421 results match your criteria Chinese Medicine [Journal]


Combination of 15 lipid metabolites and motilin to diagnose spleen-deficiency FD.

Chin Med 2019 15;14:16. Epub 2019 Apr 15.

1Department of Gastroenterology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1, Xiyuan Caochang, Beijing, 100091 China.

Background: This study aims to assess clinical characteristics in FD with spleen deficiency syndrome and metabolic perturbations involved in FD progress. We combined metabolic biomarkers and clinical features into a better prediction for FD with Spleen Deficiency syndrome.

Methods: A total of 276 people were recruited, including 215 FD patients and 61 healthy control group (HC). Read More

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http://dx.doi.org/10.1186/s13020-019-0238-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466668PMC

A pair of new enantiomers of xanthones from the stems and leaves of .

Chin Med 2019 29;14:14. Epub 2019 Mar 29.

1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning People's Republic of China.

Background: The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this family plants.

Methods: The structures of new compounds and were elucidated mainly through comprehensive NMR and MS spectroscopic data, and their absolute configurations were determined by the comparison of the experimental and calculated electronic circular dichroism. Read More

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http://dx.doi.org/10.1186/s13020-019-0235-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441139PMC
March 2019
1 Read

Fabrication of paper-based enzyme immobilized microarray by 3D-printing technique for screening α-glucosidase inhibitors in mulberry leaves and lotus leaves.

Chin Med 2019 29;14:13. Epub 2019 Mar 29.

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China.

Background: The discovery of bioactive compounds in traditional Chinese medicine (TCM) has become an important field in TCM modernization. Ligand fishing is a suitable method for discovery of bioactive compounds in complex mixtures such as TCM with high selectivity. Because of unique advantage of low cost and convenience, paper-based microdevices can be good carriers for enzyme immobilized ligand fishing. Read More

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http://dx.doi.org/10.1186/s13020-019-0236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440092PMC

Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology.

Chin Med 2019 27;14:12. Epub 2019 Mar 27.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China.

Background: Water extract (WAE) and ultrafine powder (UFP) are two types of commonly used supplements in preparing various pharmaceutical products and functional foods. However, the correlations of the chemical compositions with the traditional functions between WAE and the herb itself, as well as the potential problems of safety for UFP have been more and more concerned by many doctors and customers.

Methods: In this study, a new whole ingredients extract of Astragalus (WIE) was prepared using the gradient solvent extraction method. Read More

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http://dx.doi.org/10.1186/s13020-019-0234-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438022PMC
March 2019
1 Read

Developing natural products as potential anti-biofilm agents.

Chin Med 2019 20;14:11. Epub 2019 Mar 20.

2Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan People's Republic of China.

Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotics and antimicrobial agents. Quorum sensing (QS) is cell-to-cell communication mechanism, which plays an important role in biofilm development and balances the environment when the bacteria density becomes high. Read More

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http://dx.doi.org/10.1186/s13020-019-0232-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425673PMC
March 2019
1 Read

Identifying the functions and biomarkers of and aqueous extracts in hepatic cells.

Chin Med 2019 20;14:10. Epub 2019 Mar 20.

1Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 100 Taiwan.

Background: Homeostasis is a crucial concept used to describe the condition of patients and the roles of herbs in traditional Chinese medicine. Qi-deficiency pattern is one of the conditions when loss of homeostasis and is usually characterized by symptoms including lassitude, spontaneous sweating, and a weak pulse, which are not easy to quantitate. and were usually prescribed for carriers with hepatitis and patients with metastatic colon cancer, because these patients tended to experience fatigue. Read More

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http://dx.doi.org/10.1186/s13020-019-0233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425643PMC

Plastid genome and composition analysis of two medical ferns: Nakai and Thunb.

Chin Med 2019 14;14. Epub 2019 Mar 14.

2School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.

Background: Nakai and Thunb. are ferns that are popularly used for medicine, as recorded by the Chinese pharmacopoeia, and are distributed in different regions of China. However, is not record in the Standards of Chinese Herbal Medicines in Hong Kong. Read More

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http://dx.doi.org/10.1186/s13020-019-0230-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417082PMC
March 2019
2.343 Impact Factor

Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine.

