2,017 results match your criteria Chinese journal of integrative medicine[Journal]


Analysis on Situation of Traditional Chinese Medicine Development and Protection Strategies in China.

Authors:
Hui Liu Zhi-Guo Ma

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Intellectual Property Research Center, School of Law, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.

With the worldwide growing interest and commercial value of traditional Chinese medicine (TCM) industries and products, the protection issue of TCM knowledge is increasingly concerned by Chinese government. Here, we investigated the current situation and trend of TCM development and knowledge protection in China through accessing academic research tools including China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP China Science and Technology Journal Database (VIP) and Google Scholar, analyzing the latest data released by National Administration of Traditional Chinese Medicine, China Statistical Yearbook of Chinese Medicine and China Statistical Yearbook. Our results demonstrate that current administration in China is continuing to support TCM development by increasing investment and expanding the scale in TCM research and administration. Read More

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http://dx.doi.org/10.1007/s11655-020-3218-0DOI Listing

Danlou Tablet () Improves Chronic Intermittent Hypoxia-induced Dyslipidemia and Arteriosclerosis by HIF-1 α-Angptl4 mRNA Signaling Pathway.

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Objective: To detect whether Danlou Tablet (, DLT) regulates the hypoxia-induced factor (HIF)-1 α-angiopoietin-like 4 (Angptl4) mRNA signaling pathway and explore the role of DLT in treating chronic intermittent hypoxia (CIH)-induced dyslipidemia and arteriosclerosis.

Methods: The mature adipocytes were obtained from 3T3-L1 cell culturation and allocated into 8 groups including control groups (Groups 1 and 5, 0.1 mL of cell culture grade water); DLT groups (Groups 2 and 6, 0. Read More

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http://dx.doi.org/10.1007/s11655-020-3255-8DOI Listing

Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial.

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Persian Traditional Medicine, Faculty of Persian Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, 9177899191, Iran.

Objective: To evaluate the efficacy and safety of administration of the formulated Persian herbal syrup on improving the symptoms of patients with constipation-predominant irritable bowel syndrome (IBS-C).

Methods: This study was conducted in 70 patients with IBS-C, who were recruited from 3 medical centers in Mashhad, Iran, from November 2017 to August 2018. Seventy patients were randomly assigned to 2 groups including treatment and placebo groups by block randomization, 35 cases in each group. Read More

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http://dx.doi.org/10.1007/s11655-020-3267-4DOI Listing

Tanreqing Injection () for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Emergency Department of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.

Objective: To systematically evaluate the efficacy and safety of Tanreqing Injection (, TRQI) combined with conventional treatment on clinical outcomes in the treatment of patients with influenza.

Methods: The electronic databases searched were Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE (PubMed), EMbase (OvidSP), Chinese Bio-medical Literature and Retrieval System (Sinomed), China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP) and WanFang Data Knowledge Service Platform, and we checked the reference sections of the retrieved articles as well. The search was performed in October 2018, and we used the randomized controlled trials (RCTs) that corresponded to the new diagnostic criteria for influenza. Read More

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http://dx.doi.org/10.1007/s11655-020-3472-1DOI Listing

Exploring Mechanism of Key Chinese Herbal Medicine on Breast Cancer by Data Mining and Network Pharmacology Methods.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Oncology and Haematology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province, 518033, China.

Objective: To screen the key Chinese Herbal Medicines (KCHMs) against breast cancer by data mining, and analyze the potential mechanism of KCHMs using network pharmacology method.

Methods: Clinical prescriptions consisted of CHMs for treating breast cancer were screened, and then Traditional Chinese Medicine Inheritance Support System (TCMISS) was applied to obtain the KCHMs. Subsequently, active ingredients and corresponding target genes of KCHMs were searched by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database, and target genes of breast cancer were collected using OMIM and MalaCards. Read More

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http://dx.doi.org/10.1007/s11655-020-3422-yDOI Listing

Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Reproductive and Genetic Center of Integrated Traditional and Western Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, China.

Objective: To evaluate the effect of electro-acupuncture (EA) in infertile patients with phlegm-dampness polycystic ovary syndrome-insulin resistance (PCOS-IR).

