724,351 results match your criteria Chinese Medicine [Journal]


Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos.

Chemosphere 2018 Dec 8;219:557-566. Epub 2018 Dec 8.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China; Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China. Electronic address:

α-Bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is a common ingredient in many pharmaceuticals and personal care products (PPCPs). Despite being widely used, little is known about its toxic effects on organisms and aquatic environment. In this study, we investigated the developmental toxicity of α-Bisabolol, especially its effects on the cardiac development using zebrafish embryos as a model. Read More

View Article
December 2018

Effects of biochar on growth, and heavy metals accumulation of moso bamboo (Phyllostachy pubescens), soil physical properties, and heavy metals solubility in soil.

Chemosphere 2018 Nov 26;219:510-516. Epub 2018 Nov 26.

State Key Laboratory of Subtropical Silviculture, Key Laboratory of Soil Contamination Bioremediation of Zhejiang Province, Zhejiang A & F University, Hangzhou, Zhejiang, 311300, PR China.

Pot experiment was conducted to investigate the effects of wood biochar (5%), bamboo biochar (5%), rice straw biochar (5%) and Chinese walnut shell biochar (5%) on growth, accumulation of heavy metals in moso bamboo, soil physical properties, and solubility of heavy metals in soil. The results revealed that dry weight of moso bamboo was significantly increased in treatments of wood biochar (5%), rice straw biochar (5%) and Chinese walnut shell biochar (5%) except bamboo biochar (5%). Application of straw biochar (5%) was most effective in enhancing plants biomass, with increase of 157%, 113% and 111% in leaves, roots and stems of moso bamboo. Read More

View Article
November 2018

Salvanic acid B inhibits myocardial fibrosis through regulating TGF-β1/Smad signaling pathway.

Biomed Pharmacother 2018 Dec 12;110:685-691. Epub 2018 Dec 12.

Department of Cardiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China. Electronic address:

Objective: Salvanic Acid B (Sal B) was proved to show significant effect against fibrosis and myocardial injury. This study aimed to investigate the protective effects and the mechanisms of Sal B on myocardial fibrosis.

Methods: The mice were randomly assigned to five groups: control group, model group, positive group, low-dose group, high-dose group. Read More

View Article
December 2018
1 Read

Therapeutic evaluation of acupoint stimulation with needle-scapelon on rat model of degenerative cervical intervertebral discs.

Biomed Pharmacother 2018 Dec 12;110:677-684. Epub 2018 Dec 12.

Department of Acupuncture, Qianfo Shan Hospital, Jinan, Shandong Province, 250014, China.

Cervical spondylosis (CS), which is resulted from degeneration of cervical intervertebral disc, is a common disease seriously threatening human health and quality of life. However, there is still no effective clinic strategies for the treatment of this disease. The acupoint stimulation with needle-scalpel is a widely used approach to treat orthopedic diseases. Read More

View Article
December 2018

Relationship between anxiety, depression, sex, obesity, and internet addiction in Chinese adolescents: A short-term longitudinal study.

Addict Behav 2018 Dec 7;90:421-427. Epub 2018 Dec 7.

Research Institute on Addictions, University at Buffalo, State University of New York, Buffalo, NY, United States. Electronic address:

Associations between anxiety, depression and adolescent Internet addiction have been well documented in the literature; however, few published studies have examined these relationships considering the developmental trajectory courses of adolescent Internet addiction as well as the individual differences over time. Using a sample of 1545 Chinese adolescents and 3 waves of data over six months, we examined the longitudinal associations between anxiety and depression and Internet addiction, considering sex and obesity. We used latent growth curve modeling (LGCM) to examine the overall conditions of Internet addiction, and latent class growth modeling (LCGM) to determine adolescent developmental membership for Internet addiction. Read More

View Article
December 2018

Overexpression of maize MYB-IF35 increases chilling tolerance in Arabidopsis.

Authors:
Chen Meng Na Sui

Plant Physiol Biochem 2018 Dec 7;135:167-173. Epub 2018 Dec 7.

