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    1 OF 623

    [Effect of picroside Ⅱ on the expression of mitochondrial VDAC1 after cerebral ischemia/reperfusion in rats].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):136-142
    Institute of Cerebrovascular Diseases, Affiliated Hospital of Qingdao University, Qingdao 266003, China.
    Objective: To explore the effect of picroside Ⅱ on the expression of mitochondrial voltage-dependent anion channel 1 (VDAC1) in rats after cerebral ischemiareperfusion. Methods: A total of 70 Wistar rats models with middle cerebral artery occlusionreperfusion (MCAO/R) were randomly divided into the sham group, model group, picroside (Picr) group, ruthenium red (RuR) group, RuR+ Picr group, Spermine (Sper) group, Sper+ Picr group (n=10 per group). Modified neurological severity scale (mNSS) was used to evaluated the neurobehavioral function, the expression of reactive oxygen species (ROS) in brain tissues were measured by enzyme-linked immunosorbent assay (ELISA), the morphology of brain tissues was observed by hematoxylin-eosin (HE) staining, the apoptotic cells were counted by terminal deoxynucleotidyl transferase dUTP nick end labeling assay (TUNEL), and the expressions of VDAC1 and endonuclease G (EndoG) were determined by immunohistochemical assay and Western blot. Read More

    [Development of a Chinese nomogram based on muti-parametric magnetic resonance for predicting the probability of prostate cancer in patients after initial negative biopsy].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):132-135
    Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China.
    Objective: To develop a predictive nomogram based on multi-parametric magnetic resonance imaging (mpMRI) information to identify men more likely to have a cancer diagnosed on repeat prostate biopsy. Methods: The clinical data of 237 patients who received repeat prostate biopsy after initial negative biopsy from Department of Urology of Peking University First Hospital between January 2001 and August 2016 was reviewed. Patient age, body mass index (BMI), serum total prostate-specific antigen (PSA), percent free PSA (f/t), prostate volume (PV), PSA density (PSAD), PSA velocity (PSAV), digital rectal examination (DRE), transrectal ultrasound (TRUS)and mpMRI results were included in the univariate and multivariate analysis. Read More

    [Diagnostic value of albumin-bilirubin grade combined with serum ammonia in cirrhosis with hepatic encephalopathy].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):127-131
    Clinical Laboratory Center, You'an Hospital, Capital Medical University, Beijing 100069, China.
    Objective: To explore the value of albumin-bilirubin (ALBI) grade combined with serum ammonia in the diagnosis of cirrhosis with hepatic encephalopathy (HE). Methods: The serum level of total bilirubin(TBIL), albumin( ALB )and blood ammonia were detected in 139 patients including 73 cirrhosis patients without HE and 66 cirrhosis patients with HE from January 2015 to January 2017 in Beijing You'an Hospital, and the relationship between ALBI and blood ammonia value and Child grade and hepatic encephalopathy was analyzed. Results: The level of ALBI and blood ammonia were more and more higher with the increase of Child grade, the level of ALBI in Child A, B and C were -2. Read More

    [Mechanisms of fosfomycin resistance of extended-spectrum β-lactamases-producing Escherichia coli and Klebsiella pneumoniae].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):122-126
    Department of Infectious Diseases of Sir Run Run Shaw Hospital, the Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
    Objective: To study the in vitro activity of fosfomycin to extended-spectrum β-lactamases (ESBLs)-producing Escherichia coli and Klebsiella pneumoniae and to explore the mechanisms of fosfomycin resistance. Methods: A total of 1 052 ESBLs-producing E. coli(ESBL-EC) and K. Read More

    [Analysis of genotype and hematological phenotype of 14 patients with coinheritance HKαα and South-East deletion thalassemia].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):117-121
    Department of Clinical Laboratoty, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
    Objective: To analyze the genotype-phenotype correlations among those thalassemia samples with the presence of -α(3.7,) --(SEA) and normal α(2) alleles on their α-globin gene clusters. Methods: Fourteen patients(including 1fetus, 4 males and 9 females, aged 0- 56 years old)who were suspected diagnosed by hematologic analysis and genetic testing among 16 080 participants in our laboratory since from August 2011 to August 2016, were enrolled. Read More