Methods: Seventy-six PCOS-IR patients who underwnet in vitro fertilization and embryo transfer (IVF-ET) were equally assigned to two groups according to a random digital table: the EA group and the control group, with 38 cases in each group. Before undergoing IVF, the two groups were treated with EA or pseudo-acupuncture, respectively, for 3 menstrual cycles. Read More

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http://dx.doi.org/10.1007/s11655-020-3219-zDOI Listing

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.

Objective: To determine the effectiveness and safety of essential oil from Citrus aurantium on anxiety in patients undergoing coronary angiography.

Methods: A single-blind, randomized controlled trial was conducted in 80 patients experiencing coronary angiography in Imam Ali Hospital in Kermanshah, Iran from April to November in 2016. All patients were randomly divided into intervention and control groups by a random number table, 40 cases in each group. Read More

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http://dx.doi.org/10.1007/s11655-020-3266-5DOI Listing

Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Cardiovascular Disease, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Objective: To evaluate the protective effects of salvianolate on percutaneous coronary intervention (PCI) related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients.

Methods: A total of 149 patients with NSTE-ACS who underwent elective PCI were enrolled. The patients were randomly allocated in a 1:1 ratio to the salvianolate group (74 cases) or the control group (75 cases). Read More

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http://dx.doi.org/10.1007/s11655-020-2728-0DOI Listing

Treatment of HBV Cirrhosis with Fuzheng Huayu Tablet () and Entecavir: Design of a Randomized, Double-Blind, Parallel and Multicenter Clinical Trial.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Background: Antiviral therapy can lead to regression of fibrosis in chronic hepatitis B (CHB), but it has a limited effect on cirrhosis. Chinese medicines (CMs), particularly Fuzheng Huayu Tablet (, FZHY), have an antifibrotic effect in patients with CHB.

Objective: To observe the safety and efficacy of adjunctive FZHY in patients with hepatitis B virus (HBV) cirrhosis, this study was designed as a randomized, placebo-controlled, double-blind, parallel assignment, multicenter trial at 20 centers in China. Read More

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http://dx.doi.org/10.1007/s11655-020-3257-6DOI Listing

Antidepressant-Like Effects of Chaihu Shugan Powder () on Rats Exposed to Chronic Unpredictable Mild Stress through Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, 518020, China.

Objective: To investigate the antidepressant-like effects of Chaihu Shugan Powder (CSP, ) and to explore its underlying mechanisms.

Methods: Thirty-two Sprague-Dawley rats were randomly divided into control (CON), chronic unpredictable mild stress (CUMS), fluoxetine (FLU), and CSP groups, 8 rats in each group. All of the rats except for those in the control group were subjected to 3 consecutive weeks of CUMS to establish the depression model. Read More

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http://dx.doi.org/10.1007/s11655-020-3228-yDOI Listing

Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600025, India.

Objective: To examine the role of carvacrol in modulating PI3K/AKT signaling involved in human breast cancer pathogenesis using in vitro experimental model MCF-7 cells.

Methods: MTT and lactate dehydrogenase assays were performed with cells treated with different doses of carvacrol (0-250 p mol/L) at different time points (24 and 48 h). The nuclear morphology was assessed in MCF-7 cells with propidium iodide (PI) and acridine orange/ethidium bromide (AO/EB) staining and analyzed by fluorescence microscopy. Read More

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http://dx.doi.org/10.1007/s11655-020-3193-5DOI Listing

Cupping Therapy for Diseases: An Overview of Scientific Evidence from 2009 to 2019.

Chin J Integr Med 2020 Jun 10. Epub 2020 Jun 10.

Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Cupping therapy has been accepted worldwide, and many studies have been conducted to reveal its curative effects and mechanisms. To comprehensively evaluate the effect of cupping therapy, database including China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database VIP, Wan Fang Database, Chinese Biomedicine (CBM), PubMed and Web of Science were searched from 2009-2019. We summarized all the meta-analyses, randomized controlled trials, clinical trials and the mechanisms studies of cupping therapy in the previous 10 years, hoping to provide a reference for the clinical applications and studies. Read More

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http://dx.doi.org/10.1007/s11655-020-3060-yDOI Listing

Intestinal Microecology: An Important Target for Chinese Medicine Treatment of Non-alcoholic Fatty Liver Disease.

Chin J Integr Med 2020 Jun 10. Epub 2020 Jun 10.

