724,407 results match your criteria Chinese Medical Journal [Journal]


Matrine Suppresses Pancreatic Fibrosis by Regulating TGF-β/Smad Signaling in Rats.

Yonsei Med J 2019 Jan;60(1):79-87

Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Purpose: This study aimed to elucidate the molecular mechanisms of the anti-pancreatic fibrosis effects of matrine in rats.

Materials And Methods: Trinitrobenzene sulfonic acid was administrated to rats to establish a pancreatic fibrosis model. Rats were divided into four groups: Control, Sham, Model, and Matrine (n=8). Read More

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January 2019

Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy.

Yonsei Med J 2019 Jan;60(1):30-37

Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer (BC) patients undergoing epirubicin/cyclophosphamide-docetaxel (EC-D) adjuvant chemotherapy.

Materials And Methods: 427 BC patients who had underwent surgery were consecutively enrolled in this prospective cohort study. All patients were scheduled to receive EC-D adjuvant chemotherapy regimen, and they were divided into UGT2B7 -161 CC (n=141), UGT2B7 -161 CT (n=196), and UGT2B7 -161 TT (n=90) groups according to their genotypes. Read More

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January 2019

Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa).

Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan, 611130, China.

Elizabethkingia miricola is a Gram-negative rod which has been incriminated in severe infections in humans. Recently, a serious infectious disease was identified in Chinese spiny frogs (Quasipaa spinosa), in the Sichuan Province of China; the disease was characterized by corneal opacity, the presence of ascites, and neurologic symptoms. A Gram-negative bacillus was isolated from the liver, spleen, and kidney of the diseased frogs. Read More

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December 2018

Serum adipocyte fatty acid-binding protein levels: an indicator of non-alcoholic fatty liver disease in Chinese individuals.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.

Background & Aims: Serum adipocyte fatty acid-binding protein (A-FABP) is closely correlated to metabolic disorders such as obesity and insulin resistance (IR). Non-alcoholic fatty liver disease (NAFLD) is a typical feature of IR in the liver. The aim of this study was to explore the relationship between serum A-FABP levels and NAFLD. Read More

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December 2018

A Survey on the Prevalence and Risk Indicators of Erosive Tooth Wear among Adolescents in Guangzhou, South China.

J Oral Rehabil 2018 Dec 16. Epub 2018 Dec 16.

Southern Medical University, Savaid Medical School, University of the Chinese Academy of Sciences.

Background: Erosive tooth wear (ETW) has become a crucial oral health problem over the decades in China.

Objectives: To explore the prevalence and risk indicators of ETW among adolescents in Guangzhou, south China.

Methods: A cross-sectional survey of 720 participants was conducted in Guangzhou, using an equal-sized, stratified, multistage random sampling approach. Read More

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December 2018

Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line.

Cell Mol Neurobiol 2018 Dec 15. Epub 2018 Dec 15.

State Key Laboratory Cultivation Base For TCM Quality and Efficacy, School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.

Retinoic acid-induced 14 is a developmentally regulated gene induced by retinoic acid and is closely associated with NIK/NF-κB signaling. In the present study, we examined the effect of RAI14 on mTOR-mediated glial inflammation in response to inflammatory factors and chemical ischemia. A U87 cell model of LPS- and TNF-α-induced inflammation was used to investigate the role of RAI14 in glial inflammation. Read More

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December 2018

The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Shanghai Taiyin Biotech Co., Ltd., Shanghai, 201203, China.

Hyperosmolality has been commonly investigated due to its effects on the production and quality characteristics of monoclonal antibodies (mAbs) produced in CHO cell fed-batch cultures. However, the application of hyperosmolality at different times and its effect on biopotency have seldom been researched, especially in perfusion culture. In our study, different degrees of hyperosmolality induced by sodium chloride were investigated in anti-IgE rCHO cell fed-batch cultures and anti-CD52 rCHO cell perfusion cultures during the initial and stable phases. Read More

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December 2018

Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome.

Inflammation 2018 Dec 15. Epub 2018 Dec 15.

Department of Cardiology, Zhejiang Hospital, 12 Lingyin Road, Zhejiang, Hangzhou, China.

