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    358 results match your criteria Chinese Medicine [Journal]

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    Complete chloroplast genome of the medicinal plant: gene organization, comparative analysis, and phylogenetic relationships within Zingiberales.
    Chin Med 2018 13;13:10. Epub 2018 Feb 13.
    1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dongcheng District, Dongzhimen Nanxiaojie within 16, Beijing, 100700 China.
    Background: is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position ofis not clear yet, and the introduction of this plant has been hindered by many plant diseases. However, the correlational molecular studies are relatively scarce. Read More

    Internationalization of traditional Chinese medicine: current international market, internationalization challenges and prospective suggestions.
    Chin Med 2018 9;13. Epub 2018 Feb 9.
    1International Research Center for Medicinal Administration, Peking University, Beijing, China.
    Through reviewing the current international market for traditional Chinese medicine (TCM), this paper identified the internationalization challenges for TCM, including unclear therapeutic material basis and mechanism, difficulty of quality control, low preparation level, registration/policy barriers, and shortage of intellectual property. To deal with these challenges, suggestions were given including: (1) product innovation of TCM (study the TCM by using the methods and means of western medicine; innovate the basic theory of TCM; develop TCM health product); (2) standard innovation of TCM; (3) building big data platform of Chinese medicine (big data platform of TCM preparation; big data platform on the quality of TCM). Read More

    Authenticity analyses of Rhizoma Paridis using barcoding coupled with high resolution melting (Bar-HRM) analysis to control its quality for medicinal plant product.
    Chin Med 2018 8;13. Epub 2018 Feb 8.
    1College of Pharmaceutical Science, Hubei University of Chinese Medicine, Wuhan, 430065 China.
    Background: Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine.Smith var.(Franch. Read More

    Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair.
    Chin Med 2018 6;13. Epub 2018 Feb 6.
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau SAR, China.
    Background: Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug delivery vehicles. In the past few years, increasing studies have started to develop natural polysaccharides-based biomaterials for various applications in tissue engineering and regenerative medicine. Read More

    Shuganyin decoction improves the intestinal barrier function in a rat model of irritable bowel syndrome induced by water-avoidance stress.
    Chin Med 2018 1;13. Epub 2018 Feb 1.
    1Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032 China.
    Background: To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress.

    Methods: Forty male Wistar rats were divided into control, water-avoidance stress (WAS) group, WAS plus Shuganyin decoction (SGD) group and WAS plus dicetel (Dicetel) group. IBS was induced in rats by subjecting them to water-avoidance stress for 7 days. Read More

    SWOT analysis and revelation in traditional Chinese medicine internationalization.
    Chin Med 2018 25;13. Epub 2018 Jan 25.
    1China Pharmaceutical University, Longmian Road 639, Nanjing, 211198 China.
    Traditional Chinese medicine (TCM) is currently the best-preserved and most influential traditional medical system with the largest number of users worldwide. In recent years, the trend of TCM adoption has increased greatly, but the process of TCM internationalization has suffered from a series of setbacks for both internal and external reasons. Thus, the process of TCM internationalization faces formidable challenges, although it also has favourable opportunities. Read More

    Seeing the unseen of Chinese herbal medicine processing (): advances in new perspectives.
    Chin Med 2018 17;13. Epub 2018 Jan 17.
    3College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Liutai Avenue, Wenjiang District, Chengdu, Sichuan China.
    Processing () represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) theory. Traditionally, most CHMs require a proper processing to meet the needs of specific clinical syndromes before being prescribed by TCM practitioners. During processing, significant changes in chemical profiles occur, which inevitably influence the associated pharmacological properties of a CHM. Read More

    Effects of Huang Bai () on bone growth and pubertal development in adolescent female rats.
    Chin Med 2018 12;13. Epub 2018 Jan 12.
    1Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447 Republic of Korea.
    Background: To evaluate the effects of Huang Bai () on growth and maturation in adolescent female rats.