Chin Med 2019 12;14. Epub 2019 Mar 12.

1Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 138, Xianlin Avenue, Qixia District, Nanjing, 210023 China.

Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides an opportunity to clarify the action mechanism of TCMs, TCM syndromes or after TCM treatment. This review aims to provide the metabolomics evidence available on TCM-based therapeutic measures against viral pneumonia. Read More

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http://dx.doi.org/10.1186/s13020-019-0229-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417174PMC
March 2019
1 Read

Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation.

Chin Med 2019 12;14. Epub 2019 Mar 12.

2Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000 Sichuan China.

Background: Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investigate whether SKN can sensitize the therapeutic effect of paclitaxel (PTX) in drug-resistant human ovarian carcinoma cells.

Methods: Human ovarian carcinoma A2780 cell along with the paired PTX-resistant A2780/PTX cells were used. Read More

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http://dx.doi.org/10.1186/s13020-019-0231-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417206PMC
March 2019
2.343 Impact Factor

Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis.

Chin Med 2019 1;14. Epub 2019 Mar 1.

1The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 China.

Background: Fuzi-Lizhong pill (FZLZP), which was first recorded in the Classic-"Taiping Huimin Heji Ju Fang" of the Song Dynasty, has been widely used to treat gastrointestinal disease in clinic for thousands of years in China. However, an in-depth understanding of the chemical constituents of FZLZP and its potential bioactive constituents is lacking.

Methods: A simple, sensitive and selective method of high-performance liquid chromatography coupled with quadrupole-time-of-flight high-definition mass spectrometry (HPLC-Q-TOF/MS) and automated data analysis (Agilent MassHunter Qualitative Analysis B. Read More

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http://dx.doi.org/10.1186/s13020-019-0227-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397459PMC
March 2019
4 Reads

High content screening for drug discovery from traditional Chinese medicine.

Chin Med 2019 28;14. Epub 2019 Feb 28.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.

Traditional Chinese medicine (TCM) represents the crystallization of Chinese wisdom and civilization. It has been valued as the renewable source for the discovery of novel drugs, owing to its long-term proved efficacy in human diseases and abundant biologically active components pools. To dissect the mystery of TCM, modern technologies such as omics approaches (proteomics, genomics, metabolomics) and drug screening technologies (high through-put screening, high content screening and virtual screening) have been widely applied to either identify the drug target of TCM or identify the active component with certain bio-activity. Read More

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http://dx.doi.org/10.1186/s13020-019-0228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394041PMC
February 2019
1 Read

A new GIS model for ecologically suitable distributions of medicinal plants.

Chin Med 2019 20;14. Epub 2019 Feb 20.

1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 China.

Background: The endangered rate of medicinal plant exceeds that of endangered plant species. However, blindly introducing medicinal plants in regions without comprehensively considering the involved environmental factors results in diseases and insect pests and the consequent overproof pesticide residue as well as reduces the quality of herbal medicine produced.

Methods: Global Medicinal Plant Geographic Information System (GMPGIS) was developed to analyze environmental information of ecologically suitable regions, thus guiding the conservation and introduction of medicinal plants. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-019-0226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383245PMC
February 2019
6 Reads

Baduanjin exerts anti-diabetic and anti-depression effects by regulating the expression of mRNA, lncRNA, and circRNA.

Chin Med 2019 1;14. Epub 2019 Feb 1.

1Diabetes Research Center, Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, 100029 China.

Background: Baduanjin, a traditional Chinese exercise therapy, has been widely used in China to treat type 2 diabetes (T2DM) with depression (DD). However, the underlying mechanism of Baduanjin in anti-DD is unclear. This study was focused on investigating the effects of Baduanjin on symptoms of depression and blood glucose in patients with DD and the underlying mechanism. Read More

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http://dx.doi.org/10.1186/s13020-019-0225-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359771PMC
February 2019
2.343 Impact Factor

Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway.

Chin Med 2019 29;14. Epub 2019 Jan 29.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao China.

