370 results match your criteria Chinese Medicine [Journal]


Cellular stress response mechanisms of Rhizoma coptidis: a systematic review.

Chin Med 2018 7;13:27. Epub 2018 Jun 7.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Road, Wenjiang District, Chengdu, 611137 China.

Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. Alkaloids, especially berberine, coptisine and palmatine, are responsible for multiple pharmacological effects of Rhizoma coptidis. Read More

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June 2018
2 Reads

Clarifying the origin of Houzao.

Chin Med 2018 3;13:25. Epub 2018 May 3.

School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

Background: Houzao (bezoar) is a valuable imported Chinese medicine that is commonly used as a pediatric medicine to transform phlegm. There are mainly two types of Houzao, "Southeast Asian Houzao" and "Indian Houzao". "Indian Houzao" is the dominant commercial product accounts for over 95% of the actual utilization in the market. Read More

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Pharmacokinetics of Chinese medicines: strategies and perspectives.

Chin Med 2018 2;13:24. Epub 2018 May 2.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.

The modernization and internationalization of Chinese medicines (CMs) are hampered by increasing concerns on the safety and the efficacy. Pharmacokinetic (PK) study is indispensable to establish concentration-activity/toxicity relationship and facilitate target identification and new drug discovery from CMs. To cope with tremendous challenges rooted from chemical complexity of CMs, the classic PK strategies have evolved rapidly from PK study focusing on marker/main drug components to PK-PD correlation study adopting metabolomics approaches to characterize associations between disposition of global drug-related components and host metabolic network shifts. Read More

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May 2018
1 Read

Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity.

Chin Med 2018 23;13:23. Epub 2018 Apr 23.

3Wadsworth Center, New York State Department of Health, 1400 Washington Ave, Albany, NY USA.

Background: Triptolide, an active ingredient of Chinese medicine plant Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. Read More

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Comparative study of the polyphenol content-related anti-inflammatory and antioxidant activities of two specimens from different geographical areas.

Chin Med 2018 19;13:22. Epub 2018 Apr 19.

Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.

Background: is an Argentinean species that has been traditionally used to treat symptoms of inflammation. The aim of this study was to determine and compare the anti-inflammatory and antioxidant effects of two specimens of obtained in the provinces of Salta and Misiones, which are two different geographical areas of Argentina.

Methods: The anti-inflammatory activity of the extracts was tested in LPS-stimulated macrophages through the DPPH radical scavenging activity, the SOD-like activity, the reducing power and the inhibition of lipid peroxidation. Read More

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Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS.

Chin Med 2018 18;13:21. Epub 2018 Apr 18.

1The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases With TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing, 100029 China.

Background: Eosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to observe the effect of Chinese medicine Wentong decoction (WTD) in EOS apoptosis in asthmatic rats. This work also explored the mechanism of WTD regulation in EOS apoptosis and provided a new target for clinical treatment of asthma. Read More

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April 2018
3 Reads

Techniques for extraction and isolation of natural products: a comprehensive review.

Chin Med 2018 17;13:20. Epub 2018 Apr 17.

2Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632 People's Republic of China.

Natural medicines were the only option for the prevention and treatment of human diseases for thousands of years. Natural products are important sources for drug development. The amounts of bioactive natural products in natural medicines are always fairly low. Read More

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HPLC-ICP-MS speciation analysis and risk assessment of arsenic in .

Chin Med 2018 16;13:19. Epub 2018 Apr 16.

National Institutes for Food and Drug Control, No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050 China.

Background: , one of the most valued traditional herbal medicines in China, contains high amount of arsenic. Considering the adverse health effects of arsenic, this is of particular concern. The aim of this study was to determine and analyze arsenic speciation in , and to measure the associated human health risks. Read More

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April 2018
1 Read

A concise classification of ().

Chin Med 2018 10;13:18. Epub 2018 Apr 10.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong China.

Books that record the sources and applications of medicinal materials are commonly known as () in China. () literature review is the very first step in the standard authentication procedure of Chinese medicinals. As an important part of China's cultural heritage, these various () texts represent centuries of accumulated wisdom in combating disease and preserving health. Read More

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April 2018
1 Read

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chin Med 2018 27;13:17. Epub 2018 Mar 27.

1Zhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Changjiang Road 80, Nanyang, 473004 Henan China.

Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. So far, no Western medicine treatment can completely inhibit or reverse the progress of SSc, while at the same time, our previous series of studies have shown that the treatment of SSc by the Wenyang Huazhuo Tongluo formula (WYHZTL), a Chinese herbal decoction, shows a delightful prospect. The aim of this study is to further investigate the mechanism of anti-fibrosis of WYHZTL formula in SSc mouse model. Read More

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March 2018
1 Read

Psoriasis therapy by Chinese medicine and modern agents.

Chin Med 2018 23;13:16. Epub 2018 Mar 23.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China.

Psoriasis is a chronic, painful, disfiguring and non-contagious skin disease that has globally affected at least 200 million patients. In general, mild to moderate psoriasis patients will be treated by chemical drugs or Chinese medicine, while targeting systemic biological drugs have been successfully developed with good efficacy but high cost burden to patients with severe psoriasis. Since the underlying mechanisms of psoriasis are not well understood, in this review, psoriasis pathogenesis and clinical therapeutic principles by modern medicine and Chinese medicine are extensively described. Read More

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March 2018
4 Reads

Approaches in studying the pharmacology of Chinese Medicine formulas: bottom-up, top-down-and meeting in the middle.

Chin Med 2018 21;13:15. Epub 2018 Mar 21.

1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China.

Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active compound(s) of CM formulas, which biological entities they target, and through which signaling pathway(s) they act to modify disease symptoms, are still difficult tasks for researchers, even when equipped with an arsenal of advanced modern technologies. Multiple approaches, including network pharmacology, pharmaco-genomics, -proteomics, and -metabolomics, have been developed to study the pharmacology of CM formulas. Read More

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March 2018
1 Read

Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2.

Chin Med 2018 20;13:14. Epub 2018 Mar 20.

1Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016 China.

Background: Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages in the brain may accelerate the progression of VD. Endocannabinoids are involved in neuronal protection against inflammation-induced neuronal injury. Read More

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March 2018
1 Read

Coptidis rhizoma and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity.

Chin Med 2018 7;13:13. Epub 2018 Mar 7.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, People's Republic of China.

Background: Coptidis rhizoma (CR) is the dried rhizome of Franch., C. Y. Read More

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March 2018
1 Read

Development of models for classification of action between heat-clearing herbs and blood-activating stasis-resolving herbs based on theory of traditional Chinese medicine.

Chin Med 2018 27;13:12. Epub 2018 Feb 27.

1School of Chines Materia Medica, Beijing University of Chinese Medicine, Yangguang South Avenue, Fangshan District, Beijing, 102488 China.

Background: Action ("" in Chinese) of traditional Chinese medicine (TCM) is the high recapitulation for therapeutic and health-preserving effects under the guidance of TCM theory. TCM-defined herbal properties ("" in Chinese) had been used in this research. TCM herbal property (TCM-HP) is the high generalization and summary for actions, both of which come from long-term effective clinical practice in two thousands of years in China. Read More

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February 2018
11 Reads

Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death.

Chin Med 2018 21;13:11. Epub 2018 Feb 21.

2Dermatological Department, First Affiliated Hospital of Wannan Medical College, Jinghu District, Wuhu, 241000 Anhui China.

Background: Melanoma is a leading cause of cancer death worldwide, and SMI-4a and G-Rh2 exert anti-tumor activity in multiple cancer. However, SMI-4a as well as a synergistic relationship between SMI-4a and G-Rh2 in anti-melanoma capacity are still unknown. Therefore, we investigated the effects of SMI-4a and combined SMI-4a with G-Rh2 on the viability, apoptosis and autophagy of melanoma, and to preliminarily explore the underlying mechanism of SMI-4a and combined SMI-4a with G-Rh2 in inhibiting tumor growth. Read More

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February 2018
1 Read

Complete chloroplast genome of the medicinal plant : gene organization, comparative analysis, and phylogenetic relationships within Zingiberales.

Chin Med 2018 13;13:10. Epub 2018 Feb 13.

1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dongcheng District, Dongzhimen Nanxiaojie within 16, Beijing, 100700 China.

Background: is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of is not clear yet, and the introduction of this plant has been hindered by many plant diseases. However, the correlational molecular studies are relatively scarce. Read More

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February 2018
3 Reads

Internationalization of traditional Chinese medicine: current international market, internationalization challenges and prospective suggestions.

Chin Med 2018 9;13. Epub 2018 Feb 9.

