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    Intravascular Foreign Bodies: A Single-Institution Experience and Description of a Novel Modified Percutaneous Retrieval Technique.
    Chin Med J (Engl) 2018 Feb;131(4):484-485
    Centro de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte, Estado de México 52786, México.

    Effects of Plasma Lipids and Statins on Cognitive Function.
    Chin Med J (Engl) 2018 Feb;131(4):471-476
    Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei 050051, China.
    Objective:: Dementia is the fourth most common cause of death in developed countries. The relationship between plasma lipids and cognitive function is complex and controversial. Due to the increasing life expectancy of the population, there is an urgent need to control vascular risk factors and to identify therapies to prevent and treat both cognitive impairment and dementia. Read More

    Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models.
    Chin Med J (Engl) 2018 Feb;131(4):461-470
    Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China, china.
    Background: Pravastatin (Pra) exerts protective effects on preeclampsia. Preeclampsia is a multifactorial and pathogenic pathway syndrome. The present study compared the effects of Pra on clinical manifestations of preeclampsia in different pathogenic pathways. Read More

    Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4.
    Chin Med J (Engl) 2018 Feb;131(4):454-460
    Department of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
    Background: MicroRNAs (miRNAs) have been reported to play vital roles in liver regeneration. Previous studies mainly focused on the functions of intracellular miRNAs, while the functions of circulating exosomal miRNAs in liver regeneration remain largely unknown. The aim of this study was to identify the key exosomal miRNA that played vital roles in liver regeneration. Read More

    Identification of Seven Novel Mutations in the Acid Alpha-glucosidase Gene in Five Chinese Patients with Late-onset Pompe Disease.
    Chin Med J (Engl) 2018 Feb;131(4):448-453
    Department of Neurology, Chinese People's Liberation Army General Hospital, Beijing 100853; School of Medicine, Nankai University, Tianjin 300071, China.
    Background: Pompe disease is a rare lysosomal glycogen storage disorder linked to the acid alpha-glucosidase gene (GAA). A wide clinical and genetic variability exists between patients from different ethnic populations, and the genotype-phenotype correlations are still not well understood. The aim of this study was to report the clinicopathological and genetic characteristics of five Chinese patients with late-onset Pompe disease (LOPD) who carried novel GAA gene mutations. Read More

    A Study on Clinical Characteristics and Magnetic Resonance Imaging Manifestations on Systemic Rosai-Dorfman Disease.
    Chin Med J (Engl) 2018 Feb;131(4):440-447
    Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
    Background:: Rosai-Dorfman disease (RDD) is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis. The aim of the current study was to summarize the clinical features and imaging characteristics of RDD, in an effort to improve its diagnostic accuracy.

    Methods: The study was analyzed from 32 patients between January 2011 and December 2017; of these, 16 patients had pathologically diagnosed RDD, eight had pathologically diagnosed meningioma, and eight pathologically diagnosed lymphoma. Read More

    Increased Endogenous Sulfur Dioxide Involved in the Pathogenesis of Postural Tachycardia Syndrome in Children: A Case-Control Study.
    Chin Med J (Engl) 2018 Feb;131(4):435-439
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
    Background: The pathogenesis of postural tachycardia syndrome (POTS) remains unclear. This study aimed to explore the changes and significance of sulfur dioxide (SO) in patients with POTS.

    Methods: The study included 31 children with POTS and 27 healthy children from Peking University First Hospital between December 2013 and October 2015. Read More

    Perioperative Single-Donor Platelet Apheresis and Red Blood Cell Transfusion Impact on 90-Day and Overall Survival in Living Donor Liver Transplantation.
    Chin Med J (Engl) 2018 Feb;131(4):426-434
    Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
    Background:: Although many previous studies have confirmed that perioperative blood transfusion is associated with poor outcomes after liver transplantation (LT), few studies described the influence of single-donor platelet apheresis transfusion in living donor LT (LDLT). This study aimed to assess the effect of blood products on outcomes for LDLT recipients, focusing on apheresis platelets.

