117 results match your criteria Chinese journal of digestive diseases[Journal]


Retraction.

Authors:
Shu Dong Xiao

Chin J Dig Dis 2006 ;7(4):246

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http://dx.doi.org/10.1111/j.1443-9573.2006.00276.xDOI Listing
January 2007
8 Reads

Abnormal expression of Smurf2 during the process of rat liver fibrosis.

Chin J Dig Dis 2006 ;7(4):237-45

Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Objective: Liver fibrosis is a prelude of liver cirrhosis. Currently the molecular mechanism of liver fibrosis is not clear. The purpose of this study is to screen the abnormally expressed genes of liver fibrosis and to illustrate the changes of Smurf2 expression in the process of liver fibrosis. Read More

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http://doi.wiley.com/10.1111/j.1443-9573.2006.00275.x
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http://dx.doi.org/10.1111/j.1443-9573.2006.00275.xDOI Listing
January 2007
6 Reads

RNA interference inhibits hepatitis B virus gene expression and replication in HepG2-N10 cells.

Chin J Dig Dis 2006 ;7(4):230-6

Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian Province, China.

Objective: RNA interference (RNAi) refers to the phenomenon of sequence-specific degradation of homologous mRNA induced by double-stranded RNA. It has been successfully utilized to down-regulate endogenous gene expression or suppress the replication of various pathogens in mammalian cells. In this study, the effect of vector-based small interfering RNA (siRNA) promoted by pSilencer2. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00268.xDOI Listing
January 2007
13 Reads

Expression and significance of nerve growth factor receptor p75 in rats' cathartic colonic wall.

Chin J Dig Dis 2006 ;7(4):225-9

Department of Gastroenterology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China.

Objective: To investigate the expression of nerve growth factor receptor p75 in a normal and cathartic colon and its significance in the formation of the cathartic colon in rats.

Methods: Sixty Sprague-Dawley rats were equally divided into normal control group, rhubarb group and phenolphthalein group. A model of the cathartic colon was constructed by gastric infusion with rhubarb or phenolphthalein in rats. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00274.xDOI Listing
January 2007
2 Reads

Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells.

Chin J Dig Dis 2006 ;7(4):219-24

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Background: Non-steroidal anti-inflammatory drugs such as indomethacin can inhibit the growth of tumors through both the cyclooxygenase-2 (COX-2) dependant and COX-2 independent pathways, but the exact mechanism has not yet been shown. In our previous study, COX-2 independent proteins (Bfl-1, WISP-1 and proliferating cell nuclear antigens [PCNA]) in indomethacin-treated colorectal cancer cells with the use of proteomics technology had been identified.

Objectives: To study and confirm the effect of indomethacin on the expression of Bfl-1, WISP-1 and PCNA in human colon cancer line HCT116 cells and the COX-2 independent tumor inhibiting pathway. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00272.xDOI Listing
January 2007
4 Reads

Alternation of substance P-containing neural pathways in a rat model of irritable bowel syndrome with rectal distension.

Chin J Dig Dis 2006 ;7(4):211-8

Department of Gastroenterology, Chinese People's Liberation Army General Hospital, Beijing, China.

Objective: Irritable bowel syndrome (IBS) is a common disorder in clinical practice, but the pathophysiology of IBS has not been completely elucidated yet. Experiments have revealed that the concentrations of some kinds of brain-gut peptides, such as substance P, were abnormal in the plasma and/or the intestinal mucosa. In order to explore further the possible role of substance P containing nerve fibers in the enteric nervous system and central nervous system, the expression of c-fos, a well-established marker of activated neural pathway, was induced to show substance P containing a neural pathway in the rat model of constipation-predominant IBS by rectal distention. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00273.xDOI Listing
January 2007
14 Reads

Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity.

Chin J Dig Dis 2006 ;7(4):206-10

Tsuchiya Medical Corporation Hospital, University of Milan, Italy.

Objective: The aim of the present study was to test a prebiotic-phytotherapic compound in an experimental model of oral allergenicity.