Shandong Provincial Key Laboratory of Plant Stress, College of Life Sciences, Shandong Normal University, Jinan, 250014, China. Electronic address:

Chilling stress is a critical environmental factor that limits plant growth, yield and distribution. Maize (Zea mays L.) is an important food and forage crop, and industrial raw material, in China. Read More

View Article
December 2018
1 Read

Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction: Promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response.

Biomed Pharmacother 2018 Dec 12;111:19-30. Epub 2018 Dec 12.

The Third Affiliate Hospital of Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

Bone marrow mesenchymal stem cells (BM-MSCs) are recruited to injured site for cardiac self-repairing in acute myocardial infarction (AMI), but the spontaneous mobilization of BM-MSCs is insufficient for self-repairing. Inflammation initiated by necrosis cardiomyocytes induced cardiac remodeling and depression. Given the anti-inflammatory effects of BM-MSCs and the inextricably relationship among inflammation, ventricular remodeling and depression following AMI, methods focused on enhancing BM-MSCs mobilization are promising. Read More

View Article
December 2018

Study on anti-hyperuricemia effects and active ingredients of traditional Tibetan medicine TongFengTangSan (TFTS) by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

J Pharm Biomed Anal 2018 Nov 17;165:213-223. Epub 2018 Nov 17.

Jiangxi University of Traditional Chinese Medicine, No. 1688 Meiling Road, Nanchang, 330004, PR China. Electronic address:

TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Read More

View Article
November 2018

How does self-esteem affect mobile phone addiction? The mediating role of social anxiety and interpersonal sensitivity.

Psychiatry Res 2018 Dec 6;271:526-531. Epub 2018 Dec 6.

College of Humanities, Hubei University of Chinese Medicine, China.

Low self-esteem is an important factor influencing mobile phone addiction, which has been well documented. However, little research focused on the mechanism underlying the association between self-esteem and mobile phone addiction. We hypothesized that social anxiety and interpersonal sensitivity may mediate the relationship between self-esteem and mobile phone addiction. Read More

View Article
December 2018

Performance and microbial community of an electric biological integration reactor (EBIR) for treatment of wastewater containing ibuprofen.

Bioresour Technol 2018 Dec 7;274:447-458. Epub 2018 Dec 7.

School of Civil Engineering and Architecture, University of Jinan, Jinan 250022, China; School of Civil Engineering and Architecture, Qilu Institute of Technology, Jinan 250022, China.

Electric biological integration reactor (EBIR) was designed and built for the treatment of wastewater containing ibuprofen. This study evaluates the removal performance of EBIR by comparison with biological aerated filter (BAF), while also discussing the optimal operational parameters of EBIR within the context of the response surface methodology. The results indicate that EBIR exhibits higher average removal rates of ibuprofen, chemical oxygen demand (COD) and NH-N, i. Read More

View Article
December 2018

Maternal childhood emotional abuse predicts Chinese infant behavior problems: Examining mediating and moderating processes.

Child Abuse Negl 2018 Dec 12;88:307-316. Epub 2018 Dec 12.

Beijing Key Laboratory of Learning and Cognition, Research Center for Child Development, School of Psychology, Capital Normal University, China.

The current study examined the mediating effect of maternal negative expressiveness as well as the moderating effects of infant inhibitory control (IC) in the association between maternal childhood emotional abuse (CEA) and infant behavior problems. Drawing from 207 families from mainland China, 2-wave data were reported in this study when the infants were 6 months (T1) and 14 (T2) months. Mothers (Mean age = 32. Read More

View Article
December 2018

Cortisol stress reactivity moderates the effects of parental corporal punishment on Chinese preschoolers' executive function.

Child Abuse Negl 2018 Dec 12;88:288-297. Epub 2018 Dec 12.

Research Center for Child Development, College of Elementary Education, Capital Normal University, No.105 Xisan Huan Beilu, Beijing, 100048, China. Electronic address:

Background: To date whether the effects of parental corporal punishment (CP) on executive function (EF) distinct components are different is less clear. Moreover, theory and empirical work suggest that physiological regulation system may help to explain the individual differences in the developmental outcomes associated with parental CP.

Objective: This study examined the effects of parental CP on Chinese preschoolers' EF and whether the cortisol stress reactivity would moderate such effects. Read More

View Article
December 2018

Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset.