The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related to inflammatory suppression. JWH-133 was used for the activation of CB2R. Read More

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December 2018

Developmental Relations Between Listening and Reading Comprehension in Young Chinese Language Learners: A Longitudinal Study.

Authors:
Yu Ka Wong

J Psycholinguist Res 2018 Dec 15. Epub 2018 Dec 15.

Department of Curriculum and Instruction, Faculty of Education, The Chinese University of Hong Kong, Shatin, Hong Kong.

The reciprocal influences between the development of Chinese-as-a-second-language (CSL) listening and reading comprehension among young learners in Hong Kong were evaluated using a 2-year, three-wave longitudinal design. A total of 129 senior primary CSL students were assessed using listening and reading comprehension tests at the end of grades 4, 5, and 6. An autoregressive, cross-lagged model was specified, and it accounted for a substantial portion of variance (more than 60%) in the two comprehension abilities by grades 5 and 6. Read More

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December 2018

Impact of large-scale tree planting in Yunnan Province, China, on the water supply balance in Southeast Asia.

Environ Monit Assess 2018 Dec 15;191(1):20. Epub 2018 Dec 15.

Chongqing College of Arts and Sciences, Chongqing, 402160, China.

Along with rapid economic development and population growth, anthropogenic disturbances to natural ecosystems increase the progressively worsening environmental problems in and around water resources, making the potential ecological risks more severe and unpredictable. In order to cope with the increasingly serious issues related to the ecological environment and poverty alleviation, the Government of Yunnan in Southwest China launched a large-scale afforestation campaign (plantation forestry) on the Yunnan-Guizhou Plateau, which is the main source of several major river systems in Southeast Asia. In this study, we use GIS to investigate the impacts of a large-scale afforestation on the water storage balance of Southeast Asia. Read More

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December 2018

Classification of the superior angle of the scapula and its correlation with the suprascapular notch: a study on 303 scapulas.

Surg Radiol Anat 2018 Dec 15. Epub 2018 Dec 15.

Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.

Purpose: The aims of this study had been to classify the superior angle of the scapula based on morphological features, and to investigate its correlation with the suprascapular notch.

Methods: 303 samples of Chinese dried scapular specimens were collected from the Department of anatomy, Southwest Medical University. According to the anatomical morphological characteristics of the superior angle of the scapula, the morphological classification was performed to explore its correlation with the suprascapular notch (SSN). Read More

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December 2018

Unraveling the sources and fluorescence compositions of dissolved and particulate organic matter (DOM and POM) in Lake Taihu, China.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Taihu Laboratory for Lake Ecosystem Research, State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China.

Organic matter (OM), a complex entity with diverse functional groups and molecular sizes, has important effects on aquatic systems. We studied the optical compositions and sources of dissolved organic matter (DOM) and particulate organic matter (POM) in Lake Taihu, a large, shallow and eutrophic lake in China. Significant differences in optical compositions and sources occurred between the POM and DOM. Read More

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December 2018

Interaction of H. pylori with toll-like receptor 2-196 to -174 ins/del polymorphism is associated with gastric cancer susceptibility in southern China.

Int J Clin Oncol 2018 Dec 15. Epub 2018 Dec 15.

Department of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.

Background: Genetic polymorphisms of Toll-like receptors play important roles in gastric carcinogenesis. The aim of this study was to determine the role of TLR2-196 to -174 ins/del polymorphism in gastric cancer susceptibility and prognosis.

Methods: This study included 520 people from southern China. Read More

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December 2018

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study.

Med Sci Monit 2018 Dec 16;24:9136-9143. Epub 2018 Dec 16.

Sixth Affiliated Hospital, Kunming Medical University, Yuxi, Yunnan, China (mainland).

BACKGROUND This study aimed to investigate the relationship between serum profiles of prolactin and thyroid stimulating hormone (TSH) and sexual dysfunction in patients with schizophrenia treated with conventional antipsychotic medication. MATERIAL AND METHODS A hospital-based cross-sectional study included 118 patients, age range 18-57 years (55 men, 63 women), with a confirmed diagnosis of schizophrenia. All patients were stable after antipsychotic treatment. Read More

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December 2018

The REACH Trial: A Randomized Controlled Trial Assessing the Safety and Effectiveness of the Spiration® Valve System in the Treatment of Severe Emphysema.

