3,153 results match your criteria Chinese journal of cancer[Journal]


Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy.

Chin J Cancer 2018 01 31;37(1). Epub 2018 Jan 31.

Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing, 100021, P. R. China.

Background: Autophagy plays a crucial role in chemotherapy resistance of triple-negative breast cancer (TNBC). Hence, autophagy-related gene 5 (ATG5), an essential molecule involved in autophagy regulation, is presumably associated with recurrence of TNBC. This study was aimed to investigate the potential influence of single-nucleotide polymorphisms in ATG5 on the disease-free survival (DFS) of early-stage TNBC patients treated with anthracycline- and/or taxane-based chemotherapy. Read More

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http://dx.doi.org/10.1186/s40880-018-0268-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791378PMC
January 2018
16 Reads

Computed tomography and magnetic resonance imaging evaluation of pelvic lymph node metastasis in bladder cancer.

Chin J Cancer 2018 01 26;37(1). Epub 2018 Jan 26.

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong, P. R. China.

Background: Accurate evaluation of lymph node metastasis in bladder cancer (BCa) is important for disease staging, treatment selection, and prognosis prediction. In this study, we aimed to evaluate the diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) for metastatic lymph nodes in BCa and establish criteria of imaging diagnosis.

Methods: We retrospectively assessed the imaging characteristics of 191 BCa patients who underwent radical cystectomy. Read More

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http://dx.doi.org/10.1186/s40880-018-0269-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785867PMC
January 2018
6 Reads

The 150 most important questions in cancer research and clinical oncology series: questions 86-93 : Edited by Chinese Journal of Cancer.

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Chin J Cancer 2018 01 22;37(1). Epub 2018 Jan 22.

Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which spark diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 8 more questions are presented as follows. Question 86. Read More

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http://dx.doi.org/10.1186/s40880-018-0266-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778741PMC
January 2018
3 Reads

Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.

Chin J Cancer 2018 01 22;37(1). Epub 2018 Jan 22.

Department of Epidemiology, Second Military Medical University, Shanghai, 200433, P. R. China.

Background: We previously showed that the expression of follistatin-like protein 1 (FSTL1) was significantly down-regulated in metastatic clear-cell renal cell carcinoma (ccRCC). In this study, we aimed to characterize the role of FSTL1 in the development of ccRCC.

Methods: The effects of FSTL1 on cell activity and cell cycle were investigated in ccRCC cell lines with altered FSTL1 expression. Read More

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http://dx.doi.org/10.1186/s40880-018-0267-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778637PMC
January 2018
35 Reads

Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma.

Chin J Cancer 2017 12 29;36(1):98. Epub 2017 Dec 29.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, P. R. China.

Background: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment serum copy number of Epstein-Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients. Read More

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http://dx.doi.org/10.1186/s40880-017-0264-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747160PMC
December 2017
22 Reads

Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial.

Chin J Cancer 2017 12 22;36(1):97. Epub 2017 Dec 22.

Department of Epidemic and Health Statistics, Nanjing Medical University, Nanjing, 211166, Jiangsu, P. R. China.

Background: Metastatic colorectal cancer (mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, with promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in mCRC. Read More

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http://dx.doi.org/10.1186/s40880-017-0263-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741870PMC
December 2017
34 Reads

Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage III colon cancer.

Chin J Cancer 2017 12 21;36(1):96. Epub 2017 Dec 21.

Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, P. R. China.

Background: The prognostic nutritional index (PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. Although a low PNI predicts poor prognosis in patients with colorectal cancer after tumor resection, the prognostic value remains unknown in patients with stage III colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy. This study aimed to investigate the prognostic value of PNI in patients with stage III colon cancer. Read More

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http://dx.doi.org/10.1186/s40880-017-0260-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740941PMC
December 2017
13 Reads

Significant value of F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.

Chin J Cancer 2017 Dec 19;36(1):95. Epub 2017 Dec 19.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.