Infect Genet Evol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China.

Several genome-wide association studies (GWAS) identified new single nucleotide polymorphisms (SNPs) with susceptibility to Tuberculosis (TB). However, many of them were not replicated across ethnic groups. The cause of this phenomenon of genetic heterogeneity is uncertain. Read More

View Article
December 2018

Enhancement of the apparent solubility and bioavailability of Tadalafil nanoparticles via antisolvent precipitation.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address:

The ability to increase the bioavailability and dissolution of poorly soluble hydrophobic drugs has been a major challenge for pharmaceutical development. This study shows that the dissolution rate, apparent solubility and oral bioavailability of tadalafil (Td) can be improved by nano-sized amorphous particles prepared by using antisolvent precipitation. Acetone and an acetone-water solution (v:v, 9:1) were selected as solvents, with deionized water as the antisolvent. Read More

View Article
December 2018
1 Read

Anti-inflammatory action of HO-1/CO in human bronchial epithelium in response to cationic polypeptide challenge.

Mol Immunol 2018 Dec 12;105:205-212. Epub 2018 Dec 12.

School of Biomedical Sciences, The Chinese University of Hong Kong, China. Electronic address:

Carbon monoxide (CO) is an anti-inflammatory gaseous molecule produced endogenously by heme oxygenases (HOs) HO-1 and HO-2. However, the mechanisms underlying the anti-inflammatory effects of CO in the human bronchial epithelium are still not fully understood. In this study, the cationic peptide poly-l-arginine (PLA) was utilized to induce bronchial epithelial damage and subsequent pro-inflammatory cytokine release in the human bronchial epithelial cell line 16HBE14o-. Read More

View Article
December 2018

Alpha-synuclein is highly prone to distribution in the hippocampus and midbrain in tree shrews, and its fibrils seed Lewy body-like pathology in primary neurons.

Exp Gerontol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China; Medical Primate Research Center & Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100005, China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Diseases, Kunming 650118, China. Electronic address:

The Chinese tree shrew (TS) has many unique advantages that make it suitable for use as an experimental animal model for human disease including moderate body size, low cost of feeding, short reproductive cycle and lifespan, and close phylogenetic relationship to primates. Our previous studies have shown that TS treated with the mitochondrial inhibitor MPTP displayed classic Parkinsonian symptoms. Additionally, the structure of TS alpha-synuclein (α-syn) is highly homologous to that found in humans. Read More

View Article
December 2018

The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli.

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences (CAAS), 518 Ziyue Road, Shanghai, 200241, PR China. Electronic address:

Avian pathogenic Escherichia coli (APEC) causes severe respiratory and systemic diseases in poultry. The wzy gene encodes the O-antigen polymerase (Wzy), which plays an important role in the synthesis of the lipopolysaccharide (LPS) of bacteria. However, the function of the wzy gene in APEC remains unclear. Read More

View Article
December 2018

Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Oncological Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China. Electronic address:

Ethnopharmacological Relevance: The development of a multidrug-resistant (MDR) phenotype is a main obstacle to the successful treatment of breast cancer. Saponins of several herbs are considered as promising candidates for drug resistance treatment. We extracted Paris saponin VII (PS VII) from Trillium tschonoskii Maxim. Read More

View Article
December 2018
1 Read

Identification of a novel mutation in FBN1 in a Chinese family with inherited ectopia lentis by targeted NGS.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Aier School of Ophthalmology, Central South University, Tianxin District, Changsha, Hunan Province 410015, China; WuhanAier Eye Hospital, Aier Eye Hospital Group, Wuchuan District, Wuhan, Hubei Province 430063, China. Electronic address:

Aims: To diagnose a Chinese family with inherited ectopia lentis in a genetic method and analyze the genotype-phenotype correlation.

Methods: The phenotype of each family member was identified by detailed clinical examination. We used targeted next generation sequencing (NGS) to identify mutations in FBN1 in an efficient and accurate way. Read More

View Article
December 2018

The clinicopathologic impacts and prognostic significance of GLUT1 expression in patients with lung cancer: A meta-analysis.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Department of Thoracic Oncology, First Affiliated Hospital of Xi'an Medical College, Xi'an 710032, Shaanxi Province, PR China. Electronic address:

Background: Accumulating studies have reported that GLUT1 is aberrantly expressed in lung cancer; nevertheless, the clinicopathologic significance and the prognostic role of GLUT1 still remain controversial. The aim of this meta-analysis was to identify the clinicopathologic and prognostic implications of the GLUT1 expression in lung cancer patients.