1International Research Center for Medicinal Administration, Peking University, Beijing, China.

Through reviewing the current international market for traditional Chinese medicine (TCM), this paper identified the internationalization challenges for TCM, including unclear therapeutic material basis and mechanism, difficulty of quality control, low preparation level, registration/policy barriers, and shortage of intellectual property. To deal with these challenges, suggestions were given including: (1) product innovation of TCM (study the TCM by using the methods and means of western medicine; innovate the basic theory of TCM; develop TCM health product); (2) standard innovation of TCM; (3) building big data platform of Chinese medicine (big data platform of TCM preparation; big data platform on the quality of TCM). Read More

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February 2018
1 Read

Authenticity analyses of Rhizoma Paridis using barcoding coupled with high resolution melting (Bar-HRM) analysis to control its quality for medicinal plant product.

Chin Med 2018 8;13. Epub 2018 Feb 8.

1College of Pharmaceutical Science, Hubei University of Chinese Medicine, Wuhan, 430065 China.

Background: Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Smith var. (Franch. Read More

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February 2018
1 Read

Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair.

Chin Med 2018 6;13. Epub 2018 Feb 6.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau SAR, China.

Background: Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug delivery vehicles. In the past few years, increasing studies have started to develop natural polysaccharides-based biomaterials for various applications in tissue engineering and regenerative medicine. Read More

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February 2018
1 Read

Shuganyin decoction improves the intestinal barrier function in a rat model of irritable bowel syndrome induced by water-avoidance stress.

Chin Med 2018 1;13. Epub 2018 Feb 1.

1Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032 China.

Background: To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress.

Methods: Forty male Wistar rats were divided into control, water-avoidance stress (WAS) group, WAS plus Shuganyin decoction (SGD) group and WAS plus dicetel (Dicetel) group. IBS was induced in rats by subjecting them to water-avoidance stress for 7 days. Read More

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February 2018
1 Read

SWOT analysis and revelation in traditional Chinese medicine internationalization.

Chin Med 2018 25;13. Epub 2018 Jan 25.

1China Pharmaceutical University, Longmian Road 639, Nanjing, 211198 China.

Traditional Chinese medicine (TCM) is currently the best-preserved and most influential traditional medical system with the largest number of users worldwide. In recent years, the trend of TCM adoption has increased greatly, but the process of TCM internationalization has suffered from a series of setbacks for both internal and external reasons. Thus, the process of TCM internationalization faces formidable challenges, although it also has favourable opportunities. Read More

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January 2018
9 Reads

Seeing the unseen of Chinese herbal medicine processing (): advances in new perspectives.

Chin Med 2018 17;13. Epub 2018 Jan 17.

3College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Liutai Avenue, Wenjiang District, Chengdu, Sichuan China.

Processing () represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) theory. Traditionally, most CHMs require a proper processing to meet the needs of specific clinical syndromes before being prescribed by TCM practitioners. During processing, significant changes in chemical profiles occur, which inevitably influence the associated pharmacological properties of a CHM. Read More

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January 2018
1 Read

Effects of Huang Bai () on bone growth and pubertal development in adolescent female rats.

Chin Med 2018 12;13. Epub 2018 Jan 12.

1Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447 Republic of Korea.

Background: To evaluate the effects of Huang Bai () on growth and maturation in adolescent female rats.

Methods: Female Sprague-Dawley rats (28 days old; n = 72) were divided into six daily treatment groups: control (distilled water), Huang Bai (100 and 300 mg/kg), recombinant human GH (rhGH; 20 μg/kg), estradiol (1 μg/kg), and triptorelin (100 μg). Body weight, food intake, and vaginal opening were measured daily from postnatal day (PND) 28 to PND 43. Read More

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January 2018
5 Reads

iTRAQ-based proteomic analysis to identify the molecular mechanism of Zhibai Dihuang Granule in the Yin-deficiency-heat syndrome rats.

Chin Med 2018 8;13. Epub 2018 Jan 8.

Institute of Cell Biology, Zhejiang University, Hangzhou, People's Republic of China.

Background: Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work has been conducted to explore the molecular mechanism of ZDG in YDH syndrome, and the processes of YDH syndrome prevention and treatment have been developed slowly. The present study was aimed to explore the therapeutic mechanism of ZDG on YDH syndrome. Read More

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January 2018
11 Reads

Different modulation of on the absorption profiling of triptolide and tripterine from in rat intestine.