Background: Little is known about the nature of metastasis to small cervical lymph nodes (SCLNs) in the patients with nasopharyngeal carcinoma (NPC) examined by using 18-fluoro-2-deoxy-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT). The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.

Methods: Magnetic resonance images (MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Read More

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http://dx.doi.org/10.1186/s40880-017-0265-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738123PMC
December 2017
27 Reads

Expression and clinical value of programmed cell death-ligand 1 (PD-L1) in diffuse large B cell lymphoma: a retrospective study.

Chin J Cancer 2017 Dec 16;36(1):94. Epub 2017 Dec 16.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.

Background: The programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway inhibits the activation of T cells and plays a crucial role in the negative regulation of cellular and humoral immune responses. Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. In the present study, we aimed to detect the expression of PD-L1 in DLBCL and to analyze its relationship with prognosis. Read More

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http://dx.doi.org/10.1186/s40880-017-0262-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732416PMC
December 2017
9 Reads

Survival and prognostic factors of non-small cell lung cancer patients with postoperative locoregional recurrence treated with radical radiotherapy.

Chin J Cancer 2017 Dec 11;36(1):93. Epub 2017 Dec 11.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, P. R. China.

Background: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical radiotherapy.

Methods: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2012 and February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China). Read More

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http://dx.doi.org/10.1186/s40880-017-0261-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725840PMC
December 2017
13 Reads

International Szent-Györgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer.

Chin J Cancer 2017 Nov 21;36(1):92. Epub 2017 Nov 21.

National Foundation for Cancer Research, 4600 East West Highway, Suite 525, Bethesda, MD, 20814, USA.

The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer research globally with the ultimate goal to cure cancer. The coveted Szent-Györgyi Prize annually honors a scientist whose seminal discovery or body of work has resulted in, or led toward, notable contributions to cancer prevention, diagnosis, or treatment; and the discovery has had a high direct impact of saving people's lives. In addition, the prize promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. Read More

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http://dx.doi.org/10.1186/s40880-017-0258-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697018PMC
November 2017
7 Reads

The 150 most important questions in cancer research and clinical oncology series: questions 76-85 : Edited by Chinese Journal of Cancer.

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Chin J Cancer 2017 Nov 20;36(1):91. Epub 2017 Nov 20.

Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. Read More

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http://dx.doi.org/10.1186/s40880-017-0259-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694899PMC
November 2017
4 Reads

Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes.

Chin J Cancer 2017 Nov 9;36(1):89. Epub 2017 Nov 9.

Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China.

Background: Voltage-gated sodium channel 1.5 (Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Read More

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http://dx.doi.org/10.1186/s40880-017-0253-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679318PMC
November 2017
19 Reads

Nasopharyngeal carcinoma incidence and mortality in China, 2013.

Chin J Cancer 2017 Nov 9;36(1):90. Epub 2017 Nov 9.

National Central Cancer Registry, National Cancer Center, Beijing, 100021, P. R. China.

Background: We estimated the incidence and mortality of nasopharyngeal carcinoma (NPC) in China in 2010 according to the data of 145 domestic population-based cancer registries in 2014, and no such reports since then. Hence, to further and better understand its epidemiology in China and to provide more precise scientific information for its control and prevention in China, we analyzed the NPC incidence and mortality of 255 domestic population-based cancer registries, and estimated the national rates in 2013 again.

Methods: NPC incidence and mortality data of 255 domestic cancer registries in 2013, accepted by the 2016 National Cancer Registry Annual Report, were collected and collated, and the indices of NPC such as the numbers of new cases and deaths, crude rates, age-standardized rates, and truncated rates of incidence and mortality were calculated and analyzed. Read More

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http://dx.doi.org/10.1186/s40880-017-0257-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679327PMC
November 2017
3 Reads

Systematic analyses of glutamine and glutamate metabolisms across different cancer types.

Chin J Cancer 2017 Nov 7;36(1):88. Epub 2017 Nov 7.

College of Computer Science and Technology, Jilin University, Changchun, 130012, Jilin, P. R. China.