Methods: Antigen-specific immunoglobulin E (IgE) elevated mice were prepared by injecting them intraperitoneally with 10 microg of ovalbumin. Subsequently, the mice were exposed to ovalbumin solution intranasally and blood samples were obtained on weekly intervals for 4 weeks to measure serum-ovalbumin-specific IgE and total immunoglobulin G. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00267.xDOI Listing
January 2007
16 Reads

Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer.

Chin J Dig Dis 2006 ;7(4):197-205

Hereditary non-polyposis colorectal cancer (HNPCC) group, Beijing Army General Hospital, Beijing, China.

Objective: Hereditary non-polyposis colorectal cancer (HNPCC) syndrome is the most common cause of hereditary colorectal cancer with an early age of onset. Microsatellite instability (MSI) and germline mutation in one of the DNA mismatch repair (MMR) genes are found in the majority of HNPCC families and provide an opportunity for genetic diagnosis and prophylactic screening. The MMR gene mutation spectrum may vary across different populations and be influenced by founder mutations that prevail in specific ethnic groups. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00269.xDOI Listing
January 2007
140 Reads

Accuracy of endoscopic ultrasound staging of gastric cancer in routine clinical practice in Singapore.

Chin J Dig Dis 2006 ;7(4):191-6

Division of Gastroenterology, Changi General Hospital, Singapore.

Objective: Endoscopic ultrasound has emerged as the leading modality to assess the T and N stage in gastric cancer. This study aimed to assess the accuracy of TN staging by endoscopic ultrasound in routine clinical practice in Singapore.

Methods: Over a period of 7 years, 77 patients (male: 70%; median age 62. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00270.xDOI Listing
January 2007
13 Reads

Non-erosive reflux disease, functional heartburn and gastroesophageal reflux disease; insights into pathophysiology and clinical presentation.

Chin J Dig Dis 2006 ;7(4):186-90

National University of Ireland, Cork, Ireland.

Non-erosive reflux disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD) and may, indeed, represent the most common manifestation of reflux disease. Recent information indicates NERD can be further subclassified based on the results of pH studies and suggests that functional heartburn needs to be differentiated as that subgroup of patients in which there appears to be no relationship between symptoms, however 'typical' of GERD, and acid exposure. Other aspects of NERD need to be appreciated, including overlap with functional dyspepsia and the potential variations in response to such therapeutic interventions as acid-suppressive therapy and fundoplication. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00266.xDOI Listing
January 2007
10 Reads

Rome III: the new criteria.

Chin J Dig Dis 2006 ;7(4):181-5

UNC Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC 27599, USA.

The new Rome III criteria reflects upon a more than 15 year process to legitimize, classify and bring scientific credibility to the functional GI disorders. This has occurred through a series of activities and documents including the recently published Rome III book and a journal issue in Gastroenterology published in April, 2006. The work involved has involved committees of 87 international investigators from 17 countries, 2 of whom are from China. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00265.xDOI Listing
January 2007
4 Reads

Histopathological study of vascular changes after intra-arterial and intravenous injection of N-butyl-2-cyanoacrylate.

Chin J Dig Dis 2006 ;7(3):175-9

Department of Gastroenterology, General Hospital of PLA, Beijing, China.

Objective: To assess the histopathological vascular changes after injection of N-butyl-2-cyanoacrylate into the vessels of adult rabbits.

Methods: The animals used were 42 pure-blood New Zealand white rabbits weighing 2-3 kg. 0. Read More

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http://doi.wiley.com/10.1111/j.1443-9573.2006.00264.x
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http://dx.doi.org/10.1111/j.1443-9573.2006.00264.xDOI Listing
November 2006
2 Reads

Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.

Chin J Dig Dis 2006 ;7(3):170-4

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Objective: To evaluate the diagnostic value for pancreatic cancer of four serum tumor markers, carbohydrate antigen (CA) 199, CA242, CA50 and carcino-embryonic antigen (CEA), and fecal k-ras and p53 gene mutations.

Methods: From February 2002 to March 2004, 136 patients were consecutively diagnosed with pancreatic cancer in the three participating medical centers. The diagnosis was confirmed by pathology in 53 patients, of whom five were excluded because they did not have measurement of serum tumor marker. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00263.xDOI Listing
November 2006
48 Reads

Alteration of the pancreatic endocrine component in the early stage of acute necrotic pancreatitis in rats.

