768 results match your criteria Chinese journal of cancer research = Chung-kuo yen cheng yen chiu[Journal]


Evaluation and reflection on claudin 18.2 targeting therapy in advanced gastric cancer.

Chin J Cancer Res 2020 Apr;32(2):263-270

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Claudin 18.2 (CLDN18.2) is a tight-junction protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219097PMC

Oncometabolic surgery: Emergence and legitimacy for investigation.

Chin J Cancer Res 2020 Apr;32(2):252-262

Division of Foregut Surgery, Korea University College of Medicine, Seoul 136-701, Republic of Korea.

Studies on morbid obesity have shown remarkable improvement of diabetes in patients who have undergone bariatric operations. It was subsequently shown that these operations induce diabetes remission independent of the resultant weight loss; as a result, surgeons began to investigate whether operations for gastric cancer (GC) could have the same beneficial effect on diabetes as bariatric operations. It was then shown in multiple reports that followed that certain operations for GC were able to improve or even cure type 2 diabetes mellitus (T2DM) in GC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219104PMC

Data mining-based model and risk prediction of colorectal cancer by using secondary health data: A systematic review.

Chin J Cancer Res 2020 Apr;32(2):242-251

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: Prevention and early detection of colorectal cancer (CRC) can increase the chances of successful treatment and reduce burden. Various data mining technologies have been utilized to strengthen the early detection of CRC in primary care. Evidence synthesis on the model's effectiveness is scant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219096PMC
April 2020
0.932 Impact Factor

Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer.

Chin J Cancer Res 2020 Apr;32(2):228-241

Division of Colon and Rectal Surgery, Department of Surgery.

Objective: The aim of this study is to develop a nomogram for prediction of pathologic complete remission (pCR) after preoperative chemoradiotherapy (CRT) for rectal cancer.

Methods: mRNA expression levels of seven molecular markers [p53, p21, Ki-67, vascular endothelial growth factor (VEGF), CD133, CD24, CD44] were measured by reverse transcriptase polymerase chain reaction (RT-PCR) in 120 rectal cancers. Endoscopic findings of clinical complete remission (cCR) and biologic variables were used to construct nomogram in the training group (n=80), which was validated in the validation group (n=40). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219094PMC

Phase 1/2 study of concurrent chemoradiotherapy with weekly irinotecan hydrochloride for advanced/recurrence uterine cancer: A multi-institutional study of Kansai Clinical Oncology Group.

Chin J Cancer Res 2020 Apr;32(2):218-227

Department of Obstetrics and Gynecology, National Hospital Organization Kobe Medical Center, Kobe 6540155, Japan.

Objective: Concurrent chemoradiotherapy using cisplatin was thought to be standard treatment for squamous cell carcinoma of cervix, but it had not been effective for adenocarcinoma. Concurrent chemoradiotherapy using irinotecan hydrochloride (CPT-11) had been effective for colorectal cancer, thus, we chose CPT-11 as a candidate for gynecologic adenocarcinoma. To evaluate the maximum tolerated dose (MTD) of weekly CPT-11 with external pelvic radiotherapy, a phase 1/2 study was conducted according to modified Fibonacci method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219098PMC

p16/Ki-67 dual-stained cytology used for triage in cervical cancer opportunistic screening.

Chin J Cancer Res 2020 Apr;32(2):208-217

Department of Gynecology and Obstetrics, The Third Hospital of Peking University, Beijing 100191, China.

Objective: To evaluate the efficiency of p16/Ki-67 dual stain used as a triage in cervical cancer screening.

Methods: In this study, we did 468 p16/Ki-67 dual stain in human papillomavirus (HPV) 16/18-positive or 12 other high-risk HPV (OHR-HPV) positive Thinprep cytologic test (TCT) atypical squamous cells of undetermined significance (ASCUS)/ lower-grade squamous intraepithelial lesion (LSIL) women. We evaluated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the triage test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219095PMC
April 2020
0.932 Impact Factor

Analysis and external validation of a nomogram to predict peritoneal dissemination in gastric cancer.

Chin J Cancer Res 2020 Apr;32(2):197-207

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

Objective: Peritoneal dissemination is difficult to diagnose by conventional imaging technologies. We aimed to construct a nomogram to predict peritoneal dissemination in gastric cancer (GC) patients.