    [Comparison of percutaneous endoscopic lumbar discectomy versus transforaminal lumbar interbody fusion in treating upper lumbar disc herniation].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):113-116
    Department of Orthopedics, the First Affiliated Hospital of Luohe Medical College, Luohe 462000, China.
    Objective: To compare the efficacy of percutaneous endoscopic transforaminal discectomy (PTED) and transforaminal lumbar interbody fusion (TLIF) in the treatment of high lumbar disc herniation. Methods: The clinical data of patients with high lumbar disc herniation from February 2010 to February 2015 were retrospective analyzed. According to the inclusion criteria, a total of 63 cases were enrolled, including PTED group 33 cases, TLIF group 30 cases. Read More

    [A study on the effects and safety of sequential humidified high flow nasal cannula oxygenation therapy on the COPD patients after extubation].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):109-112
    Emergency Center, First Affiliated Hospital of Zhejiang University, Hangzhou 321000, China.
    Objective: To investigate and compare the effect and safety of nasal high-flow oxygen therapy (HFNCO) and noninvasive ventilation (NIV) therapy after extubation in patients with chronic obstructive pulmonary disease (COPD). Methods: All COPD patients subjected to mechanical ventilation in the Emergency Intensive Unit of the First Affiliated Hospital of Zhejiang University during January 2015 to June 2016 were included in the study. The patients were divided into two groups after extubation and HFNCO and NIV were adopted on each group respectively. Read More

    [Clinical features and prognosis of 18 cases of primary lymphocytic hypophysitis].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):102-108
    Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
    Objective: To analyze clinical features, prognosis and treatment of lymphocytic hypophysitis (LYH). Methods: The clinical data, treatments and outcomes of 18 cases diagnosed as LYH at Chinese PLA General Hospital between January 2001 and July 2017 was respectively reviewed. Results: Eighteen patients with histology-proven LYH (13 females and 5 males ) were identified. Read More

    [Incidence and short-term outcomes of acute kidney injury in very elderly patients].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):96-101
    Department of Health Care, South Building, Chinese PLA General Hospital, Beijing 100853, China.
    Objectives: To study the incidence, clinical characteristics, and prognostic impact of acute kidney injury (AKI) in very elderly patients. Methods: The very elderly patients (≥75 years) from the Geriatric Department of the Chinese PLA General Hospital between January 2007 and December 2015 were retrospectively enrolled. AKI was defined according to the 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria. Read More

    [Expression of high-mobility group box-Ⅰ and N-methyl-D-aspartate receptor in status epilepticus].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):51-55
    Department of Neurology, Baodi Clinical College of Tianjin Medical University, Tianjin 301800, China.
    Objective: To investigate the expression changes of high mobility group box-1 (HMGB1) and the 2B receptor of N- methyl -D- aspartate receptor (NR2B) in status epilepticus (SE). Methods: (1) Primary hippocampal neurons from SD rats with 16 to 18 days of fetal age were cultured in vitro for 7 days, and exposed to Mg(2+) free media for 3 hours. Those cultured neurons were randomly divided into control group and intermittent hypoxia group. Read More

    [microRNA targeted to chronic myeloid leukemia Bcr-Abl oncogene screen using deacetylase inhibitor].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):46-50
    Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming 650500, China.
    Objective: microRNA targeted to chronic myeloid leukemia Bcr-Abl oncogene were screened using the deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Methods: The proliferation inhibition effect of SAHA on chronic myeloid leukemia K562 cell was detected by MTS method, and the optimal concentration of SAHA reaction was determined. Western blot was used to detect the level of PARP protein, and making sure whether SAHA induced apoptosis of K562 cell. Read More

    [Pathogenesis of piriformis syndrome: a magnetic resonance imaging-based comparison study].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):42-45
    Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    Objective: To assess the morphological parameters of the piriformis muscle through magnetic resonance imaging(MRI) so as to further elucidate the pathogenesis of piriformis syndrome (PS). Methods: From September 2015 to October 2016, 30 suspected PS patients and 30 normal controls were enrolled in this study from the Nanfang Hospital, Southern Medical University. The possible causative factors of the PS in the patients were obtained, and the PS patients were divided into subgroups according to the anatomic site of the tender regions. Read More

    [Using creatinine reduction ratio as a predictor for delayed graft function of kindey transplant recipients from donor of cardiac death].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):36-41
    Department of Urology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China.
    Objective: To explore the relationship between creatinine reduction ratio (CRR) and delayed graft function among kidney transplant recipients from donor of cardiac death (DCD). To define the value of CRR to predict delayed graft function (DGF) in early post-transplant period. Method: 86 patients were included, who received renal transplantation from DCD during Jan 1(st) 2011 to Jun 30(th) 2016. Read More