Institute of Liver Disease, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, causing serious economic and medical burdens. Currently, Chinese medicine (CM) has become an important means in treating NAFLD in China. Intestinal microecology (IM) is an important part of the internal environment in the human body and is involved in the occurrence and development of NAFLD. Read More

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http://dx.doi.org/10.1007/s11655-020-3268-3DOI Listing

Protective Mechanisms of Suxiao Jiuxin Pills () on Myocardial Ischemia-Reperfusion Injury in vivo and in vitro.

Chin J Integr Med 2020 Jun 10. Epub 2020 Jun 10.

AMI Key Laboratory of Chinese Medicine in Guangzhou, Guangdong Province Hospital of Chinese Medicine, the 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Science, Guangzhou, 510006, China.

Objective: To study the protective mechanism of Chinese medicine Suxiao Jiuxin Pills (, SXJ) on myocardial ischemia and reperfusion (I/R) injury.

Methods: Mouse myocardial I/R injury model was created by 30-min coronary artery occlusion followed by 24-h reperfusion, the mice were then divided into the sham group (n=7), the I/R group (n=13), the tirofiban group (TIR, positive drug treatment, n=9), and the SXJ group (n=11). Infarct size (IS), risk region (RR), and left ventricle (LV) were analyzed with double staining methods. Read More

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http://dx.doi.org/10.1007/s11655-020-2726-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283981PMC

Chinese Medicine Treatment Prolonged Survival in Small Cell Lung Cancer Patients: A Clinical Observation.

Chin J Integr Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.

Objective: To evaluate the effect of Chinese medicine (CM) treatment on survival time and quality of life (QOL) in patients with small cell lung cancer (SCLC).

Methods: This was an exploratory and prospective clinical observation. Patients diagnosed with SCLC receiving CM treatment were included and followed up every 3 months. Read More

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http://dx.doi.org/10.1007/s11655-020-3197-1DOI Listing

Botanical Therapeutics for Parkinson's Disease.

Authors:
Wen-Wei Li

Chin J Integr Med 2020 Jun 31;26(6):405-411. Epub 2020 May 31.

Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201500, China.

Parkinson's disease (PD) was first formally described by James Parkinson in 1817, but the shaking of limbs was described in the literature of several ancient civilizations, such as ancient Chinese civilization and ancient Indian civilization. Historically, botanical drugs were used as the main source for the treatment of such kind of disorders. In Western countries, plant extracts also occupied an important place in the earlier medications of PD. Read More

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http://dx.doi.org/10.1007/s11655-020-3096-5DOI Listing
June 2020
1.401 Impact Factor

Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via a Network Pharmacology Approach.

Chin J Integr Med 2020 May 22. Epub 2020 May 22.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.

Objective: To investigate the shared mechanisms of scutellarin in angina pectoris (AP) and ischemic stroke (IS) treatment.

Methods: A network pharmacology approach was used to detect the potential mechanisms of scutellarin in AP and IS treatment by target prediction, protein-protein interaction (PPI) data collection, network construction, network analysis, and enrichment analysis. Furthermore, molecular docking simulation was employed to analyze the interaction between scutellarin and core targets. Read More

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http://dx.doi.org/10.1007/s11655-020-2716-4DOI Listing

Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder.

Chin J Integr Med 2020 May 22. Epub 2020 May 22.

Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul, 07985, Republic of Korea.

Objective: Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by depression and anxiety, that arises due to an imbalance of neurotransmitters in response to excessive stress. Hesperidin (HSD) is a naturally occurring flavonoid shown to exert a variety of biological activities, including antioxidant, anti-inflammatory, and neuroprotective effects.

Methods: This study was used the open field test (OFT) and forced swimming test (FST) to examine the effects of HSD on the depression-like response of rats after exposure to a single prolonged stress (SPS) leading to the dysregulation of the serotonergic activation system. Read More

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http://dx.doi.org/10.1007/s11655-020-2724-4DOI Listing

Status Quo and Analysis of the Cardiovascular Clinical Practice Guidelines/Expert Consensuses of Chinese and Integrative Medicine: A Systematic Review.

Chin J Integr Med 2020 May 22. Epub 2020 May 22.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.

Objective: To describe and analyze the status quo of cardiovascular clinical practice guidelines or expert consensuses including both Chinese medicine (CM) and integrative medicine, through systematic literatures searching and quality assessment.