Background: Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such knowledge could be critical for understanding the distinct characteristics of different cancer types. Our computational study aimed to examine the functional roles of glutamine and glutamate across different cancer types. Read More

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http://dx.doi.org/10.1186/s40880-017-0255-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678792PMC
November 2017
4 Reads

Prognostic value of plasma Epstein-Barr virus DNA level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy.

Chin J Cancer 2017 Nov 7;36(1):87. Epub 2017 Nov 7.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China.

Background: The value of Epstein-Barr virus (EBV) DNA assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma (NPC) presenting with different pretreatment plasma EBV DNA levels remains unclear. In the present study, we aimed to evaluate the prognostic value of plasma EBV DNA assay during posttreatment follow-up in the patients with NPC who have undergone intensity-modulated radiotherapy.

Methods: The medical records of 385 NPC patients treated with intensity-modulated radiotherapy between November 2009 and February 2012 were reviewed. Read More

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http://dx.doi.org/10.1186/s40880-017-0256-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678814PMC
November 2017
26 Reads

The 150 most important questions in cancer research and clinical oncology series: questions 67-75 : Edited by Chinese Journal of Cancer.

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Chin J Cancer 2017 Nov 1;36(1):86. Epub 2017 Nov 1.

Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. Read More

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http://dx.doi.org/10.1186/s40880-017-0254-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664810PMC
November 2017
2 Reads

Conditional survival in patients with gallbladder cancer.

Chin J Cancer 2017 Oct 30;36(1):85. Epub 2017 Oct 30.

Department of Radiation Oncology, Ewha Womans University College of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, Republic of Korea.

Background: Conditional survival (CS) has been established as a clinically relevant prognostic factor for cancer survivors, and the CS in gallbladder (GB) cancer has not yet been fully evaluated. In this study, we evaluated the cancer-specific CS rate and cancer-specific survival (CSS) rate in patients with GB cancer at multiple time points and investigated prognostic factors which affect cancer-specific CS rate to provide more accurate survival information.

Methods: Between 2004 and 2013, a total of 9760 patients with GB cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) data. Read More

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http://dx.doi.org/10.1186/s40880-017-0252-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663056PMC
October 2017
4 Reads

The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital-based multi-center study.

Chin J Cancer 2017 Oct 25;36(1):84. Epub 2017 Oct 25.

National Office for Cancer Prevention and Control & National Central Cancer Registry, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P. R. China.

Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China. To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China. Read More

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http://dx.doi.org/10.1186/s40880-017-0250-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657106PMC
October 2017
19 Reads

Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: a prospective non-randomized study.

Chin J Cancer 2017 Oct 23;36(1):83. Epub 2017 Oct 23.

Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China.

Background: Transarterial chemoembolization (TACE) is recommended as the standard care for unresectable hepatocellular carcinoma (HCC) at Barcelona Clinic Liver Cancer (BCLC) stage A-B. However, the efficacy of TACE on large (≥ 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy (HAIC) might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX (mFOLFOX) regimen and those of TACE in patients with massive unresectable HCC. Read More

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http://dx.doi.org/10.1186/s40880-017-0251-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654007PMC
October 2017
8 Reads

Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study.

Chin J Cancer 2017 Oct 16;36(1):81. Epub 2017 Oct 16.

Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, P. R. China.

Background: The prognostic role of the V600E mutation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) in metastatic colorectal cancer (mCRC) is well established, but the therapeutic regimen targeting this disease is lacking. This study aimed to analyze the clinicopathologic features of and treatment efficacy of commonly used regimens on BRAF-mutated mCRCs.

Methods: We collected and reviewed the medical records of mCRC patients treated at Peking University Cancer Hospital & Institute (Beijing, China) between July 2011 and July 2016. Read More

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http://dx.doi.org/10.1186/s40880-017-0247-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644136PMC
October 2017
96 Reads

Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression.

Chin J Cancer 2017 10 16;36(1):82. Epub 2017 Oct 16.

Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P. R. China.

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http://dx.doi.org/10.1186/s40880-017-0248-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644172PMC
October 2017
7 Reads

The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.

Chin J Cancer 2017 Oct 11;36(1):80. Epub 2017 Oct 11.

Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 30060, P. R. China.

Background: Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor (MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values.

Methods: CXCR4, CXCL12, and Cyclin D1 protein expression in samples from 58 Chinese patients with sporadic MPNST was assessed with immunohistochemical staining. Read More

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http://dx.doi.org/10.1186/s40880-017-0246-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637246PMC
October 2017
8 Reads

The 150 most important questions in cancer research and clinical oncology series: questions 57-66 : Edited by Chinese Journal of Cancer.

Authors:

Chin J Cancer 2017 Oct 3;36(1):79. Epub 2017 Oct 3.

Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 57. Read More

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http://dx.doi.org/10.1186/s40880-017-0249-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627450PMC
October 2017
43 Reads

Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases.

Chin J Cancer 2017 Oct 2;36(1):78. Epub 2017 Oct 2.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, P. R. China.

Background: Pathologic response is evaluated according to the extent of tumor regression and is used to estimate the efficacy of preoperative treatment. Several studies have reported the association between the pathologic response and clinical outcomes of colorectal cancer patients with liver metastases who underwent hepatectomy. However, to date, no data from Chinese patients have been reported. Read More

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http://dx.doi.org/10.1186/s40880-017-0244-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625647PMC
October 2017
60 Reads

Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer.

Chin J Cancer 2017 Sep 26;36(1):77. Epub 2017 Sep 26.

Department of Biotherapy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.

Background: Reduced expression of tripartite motif-containing 3 (TRIM3) has been reported to be involved in the pathogenesis of human glioblastoma. In our previous research, we found that TRIM3 expression was markedly reduced in human primary hepatocellular carcinoma (HCC) tissues and that low TRIM3 expression was associated with short survival of HCC patients. However, the role of TRIM3 in liver cancer remains unknown. Read More

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http://dx.doi.org/10.1186/s40880-017-0240-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615435PMC
September 2017
23 Reads

Effects of dosimetric inadequacy on local control and toxicities in the patients with T4 nasopharyngeal carcinoma extending into the intracranial space and treated with intensity-modulated radiotherapy plus chemotherapy.

Chin J Cancer 2017 Sep 20;36(1):76. Epub 2017 Sep 20.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P. R. China.

Background: To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we aimed to evaluate the effect of dosimetric inadequacy on local control and late neurological toxicities for patients treated with intensity-modulated radiotherapy (IMRT) plus chemotherapy.

Methods: We prospectively enrolled patients who had non-metastatic T4 NPC with intracranial extension treated between January 2009 and November 2013. Read More

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https://cancercommun.biomedcentral.com/articles/10.1186/s408
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http://dx.doi.org/10.1186/s40880-017-0245-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607564PMC
September 2017
4 Reads

Prognostic value of systemic immune-inflammation index in patients with gastric cancer.

Chin J Cancer 2017 Sep 12;36(1):75. Epub 2017 Sep 12.

Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, P. R. China.

Background: Inflammation-based indexes have been used to predict survival and recurrence in cancer patients. Systemic immune-inflammation index (SII) was reported to be associated with prognosis in some malignant tumors. In the present study, we aimed to explore the association between SII and the prognosis of patients with gastric cancer. Read More

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http://dx.doi.org/10.1186/s40880-017-0243-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596912PMC
September 2017
19 Reads

Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial.

Chin J Cancer 2017 Sep 11;36(1):74. Epub 2017 Sep 11.

Department of Hematology-Oncology, Gyeongsang National University Hospital, Jinju, 52727, South Korea.

Background: Controlled-release oxycodone/naloxone (OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone (OX-CR) for the control of cancer-related pain in Korean patients.