Materials And Methods: Databases with literature published in English, including Cochrane Library, Embase, Web of Science, and PubMed, and the China National Knowledge Infrastructure (CNKI) and WanFang database in Chinese were searched comprehensively for relevant studies in August 2017. Read More

View Article
December 2018

Different species or genetically divergent populations? Integrative species delimitation of the Primulina hochiensis complex from isolated karst habitats.

Mol Phylogenet Evol 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address:

To consistently and objectively delineate species-level divergence from population subdivision has been a challenge in systematics. This is particularly evident in naturally fragmented and allopatric systems in which small population size often leads to extreme population structuring. Here we evaluated the robustness of the species delimitation methods implemented in BEAST, BPP, and iBPP in the Primulina hochiensis complex comprising four described and one candidate species (five taxa in total) distributed in karst landscapes of southern China. Read More

View Article
December 2018

Underestimated ecosystem carbon turnover time and sequestration under the steady state assumption: a perspective from long-term data assimilation.

Glob Chang Biol 2018 Dec 15. Epub 2018 Dec 15.

Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, China.

It is critical to accurately estimate carbon (C) turnover time as it dominates the uncertainty in ecosystem C sinks and their response to future climate change. In the absence of direct observations of ecosystem C losses, C turnover times are commonly estimated under the steady-state assumption (SSA), which has been applied across a large range of temporal and spatial scales including many at which the validity of the assumption is likely to be violated. However the errors associated with improperly applying SSA to estimate C turnover time and its covariance with climate as well as ecosystem C sequestrations have yet to be fully quantified. Read More

View Article
December 2018
1 Read

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.

Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.

Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. Read More

View Article
December 2018

SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPKα/mTOR Axis.

Hepatology 2018 Dec 15. Epub 2018 Dec 15.

Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, Berkeley, California, USA.

Sirtuin 4 (SIRT4) has been reported to play a vital role in the maintenance of glutamine catabolism and ATP homeostasis, but its character in hepatocellular carcinomas (HCCs) remains obscure. In this study, we observed low expression of SIRT4 in both HCC cell lines and HCCs from patients. Decreased disease-free survival time is associated with low tumor levels of SIRT4 in patients. Read More

View Article
December 2018

Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

College of Chinese Medicinal Materials, Jilin Agriculture University, Changchun, China.

Background: In China, Acanthopanax sessiliflorus is a delicious wild vegetable. It is also used to treat of inflammation and pain. Considering that chiisanoside (CSS) is the main constituent of the leaf of A. Read More

View Article
December 2018

Impact of cell culture media additives on IgG glycosylation produced in CHO cells.

Biotechnol Bioeng 2018 Dec 15. Epub 2018 Dec 15.

Merck Life Sciences, Upstream R&D, Frankfurter Strasse 250, Darmstadt, Germany.

Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of recombinant monoclonal antibodies produced in Chinese hamster ovary cells. Compounds were supplemented into the cell culture feed of fed-batch experiments performed with a CHO K1 and a CHO DG44 cell line expressing a recombinant IgG1. Read More

View Article
December 2018

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

View Article
December 2018

PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Macrophages polarization plays essential but different roles in most diseases such as atherosclerosis, adipose tissue inflammation, and insulin resistance. Our previous study revealed that protease-activated receptor 2 (PAR2), a G-protein coupled receptor influenced macrophage function, but little is known regarding the regulation of macrophage polarization process and its potential mechanisms. In the present study, bone marrow-derived macrophages (BMDM) isolated from C57/BL6 mice and cultured with L929-conditional medium and murine macrophage cell line RAW264. Read More

View Article
December 2018
1 Read

CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

Cancer stem cells (CSCs) exist in colon cancer and exhibit characteristics of stem cells which are due to lineages of tissues where they arise. Epithelial to mesenchymal transition (EMT)-undergoing cancer cells display CSC properties and therapeutic resistance. Cancer and stromal cells comprise of a tumor microenvironment. Read More

View Article
December 2018

BRD4 interacts with PML/RARα in acute promyelocytic leukemia.

