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    31515 results match your criteria Chinese Medical Journal [Journal]

    1 OF 631

    Pulmonary Hypertension in Glycogen Storage Disease Type II.
    Chin Med J (Engl) 2018 Jun;131(11):1375-1376
    National Clinical Research Center for Respiratory Disease; 0Center for Respiratory Disease, China-Japan Friendship Hospital, Beijing 100029, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

    Urinary Extracellular Vesicle: A Potential Source of Early Diagnostic and Therapeutic Biomarker in Diabetic Kidney Disease.
    Chin Med J (Engl) 2018 Jun;131(11):1357-1364
    Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
    Objective: Diabetic kidney disease (DKD) has become one of the major causes of end-stage renal disease. Urinary extracellular vesicles (uEVs) contain rich biological information which could be the ideal source for noninvasive biomarkers of DKD. This review discussed the potential early diagnostic and therapeutic values of proteins and microRNAs in uEVs in DKD. Read More

    Diagnostic Performance of Intestinal in Colorectal Cancer: A Meta-Analysis.
    Chin Med J (Engl) 2018 Jun;131(11):1349-1356
    Department of Gastroenterology and Hepatology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
    Background: Increasing evidence has supported the link of intestinal Fusobacterium nucleatum infection to colorectal cancer (CRC). However, the value of F. nucleatum as a biomarker in CRC detection has not been fully defined. Read More

    Lipoxin A4 Ameliorates Lipopolysaccharide-Induced A549 Cell Injury through Upregulation of N-myc Downstream-Regulated Gene-1.
    Chin Med J (Engl) 2018 Jun;131(11):1342-1348
    Department of Anesthesiology, 2nd Clinical Medical College of Jinan University; Department of Anesthesiology, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, China.
    Background: Lipoxin A4 (LXA4) can alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) and acute respiratory distress syndrome through promoting epithelial sodium channel (ENaC) expression in lung epithelial cells. However, how LXA4 promote ENaC expression is still largely elusive. The present study aimed to explore genes and signaling pathway involved in regulating ENaC expression induced by LXA4. Read More

    Cardiac Hypertrophy is Positively Regulated by MicroRNA‑24 in Rats
    Chin Med J (Engl) 2018 06;131(11):1333-1341
    Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
    Background: MicroRNA-24 (miR-24) plays an important role in heart failure by reducing the efficiency of myocardial excitation-contraction coupling. Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy. This study aimed to preliminarily investigate the function of miR-24 and its mechanisms in cardiac hypertrophy. Read More

    Establishment of a Quantitative Medical Technology Evaluation System and Indicators within Medical Institutions.
    Chin Med J (Engl) 2018 Jun;131(11):1327-1332
    Department of Medical Administration, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
    Background: The development and application of medical technologies reflect the medical quality and clinical capacity of a hospital. It is also an effective approach in upgrading medical service and core competitiveness among medical institutions. This study aimed to build a quantitative medical technology evaluation system through questionnaire survey within medical institutions to perform an assessment to medical technologies more objectively and accurately, and promote the management of medical quality technologies and ensure the medical safety of various operations among the hospitals. Read More

    Effect of Double-Balloon Enteroscopy on Diagnosis and Treatment of Small-Bowel Diseases.
    Chin Med J (Engl) 2018 Jun;131(11):1321-1326
    Department of Gastroenterology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, China.
    Background: The diagnosis and treatment of small-bowel diseases is clinically difficult. The purpose of this study was to evaluate the diagnostic and therapeutic value of double-balloon enteroscopy in small-bowel diseases.

