741,038 results match your criteria Chinese medical sciences journal = Chung-kuo i hsueeh k'o hsueeh tsa chih / Chinese Academy of Medical Sciences[Journal]


Thyroid Cancer Benefits the Prognosis of Ovarian Cancer: A SEER-Based Study.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China.

Introduction: To explore the effect of a second thyroid cancer (TC) on ovarian cancer (OC) patient survival, we compared OC patients with or without a second primary TC using data from the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: Data for OC only, female TC only and OC patients with a second TC (OC2TC) from two periods, 2000-2014 and 1980-1994, were extracted from the SEER database. Differences in clinicopathological and treatment characteristics were analysed using the chi-square test. Read More

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http://link.springer.com/10.1007/s12325-019-00918-5
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http://dx.doi.org/10.1007/s12325-019-00918-5DOI Listing
March 2019
5 Reads

Divergent responses of bacterial activity, structure, and co-occurrence patterns to long-term unbalanced fertilization without nitrogen, phosphorus, or potassium in a cultivated vertisol.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.

Unbalanced fertilization lacking nitrogen (N), phosphorus (P), or potassium (K) is a worldwide phenomenon; however, whether they affect bacterial community composition and intraspecific interactions in a similar pattern and how they affect bacterial activity are not systematically compared. Soils under different kinds of unbalanced fertilization in a 21-year field experiment were collected to investigate the variation in dehydrogenase activity (DHA), bacterial community diversity, structure, composition, and possible interactions. Compared to the balanced fertilization of NPK, the DHA from unbalanced fertilization of NP, PK, and NK was 8. Read More

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http://dx.doi.org/10.1007/s11356-019-04839-2DOI Listing

Polychlorinated naphthalene emissions to the atmosphere from typical secondary aluminum smelting plants in southwestern China: concentrations, characterization, and risk evaluation.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

Secondary aluminum smelting industry, as an important source of polychlorinated naphthalene (PCN) in environment, has been concerned in recent years. To figure out the emission characteristics of PCNs and the potential influence on surrounding environment, two typical secondary aluminum smelting plants were selected and PCNs were determined in flue gas, fly ash, aluminum slag, soil, and air samples collected at and around the plants by GC-MS coupled with DFS. PCN emission factors from the flue gas of the two plants (mean 0. Read More

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http://dx.doi.org/10.1007/s11356-019-04744-8DOI Listing

Religion Affiliation and Depression Risk: Factory Workers Working in Hi-Tech Companies in Shanghai, China.

J Relig Health 2019 Mar 16. Epub 2019 Mar 16.

School of Social Work and Public Administration, East China University of Science & Technology, 130 Meilong Road, Shanghai, 200237, China.

This study examines factors contributing to depression among migrant factory workers in Shanghai. A survey was designed with mental health questions under a framework explaining: (1) social capital, (2) migratory stress, and (3) mental health consequences. With a return rate of 98. Read More

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http://dx.doi.org/10.1007/s10943-019-00790-1DOI Listing

Elemental analysis and imaging of sunscreen fingermarks by X-ray fluorescence.

Anal Bioanal Chem 2019 Mar 16. Epub 2019 Mar 16.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.

Chemical composition in fingermarks could provide useful information for forensic studies and applications. Here, we evaluate the feasibility of analysis and imaging of fingermarks via elements by synchrotron radiation X-ray fluorescence (SRXRF) and commercial X-ray fluorescence (XRF). As a proof of concept, we chose four brands of sunscreens to make fingermarks on different substrates, including plastic film, glass, paper, and silicon wafer. Read More

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http://dx.doi.org/10.1007/s00216-019-01718-0DOI Listing

Characterization of a blaIMP-4-carrying plasmid from Enterobacter cloacae of swine origin.

J Antimicrob Chemother 2019 Mar 16. Epub 2019 Mar 16.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.

Objectives: To characterize an MDR blaIMP-4-harbouring plasmid from Enterobacter cloacae EC62 of swine origin in China.