Front Med 2018 Dec 14;12(6):726-734. Epub 2018 Dec 14.

State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Bromodomain-containing 4 (BRD4) has been considered as an important requirement for disease maintenance and an attractive therapeutic target for cancer therapy. This protein can be targeted by JQ1, a selective small-molecule inhibitor. However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), and whether BRD4 had interaction with promyelocytic leukemia-retinoic acid receptor α (PML/RARα) fusion protein to some extent. Read More

View Article
December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

View Article
December 2018
1 Read

Effective mucosal live attenuated Salmonella vaccine by deleting phosphotransferase system component genes ptsI and crr.

J Microbiol 2018 Oct 2. Epub 2018 Oct 2.

Radiation Biotechnology Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.

Salmonella enterica is a major human pathogen that causes invasive non-typhoidal Salmonellosis (iNTS), resulting in significant morbidity and mortality. Although a number of pre-clinical and clinical studies have reported on the feasibility of developing a safe and effective vaccine against iNTS, there have been no licensed Salmonella vaccines available to protect against NTS strains. Vaccine formulations of highest priority for NTS are live attenuated vaccines, which can elicit effective induction of intestinal mucosal and intracellular bacteria-specific cell mediated immune responses. Read More

View Article
October 2018
1 Read

Adsorption Study of Acid Soluble Lignin Removal from Sugarcane Bagasse Hydrolysate by a Self-Synthesized Resin for Lipid Production.

Appl Biochem Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, No.2 Nengyuan Road, Tianhe District, Guangzhou, 510640, People's Republic of China.

An adsorption resin CX-6 was synthesized and used for acid soluble lignin (ASL) removal from sugarcane bagasse hydrolysate (SCBH). The adsorption conditions of pH value, amount of adsorbent, initial ASL concentration, and temperature on ASL adsorption were discussed. The results showed the adsorption capacity of ASL was negatively affected by increasing temperature, solution pH, and adsorbent dose, and was positively affected by increasing initial concentration. Read More

View Article
December 2018

FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.

Immunol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.

Fc receptor common γ signaling chain (FcRγ), a common subunit shared by Fc receptors (FcγRI, III, IV, FcαRI, and FcεRI), is an important immune regulator both in innate and adaptive immunity. Previous studies have shown that FcRγ was a potential target of inflammatory diseases, whereas the role of FcRγ in sepsis has been poorly understood. In this study, we found that deficiency of FcRγ resulted in increased survival in lipopolysaccharide (LPS)/D-galactosamine and E. Read More

View Article
December 2018

The impact of public transportation on carbon emissions: a panel quantile analysis based on Chinese provincial data.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

Business School, Hunan University, Yuelu South Road, Changsha, 410082, Hunan Province, People's Republic of China.

Although the Chinese government emphasizes the significance of public transportation development and encourages green travel, no empirical study has examined whether the expansion of public transportation facilitates the mitigation of carbon emissions. To this end, we employ a panel quantile regression to test the endogenous relationship between public transportation scale and carbon emissions. The results suggest that the effect of public transportation scale on carbon emissions is heterogeneous across China's provinces based on the level of carbon emissions. Read More

View Article
December 2018

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 130021, China.

Homeostasis imbalance of selenium (Se) in diabetes has received great attention. This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG (n = 12), IGT (n = 15), T1D (n = 25), T2D (n = 137), and healthy controls (n = 50) were enrolled in the First Hospital of Jilin University. Read More

View Article
December 2018

Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms.

Metab Brain Dis 2018 Dec 14. Epub 2018 Dec 14.

Institute of Brain Science, Shanxi Datong University, Datong, China.

Multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and other neurodegenerative diseases of central nervous system (CNS) disorders are serious human health problems. Rho-kinase (ROCK) is emerging as a potentially important therapeutic target relevant to inflammatory neurodegeneration diseases. This is supported by studies showing the beneficial effects of fasudil, a ROCK inhibitor, in inflammatory neurodegeneration diseases. Read More

View Article
December 2018

Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide.