Methods: We retrospectively analyzed 1,112 GC patients in Sun Yat-sen University Cancer Center between 2001 and 2010 as the development set and 474 patients from The Sixth Affiliated Hospital, Sun Yat-sen University between 2010 and 2016 as the validation set. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219103PMC

Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy.

Chin J Cancer Res 2020 Apr;32(2):186-196

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: The proximal margin (PM) distance for distal gastrectomy (DG) of gastric cancer (GC) remains controversial. This study investigated the prognostic value of PM distance for survival outcomes, and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction nomogram.

Methods: Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery, Nanfang Hospital, Southern Medical University were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219099PMC

Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features.

Chin J Cancer Res 2020 Apr;32(2):175-185

Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Objective: To evaluate the human epidermal growth factor receptor 2 (HER2) status in patients with breast cancer using multidetector computed tomography (MDCT)-based handcrafted and deep radiomics features.

Methods: This retrospective study enrolled 339 female patients (primary cohort, n=177; validation cohort, n=162) with pathologically confirmed invasive breast cancer. Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219093PMC

Clinicopathological analysis of early-stage breast cancer patients that meet indications for genetic testing.

Chin J Cancer Res 2020 Apr;32(2):163-174

Breast Disease Center, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate the clinicopathological characteristics and prognostic factors of early-stage breast cancer patients with indications for breast cancer susceptibility genes 1/2 () genetic testing in China.

Methods: Based on the indication criteria for genetic testing specified in the National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology, genetic/familial high-risk assessment: Breast and ovarian (Version 2. 2019), a retrospective analysis was performed on patients with early-stage invasive breast cancer treated at Breast Disease Center, Peking University First Hospital between January 2008 and December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219101PMC

Efficacy of platinum in advanced triple-negative breast cancer with germline mutation determined by next generation sequencing.

Chin J Cancer Res 2020 Apr;32(2):149-162

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China.

Objective: To compare the efficacy of platinum- and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer (TNBC) and analyze the relationship between their efficacy and gene status.

Methods: Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy. A total of 114 patients had / gene tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between their efficacy and / gene status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219102PMC
April 2020
0.932 Impact Factor

The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population.

Chin J Cancer Res 2020 Apr;32(2):140-148

Department of Ultrasound, Peking University Cancer Hospital and Institute, Beijing 100142, China.

Objective: To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology (TBSRTC) at Peking University Cancer Hospital, the incidence of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), and the impact of reclassification on cytopathological outcomes.

Methods: We performed a retrospective study of thyroid fine-needle aspiration (FNA) cases between April 2014 and March 2019. The FNA results were classified according to TBSRTC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219100PMC

Cancer burden and trends in China: A review and comparison with Japan and South Korea.

Chin J Cancer Res 2020 Apr;32(2):129-139

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

Objective: To summarize the cancer burden and trends in China, compare the differences among China, Japan, and South Korea and discuss possible causes of the disparities.

Methods: Incidence and mortality data were extracted from the online cancer database including the GLOBOCAN 2018 and the Global Burden of Disease Study 2017. Trend analysis was conducted using the join-point analysis, and annual percent changes were calculated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219092PMC

Advances and challenges in immunotherapy of small cell lung cancer.

Chin J Cancer Res 2020 Feb;32(1):115-128

Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.

Small cell lung cancer (SCLC) is a highly lethal disease, characterized by early metastasis and rapid growth, and no effective treatment after relapse. Etoposide-platinum (EP) combination has been the backbone therapy of SCLC over the past 30 years. It is extremely urgent and important to seek new therapies for SCLC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072020PMC
February 2020

A nomogram to preoperatively predict 1-year disease-specific survival in resected pancreatic cancer following neoadjuvant chemoradiation therapy.

Chin J Cancer Res 2020 Feb;32(1):105-114

Division of HBP Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul 03722, Korea.

Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical parameters. Extended pancreatectomy is necessary to achieve complete tumor removal in borderline resectable and locally advanced pancreatic cancer. However, it increases postoperative morbidity and mortality rates, and should be balanced with potential benefit of long-term survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072019PMC
February 2020

Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma.

