34,008 results match your criteria Chinese Medical Journal [Journal]


[The possible mechanisms of simvastatin on apoptosis of lung adenocarcinoma cells].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1988-1994

Departments of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

To explore the possible mechanisms of simvastatin-induced apoptosis in lung adenocarcinoma cells. The experiment was divided into control group (vehicle treated A549 cells), different concentrations (10, 20, 40, 80 mg/L) simvastatin group (simvastatin treated with different concentrations of A549 cells), aspartate specific proteinase (caspase) inhibitor (Z-VAD-FMK) group (50 μmol/L Z-VAD-FMK treated A549 cells), 40 mg/L simvastatin combined with Z-VAD-FMK group (40 mg/L simvastatin combined with 50 μmol/L Z-VAD-FMK co-treated A549 cells), interleukin-6 (IL-6) group (IL-6 acts on A549 cells) and different concentrations (10, 20, 40 mg/L) simvastatin combined with IL-6 group (simvastatin combined with IL-6 act on A549 cells). Cell counting kit-8 (CCK8) method was used to detect the effect on survival rate of lung adenocarcinoma A549 cells; Flow cytometry was used to detect the effect of simvastatin on A549 cell cycle; Mitochondrial membrane potential-1 (JC-1) fluorescent probe was wsed to detect the effect of simvastatin on mitochondrial membrane potential (MMP); Flow-type phosphatidl serine protein antibody Annexin V/propidium iodide (Annexin V-FITC/PI) double staining method was used to detect the effect of simvastatin on A549 cell apoptosis; CCK8 method was used to detect the effect of Z-VAD-FMK on the survival rate of A549 cells; TdT-mediated 2'-deoxyuridine 5'-triphosphate (dUTP) nick end labeling (TUNEL) method was used to detect the effect of Z-VAD-FMK on simvastatin-induced apoptosis in A549 cells; Western blot method was used to detect the effect of simvastatin on the expression levels of Janus kinase 2 and activation of signal transducers and activators of transcription 3 (JAK2/STAT3) pathway-related proteins phosphorylated JAK2 (p-JAK2), JAK2, phosphorylated STAT3 (p-STAT3), and STAT3 before and after the activator IL-6 of JAK2/STAT3 pathway acted on A549 cells. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200414-01189DOI Listing

[Analysis of comorbidity and polypharmacy in middle-aged and elderly patients].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1983-1987

Gastroenterology Department of Second Medical Center, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.

To investigate the characteristics of comorbidities and polypharmacy in middle-aged and elderly patients and assess the potential risk of drug-drug interactions. Retrospective analysis was carried out among the outpatients aged ≥45 years in the Second Medical Center of the PLA General Hospital from January to December 2016. The patient's comorbidities and polypharmacy were collected from the electronic medical records and annual physical examination reports. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200403-01066DOI Listing

[Effect of induction on maternal and neonatal outcomes of vaginal birth after cesarean].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1979-1982

Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

To investigate the effect of induction on maternal and neonatal outcomes of vaginal birth after cesarean section (VBAC). Retrospective cohort study. A total of 452 pregnant women who underwent trail of labor after cesarean section (TOLAC) from January 2015 to March 2019 of Beijing Obstetrics and Gynecology Hospital, Capital Medical University were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191213-02720DOI Listing

[Clinical application of the simultaneous detection of methotrexate and 7-hydroxymethotrexate in the delayed elimination for pediatric acute lymphoblastic leukemia].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1973-1978

Beijing Hospital, National Center of Gerontology, National Center for Clinical Laboratories, Graduate School of Peking Union Medical College, Beijing 100730, China.

To discuss the application value of the simultaneous determination of methotrexate (MTX) and 7-hydroxymethotrexate (7-OHMTX) in the delayed elimination of MTX for pediatric acute lymphoblastic leukemia (ALL). Cross sectional study. A total of 97 children who received 192 high-dose MTX treatments cycles in Lu Daopei Hospital from April to August 2019 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200424-01305DOI Listing

[Clinical value of early bedside ultrasound measurement of quadriceps femoris in diagnosis of ICU-acquired weakness].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1967-1972

School of Nursing, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100144, China.