Methods: Plasmid pIMP-4-EC62 from E. cloacae EC62 was transferred by conjugation via filter mating into Escherichia coli J53. Read More

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http://dx.doi.org/10.1093/jac/dkz107DOI Listing

Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells.

Med Sci Monit 2019 Mar 17;25:2002-2008. Epub 2019 Mar 17.

Department of Respiratory Medicine, Qingdao Municipal Hospital, Qingdao, Shandong, China (mainland).

BACKGROUND Murrayanine is a carbazole alkaloid derived from Murraya koenigii, which has been used in traditional Chinese medicine in the treatment of cancer. This study aimed to investigate the effects of murrayanine on human lung adenocarcinoma cells in vitro and to investigate the mechanisms of its action. MATERIAL AND METHODS A549 human lung adenocarcinoma cells and MRC-5 human lung fibroblasts were grown in culture, and an MTT assay determined cell viability. Read More

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http://dx.doi.org/10.12659/MSM.913873DOI Listing

Surgical resection of carotid-jugular arteriovenous fistula after multiple failed embolisation.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.

Carotid-jugular fistula is a rare presentation of arteriovenous fistula. A case of a 60-year-old Chinese man who presented with iatrogenic carotid-jugular fistula with multiple fistulous points was reported. His presenting complaint was a gradually enlarging right pulsatile neck mass complicated by worsening symptoms of congestive cardiac failure. Read More

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http://dx.doi.org/10.1136/bcr-2018-228232DOI Listing

Selenium translocation in the soil-rice system in the Enshi seleniferous area, Central China.

Sci Total Environ 2019 Mar 1;669:83-90. Epub 2019 Mar 1.

State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China. Electronic address:

Rice is an important source of selenium (Se) exposure; however, the transformation and translocation of Se in the soil-rice system remain poorly understood. Here, we investigated the speciation of Se in Se-rich soils from Enshi, Central China and assessed which Se species is bioavailable for rice grown in Enshi. Extremely high Se concentrations (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193096
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http://dx.doi.org/10.1016/j.scitotenv.2019.02.451DOI Listing
March 2019
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Climate and soil parameters are more important than denitrifier abundances in controlling potential denitrification rates in Chinese grassland soils.

Sci Total Environ 2019 Mar 8;669:62-69. Epub 2019 Mar 8.

Key Laboratory of Environmental and Applied Microbiology, CAS, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address:

Denitrification is an important process that influences nitrogen (N) loss and the production of greenhouse gas in grassland soils. However, the relative contributions of abiotic and biotic factors to soil denitrification potential at the regional and sub-regional scales in grassland ecosystems remain elusive. In this study, soil samples were collected from 21 sites at three steppes of China, including the Inner Mongolia Plateau (IMP), the Xinjiang Autonomous Region (XAR) and the Tibetan Plateau (TP) grasslands. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.093DOI Listing

Robust capped L1-norm twin support vector machine.

Neural Netw 2019 Feb 18;114:47-59. Epub 2019 Feb 18.

Institute of Forest Resource Information Techniques, Chinese Academy of Forestry, Beijing 100091, PR China. Electronic address:

Twin support vector machine (TWSVM) is a classical and effective classifier for binary classification. However, its robustness cannot be guaranteed due to the utilization of squared L2-norm distance that can usually exaggerate the influence of outliers. In this paper, we propose a new robust capped L1-norm twin support vector machine (CTWSVM), which sustains the advantages of TWSVM and promotes the robustness in solving a binary classification problem with outliers. Read More

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http://dx.doi.org/10.1016/j.neunet.2019.01.016DOI Listing
February 2019

Electrospun spongy zero-valent iron as excellent electro-Fenton catalyst for enhanced sulfathiazole removal by a combination of adsorption and electro-catalytic oxidation.

J Hazard Mater 2019 Mar 11;371:576-585. Epub 2019 Mar 11.