Chin J Cancer Res 2020 Feb;32(1):96-104

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: To explore the correlation between the spectral computed tomography (CT) imaging parameters and the Ki-67 labeling index in lung adenocarcinoma.

Methods: Spectral CT imaging parameters [iodine concentrations of lesions (ICLs) in the arterial phase (ICLa) and venous phase (ICLv), normalized IC in the aorta (NICa/NICv), slope of the spectral HU curve (λHUa/λHUv) and monochromatic CT number enhancement on 40 keV and 70 keV images (CT40keVa/v, CT70keVa/v)] in 34 lung adenocarcinomas were analyzed, and common molecular markers, including the Ki-67 labeling index, were detected with immunohistochemistry. Different Ki-67 labeling indexes were measured and grouped into four grades according to the number of positive-stained cells (grade 0, ≤1%; 1%30%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072011PMC
February 2020

PGC-MG7 combination could be used as a follow-up panel for monitoring dynamical progression of gastric precancerous diseases.

Chin J Cancer Res 2020 Feb;32(1):89-95

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China.

Objective: The aim of this study was to investigate the value of the combined expression of the gastric mucosal differentiation protein pepsinogen C (PGC) and gastric cancer (GC)-associated antigen MG7 for the diagnosis of GC and prediction of the development from precancerous conditions to GC.

Methods: The gastric mucosal biopsies of 285 subjects enrolled from a region with a high incidence of GC were obtained and histopathologically examined. Subjects testing negative for GC (n=208) were followed up from 1998 to 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072012PMC
February 2020

Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGFβ2/NF-κB/Kindlin-2 axis.

Chin J Cancer Res 2020 Feb;32(1):72-88

Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.

Objective: Recent studies have shown that tumor-associated macrophages (TAMs) play an important role in cancer invasion and metastasis. Our previous studies have reported that TAMs promote the invasion and metastasis of gastric cancer (GC) cells through the Kindlin-2 pathway. However, the mechanism needs to be clarified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072013PMC
February 2020
0.932 Impact Factor

A CT-based radiomics nomogram for prediction of human epidermal growth factor receptor 2 status in patients with gastric cancer.

Chin J Cancer Res 2020 Feb;32(1):62-71

Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Objective: To develop and validate a computed tomography (CT)-based radiomics nomogram for predicting human epidermal growth factor receptor 2 (HER2) status in patients with gastric cancer.

Methods: This retrospective study included 134 patients with gastric cancer (HER2-negative: n=87; HER2-positive: n=47) from April 2013 to March 2018, who were then randomly divided into training (n=94) and validation (n=40) cohorts. Radiomics features were obtained from the CT images showing gastric cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072015PMC
February 2020

Prognostic impact of D2-plus lymphadenectomy and optimal extent of lymphadenectomy in advanced gastric antral carcinoma: Propensity score matching analysis.

Chin J Cancer Res 2020 Feb;32(1):51-61

Department of Gastrointestinal Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer; Key Laboratory of Cancer Prevention and Therapy; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: To investigate the prognostic impact of D2-plus lymphadenectomy including the posterior (No. 8p, No. 12b/p, No. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072021PMC
February 2020

Factors associated with metastasis in superior mesenteric vein lymph node in subtotal gastrectomy for gastric cancer: Retrospective case control study.

Chin J Cancer Res 2020 Feb;32(1):43-50

Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang-si 410-769, Republic of Korea.

Objective: The revised Japanese treatment guideline for gastric cancer recommends dissection of the superior mesenteric vein lymph node (No. 14v LN) if there is metastasis in infrapyloric lymph node (No. 6 LN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072010PMC
February 2020

Effects of neoadjuvant chemotherapy on respiratory function in patients with breast cancer.

Chin J Cancer Res 2020 Feb;32(1):36-42

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: To evaluate changes in chest X-rays, pulmonary function tests (PFTs) and quality of life in female breast cancer patients who had been treated with four cycles of neoadjuvant chemotherapy consisting of a regimen of cyclophosphamide, epirubicin and 5-fluorouracil (CEF regimen), and to determine the correlation between pulmonary function parameters and declined quality of life.