Mikrochim Acta 2018 Dec 14;186(1):20. Epub 2018 Dec 14.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

A self-sacrificing catalytic method is described for the preparation of magnetic core/dual-functional-shell nanocomposites composed of magnetite, gold and Prussian Blue (type FeO@Au-PB). Two reaction pathways are integrated. The first involves chemical dissolution of FeO (the self-sacrificing step) by acid to release ferrous ions which then reacts with hexacyanoferrate(IV) to generate PB in the proximity of the magntic nanoparticles (MNPs). Read More

View Article
December 2018

Recent Advances on Relationship Between Inorganic Phosphate and Pathologic Calcification: Is Calcification After Breast Augmentation with Fat Grafting Correlated with Locally Increased Concentration of Inorganic Phosphate?

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, China.

Background: Pathologic calcification has frequently occurred after breast augmentation with fat grafting as well as other conditions such as breast cancer, trauma, myocardial infarction, arteriosclerosis and even after reduction mammoplasty. Inorganic phosphate, correlated with fat metabolism, is an important factor that induces pathologic calcification such as vascular calcification.

Methods: A literature search was conducted using PubMed with the keywords: calcification, inorganic phosphate, fat. Read More

View Article
December 2018

M1/M2 Macrophages Play Different Roles in Adipogenic Differentiation of PDGFRα Preadipocytes In Vitro.

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Breast Plastic and Reconstructive Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, People's Republic of China.

Background: PGGFRα preadipocytes are the major subpopulations that can regenerate into adipocytes. Two different types of macrophages exist in the fat tissue: the classically activated macrophage (M1) and the alternatively activated macrophage (M2). In this study, we investigated whether M1/M2 macrophages play distinct roles in adipogenic differentiation of PDGFRα preadipocytes. Read More

View Article
December 2018

Adsorptive Removal of Tetracyclines and Fluoroquinolones Using Yak Dung Biochar.

Bull Environ Contam Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, 810008, Qinghai, China.

This study investigated the adsorptive removal of target fluoroquinolones and tetracyclines by biochar made by yak dung collected from the Qinghai-Tibet Plateau. Yak dung biochar pyrolyzed at 700 °C possessed surface area of 198.745 m g and multiple functional groups. Read More

View Article
December 2018

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides.

Sci Rep 2018 Dec 14;8(1):17850. Epub 2018 Dec 14.

Traditional Chinese Medicine College, Jilin Agricultural University, Changchun City, Jilin Province, 130118, China.

Asarum spp. are important medicinal plants that have the potential for use in treating various types of fevers. Aristolochic acid is one of the main toxic compounds present in these plants. Read More

View Article
December 2018
1 Read

Winged forelimbs of the small theropod dinosaur Caudipteryx could have generated small aerodynamic forces during rapid terrestrial locomotion.

Sci Rep 2018 Dec 14;8(1):17854. Epub 2018 Dec 14.

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, 100044, P. R. China.

Pennaceous feathers capable of forming aerodynamic surfaces are characteristic of Pennaraptora, the group comprising birds and their closest relatives among non-avian dinosaurs. However, members of the basal pennaraptoran lineage Oviraptorosauria were clearly flightless, and the function of pennaceous feathers on the forelimb in oviraptorosaurs is still uncertain. In the basal oviraptorosaur Caudipteryx both the skeleton and the plumage, which includes pennaceous feathers forming wing-like arrangements on the forelimbs, are well known. Read More

View Article
December 2018

Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates.

Sci Rep 2018 Dec 14;8(1):17868. Epub 2018 Dec 14.

Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine, Taipei Medical University, Taipei, Taiwan.

The sensitivity of traditional enzyme-linked immunosorbent assays (ELISAs) is limited by the low binding avidity and heterogeneous orientation of capture antibodies coated on polystyrene-based microplates. Here, we developed a highly sensitive ELISA strategy by fixing poly-protein G-expressing cells on microplates to improve the coating amount and displayed orientation of capture antibodies. One or eight repeated fragment crystallisable (Fc) binding domains of protein G are stably expressed on the surface of BALB/c 3T3 cells (termed 1pG cells or 8pG cells), which then act as highly antibody-trapping microparticles. Read More

View Article
December 2018

Fine mapping and discovery of candidate genes for seed size in watermelon by genome survey sequencing.