CAS Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China; CAS Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, Fujian 361021, China. Electronic address:

In this study, a highly active electro-Fenton catalyst, spongy zero-valent iron (ZVI), has been developed at first via in-situ synthesis of ZVI nanoparticles (NPs) on an electrospun three-dimensional (3D) nanofiber network. The spongy ZVI effectively overcame the defects of easy aggregation of ZVI NPs and ferric sludge accumulation during the electro-catalytic process. Then, a three-dimensional electro-Fenton (3D-EF) system using the as-fabricated spongy ZVI as particle catalytic electrodes was designed, which presented a significant synergistic effect of adsorption and electro-catalytic oxidation on the enhanced removal of a widely used antibiotic, sulfathiazole (STZ) from water. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.03.043DOI Listing
March 2019
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Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study.

J Pharm Biomed Anal 2019 Mar 5;169:254-259. Epub 2019 Mar 5.

Tasly Academy, Tasly Holding Group Co., Ltd., Tianjin 300410, China; State Key Laboratory of Core Technology in Innovation Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China; Tasly Pharmaceuticals Inc, Rockville, MD 20850, USA.

As one of the main constituents of Compound Danshen Dripping Pills (CDDP), Panax notoginseng (PN) plays a pivotal role in the treatment of cardiovascular diseases. Numerous researches have proved that the dammarane type saponins including notoginsenoside R1 (NR1), ginsenoside Rg1 (GRg1) and ginsenoside Rb1 (GRb1) are the main bioactive components of PN in CDDP. An efficient, realiable and sensitive liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis method for simultaneously detecting NR1, GRg1 and GRb1 in human plasma was established and applied to the pharmacokinetics study of the three PN saponins after oral administration of CDDP. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.008DOI Listing

The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways.

Phytomedicine 2019 Feb 18;58:152864. Epub 2019 Feb 18.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, 30 Qingquan Road of Laishan District, Yantai 264003, Shandong, PR China. Electronic address:

Background: Ulcerative colitis (UC) is a chronic inflammatory condition of the intestines and is difficult to cure once diagnosed. The efficacy of the current clinical treatment for UC is limited. Common anti-inflammatory drugs are prone to adverse effects, while novel biological agents are expensive, although tolerated by patients. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152864DOI Listing
February 2019

Community greenness, blood pressure, and hypertension in urban dwellers: The 33 Communities Chinese Health Study.

Environ Int 2019 Mar 14;126:727-734. Epub 2019 Mar 14.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Living in greener areas has many health benefits, but evidence concerning the effects on blood pressure remains mixed. We sought to assess associations between community greenness and both blood pressure and hypertension in Chinese urban dwellers, and whether the associations were mediated by air pollution, body mass index, and physical activity.

Methods: We analyzed data from 24,845 adults participating in the 33 Communities Chinese Health Study, which was conducted in Northeastern China during 2009. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.068DOI Listing

Distribution and speciation of copper in rice (Oryza sativa L.) from mining-impacted paddy soil: Implications for copper uptake mechanisms.

Environ Int 2019 Mar 14;126:717-726. Epub 2019 Mar 14.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address:

Long term mining activities can cause significant metal pollution in the environment, thereby showing potential risk to the paddy field. Elucidating the interfacial processes of trace metals from contaminated paddy soil to rice within the rhizosphere can provide important information on metal biogeochemistry and food safety. The current study aims to explore the spatial distribution and molecular speciation of Cu from rhizosphere to rice plant in a mining-impacted paddy soil, and reveal the possible uptake mechanisms. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.045DOI Listing

Rapid thermal-acid hydrolysis of spiramycin by silicotungstic acid under microwave irradiation.

Environ Pollut 2019 Feb 25;249:36-44. Epub 2019 Feb 25.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

Spiramycin is a widely used macrolide antibiotic and exists at high concentration in production wastewater. A thermal-acid hydrolytic pretreatment using silicotungstic acid (STA) under microwave (MW) irradiation was suggested to mitigate spiramycin from production wastewater. Positive correlations were observed between STA dosage, MW power, interaction time and the hydrolytic removal efficiencies, and an integrative equation was generalized quantitively. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.074DOI Listing
February 2019

Profiling the Clostridia with butyrate-producing potential in the mud of Chinese liquor fermentation cellar.