Methods: Twenty-nine eligible female patients diagnosed with breast cancer at the first visit who were 20-60 years old, were classified as the American Society of Anesthesiologists (ASA) I-II and patients whose body mass index (BMI) <30 kg/m were recruited and subjected to chest X-ray examinations, PFTs and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) questionnaire before and after receiving 4 cycles of the CEF regimen.

Results: In this study, chest X-rays showed no abnormal changes after chemotherapy, but significant decreases in carbon monoxide diffusing capacity (DLCO) and percentage of the DLCO predicted value (DLCO%) (P<0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072022PMC
February 2020

An exploration for quantification of overdiagnosis and its effect for breast cancer screening.

Chin J Cancer Res 2020 Feb;32(1):26-35

Department of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Objective: To redefine overdiagnosis and reestimate the proportion of overdiagnosis of breast cancer caused by screening based on the Surveillance, Epidemiology, and End Results (SEER, 1973-2015) Program data.

Methods: The breast cancer diagnosed before 1977 was defined as the no-screening cohort since America had initiated breast cancer screening from 1977. The breast cancer diagnosed in 1999 was defined as the screening cohort due to no increases in both the proportion of early-stage breast cancer until 1999 and the overall survival of early-stage breast cancer diagnosed over the three years since 1999. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072016PMC
February 2020

Updates on larynx cancer epidemiology.

Chin J Cancer Res 2020 Feb;32(1):18-25

Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona 37134, Italy.

Objective: Laryngeal cancer is an important oncologic entity, whose prognosis depends on establishing appropriate preventive and diagnostic measures, especially in populations at higher risk.

Methods: Epidemiologic information including worldwide incidence, prevalence, burden of health loss (disability-adjusted life year; DALYs) and mortality of larynx cancer was obtained from the Global Health Data Exchange (GHDx) database.

Results: The current incidence, prevalence and mortality of laryngeal cancer are estimated at 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072014PMC
February 2020

Incidence and mortality of laryngeal cancer in China, 2015.

Chin J Cancer Res 2020 Feb;32(1):10-17

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100021, China.

Objective: Using data from cancer registries to estimate laryngeal cancer incidence and mortality in China, 2015.

Methods: Data submitted from 501 cancer registries were checked and evaluated according to the criteria of data quality control and 368 registries' data were qualified for the final analysis. Data were stratified by area (urban/rural), sex, age group and combined with national population data to estimate laryngeal cancer incidence and mortality in China, 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072018PMC
February 2020

Incidence and mortality of oral and oropharyngeal cancer in China, 2015.

Chin J Cancer Res 2020 Feb;32(1):1-9

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China.

Objective: To report the incidence and mortality rates of oral and oropharyngeal cancer in Chinese population.

Methods: Data were taken from a population-based cancer registry collected by the National Central Cancer Registry of China (NCCRC) in 2015. The data collected from 501 local cancer registries in China were assessed using NCCRC screening methods and criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072017PMC
February 2020

Prediction of pathological nodal stage of locally advanced rectal cancer by collective features of multiple lymph nodes in magnetic resonance images before and after neoadjuvant chemoradiotherapy.

Chin J Cancer Res 2019 Dec;31(6):984-992

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: To predict pathological nodal stage of locally advanced rectal cancer by a radiomic method that uses collective features of multiple lymph nodes (LNs) in magnetic resonance images before and after neoadjuvant chemoradiotherapy (NCRT).

Methods: A total of 215 patients were included in this study and chronologically divided into the discovery cohort (n=143) and validation cohort (n=72). In total, 2,931 pre-NCRT LNs and 1,520 post-NCRT LNs were delineated from all visible rectal LNs in magnetic resonance images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955159PMC
December 2019

Economic evaluation of cervical cancer screening strategies in urban China.

Chin J Cancer Res 2019 Dec;31(6):974-983

Department of Epidemiology, School of Public Health, Dalian Medical University, Dalian 116044, China.

Objective: This study evaluated the feasibility of different cervical cancer screening strategies in urban China.

Methods: A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period. Screening strategies included liquid-based cytology (LBC) every three years, human papillomavirus (HPV) DNA testing every three and five years, respectively, and a combination of HPV DNA testing and LBC (HPV+LBC) every three and five years, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955165PMC
December 2019

An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma.