    Methods:: This retrospective study included 126 recipients who underwent their first adult-to-adult LDLT. Read More

    Safety and Efficiency of Trabectome-mediated Trabecular Meshwork Ablation for Chinese Glaucoma Patients: A Two-year, Retrospective, Multicentre Study.
    Chin Med J (Engl) 2018 Feb;131(4):420-425
    Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
    Background: The aim of the study was to evaluate the long-term safety and efficacy of the Trabectome for Chinese glaucoma patients.

    Methods: This was a multicenter, retrospective, observational study. Glaucoma patients, except those with neovascular glaucoma, with/without a visually significant cataract were enrolled. Read More

    Patients Administered Neoadjuvant Chemotherapy Could be Enrolled into an Enhanced Recovery after Surgery Program for Locally Advanced Gastric Cancer.
    Chin Med J (Engl) 2018 Feb;131(4):413-419
    Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, China.
    Background: Most studies on enhanced recovery after surgery (ERAS) for gastric cancer exclude patients who received neoadjuvant chemotherapy. Here, we aimed to evaluate whether patients who received neoadjuvant chemotherapy can be enrolled into the ERAS program for locally advanced gastric cancer.

    Methods: From April 2015 to July 2017, 114 patients who received neoadjuvant chemotherapy for locally advanced gastric cancer were randomized into ERAS and standard care (SC) groups. Read More

    Moderate Dose of Trolox Preventing the Deleterious Effects of Wi-Fi Radiation on Spermatozoathrough Reduction of Oxidative Stress Damage.
    Chin Med J (Engl) 2018 Feb;131(4):402-412
    Department of Urology, School of Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
    Background: The worsening of semen quality, due to the application of Wi-Fi, can be ameliorated by Vitamin E. This study aimed to demonstrate whether a moderate dose of trolox, a new Vitamin E, inhibits oxidative damage on sperms in vitro after exposure to Wi-Fi radiation.

    Methods: Each of the twenty qualified semen, gathered from June to October 2014 in eugenics clinic, was separated into four aliquots, including sham, Wi-Fi-exposed, Wi-Fi plus 5 mmol/L trolox, and Wi-Fi plus 10 mmol/L trolox groups. Read More

    Familial Nonmedullary Thyroid Carcinoma: A Retrospective Analysis of 117 Families.
    Chin Med J (Engl) 2018 Feb;131(4):395-401
    Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Background: The first and most important step in characterizing familial nonmedullary thyroid carcinoma (NMTC) is to distinguish the true familial patients, which is the prerequisite for all accurate analyses. This study aimed to investigate whether patients from families with ≥3 first-degree relatives affected with NMTC have different characteristics than patients from families with only two affected members, and to compare these patients with those with sporadic disease.

    Methods:: We analyzed the clinicopathological features and prognosis of 209 familial and 1120 sporadic cases of NMTC. Read More

    Cost Analysis of Cervical Cancer Patients with Different Medical Payment Modes Based on Gamma Model within a Grade A Tertiary Hospital.
    Chin Med J (Engl) 2018 Feb;131(4):389-394
    Department of Medical Administration, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
    Background: Cervical cancer shows a growing incidence and medical cost in recent years that has increased severe financial pressure on patients and medical insurance institutions. This study aimed to investigate the medical economic characteristics of cervical cancer patients with different payment modes within a Grade A tertiary hospital to provide evidence and suggestions for inpatient cost control and to verify the application of Gamma model in medical cost analysis.