Int J Food Microbiol 2019 Mar 1;297:41-50. Epub 2019 Mar 1.

National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, PR China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR China; National Engineering Research Center of Solid-State Brewing, Luzhou 646000, PR China. Electronic address:

Butyrate and its derivates pertain to the key aroma contributors of strong-flavour baijiu, a kind of Chinese liquors, that is produced from grains by solid-state multispecies anaerobic fermentation in a mud cellar. Microbes inhabiting in the fermentation pit mud largely determines baijiu's flavour and quality. In order to shed light on the microbial functional groups driving butyrate production in pit mud, clone library analysis was firstly performed and the results demonstrated that Clostridia (relative abundance: 50%) and Bacilli (37%) were major groups possessing butyrate kinase (buk) pathway and Clostridia (98%) dominated butyryl-CoA:acetate CoA-transferase (but) pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681605193005
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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.02.023DOI Listing
March 2019
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Physiological, transcriptional, and metabolic alterations in spaceflight-subjected Senna obtusifolia.

Plant Physiol Biochem 2019 Mar 9;139:33-43. Epub 2019 Mar 9.

Tianjin Tasly Modern TCM Resources Co. Ltd, Tianjin, 300400, China.

Senna obtusifolia is a widely used medicinal herb in Asian countries. To select elite cultivars, S. obtusifolia seeds were carried by "ShenZhou Ⅷ" recoverable satellite to space. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.03.009DOI Listing

Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies.

Eur J Med Chem 2019 Mar 9;170:112-125. Epub 2019 Mar 9.

ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address:

A series of 24 benzothiadiazine derivatives with structural novelty were designed, synthesized and biologically evaluated as PI3Kδ-selective inhibitors. As a consequence of the structure-activity relationship (SAR) study, compounds 63 and 71 were identified with single-digit nanomolar IC values against PI3Kδ and submicromolar GI values against human malignant B-cell line SU-DHL-6. Furthermore, chiral resolution of the key amine intermediate of these two compounds was performed to achieve corresponding enantiomers. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.005DOI Listing

Optimal construction and pharmacokinetic study of CZ48-loaded poly (lactic acid) microbubbles for controlled drug delivery.

Colloids Surf B Biointerfaces 2019 Feb 23;178:269-275. Epub 2019 Feb 23.

College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China. Electronic address:

CZ48, a prodrug of camptothecin (CPT) with derivative resistant to lactone hydrolysis, suffers from limited application for cancer treatment due to poor water-solubility, thus causing its low bioavailability and absorption in vivo. To echo this problem, CZ48 was incorporated into poly (lactic acid) (PLA) microbubbles via a double emulsion technique (W/O/W), and the successful loading was confirmed by X-ray diffraction (XRD) patterns and confocal laser scanning microscope (CLSM). The obtained CZ48-loaded microbubbles had a diameter ranging from 0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.047DOI Listing
February 2019

Adjunctive ondansetron for schizophrenia: A systematic review and meta-analysis of randomized controlled trials.

J Psychiatr Res 2019 Mar 5;113:27-33. Epub 2019 Mar 5.

Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address:

The serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor has been implicated in the pathogenesis of schizophrenia. This meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of adjunctive ondansetron, a potent 5-HT3 receptor antagonist, in the treatment of schizophrenia. Only RCTs examining adjunctive ondansetron for schizophrenia were included. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.024DOI Listing

Robotic versus open resection of benign nonadrenal retroperitoneal tumors: a propensity score-matched study.