Chin J Cancer Res 2019 Dec;31(6):965-973

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

Objective: To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma (EC).

Methods: A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016. Clinical characteristics and preoperative serum calcium, albumin, carbohydrate antigen (CA)125, CA19-9, carcinoembryonic antigen (CEA) were extracted from patient records and evaluated according to postoperative peritoneal cytology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955164PMC
December 2019

Relationship between inter--trypsin inhibitor heavy chain 4 and ovarian cancer.

Chin J Cancer Res 2019 Dec;31(6):955-964

Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.

Objective: The inter-α-trypsin inhibitor heavy chain 4 (ITIH4) protein is involved in the development of tumors. However, the relationship between ITIH4 and ovarian cancer (OC) has not been extensively examined. This study aimed to explore the effect of ITIH4 on OC and to identify its underlying mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955170PMC
December 2019
0.932 Impact Factor

Diagnostic value of negative enrichment and immune fluorescence hybridization for intraperitoneal free cancer cells of gastric cancer.

Chin J Cancer Res 2019 Dec;31(6):945-954

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: To explore the intraperitoneal free cancer cell (IFCC) detection value of negative enrichment and immune fluorescence hybridization (NEimFISH) on chromosomes (CEN) 8/17.

Methods: To verify the reliability of NEimFISH, 29 gastric cancer tumors, their adjacent tissues and greater omental tissues were tested. Our study then included 105 gastric cancer patients for IFCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955163PMC
December 2019
0.932 Impact Factor

Stomatin plays a suppressor role in non-small cell lung cancer metastasis.

Chin J Cancer Res 2019 Dec;31(6):930-944

Center of Biotherapy, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Objective: Metastasis is one of the key causes of high mortality in lung cancer. Aberrant DNA methylation is a common event in metastatic lung cancer. We aimed to identify new epigenetic regulation of metastasis-associated genes and characterize their effects on lung cancer progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955161PMC
December 2019

Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm.

Chin J Cancer Res 2019 Dec;31(6):918-929

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: Neuroendocrine neoplasms (NENs) are relatively rare and heterogeneous malignancies with two major subtypes: low-grade neuroendocrine tumor (NET) and high-grade neuroendocrine carcinoma (NEC). Comprehensive molecular characterization of NENs is needed to refine our understanding of the biological underpinnings of different NEN subtypes and to predict disease progression more accurately.

Methods: We performed whole-exome sequencing (WES) of NEN samples from 49 patients (25 NETs and 24 NECs) arising from the stomach, intestines or lung. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955168PMC
December 2019

Efficacy of irinotecan-based chemotherapy after exposure to an anti-PD-1 antibody in patients with advanced esophageal squamous cell carcinoma.

Chin J Cancer Res 2019 Dec;31(6):910-917

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: Several anti-programmed cell death 1 (anti-PD-1) antibodies have demonstrated potential efficacy in the treatment of advanced esophageal squamous cell cancer (ESCC). However, the response to subsequent chemotherapy after the failure of PD-1 blockade in ESCC patients has not been reported, and the optimal sequencing of immunotherapy and chemotherapy remains controversial. The aim of the present study was to evaluate responses to irinotecan-based subsequent chemotherapy in advanced ESCC patients who had progressed after treatment with camrelizumab (SHR-1210), a novel anti-PD-1 antibody. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955162PMC
December 2019
0.932 Impact Factor

CDK6 inhibits lymphoid cell infiltration and represents a prognostic marker in HPV+ squamous cell carcinoma of head and neck.

Chin J Cancer Res 2019 Dec;31(6):901-909

Department of Medical Oncology, Peking University International Hospital, Beijing 102206, China.

Objective: We investigated the correlations between cyclin-dependent kinase 4/6 (CDK4/6) levels and human papillomavirus (HPV) infection state in head and neck squamous cell cancer (HNSCC). The aim was to explore the potential value of CDK4/6 inhibitors in the treatment of HNSCC.

Methods: Multiomic sequencing data for HNSCC were obtained from The Cancer Genome Atlas (TCGA), and the mRNA levels and copy number variations (CNVs) of CDK4 and CDK6 were strictly analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955169PMC
December 2019
0.932 Impact Factor

Implications of clinical research on adjuvant chemotherapy for gastric cancer: Where to go next?