Chin J Dig Dis 2006 ;7(3):164-9

Department of Pathophysiology, Medical School of Tongji University, Shanghai, China.

Objective: To investigate alterations of the pancreatic endocrine component in the early stage of acute necrotic pancreatitis (ANP) in rats.

Methods: Thirty-six Sprague-Dawley rats were randomly allocated to two groups: ANP group (n = 18) and sham-operated (control) group (n = 18). ANP was induced by retrograde injection of 4% sodium deoxycholate (40 mg/kg, 0. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00262.xDOI Listing
November 2006
4 Reads

Differentiation potential of bone marrow stromal cells to enteric neurons in vitro.

Chin J Dig Dis 2006 ;7(3):156-63

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To investigate whether bone marrow stromal cells (BMSC) can be induced to differentiate into enteric neurons and to produce more nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF).

Methods: Bone marrow stromal cells were harvested from male Sprague-Dawley rats and cultured in Dulbecco's modified eagle medium supplemented with 20% fetal bovine serum. The BMSC were passaged six times and characterized by flow cytometry. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00261.xDOI Listing
November 2006
7 Reads

Effects of acute and chronic restraint stress on visceral sensitivity and neuroendocrine hormones in rats.

Chin J Dig Dis 2006 ;7(3):149-55

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objective: To investigate the effects of acute and chronic partial restraint stress (PRS) on visceral sensitivity to colorectal distention and the neuroendocrine response in rats.

Methods: Male Sprague-Dawley rats were used in this study. The abdominal withdrawal reflex score was assessed before stress, immediately after acute or chronic PRS, and 7 days after the first stress. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00260.xDOI Listing
November 2006
44 Reads

Additional bedtime H2-receptor antagonist for the control of nocturnal gastric acid breakthrough: a Cochrane systematic review.

Chin J Dig Dis 2006 ;7(3):141-8

Department of Gastroenterology, The First People's Hospital of Chengdu, China.

Objectives: To assess the effectiveness and safety of additional bedtime H(2)-receptor antagonists (H(2)RAs) in suppressing nocturnal gastric acid breakthrough (NAB) via a systematic review.

Methods: Eligible trials were identified by searching the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 2, 2004), MEDLINE (January 1966-June 2004), EMBASE (January 1980-June 2004) and CINAHL (January 1982-June 2004). Additional hand-searching was conducted on the proceedings of correlated conferences, eight important Chinese journals and references of all included trials. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00259.xDOI Listing
November 2006
9 Reads

Chemopreventive effects of rofecoxib and folic acid on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Chin J Dig Dis 2006 ;7(3):134-40

Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical College, Jiangsu Province, China.

Objectives: Epidemiological and experimental studies indicate that non-steroidal anti-inflammatory drugs (NSAIDs) are chemopreventive agents of gastrointestinal cancers, but few studies on gastric cancer have been carried out. A decrease in folic acid supplement and subsequent DNA hypomethylation are related to gastrointestinal cancers, and it has been shown that high-dose folic acid may interfere with gastric carcinogenesis in dogs. The objective of this study was to investigate the effects of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and folic acid on the chemoprevention of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Wistar rats, and to evaluate the cell proliferation of gastric mucosa in different experimental groups. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00258.xDOI Listing
November 2006
16 Reads

NSAID-induced gastrointestinal damage: current clinical management and recommendations for prevention.

Chin J Dig Dis 2006 ;7(3):127-33

Service of Gastroenterology, University Hospital of Zaragoza, Spain.

Gastrointestinal toxicity is a common adverse effect of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and patients at risk should receive prevention therapies. Selective cyclooxygenase-2 (COX-2) inhibitors (coxibs) are safer to the gastrointestinal tract than traditional NSAIDs. Current prevention strategies in patients who need NSAIDs should also take into account the presence of cardiovascular risk factors, as coxibs and probably most traditional NSAIDs increase the incidence of serious cardiovascular events. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00257.xDOI Listing
November 2006
1 Read

Influence of glutamine on pancreatic blood flow and apoptosis of pancreatic acinar in rats with severe acute pancreatitis.