Respiration 2018 Dec 14:1-12. Epub 2018 Dec 14.

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou,

Background: Chronic obstructive pulmonary disease (COPD) has become a leading cause of morbidity and mortality in China, with tobacco smoke, air pollution, and occupational biohazards being the major risk factors.

Objectives: The REACH trial is a multicenter, prospective, randomized controlled trial undertaken in China to assess the safety and effectiveness of the Spiration® Valve System (SVS) compared to standard medical care in COPD patients with severe emphysema.

Methods: Patients with severe airflow obstruction, hyperinflation, and severe dyspnea with interlobar fissure integrity were evaluated for enrollment. Read More

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December 2018

Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries.

Digestion 2018 Dec 14;99(1):86-94. Epub 2018 Dec 14.

Sino United Health Clinic, Gopher Medical Center, Rui Jing Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: To elucidate the current management of ulcerative colitis (UC)-associated cancer, a questionnaire-based survey was conducted to gather current opinions on colitis-associated cancer in different East Asian countries.

Methods: The questionnaire, based on physicians, contains 9 questions focused on UC management and cancer surveillance. In addition, the questionnaire based on neoplastic cases, which contains 17 questions, was collected and analyzed. Read More

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December 2018

Diffuse cavitary benign metastasising leiomyoma of the lung.

Thorax 2018 Dec 15. Epub 2018 Dec 15.

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

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December 2018

Risk of intracerebral haemorrhage in Chinese patients with atrial fibrillation on warfarin with cerebral microbleeds: the IPAAC-Warfarin study.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong

Background And Purpose: Cerebral microbleeds (CMBs), which predict future intracerebral haemorrhage (ICH), may guide anticoagulant decisions for atrial fibrillation (AF). We aimed to evaluate the risk of warfarin-associated ICH in Chinese patients with AF with CMBs.

Methods: In this prospective, observational, multicentre study, we recruited Chinese patients with AF who were on or intended to start anticoagulation with warfarin from six hospitals in Hong Kong. Read More

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December 2018

Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.

Eur J Med Chem 2018 Dec 7;163:560-568. Epub 2018 Dec 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in MDCK (Madin-Darby canine kidney) cells were evaluated. Read More

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December 2018

Exchanges of nitrogen and phosphorus across the sediment-water interface influenced by the external suspended particulate matter and the residual matter after dredging.

Environ Pollut 2018 Dec 5;246:207-216. Epub 2018 Dec 5.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, PR China; Jiangsu Provincial Key Laboratory of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, PR China.

Dredging is frequently implemented for the reduction of internal nitrogen (N) and phosphorus (P) loadings and the control of eutrophication. Residuals during dredging activities and external pollution loadings after dredging both commonly contribute to influence the effectiveness of dredging and have been widely discussed. In the current study, the exchanges of N and P across the sediment-water interface (SWI) to these two factors were compared in a six-month field incubation experiment. Read More

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December 2018

Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.

Biomed Pharmacother 2018 Dec 13;110:786-795. Epub 2018 Dec 13.

College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China. Electronic address:

Evodiamine (EVO), an extraction from the traditional Chinese medicine Evodia rutaecarpa, has been reported to possess anti-inflammatory, anti-tumor and other pharmacological activities. However, the effectiveness of EVO to relieve dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) has not been evaluated. In this study, the protective effects and mechanisms of EVO on DSS-induced UC mice were investigated. Read More

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December 2018

Protective role of Gentianella acuta on isoprenaline induced myocardial fibrosis in rats via inhibition of NF-κB pathway.

Biomed Pharmacother 2018 Dec 13;110:733-741. Epub 2018 Dec 13.

Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, PR China. Electronic address:

Gentianella acuta (Michx.) Hulten (G. acuta) has been widely used in Mongolian medicines for the treatment of cardiovascular diseases in Ewenki and Oroqen, Inner Mongolia autonomous region, China. Read More

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December 2018

Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 8;1105:15-25. Epub 2018 Dec 8.

Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:

A simple, sensitive and selective high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed and validated for simultaneous determination and pharmacokinetic study of 15 active compounds (Saikosaponin A, Baicalin, Wogonin, Glycyrrhizic acid, Glycyrrhetinic acid, Albiflorin, Paeoniflorin, Liquiritin, Isoliquiritin, Liquiritigenin, Isoliquiritigenin, Cinnamic acid, Gallic acid, Wogonoside and Oroxylin A) in rat plasma. After a feasible protein precipitation using methanol for sample preparation, chromatographic separation was carried out with a Halo® C column (2.1 × 100 mm, 2. Read More

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December 2018

Characterization of CDOM in saline and freshwater lakes across China using spectroscopic analysis.

Water Res 2018 Dec 8;150:403-417. Epub 2018 Dec 8.

Northeast Institute of Geography and Agroecology, CAS, Changchun 130102, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Colored dissolved organic matter (CDOM) is a major component of DOM in waters, and plays a vital role in carbon cycling in inland waters. In this study, the light absorption and three-dimensional excitation-emission matrix spectra (EEMs) of CDOM of 936 water samples collected in 2014-2017 from 234 lakes in five regions across China were examined to determine relationships between lake water sources (fresh versus saline) and their fluorescence/absorption characteristics. Results indicated significant differences regarding DOC concentration and a(254) between freshwater (6. Read More

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December 2018

Gender-specific prevalence of poor sleep quality and related factors in a Chinese rural population: the Henan Rural Cohort Study.

Sleep Med 2018 Nov 22;54:134-141. Epub 2018 Nov 22.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Objective: To estimate the prevalence of poor sleep quality and identify related factors by gender in the Chinese rural population.

Methods: Overall, 27424 subjects (10881 males and 16543 females) aged 18-79 years were enrolled from the Henan Rural Cohort Study. Sleep quality was evaluated by the standard Pittsburgh Sleep Quality Index (PSQI) and global score>5 was classified as poor sleep quality. Read More

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November 2018

Engineered nanomaterials inhibit Podosphaera pannosa infection on rose leaves by regulating phytohormones.

Environ Res 2018 Dec 6;170:1-6. Epub 2018 Dec 6.

Stockbridge School of Agriculture, University of Massachusetts Amherst, Amherst, MA 01003, United States.

In the present study, we investigated the antifungal effects of engineered nanomaterials (ENMs) against Podosphaera pannosa (P. pannosa), a fungal pathogen that causes powdery mildew on plants in the rose family. Four commercial ENMs, including multi-wall carbon nanotubes (MWCNTs), reduced graphene oxide (rGO), copper oxide (CuO) nanoparticles (NPs) and titanium dioxide (TiO) NPs, were used to prepare 50 or 200 mg/L NP suspensions in deionized water. Read More

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December 2018

Novel breviscapine nanocrystals modified by panax notoginseng saponins for enhancing bioavailability and synergistic anti-platelet aggregation effect.

Colloids Surf B Biointerfaces 2018 Nov 27;175:333-342. Epub 2018 Nov 27.

Jiangxi University of Traditional Chinese Medicine, 1688 Meilingdadao Road, Nanchang 330004, China.

Breviscapine (BVP) is a flavonoid compound with strong neuroprotective and anti-platelet aggregation effect. The objective of this study is to design novel BVP nanocrystals modified by natural panax notoginseng saponins (PNS) for enhancing dissolution and anti-platelet aggregation effect of BVP. BVP nanocrystals modified by PNS (BVP-NC/PNS) were firstly prepared by coupling homogenization technology and freeze-drying technology, and BVP nanocrystals modified by RH40 (BVP-NC/RH40) as reference for comparison. Read More

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November 2018

PERK is essential for proliferation of intestinal stem cells in mice.

Exp Cell Res 2018 Dec 14. Epub 2018 Dec 14.

Division of Emergency Medicine, Department of General Internal Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University, No.58, Zhongshan 2nd Road, Guangzhou, 510080, China. Electronic address:

Protein kinase RNA-like Endoplasmic Reticulum Kinase (PERK) is an endoplasmic reticulum stress sensor that possesses pro-survival capability and contributes to cell homeostasis and survival. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) has been recognized as a stem cell marker in intestinal epithelial cells. To determine whether PERK modulates the proliferation of intestinal stem cells, we investigated the effects of PERK knock-down on intestinal Lgr5-positive stem cells in mice. Read More

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December 2018

Fate of antibiotic resistance genes during anaerobic digestion of sewage sludge: Role of solids retention times in different configurations.