Chin Med 2018 8;13. Epub 2018 Jan 8.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023 China.

Background: Compatibility with (PN) reduced the plasma concentration of triptolide and delayed the T of (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney.

Methods: The absorption of triptolide, triptonide, wilforlide and tripterine from monomer, TW, TW-PN, TW- (TW-CS) and Qing-Luo Tong-Bi were analyzed in duodenum, jejunum, ileum and colon of rat via single-pass intestinal perfusion model. An UPLC-MS/MS analysis method was developed to determine the concentration of triptolide, triptonide, wilforlide and tripterine in the inlet and outlet. Read More

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January 2018
6 Reads

Advances in bio-active constituents, pharmacology and clinical applications of rhubarb.

Chin Med 2017 28;12:36. Epub 2017 Dec 28.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023 Jiangsu China.

Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorous way. The main chemical compositions of rhubarb include anthraquinones, anthrones, stilbenes, tannins, polysaccharides etc. Read More

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December 2017
4 Reads

Metabolic regulations of a decoction of in acute liver injury of mouse models.

Chin Med 2017 20;12:35. Epub 2017 Dec 20.

Traditional Chinese Medicine Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630 China.

Background: Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether (HD) employs metabolic strategies against hepatitis is unknown.

Methods: We use the cytokines expression, levels of serum alanine transaminase and aspartate transaminase, survival and histological analysis to measure the effect of decoction of HD on acute severe hepatitis of mouse induced by LPS/GALN. Read More

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December 2017
5 Reads

Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics.

Chin Med 2017 8;12:34. Epub 2017 Dec 8.

Beijing Friendship Hospital Affiliated to Capital Medical University, No. 95, Yongan Road, Xuanwu District, Beijing, 100050 China.

Background: Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM samples, ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF/MS) combined with chemometrics (partial least squared discriminant analysis, PLS‑DA) method was applied in the present study.

Methods: The chromatography, chemical composition and MS information of RPM samples from 18 geographical origins were acquired and profiled by UPLC-QTOF/MS. Read More

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December 2017
7 Reads

Active fraction (HS7) from inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells.

Chin Med 2017 15;12:33. Epub 2017 Nov 15.

Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, 11696 Taiwan.

Background: The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets for therapeutic developments. In a relatively limited subset of NSCLC, these pathways driven by mutant EGFR can be treated by the tyrosine kinase inhibitors (TKIs)-mediated targeted therapy. Read More

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November 2017
5 Reads

Hepatoprotective properties of Pursh against carbon tetrachloride-induced acute liver injury in mice.

Chin Med 2017 30;12:32. Epub 2017 Oct 30.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Room 6034, Building N22, Avenida da Universidade, Macao, People's Republic of China.

Background: Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis. The aims of the present study were to evaluate the probable properties of the aqueous extract of PCP on carbon tetrachloride (CCl)-induced acute liver injury in mice.

Methods: C57BL/6 mice were orally administered an aqueous extract of PCP (5. Read More

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October 2017
6 Reads

Chemical characterization of wound ointment (WO) and its effects on fracture repair: a rabbit model.

Chin Med 2017 30;12:31. Epub 2017 Oct 30.

Department of Traumatic Orthopedics and Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Block B, No 10 Huadong Road, Nanning, 530011 Guangxi China.

Background: Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to explore the corresponding molecular mechanism in cytokine.

Methods: The qualitative and quantitative analysis of WO was conducted by liquid chromatography-mass spectrometry (LC-MS). Read More

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October 2017
4 Reads

Effects of pretreatment with methanol extract of Peucedani Radix on transient ischemic brain injury in mice.

Chin Med 2017 24;12:30. Epub 2017 Oct 24.

College of Korean Medicine, Dong-Eui University, Yangjeong-ro, Busanjin-gu, Busan, 47227 Republic of Korea.

Background: Stroke is the second most common cause of death and may result in various disabilities; thus, identification of neuroprotective therapeutic agents is important. Peucedani Radix (PR), the root of , is a well-known remedy for damp and phlegm in Korean medicine and has also been shown to exert antioxidant and anti-inflammatory activities. This study was performed to investigate the mechanism underlying the anti-inflammatory effect of methanol extract of PR (PRex) on cerebral ischemic injury. Read More

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October 2017
8 Reads

Effect of methanol extract of Salviae miltiorrhizae Radix in high-fat diet-induced hyperlipidemic mice.

