export of dominant ARGs in wetland biofilms. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123779DOI Listing

Microwave assisted flocculation for harvesting of Chlorella vulgaris.

Bioresour Technol 2020 Jul 2;314:123770. Epub 2020 Jul 2.

Department of Bioproducts and Biosystems Engineering, University of Minnesota-Twin Cities, Saint Paul, MN 55108, USA. Electronic address:

Microalgae harvesting is a major hindrance for the development of the microalgae industry. In this paper, short microwave treatment was used to assist the flocculation of Chlorella vulgaris with three flocculants, Fe (FeCl), chitosan, and Ca (CaCl). A microwave irradiation time of 20 s, and a pH of 10 was found to be the optimum condition. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123770DOI Listing

Recognition of core microbial communities contributing to complex organic components degradation during dry anaerobic digestion of chicken manure.

Bioresour Technol 2020 Jul 2;314:123765. Epub 2020 Jul 2.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Innovation Base of Groundwater & Environmental System Engineering, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Microbial metabolism of complex organic components can drive different microbial communities, which is significant to the process of dry anaerobic digestion (AD). However, possible mechanisms between organic components and the corresponding microbial communities during the process of dry AD is poorly investigated. Results showed that the microbial species affecting the degradation of organic components were 69 nodes (13. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123765DOI Listing

Enhancement of pollutants removal from saline wastewater through simultaneous anammox and denitrification (SAD) process with glycine betaine addition.

Bioresour Technol 2020 Jul 6;315:123784. Epub 2020 Jul 6.

Department of Civil and Environmental Engineering, Water Technology Center, Hong Kong Branch of Chinese National Engineering Research Center for Control & Treatment of Heavy Metal Pollution, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Enhanced pollutants removal from saline wastewater was investigated in simultaneous anammox and denitrification (SAD) process with glycine betaine (GB) addition. Long-term operation indicated the optimal GB dose was around 0.4 mM, which enhanced both anammox and denitrifying activity by 30% and 45%, respectively. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123784DOI Listing

Digestive solubilization of Cd in highly-contaminated sediment by marine deposit feeders: The roles of intestinal surfactants in Cd mobilization and Re-Adsorption processes.

Environ Pollut 2020 Jul 2;266(Pt 3):115149. Epub 2020 Jul 2.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, China.

Marine deposit feeders are of ecological significance in transferring sedimentary Cd along aquatic food chains. A key process for this transfer is these organisms' dietary uptake of Cd via solubilization of Cd present in ingested contaminated sediment. To better understand the bioavailability of sedimentary Cd to deposit feeders, the present study used in vitro extraction experiments to explore the contribution of different digestive agents (proteins, amino acids and surfactants) to the solubilization of Cd from sediment collected in a highly-contaminated Chinese bay. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115149DOI Listing

Highly efficient removal of thallium in wastewater by MnFeO-biochar composite.

J Hazard Mater 2020 Jun 25;401:123311. Epub 2020 Jun 25.

Key Laboratory of Water Quality and Conservation in the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, Guangzhou 510006, China. Electronic address:

Thallium (Tl), is a highly toxic trace metal in the natural environment. Emerging Tl pollution in waters has gradually become a global concern. However, limited removal technologies are available for Tl-containing wastewater. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123311DOI Listing

Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.

Eur J Med Chem 2020 Jun 30;202:112475. Epub 2020 Jun 30.

Department of Pharmacy, Affiated Tumor Hospital of Guangxi Medical University, Nanning, PR China. Electronic address:

A series of rasagiline-clorgyline hybrids was designed, synthesized and investigated in vitro for their inhibition of monoamine oxidase and amyloid-β aggregation. Most of compounds were found to be selective and highly potent hMAO-B inhibitors showing IC values in the nanomolar, and exhibited a moderate inhibition of amyloid-β aggregation. 7-((5-(methyl(prop-2-yn-1-yl)amino) pentyl)oxy)chroman-4-one (6j) was the most interesting compound identified in this research, endowed with higher hMAO-B potency (IC = 4 nM) and selectivity (SI > 25000) compared to the reference selective inhibitor rasagiline (IC = 141 nM, SI > 355), and exhibited good inhibitory activity against Aβ aggregation (40. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112475DOI Listing

A case of one lung adenocarcinoma patient harboring a novel FAM179A-ALK (F1, A19) rearrangement responding to lorlatinib treatment.

Lung Cancer 2020 Jun 24;147:26-29. Epub 2020 Jun 24.