    [Applied research of "quadri-low" combined with automatic tube current modulation and iterative model reconstruction technology in head and neck CT angiography].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):30-35
    Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou 215006, China.
    Objective: To investigate the feasibility of low tube voltage, low contrast medium concentration, injection rate and volume (quadri-low) combined with automatic tube current modulation (ATCM) and iterative model reconstruction (IMR) technology in head and neck CT angiography (CTA). Methods: A total of 70 patients whose body mass index (BMI)<25 kg/m(2) underwent head and neck CTA and digital subtraction angiography (DSA) from January to July 2017 were enrolled in this prospective study. According to random number table, patients were divided into two groups: group A (n=35) was scanned according to the protocol of 120 kV, 150 mAs, 50 ml and 5 ml/s iopromide (370 mg/ml) and filtered back projection (FBP) reconstruction; group B (n=35) was scanned with 80 kV, ATCM with mean tube current of 100 mAs, 30 ml and 3 ml/s iohexol (300 mg/ml) and IMR; the other parameters kept consistent between the two groups. Read More

    [Correlation between the parameters of acoustic cardiography and BNP, LVEF and cardiac function grading in patients with chronic heart failure].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):25-29
    Department of Cardiology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China.
    Objective: To explore the correlation between the parameters of the new generation of Acoustic Cardiography and brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) and cardiac function grading in the diagnosis of heart failure. Methods: One hundred and sixty-eight inpatients, who were hospitalized in Department of Cardiology, Haikou People's Hospital from May 2016 to July 2017, were enrolled as heart failure group, including NYHA class Ⅰ(n=29), NYHA class Ⅱ(n=40), NYHA class Ⅲ(n=64), NYHA class Ⅳ (n=35). And eighty-seven patients with normal cardiac function were selected as healthy control group. Read More

    [Hypopituitarism mode in patients with craniopharyngioma in relation to tumor growth pattern].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(1):19-24
    Department of Neurosurgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.
    Objective: To investigate the pituitary hormone changes of patients with craniopharyngioma of different growth patterns during perioperative period and follow up time. Methods: Retrospective studies were performed on 212 cases of primary craniopharyngioma patient who received total tumor excision surgery in our hospital from January 2001 to May 2012. The characteristics of pituitary hormone and associated clinical manifestation during preoperative, perioperative and postoperative periods were analyzed according to the QST surgical classification. Read More

    Pulmonary Capillary Hemangiomatosis without Pulmonary Hypertension: An Early Stage of Disease?
    Chin Med J (Engl) 2018 Jan;131(2):245-246
    Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University; State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong 510120, China.

    Radiotherapy for Gastrointestinal Stromal Tumors.
    Chin Med J (Engl) 2018 Jan;131(2):235-240
    Department of Radiation Oncology, Suleyman Demirel University, Isparta 32260, Turkey.
    Objective: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract, which frequently cause intraabdominal metastases. The current standard of care is surgery for localized cases, and adjuvant imatinib is recommended for tumors with a high risk of recurrence. To date, radiotherapy has not been commonly accepted as a part of multimodality treatment approach other than palliation. Read More

    Advances of Long Noncoding RNAs-mediated Regulation in Reproduction.
    Chin Med J (Engl) 2018 Jan;131(2):226-234
    Department of Clinical Laboratory, State Key Laboratory of Reproductive Medicine, Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, China.
    Objective: Advances in genomics and molecular biology have led to the discovery of a large group of uncharacterized long noncoding RNAs (lncRNAs). Emerging evidence indicated that many lncRNAs function in multiple biological processes and its dysregulation often causes diseases. Recent studies suggested that almost all regulatory lncRNAs interact with biological macromolecules such as DNA, RNA, and protein. Read More

    Effects of Matricaria chamomilla Extract on Growth and Maturation of Isolated Mouse Ovarian Follicles in a Three-dimensional Culture System.
    Chin Med J (Engl) 2018 Jan;131(2):218-225
    Department of Biology, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
    Background: The aim of this study was to design and assess the effects of hydroalcoholic extract of Matricaria chamomilla (MC) on preantral follicle culture of mouse ovaries in a three-dimensional culture system.