Chin Med 2017 13;12:29. Epub 2017 Oct 13.

School of Korean Medicine, Yangsan Campus of Pusan National University, Yangsan-si, 50612 Republic of Korea.

Background: The dried root of , Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to have a bitter flavor, be slightly cold in nature, and exert therapeutic actions in the heart and liver meridians. Thus, SR has been used to control symptoms related to cardiovascular diseases. Read More

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October 2017
5 Reads

Ten years of exploration, a new journey to start: advancing to the next level.

Chin Med 2017 21;12:28. Epub 2017 Sep 21.

Editorial Office (Macau) of Chinese Medicine, International Society for Chinese Medicine, Macau, China.

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September 2017
5 Reads

Revealing topics and their evolution in biomedical literature using Bio-DTM: a case study of ginseng.

Chin Med 2017 12;12:27. Epub 2017 Sep 12.

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China.

Background: Valuable scientific results on biomedicine are very rich, but they are widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents without any prior annotations or labels. In this paper, taking ginseng as an example, biological dynamic topic model (Bio-DTM) was proposed to conduct a retrospective study and interpret the temporal evolution of the research of ginseng. Read More

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September 2017
4 Reads

Anti-tumor effects of the American cockroach, .

Chin Med 2017 12;12:26. Epub 2017 Sep 12.

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, 100029 China.

Since the incidence of cancer has been on the rise due to increasing exposure to various carcinogenic factors in recent years, cancer has gradually become the first killer to the health of human beings. A growing attention has been paid to anti-cancer effects of traditional Chinese medicine (TCM) with low toxicity and good efficacy. As a kind of TCM, () has a good effect on clinical application, and its anti-tumor effects has been increasingly well studied. Read More

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September 2017
8 Reads

Efficacy of Chinese herbal medicine for stroke modifiable risk factors: a systematic review.

Chin Med 2017 5;12:25. Epub 2017 Sep 5.

Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Ultimo, NSW Australia.

Background: The vast majority of stroke burden is attributable to its modifiable risk factors. This paper aimed to systematically summarise the evidence of Chinese herbal medicine (CHM) interventions on stroke modifiable risk factors for stroke prevention.

Methods: A literature search was conducted via the MEDLINE, CINAHL/EBSCO, SCOPUS, and Cochrane Database from 1996 to 2016. Read More

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September 2017
7 Reads

Danggui Buxue Tang, a simple Chinese formula containing Astragali Radix and Angelicae Sinensis Radix, stimulates the expressions of neurotrophic factors in cultured SH-SY5Y cells.

Chin Med 2017 22;12:24. Epub 2017 Aug 22.

Department of Biology, Hanshan Normal University, Chaozhou, 521041 Guangdong China.

Background: Danggui Buxue Tang (DBT), a phytoestrogen-enriched Chinese herbal formula, serves as dietary supplement in stimulating the "" functions of menopausal women. In traditional Chinese medicine (TCM) theory, has a strong relationship with brain activities. Previous studies supported that some ingredients of DBT possessed neuronal beneficial functions. Read More

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August 2017
3 Reads

A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders.

Chin Med 2017 21;12:23. Epub 2017 Aug 21.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing, 100700 China.

Background: QiXueHe Capsule (QXHC) is a Chinese patent drug that is extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated.

Methods: A list of QXHC putative targets were predicted using MetaDrug. Read More

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August 2017
24 Reads

Temporal divergence of changes in pain and pain-free grip strength after manual acupuncture or electroacupuncture: an experimental study in people with lateral epicondylalgia.

Chin Med 2017 4;12:22. Epub 2017 Aug 4.

Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute and Department of Physical Therapy, University of British Columbia, 2635 Laurel Street, Vancouver, BC V5Z3M9 Canada.

Background: The objective of this study was to examine, in individuals with lateral epicondylalgia (LE), the acute time course of acupuncture-induced hypoalgesia and change in pain-free grip strength (PFGS).

Methods: This was an experimental study, conducted at a single research center in Vancouver, BC. Twenty-one participants with unilateral LE lasting more than 6 weeks duration were enrolled. Read More

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August 2017
3 Reads

Cupping therapy versus acupuncture for pain-related conditions: a systematic review of randomized controlled trials and trial sequential analysis.