    Methods: Female Sprague-Dawley rats (28 days old; n = 72) were divided into six daily treatment groups: control (distilled water), Huang Bai (100 and 300 mg/kg), recombinant human GH (rhGH; 20 μg/kg), estradiol (1 μg/kg), and triptorelin (100 μg). Body weight, food intake, and vaginal opening were measured daily from postnatal day (PND) 28 to PND 43. Read More

    iTRAQ-based proteomic analysis to identify the molecular mechanism of Zhibai Dihuang Granule in the Yin-deficiency-heat syndrome rats.
    Chin Med 2018 8;13. Epub 2018 Jan 8.
    Institute of Cell Biology, Zhejiang University, Hangzhou, People's Republic of China.
    Background: Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work has been conducted to explore the molecular mechanism of ZDG in YDH syndrome, and the processes of YDH syndrome prevention and treatment have been developed slowly. The present study was aimed to explore the therapeutic mechanism of ZDG on YDH syndrome. Read More

    Different modulation ofon the absorption profiling of triptolide and tripterine fromin rat intestine.
    Chin Med 2018 8;13. Epub 2018 Jan 8.
    Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023 China.
    Background: Compatibility with(PN) reduced the plasma concentration of triptolide and delayed the Tof(TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney.

    Methods: The absorption of triptolide, triptonide, wilforlide and tripterine from monomer, TW, TW-PN, TW-(TW-CS) and Qing-Luo Tong-Bi were analyzed in duodenum, jejunum, ileum and colon of rat via single-pass intestinal perfusion model. An UPLC-MS/MS analysis method was developed to determine the concentration of triptolide, triptonide, wilforlide and tripterine in the inlet and outlet. Read More

    Advances in bio-active constituents, pharmacology and clinical applications of rhubarb.
    Chin Med 2017 28;12:36. Epub 2017 Dec 28.
    Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023 Jiangsu China.
    Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorous way. The main chemical compositions of rhubarb include anthraquinones, anthrones, stilbenes, tannins, polysaccharides etc. Read More

    Metabolic regulations of a decoction ofin acute liver injury of mouse models.
    Chin Med 2017 20;12:35. Epub 2017 Dec 20.
    Traditional Chinese Medicine Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630 China.
    Background: Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether(HD) employs metabolic strategies against hepatitis is unknown.

    Methods: We use the cytokines expression, levels of serum alanine transaminase and aspartate transaminase, survival and histological analysis to measure the effect of decoction of HD on acute severe hepatitis of mouse induced by LPS/GALN. Read More

    Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics.
    Chin Med 2017 8;12:34. Epub 2017 Dec 8.
    Beijing Friendship Hospital Affiliated to Capital Medical University, No. 95, Yongan Road, Xuanwu District, Beijing, 100050 China.
    Background: Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM samples, ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF/MS) combined with chemometrics (partial least squared discriminant analysis, PLS‑DA) method was applied in the present study.

    Methods: The chromatography, chemical composition and MS information of RPM samples from 18 geographical origins were acquired and profiled by UPLC-QTOF/MS. Read More

    Active fraction (HS7) frominhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells.
    Chin Med 2017 15;12:33. Epub 2017 Nov 15.
    Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, 11696 Taiwan.
    Background: The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets for therapeutic developments. In a relatively limited subset of NSCLC, these pathways driven by mutant EGFR can be treated by the tyrosine kinase inhibitors (TKIs)-mediated targeted therapy. Read More

    Hepatoprotective properties ofPursh against carbon tetrachloride-induced acute liver injury in mice.
    Chin Med 2017 30;12:32. Epub 2017 Oct 30.
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Room 6034, Building N22, Avenida da Universidade, Macao, People's Republic of China.
    Background: Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis. The aims of the present study were to evaluate the probable properties of the aqueous extract of PCP on carbon tetrachloride (CCl)-induced acute liver injury in mice.

    Methods: C57BL/6 mice were orally administered an aqueous extract of PCP (5. Read More

    Chemical characterization of wound ointment (WO) and its effects on fracture repair: a rabbit model.
    Chin Med 2017 30;12:31. Epub 2017 Oct 30.
    Department of Traumatic Orthopedics and Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Block B, No 10 Huadong Road, Nanning, 530011 Guangxi China.
    Background: Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to explore the corresponding molecular mechanism in cytokine.

    Methods: The qualitative and quantitative analysis of WO was conducted by liquid chromatography-mass spectrometry (LC-MS). Read More

    Effects of pretreatment with methanol extract of Peucedani Radix on transient ischemic brain injury in mice.
    Chin Med 2017 24;12:30. Epub 2017 Oct 24.
    College of Korean Medicine, Dong-Eui University, Yangjeong-ro, Busanjin-gu, Busan, 47227 Republic of Korea.
    Background: Stroke is the second most common cause of death and may result in various disabilities; thus, identification of neuroprotective therapeutic agents is important. Peucedani Radix (PR), the root of, is a well-known remedy for damp and phlegm in Korean medicine and has also been shown to exert antioxidant and anti-inflammatory activities. This study was performed to investigate the mechanism underlying the anti-inflammatory effect of methanol extract of PR (PRex) on cerebral ischemic injury. Read More