Chin J Dig Dis 2006 ;7(2):121-6

Pancreatic Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: To investigate the role of glutamine on splanchnic blood flow, apoptosis of pancreatic acinar and the underlying mechanism in rats with severe acute pancreatitis.

Methods: Forty-eight rats were randomized into two groups: the glutamine group (n = 24) and the severe acute pancreatitis group (n = 24). Jejunotomy was performed in all rats: the glutamine group also received glutamine, and the severe acute pancreatitis group received normal saline. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00250.xDOI Listing
December 2006
11 Reads

Evaluating the role of serum elastase 1 in the diagnosis of pancreatic cancer.

Chin J Dig Dis 2006 ;7(2):117-20

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Objective: To determine the normal value of serum elastase 1 in Chinese adults and evaluate its diagnostic value for pancreatic cancer.

Methods: Serum elastase 1 and CA19-9 were measured in 132 samples, including 39 patients with pancreatic cancer, 48 with other gastrointestinal malignancy, 24 with gastrointestinal benign disease and 21 healthy adults as normal control. Multiple statistical methods including receiver operating characteristics curve and discriminant analysis were employed. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00249.xDOI Listing
December 2006
10 Reads

Treatment of surgically induced acute liver failure by transplantation of HNF4-overexpressing embryonic stem cells.

Chin J Dig Dis 2006 ;7(2):109-16

Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, 145 Shandong Zhong Road, Shanghai 200001, China.

Objective: Tissue-specific stem cells from differentiating embryonic stem (ES) cells are both pluripotent and genetically flexible. Recent observations indicate that ES cells can differentiate into hepatocytes. Therefore, cell-based therapy can potentially be a therapeutic alternative to liver transplantation. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00253.xDOI Listing
December 2006
9 Reads

Expression of gamma-aminobutyric acid and glutamic acid decarboxylases in rat descending colon and their relation to epithelial differentiation.

Chin J Dig Dis 2006 ;7(2):103-8

Department of Gastroenterology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing, China.

Objective: To detect the expression of gamma-aminobutyric acid (GABA) and glutamic acid decarboxylases (GADs; including two isoforms GAD65 and GAD67) in the epithelial growth zones of the descending colon in rats, and to investigate their relation to epithelial differentiation and proliferation.

Methods: The expression of GABA and GADs in rat descending colon was investigated by immunofluorescent staining and confocal laser scanning techniques, and goblet cells were further investigated by wheat-germ agglutinin histochemistry. In addition, GAD65 and GAD67 mRNAs were also detected by reverse transcription-polymerase chain reaction. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00247.xDOI Listing
December 2006
10 Reads

Analysis of gene expression profile in colon cancer using the Cancer Genome Anatomy Project and RNA interference.

Chin J Dig Dis 2006 ;7(2):97-102

Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai, China.

Objective: To investigate the changes in the gene expression profile in colon cancer to further identify gene markers that may be useful in the management of this disease.

Methods: Data from serial analysis of gene expression (SAGE) collected by the Cancer Genome Anatomy Project (CGAP) were used to detect the difference in gene expression between normal tissue and colon cancer, and were further confirmed in a sample of 20 patients using RT-PCR. To identify the functions of differential genes in regulating the cell growth of colon cancer, RNA interference (RNAi) was used to block one of these genes in the colon cancer cell line HCT-116. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00254.xDOI Listing
December 2006
9 Reads

Effect of change in an inhibitory neurotransmitter of the myenteric plexus on the pathogenetic mechanism of irritable bowel syndrome subgroups in rat models.

Chin J Dig Dis 2006 ;7(2):89-96

Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Shaanxi Province, China.

Objective: In order to investigate the effect of change in an inhibitory neurotransmitter of the myenteric plexus on irritable bowel syndrome (IBS) subgroups, the amounts of nitric oxide (NO) in constipation-predominant (C-IBS) and diarrhea-predominant (D-IBS) IBS models in rats were studied.

Methods: The D-IBS model was created in rats by intracolonic instillation of acetic acid and by restraint stress. The D-IBS control group underwent intracolonic instillation with saline instead. Read More

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http://doi.wiley.com/10.1111/j.1443-9573.2006.00248.x
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http://dx.doi.org/10.1111/j.1443-9573.2006.00248.xDOI Listing
December 2006
7 Reads

Diet and gastric cancer: a case-control study in Shanghai urban districts.