Methods: Data bases including Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, Wanfang Data, China Science and Technology Journal Database were searched for published CM or integrative cardiovascular clinical practice guidelines or expert consensuses. The website www. Read More

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http://dx.doi.org/10.1007/s11655-020-2725-3DOI Listing
May 2020
1.401 Impact Factor

Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model.

Chin J Integr Med 2020 May 15. Epub 2020 May 15.

Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, 94121, USA.

Objective: To determine whether topical applications of thiosulfinate-enriched Allium sativum extract (TASE) can accelerate acute cutaneous wound healing (WH) in a murine model.

Methods: Keratinocyte viability and in vitro wound closure were assessed in keratinocyte cultures. Effects of topical TASE (0. Read More

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http://dx.doi.org/10.1007/s11655-020-3086-7DOI Listing

Opposite Modulatory Effects of Crataegus aronia Aqueous Extract on Platelet Aggregation in Rats.

Chin J Integr Med 2020 May 16. Epub 2020 May 16.

Department of Physiology, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 11481, Saudi Arabia.

Objectives: To reveal the mechanisms behind the dual effects of Crataegus aronia (C. aronia) aqueous extract on platelet aggregation by focusing on function, regulation, expression, and signaling of platelets PY receptors.

Methods: Adult male Wistar rats (120 ± 10 g) were classified as control received the vehicle, C. Read More

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http://dx.doi.org/10.1007/s11655-020-3187-3DOI Listing

Early Intervention of Tongxinluo () on Right Ventricular Function Assessed by Echocardiography in Rats with Pulmonary Arterial Hypertension Induced by Monocrotaline.

Chin J Integr Med 2020 May 16. Epub 2020 May 16.

Department of Traditional Chinese Medicine, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.

Objective: To investigate the effect of early intervention of Tongxinluo (, TXL) on right ventricular function (RVF) of rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT).

Methods: A total of 30 adult male Sprague-Dawley rats were assigned to 5 groups with complete random experiment design: Sham group (Sham), MCT group, TXL group, sildenafil (SIL) group and combination group (TXL+SIL), 6 rats in each group. Rats were injected with 50 mg/kg MCT solution for inducing PAH model except for those in the sham group. Read More

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http://dx.doi.org/10.1007/s11655-020-3229-xDOI Listing

Banxia Xiexin Decoction () Treats Diabetic Gastroparesis through PLC-IP-Ca/NO-cGMP-PKG Signal Pathway.

Chin J Integr Med 2020 May 16. Epub 2020 May 16.

Department of Gastroenterology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.

Objective: To test the effect of Banxia Xiexin Decoction (, BXD) on the contraction and relaxation of gastric smooth muscle (SM) in diabetic gastroparesis (DGP) model rats, and to explore the mechanism of BXD in the prevention and treatment of DGP through experiments of signal pathway both in vivo and in vitro.

Methods: Sixty Sprague-Dawley rats were divided into 6 groups according to a random number table: control group, model group, high-, medium- and low-dose BXD groups (9.2, 4. Read More

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http://dx.doi.org/10.1007/s11655-020-3077-8DOI Listing

Panax quinquefolium saponin Optimizes Energy Homeostasis by Modulating AMPK-Activated Metabolic Pathways in Hypoxia-Reperfusion Induced Cardiomyocytes.

Chin J Integr Med 2020 May 16. Epub 2020 May 16.

Center for Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Objective: To investigate the effects and underlying mechanisms of Panax quinquefolium saponin (PQS) on energy deficiency in hypoxia-reperfusion (H/R) induced cardiomyocytes.

Methods: The H/R injury involved hypoxia for 3 h and then reperfusion for 2 h. Cardiomyocytes recruited from neonatal rat ventricular myocytes (NRVMs) were randomly divided into control, H/R, H/R+compound C (C. Read More

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http://dx.doi.org/10.1007/s11655-020-3194-4DOI Listing

Realgar (α-AsS) Treats Myelodysplasic Syndromes through Reducing DNA Hypermethylation.

Chin J Integr Med 2020 May 16. Epub 2020 May 16.

Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences and Beijing Key Lab of Traditional Chinese Medicine Pharmacology, Beijing, 100091, China.

DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes (MDS). Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes, inducing gene silencing. Realgar (α-AsS) is a traditional medicine used for the treatment of various diseases in the ancient time. Read More

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http://dx.doi.org/10.1007/s11655-020-3263-8DOI Listing

Effect Evaluation of Strychnos nux-vomica L. with Integrative Methods for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma Patients: A Self-Controlled Clinical Trial.