    Effect of methanol extract of Salviae miltiorrhizae Radix in high-fat diet-induced hyperlipidemic mice.
    Chin Med 2017 13;12:29. Epub 2017 Oct 13.
    School of Korean Medicine, Yangsan Campus of Pusan National University, Yangsan-si, 50612 Republic of Korea.
    Background: The dried root of, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to have a bitter flavor, be slightly cold in nature, and exert therapeutic actions in the heart and liver meridians. Thus, SR has been used to control symptoms related to cardiovascular diseases. Read More

    Revealing topics and their evolution in biomedical literature using Bio-DTM: a case study of ginseng.
    Chin Med 2017 12;12:27. Epub 2017 Sep 12.
    Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China.
    Background: Valuable scientific results on biomedicine are very rich, but they are widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents without any prior annotations or labels. In this paper, taking ginseng as an example, biological dynamic topic model (Bio-DTM) was proposed to conduct a retrospective study and interpret the temporal evolution of the research of ginseng. Read More

    Anti-tumor effects of the American cockroach,.
    Chin Med 2017 12;12:26. Epub 2017 Sep 12.
    Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, 100029 China.
    Since the incidence of cancer has been on the rise due to increasing exposure to various carcinogenic factors in recent years, cancer has gradually become the first killer to the health of human beings. A growing attention has been paid to anti-cancer effects of traditional Chinese medicine (TCM) with low toxicity and good efficacy. As a kind of TCM,() has a good effect on clinical application, and its anti-tumor effects has been increasingly well studied. Read More

    Efficacy of Chinese herbal medicine for stroke modifiable risk factors: a systematic review.
    Chin Med 2017 5;12:25. Epub 2017 Sep 5.
    Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Ultimo, NSW Australia.
    Background: The vast majority of stroke burden is attributable to its modifiable risk factors. This paper aimed to systematically summarise the evidence of Chinese herbal medicine (CHM) interventions on stroke modifiable risk factors for stroke prevention.

    Methods: A literature search was conducted via the MEDLINE, CINAHL/EBSCO, SCOPUS, and Cochrane Database from 1996 to 2016. Read More

    Danggui Buxue Tang, a simple Chinese formula containing Astragali Radix and Angelicae Sinensis Radix, stimulates the expressions of neurotrophic factors in cultured SH-SY5Y cells.
    Chin Med 2017 22;12:24. Epub 2017 Aug 22.
    Department of Biology, Hanshan Normal University, Chaozhou, 521041 Guangdong China.
    Background: Danggui Buxue Tang (DBT), a phytoestrogen-enriched Chinese herbal formula, serves as dietary supplement in stimulating the "" functions of menopausal women. In traditional Chinese medicine (TCM) theory,has a strong relationship with brain activities. Previous studies supported that some ingredients of DBT possessed neuronal beneficial functions. Read More

    A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders.
    Chin Med 2017 21;12:23. Epub 2017 Aug 21.
    Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing, 100700 China.
    Background: QiXueHe Capsule (QXHC) is a Chinese patent drug that is extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated.

    Methods: A list of QXHC putative targets were predicted using MetaDrug. Read More

    Temporal divergence of changes in pain and pain-free grip strength after manual acupuncture or electroacupuncture: an experimental study in people with lateral epicondylalgia.
    Chin Med 2017 4;12:22. Epub 2017 Aug 4.
    Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute and Department of Physical Therapy, University of British Columbia, 2635 Laurel Street, Vancouver, BC V5Z3M9 Canada.
    Background: The objective of this study was to examine, in individuals with lateral epicondylalgia (LE), the acute time course of acupuncture-induced hypoalgesia and change in pain-free grip strength (PFGS).

    Methods: This was an experimental study, conducted at a single research center in Vancouver, BC. Twenty-one participants with unilateral LE lasting more than 6 weeks duration were enrolled. Read More

    Cupping therapy versus acupuncture for pain-related conditions: a systematic review of randomized controlled trials and trial sequential analysis.
    Chin Med 2017 24;12:21. Epub 2017 Jul 24.
    Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing, 100029 China.
    Background: Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two therapies.