Background: The combination of Radix Paeoniae Alba (RPA) and Rhizoma Atractylodis Macrocephalae (RAM) has long been used as a classic herb pair for the treatment of gynecologic and gastrointestinal diseases, but the underlying mechanisms of the herb pair remain unknown. This study aims to explore the anti-inflammatory potentials of RPA-RAM herb pair and to elucidate the underlying mechanisms.

Methods: The bioactive parts of RPA-RAM were extracted and screened through the inhibitory effects against nitric oxide (NO) production. Read More

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http://dx.doi.org/10.1186/s13020-019-0224-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352364PMC
January 2019
3 Reads
2.343 Impact Factor

Differential proteomics for studying action mechanisms of traditional Chinese medicines.

Chin Med 2019 8;14. Epub 2019 Jan 8.

2Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang People's Republic of China.

Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes their functions. In this paper, the applications of differential proteomics in exploring the action mechanisms of TCMs on various diseases including cancers, cardiovascular diseases, diabetes, liver diseases, kidney disorders and obesity, etc. were reviewed. Read More

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http://dx.doi.org/10.1186/s13020-018-0223-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325846PMC
January 2019
1 Read

Systems biology approaches in the study of Chinese herbal formulae.

Chin Med 2018 29;13:65. Epub 2018 Dec 29.

Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China.

Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biological system and their interactions under specific conditions. The core of systems biology is holistic and systematic research, which is different from the manner of thinking and research of all other branches of biology to date. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0221-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311004PMC
December 2018
10 Reads

An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model.

Chin Med 2018 22;13:64. Epub 2018 Dec 22.

Institute of Chinese Medicine, E205, Science Centre East Block, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Background: The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. However, most of these herbal formulae/products lack of evidence-based efficacy. Read More

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http://dx.doi.org/10.1186/s13020-018-0222-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303939PMC
December 2018
3 Reads

Gut microbiota was modulated by moxibustion stimulation in rats with irritable bowel syndrome.

Chin Med 2018 18;13:63. Epub 2018 Dec 18.

3Yueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China.

Background: The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of moxibustion in IBS treatment remains unknown.

Methods: An IBS rat model was established by colorectal distention (CRD) stimulus and mustard oil clyster. Read More

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http://dx.doi.org/10.1186/s13020-018-0220-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299671PMC
December 2018
2 Reads

Cardiac function evaluation for a novel one-step detoxification product of .

Chin Med 2018 17;13:62. Epub 2018 Dec 17.

4China Military Institute of Chinese Medicine, 302 Military Hospital, No. 100 Xisihuan, Beijing, 100039 People's Republic of China.

Background: has been used as the first cardiac drug over a 1000 years in Asian countries. Although most detoxification products are confirmed to be safe, the effect is not potent as desired. In previous study, we designed a one-step detoxification product by fresh cutting and continuously dried, which preserved more water-soluble alkaloids while eliminating toxicity. Read More

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http://dx.doi.org/10.1186/s13020-018-0219-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297959PMC
December 2018
4 Reads

Metabonomic study of the protective effect of Fukeqianjin formula on multi-pathogen induced pelvic inflammatory disease in rats.

Chin Med 2018 10;13:61. Epub 2018 Dec 10.

1School of Medicine, Chengdu University, No. 2025, Cheng Luo Road, Chengdu, 610106 Sichuan People's Republic of China.

Background: Fukeqianjin formula has been effectively used in the treatment of pelvic inflammatory disease (PID) and the related complications in clinic. Although there have been some studies about the underlying mechanism that focus on its anti-inflammatory and immunoregulatory activities. But the mechanism is still not fully understood. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
Publisher Site
http://dx.doi.org/10.1186/s13020-018-0217-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288860PMC
December 2018
21 Reads
2.343 Impact Factor

Application of metabolomics in toxicity evaluation of traditional Chinese medicines.

Chin Med 2018 4;13:60. Epub 2018 Dec 4.

3State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009 China.

Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an "omics" approach that aims to comprehensively analyze all metabolites in biological samples. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0218-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278008PMC
December 2018
3 Reads

Pharmacological effects of medicinal components of (Thunb.) DC.

Chin Med 2018 27;13:59. Epub 2018 Nov 27.

1Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Thunb. DC. (AL) has a long history as one of the important herbs used in East Asia. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
Publisher Site
http://dx.doi.org/10.1186/s13020-018-0216-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260578PMC
November 2018
15 Reads

Predicting the potential global distribution of diosgenin-contained species.

Chin Med 2018 19;13:58. Epub 2018 Nov 19.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 China.

Background: Diosgenin, mainly extracted from wild diosgenin-contained species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological damage, wild species resources available have been gradually declining. Therefore, identification of new potential ecological distribution of diosgenin-contained species is necessary for diosgenin production. Read More

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http://dx.doi.org/10.1186/s13020-018-0215-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245757PMC
November 2018
10 Reads

A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide.

Chin Med 2018 16;13:57. Epub 2018 Nov 16.

3Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 151 Malianwa North Road, Haidian District, Beijing, 100193 People's Republic of China.

Modern studies have shown that adaptogens can non-specifically enhance the resistance of human body under a wide range of external stress conditions with a multi-targeted and multi-channel network-like manner, especially by affect the immune-neuro-endocrine system and the hypothalamic-pituitary-adrenal axis. This review article draws the attention to the relationships of adaptogens, tonics from traditional Chinese medicine (TCM) and ginseng-like herbs worldwide, which all have similar plant sources and clinical applications. To clarify the sources and pharmacological mechanisms of these plant-originated adaptogens, which will provide useful information for the utilization of adaptogens to improve the human health. Read More

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http://dx.doi.org/10.1186/s13020-018-0214-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240259PMC
November 2018
1 Read
2.343 Impact Factor

Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis.

Chin Med 2018 26;13:54. Epub 2018 Oct 26.

2School of Traditional Chinese Materia Medica, Shanxi University of Chinese Medicine, No. 121, Daxue Street, Taiyuan, 030619 Shanxi China.

Background: Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been reported, such as enhanced anti-ovarian cancer, antioxidative activity, and neuroprotective effects. Ge-Gen-Qin-Lian decoction (GQD), a classic TCM formula, has been used to treat type 2 diabetes mellitus in China. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0208-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204051PMC
October 2018
2 Reads
2.343 Impact Factor

Blood and urinary metabolomic evidence validating traditional Chinese medicine diagnostic classification of major depressive disorder.

Chin Med 2018 25;13:53. Epub 2018 Oct 25.

4School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.

Background: Major depressive disorder (MDD) is a highly heterogeneous disease. Further classification may characterize its heterogeneity. The purpose of this study was to examine whether metabolomic variables could differentiate traditional Chinese medicine (TCM) diagnostic subtypes of MDD. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0211-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203264PMC
October 2018
5 Reads

The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups.

Chin Med 2018 19;13:51. Epub 2018 Oct 19.

1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047 Jiangxi China.

Background: Compounds with the ability to scavenge reactive oxygen species (ROS) and inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases. The number and location of phenolic hydroxyl of the flavonoids will significantly influence the inhibition of tyrosinase activity. Phenolic hydroxyl is indispensable to the antioxidant activity of flavonoids. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0206-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194685PMC
October 2018
5 Reads

Indigenous medicinal plants of Pakistan used to treat skin diseases: a review.

Chin Med 2018 19;13:52. Epub 2018 Oct 19.

4Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethno-pharmacological Relevance: Plants are providing reliable therapy since time immemorial. Pakistan has a great diversity in medicinal flora and people use these ethno-medicines to deal with many skin problems. This review explores the fundamental knowledge on various dermatological properties of medicinal plants of Pakistan and is aimed to provide a baseline for the discovery of new plants having activities against skin issues. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0210-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194552PMC
October 2018
18 Reads

Internationalization of Traditional/Complementary Medicine products: market entry as medicine.

Chin Med 2018 11;13:50. Epub 2018 Oct 11.

1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao.