    Methods: The basic and cost information of cervical cancer cases within a Grade A tertiary hospital in the year 2011-2016 were collected. Read More

    Associations between Body Composition Indices and Metabolic Disorders in Chinese Adults: A Cross-Sectional Observational Study.
    Chin Med J (Engl) 2018 Feb;131(4):379-388
    Navy Institutional Organization, Beijing 100841, China.
    Background: Obesity induces dyslipidemia, hypertension, glucose intolerance, and inflammatory state, which results in atherogenic processes, diabetes, and cardiovascular disease. We usually use body composition indices, such as body mass index (BMI), body fat percentage (BFP), waist circumference-height ratio (WHtR), and waist-hip ratio (WHR) to reflect the obesity. The aim of this large population-based cross-sectional study was to investigate the associations between body composition indices and metabolic parameters in Chinese adults. Read More

    Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging.
    Chin Med J (Engl) 2018 Feb 5. Epub 2018 Feb 5.
    Department of Radiology, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou, Guangdong 510630, China.
    Objective: Currently, magnetic resonance imaging (MRI) is the most commonly used imaging modality for observing the growth and development of mesenchymal stem cells (MSCs) after in vivo transplantation to treat osteoarthritis (OA). However, it is a challenge to accurately monitor the treatment effects of MSCs in the zone of calcified cartilage (ZCC) with OA. This is especially true in the physiological and biochemical views that are not accurately detected by MRI contrast agents. Read More

    [Evaluation of asthma disease perception from China national asthma control survey].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):467-471
    Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
    In order to evaluate disease perception of asthma patients in urban China and provide evidence for further specific patient education.A multi-center, cross-sectional, questionnaire-based survey was carried out in 30 general hospitals dispersed in 30 provinces of mainland China (except for Tibet) during Oct 2015 to May 2016. Information of disease perception [Question 1: the disease nature of asthma; Question 2: medication choice of first-line in chronic asthma; Question 3: the occasion of using short-acting aerosols of receptor agonists; Question 4: perception of asthma treatment goal; Question 5: reason for not using peak flow meter (PFM)] were collected from asthma patients of outpatient department. Read More

    [Correlation of baseline serum interleukin-6, 10 and its ratio with 7-year all-cause mortality in 11 communities of Beijing].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):460-466
    Peking University Clinical Research Institute, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
    To evaluate whether baseline interleukin-6 (IL-6), interleukin-10 (IL-10) as well as their ratio was associated with overall mortality risk over 7 years of follow-up in 11 communities of Beijing.Data from a prospective cohort study conducted between 2005 and 2012 in 11 communities of Beijing was analyzed to examine the above associations. Serum IL-6 and IL-10 were analyzed using enzyme-linked immunosorbent assay (ELISA) kits. Read More

    [The influence and mechanisms of purple sweet potato anthocyanins on the growth of bladder cancer BIU87 cell].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):457-459
    Department of Urology, Affiliated Taizhou Hospital of Wenzhou Medical University, Linhai 317000, China.
    To observe the effect of purple sweet potato anthocyanins on the proliferation of bladder cancer cell line BIU87 and to investigate the molecular mechanisms.Bladder cancer BIU87 cells were cultured and exposed to anthocyanins at the different concentrations of 100, 200, 400, and 800 μg/ml respectively. The growth inhibition of anthocyanins on BIU87 cells were evaluated by morphometry and cell counting kit-8 (CCK-8) assay, and the cell apoptosis rate was detected by Flow cytometry (FCM). Read More

    [Clinical analysis for preset double J tube in percutaneous nephrolithotripsy].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):454-456
    Department of Urology, the Second Affiliated of Zhejiang University School of Medicine, Hangzhou 310009, China.
    To evaluate the clinical application and effect of preseting Double-J ureteric stent in percutaneous nephrolithotripsy.74 cases of renal calculi treated with PCNL in our hospital during June 2014 to February 2017 were retrospectively analyzed. Of 74 cases, 54 was male, 20 was female. Read More

    [Clinical features of chronic relapsing inflammatory optic neuropathy].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):450-453
    Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
    To explore the clinical characteristics and prognosis of chronic relapsing inflammatory optic neuropathy (CRION).A retrospective analysis was conducted. Clinical features, disease course, prognosis and magnetic resonance imaging (MRI) of patients with CRION who were admitted to Department of Neurology between 2014 and 2016 were reviewed and analyzed. Read More