    Methods: The history and outcomes of 2806 patients who underwent double-balloon enteroscopy from July 2004 to April 2017 were reviewed, which included 562 patients with obscure digestive tract bleeding, 457 patients with obscure diarrhea, 930 patients with obscure abdominal pain, 795 patients with obscure weight loss, and 62 patients with obscure intestinal obstruction. Read More

    Prognostic Value of Model for End-Stage Liver Disease Incorporating with Serum Sodium Score for Development of Acute Kidney Injury after Liver Transplantation.
    Chin Med J (Engl) 2018 Jun;131(11):1314-1320
    Department of Comparative Medicine, Fuzhou General Hospital, Fuzhou, Fujian 350025, China.
    Background: Contribution of model for end-stage liver disease incorporating with serum sodium (MELD-Na) score in predicting acute kidney injury (AKI) after orthotopic liver transplantation (OLT) is yet to be identified. This study assessed the prognostic value of MELD-Na score for the development of AKI following OLT.

    Methods: Preoperative and surgery-related variables of 321 adult end-stage liver disease patients who underwent OLT in Fuzhou General Hospital were collected. Read More

    Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over.
    Chin Med J (Engl) 2018 Jun;131(11):1308-1313
    Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
    Background: When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using of gonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis (EM) in patients aged 45 and over.

    Methods: This is a retrospective nested case-control study. Read More

    Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation.
    Chin Med J (Engl) 2018 Jun;131(11):1302-1307
    Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University; Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
    Background: Immunosuppressive agents are still inefficient in preventing biopsy-proven acute rejection (BPAR) after expanded criteria donor (ECD) kidney transplantation. The aim of this study was to investigate the relationships between early immunosuppressive exposure and the development of BPAR.

    Methods: We performed a retrospective study of 58 recipients of ECD kidney transplantation treated with enteric-coated-mycophenolate sodium, tacrolimus (Tac), and prednisone. Read More

    Fixation versus Excision of Osteochondral Fractures after Patellar Dislocations in Adolescent Patients: A Retrospective Cohort Study.
    Chin Med J (Engl) 2018 Jun;131(11):1296-1301
    Department of Sports Medicine, Hong-Hui Hospital, Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710054, China.
    Background: Patellar dislocation is one of the most common knee injuries in the adolescent population. It is often combined with osteochondral fracture. The purpose of this study was to compare the outcomes between fixation and excision of osteochondral fractures not involving the bearing surface in adolescent patients with patellar dislocations. Read More

    Human Leukocyte Antigen-A Allele Distribution in Nasopharyngeal Carcinoma Patients Showing Anti-Melanoma-Associated Antigen A or Synovial Sarcoma X-2 T Cell Response in Blood.
    Chin Med J (Engl) 2018 Jun;131(11):1289-1295
    Xinjiang Key Laboratory of Oncology, The Affiliated Tumor Hospital of Xinjiang Medical University; Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
    Background: Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma (NPC) patients. In this study, we evaluated the T cell response to melanoma-associated antigen (MAGE)-A1, MAGE-A3, or synovial sarcoma X-2 (SSX-2) in the peripheral blood of treatment-naive NPC patients. The relationship of responses among the three proteins and the human leukocyte antigen (HLA)-A types were analyzed to provide evidence of designing novel therapy. Read More

    Role of Soluble ST2 Levels and Beta-Blockers Dosage on Cardiovascular Events of Patients with Unselected ST-Segment Elevation Myocardial Infarction.
    Chin Med J (Engl) 2018 Jun;131(11):1282-1288
    Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan, Hubei 430022, China.
    Background: Serum soluble ST2 (sST2) levels are elevated early after acute myocardial infarction and are related to adverse left ventricular (LV) remodeling and cardiovascular outcomes in ST-segment elevation myocardial infarction (STEMI). Beta-blockers (BB) have been shown to improve LV remodeling and survival. However, the relationship between sST2, final therapeutic BB dose, and cardiovascular outcomes in STEMI patients remains unknown. Read More

    A Predictive Model for Estimation Risk of Proliferative Lupus Nephritis.
    Chin Med J (Engl) 2018 Jun;131(11):1275-1281
    Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong 510080; Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, Guangdong 510080; Guangdong Medical University, Zhanjiang, Guangdong 524023, China.
    Background: Lupus nephritis (LN) is classified by renal biopsy into proliferative and nonproliferative forms, with distinct prognoses, but renal biopsy is not available for every LN patient. The present study aimed to establish an alternate tool by building a predictive model to evaluate the probability of proliferative LN.