Chin J Integr Med 2020 May 16. Epub 2020 May 16.

Department of Hematology, The First Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310006, China.

Objective: To explore the clinical effect and adverse reactions of Strychnos nux-vomica in bortezomib-induced peripheral neuropathy (BIPN) of patients with multiple myeloma (MM).

Methods: A total of 19 MM patients with BIPN were enrolled and Nux Vomica Capsule (NVC, 0.4 g, thrice daily) were orally administrated for 30 days. Read More

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http://dx.doi.org/10.1007/s11655-020-3196-2DOI Listing

Xueshuantong for Injection (Lyophilized, ) Alleviates Streptozotocin-Induced Diabetic Retinopathy in Rats.

Chin J Integr Med 2020 May 15. Epub 2020 May 15.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

Objective: To investigate the ameliorate effect and underlying mechanism of Xueshuantong for Injection (Lyophilized, , XST) in streptozocin (STZ)-induced diabetic retinopathy (DR) rats.

Methods: Diabetes mellitus (DM) model was induced by intraperitoneal (i.p. Read More

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http://dx.doi.org/10.1007/s11655-020-3088-5DOI Listing

Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis.

Chin J Integr Med 2020 May 15. Epub 2020 May 15.

Department of Scientific Research, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Objective: To evaluate the effect and safety of cinnamaldehyde on immunosuppressed mice with invasive pulmonary candidiasis.

Methods: An immunosuppressed BALB/c mouse model was established by intraperitoneal administration of cyclophosphamide (200 mg/kg) once daily for 2 days. The immunosuppressed mouse with invasive pulmonary candidiasis model was further established by nasal perfusion of Candida albicans suspension. Read More

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http://dx.doi.org/10.1007/s11655-020-3075-xDOI Listing

Usage of Chinese Herbs in Cancer Patients in Southern China: A Survey.

Chin J Integr Med 2020 May 9. Epub 2020 May 9.

Department of Oncology, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405, China.

Objective: To study the use of Chinese medicine (CM) in cancer patients in southern China.

Methods: A total of 1,950 cancer patients finished questionnaires in four provinces in southern China. The survey included socio-demographic and clinical characteristics of participants, dosage forms, efficacy, and side effects. Read More

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http://dx.doi.org/10.1007/s11655-019-3184-6DOI Listing

Network Pharmacology-Based Exploration of Synergistic Mechanism of Guanxin II Formula (II) for Coronary Heart Disease.

Chin J Integr Med 2020 May 9. Epub 2020 May 9.

Emergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Objective: To study the pharmacological mechanism of Guanxin II formula (II) for treatment of coronary heart disease (CHD).

Methods: A network pharmacology-based method was utilized. First candidate compounds, targets of GX II were collected using PharmMapper, BATMAN-TCM, DrugBank and SwissTargetPrediction, and targets on CHD were mined from GeneCards, DisGenet, DrugBank and GEO. Read More

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http://dx.doi.org/10.1007/s11655-020-3199-zDOI Listing

Effects of Three Needling Manipulations of Zusanli (ST 36) on Deqi Sensations and Surface Myoelectricity in Healthy Participants.

Chin J Integr Med 2020 May 9. Epub 2020 May 9.

Department of Needling Manipulation, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Objective: To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity, and explore the correlation between Deqi sensations and needling manipulations.

Methods: Forty-five healthy participants accepted twirling, lifting-thrusting, and twirling plus lifting-thrusting manipulanions at right Zusanli (ST 36), respectively. The acupuncturist's and participants' Deqi sensations were collected by MGH Acupuncture Sensation Scale (MASS). Read More

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http://dx.doi.org/10.1007/s11655-020-3198-0DOI Listing

Traditional Chinese and Western Medicines Jointly Beat COVID-19 Pandemic.

Chin J Integr Med 2020 06 2;26(6):403-404. Epub 2020 May 2.

Center of Smart Laboratory and Molecular Medicine, Medical School of Chongqing University, Chongqing, 400044, China.