    Objectives: To compare the beneficial effectiveness and safety between cupping therapy and acupuncture for pain-related conditions to provide evidence for clinical practice. Read More

    Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine.
    Chin Med 2017 12;12:20. Epub 2017 Jul 12.
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, N22-7038, Avenida da Universidade, Taipa, Macao, 999078 China.
    In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-clearing and detoxicating (HCD) herbs are essential components of TCM formulas for cancer treatment. An increasing interest has been focused on the study of HCD herbs and accumulated evidences have shown that HCD herbs or HCD herbs-based formulas exhibited remarkable anticancer effects when used alone or combined with other therapeutic approaches. Read More

    A research on syndrome element differentiation based on phenomenology and mathematical method.
    Chin Med 2017 10;12:19. Epub 2017 Jul 10.
    Institute of Electrical Engineering, Yanshan University, No. 438, Hebei Avenue, Qinhuangdao, 066004 Hebei People's Republic of China.
    Background: As an empirical medical system independent of conventional Western medicine (CWM), over thousands of years, traditional Chinese medicine (TCM) has established its own unique method of diagnosis and treatment. The perspective of holism and system in TCM is essentially different from the view of Reductionism in CWM. With the development of modern science and technology, the restriction of reductionism is more and more prominent, and researchers begin to pay more attention to holistic thinking in TCM. Read More

    High-throughput sequencing technology reveals that continuous cropping of American ginseng results in changes in the microbial community in arable soil.
    Chin Med 2017 3;12:18. Epub 2017 Jul 3.
    Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 China.
    Background: American ginseng (L.) is renowned worldwide for its eutherapeutic effects. The replantation of American ginseng usually fails due to problems associated with continuous cropping. Read More

    Relationship between Chinese medicine dietary patterns and the incidence of breast cancer in Chinese women in Hong Kong: a retrospective cross-sectional survey.
    Chin Med 2017 29;12:17. Epub 2017 Jun 29.
    School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
    Background: This retrospective cross-sectional study aimed to investigate the relationship between Chinese medicine (CM) dietary patterns (,, and) and the incidence of breast cancer among Chinese women in Hong Kong.

    Methods: Breast cancer cases (n = 202) and healthy controls (n = 202) were matched according to demographics. Chinese women residing in Hong Kong for the past 7 years were recruited by media advertisements (e. Read More

    A simple method for HPLC retention time prediction: linear calibration using two reference substances.
    Chin Med 2017 19;12:16. Epub 2017 Jun 19.
    National Institutes for Food and Drug Control, No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050 People's Republic of China.
    Background: Analysis of related substances in pharmaceutical chemicals and multi-components in traditional Chinese medicines needs bulk of reference substances to identify the chromatographic peaks accurately. But the reference substances are costly. Thus, the relative retention (RR) method has been widely adopted in pharmacopoeias and literatures for characterizing HPLC behaviors of those reference substances unavailable. Read More

    Chemical constituents from aand their antioxidant and neuroprotective activities.
    Chin Med 2017 24;12:15. Epub 2017 May 24.
    Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826 Republic of Korea.
    Background: A few bioactivities of constituents from, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents fromalthough the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether quercetin (), benzoic acid () and their analogues (,-and) fromhave the antioxidant and neuroprotective activities and also their underlying mechanism. Read More

    Rapid identification of growth years and profiling of bioactive ingredients invar. mongholicus () roots from Hunyuan, Shanxi.
    Chin Med 2017 19;12:14. Epub 2017 May 19.
    School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230031 China.
    Background: The content of medicinal bioactive constituents inis affected by plant age. In this study, we devised a quick and convenient method for determining the age of, which was cultivated in Hunyuan County (Shanxi Province).

    Methods: 1, 2, 3, 4, 5, 8, 10 growth yearshad 38 samples, all samples were collected separately. Read More

    Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice.
    Chin Med 2017 19;12:13. Epub 2017 May 19.
    Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, People's Republic of China.
    Background: Jiangtang decoction (JTD) is a China patented drug which containsWilld,Bunge,Bunge,Bunge, andFranch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms. Read More

    Metabolomics approach reveals annual metabolic variation in roots ofKuan based on gas chromatography-mass spectrum.
    Chin Med 2017 3;12:12. Epub 2017 May 3.
    College of Agronomy, Sichuan Agricultural University, Chengdu, 611130 People's Republic of China.
    Background: Herbal quality is strongly influenced by harvest time. It is therefore one of crucial factors that should be well respected by herbal producers when optimizing cultivation techniques, so that to obtain herbal products of high quality. In this work, we paid attention on one of common used Chinese herbals,Kuan. Read More

    Identification of anti-HBV activities inAndr. using GRP78 as a drug target on Herbochip.
    Chin Med 2017 24;12:11. Epub 2017 Apr 24.
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
    Background: Herbochiptechnology is a high throughput drug screening platform in a reverse screening manner, in which potential chemical leads in herbal extracts are immobilized and drug target proteins can be used as probes for screening process [BMC Complementary and Alternative Medicine (2015) 15:146]. While herbal medicines represent an ideal reservoir for drug screenings, here a molecular chaperone GRP78 is demonstrated to serve as a potential target for antiviral drug discovery.