    Methods: In this retrospective cohort with biopsy-proven LN, 382 patients in development cohort, 193 in internal validation cohort, and 164 newly diagnosed patients in external validation cohort were selected. Read More

    Preliminary Outcome of Individualized Abdominoperineal Excision for Locally Advanced Low Rectal Cancer.
    Chin Med J (Engl) 2018 Jun;131(11):1268-1274
    Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
    Background: The introduction of individualized abdominoperineal excision (APE) may minimize operative trauma and reduce the rate of complications. The purpose of this study was to evaluate the safety and efficacy of individualized APE for low rectal cancer.

    Methods: Fifty-six patients who underwent individualized APE from June 2011 to June 2015 were evaluated retrospectively in Beijing Chaoyang Hospital, Capital Medical University. Read More

    Overall Blastocyst Quality, Trophectoderm Grade, and Inner Cell Mass Grade Predict Pregnancy Outcome in Euploid Blastocyst Transfer Cycles.
    Chin Med J (Engl) 2018 Jun;131(11):1261-1267
    Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing 100083, China.
    Background: Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological parameters best predict the outcomes of single blastocyst transfer. In addition, most of the previous studies did not exclude the effect of embryo aneuploidy on blastocysts transfer. Thus, the present study investigated the predictive value of various parameters on the pregnancy outcomes achieved via the transfer of frozen euploid blastocysts. Read More

    [Long-term efficacy of cervical artificial disc replacement for cervical degenerative diseases].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1358-1363
    Department of Spine Surgery, Beijing Jishuitan Hospital, Fourth Clinical Medical College of Peking University, Beijing 100035, China.
    To evaluate the long-term efficacy of cervical artificial disc replacement for patients with cervical disc herniation and degenerative cervical canal stenosis. Total of sixty-eight patients underwent single-level Bryan artificial disc replacement in Beijing Jishuitan Hospital from December 2003 to December 2007 with a minimum 10-year follow-up were retrospectively analyzed. There were 43 males and 25 females with a mean age of (46±8) years. Read More

    [Expression and distribution of programmed death receptor 1 and T cell immunoglobulin mucin 3 in breast cancer microenvironment and its relationship with clinicopathological features].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1352-1357
    Central Laboratory, the First Hospital of Jiaxing, Jiaxing 314001, China.
    To explore the expression and distribution of programmed death receptor 1 (PD-1) and T-cell immunoglobulin mucin 3 (TIM-3) in breast cancer microenvironment and analyze the their correlation with the clinicopathological features. The specimens of tumor tissue and adjacent tissues from 30 patients with infiltrative breast cancer who were diagnosed as breast cancer from June 2016 to May 2017 in The First Hospital of Jiaxing were collected, and the specimen were divided into two parts along the center. After embedding and cryosectioning, the expression and distribution of PD-1 and TIM-3 protein in tumor tissues were observed by immunofluorescence staining. Read More

    [The value of high resolution diffusion weighted imaging in differentiating benign and malignant epithelial tumors of parotid gland].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1347-1351
    Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
    To investigate the diagnostic value of RESOLVE DWI in the evaluation of benign and malignant epithelial tumors of parotid gland. A total of 106 patients in the First Affiliated Hospital of Zhengzhou University with epithelial tumors of parotid gland confirmed by pathology from July 2015 to October 2017 were retrospectively analyzed. All patients underwent preoperative routine MRI and RESOLVE DWI, the ADC average values were calculated, test were used to compare the ADC values of benign and malignant epithelial tumors of parotid gland. Read More