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http://dx.doi.org/10.1007/s11655-020-3095-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195906PMC

Effect and Safety of Hydroxysafflor Yellow A for Injection in Patients with Acute Ischemic Stroke of Blood Stasis Syndrome: A Phase II, Multicenter, Randomized, Double-Blind, Multiple-Dose, Active-Controlled Clinical Trial.

Chin J Integr Med 2020 Jun 2;26(6):420-427. Epub 2020 May 2.

Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.

Objective: To assess the effect and safety of Hydroxysafflor Yellow A for Injection (HSYAI) in treating patients with acute ischemic stroke (AIS) and blood stasis syndrome (BSS).

Methods: A multicenter, randomized, double-blind, multiple-dose, active-controlled phase II trial was conducted at 9 centers in China from July 2013 to September 2015. Patients with moderate or severe AIS and BSS were randomly assigned to low-, medium-, high-dose HSYAI groups (25, 50 and 70 mg/d HSYAI by intravenous infusion, respectively), and a control group (Dengzhan Xixin Injection (, DZXXI) 30 mL/d by intravenous infusion), for 14 consecutive days. Read More

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http://dx.doi.org/10.1007/s11655-020-3094-7DOI Listing
June 2020
1.401 Impact Factor

Research on Function and Mechanism of Tai Chi on Cardiac Rehabilitation.

Chin J Integr Med 2020 May 29;26(5):393-400. Epub 2020 Apr 29.

Department of Rehabilitation, Acupuncture and Moxibustion and Massage College • Health Preservation and Rehabilitation College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

With the increasing number of cardiovascular patients, more and more people are living with diseases. Cardiac rehabilitation (CR) is an effective treatment and prevention measure for cardiovascular disease (CVD), which aims to relieve both psychological and physiological stress of CVD, reduce risk of death from CVD, improve cardiovascular function and patients' quality of life. Tai Chi is popular in China and mainly used as a daily leisure activity for the elderly to strengthen their bodies. Read More

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http://dx.doi.org/10.1007/s11655-020-3262-9DOI Listing
May 2020
1.401 Impact Factor

Chinese Medicine Treatment on Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

Chin J Integr Med 2020 May 29;26(5):324-329. Epub 2020 Apr 29.

Institute of Hematology Research, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China.

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic stem cell transplantation, and also an important factor affecting the survival and quality of life in patients after transplantation. Currently, immunosuppressive therapy is commonly used for GVHD, but the curative effect is not ideal. How to effectively prevent and treat GVHD is one of the difficulties to be solved urgently in the field of transplantation. Read More

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http://dx.doi.org/10.1007/s11655-020-3252-yDOI Listing

Effect of Tongguan Capsules () on Restenosis after Coronary Stent Implantation: Study Protocol for A Randomized Controlled Trial.

Chin J Integr Med 2020 Apr 24. Epub 2020 Apr 24.

Key Discipline of Integrated Traditional Chinese and Western Medicine, Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.

Background: Although percutaneous coronary intervention (PCI) had become widely employed therapeutic procedure for coronary artery disease, stent restenosis limited the benefits of this revascularization and the question how to prevent such events remained unresolved. While numerous empirical observations suggested Tongguan Capsules (), a patented Chinese Medicine, could decrease frequency and duration of angina pectoris attacks, evidence supporting its efficacy on restenosis remained inadequate.

Objective: This trial was designed to determine whether Tongguan Capsules would reduce restenosis rate in patients after successful stent implantation. Read More

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http://dx.doi.org/10.1007/s11655-020-2722-6DOI Listing

Saposhnikovia divaricata-An Ethnopharmacological, Phytochemical and Pharmacological Review.

Chin J Integr Med 2020 Apr 21. Epub 2020 Apr 21.

Department of Pharmacy, Baotou Medical College, 014060, Baotou, Inner Mongolia Autonomous Region, China.

Saposhnikovia divaricata (Turcz.) Schischk., a perennial herb belonging to the family Umbelliferae, is widely distributed in Northeast Asia. Read More

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http://dx.doi.org/10.1007/s11655-020-3091-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176574PMC

Mechanisms of Electroacupuncture on Alzheimer's Disease: A Review of Animal Studies.

Chin J Integr Med 2020 Jun 21;26(6):473-480. Epub 2020 Apr 21.

College of Acupuncture and Massage, College of Regimen and Rehabilitation, Nanjing University of Traditional Chinese Medicine, Nanjing, 210023, China.