Methods: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale (NRS) pain score ≥4] from seven Korean oncology/hematology centers. Read More

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http://dx.doi.org/10.1186/s40880-017-0241-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594448PMC
September 2017
52 Reads

Medical expenditure for esophageal cancer in China: a 10-year multicenter retrospective survey (2002-2011).

Chin J Cancer 2017 Sep 7;36(1):73. Epub 2017 Sep 7.

Program Office for Cancer Screening in Urban China, Cancer Hospital, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College, National Cancer Center of China, No. 17 Panjiayuannanli, Chaoyang District, Beijing, 100021, P. R. China.

Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends. Read More

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https://cancercommun.biomedcentral.com/articles/10.1186/s408
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http://dx.doi.org/10.1186/s40880-017-0242-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590174PMC
September 2017
73 Reads

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera.

Chin J Cancer 2017 Sep 6;36(1):72. Epub 2017 Sep 6.

Department of Urology, QiLu Hospital, Shandong University, Jinan, 250012, Shandong, P. R. China.

Background: Erythrocytosis, a rare paraneoplastic syndrome, generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma.

Case Presentation: We report a case of a young man suffering from a giant (22-cm) mass on his left kidney. Because of a history of polycythemia vera, the patient had been treated for the condition for 9 years. Read More

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https://cancercommun.biomedcentral.com/articles/10.1186/s408
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http://dx.doi.org/10.1186/s40880-017-0238-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588672PMC
September 2017
35 Reads

Potential factors associated with clinical stage of nasopharyngeal carcinoma at diagnosis: a case-control study.

Chin J Cancer 2017 Sep 4;36(1):71. Epub 2017 Sep 4.

School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, P. R. China.

Background: In China, most patients with nasopharyngeal carcinoma (NPC) are diagnosed at a late stage and consequently have a poor prognosis. This study aimed to investigate potential factors associated with the clinical stage of NPC at diagnosis.

Methods: Data were obtained from 118 patients with early-stage NPC and 274 with late-stage NPC who were treated at Sun Yat-sen University Cancer Center between August 2014 and July 2015. Read More

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https://cancercommun.biomedcentral.com/articles/10.1186/s408
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http://dx.doi.org/10.1186/s40880-017-0239-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584009PMC
September 2017
17 Reads

Erratum to: Cancer chemoprevention through dietary flavonoids: what's limiting?

Chin J Cancer 2017 08 30;36(1):70. Epub 2017 Aug 30.

Department of Pharmacology and Systems Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43560, USA.

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http://dx.doi.org/10.1186/s40880-017-0237-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576239PMC
August 2017
7 Reads

The 150 most important questions in cancer research and clinical oncology series: questions 50-56.

Authors:

Chin J Cancer 2017 Aug 29;36(1):69. Epub 2017 Aug 29.

Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, seven more questions are presented as followed. Question 50. Read More

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http://dx.doi.org/10.1186/s40880-017-0236-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574233PMC
August 2017
31 Reads

At-home cancer screening: a solution for China and other developing countries with a large population and limited number of healthcare practitioners.

Authors:
Chao-Nan Qian

Chin J Cancer 2017 Aug 21;36(1):68. Epub 2017 Aug 21.

Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.

Five-year survival rate for patients with all cancers combined, in China, is only 30.9%, which is much lower than those in developed countries. The three main reasons for the low cancer curative rates in China include differences in the spectrum of cancer types, in early detection rates, and in the percentage of cancer patients receiving standardized treatment between China and developed countries. Read More

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http://dx.doi.org/10.1186/s40880-017-0235-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563903PMC
August 2017
2 Reads

Awakening immunity against cancer: a 2017 primer for clinicians.

Chin J Cancer 2017 Aug 20;36(1):67. Epub 2017 Aug 20.

National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.

Cancer immunotherapy has finally joined the pillars of cancer treatment-surgery, radiation, chemotherapy, hormonal therapy, and targeted therapy-in improving cancer patient lives. In the last 5 years, the development of immune checkpoint inhibitor and T cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy, has been remarkable for the speed, scale, and number of drug approvals. Still, these treatments may also bring unusual adverse effects and clinical outcomes including unprecedented long-term survival. Read More

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http://dx.doi.org/10.1186/s40880-017-0233-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563384PMC
August 2017
46 Reads

Estimates of cancer incidence and mortality in China, 2013.