    [Comparison of prognostic value of (18)F-FDG PET/CT myocardial metabolism imaging and coronary collateral circulation in patients with CTO lesions].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1342-1346
    The 12th Ward, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
    To evaluate the location, extent of viable myocardial of chronic total coronary occlusions(CTO)lesions by (18)F-FDG PET myocardial metabolism imaging and then compare with coronary collateral circulation(CCC) to evaluate the prognostic evaluation in patients with CTO lesions. A total of Sixty consecutive patients with CTO lesions referred for viability assessment from April 2016 to April 2017 in Department of Cardiology, Beijing Anzhen Hospital were included in the study. These patients underwent (99m)Tc-sestamibi ECG-gated SPECT rest myocardial perfusion imaging and ECG-gated (18)F-FDG PET/CT myocardial metabolic imaging, as well as coronary arteriography were recruited in this study. Read More

    [Relationship between hyperuricemia and prognosis in patients with heart failure of coronary heart disease after revascularization].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1337-1341
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
    To explore the effect of hyperuricemia on prognosis in patients with heart failure of coronary heart disease (CHD) after revascularization. A single-center retrospective study of all subjects who underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) as revascularization for CHD at Beijing Anzhen Hospital, Capital Medical University, between January 2005 and December 2014 was performed.Patients were divided into two groups by with or without hyperuricemia. Read More

    [Application of low profile visualized intraluminal support (LVIS)stents in assisting coil embolization of intracranial aneurysms].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1333-1336
    Department of Neurosurgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China.
    To evaluate the safety and effectiveness of application of LVIS stent-assisted coiling endovascular procedures in cerebral aneurysms . The clinical data of 41 patients with intracranial aneurysms , which were performed in LVIS stent-assisted coiling endovascular therapies from June 2015 to October 2017 in The First Affiliated Hospital of Bengbu Medical College were analyzed retrospectively. 13 patients were unruptured and 28 patients were ruptured. Read More

    [The combined application of magnetic resonance DTI and 3D-pcASL in differential diagnosis of hyper-acute and acute ischemic cerebral infarction].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1327-1332
    Department of Radiology, Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224005, China.
    To explore the clinical value of magnetic resonance diffusion tensor imaging (DTI) combined with 3D pseudo continuous arterial spin labeling (3D-pcASL) perfusion imaging in differential diagnosis of hyper-acute and acute ischemic cerebral infarction. A total of 42 patients with confirmed unilateral ischemic cerebral infarction from February 2015 to October 2017 of Affiliated Yancheng Hospital of Southeast University Medical College were collected. DTI and 3D-pcASL images of hyper-acute (14 patients, group A) and acute (28 patients, group B) ischemic cerebral infarction were retrospectively analyzed. Read More

    [Genes polymorphism of BIN1 and ApoE in patients with amnestic mild cognitive impairment from Enshi Tujia area].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1322-1326
    Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
    To investigate the polymorphism of BIN1 and ApoE genes in amnestic mild cognitive impairment (aMCI) patients in Tujia minority area of Enshi, Hubei. A total of 107 patients with aMCI (aMCI group) and 150 healthy people (healthy control group) during the same period were included between December 2016 and October 2017 in Affiliated Minda Hospital of Hubei University for Nationalities, who were all the Tujia nationality. Three single nucleotide polymorphic site of BIN1 gene rs744373, rs7561528, rs6733839, and two single nucleotide polymorphic site of ApoE gene rs429358, rs7412, and Genotyping and sub-genotyping of ApoE genes were tested using ligase detection reaction technique(LDR), and gene polymorphisms of BIN1 and ApoE were analyzed with Logistic regression analysis. Read More

    [Dynamic retraction microneurosurgery for the treatment of medial tentorial meningiomas].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1317-1321
    Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    To investigate the effectiveness and clinical significance of dynamic retraction microneurosurgery for the treatment of medial tentorial meningiomas. From January 2011 to December 2016, a cohort of 28 patients with medial tentorial meningiomas were treated by microneurosurgery at the First Affiliated Hospital of Chongqing Medical University. Patients who treated intraoperatively with dynamic retraction surgery from January 2014 to December 2016 were assigned into dynamic retraction group, and those with fixed retractors intraoperatively from January 2011 to December 2013 were assigned into retractor group. Read More