Int J Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Hepatobiliary and Pancreatic Surgical Oncology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China. Electronic address:

Background: Robotic resection of benign nonadrenal retroperitoneal tumors (BNRTs) is considered safety and feasibility. However, whether robotic BNRT resection (RBR) is superior to open BNRT resection (OBR) has not been reported. The comparative study was designed to analyze the short outcomes of RBR versus OBR on patients with BNRTs. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.021DOI Listing

Profiles, variability and predictors of concentrations of blood trihalomethanes and urinary haloacetic acids along pregnancy among 1760 Chinese women.

Environ Res 2019 Mar 8;172:665-674. Epub 2019 Mar 8.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Blood trihalomethanes (THMs) and urinary haloacetic acids (HAAs) are the leading candidate biomarkers for disinfection byproduct (DBP) exposure. However, no studies have assessed the exposure profiles, temporal variability, and potential predictors of these biomarkers during pregnancy. Here we collected blood (n = 4304) and urine samples (n = 4165) from 1760 Chinese pregnant women during early, mid-, and late pregnancy, which were separately analyzed for 4 THMs and 2 HAAs. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.017DOI Listing

"Off-on" signal amplification strategy amperometric immunosensor for ultrasensitive detection of tumour marker.

Biosens Bioelectron 2019 Mar 9;132:265-270. Epub 2019 Mar 9.

Department of Chemistry, Capital Normal University, Beijing 100048, China. Electronic address:

Reducing background signal is an effective method to improve the sensitivity of amperometric immunosensors, which are significant in the detection of cancer. Herein, a novel immunosensor probe was synthesised using zeolitic imidazolate framework-hydroquinone-bovine serum albumin (ZIF-8-HQ-BSA). Based on the probe, an "off-on" strategy was applied in the immunosensor to amplify ΔI, the current signal "turn off and on". Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.013DOI Listing

Validation of methylation-based forensic age estimation in time-series bloodstains on FTA cards and gauze at room temperature conditions.

Forensic Sci Int Genet 2019 Mar 6;40:168-174. Epub 2019 Mar 6.

National Engineering Laboratory for Forensic Science, Key Laboratory of Forensic Genetics of Ministry of Public Security, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Ministry of Public Security, Beijing, China. Electronic address:

We previously proposed a prediction model consisting of 9 CpG sites for forensic age estimation with high practical potentials in Chinese males. Here, we further evaluated the performance of this prediction model in two independent batches of time-series bloodstain samples naturally exposed to room temperature conditions. The first batch consists of 30 Han Chinese males (18-59 years of age) whose peripheral blood was converted into bloodstains on Flinders Technology Association (FTA) cards and naturally exposed to room temperature conditions for different time points up to 3 months. Read More

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http://dx.doi.org/10.1016/j.fsigen.2019.03.006DOI Listing

Cis-khellactone inhibited the proinflammatory macrophages via promoting autophagy to ameliorate imiquimod-induced psoriasis.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:

Psoriasis is a chronic inflammatory skin disease with unresolved pathogenesis. Studies on the pathogenesis of psoriasis have been extensively carried out, but treatments are still not satisfactory. In this study, we found improvement after treatment with cis-khellactone, a small molecular natural product, in imiquimod (IMQ)-challenged C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.021DOI Listing

A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol.

Int J Antimicrob Agents 2019 Mar 13. Epub 2019 Mar 13.

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.. Electronic address:

Intrinsic resistance of bacteria to antibiotics plays an increasingly significant role in antibiotic resistance. However, the breadth of intrinsic resistance has not been fully elucidated. Here we identified a novel class of chloramphenicol acetyltransferase (type C CAT or CATC) in Vibrio parahaemolyticus and its closely related species V. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.03.012DOI Listing
March 2019
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Baseline serum C-reactive protein levels may predict antidepressant treatment responses in patients with major depressive disorder.

J Affect Disord 2019 Mar 4;250:432-438. Epub 2019 Mar 4.

Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China, 210009. Electronic address:

Background: Inflammation has been shown previously to predict antidepressant treatment response. This retrospective study was conducted to test if the baseline serum C-reactive protein (CRP) levels could predict antidepressant treatment responses in a Chinese sample.