Internationalization of Traditional/Complementary Medicine (T&CM) products is important for initiating and sustaining developments in this field. Particularly for traditional Chinese medicines (TCMs), the global market continues to expand due to an interest in the potential clinical benefits of traditional approaches that are largely considered lower risk and lower cost than many conventional treatments. While the benefits of internationalization hold clear advantages for the business of T&CM products, keeping abreast of regulatory processes in different countries and regions that regularly revise market entry requirements is challenging. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0209-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182808PMC
October 2018
16 Reads

Rapid screening and identification of bioactive compounds specifically binding to beta 2-adrenoceptor from San-ao decoction using affinity magnetic fine particles coupled with high-performance liquid chromatography-mass spectrometry.

Chin Med 2018 24;13:49. Epub 2018 Sep 24.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069 China.

Background: San-ao decoction (SAD) has been widely used in Chinese medicine against respiratory diseases, such as asthma and rhinallergosis. The bioactive compounds for such pharmacological action remain unknown.

Methods: We developed a methodology to isolate the bioactive compounds of SAD. Read More

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http://dx.doi.org/10.1186/s13020-018-0207-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154427PMC
September 2018
4 Reads
2.343 Impact Factor

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence.

Chin Med 2018 18;13:48. Epub 2018 Sep 18.

4Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous plant resources to cure various respiratory disorders. The primary objective of this review was to assemble all available ethno-medicinal data of plants used for respiratory disorders in Pakistan. Read More

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http://dx.doi.org/10.1186/s13020-018-0204-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145130PMC
September 2018
9 Reads

Characterization and anti-tumor activity of a polysaccharide isolated from grown in the Huoshan County.

Chin Med 2018 10;13:47. Epub 2018 Sep 10.

1School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013 Jiangsu China.

Background: Polysaccharides are carbohydrate chains composed of linked monosaccharide units. Accumulating studies report that polysaccharides isolated from have a variety of functions. However, the composition and anti-tumor activity of grown in the Huoshan area are largely unknown. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0205-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131812PMC
September 2018
13 Reads

A network pharmacology approach to explore the mechanisms of Erxian decoction in polycystic ovary syndrome.

Chin Med 2018 29;13:46. Epub 2018 Aug 29.

Liaoning Provincial Key Laboratory of Follicle Development and Reproductive Health (Office of Science and Technology), Jinzhou, China.

Background: Polycystic ovary syndrome (PCOS) significantly affects women's health and well-being. To explore the pharmacological basis of the Erxian decoction (EXD) action in PCOS therapy, a network interaction analysis was conducted at the molecular level.

Methods: The active elements of EXD were identified according to the oral bioavailability and drug-likeness filters from three databases: traditional Chinese medicine system pharmacology analysis platform, TCM@taiwan and TCMID, and their potential targets were also identified. Read More

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http://dx.doi.org/10.1186/s13020-018-0201-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114271PMC
August 2018
15 Reads

Wnt5a mediates the effects of Bushen Huoxue decoction on the migration of bone marrow mesenchymal stem cells in vitro.

Chin Med 2018 29;13:45. Epub 2018 Aug 29.

1Department of Traumatology, The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 22 Jiangnan-Xi Road, Guangzhou, 510240 Guangdong People's Republic of China.

Background: Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway.

Methods: BHD was extracted by petroleum, and its composition was analysed. Read More

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http://dx.doi.org/10.1186/s13020-018-0200-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114862PMC
August 2018
45 Reads

Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells.

Chin Med 2018 29;13:44. Epub 2018 Aug 29.

1Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong China.

Background: Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese medicine may shed light on design of new therapeutic modes to overcome chemo-resistance. Read More

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http://dx.doi.org/10.1186/s13020-018-0203-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114245PMC
August 2018
1 Read

Application of delayed luminescence method on measuring of the processing of Chinese herbal materials.

Chin Med 2018 25;13:43. Epub 2018 Aug 25.

1Leiden University European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

Background: Based on the principle of tradition Chinese medicine, the processing refers to various techniques that alter the overall properties of herbal materials to meet the requirements of therapeutic applications. However, the standards of quality control and scientific standard operation protocol for processing manufacturing are largely unknown and there is a huge demand for the development of scientific tools for evaluating the quality during and after the processing. The key challenge in evidence-based medicine is to characterize the processing of herbal materials from system-based perspective. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0202-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109338PMC
August 2018
18 Reads

Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice.