Chin J Dig Dis 2006 ;7(2):83-8

Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.

Objective: The incidence rates of gastric cancer in Shanghai urban districts have been markedly declining over the past three decades. From 1972 to 2001 the age-adjusted incidence rates of gastric cancer decreased from 62.0 to 32. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00252.xDOI Listing
December 2006
6 Reads

Advances in mechanisms of postsurgical gastroparesis syndrome and its diagnosis and treatment.

Chin J Dig Dis 2006 ;7(2):76-82

Department of General Surgery, Sichuan Province People's Hospital, Chengdu, China.

Postsurgical gastroparesis syndrome (PGS) is a complex disorder characterized by post-prandial nausea and vomiting, and gastric atony in the absence of mechanical gastric outlet obstruction, and is often caused by operation at the upper abdomen, especially by gastric or pancreatic resection, and sometimes also by operation at the lower abdomen, such as gynecological or obstetrical procedures. PGS occurs easily with oral intake of food or change in the form of food after operation. These symptoms can be disabling and often fail to be alleviated by drug therapy, and gastric reoperations usually prove unsuccessful. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00255.xDOI Listing
December 2006
9 Reads

Clinical aspects of ulcerative colitis in mainland China.

Authors:
Jia Ju Zheng

Chin J Dig Dis 2006 ;7(2):71-5

Suzhou Municipal Hospital and Suzhou Institute for Digestive Disease and Nutrition, Suzhou, China.

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is reported to be increasing in incidence and prevalence in provinces and cities in mainland China. This article specifically reviews clinical features, extra-intestinal manifestations, complications, diagnosis and differential diagnosis, and medical treatment of UC. Compared to patients in Western countries, more mild to moderate and left-sided colitis cases were observed in a nation-wide study in China. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00251.xDOI Listing
December 2006
2 Reads

Per-oral transgastric abdominal surgery.

Chin J Dig Dis 2006 ;7(2):67-70

Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.

Laparoscopic surgery has several advantages over traditional surgery because it has been shown to be less invasive. The next logical step in the evolution of minimally invasive surgery may be to eliminate all abdominal incisions. The natural orifices provide a port of entry via the gastrointestinal tract to the peritoneal cavity. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00256.xDOI Listing
December 2006
31 Reads

Association of peptic ulcer with increased expression of Lewis antigens, but not vacuolating cytotoxin activity or babA2 gene status, in Helicobacter pylori strains from China.

Chin J Dig Dis 2006 ;7(1):61-5

Division of Gastroenterology, 2nd Affiliated Hospital of Zhengzhou University, China.

Objective: Controversies exist regarding the virulence factors, such as vacA, babA2 and Lewis blood group antigens, of Western and Asian strains of Helicobacter pylori. The aim of the present study was to determine the significance of these potential virulence factors in the Chinese population.

Methods: Seventy-two strains of H. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00246.xDOI Listing
July 2006
2 Reads

Prevalence and risk factors of Helicobacter pylori infection in healthy schoolchildren.

Chin J Dig Dis 2006 ;7(1):55-60

Department of Surgery, Division of Gastrointestinal Surgery, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan.

Objective: Data regarding the prevalence of Helicobacter pylori infection and its potential risk factors among schoolchildren from the Middle East is scarce.

Methods: An enzyme-linked immunosorbent assay was used to investigate H. pylori status in four groups of children: The first and second groups, 50 children each (25 boys, 25 girls) included children from high socioeconomic class (group 1 = 6 years old; group 2 = 9 years old). Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00245.xDOI Listing
July 2006
35 Reads

Meta-analysis of inoperable pancreatic cancer: gemcitabine combined with cisplatin versus gemcitabine alone.

Chin J Dig Dis 2006 ;7(1):49-54

Department of Oncology, The Second Affiliated Hospital, Sun Yat-Sen University and Zhongshan People's Hospital, Zhongshan, Guangdong Province, China.