Department of Oncology, The 904 Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Wuxi, Jiangsu, 214044, PR China. Electronic address:

The FAM179A gene has recently been screened as a new fusion partner fusing to the anaplastic lymphoma kinase gene (ALK) in plasma cell-free DNA (cfDNA) of patients with non-small-cell lung cancer (NSCLC). However, the response of patients with NSCLC harboring the FAM179A-ALK fusion to ALK inhibitors remains unknown. In this study we report a novel FAM179A-ALK rearrangement variant (F1, A19) identified by next-generation sequencing in an NSCLC patient with multiple brain metastases (M1c). Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.026DOI Listing

Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway.

J Neuroimmunol 2020 Jun 23;346:577284. Epub 2020 Jun 23.

Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China; Research Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, China; Dept. of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China. Electronic address:

Emerging evidence suggests an association of Alzheimer's Disease (AD) with microglial and astrocytic dysregulation. Recent studies have proposed that activated microglia can transform astrocytes to a neurotoxic A1 phenotype, which has been shown to be involved in the promotion of neuronal damage in several neurodegenerative diseases, including AD. In the present study, we observed an obvious microglial activation and A1-specific astrocyte response in the brain tissue of APP/PS1 Tg mice. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577284DOI Listing

Rabies viruses of different virulence regulates inflammatory responses both in vivo and in vitro via MAPK and NF-κB pathway.

Mol Immunol 2020 Jul 8;125:70-82. Epub 2020 Jul 8.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, NHC Key Laboratory of Biosafety, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address:

Immune responses and central nervous system dysfunction are two main factors to be considered during rabies virus (RABV) infection. However, the mechanisms by which RABV strains of different virulence regulate with chemokine expression and the signaling pathways responsible for the immune responses in the terminal stage of infection both in vivo and in vitro have not been fully elucidated. In this study, we found low expression levels of proinflammatory chemokines in the mouse brain upon infection with street RABV strains (CXZ17 and HN10) at the late stage of infection. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.011DOI Listing

A novel U-Net approach to segment the cardiac chamber in magnetic resonance images with ghost artifacts.

Comput Methods Programs Biomed 2020 Jun 24;196:105623. Epub 2020 Jun 24.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address:

Objective: We propose a robust technique for segmenting magnetic resonance images of post-atrial septal occlusion intervention in the cardiac chamber.

Methods: A variant of the U-Net architecture is used to perform atrial segmentation via a deep convolutional neural network, and we compare performance with the Kass snake model. It can be used to determine the surgical success of atrial septal occlusion (ASO) pre- and post- the implantation of the septal occluder, which is based on the volume restoration of the right atria (RA) and left atria (LA). Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105623DOI Listing

Complexation of Fe(III)/Catechols in atmospheric aqueous phase and the consequent cytotoxicity assessment in human bronchial epithelial cells (BEAS-2B).

Ecotoxicol Environ Saf 2020 Jul 8;202:110898. Epub 2020 Jul 8.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Recent research has shown that the complexation of metals-organics plays an important role in atmospheric particulate matter, whose health effects should be taken into account. This work investigates the interactions between catechols (CAs), i.e. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110898DOI Listing
July 2020
2.762 Impact Factor

Prevalence of Haemophilus parasuis"Glaesserella parasuis" in pigs in China: A systematic review and meta-analysis.

Prev Vet Med 2020 Jul 1;182:105083. Epub 2020 Jul 1.

College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, PR China. Electronic address:

Haemophilus parasuis, a gram-negative bacterium as an early commensal colonizer in the upper respiratory tract of weaning pigs (Sus scrofa), is one of the most important bacterial pathogens affecting pig populations. It is the causative agent of Glässer's disease, causing systemic infection and polyserositis, meningitis, and arthritis. H. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.105083DOI Listing

Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis.

EBioMedicine 2020 Jul 8;57:102878. Epub 2020 Jul 8.

School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China. Electronic address:

Background: Myopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect the biological processes affecting myopia progression.

Methods: Human Genetic Analyses: (1) gene set analysis (GSA) of new genome wide association study (GWAS) data for 593 individuals with high myopia (refraction ≤ -6 diopters [D]); (2) over-representation analysis (ORA) of 196 genes with de novo mutations, identified by whole genome sequencing of 45 high-myopia trio families, and (3) ORA of 284 previously reported myopia risk genes. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102878DOI Listing

Theoretical study on resonance Raman spectra of meso-tetrakis(3,5-di-tertiarybutylphenyl)-porphyrin due to the second-order Herzberg-Teller mechanism.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118659. Epub 2020 Jul 2.

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun, Beijing 100190, People's Republic of China.