Chin Med 2018 20;13:42. Epub 2018 Aug 20.

1Department of Microbiology and Immunology, School of Basic Medical Sciences, Jinan University, Guangzhou, 510632 Guangdong China.

Background: Influenza virus is a single-stranded RNA virus that causes influenza in humans and animals. About 600 million people around the world suffer from influenza every year. Upon recognizing viral RNA molecules, TLR7 (Toll-like receptor) initiates corresponding immune responses. Read More

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http://dx.doi.org/10.1186/s13020-018-0199-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102858PMC
August 2018
2 Reads

Diversity and composition of bacterial endophytes among plant parts of .

Chin Med 2018 14;13:41. Epub 2018 Aug 14.

1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 China.

Background: Bacterial endophytes are widespread inhabitants inside plant tissues that play crucial roles in plant growth and biotransformation. This study aimed to offer information for the exploitation of endophytes by analyzing the bacterial endophytes in different parts of .

Methods: We used high-throughput sequencing methods to analyze the diversity and composition of bacterial endophytes from different parts of . Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0198-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092820PMC
August 2018
28 Reads

Bioaccessibility and risk assessment of heavy metals, and analysis of arsenic speciation in .

Chin Med 2018 31;13:40. Epub 2018 Jul 31.

1National Resource Center for Chinese Materia Medica, State Key Laboratory Breeding Base of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing, 100700 People's Republic of China.

Background: () is a famous and precious Traditional Chinese Medicine (TCM), while frequent reports of heavy metals, especially arsenic, exceeding standards in in recent years have raised concerns of its safety. Therefore, it is urgent for a research on heavy metals (Cu, Pb, As, Cd, Hg) in , of its bioaccessibility, dietary exposure estimation, arsenic speciation analysis and health risks assessment to human body.

Methods: Three 30 g batches of mixed wild growth samples were collected from Qinghai Province and each batch were divided into three parts: the whole , the stroma and the caterpillar body. Read More

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http://dx.doi.org/10.1186/s13020-018-0196-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069848PMC
July 2018
10 Reads

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders.

Chin Med 2018 18;13:39. Epub 2018 Jul 18.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.

Background: Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurvedic supplements and is believed to have a beneficial effect on the entire gastrointestinal (GI) tract.

Purpose: We aim to summarize available literature focused on the components of TLP (, and ) and discusse their effectiveness and therapeutic value for improving lower GI symptoms in functional GI disorders, particularly irritable bowel syndrome (IBS). Read More

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http://dx.doi.org/10.1186/s13020-018-0197-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052535PMC
July 2018
3 Reads

Effect of Da-Cheng-Qi decoction for treatment of acute kidney injury in rats with severe acute pancreatitis.

Chin Med 2018 13;13:38. Epub 2018 Jul 13.

Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan People's Republic of China.

Background: The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including those of the liver and lungs. However, the pharmacological effects in the kidney, a target organ, are still unclear. Read More

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http://dx.doi.org/10.1186/s13020-018-0195-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045888PMC
July 2018
10 Reads

Makino inhibits PamCSK-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation.

Chin Med 2018 5;13:37. Epub 2018 Jul 5.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China.

Background: Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory effects of SP were associated with the toll-like receptors (TLRs)-mediated nuclear factor-κB (NF-κB) and the mitogen-activated protein kinase (MAPK) signaling pathways.

Methods: Raw 264. Read More

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http://dx.doi.org/10.1186/s13020-018-0193-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034227PMC
July 2018
16 Reads

Combination of and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β.

Chin Med 2018 4;13:36. Epub 2018 Jul 4.

1Department of Respiratory Medicine II, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan China.

Background: Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side effects. Recently, combination of two Chinese herbal medicine preparations, and ligustrazine (SML), serves as an alternative medicine for treatment of IPF in clinical practices in China. Read More

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http://dx.doi.org/10.1186/s13020-018-0194-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032559PMC
July 2018
7 Reads

Anticancer drug discovery from Chinese medicinal herbs.

Chin Med 2018 4;13:35. Epub 2018 Jul 4.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 7014, N22, Avenida da Universidade, Taipa, Macao China.

Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as targeted therapy and immunotherapy. Chinese medicinal herbs have attracted considerable attention due to their potential anticancer effects. Read More

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https://cmjournal.biomedcentral.com/articles/10.1186/s13020-
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http://dx.doi.org/10.1186/s13020-018-0192-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031194PMC
July 2018
13 Reads

a review of chemical constituents and pharmacological activities.

Chin Med 2018 25;13:34. Epub 2018 Jun 25.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Room 7015, N22, Avenida da Universidade, Taipa, Macau SAR People's Republic of China.

Sieb. et Zucc. is part of the genus of the family . Read More

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http://dx.doi.org/10.1186/s13020-018-0191-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020197PMC
June 2018
6 Reads

Global ecological regionalization of 15 species: nature sources of shikimic acid.

Chin Med 2018 15;13:31. Epub 2018 Jun 15.

2Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 China.

Background: plants are relevant officinal and ornamental species that are native in Eastern Asia, and they are the main sources of shikimic acid. Shikimic acid is an important component of Tamiflu, which is recognized for its ability to resist avian influenza by the World Health Organization. To determine areas where 15 species can be grown and to understand the importance of species diversity, we should enhance the prediction of suitable areas. Read More

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http://dx.doi.org/10.1186/s13020-018-0186-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003141PMC
June 2018
12 Reads

The therapeutic effect of scalp acupuncture on natal autism and regressive autism.

Chin Med 2018 15;13:30. Epub 2018 Jun 15.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

Background: Autism spectrum disorders (ASD) is a common disease and the incidence has been rising constantly. Acupuncture is one of the most widely used complementary and alternative medicine therapies. Despite studies had been done on the effectiveness of acupuncture on ASD children, how factors such as chronological age and the onset pattern influence the effectiveness of the therapy remains unclear. Read More

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http://dx.doi.org/10.1186/s13020-018-0189-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003091PMC
June 2018
10 Reads

In silico approach in reveal traditional medicine plants pharmacological material basis.

Chin Med 2018 19;13:33. Epub 2018 Jun 19.

3Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 151 Malianwa North Road, Haidian District, Beijing, 100193 People's Republic of China.

In recent years, studies of traditional medicinal plants have gradually increased worldwide because the natural sources and variety of such plants allow them to complement modern pharmacological approaches. As computer technology has developed, in silico approaches such as virtual screening and network analysis have been widely utilized in efforts to elucidate the pharmacological basis of the functions of traditional medicinal plants. In the process of new drug discovery, the application of virtual screening and network pharmacology can enrich active compounds among the candidates and adequately indicate the mechanism of action of medicinal plants, reducing the cost and increasing the efficiency of the whole procedure. Read More

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http://dx.doi.org/10.1186/s13020-018-0190-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006786PMC
June 2018
9 Reads

Effective authentication of Placenta Hominis.

Chin Med 2018 18;13:32. Epub 2018 Jun 18.

Li Dak Sum Yip Yio Chin R & D Centre for Chinese Medicine, State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) and School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

Background: Human placenta is used to make the medicinal product Placenta Hominis in Asian countries. With its therapeutic benefits and limited supply, intentional or inadvertent adulteration is found in the market. In order to enforce the implementation of product description laws and protect customer rights, we established a hierarchical protocol involving morphological, chemical, biochemical and molecular diagnosis to authenticate this medicinal product. Read More

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http://dx.doi.org/10.1186/s13020-018-0188-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007028PMC
June 2018
2 Reads

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in mice.

Chin Med 2018 14;13:29. Epub 2018 Jun 14.

1School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR People's Republic of China.

Background: To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl) in mice.

Methods: Fifty male Balb-c mice (4-month-old) were randomly divided into five groups: control, AlCl plus vehicle, AlCl plus IRN (20 mg/kg), AlCl plus IRN (40 mg/kg) and AlCl plus donepezil (5 mg/kg). Learning and memory impairments were induced in mice by subcutaneously injecting with AlCl (50 mg/kg) once a day for 8 consecutive weeks. Read More

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http://dx.doi.org/10.1186/s13020-018-0187-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000983PMC
June 2018
11 Reads