Objectives: To compare the therapeutic effects of gemcitabine (GEM) monotherapy with GEM-cisplatin (DDP) combination chemotherapy in patients with advanced stage pancreatic cancer (APCa) through meta-analysis.

Methods: MEDLINE and EMBASE searches were supplemented by information from trial registers of randomized controlled trials (RCTs) for GEM-DDP combination chemotherapy and GEM alone in APCa. A quantitative meta-analysis using updated information based on inclusion criteria from all available RCTs was carried out by two reviewers. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00244.xDOI Listing
July 2006
8 Reads

Prospective randomized clinical trial of two drug delivery pathway in the treatment of inoperable advanced pancreatic carcinoma.

Chin J Dig Dis 2006 ;7(1):45-8

Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Objectives: Evaluate the effect of an implanted percutaneous left subclavian artery port-catheter drug delivery system for regional chemotherapy of inoperable pancreatic carcinoma.

Methods: One hundred and forty patients with inoperable pancreatic carcinoma were enrolled and randomized into two groups to receive the FAM regimen on a 6-day cycle at 1-month intervals: 70 patients in the regional interventional chemotherapy group in which treatment was infused directly into the common hepatic artery, and 70 patients who received the same chemotherapy regimen via the peripheral vein.

Result: In the interventional chemotherapy group, there were 5 cases of complete remission (CR) and 49 cases of partial remission (PR), giving a response rate (CR+PR) of 77. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00243.xDOI Listing
July 2006
22 Reads

Serous cystic neoplasms of the pancreas: a clinicopathologic and immunohistochemical analysis.

Chin J Dig Dis 2006 ;7(1):39-44

Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: To clarify whether the various subtypes of serous cystic neoplasms (SCNs) of the pancreas can be distinguished from each other by marker profiles.

Methods: The immunoprofiles of 13 SCNs were defined by using antibodies against cytoskeletal, neuroendocrine, hormone receptor, and mucin markers. In addition, we examined the expression of calrentinin and alpha-inhibin. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00242.xDOI Listing
July 2006
13 Reads

Preventive strategy for Candida gut translocation during ischemia-reperfusion injury supervening on protein-calorie malnutrition.

Chin J Dig Dis 2006 ;7(1):33-8

WHO-Collaborative Center for Traditional Medicine, S Giuseppe Hospital, University of Milan, Milan, Italy.

Objective: The aim of the present study was to test the hypothesis that protein-calorie malnutrition aggravates the gut translocation of Candida albicans triggered by mesenteric ischemia-reperfusion (IR) injury in an experimental model while testing a natural product containing the antifungal anethole/polygodial mixture (Kolorex).

Methods: MFI strain white mice (n = 90) were randomly allocated to a 4-week dietary regimen: (1) standard pellet diet containing 25% casein; (2) low-protein (2.5%) casein diet; (3) as group 2 plus oral supplementation with 20 microL of a 5% solution of Kolorex during the last 4 days. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00241.xDOI Listing
July 2006
1 Read

Appropriateness of colonoscopy using the ASGE guidelines: experience in a large Asian hospital.

Authors:
T H Chan K L Goh

Chin J Dig Dis 2006 ;7(1):24-32

Division of Gastroenterology and Hepatology, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The is currently a heavy burden on endoscopy services worldwide and although guidelines for the appropriate use of esophagogastroduodenoscopy (EGD) have been well studied, there are few such studies with respect to colonoscopy and none for the Asia-Pacific region. This study aimed, firstly, to determine the 'appropriateness of colonoscopy' for procedures performed in the endoscopy unit of a large Asian hospital using the American Society of Gastrointestinal Endoscopy (ASGE) 2000 guidelines, and secondly, to determine predictive factors including 'appropriateness of colonoscopy' for positive findings and colorectal cancer (CRC).

Methods: A prospective cross-sectional study was carried out on consecutive colonoscopies performed in the University of Malaya Medical Center. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00240.xDOI Listing
July 2006
4 Reads

Gastric distention enhances FOS and calcitonin gene-related peptide expression in the spinal cord and brain of rats.

Chin J Dig Dis 2006 ;7(1):19-23

Department of Gastroenterology, Shanghai Armed Police Hospital, Shanghai, China.