Alzheimer's disease (AD) is the main type of dementia affecting elderly people. The medicines used for treating AD have limits in their ability to alleviate cognitive and functional decline. Electroacupuncture (EA), an economical alternative and complementary therapeutic measure used in Chinese medicine, has strong clinical applicability, and its treatment effects are more reliable as its stimulation factors can be standardized. Read More

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http://dx.doi.org/10.1007/s11655-020-3092-9DOI Listing

MAO Ze-dong's View on Traditional Chinese Medicine and Its Modern Significance.

Authors:
En-Chang Li

Chin J Integr Med 2020 Jun 14;26(6):469-472. Epub 2020 Apr 14.

Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, China.

MAO Ze-dong's view on traditional Chinese medicine (TCM) can be divided into the scientific view on TCM, the development view on TCM and the future view on TCM. The core of MAO Ze-dong's view on TCM lies in its scientific nature. The basic content of MAO Ze-dong's development view on TCM includes unity of TCM and Western medicine (WM), advocating the multi-angle development of TCM from the height of Chinese national dignity, independence and self-confidence. Read More

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http://dx.doi.org/10.1007/s11655-020-3470-3DOI Listing

Clinical Efficacy and Transcriptomic Analysis of Congrong Shujing Granules () in Patients with Parkinson's Disease and Syndrome of Shen (Kidney) Essence Deficiency.

Chin J Integr Med 2020 Jun 14;26(6):412-419. Epub 2020 Apr 14.

Geriatrics Department, the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.

Objective: To evaluate the clinical efficacy and safety of Congrong Shujing Granules ( , CSGs) in treating patients with Parkinson's disease (PD) and Chinese medicine (CM) syndrome of Shen (Kidney) essence deficiency, and to investigate the potential mechanism involving efficacy through a transcriptome sequencing approach.

Methods: Eligible PD patients with syndrome of Shen essence defificiency were randomly assigned to a treatment group or a control group by a random number table, and were treated with CSGs combined with Western medicine (WM), or placebo combined with WM, respectively. Both courses of treatment lasted for 12 weeks. Read More

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http://dx.doi.org/10.1007/s11655-020-3080-0DOI Listing
June 2020
1.401 Impact Factor

Effect of Thick-Needle Therapy in Patients with Bell's Palsy at Recovery Stage: A Multi-center Randomized Controlled Trial.

Chin J Integr Med 2020 Jun 14;26(6):455-461. Epub 2020 Apr 14.

Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.

Objective: To compare the clinical effects of thick-needle therapy (TNT) and acupuncture therapy (AT) on patients with Bell's palsy (BP) at the recovery stage.

Methods: A total of 146 eligible participants from 3 hospitals in China were randomized into the TNT group (73 cases) and the AT group (73 cases) using a central randomization. Both groups received Western medicine thrice a day for 4 weeks. Read More

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http://dx.doi.org/10.1007/s11655-020-3081-zDOI Listing

Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome.

Chin J Integr Med 2020 Apr 4. Epub 2020 Apr 4.

Graduate Institute of Integrated Medicine, College of Medicine, Research Center for Chinese Medicine and Acupuncture, Chinese Medicine Research Center, China Medical University, Taichung, Taiwan, China.

Objective: To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome (IC/PBS).

Methods: The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial cells (HUCs) were assessed in vitro. In the animal study, 48 virgin female rats were randomized into 4 groups (12 in each group): (1) control group (saline-injected control); (2) cyclophosphamide (CYP) group (intraperitoneal injected 150 mg/kg CYP); (3) CYP + pentosan polysulfate sodium group (orally received 50 mg/kg pentosan polysulfate sodium); and (4) CYP + frankincense and myrrha group [orally received frankincense (200 mg/kg) and myrrha (200 mg/kg)]. Read More

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http://dx.doi.org/10.1007/s11655-020-3216-2DOI Listing
April 2020
1.401 Impact Factor

Acupuncture for Chronic Fatigue Syndrome: An Overview of Systematic Reviews.

Chin J Integr Med 2020 Apr 1. Epub 2020 Apr 1.

School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Objective: To evaluate the quality of the existing studies and summarize evidence of important outcomes of meta-analyses/systematic reviews (MAs/SRs) of CFS.