Chin J Cancer 2017 Aug 17;36(1):66. Epub 2017 Aug 17.

National Central Cancer Registry, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P. R. China.

Introduction: Population-based cancer registration data are collected by the National Central Cancer Registry in China every year. Cancer incident cases and cancer deaths in 2013 were analyzed.

Methods: Through the procedure of quality control, reported data from 255 registries were accepted to establish the national database for cancer estimates. Read More

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http://dx.doi.org/10.1186/s40880-017-0234-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561600PMC
August 2017
64 Reads

Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review.

Chin J Cancer 2017 Aug 17;36(1):65. Epub 2017 Aug 17.

Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Science Building, No.17 Panjiayuan Nanli, Chaoyang District, PO Box 2258, Beijing, 100021, P. R. China.

Background: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy, with a high incidence and poor prognosis. In the past several decades, hundreds of proteins have been reported to be associated with the prognosis of ESCC, but none has been widely accepted to guide clinical care. This study aimed to identify proteins with great potential for predicting prognosis of ESCC. Read More

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http://dx.doi.org/10.1186/s40880-017-0232-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561640PMC
August 2017
102 Reads

Comparison of efficacy, safety, and quality of life between sorafenib and sunitinib as first-line therapy for Chinese patients with metastatic renal cell carcinoma.

Chin J Cancer 2017 Aug 8;36(1):64. Epub 2017 Aug 8.

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Rd., Pudong District, Shanghai, 200127, P. R. China.

Background: Sorafenib and sunitinib are widely used as first-line targeted therapy for metastatic renal cell carcinoma (mRCC) in China. This study aimed to compare the efficacy, safety, and quality of life (QoL) in Chinese mRCC patients treated with sorafenib and sunitinib as first-line therapy.

Methods: Clinical data of patients with mRCC who received sorafenib (400 mg twice daily; 4 weeks) or sunitinib (50 mg twice daily; on a schedule of 4 weeks on treatment followed by 2 weeks off) were retrieved. Read More

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http://dx.doi.org/10.1186/s40880-017-0230-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547674PMC
August 2017
26 Reads

Prognostic role of ABO blood type in patients with extranodal natural killer/T cell lymphoma, nasal type: a triple-center study.

Chin J Cancer 2017 Jul 31;36(1):62. Epub 2017 Jul 31.

Department of Medical Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, 651 Dong Feng RD East, Guangdong, 510060, Guangdong, P. R. China.

Background: The prognostic significance of ABO blood type for lymphoma is largely unknown. We evaluated the prognostic role of ABO blood type in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL).

Methods: We retrospectively analyzed clinical data of 697 patients with newly diagnosed ENKTL from three cancer centers. Read More

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http://dx.doi.org/10.1186/s40880-017-0229-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535286PMC
July 2017
7 Reads

Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.

Chin J Cancer 2017 Jul 31;36(1):63. Epub 2017 Jul 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510507, Guangdong, P. R. China.

Background: The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes responsible for resistance to trametinib in CRC cells, using a synthetic lethal short hairpin RNA (shRNA) screening approach. Read More

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http://dx.doi.org/10.1186/s40880-017-0228-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535279PMC
July 2017
42 Reads

Spatio-temporal analysis of the incidence of colorectal cancer in Guangzhou, 2010-2014.

Chin J Cancer 2017 Jul 28;36(1):60. Epub 2017 Jul 28.

Department of Biostatistics and Cancer Registration, Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, Guangdong, P. R. China.

Introduction: Colorectal cancer (CRC) is a common type of neoplasm. This study examined the spatio-temporal distribution of the CRC incidence in Guangzhou during 2010-2014.