Objective: The purpose of this study was to determine the pathway and mode of transmission of visceral stimuli by investigating the distribution of the FOS and calcitonin gene-related peptide (CGRP) proteins in the central nervous system.

Methods: Twenty-four Sprague-Dawley rats were divided into three groups: study group (n = 12), sham control group (n = 6), and normal control group (n = 6). A balloon was implanted into the stomach of the rats in the study and sham control groups. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00239.xDOI Listing
July 2006
6 Reads

Combined histology and molecular biology for diagnosis of early stage gastric MALT lymphoma.

Chin J Dig Dis 2006 ;7(1):12-8

Department of Gastroenterology, West China Hospital, Sichuan Universty, Chengdu, Sichuan Province, China.

Objective: To establish a sequential diagnostic procedure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma and provide evidence for selected optimal cases to be treated in the early stage.

Methods: Thirty-one cases of gastric lymphoid hyperplasia (GLH) were selected and multiple investigations including histology, protein level, DNA and chromosome levels, combined with clinical follow-up were performed. Histological grade was according to Isaacson's criteria of GLH; CD20, UCHL-1 (CD45RO), anti-kappa (kappa), anti-lambda (lambda) and Ki-67 were used for immunohistochemical staining; semi-nested polymerase chain reaction (PCR) was used to detect IgH gene rearrangement and reverse-transcription PCR (RT-PCR) was used to detect API2-MALT1 fusion of the chromosome translocation t(11;18)(q21;q21). Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00238.xDOI Listing
July 2006
3 Reads

Pathogenesis of nonalcoholic steatohepatitis (NASH).

Authors:
Xiong Ma Zhiping Li

Chin J Dig Dis 2006 ;7(1):7-11

Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21205, USA.

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver diseases that range from hepatic steatosis at the most clinically benign end of the spectrum, through an intermediate lesion, nonalcoholic steatohepatitis (NASH), to cirrhosis at the opposite extreme. Epidemiology studies have estimated that about 20-30% of adults in the United States and other Western countries have NAFLD, and of these about 10% (2-3% of adults) meet the diagnostic criteria of NASH. Studies of animals and humans with obesity-related fatty liver disease have revealed much about the mechanisms that mediate this common pathology. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00237.xDOI Listing
July 2006
77 Reads

Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.

Authors:
I Hilmi K L Goh

Chin J Dig Dis 2006 ;7(1):1-6

Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Colorectal carcinoma is one of the commonest solid organ tumors in the world and its prevalence appears to be increasing in Asia. Recently, there has been much interest in various chemotherapeutic agents for the management of this condition, in particular nonsteroidal anti-inflammatory drugs (NSAIDs). There is a large amount of data that suggest traditional NSAIDs, as well as the new cyclooxygenase (COX)-2 selective inhibitors such as rofecoxib and celecoxib, have a role in the setting of primary and secondary prevention, and adjuvant therapy of both sporadic colorectal carcinoma and familial adenomatous polyposis. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2006.00236.xDOI Listing
July 2006
1 Read

Hypereosinophilic syndrome presenting with eosinophilic colitis, enteritis and cystitis.

Chin J Dig Dis 2005 ;6(4):206-8

Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1111/j.1443-9573.2005.00231.xDOI Listing
January 2006
27 Reads

Comparison of the efficacy of 1-day high-dose quadruple therapy versus 7-day triple therapy for treatment of Helicobacter pylori infection.

Chin J Dig Dis 2005 ;6(4):202-5

Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Renji Hospital, Shanghai, China.

Background: The proton pump inhibitor (PPI)-based 7-day triple therapy is the regimen with the highest cure rates for eradication of Helicobacter pylori infection and has been recommended as the first-line regimen in the world. It had been reported that a 1-day quadruple therapy could also successfully cure 95% of the H. pylori infected patients. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00233.xDOI Listing
January 2006
26 Reads

Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect.

Chin J Dig Dis 2005 ;6(4):193-7

Hepato-Gastroenterology Department, S. Giuseppe Hospital, Milan, Italy.

Objective: The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion.