Methods: Potentially eligible studies were searched in the following electronic databases from inception to 1 September, 2019: Chinese Biomedical Literature Database (CBM), China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), WanFang Database (WF), Web of Science, Embase, PubMed and Cochrane Library. Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence. Read More

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http://dx.doi.org/10.1007/s11655-020-3195-3DOI Listing

Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats.

Chin J Integr Med 2020 Apr 4. Epub 2020 Apr 4.

Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Objective: To investigate the mechanism of Tojapride, a Chinese herbal formula extract, on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis (RE).

Methods: Ten out of 85 SD rats were randomly selected as the sham group (n10), and 75 rats were developed a reflux esophagitis model (RE) by the esophageal and duodenal side-to-side anastomosis. Fifty successful modeling rats were divided into different medicated groups through a random number table including the model, low-, medium-, and high-dose of Tojapride as well as omeprazole groups (n10). Read More

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http://dx.doi.org/10.1007/s11655-019-3027-5DOI Listing

Protective Effect of Naoxintong Capsule () Combined with Guhong Injection () on Rat Brain Microvascular Endothelial Cells during Cerebral Ischemia-Reperfusion Injury.

Chin J Integr Med 2020 Apr 4. Epub 2020 Apr 4.

College of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Objective: To investigate the synergistic effect of Naoxintong Capsule (NXTC, ) and Guhong Injection (GHI, ) on cerebral ischemia-reperfusion (I/R) injury.

Methods: Forty-eight Sprague-Dawley rats were divided into 6 groups: control group, oxygen and glucose deprivation (OGD) group, nimodipine group (9.375 mg/kg), NXTC group (0. Read More

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http://dx.doi.org/10.1007/s11655-020-3215-3DOI Listing

Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder () in Patients with Chronic Nonbacterial Prostatitis: A Randomized, Double-blind, Placebo-controlled Clinical Trial.

Chin J Integr Med 2020 Apr 1. Epub 2020 Apr 1.

School of Acupuncture-Moxbustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective: To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder (, MDGP) in patients with chronic nonbacterial prostatitis (CNP).

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted among 72 patients with CNP. Participants were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio, and received either MDGP external umbilicus treatment (MDGP group, 36 cases) or placebo control groupl (36 cases) at acupoints Shenque (CV 8), twice a week for 4 weeks. Read More

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http://dx.doi.org/10.1007/s11655-020-3258-5DOI Listing

Effect of Modified Xijiao Dihuang Decoction () on Intestinal Flora and Th17/Treg in Rats with Radiation Enteritis.

Chin J Integr Med 2020 Apr 1. Epub 2020 Apr 1.

Medical School of Chinese People's Liberation Army, The General Hospital of People's Liberation Army, Beijing, 100853, China.

Objective: To observe the effect of Modified Xijiao Dihuang Decoction (, MXDD) on rats with radiation enteritis, and explore its action mechanism.

Methods: Thirty female Sprague Dawley rats were divided into the control, model, dexamethasone (DXM), golden bifid (GB) and MXDD groups using random number table, 6 rats in each group. Except the control group, the other rats were developed into radiation enteritis model by exposing to a single Co-γ ray at a dose of 11 Gy. Read More

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http://dx.doi.org/10.1007/s11655-020-3261-xDOI Listing

Heat-Clearing Chinese Medicines in Lipopolysaccharide-Induced Inflammation.

Chin J Integr Med 2020 Apr 1. Epub 2020 Apr 1.

Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.

Lipopolysaccharide (LPS)-induced inflammation causes massive threatening diseases, such as sepsis, acute lung injury and multiple organ dysfunction syndrome. Efficient treatment to prevent inflammation is crucial in LPS-induced inflammatory diseases. Heat-clearing Chinese medicines (CMs) have been used to ameliorate LPS-induced inflammation in China for centuries. Read More

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http://dx.doi.org/10.1007/s11655-020-3256-7DOI Listing

Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats.

Chin J Integr Med 2020 Jun 1;26(6):434-441. Epub 2020 Apr 1.

Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, 830000, China.

Objective: To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia (PT) on treating aged insomnia rats.

Methods: Sixty Sprague-Dawley male rats were divided into 6 groups by a random number table, including control group, model group, diazepam group (0.92 mg/kg), as well as PT low-, medium- and high-dose groups (0. Read More

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http://dx.doi.org/10.1007/s11655-020-3087-6DOI Listing