Methods: 75 adult inpatients (26 male, 49 female) with major depressive disorder (MDD) diagnosed according to DSM-5 were included in this study. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.001DOI Listing

The association between Toxoplasma gondii infection and postpartum blues.

J Affect Disord 2019 Mar 5;250:404-409. Epub 2019 Mar 5.

Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, and Key Laboratory of Tropical Disease Control of the Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510275, China; Biomedical Research Centre and Ecosystems and Environment Research Centre, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK. Electronic address:

Introduction And Aim: Toxoplasma gondii is an intracellular protozoan parasite infecting approximately 30% of the global human population. It has often been suggested that chronic infection with T. gondii is related to personality changes and various mental disorders including depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.013DOI Listing

Non-pharmacological and pharmacological interventions relieve insomnia symptoms by modulating a shared network: A controlled longitudinal study.

Neuroimage Clin 2019 Mar 4;22:101745. Epub 2019 Mar 4.

Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, MA, USA. Electronic address:

Background: Primary insomnia (PI) is one of the most common complaints among the general population. Both non-pharmacological and pharmacological therapies have proven effective in treating primary insomnia. However, the underlying mechanism of treatment remains unclear, and no studies have compared the underlying mechanisms of different treatments. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101745DOI Listing

Physiological significance of R-fMRI indices: Can functional metrics differentiate structural lesions (brain tumors)?

Neuroimage Clin 2019 Mar 1;22:101741. Epub 2019 Mar 1.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai Neurosurgical Clinical Center, Shanghai, China. Electronic address:

Resting-state functional MRI (R-fMRI) research has recently entered the era of "big data", however, few studies have provided a rigorous validation of the physiological underpinnings of R-fMRI indices. Although studies have reported that various neuropsychiatric disorders exhibit abnormalities in R-fMRI measures, these "biomarkers" have not been validated in differentiating structural lesions (brain tumors) as a concept proof. We enrolled 60 patients with intracranial tumors located in the unilateral cranialcavity and 60 matched normal controls to test whether R-fMRI indices can differentiate tumors, which represents a prerequisite for adapting such indices as biomarkers for neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101741DOI Listing

Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.

EBioMedicine 2019 Mar 14. Epub 2019 Mar 14.

Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address:

Background: Tyrosine kinase inhibitors (TKIs) are clinically effective in non-small cell lung cancer (NSCLC) patients harbouring epidermal growth factor receptor (EGFR) oncogene mutations. Genetic factors, other than EGFR sensitive mutations, that allow prognosis of TKI treatment remain undefined.

Methods: We retrospectively screened 423 consecutive patients with advanced NSCLC and EGFR 19del or 21L858R mutations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193016
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http://dx.doi.org/10.1016/j.ebiom.2019.03.023DOI Listing
March 2019
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Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release.

EBioMedicine 2019 Mar 14. Epub 2019 Mar 14.

Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, China; Marine Drug R&D Center, Institute of Oceangraphy, Minjiang University, Fuzhou 350108, China. Electronic address:

Background: Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical "don't find me" signal to the adaptive immune system. Equally CD47 is a critical "don't eat me" signal to the innate immune system and a regulator of the adaptive immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193015
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http://dx.doi.org/10.1016/j.ebiom.2019.03.018DOI Listing
March 2019
3 Reads

Self-Assembled Hexagonal Liquid Crystalline Gels as Novel Ocular Formulation with Enhanced Topical Delivery of Pilocarpine Nitrate.

Int J Pharm 2019 Mar 13. Epub 2019 Mar 13.

Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui Province 230012, People's Republic of China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, Anhui Province 230012, People's Republic of China. Electronic address:

The aim of this paper was to develop hexagonal liquid crystalline (H) gels that can be used as a novel ocular delivery system for pilocarpine nitrate (PN). H gels were prepared by a vortex method using phytantriol/triglyceride/water (71.15: 3. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.033DOI Listing

Andrographolide Derivative Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice.