Bioresour Technol 2018 Dec 4;274:488-495. Epub 2018 Dec 4.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Water Pollution Control Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

In this study, three anaerobic digestion experiments were established to investigate the effects of solids retention times (SRT) on the fate of antibiotic resistance genes (ARGs) including anaerobic digestion of sewage sludge (CK), one-stage anaerobic digestion of microwave pretreatment sludge (MW) and two-stage anaerobic digestion of microwave pretreatment sludge (Acid stage and CH stage). The response of ARGs to the SRT varied significantly from ARG types and reactor configurations. Shorter SRT could avail the ARGs reduction for CK and two-stage digestion, while MW need longer SRT for the ARGs reduction. Read More

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December 2018

A novel computational solution to the health risk assessment of air pollution via joint toxicity prediction: A case study on selected PAH binary mixtures in particulate matters.

Ecotoxicol Environ Saf 2018 Dec 13;170:427-435. Epub 2018 Dec 13.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, PR China; Institute of Environment and Health, Jianghan University, Wuhan 430056, PR China. Electronic address:

Regional haze episode has already caused overwhelming public concern. Unraveling the health effects of the representative composition mixtures of atmospheric fine particulate matters (PM) becomes a top priority. In this study, a novel computational solution integrating chemical-induced genomic residual effect prediction with in vitro-based risk assessment is proposed to obtain the cumulative health risk of typical chemical mixtures of particulate matters (PM). Read More

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December 2018

Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Int Immunopharmacol 2018 Dec 13;67:186-193. Epub 2018 Dec 13.

Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China. Electronic address:

The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) contributes to cartilage and bone destruction in rheumatoid arthritis (RA). Betulinic acid has been demonstrated to have a positive therapeutic effect on tumor, inflammation and immune disorder, however, the effects of betulinic acid on RA FLSs have not been verified. Therefore, in the present study, we observed the effect of betulinic acid on the migration and invasion of RA FLSs and explored its underlying signal mechanisms. Read More

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December 2018

Use of probiotics in aquaculture of China-a review of the past decade.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Sino-Norway Fish Gastrointestinal Microbiota Joint Lab, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

China is the largest aquaculture producer in the world. Antibiotics were extensively used to ensure the development of the intensive aquaculture; however, the use of antibiotics causes safety- and environment-associated problems. As an alternative strategy to antibiotics, aquatic probiotics have attracted attention. Read More

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December 2018

A long noncoding RNA NR_045363 controls cardiomyocyte proliferation and cardiac repair.

J Mol Cell Cardiol 2018 Dec 13. Epub 2018 Dec 13.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address:

Long noncoding RNAs (lncRNAs) play important roles in the regulation of genes involved in cell proliferation. We have previously sought to more globally understand the differences of lncRNA expression between human fetal heart and adult heart to identify some functional lncRNAs which involve in the process of heart repair. We found that a highly conserved NR_045363 was mainly expressed in cardiomyocytes and rarely in non-cardiomyocytes. Read More

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December 2018

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Genomics Proteomics Bioinformatics 2018 Dec 13. Epub 2018 Dec 13.

State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences and School of Life Sciences, Peking University, Beijing 100871, China. Electronic address:

Rice is a major cereal crop for China. The development of the "three-line" hybrid rice system based on cytoplasmic male sterility in the 1970s (first-generation) and the "two-line" hybrid rice system based on photoperiod- and thermo-sensitive genic male-sterile lines (second-generation) in the 1980s has contributed significantly to rice yield increase and food security in China. Here we describe the development and implementation of the "third-generation" hybrid rice breeding system that is based on a transgenic approach to propagate and utilize stable recessive nuclear male sterile lines, and as such, the male sterile line and hybrid rice produced using such a system is non-transgenic. Read More

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December 2018

Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling.