Methods: Colorectal cancer incidence data were obtained from the Guangzhou Cancer Registry System. Read More

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http://dx.doi.org/10.1186/s40880-017-0231-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534053PMC
July 2017
10 Reads

Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma.

Chin J Cancer 2017 Jul 29;36(1):61. Epub 2017 Jul 29.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, P. R. China.

Background: Anti-programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra- and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy. Read More

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https://cancercommun.biomedcentral.com/articles/10.1186/s408
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http://dx.doi.org/10.1186/s40880-017-0226-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534127PMC
July 2017
79 Reads

Transarterial chemoembolization combined with recombinant human adenovirus type 5 H101 prolongs overall survival of patients with intermediate to advanced hepatocellular carcinoma: a prognostic nomogram study.

Chin J Cancer 2017 Jul 20;36(1):59. Epub 2017 Jul 20.

Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.

Background: Patients with intermediate to advanced hepatocellular carcinoma (HCC) are most commonly treated with transarterial chemoembolization (TACE). Previous studies showed that TACE combined with recombinant human adenovirus type 5 (H101) may provide a clinical survival benefit. In the present study, we aimed to determine the survival benefit of TACE with or without H101 for patients with intermediate to advanced HCC and to develop an effective nomogram for predicting individual survival outcomes of these patients. Read More

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http://dx.doi.org/10.1186/s40880-017-0227-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518415PMC
July 2017
15 Reads

Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China: a decision analysis and implications for practice.

Chin J Cancer 2017 Jul 14;36(1):57. Epub 2017 Jul 14.

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, P. R. China.

Background: Mortality outcomes in trials of low-dose computed tomography (CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.

Methods: A decision tree model with three scenarios (low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort (100,000 smokers aged 45-80 years). Read More

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http://dx.doi.org/10.1186/s40880-017-0221-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512753PMC
July 2017
26 Reads

Radiotherapy among nonagenarians with anal or rectal carcinoma: should we avoid or adapt treatment?

Chin J Cancer 2017 07 14;36(1):56. Epub 2017 Jul 14.

Department of Radiotherapy, Lucien Neuwirth Cancer Institute, 108 Bis, Avenue Albert-Raimond, BP 60008, 42271, Saint-Priest En Jarez, France.

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http://dx.doi.org/10.1186/s40880-017-0224-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512941PMC
July 2017
57 Reads

Immune evasion might affect survival in laryngeal cancer patients with blood group O.

Authors:
Kadri Altundag

Chin J Cancer 2017 07 12;36(1):54. Epub 2017 Jul 12.

MKA Breast Cancer Clinic, Tepe Prime, Cankaya, 06800, Ankara, Turkey.

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http://dx.doi.org/10.1186/s40880-017-0223-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508755PMC
July 2017
1 Read

The 150 most important questions in cancer research and clinical oncology series: questions 40-49.

Authors:

Chin J Cancer 2017 Jul 13;36(1):55. Epub 2017 Jul 13.

Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 40. Read More

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http://dx.doi.org/10.1186/s40880-017-0222-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508686PMC
July 2017
22 Reads

Different dissecting orders of the pulmonary bronchus and vessels during right upper lobectomy are associated with surgical feasibility and postoperative recovery for lung cancer patients.

Chin J Cancer 2017 Jun 27;36(1):53. Epub 2017 Jun 27.

Graduate School, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.

Background: Right upper lobectomy (RUL) for lung cancer with different dissecting orders involves the most variable anatomical structures, but no studies have analyzed its effects on postoperative recovery. This study compared the conventional surgical approach, VAB (dissecting pulmonary vessels first, followed by the bronchus), and the alternative surgical approach, aBVA (dissecting the posterior ascending arterial branch first, followed by the bronchus and vessels) on improving surgical feasibility and postoperative recovery for lung cancer patients.

Methods: According to the surgical approach, consecutive lung cancer patients undergoing RUL were grouped into aBVA and VAB cohorts. Read More

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http://dx.doi.org/10.1186/s40880-017-0220-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488305PMC
June 2017
43 Reads