    [Clinical features and gene analysis of TBC1D24 gene mutation related early-onset focal myoclonic epilepsy].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):445-449
    Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
    To investigate the clinical features and genetic characteristics of patients with TBC1D24 gene mutation related early-onset focal myoclonic epilepsy.Clinical data of 3 patients with TBC1D24 gene mutation related early-onset focal myoclonic epilepsy of Xuanwu Hospital from November 2016 to June 2017 was collected and analyzed.Candidate gene mutations were screened by second generation sequencing. Read More

    [Prevalence and risk factors of diabetic retinopathy in hospital patients].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):440-444
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients.A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. Read More

    [A study of the relations of foramen rotundum structure direction and the approach of percutaneous puncturing of radiofrequency thermocoagulation for treating V2 of primary trigeminal neuralgia].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):436-439
    Department of Anesthesiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310000, China.
    To investigate the relations of foramen rotundum structure direction and surrounding structure systematically in order to choose the best approach of percutaneous puncturing of radiofrequency thermocoagulation for treating V2 of primary trigeminal neuralgia.A total of 122 patients with V2 of primary trigeminal neuralgia for radiofrequency thermocoagulation were enrolled from August 2012 to May 2017 at the First Hospital of Jiaxing. CT scan images were observed retrospectively, to find the inside and outside of the foramen rotundum. Read More

    [Evaluation of the diagnosis value of carcinoembryonic antigen in malignant pleural effusion].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):432-435
    Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing 100020, China.
    To investigate the diagnostic value of serum and pleural fluid carcinoembryonic antigen (CEA) for malignant pleural effusion (MPE).The concentration of CEA in serum and pleural fluid of 286 patients with the diagnosis confirmed by pleural biopsy through medical thoracoscopy were retrospectively analyzed. MPE was confirmed in 171 cases which were divided into two groups (adenocarcinoma group with 121cases and non-adenocarcinoma group with 50 cases) and benign pleural effusion in 115 cases. Read More

    [Diagnostic significance of serum free DNA human telomerase reverse transcriptase quantitative determination on spinal cord injury].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):427-431
    Department of Orthopaedics, Tongjiang New District Hospital, Bazhong 636000, China.
    To investigate the relationship between the content of human telomerase reverse transcriptase (hTERT) and its clinical features in serum free DNA in patients with different degree of spinal cord injury.From December 2013 to December 2016, inpatients of the Central Hospital of Bazhong, Sichuan Province were enrolledand divided into the experimental group, the disease control group and the negative control group. For the experimental group: 46 patients with spinal cord injury were graded according to the criteria of the American Association of Spinal Cord Injury (ASIA), including 12 cases of grade A, 10 cases of grade B, 10 cases of grade C, 7 cases of grade D and 7 cases of grade E; for the disease control group: 15 patients with spinal fractures (without spinal cord injury) at the same period were included; and for the negative control group: 20 healthy adult volunteers aged 18-50 years were selected. Read More

    [Long-term follow-up of C(1)-C(2) pedicle screw fixation for pediatric atlantoaxial dislocation].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):422-426
    Department of Orthopedics, the 175th Hospital of PLA, the Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, China.
    To investigate the clinical curative effect of C(1)-C(2) pedicle screw fixation for pediatric atlantoaxial dislocation after a long-term follow-up.From March 2005 to April 2011, a total of 12 male and 9 female patients were included, with age from 3 to 9 years old (mean, 6.1 years old). Read More

    [Comparison of the pulmonary function between adolescent patients with Chiari malformation associated scoliosis and idiopathic scoliosis].
    Zhonghua Yi Xue Za Zhi 2018 Feb;98(6):418-421
    Department of Spinal Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China.
    To compare the pulmonary function between adolescent patients with Chiari malformation associated scoliosis (CMS) and adolescent idiopathic scoliosis (AIS).A retrospective analysis was performed on 52 patients with CMS, and 52 patients with AIS were selected as the control group to match the CMS patients by age, sex, and Cobb angle. Preoperative pulmonary function tests were completed by all the patients, including vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV(1)), maximal mid-expiratory flow (MMEF), and ratio of FEV(1) to FVC. Read More