    Methods: We cloned and expressed a truncated but fully functional form of human GRP78 (hGRP78) and used it as a probe for anti-HBV drug screening on herbochips. Read More

    Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure.
    Chin Med 2017 24;12:10. Epub 2017 Apr 24.
    Institute of Traditional Chinese Medicine, Suzhou Hospital Affiliated to Nanjing University of Chinese Medicine, No. 18 Yangsu Road, Gusu District, Suzhou, 215009 Jiangsu Province China.
    Background: Bushen Tianjing Recipe (BTR) is a traditional Chinese herbal medicine that has been prescribed for premature ovarian failure (POF) for decades in China. Nevertheless, little is known regarding its underlying molecular mechanism. In the present study, we investigated the effects of BTR in a tripterygium glycoside (TG)-induced-POF rat model. Read More

    () extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase.
    Chin Med 2017 11;12. Epub 2017 Apr 11.
    Department of Nutrition, I-Shou University, No.8, Yida Rd., Yanchao District, Kaohsiung City, 82445 Taiwan.
    Background: (GT) () is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the effect of GT ethanol extract (GTE) on T cell-mediated adaptive immunity.

    Methods: Human peripheral blood mononuclear cells (PBMCs) and Jurkat T cells were activated by phytohemagglutinin in the presence of various doses (3. Read More

    Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice.
    Chin Med 2017 27;12. Epub 2017 Mar 27.
    Center of Clinical Pharmacy Education, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, 920-1181 Japan.
    Background: The Kampo medicine bofutsushosan (BTS;;) has been used as an anti-obesity treatment in overweight patients. In this study, we assessed the underlying physiological changes induced by BTS in obese mice maintained on a high-fat diet.

    Methods: Male ICR mice were fed a 60% kcal fat diet for 5 weeks starting at 4 weeks of age and then fed the same diet with administration of water (control) or aqueous BTS extract (1. Read More

    The neuroprotective effects of---against embolic stroke in rats.
    Chin Med 2017 31;12. Epub 2017 Jan 31.
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
    Background: Combinations of the traditional Chinese and Western medicines have been used to treat numerous diseases throughout the world, and there is a growing body of evidence showing that some of the herbs used in traditional Chinese medicine elicit significant pharmacological effects. The aim of this study was to demonstrate the neuroprotective effects of---(TRCQT) in combination with aspirin following middle cerebral artery occlusion (MCAO)-induced embolic stroke in rats.

    Methods: A blood clot was embolized into the middle cerebral artery of rats to induce focal ischemic brain injury. Read More

    Chemical compositions, chromatographic fingerprints and antioxidant activities of Citri Exocarpium Rubrum ().
    Chin Med 2017 25;12. Epub 2017 Jan 25.
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, 40402 Taiwan.
    Background: Citri Exocarpium Rubrum (CER), which is known asin Chinese, is the dried exocarp ofBlanco and its cultivars (Fam. Rutaceae) and is currently used in Chinese medicine to protect the stomach and eliminateand phlegm. The main aim of this study was to develop a high-performance liquid chromatography ultraviolet mass spectrometry (HPLC-UV-MS) method for determining the chemical compositions and fingerprint of CER. Read More

    Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in participants undergoing vascular laparotomy under general anesthesia: a randomized controlled trial.
    Chin Med 2017 16;12. Epub 2017 Jan 16.
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Si-chuan University, Chengdu, Sichuan China.
    Background: Postoperative gastrointestinal dysfunction (PGD) is a common complication following laparotomy under general anesthesia (GA). Abdominal distension occurs in 8-28% of surgeries within 24 h postoperatively. The present study aimed to analyze the efficacy of electroacupuncture (EA) for the prevention of PGD by applying preoperative EA stimulation of PC6 (), ST36 (), and ST37 () bilaterally twice within 24 h prior to surgery, compared with no acupuncture treatment. Read More