    [Neuroendoscopy assisted microneurosurgery for posterior cranial fossa lesion].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1311-1316
    Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    To study the value of neuroendoscopy assisted microneurosurgery technique in the treatment of posterior cranial fossa lesion. Clinical data of 36 patients with posterior fossa lesions who accepted neuroendoscopy assisted microneurosurgery (NEAM group) in the department of neurosurgery of the First Affiliated Hospital of Chongqing Medical University, from January 2014 to December 2016, were retrospectively enrolled. A total of 113 cases diagnosed with the same lesions and accepted conventional microneurosurgery (non-NEAM group) in the same period were analyzed as control group. Read More

    [Staged transcranial and transsphenoidal surgery for giant pituitary adenomas: a retrospective study of 21 cases].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1306-1310
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
    To investigate the effect of the second-stage transcranial and transsphenoidal approach for giant pituitary tumors. A retrospective review of 21 patients, who had undergone the transcranial surgery and then transsphenoidal surgery for giant pituitary adenomas from 2012 to 2015 in the neurosurgery department of West China Hospital, was performed. Visual findings, endocrine presentation, complications, and tumor types were collected. Read More

    [Application of 3D virtual reality technology with multi-modality fusion in resection of glioma located in central sulcus region].
    Zhonghua Yi Xue Za Zhi 2018 May;98(17):1302-1305
    Department of Neurosurgery, the Third Military Medical University, Chongqing 400038, China.
    To explore the clinical and teaching application value of virtual reality technology in preoperative planning and intraoperative guide of glioma located in central sulcus region. Ten patients with glioma in the central sulcus region were proposed to surgical treatment. The neuro-imaging data, including CT, CTA, DSA, MRI, fMRI were input to 3dgo sczhry workstation for image fusion and 3D reconstruction. Read More

    [Effects of glycyrrhizic acid on ERK1/2 and p38 MAPK signaling pathway in a murine model of asthma].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1273-1278
    Department of Clinical Medicine, Nanjing Medical University, Nanjing 211166, China.
    To explore the effects of glycyrrhizic acid (GA) on Extracellular regulated protein kinases (ERK1/2) and p38 mitogen-activated protein kinases (p38 MAPK) signaling pathways in a murine model of asthma. Sixty female BALB/c mice were randomly divided into 6 groups (=10 each): a control group, an asthmatic group, two treatment groups with low and high doses of GA, U0126 group and SB203580 group. Within 24 hours after the last OVA challenge, histological studies of lung were conducted with the hematoxylin and eosin staining (HE) and alcian blue-periodic acid-Schiff (AB-PAS), the relative protein expression of ERK1/2 and p38 MAPK were detected by immunohistochemistry and Western blotting . Read More

    [Value of procalcitonin in predicting the severity and prognosis of neonates with septicemia].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1267-1272
    Department of Critical Medicine, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.
    To explore the value of procalcitonin(PCT) in predicting the severity and prognosis of neonates with septicemia. The clinical data of the hospitalized neonates over the age of 72 hours with double positive blood cultures from December 1st, 2011 to September 30, 2017 at the neonatal intensive care unit of Children's Hospital Affiliated to Capital Institute of Pediatrics was analyzed retrospectively. A total of 75 neonates were included in the study. Read More

    [Abnormal expression of angiopoietin-2 associated with invasion, metastasis and prognosis of lung cancer].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1261-1266
    Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China.
    To investigate the relationship between abnormal angiopoietin-2 (Ang-2) expression and invasion/metastasis of lung cancer. Totally 122 cases of postoperative primary lung cancer tissues and their paracancerous tissues from Jan. 2009 to Dec. Read More