Biochem Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China. Electronic address:

The therapeutic efficacy of immunosuppressive agents has been intensively studied for colitis management. We synthesized a series of andrographolide derivatives and reported their structure-activity-relationship and anti-inflammatory activity in our previous studies. Among these derivatives, compound 3b exhibited the most potent immunosuppressive activity. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.03.019DOI Listing

Paeoniflorin inhibits tributyltin chloride-induced apoptosis in hypothalamic neurons via inhibition of MKK4-JNK signaling pathway.

J Ethnopharmacol 2019 Mar 13. Epub 2019 Mar 13.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 20032, China. Electronic address:

Ethnopharmacological Relevance: Paeoniflorin (PF) exerts a significant protective effect against neurotoxicity and mitochondrial damage in neurons. However, the mechanisms underlying PF-mediated rescue remain elusive. Therefore, we endeavored to further research the molecular mechanisms underlying PF-mediated inhibition of tributyltin chloride (TBTC)-induced apoptosis of neurons. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.030DOI Listing

Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway.

J Ethnopharmacol 2019 Mar 13. Epub 2019 Mar 13.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China; Institute of Traditional Chinese Medicine Innovation, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China. Electronic address:

Ethnopharmacological Relevance: Rhodiola crenulata, a traditional Tibetan medicine, has shown promise in the treatment of hypobaric hypoxia (HH)-induced brain injury. However, the underlying mechanisms remain unclear. This study investigated the protective effects of R. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.028DOI Listing

Hypoglycemic effect of dietary fibers from bamboo shoot shell: An in vitro and in vivo study.

Food Chem Toxicol 2019 Mar 13. Epub 2019 Mar 13.

College of Food Science, Fujian Agriculture and Forestry University, China; Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China. Electronic address:

Bamboo shoot shell (BSS) was enzymatically decomposed to yield insoluble dietary fiber (IDF), soluble dietary fiber (SDF) and total dietary fiber (TDF), which were investigated for their hypoglycemic properties using in vitro and in vivo methods. The results indicated that SDF exhibited significantly higher glucose adsorbing capacity than those of IDF and TDF. Moreover, SDF showed similar inhibition potential against α-amylase with acarbose. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.008DOI Listing

Differentiation of glioblastoma from solitary brain metastases using radiomic machine-learning classifiers.

Cancer Lett 2019 Mar 13. Epub 2019 Mar 13.

Department of Neuro-oncology, Neurosurgery Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

This study aimed to identify the optimal radiomic machine-learning classifier for differentiating glioblastoma (GBM) from solitary brain metastases (MET) preoperatively. Four hundred and twelve patients with solitary brain tumors (242 GBM and 170 solitary brain MET) were divided into training (n =227) and test (n =185) cohorts. Radiomic features extraction was performed with PyRadiomics software. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.054DOI Listing

Visualizing mRNA in live mammalian cells.

Methods 2019 Mar 13. Epub 2019 Mar 13.

Department of Chemistry, Shanghai Normal University, Shanghai 200234, China; Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201800, China. Electronic address:

mRNAs play essential role in gene expression and regulation. Direct visualization of specific intracellular mRNAs can provide key information about mRNA distribution and dynamics that accelerating study of their functionality. This highlights the necessity of characterizing mRNA in mammalian cells with good spatial and temporal resolution. Read More

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http://dx.doi.org/10.1016/j.ymeth.2019.03.008DOI Listing

Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway.

Eur J Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Vascular smooth muscle cell (VSMC) proliferation plays a critical role in arterial remodeling during various vascular diseases including atherosclerosis and hypertension. Tanshinone I, a major component of Salvia miltiorrhiza, exerts protective effects against cardiovascular diseases. In this study, we investigated the effects of tanshinone I on VSMC proliferation, as well as the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.021DOI Listing

Enrichment of total flavones and licochalcone A from licorice residues and its hypoglycemic activity.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Traditional Chinese Medicine Chemical, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Industrial processing of glycyrrhizic leads to a lot of residues which are usually threw away randomly or used as feed. Therefore, the purpose of this study was to study licorice residues as a source of bioactive compounds with potentially applications. In this study, the enrichment and purification of total flavones from the licorice residues was achieved by using macroporous resins. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.026DOI Listing
January 2019

Aspirin inhibits hypoxia-mediated lung cancer cell stemness and exosome function.