Methods: Sprague-Dawley rats were fed for 1 week through an intragastric tube a liquid diet with either: (i) 1 mL t.i. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00230.xDOI Listing
January 2006
8 Reads

Effects of sodium phenylbutyrate on differentiation and induction of the P21WAF1/CIP1 anti-oncogene in human liver carcinoma cell lines.

Chin J Dig Dis 2005 ;6(4):189-92

Department of Gastroenterology, Shandong Provincial Hospital, Jinan, China.

Objectives: To explore the effects of sodium phenylbutyrate on the proliferation, differentiation, cell cycle arrest and induction of the P(21WAF1/CIP1) anti-oncogene in human liver carcinoma cell lines Bel-7402 and HepG2.

Methods: Bel-7402 and HepG2 human liver carcinoma cells were treated with sodium phenylbutyrate at different concentrations. Light microscopy was used to observe morphological changes in the carcinoma cells. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00229.xDOI Listing
January 2006
17 Reads

Epidemiology and genotypes of HEV in Wuhan.

Chin J Dig Dis 2005 ;6(4):182-8

Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Understanding the genotype and clinical features of the hepatitis E virus (HEV) are important for understanding its characteristics, for evaluating region-specific diagnostic assays, and producing vaccines.

Objectives: To investigate the epidemiology and the genotypes of HEV among outpatients and inpatients in the Department of Infectious Diseases of Tongji Hospital in Wuhan, China.

Methods: Clinical data were elicited from the hospital records of patients who were clinically diagnosed with acute hepatitis between January 2000 and August 2004 (4920 patients). Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00228.xDOI Listing
January 2006
7 Reads

Crohn's disease in mainland China: a systematic analysis of 50 years of research.

Chin J Dig Dis 2005 ;6(4):175-81

Suzhou Institute for Digestive Disease and Nutrition, Suzhou University, Suzhou, China.

Background: Crohn's disease appears to be increasing in frequency in many areas of the world. However, little information with regard to disease incidence, prevalence and temporal trends has been published in China.

Objective: The aim of this review is to better understand the occurrence of Crohn's disease in mainland China, and to give an overview of the current status of the disease. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00227.xDOI Listing
January 2006
6 Reads

Correlation between a gene polymorphism of tumor necrosis factor and inflammatory bowel disease.

Chin J Dig Dis 2005 ;6(4):170-4

Department of Gastroenterology, Xi'an Municipal Central Hospital, Xi'an, China.

Objectives: To analyze polymorphism of the tumor necrosis factor (TNF) gene in inflammatory bowel disease (IBD) patients from the Han Chinese ethnic group, and to investigate the role of polymorphism in the pathogenesis of IBD.

Methods: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were used to analyze gene polymorphisms in the TNF-alpha and TNF-beta genes in 131 patients with IBD.

Results: The genotype frequency and allelic frequency of TNF-alpha-308 in patients with ulcerative colitis (UC) were 15. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00226.xDOI Listing
January 2006
51 Reads

Laparoscopic versus open appendectomy in West Bengal, India.

Authors:
De Utpal

Chin J Dig Dis 2005 ;6(4):165-9

Department of Surgery, Burdwan Medical College, Burdwan, West Bengal, India.

Objective: Laparoscopic appendectomy, although widely practiced, has not gained universal approval. Laparoscopic appendectomy in India is relatively new, and reports regarding its use are few. The aim of this study was to compare laparoscopic with open appendectomy and ascertain its therapeutic benefit, if any, in the overall management of acute appendicitis. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00225.xDOI Listing
January 2006
11 Reads

Preoperative diagnosis of gastric cancer using 2-D magnetic resonance imaging with 3-D reconstruction techniques.

Chin J Dig Dis 2005 ;6(4):159-64

Department of Radiology, Renji Hospital, Shanghai Second Medical University, Shanghai, China.

Objective: To investigate the clinical value of 2-D magnetic resonance imaging (MRI) with 3-D reconstruction techniques for the preoperative diagnosis and TNM-staging of gastric cancer.

Methods: Using a Philips Gyroscan NT 1.0T superconductive unit, MRI using the water-filling method was performed in 15 patients with suspected gastric cancers. Read More

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http://dx.doi.org/10.1111/j.1443-9573.2005.00224.xDOI Listing
January 2006
13 Reads