    [Value of PET/CT in the prognosis of extranodal NK/T cell lymphoma].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1256-1260
    Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
    To explore the value of Positron-Emission Tomography/Computed Tomography (PET/CT) in the prognosis of extranodal NK/T cell lymphoma. The patients of NK/T cell lymphoma diagnosed from January 2007 to July 2016 in Department of Pathology of Beijing Tongren Hospital were enrolled in this study. Seventy-two in-hospital patients were examined on the invasion of adjecent tissue or organ by PET/CT. Read More

    [Prognostic significance of inflammatory indicators for advanced-stage diffuse large B-cell lymphoma].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1250-1255
    Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
    To explore the prognostic significance of inflammatory indicator, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), for advanced-stage diffuse large B-cell lymphoma (DLBCL). The data of advanced stage DLBCL cases was retrospectively collected, and all the patients were seen from January 2006 to December 2012 in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences. The patients were divided into the low NLR group (≤5∶1) and the high NLR group (>5∶1); the low PLR group (≤300∶1) and the high PLR group (>300∶1). Read More

    [Clinical observation of apatinib mesylate for the treatment of multi-drug resistant advanced breast cancer].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1246-1249
    Diagnosis and Treatment Center for Breast Cancer, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
    To assess the clinical efficacy and adverse outcomes of apatinib mesylate for the treatment of multi-drug resistant advanced breast cancer. A total of 24 patients with multi-drug-resistant advanced breast cancer who underwent apatinib mesylate treatment were retrospectively analyzed at the Diagnosis and Treatment Center for Breast Cancer of Henan Cancer Hospital. Patients were reviewed every 4 weeks after initial treatment and then every 8 weeks after stable disease. Read More

    [Effect of single nucleotide polymorphisms of RS1826690 located in UGT2B4 gene on the pathological complete response to neoadjuvant chemotherapy in breast cancer patients].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1242-1245
    Department of Combination of TCM and Western Medicine, Tumor Hospital Affiliated to Zhengzhou University, Zhengzhou 450008, China.
    To evaluate the association between single nucleotide polymorphisms (SNPs) of RS1826690 located in UGT2B4 gene and pathological complete response (pCR) to neoadjuvant chemotherapy in breast cancer patients. A total of 146 breast cancer patients were enrolled to detect the SNPs of RS1826690 by sequenom. The relationship between SNPs of RS1826690 and pCR, predictors of pCR were analyzed by univariate or multivariate analysis. Read More

    [Study of bioequiavailability of paclitaxel for Injection (Albumin Bound) and abraxane and the efficacy of extension treatments in patients with metastatic breast cancer].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1236-1241
    Department of Breast Cancer, Chinese PLA 307 Hospital, Beijing 100071, China.
    To compare the bioequiavailability of paclitaxel for injection (albumin bound) (PAB) and reference listed drug abraxane in the patients with metastatic breast cancer, and to investigate the safety and efficacy in the extension treatments of PAB. This study was random, two cycles, self-crossover control study in the bioequiavailability stage. PAB was the investigational drug T and Abraxane was the reference drug R. Read More

    [A multicenter, randomized, controlled, phase Ⅳ clinical study of PEG-rhG-CSF for preventing chemotherapy induced neutropenia in patients with breast cancer].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1231-1235
    Department of Breast Cancer 307 Hospital PLA, Beijing 100071, China.
    To explore the efficacy and safety of polyethylene glycal recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing chemotherapy-induced neutropenia in patiens with breast cancer. There were two parts in the present phase Ⅳ clinical study. One was a randomized, controlled clinical study. Read More

    [Etiological analysis on patients with vertigo or dizziness].
    Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1227-1230
    Department of Neurology, Baotou Central Hospital, Baotou 014040, China.
    To explore the spectrum of causes for patients with vertigo or dizziness in the Department of Neurology, and provide a reference for diagnosis and treatment of patients with vertigo or dizziness. Clinical data of patients in the Department of Neurology, Baotou Central Hospital between January 2016 and September 2017 was retrospectively analyzed. The target group under study was diagnosed based on the uniform diagnostic criteria. Read More

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