Chin Med 2017 24;12:21. Epub 2017 Jul 24.

Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing, 100029 China.

Background: Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two therapies.

Objectives: To compare the beneficial effectiveness and safety between cupping therapy and acupuncture for pain-related conditions to provide evidence for clinical practice. Read More

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July 2017
4 Reads

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine.

Chin Med 2017 12;12:20. Epub 2017 Jul 12.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, N22-7038, Avenida da Universidade, Taipa, Macao, 999078 China.

In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-clearing and detoxicating (HCD) herbs are essential components of TCM formulas for cancer treatment. An increasing interest has been focused on the study of HCD herbs and accumulated evidences have shown that HCD herbs or HCD herbs-based formulas exhibited remarkable anticancer effects when used alone or combined with other therapeutic approaches. Read More

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July 2017
3 Reads

A research on syndrome element differentiation based on phenomenology and mathematical method.

Chin Med 2017 10;12:19. Epub 2017 Jul 10.

Institute of Electrical Engineering, Yanshan University, No. 438, Hebei Avenue, Qinhuangdao, 066004 Hebei People's Republic of China.

Background: As an empirical medical system independent of conventional Western medicine (CWM), over thousands of years, traditional Chinese medicine (TCM) has established its own unique method of diagnosis and treatment. The perspective of holism and system in TCM is essentially different from the view of Reductionism in CWM. With the development of modern science and technology, the restriction of reductionism is more and more prominent, and researchers begin to pay more attention to holistic thinking in TCM. Read More

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July 2017
2 Reads

High-throughput sequencing technology reveals that continuous cropping of American ginseng results in changes in the microbial community in arable soil.

Chin Med 2017 3;12:18. Epub 2017 Jul 3.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 China.

Background: American ginseng ( L.) is renowned worldwide for its eutherapeutic effects. The replantation of American ginseng usually fails due to problems associated with continuous cropping. Read More

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July 2017
11 Reads

Relationship between Chinese medicine dietary patterns and the incidence of breast cancer in Chinese women in Hong Kong: a retrospective cross-sectional survey.

Chin Med 2017 29;12:17. Epub 2017 Jun 29.

School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.

Background: This retrospective cross-sectional study aimed to investigate the relationship between Chinese medicine (CM) dietary patterns (, , and ) and the incidence of breast cancer among Chinese women in Hong Kong.

Methods: Breast cancer cases (n = 202) and healthy controls (n = 202) were matched according to demographics. Chinese women residing in Hong Kong for the past 7 years were recruited by media advertisements (e. Read More

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June 2017
5 Reads

A simple method for HPLC retention time prediction: linear calibration using two reference substances.

Chin Med 2017 19;12:16. Epub 2017 Jun 19.

National Institutes for Food and Drug Control, No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050 People's Republic of China.

Background: Analysis of related substances in pharmaceutical chemicals and multi-components in traditional Chinese medicines needs bulk of reference substances to identify the chromatographic peaks accurately. But the reference substances are costly. Thus, the relative retention (RR) method has been widely adopted in pharmacopoeias and literatures for characterizing HPLC behaviors of those reference substances unavailable. Read More

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June 2017
3 Reads

Chemical constituents from a and their antioxidant and neuroprotective activities.

Chin Med 2017 24;12:15. Epub 2017 May 24.

Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826 Republic of Korea.

Background: A few bioactivities of constituents from , which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether quercetin (), benzoic acid () and their analogues (, - and ) from have the antioxidant and neuroprotective activities and also their underlying mechanism. Read More

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May 2017
10 Reads

Rapid identification of growth years and profiling of bioactive ingredients in var. mongholicus () roots from Hunyuan, Shanxi.

Chin Med 2017 19;12:14. Epub 2017 May 19.

School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230031 China.

Background: The content of medicinal bioactive constituents in is affected by plant age. In this study, we devised a quick and convenient method for determining the age of , which was cultivated in Hunyuan County (Shanxi Province).

Methods: 1, 2, 3, 4, 5, 8, 10 growth years had 38 samples, all samples were collected separately. Read More

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May 2017
14 Reads

Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice.

Chin Med 2017 19;12:13. Epub 2017 May 19.

Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, People's Republic of China.

Background: Jiangtang decoction (JTD) is a China patented drug which contains Willd, Bunge, Bunge, Bunge, and Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms. Read More

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May 2017
12 Reads