    Methods: Isolated preantral follicles were randomly divided into three main groups: the control group containing 10% fetal bovine serum without MC extract (G1), the first experimental group supplemented with 25 μg/ml hydroalcoholic extract of chamomile (G2), and the second experimental group supplemented with 50 μg/ml hydroalcoholic extract of chamomile (G3).

    Results: After 12 days of culture, the survival rate (P < 0. Read More

    In vitro Flow Perfusion Maintaining Long-term Viability of the Rat Groin Fat Flap: A Novel Model for Research on Large-scale Engineered Tissues.
    Chin Med J (Engl) 2018 Jan;131(2):213-217
    Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China.
    Background: Large-scale muscle tissue engineering remains a major challenge. An axial vascular pedicle and perfusion bioreactor are necessary for the development and maintenance of large-scale engineered muscle to ensure circulation within the construct. We aimed to develop a novel experimental model of a large-scale engineered muscle flap from an existing rat groin fat flap. Read More

    Differences of Matrix Metalloproteinase 2 Expression between Left and Right Ventricles in Response to Nandrolone Decanoate and/or Swimming Training in Mice.
    Chin Med J (Engl) 2018 Jan;131(2):207-212
    Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBER-CV, Murcia 30120, Spain.
    Background: Matrix metalloproteinase (MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs). We investigated the differences of MMP-2 expression between LV and RV in response to nandrolone decanoate (ND), swimming training (ST), and combined ND and ST (NS) in mice, based on their structural, functional, and biochemical characteristics.

    Methods: Totally 28 male C57B1 mice (6 weeks old; 20-23 g) were divided into four groups, including the control (n = 7), ND (n = 6), ST (n = 8), and NS (n = 7) groups. Read More

    Pedicle Subtraction Osteotomy with a Cage Prevents Sagittal Translation in the Correction of Kyphosis in Ankylosing Spondylitis.
    Chin Med J (Engl) 2018 Jan;131(2):200-206
    Department of Orthopaedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    Background: Sagittal translation (ST) is an accidental event that surgeons commonly encounter during a spinal osteotomy in the correction of kyphosis in ankylosing spondylitis (AS). However, there is a paucity of effective techniques to prevent ST. The purpose of this study was to propose a pedicle subtraction osteotomy (PSO) with a cage as a method to prevent ST and to explore the efficacy and feasibility of this method in the treatment of kyphosis in AS. Read More

    Glycosaminoglycan Content of the Lateral Compartment Cartilage in Knees Conforming to the Indications for Oxford Medial Unicompartmental Knee Arthroplasty.
    Chin Med J (Engl) 2018 Jan;131(2):194-199
    Department of Bone and Joint Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
    Background: The quality of the lateral compartment cartilage is important to preoperative evaluation and prognostic prediction of unicompartmental knee arthroplasty (UKA). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan (GAG) content in cartilage. This study aimed to determine the GAG content of the lateral compartment cartilage in knees scheduled to undergo Oxford medial UKA. Read More

    Reduction of Tat-interacting Protein 30 Expression Could be a Prognostic Marker in Bladder Urothelial Cancer.
    Chin Med J (Engl) 2018 Jan;131(2):188-193
    Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
    Background: Tat-interacting protein 30 (TIP30) has been reported to be a tumor suppressor, with reduced or absent expression in various tumors. However, its role in bladder urothelial cancer (BUC) has not been investigated. Therefore, herein, we investigated the expression of TIP30 protein in BUC and normal bladder mucosa and the clinical significance of TIP30 expression in the prognosis of BUC. Read More

    Potential Value of Datura stramonium Agglutinin-recognized Glycopatterns in Urinary Protein on Differential Diagnosis of Diabetic Nephropathy and Nondiabetic Renal Disease.
    Chin Med J (Engl) 2018 Jan;131(2):180-187
    Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China.
    Background: Diabetic nephropathy (DN) is the most common and serious microvascular complication of diabetes. To date, the gold standard for identifying DN and nondiabetic renal disease (NDRD) is a renal biopsy; however, there is currently no reliable diagnostic marker to identify DN and NDRD in a noninvasive manner. This study aimed to investigate the different glycopatterns in urine specimens of DN patients and NDRD patients for a differential diagnosis. Read More