Using quantum chemistry computations TDDFT//B3LYP/6-31G(d), we study resonance Raman spectra of the Q band for meso-tetrakis(3,5-di-tertiarybutylphenyl)-porphyrin (HTBPP) molecule due to the Franck-Condon and non-Condon mechanisms including the Herzberg-Teller and second-order Herzberg-Teller terms. Generally, the Herzberg-Teller terms are large. However, for some vibrational modes, the second-order Herzberg-Teller terms are the strongest and dominate resonance Raman spectra, which may also impact on fluorescence and absorption spectra. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118659DOI Listing

Occurrence of two NDM-1-producing Raoultella ornithinolytica and Enterobacter cloacae in a single patient in China: probable a novel antimicrobial resistance plasmid transfer in vivo by conjugation.

J Glob Antimicrob Resist 2020 Jul 8. Epub 2020 Jul 8.

Affiliated dongfeng Hospital, Hubei University of Medicine, Hubei, Shiyan 442000, China. Electronic address:

Objectives: To identify the general features of acquisition of drug-resistance genes in two multi-drug resistantEnterobacteriaceae strains isolated from a single patient in China.

Methods: The whole-plasmid was sequenced by Illumina Hiseq 4000 and Pacbio RSII procedures. The plasmid conjugation transfer experiment were performed by the mating-out assay. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.06.022DOI Listing

Endogenous Cell Recruitment Strategy for Articular Cartilage Regeneration.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

School of Medicine, Nankai University, Tianjin 300071, PR China; Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA; No. 28 Fuxing Road, Haidian District, Beijing 100853, PR China. Electronic address:

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and tissue engineering techniques are emerging as promising approaches for AC regeneration and repair. Although the use of cell-seeded scaffolds prior to implantation can regenerate and repair cartilage lesions to some extent, these approaches are still restricted by limited cell sources, excessive costs, risks of disease transmission and complex manufacturing practices. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.008DOI Listing

The Involvement of Notch1 Signaling Pathway in Mid-aged Female Rats under Chronic Restraint Stress.

Neurosci Lett 2020 Jul 8:135244. Epub 2020 Jul 8.

Research Center of Neurobiology, Fujian Medical University, Fuzhou 350122, Fujian Province, China. Electronic address:

Women are vulnerable to adverse stress events, especially during perimenopause. Substantial evidence has associated the impaired neuronal plasticity with abnormal behaviors under stressful conditions in animals. The Notch signaling pathway is critical for neuronal plasticity in the structure and function of brain areas. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135244DOI Listing

Influence of Distance and Near Visual Impairment on Self-reported Near Visual Functioning in a Multi-country Study.

Ophthalmology 2020 Jul 8. Epub 2020 Jul 8.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: To assess the influence of distance and near visual impairment on self-reported near visual functioning (VF) among adults in a multi-country study.

Design: Population-based cross-sectional study.

Participants: Participants aged ≥35 years were randomly selected with cluster sampling at seven sites: rural sites in Nepal (Kaski) and India (Madurai), a semi-rural site in China (Shunyi), semi-urban sites in South Africa (Durban) and Niger (Dosso), and urban sites in the United States (Los Angeles) and China (Guangzhou). Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.07.006DOI Listing

Cardiotoxicity of doxorubicin-based therapy: What is the protective cognition that phytochemicals provide us?

Pharmacol Res 2020 Jul 8:105062. Epub 2020 Jul 8.

Chinese Medicine Innovation Institute, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China. Electronic address:

Doxorubicin (DOX) continues to attract the interest of preclinical and clinical investigations despite its longer-than-50-year record of longevity. The clinical application of DOX can be regarded as a sort of double-edged sword. On one hand, anthracyclines play an indisputable key role in the treatment of tumors; on the other hand, their chronic administration leads to cardiomyopathy and congestive heart failure, which is usually refractory to common medications. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.105062DOI Listing

Enriched environment rearing from birth reduced anxiety, improved learning and memory, and promoted social interactions in adult male mice.

Neuroscience 2020 Jul 8. Epub 2020 Jul 8.

Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Sciences, Peking-Tsinghua Center for Life Sciences, and Peking University McGovern Institute, Peking University, Beijing 100871, China. Electronic address:

Rearing rodents in an enriched environment (EE), with increased sensory stimulations and social interactions, is a well-established model for naturally increasing neural activity. It is well-known that EE-rearing of rodents from adolescence or during adulthood leads to extensive biochemical, morphological, electrophysiological and behavioral changes. Here, we examine the effects of EE-rearing from birth on adult behavior. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.07.004DOI Listing

The Ambient Ozone and COVID-19 Transmissibility in China: A Data-Driven Ecological Study of 154 Cities.

J Infect 2020 Jul 8. Epub 2020 Jul 8.

Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2020.07.011DOI Listing

IFNβ-induced exosomal linc-EPHA6-1 promotes cytotoxicity of NK cells by acting as a ceRNA for hsa-miR-4485-5p to up-regulate NKp46 expression.

Life Sci 2020 Jul 8:118064. Epub 2020 Jul 8.

Provincial Key Laboratory for Transfusion-Transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan 610052, China; Toronto General Research Institute, University of Toronto, ON M5G 1L6, Canada. Electronic address:

Aims: Exosomes contain functional molecules from their cells of origin and can enter recipient cells for intercellular communication. Interferon β (IFNβ) has been shown to induce some lncRNAs to regulate host immune response and play a major role in the positive regulation of the activity of natural killer (NK) cells. We aim to clarify whether IFNβ induced exosomes can regulate the cytotoxicity of NK cells by transferring specific lncRNAs into NK cells. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118064DOI Listing

Evolutionary biogeography of the reef-building coral genus Galaxea across the Indo-Pacific ocean.

Mol Phylogenet Evol 2020 Jul 8:106905. Epub 2020 Jul 8.

Marine Biophysics Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.

Stony corals (Scleractinia) form the basis for some of the most diverse ecosytems on Earth, but we have much to learn about their evolutionary history and systematic relationships. In order to improve our understanding of species in corals we here investigated phylogenetic relationships between morphologically defined species and genetic lineages in the genus Galaxea (Euphyllidae) using a combined phylogenomic and phylogeographic approach. Previous studies revealed the nominal species G. Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106905DOI Listing

Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia.

Exp Neurol 2020 Jul 8:113399. Epub 2020 Jul 8.

Department of neurology, General Hospital of Northern Theater Command, China. Electronic address:

After cerebral ischemia/reperfusion injury, pro-inflammatory M1-like and anti-inflammatory M2-like phenotypes of microglia are involved in neuroinflammation, in which NLRP3 inflammasome plays an essential role. Kv1.3 channel has been recognized as neuro-immunomodulatory target, but it is not clear as to its role in the neuroinflammation after cerebral ischemic injury. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113399DOI Listing

Real-world big-data studies in laboratory medicine: current status, application, and future considerations.

Clin Biochem 2020 Jul 8. Epub 2020 Jul 8.

Department of Clinical Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, PR China. Electronic address:

With the recent developments in information technology, real world big data studies (RWBDSs) have attracted increasing attention in the field of medicine. In RWBDSs, clinical laboratory data is an important part of the wider scope of real-world medical data, and its standardized use is critical for the generation of high-quality real-world evidence. To improve the core functioning and competitiveness of clinical laboratories as well as provide high-quality medical services for patients, it is important to construct an information analysis model and perform RWBDSs. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2020.06.014DOI Listing

Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force.

Dev Cell 2020 Jul 8. Epub 2020 Jul 8.

Department of Comprehensive Dentistry, College of Dentistry, Texas A&M University, Dallas, TX 75246, USA. Electronic address:

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as multi-potential stem cells (PDLSCs) giving rise to PDL, alveolar bone, and cementum. They support periodontium tissue turnover and injury repair. Read More

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http://dx.doi.org/10.1016/j.devcel.2020.06.006DOI Listing

Diagnostic accuracy of interleukin-27 in tuberculous pleurisy: A systematic review and Meta-analysis.

QJM 2020 Jul 11. Epub 2020 Jul 11.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Medical University.

Objective: This study aimed to conduct a systematic review of the diagnostic value of interleukin-27 (IL-27) for tuberculous pleurisy.

Methods: Literature on IL-27 diagnosis of tuberculous pleurisy was retrieved and screened from 6 databases (4 English databases and 2 Chinese databases). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and summary receiver operating characteristic curve (SROC) were measured to assess accurately the comprehensive evaluation of IL-27 for tuberculous pleurisy. Read More

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http://dx.doi.org/10.1093/qjmed/hcaa215DOI Listing

New insights into Arabidopsis transcriptome complexity revealed by direct sequencing of native RNAs.

Nucleic Acids Res 2020 Jul 11. Epub 2020 Jul 11.

School of Life Sciences and Center for Soybean Research of the State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.

Arabidopsis thaliana transcriptomes have been extensively studied and characterized under different conditions. However, most of the current 'RNA-sequencing' technologies produce a relatively short read length and demand a reverse-transcription step, preventing effective characterization of transcriptome complexity. Here, we performed Direct RNA Sequencing (DRS) using the latest Oxford Nanopore Technology (ONT) with exceptional read length. Read More

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http://dx.doi.org/10.1093/nar/gkaa588DOI Listing
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