J Ethnopharmacol 2018 Dec 13. Epub 2018 Dec 13.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Traditional Chinese Medicine, Nanfang hospital, Southern medical university, Guangzhou 510515, China. Electronic address:

Ethnopharmacological Relevance: Hepatocellular carcinoma (HCC) is among the most common malignancies. Signal transducer and activator of transcription 3 (STAT3), with abnormal expression and constitutive activation, has been reported to promote proliferation, metastasis, survival and angiogenesis of HCC cells. Rheum palmatum (RP), a traditional Chinese medicinal herb, exhibited tumor-suppressing effects in multiple human cancers, but its potential functions in HCC remain unexplored. Read More

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December 2018

LncRNAs in ovarian cancer.

Clin Chim Acta 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, Zhangjiagang First People's Hospital, Zhangjiagang 215600, Jiangsu, PR China. Electronic address:

Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. Read More

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December 2018

Three new capnosane-type diterpenoids from the South China Sea soft coral Lobophytum sp.

Fitoterapia 2018 Dec 13. Epub 2018 Dec 13.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address:

Three new diterpenoids with an unusual capnosane skeleton named lobophytrols A-C (1-3) were isolated from the South China Sea soft coral Lobophytum sp. along with one known related diterpene, (11S,12S,1E,3E,7E)-11,12-epoxycembra-1,3,7-triene (7). Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. Read More

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December 2018

A fungicide miconazole ameliorates tri-o-cresyl phosphate-induced demyelination through inhibition of ErbB/Akt pathway.

Neuropharmacology 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1-5 Beichenxilu Road, Beijing, 100101, China. Electronic address:

Organophosphorus compound (OP)-induced delayed neurotoxicity (OPIDN) is characterized by distal axonal degeneration and demyelination of the central and peripheral axons, which leads to progressive muscle weakness, ataxia and paralysis in several days after OP intoxication. This study aimed to investigate the possible use of an imidazole fungicide miconazole as a novel therapy for OPIDN. Adult hens, the most commonly used animal models in OPIDN studies, were orally given tri-o-cresyl phosphate (TOCP). Read More

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December 2018

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer.

Mol Metab 2018 Dec 5. Epub 2018 Dec 5.

Hunan Provincial Cancer Hospital and Cancer Hospital Affiliated to Xiangya Medical School, The Central South University, Changsha, Hunan 410013, China; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China; The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:

Background: Cancer cells favor the use of less efficient glycolysis rather than mitochondrial oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct metabolic alteration named the Warburg effect or aerobic glycolysis. In adult cells, bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB) family members are responsible for controlling the steady-state cytoplasmic levels of fructose-2,6-bisphosphate, which allosterically activates 6-phosphofructo-1-kinase, the key enzyme catalyzing the rate-limiting reaction of glycolysis. PFKFB3 and PFKFB4 are the two main isoenzymes overexpressed in various human cancers. Read More

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December 2018

Blind fMRI Source Unmixing via Higher-Order Tensor Decompositions.

J Neurosci Methods 2018 Dec 13. Epub 2018 Dec 13.

Computer Technology Institute & Press "Diophantus" (CTI), Greece; Dept. of Informatics and Telecommunications, National and Kapodistrian University of Athens, Greece; Chinese University of Hong Kong, Shenzhen, China.

Background: The growing interest in neuroimaging technologies generates a massive amount of biomedical data of high dimensionality. Tensor-based analysis of brain imaging data has been recognized as an effective analysis that exploits its inherent multi-way nature. In particular, the advantages of tensorial over matrix-based methods have previously been demonstrated in the context of functional magnetic resonance imaging (fMRI) source localization. Read More

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December 2018

Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria.

Bioorg Med Chem Lett 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address:

Novel biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety were designed, synthesized and evaluated for their antibacterial activity. The key compounds 7 and 9 were synthesized by the knoevenagel condensation of intermediate aldehyde 5 with rhodanine derivatives 6a-6b. The preliminary study showed that compounds 7, 9 and 10e exhibited potent antibacterial activity with MIC values of 0. Read More

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December 2018

Occlusion of an Extremely Large Left Atrial Appendage Using the "Double-LAmbre Technique".

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:

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December 2018

Diabetes mellitus and risk of pancreatic cancer in China: A meta-analysis based on 26 case-control studies.

Prim Care Diabetes 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030008, China.