    IL1F7 Gene Polymorphism Is not Associated with Rheumatoid Arthritis Susceptibility in the Northern Chinese Han Population: A Case-Control Study.
    Chin Med J (Engl) 2018 Jan;131(2):171-179
    Department of Rheumatology and Immunology, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing 100044, China.
    Background: Interleukin (IL)-37, also called IL1F7, is a natural inhibitor of inflammatory and immune responses. It is involved in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of IL1F7 gene polymorphism in RA susceptibility in a large cohort of patients. Read More

    Mechanism of Chronic Stress-induced Reduced Atherosclerotic Medial Area and Increased Plaque Instability in Rabbit Models of Chronic Stress.
    Chin Med J (Engl) 2018 Jan;131(2):161-170
    Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
    Background: Chronic stress contributes to increased risks of atherosclerotic diseases including heart disease, stroke, and transient ischemic attack. However, its underline mechanisms are poorly understood. This study aimed to elucidate the mechanism via which chronic stress exerts its effect on atherosclerosis (AS). Read More

    Utility and Safety of Intrathecal Methotrexate Treatment in Severe Anti-N-methyl-D-aspartate Receptor Encephalitis: A Pilot Study.
    Chin Med J (Engl) 2018 Jan;131(2):156-160
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Background: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a treatable autoimmune neurologic syndrome that occurs with or without tumor association. However, some severe cases are refractory to systemic immunotherapy. This pilot study aimed to evaluate the utility and safety of intrathecal methotrexate injection for severe patients with anti-NMDAR encephalitis who did not respond to first-line immunotherapy. Read More

    Screening for SH3TC2, PMP2, and BSCL2 Variants in a Cohort of Chinese Patients with Charcot-Marie-Tooth.
    Chin Med J (Engl) 2018 Jan;131(2):151-155
    Department of Neurology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410006, China.
    Background: SH3TC2, PMP2, and BSCL2 genes are related to autosomal recessive (AR) Charcot-Marie-Tooth (CMT) disease type 1, autosomal dominant (AD)-CMT1, and AD-CMT2, respectively. Pathogenic variants in these three genes were not well documented in Chinese CMT patients. Therefore, this study aims to detect SH3TC2, PMP2, and BSCL2 pathogenic variants in a cohort of 315 unrelated Chinese CMT families. Read More

    Muscle Magnetic Resonance Imaging for the Differentiation of Multiple Acyl-CoA Dehydrogenase Deficiency and Immune-mediated Necrotizing Myopathy.
    Chin Med J (Engl) 2018 Jan;131(2):144-150
    Department of Neurology, Peking University First Hospital, Beijing 100034, China.
    Background: Clinically, it is difficult to differentiate multiple acyl-CoA dehydrogenase deficiency (MADD) from immune-mediated necrotizing myopathy (IMNM) because they display similar symptoms. This study aimed to determine whether muscle magnetic resonance imaging (MRI) could be used for differential diagnosis between MADD and IMNM.

    Methods: The study evaluated 25 MADD patients, confirmed by muscle biopsy and ETFDH gene testing, and 30 IMNM patients, confirmed by muscle biopsy. Read More

    Early Neurological Deterioration after Recanalization Treatment in Patients with Acute Ischemic Stroke: A Retrospective Study.
    Chin Med J (Engl) 2018 Jan;131(2):137-143
    Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.
    Background: Early neurological deterioration (END) is a prominent issue after recanalization treatment. However, few studies have reported the characteristics of END after endovascular treatment (EVT) as so far. This study investigated the incidence, composition, and outcomes of END after intravenous recombinant tissue plasminogen activator (IV rt-PA) and EVT of acute ischemic stroke, and identified risk factors for END. Read More

    White Matter Lesions Predict Recurrent Vascular Events in Patients with Transient Ischemic Attacks.
    Chin Med J (Engl) 2018 Jan;131(2):130-136
    Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
    Background: White matter lesions (WMLs) are common findings in brain magnetic resonance imaging (MRI) and are strongly associated with stroke incidence, recurrence, and prognosis. However, the relationship between WMLs and transient ischemic attacks (TIAs) is not well established. This study aimed to determine the clinical significance of WMLs in patients with TIA. Read More

    [Experimental observation of hyperbaric oxygen combined with radioactive seed implantation in the treatment of nude mice bearing esophageal squamous cell carcinoma].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3821-3824
    Department of Oncology, Nanyang Central Hospital, Henan, Nanyang 473000, China.
    Objective: To investigate the effect and mechanism of hyperbaric oxygen combined with radioactive seed implantation in the treatment of esophageal squamous cell carcinoma. Methods: Subcutaneous tumor model of esophageal squamous cell carcinoma using TE-8 cells was established. Tumor bearing Balb/c(nu/nu) mice (60 mice) were divided into four groups, Cont group that treated with normal oxygen level, HBO group that treated with hyperbaric oxygen, RSI group that treated with radioactive seed implantation, and HBO+ RSI group that treated with hyperbaric oxygen combined with radioactive seed implantation. Read More