    [The roles of IL-17 and CXCR4 in chronic allograft nephropathy in rat models].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):370-373
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
    To investigate the role and mechanism of IL-17 and CXCR4 in chronic graft nephropathy (CAN) in rat models.CAN rat models were established using Fisher 344 to Lewis rats. In the control group(=10), Lewis rats were performed isotransplantation. Read More

    [Clinical analysis of multiple myeloma-associated amyloidosis].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):365-369
    Department of Hematology and Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China.
    To investigate the clinical features and survival of multiple myeloma-associated amyloidosis patients.Twenty three multiple myeloma-associated amyloidosis patients were retrospectively analyzed from January 2009 to December 2016.The overall response rate(ORR)was 65. Read More

    [Clinical research on acute paraplegia resulting from intrathecal chemotherapy].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):362-364
    Department of Neurology, Peking University People's Hospital, Beijing 100044, China.
    To investigate the potential pathogenesis of acute paraplegia resulting from intrathecal chemotherapy and to analyze the factors influencing prognosis.Six cases presented with acute paraplegia after intrathecal chemotherapy for leukemia from January 1(st,) 2015 to June 1(st,) 2017 in our hospital. The patients' clinical manifestation, data of imaging and cerebrospinal fluid were analyzed. Read More

    [Comparative study of proximal femoral nail anti-rotation and dynamic hip screw in the unstable intertrochanteric fractures in the elderly].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):357-361
    Department One of Orthopedics, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
    To compare the effect of proximal femoral nail anti-rotation and dynamic hip screw in treating the femoral intertrochanteric fractures in elderly patients.From June 2011 to June 2014, totally 158 elderly patients of femoral intertrochanteric fracture were treated by surgery, among whom 68 cases were treated with dynamic hip screws (DHS), and 90 patients were treated with proximal femoral nail anti-rotation (PFNA). The operative time, hospitalization time, weight-bearing time, fracture-healing time, blood loss and the hip function score after the operation were compared between the two groups by using thetest; and the incidence of the postoperative complication was compared between the two groups by using the Chi square test. Read More

    [Effects of expanded anterolateral approach for tibial plateau fractures involved the posterolateral column].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):352-356
    Department of Traumatic Orthopaedics, the First Affiliated Hospital of Wannan Medical College, Wuhu 241001, China.
    To explore the short-term effects of expanded anterolateral approach in treating fracture involved the posterolateral tibial plateau.A retrospective analysis of the clinical data from 16 patients undergoing extended anterolateral approach for fracture involved the posterolateral tibial plateau in the First Affiliated Hospital of Wannan Medical College between January 2013 and July 2016 was done. The patients were treated with 3. Read More

    [Assessment of renal function with intravoxel incoherent motion and diffusion tensor imaging in type 2 diabetic patients].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):346-351
    Medical School of Southeast University, Nanjing 210009, China.
    To evaluate the application value of intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) in detecting early-stage diabetic nephropathy and to assess the damage of ralated renal function.A total of 52 patients with type 2 diabetes diagnosed in Zhongda Hospital were collected from April 2016 to May 2017 and were assigned to DM group (diabetes without nephropathy,=32) and DN group (diabetes with nephropathy,=20) according to detection of microalbuminuria, a cohort of healthy recipients were included as control group (=27) in the meantime. All of the subjects underwent IVIM and DTI examination. Read More

    [Experimental studies on correlation between nucleolus spindle-related protein 1 and the malignant progression and prognosis of human glioblastoma multiforme].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):340-345
    Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
    To investigate the correlation between nucleolus spindle-related protein 1 (NUSAP1) and malignant progression and prognosis of human glioblastoma multiforme (GBM).RT-PCR and immunohistochemical technique were applied to analyze NUSAP1 expression level in GBM surgical specimens. Correlations between NUSAP1 expression and molecular classification and survival of patients with GBM were also investigated in TCGA database. Read More