Chin J Cancer Res 2019 Dec;31(6):892-900

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Postoperative adjuvant chemotherapy (ACT) confers superior gastric cancer (GC) survival in the Eastern cohort. However, is the current standard of ACT already excessive, or is it still necessary to increase its intensity for specific subgroups? Tailored ACT strategies for GC depend on gradual exploration by clinical trials in selected patients. Thus, understanding the implications of previous and current research can help us respond wisely and design effective, rational trials, save medical resources and make better decisions in clinical practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955166PMC
December 2019

Can trastuzumab emtansine be replaced by additional chemotherapy plus targeted therapy for HER2-overexpressing breast cancer patients with residual disease after neoadjuvant chemotherapy?

Chin J Cancer Res 2019 Dec;31(6):878-891

Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is an aggressive phenotype with a poor prognosis, and can easily metastasize and recur. Currently, chemotherapy plus HER2-targeted therapy is the standard systemic treatment for most of these patients. Given that neoadjuvant chemotherapy (NAC) has an efficacy equivalent to that of adjuvant chemotherapy and some additional benefits, many patients, especially those with more advanced tumors, prefer NAC and generally will not receive additional chemotherapy after surgery, irrespective of the pathological response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955160PMC
December 2019

Pancreatic head cancer: Open or minimally invasive pancreaticoduodenectomy?

Chin J Cancer Res 2019 Dec;31(6):862-877

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Pancreatic head cancer still represents an insurmountable barrier for patients and pancreatic surgeons. Pancreaticoduodenectomy (PD) continues to be the operative standard of care and potentially curative procedure for pancreatic head cancer. Despite the rapid development of minimally invasive techniques, whether the efficacy of minimally invasive pancreaticoduodenectomy (MIPD) is noninferior or superior to open pancreaticoduodenectomy (OPD) remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955167PMC
December 2019

Challenges of evaluating immunotherapy efficacy in solid tumors.

Chin J Cancer Res 2019 Dec;31(6):853-861

Cancer Center, the First Hospital of Jilin University, Jilin 130021, China.

Immunotherapy is one of the most promising treatments for multiple tumor types. The significant clinical benefits and durable responses of immunotherapy have led to the emergence of various immune-related clinical response patterns that extend beyond those achieved with cytotoxic agents. Various studies investigated the efficacy of immunotherapy, including the effect on tumor size, long-term survival benefits, and the ability to overcome the particularly challenging survival curves tailing phenomenon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955172PMC
December 2019

Short-course or long-course radiation therapy as a part of a neoadjuvant regimen for stage II & III rectal adenocarcinoma?

Chin J Cancer Res 2019 Dec;31(6):849-852

Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

The aim of this mini-review is to compare and contrast the pros and cons of short-course and long-course neoadjuvant chemoradiation therapy regimens for stage II & III rectal adenocarcinoma. Multiple trials have demonstrated the equal efficacy and safety of short-course and long-course radiation therapy as a part of neoadjuvant regimens. Published data also shows that total neoadjuvant therapy could be more successful than neoadjuvant chemoradiation followed by adjuvant chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.06.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955171PMC
December 2019

A study on service capacity of primary medical and health institutions for cervical cancer screening in urban and rural areas in China.

Chin J Cancer Res 2019 Oct;31(5):838-848

Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: To provide a decision-making basis for sustainable and effective development of cervical cancer screening.

Methods: This cross-sectional study assesses the service capacity to conduct cervical cancer screening with a sample of 310 medical staff, medical institutions and affiliated township health centers from 20 county-level/district-level areas in 14 Chinese provinces in 2016.

Results: The county-level/district-level institutions were the main prescreening institutions for cervical cancer screening. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856697PMC
October 2019
0.932 Impact Factor

Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 20022011.

Chin J Cancer Res 2019 Oct;31(5):825-837

Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: Colorectal cancer (CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.

Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856700PMC
October 2019

Surgical outcomes of hand-assisted laparoscopic liver resection . open liver resection: A retrospective propensity score-matched cohort study.