Aims: The relationship between diabetes mellitus and pancreatic cancer risk from is uncertain based on the results of existing publications. The current report updated and re-evaluated the possible association between diabetes mellitus and pancreatic cancer risk in China.

Methods: Six databases (PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Database, and the Chinese National Knowledge Infrastructure) were used for the literature search up to October 2017. Read More

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December 2018

GWTG Risk Model for All Stroke Types Predicts In-Hospital and 3-Month Mortality in Chinese Patients with Acute Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. Electronic address:

Background: We aimed to externally validate the Get With the Guidelines (GWTG) risk model for all stroke types to predict in-hospital stroke mortality in Chinese patients and moreover to explore its prognostic value in predicting 3-month mortality after stroke.

Methods: The prognostic model was applied to patients with acute stroke from China National Stroke Registry II (CNSR II) to predict in-hospital and 3-month mortality. Model discrimination was estimated by calculating c-statistic and 95% confidence intervals (CIs). Read More

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December 2018

A case of pulmonary mucormycosis presented as Pancoast syndrome and bone destruction in an immunocompetent adult mimicking lung carcinoma.

J Mycol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Zhejiang Hospital, 12, Lingyin road, 310013 Hangzhou, China. Electronic address:

Pulmonary mucormycosis is a rare opportunistic infection caused by Mucormycosis. This fungal infection is uncommon in immunocompetent individuals. Because of its various clinical and imaging manifestations, it is a diagnostic challenge to distinguish pulmonary mucormycosis from other pulmonary diseases, such as carcinoma. Read More

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December 2018

Investigating the nonlinear effect of ego depletion on safety compliance: The moderating role of rumination.

J Safety Res 2018 Dec 25;67:27-35. Epub 2018 Sep 25.

Kidney Two Families, Heilongjiang Academy of Chinese Mediceal Sciences, 142 Sanfu Street, Xiangfang District, Harbin, China.

Introduction: A general view in previous research is that employees are reluctant to follow safe work procedures when confronting the shortage of self-control resources. However, this argument is constrained by the restricted view of ego depletion. To fill this gap, this study constructs the nonlinear relationship between ego depletion and safety compliance drawing from the perspective of dual-process theory. Read More

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December 2018

Dual-emitting film with cellulose nanocrystal-assisted carbon dots grafted SrAlO, Eu, Dy phosphors for temperature sensing.

Carbohydr Polym 2019 Feb 16;206:767-777. Epub 2018 Nov 16.

Center for Renewable Carbon, University of Tennessee, Knoxville, TN, 37996, USA. Electronic address:

In this study, we synthesized a novel dual-emitting fluorescent phosphor from cellulose nanocrystal (CNC)-assisted carbon dots (CDs)-grafted SrAlO, Eu, Dy (SAO) through a facile core-shell process. The CNC-CDs-coated SAO presents excellent scattered dual-emission and improved water resistance without destruction of the SrAlO crystals. The phosphors were then reacted with coupling amino-silane and assembled with nanofibrillated cellulose skeletons to create flexible isotropic films. Read More

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February 2019

Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts.

Carbohydr Polym 2019 Feb 13;206:493-503. Epub 2018 Nov 13.

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

In this paper, a series of 6-O-imidazole-based quaternary ammonium chitosan derivatives via 6-O-chloroacetyl chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FT-IR and H NMR spectroscopy, and elemental analysis. Furthermore, the antioxidant property against hydroxyl radicals, superoxide radicals, and DPPH radicals was evaluated in vitro. Read More

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February 2019

Inverse solubility of chitin/chitosan in aqueous alkali solvents at low temperature.

Carbohydr Polym 2019 Feb 15;206:487-492. Epub 2018 Nov 15.

National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Science, Wuhan 430071, People's Republic of China. Electronic address:

The low-temperature dissolving mechanism of chitin/chitosan in the alkali (LiOH, NaOH and KOH) aqueous solvents has not been well established yet. As revealed by our XRD and NMR methods, the prepared deacetylated chitins can be categorized as chitin (DA = 0.94-0. Read More

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February 2019

Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment.

Carbohydr Polym 2019 Feb 29;206:435-445. Epub 2018 Oct 29.

Agriculture Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, 524001, PR China.

Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. Read More

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February 2019
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