[Effects of human mesenchymal stem cells on airway inflammation in allergic asthma mice and the underlying mechanism].
Zhonghua Yi Xue Za Zhi 2017 Sep;97(34):2697-2702
Guangdong Online Hospital, Guangdong 2nd Provincial People's Hospital, Guangzhou 510317, China.
Objectives: To investigate the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on airway inflammation in an ovalbumin (OVA) induced asthma mouse model and the underlying mechanism. Methods: Twenty-four BALB/c mice were randomly divided into four equal groups: normal control group, OVA-induced asthmatic model group, hUC-MSCs treated group (50 μl of hUC-MSCs was transplanted into the trachea of asthmatic mice ) and hUC-MSCs control group (50 μl of hUC-MSCs was transplanted into the trachea of control mice). Human umbilical cord mesenchymal stem cells from umbilical cord of healthy new born babies were used as the source of hUC-MSCs for this study. Read More