    [The changes of plasma coagulation function in patients with glioma and its correlation with malignant grade of glioma].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):336-339
    Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300350, China.
    To investigate the changes of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time(TT), fibrinogen(FIB) and platelet counts(PLT) in plasma of patients with glioma, and to explore the correlations between PT, APTT, TT, FIB and PLT with malignant grades of glioma.One hundred and seventy-two patients with glioma and 47 health controls were investigated in a retrospective analysis. All patients were diagnosed and identified the WHO grade by pathologist after operation. Read More

    [Prognostic significance of neoplastic central nervous system tumor classification for patients with low grade glioma].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):332-335
    Department of Neurosurgery, First Hospital of Tsinghua University, Beijing 100016, China.
    To explore the prognostic impact of 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors on patients with low grade gliomas (LGG).A total of 482 patients diagnosed with LGG in Beijing Tiantan Hospital affiliated to Capital Medical University from January 2009 to May 2016 were pathologically reclassified and retrospectively reviewed. In the survival analysis, Kaplan-Meier Plot was used to univariate analysis and Cox proportional hazards model was used to multivariate analysis. Read More

    [The research of the innate defense regulator peptide on the effects of methicillin resistant staphylococcus aureus biofilm].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(4):294-298
    Department of Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China(is now working in General ICU of Zhengzhou Central Hospital Affiliated to Zhengzhou University).
    To investigate the destruction of the mature biofilm and the inhibitory effect of the biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) by different concentrations of the innate defense regulatory peptide (IDR-1018).1 ×10(5)CFU /ml MRSA was inoculated uniformly into 96 well plates, the biofilm model would be completed after 48 h. Given the different concentration of IDR-1018 solution as the experimental group double diluted with tryptic soy broth (TSB), the concentration in bacteria suspension reached 3. Read More

    [Relationship between C-C chemokine receptor type 2 and P38 mitogen-activated protein kinase signaling pathway in the spinal cord of rats with bone cancer pain].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(4):289-293
    Department of Anesthesiology, Bengbu Medical College, Bengbu 233030, China.
    To investigate the relationship between C-C chemokine receptor type 2(CCR2) and P38 mitogen-activated protein kinase (P38MAPK) signaling pathway in the spinal cord of rats and further clarify the mechanism of bone cancer pain (BCP).A total of 92 healthy female SD rats, of which 60 were subjected to behavioral tests using a ciliary mechanical stimulation needle. SD rats were randomly divided into six groups: sham operation group (group S), bone cancer pain group (group B), sham operation + DMSO solvent group (group SD), bone cancer pain + DMSO solvent group (group BD), sham operation + RS102895 CCR2 inhibitor group (group SR), bone cancer pain + RS102895 CCR2 inhibitor group (group BR), and Von Frey was used in the behavioral test. Read More

    [Clinical features and gene mutation analysis of patients with Niemann-Pick disease type C].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(4):284-288
    Department of Pediatric, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China.
    To analyze the clinical manifestations, therapeutic efficacy, prognosis and characteristics of NPC1 mutation in Chinese patients with Niemann-Pick disease type C(NPC).Ten unrelated Chinese NPC patients were diagnosed by NPC1 mutation analysis from July 2013 to February 2017 in Beijing Tian Tan Hospital of Capital Medical University. Clinical data of 10 cases were analyzed retrospectively which included clinical manifestations, laboratory results and NPC1 gene mutation features, and a series of follow-up were carried out about therapeutic efficacy and prognosis. Read More

    [Analysis of clinical characteristics of paraganglioma in 42 patients].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(4):280-283
    Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.
    To summarize the clinical characteristics of paraganglioma.A total of 215 pheochromocytoma/ paraganglioma cases in Peking University First Hospital between January 1996 and December 2014 were retrospectively analyzed. The patients were divided into two groups according to the tumor position: pheochromacytoma group (173 patients) and paraganglioma group (42 patients). Read More

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