Sci Rep 2018 Dec 14;8(1):17843. Epub 2018 Dec 14.

Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, The Laboratory of Melon Crops, Zhengzhou, Henan Province, 450009, China.

Fine mapping and discovery of candidate genes underlying seed size are important for modern watermelon breeding. Here, by using a high-resolution genetic map and whole-genome genetic variation detection aided by genome survey sequencing, we fine mapped and discovered candidate genes for seed size in watermelon. QTL (quantitative trait locus) mapping identified two pleiotropic QTLs for seed size, namely, qSS4 and qSS6, using a high-density genetic map constructed by specific length amplified fragment sequencing. Read More

View Article
December 2018

Identification of cytochrome P450 monooxygenase genes and their expression in response to high temperature in the alligatorweed flea beetle Agasicles hygrophila (Coleoptera: Chrysomelidae).

Sci Rep 2018 Dec 14;8(1):17847. Epub 2018 Dec 14.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Cytochrome P450 monooxygenases (P450s) are a large class of enzymes that play essential roles in metabolic processes such as hormone synthesis and the catabolism of toxins and other chemicals in insects. In the present study, we identified 82 P450 genes using comprehensive RNA sequencing in the flea beetle Agasicles hygrophila, and all of the sequences were validated by cloning and sequencing. Phylogenetic analysis showed that the P450 genes in A. Read More

View Article
December 2018

Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure.

Nat Commun 2018 Dec 14;9(1):5326. Epub 2018 Dec 14.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, People's Republic of China.

Alphaviruses are enveloped RNA viruses that contain several human pathogens. Due to intrinsic heterogeneity of alphavirus particles, a high resolution structure of the virion is currently lacking. Here we provide a 3. Read More

View Article
December 2018

Overall water splitting by graphdiyne-exfoliated and -sandwiched layered double-hydroxide nanosheet arrays.

Nat Commun 2018 Dec 14;9(1):5309. Epub 2018 Dec 14.

Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

It is of great urgency to develop efficient, cost-effective, stable and industrially applicable electrocatalysts for renewable energy systems. But there are still few candidate materials. Here we show a bifunctional electrocatalyst, comprising graphdiyne-exfoliated and -sandwiched iron/cobalt layered double-hydroxide nanosheet arrays grown on nickel foam, for the oxygen and hydrogen evolution reactions. Read More

View Article
December 2018

Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese.

J Lipid Res 2018 Dec 14. Epub 2018 Dec 14.

Chinese Academy of Sciences, China;

Effects of PUFAs on metabolic syndrome (MetS) remain to be characterized, particularly in Asians. We aimed to investigate the prospective associations of PUFAs with MetS and the role of acylcarnitines in these associations in Chinese. Among 1,245 Chinese aged 50-70 who completed a 6-yr follow-up, baseline erythrocyte FAs and plasma acylcarnitines were profiled using gas chromatography coupled with positive chemical ionization and liquid chromatography-tandem mass spectrometry, respectively. Read More

View Article
December 2018

Role of diffusional kurtosis imaging in grading of brain gliomas: a protocol for systematic review and meta-analysis.

BMJ Open 2018 Dec 14;8(12):e025123. Epub 2018 Dec 14.

Lysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery UCL Hospitals NHS Trust, London, UK.

Introduction: Central nervous system (CNS) gliomas are the most common primary intra-axial brain tumours and pose variable treatment response according to their grade, therefore, precise staging is mandatory. Histopathological analysis of surgical tumour samples is still deemed as the state-of-the-art staging technique for gliomas due to the moderate specificity of the available non-invasive imaging modalities. A recently evolved analysis of the tissue water diffusion properties, known as diffusional kurtosis imaging (DKI), is a dimensionless metric, which quantifies water molecules' degree of non-Gaussian diffusion, hence reflects tissue microenvironment's complexity by means of non-invasive diffusion-weighted MRI acquisitions. Read More

View Article
December 2018
  • Page 1 of 14488