To explore the correlation between quadriceps thickness (thickness of rectus femoris and vastus intermedius), cross-sectional area (cross-sectional area of the rectus femoris) and the strength score of the Medical Research Council (MRC) in critically ill patients, and to explore the changes in the length of hospital stay in the intensive care unit (ICU), and to determine the diagnostic value of muscle changes in the ICU-acquired weakness (ICU-AW). Patients admitted to the Department of Critical Care Medicine from March to October in 2019 who were expected to stay for more than five days were enrolled in this study. The cross-sectional area of the rectus femoris, the thickness of the rectus femoris, the thickness of the vastus intermedius on the first day of the ICU (D(1)), day 3 (D(3)), and day 5 (D(5)), day 7 (D(7)), out of ICU (D(ICU)), and the MRC muscle strength scores on the day of out of ICU prospectively were collected in all the patients, and the correlation and the regularity of quadriceps changes were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191129-02609DOI Listing

[Predictors for perioperative blood loss in pediatric patients with congenital scoliosis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1962-1966

Department of Orthopedics, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To identify predictors of massive blood loss after posterior hemivertebra resection for patients with congenital scoliosis. The data of 106 children with congenital scoliosis were collected from June 2017 to June 2019 in Beijing Children's Hospital. All the cases received posterior hemivertebra resection and internal fixation. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191201-02614DOI Listing

[Early efficacy of percutaneous endoscopic cervical discectomy with multimodal neurophysiological monitoring].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1956-1961

Henan Provincial People's Hospital of Henan University, Zhengzhou 450003, China.

To explore the clinical efficacy of percutaneous endoscopic cervical discectomy (PECD) assisted by neurophysiology monitoring (NM) in the treatment of cervical spondylotic radiculopathy (CSR). The clinical data of 55 patients with CSR treated in the Department of Spinal Surgery of Henan Provincial People's Hospital from April 2015 to May 2018 were analyzed retrospectively. Among them, 29 patients were treated with multi-mode NM-assisted PECD (NM group) and 26 patients with PECD alone (PECD group). Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191127-02572DOI Listing

[Clinical features of anti-myelin oligodendrocyte glycoprotein antibody-associated diseases in children with cortical encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1952-1955

Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

To describe the clinical features of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive cortical encephalitis in children. Patients who were hospitalized in Beijing Children's Hospital from June 2018 to October 2019, with positive MOG antibodies and phenotype of cortical encephalitis were retrospectively analyzed. Cell-based assays (CBAs) were used to test MOG antibodies. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200525-01644DOI Listing

[Clinical features and outcomes in relapsing and monophasic patients with anti-leucine-rich glioma-inactivated 1 encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1947-1951

Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To analyze the differences of clinical characteristics and outcomes between relapsing and monophasic patients with anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis. Medical records of confirmed anti-LGI1 encephalitic patients who underwent immunotherapy were retrospectively collected from January 2015 to January 2019 in the first affiliated hospital of Zhengzhou University. Clinical data, treatment methods, duration of treatment and outcomes were analyzed between the relapsing and monophasic groups. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200330-01001DOI Listing

[Cognitive function and cerebral blood perfusion changes in patients with anti-N-methyl-D-aspartate receptor encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1942-1946

Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

To investigated cognitive and cerebral blood flow changes in a cohort of patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Fifteen patients with confirmed anti-NMDAR encephalitis from the First Affiliated Hospital of Anhui Medical University and the First Affiliated Hospital of University of Science and Technology of China between June 2015 and February 2019 were included in the study. Meanwhile, another 15 healthy subjects were selected as controls. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200108-00050DOI Listing

[Clinical approach and prognosis of continuous neurological care after intensive care for the patients with severe and refractory anti-N-methyl-D-aspartate receptor encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1937-1941

Department of Neurology, Yuquan Hospital, Tsinghua University, Beijing 100040, China.