    [Expression and significance of autophagy in rabbit model of tracheal stenosis].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3816-3820
    Department of Respiratory, Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China (Gan Luoman is working in Qinghai University Medical College now).
    Objective: To investigate the expression and significance of autophagy in rabbit model of tracheal stenosis. Methods: A total of 18 rabbits were equally divided into 3 groups (blank control group, saline group, erythromycin group) in accordance with the random number table. After rabbit model of tracheal stenosis was established, no treatment was done with blank control group. Read More

    [Computer Aided Diagnosis system of breast ultrasound based on support vector machine: a clinical analysis].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3812-3815
    Department of Galactophore , Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China.
    Objective: To investigate the value of based on support vector machine (SVM) breast ultrasonography technology of Computer-Assisted diagnosis (CAD) for differential diagnosis of benign and malignant breast masses. Methods: Total of 143 patients who had 151 breast masses were collected in Fujian Maternity and Children Health Hospital or The Fist Affiliated Hospital of Fujian Medical University from June 2014 to December 2015. Based on pathological results as the gold standard, the diagnostic efficiency of CAD and ultrasonography were compared. Read More

    [Morphological characteristics and phenotypic analysis of multiple morphological abnormalities in sperm flagella].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3806-3811
    Center for Reproduction and Genetics, the First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu 210092, China.
    Objective: To analyze the sperm morphological characteristics of multiple morphological abnormalities of the sperm flagella (MMAF), and to analyze their common features and subtypes. Methods: Twenty-eight patients with abnormal morphology of flagella were analyzed by semen analysis. The morphological characteristics were analyzed by scanning electron microscopy and transmission electron microscopy. Read More

    [Association between small dense low-density lipoprotein cholesterol and carotid atherosclerosis].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3802-3805
    Department of Clinical Laboratory Medicine, Aerospace Center Hospital, Beijing 100049, China.
    Objective: To explore the association between small dense low-density lipoprotein cholesterol (sdLDL-C) and carotid atherosclerosis. Methods: 1 578 subjects were enrolled in an annual health check-up program in aerospace center hospital from 2016 to 2017, and these patients were divided into 471 cases (men 343 and women 128) with carotid atherosclerosis (subjects with increased carotid artery intima-media thickness or carotid atherosclerosis plaque) and 1 107 cases (men 567 and women 540) with non- carotid atherosclerosis according to ultrasonography. Serum sdLDL-C levels were measured by peroxidase assay. Read More

    [Risk factors and impacts on prognosis of ultrasound lung comets in patients undergoing hemodialysis].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3796-3801
    Department of Nephrology, Laiwu Municipal People's Hospital, Laiwu 271100, China.
    Objective: To investigate the risk factors of ultrasound lung comets and its impact on the survivals of patients undergoing hemodialysis. Methods: One hundred and forty-two patients on hemodialysis (Male 76, female 66) were divided into three groups according to the score of lung comets (mild: ≤14 comets; moderate: 15 to 30 comets; severe: >30 comets). Seventy-two healthy subjects examined by lung ultrasound serve as a control. Read More

    [Supplementation with high-dose L-carnitine on hemodialysis tolerance in uremic patients with severe heart diseases].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3792-3795
    Department of Nephrology, First Hospital of Tsinghua University, Beijing 100016, China.
    Objective: To investigate the effect of intravenous supplementation with high-dose L-carnitinen on hemodialysis tolerance in uremic patients with severe heart disease (ischemic heart disease, congestive heart disease and arrhythmia). Methods: Between March 2012 and March 2017, 5 gram L-carnitine was given after the completion of each hemodialysis treatment (3-4 times a week) over a period of two weeks in 29 maintenance hemodialysis patients with severe heart diseases manifested by frequently symptomatic hypotension, chest tightness, wheezing, palpitation, chest pain and other symptoms during hemodialysis. The hemodialysis duration, heart functional classification (New York Heart Association Functional Classification, NYHA ), blood pressure and arrhythmia were analyzed before and after the treatment. Read More

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