Pathol Res Pract 2019 Mar 11. Epub 2019 Mar 11.

Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. Electronic address:

Background: Epidemiological studies have illustrated that regular aspirin consumption may decrease the risk of non-small cell lung cancer (NSCLC). The present study aims to investigate the mechanism of aspirin-induced inhibition of NSCLC development during hypoxia.

Methods: A549 cells were pre-treated with the vehicle control or aspirin and then subjected to hypoxic culture. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183172
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http://dx.doi.org/10.1016/j.prp.2019.03.008DOI Listing
March 2019
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Trichobisabolins A-H, eight new bisabolane derivatives from the marine-alga-epiphytic fungus Trichoderma asperellum Y6-2.

Fitoterapia 2019 Mar 13. Epub 2019 Mar 13.

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. Electronic address:

Eight new bisabolane derivatives, trichobisabolins A-H, along with two known ones, (3R,6R,7R)-1,10-bisaboladien-3-ol (9) and (3R,6R,7S)-1,10-bisaboladien-3,6-diol (10) were isolated from the culture of Trichoderma asperellum Y6-2, obtained from the surface of the marine red alga Chondrus ocellatus. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1-8 were assayed for inhibiting the growth of some marine-derived organisms, including four marine phytoplankton species, one marine zooplankton species, and five pathogenic bacteria. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.010DOI Listing

A novel homozygous FBXO43 mutation associated with male infertility and teratozoospermia in a consanguineous Chinese family.

Fertil Steril 2019 Mar 13. Epub 2019 Mar 13.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China. Electronic address:

Objective: To identify the genetic causes of male infertility characterized by teratozoospermia.

Design: Genetic studies.

Setting: Medical university. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.01.007DOI Listing

Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial.

Lancet 2019 Mar 13. Epub 2019 Mar 13.

Dana Center for Preventive Ophthalmology, Wilmer Eye Institute and Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Primary angle-closure glaucoma affects 20 million people worldwide. People classified as primary angle closure suspects have a higher but poorly quantified risk of developing glaucoma. We aimed to assess efficacy and safety of laser peripheral iridotomy prophylaxis against primary angle-closure glaucoma in Chinese people classified as primary angle closure suspects. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32607-2DOI Listing

Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection (Prolotherapy): A Randomized Controlled Trial With Long-term Partial Crossover.

Mayo Clin Proc 2019 Mar 13. Epub 2019 Mar 13.

Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Objective: To assess the efficacy and longer-term effectiveness of dextrose prolotherapy injections in participants with temporomandibular dysfunction.

Patients And Methods: A randomized controlled trial with masked allocation was conducted from January 14, 2013, through December 19, 2015. Forty-two participants (with 54 joints) meeting temporomandibular dysfunction criteria were randomized (1:1) to 3 monthly intra-articular injections (20% dextrose/0. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.07.023DOI Listing

Stroke in China: advances and challenges in epidemiology, prevention, and management.

Lancet Neurol 2019 Apr;18(4):394-405

Stroke Prevention Project Committee of National Health Commission of the People's Republic of China, Beijing, China.

With over 2 million new cases annually, stroke is associated with the highest disability-adjusted life-years lost of any disease in China. The burden is expected to increase further as a result of population ageing, an ongoing high prevalence of risk factors (eg, hypertension), and inadequate management. Despite improved access to overall health services, the availability of specialist stroke care is variable across the country, and especially uneven in rural areas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183050
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http://dx.doi.org/10.1016/S1474-4422(18)30500-3DOI Listing
April 2019
2 Reads

Pictographs of encephalitis in Chinese characters.

Authors:
Hongzhi Guan

Lancet Neurol 2019 Apr;18(4):331

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30077-8DOI Listing
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