    Quality control ofand() by HPLC using kukoamines as markers.
    Chin Med 2017 9;12. Epub 2017 Jan 9.
    Research Group for Bioactive Products, Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.
    Background: Lycii Cortex (LyC), composed ofandand having the Chinese name Digupi, is used to treat chronic diseases like cough, hypertension, and diabetes in Eastern Asia. However, chromatographic methods, such as TLC and HPLC, to determine the phytochemical composition of LyC have not been included in any official compendiums. This study aims to establish a validated HPLC method for quality control of LyC. Read More

    The influence of duodenally-delivered Shakuyakukanzoto () on duodenal peristalsis during endoscopic retrograde cholangiopancreatography: a randomised controlled trial.
    Chin Med 2017 9;12. Epub 2017 Jan 9.
    Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani 2630, Toyama City, Toyama 930-0194 Japan.
    Background: Anti-cholinergic agents may be used to inhibit duodenal peristalsis, but they may have adverse effects. Shakuyakukanzoto () has an anti-spasmodic effect and has been used before for oesophagogastroduodenoscopy and colonoscopy. This randomised clinical trial aimed to evaluate the inhibitory effect of Shakuyakukanzoto on duodenal peristalsis, and its usefulness when administered into the duodenum just before endoscopic retrograde cholangiopancreatography (ERCP). Read More

    An investigation of fungal contamination on the surface of medicinal herbs in China.
    Chin Med 2017 3;12. Epub 2017 Jan 3.
    Research Centre of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China.
    Background: The dried parts of medicinal herbs are susceptible to the infection of fungi during pre- or post-harvest procedure. This study aimed to investigate the presence of fungi and their metabolites mycotoxins on the surface of medicinal herbs collected from China.

    Methods: Forty-five retail samples of 15 different medicinal herbs were collected from 3 different regions in China. Read More

    Comparison of chemical profiles and effectiveness between Erxian decoction and mixtures of decoctions of its individual herbs: a novel approach for identification of the standard chemicals.
    Chin Med 2017 3;12. Epub 2017 Jan 3.
    School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR China.
    Background: Identification of bioactive standard chemicals is a major challenge in the study of the Chinese medicinal formula. In particular, the chemical components may interact differently depending on the preparative methods, therefore affecting the amounts of bioactive components and their pharmacological properties in the medicinal formula. With the use of Erxian decoction (EXD) as a study model-a  well-known Chinese medicinal formula for treating menopausal symptoms, a novel and rapid approach in seeking standard chemicals has been established by differentially comparing the HPLC profiles and the menopause-related biochemical parameters of combined decoction of EXD (EXD-C) and mixtures of the decoctions of its individual herbs (EXD-S). Read More

    Acupuncture as an intervention to reduce alcohol dependency: a systematic review and meta-analysis.
    Chin Med 2016 15;11:49. Epub 2016 Dec 15.
    Department of Health Sciences, University of York, York, UK.
    Background: Acupuncture has been widely used as a treatment for alcohol dependence. An updated and rigorously conducted systematic review is needed to establish the extent and quality of the evidence on the effectiveness of acupuncture as an intervention for reducing alcohol dependence. This review aimed to ascertain the effectiveness of acupuncture for reducing alcohol dependence as assessed by changes in either craving or withdrawal symptoms. Read More

    Rapid differentiation offrom the threespecies by UPLC-ESI-QTOF-MS/MS and chemometrics analysis.
    Chin Med 2016 15;11:48. Epub 2016 Dec 15.
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region People's Republic of China ; Research Center for Pharmacognosy, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
    Background: ,var.andare the three botanical sources of, which are often used indiscriminately in herbal products. The aim of this study was to develop a rapid and accurate analytical method to identify the three different botanical sources ofby combining UPLC-ESI-QTOF-MS with chemometrics analysis. Read More

    Ameliorating effect ofdecoction combined with Fructus) on menopausal sweating and serum hormone profiles in a rat model.
    Chin Med 2016 22;11:47. Epub 2016 Nov 22.
    School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong SAR.
    Background: Modified(MEXD), i.e.,decoction (EXD) with Fructus() added, has been used to alleviate menopausal symptoms. Read More

    Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.
    Chin Med 2016 15;11:46. Epub 2016 Nov 15.
    Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Malaysia.
    Background: Bromelain, which is a cysteine endopeptidase commonly found in pineapple stems, has been investigated as a potential anti-cancer agent for the treatment of breast cancer. However, information pertaining to the effects of combining bromelain with existing chemotherapeutic drugs remains scarce. This study aimed to investigate the possible synergistic cytotoxic effects of using bromelain in combination with cisplatin on MDA-MB-231 human breast cancer cells. Read More

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