Chin J Cancer Res 2019 Oct;31(5):818-824

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: Hand-assisted laparoscopic liver resection has the advantages of open and laparoscopic surgeries. There is still lack of comparison of surgical outcomes between hand-assistied laparoscopic liver resection (HALLR) and open liver resection (OLR). This study compared the surgical outcomes of the two approaches between well-matched patient cohorts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856709PMC
October 2019

Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study.

Chin J Cancer Res 2019 Oct;31(5):806-817

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To investigate the value of whole-lesion texture analysis on preoperative gadoxetic acid enhanced magnetic resonance imaging (MRI) for predicting tumor Ki-67 status after curative resection in patients with hepatocellular carcinoma (HCC).

Methods: This study consisted of 89 consecutive patients with surgically confirmed HCC. Texture features were extracted from multiparametric MRI based on whole-lesion regions of interest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856708PMC
October 2019

Machine-learning-assisted prediction of surgical outcomes in patients undergoing gastrectomy.

Chin J Cancer Res 2019 Oct;31(5):797-805

Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.

Objective: Postoperative complications adversely affected the prognosis in patients with gastric cancer. This study intends to investigate the feasibility of using machine-learning model to predict surgical outcomes in patients undergoing gastrectomy.

Methods: In this study, cancer patients who underwent gastrectomy at Shanghai Rui Jin Hospital in 2017 were randomly assigned to a development or validation cohort in a 9:1 ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856706PMC
October 2019

Prognostic significance of lymphovascular infiltration in overall survival of gastric cancer patients after surgery with curative intent.

Chin J Cancer Res 2019 Oct;31(5):785-796

Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.

Objective: Lymphovascular infiltration (LVI) is frequently detected in gastric cancer (GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without LVI.

Methods: In total, 1,007 patients with curatively resected GC at Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were retrospectively enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856698PMC
October 2019
0.932 Impact Factor

Phosphoglucose isomerase gene expression as a prognostic biomarker of gastric cancer.

Chin J Cancer Res 2019 Oct;31(5):771-784

Centre for Cognitive Machines and Computational Health (CMaCH), School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Objective: Tumor heterogeneity renders identification of suitable biomarkers of gastric cancer (GC) challenging. Here, we aimed to identify prognostic genes of GC using computational analysis.

Methods: We first used microarray technology to profile gene expression of GC and paired nontumor tissues from 198 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856704PMC
October 2019

Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-positive early-stage breast cancer: A real-world retrospective study in Chinese patients.

Chin J Cancer Res 2019 Oct;31(5):759-770

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: To assess the long-term effectiveness and safety of trastuzumab in adjuvant therapy for Chinese patients with early-stage human epidermal growth factor 2 (HER2)-positive breast cancer in a real-world setting.

Methods: This retrospective observational study analyzed the medical records of HER2-positive breast cancer patients between 2000 and 2012 at the Chinese Academy of Medical Sciences. Patients who received adjuvant chemotherapy alone or adjuvant chemotherapy followed by/combined with trastuzumab were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856699PMC
October 2019

First-line pemetrexed-platinum doublet chemotherapy with or without bevacizumab in non-squamous non-small cell lung cancer: A real-world propensity score-matched study in China.

Chin J Cancer Res 2019 Oct;31(5):749-758

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

Objective: To evaluate the efficacy and safety profile of first-line bevacizumab (Bev)-containing pemetrexed-platinum chemotherapy in a real-world Chinese cohort with advanced non-squamous non-small cell lung cancer (NS-NSCLC).

Methods: A total of 415 eligible patients with NS-NSCLC who received first-line pemetrexed-platinum chemotherapy at National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between February 2010 and September 2017 were reviewed retrospectively: 309 Bev(-) and 106 Bev(+) cases. Bev was administered at 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856705PMC
October 2019

Effect of intraoperative fluid administration on perioperative outcomes in patients undergoing McKeown esophagogastrectomy.

Chin J Cancer Res 2019 Oct;31(5):742-748

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: Fluid therapy is one of the key components of perioperative management. However, evidence of intraoperative fluid (IOF) administration affecting clinical outcomes following McKeown esophagogastrectomy remains limited. This study investigated the impact of IOF on clinical outcomes after McKeown esophagogastrectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.05.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856707PMC
October 2019
0.932 Impact Factor