To study the clinical features, continuous care and prognosis of the patients with severe and refractory anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis after intensive care unit (ICU). Clinical data of patients with severe and refractory anti-NMDAR encephalitis, who were transferred from ICU to general ward of neurology between December 2015 and October 2019, were retrospectively reviewed and analyzed in the study. Twenty patients (11 females and 9 males) were enrolled in the study. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191219-02776DOI Listing

[Clinical featuers of adult patients with post-viral-encephalitis autoimmune encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1933-1936

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To explore the clinical features of post-viral-encephalitis autoimmune encephalitis (PVEAE). Ten cases of PVEAE, who were hospitalized in the Neurology Department of Peking Union Medical College Hospital (PUMCH) between November 2014 and October 2019, were retrospectively reviewed. Clinical manifestation, immunology, neuroradiology, treatment and outcomes were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200115-00095DOI Listing

[Technological specification of extracranial non-gasserian ganglion radiofrequency ablation for treatment of trigeminal neuralgia by CT-guidance].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1929-1932

Department of Pain Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

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http://dx.doi.org/10.3760/cma.j.cn112137-20200309-00661DOI Listing

[A comprehensive understanding of anti-contactin associated protein-like 2 antibody encephalitis].

Authors:
J Wu S Zhang

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1925-1928

Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

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http://dx.doi.org/10.3760/cma.j.cn112137-20200110-00070DOI Listing

[The challenge of identification and diagnosis of emerging viral encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1921-1924

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

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http://dx.doi.org/10.3760/cma.j.cn112137-20200325-00931DOI Listing

Prognostic value of free triiodothyronine in patients with dilated cardiomyopathy.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Background: The association between free triiodothyronine (FT3) and long-term prognosis in dilated cardiomyopathy (DCM) patients has not been evaluated. The purpose of this study was to determine whether the level of FT3 could provide prognostic value in patients with DCM.

Methods: Data of consecutive patients diagnosed with DCM were collected from October 2009 to December 2014. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000896DOI Listing

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurology, Liangxiang Hospital of Beijing Fangshan District, Beijing 102246, China.

Background: Early neurologic deterioration (END) may occur in patients with anterior circulation ischemic stroke (ACIS) after receiving endovascular treatment (EVT). Hemodynamic insufficiency, re-occlusion, and post-re-canalization hyper-perfusion are likely to play a critical role in END. We hypothesized that hemodynamic changes can predict END in patients with ACIS post-successful EVT using trans-cranial Doppler (TCD). Read More

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http://dx.doi.org/10.1097/CM9.0000000000000881DOI Listing

Zinc finger and BTB domain-containing protein 46 is essential for survival and proliferation of acute myeloid leukemia cell line but dispensable for normal hematopoiesis.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.

Background: Zinc finger and BTB domain-containing protein 46 (Zbtb46) is a transcription factor identified in classical dendritic cells, and maintains dendritic cell quiescence in a steady state. Zbtb46 has been reported to be a negative indicator of acute myeloid leukemia (AML). We found that Zbtb46 was expressed at a relatively higher level in hematopoietic stem and progenitor cells (HSPCs) compared to mature cells, and higher in AML cells compared to normal bone marrow (BM) cells. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000878DOI Listing

A guide to human microbiome research: study design, sample collection, and bioinformatics analysis.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

The purpose of this review is to provide medical researchers, especially those without a bioinformatics background, with an easy-to-understand summary of the concepts and technologies used in microbiome research. First, we define primary concepts such as microbiota, microbiome, and metagenome. Then, we discuss study design schemes, the methods of sample size calculation, and the methods for improving the reliability of research. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000871DOI Listing

Small airway immunoglobulin A profile in emphysema-predominant chronic obstructive pulmonary disease.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Department of Respiratory Medicine, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi 030032, China.

Background: Due to airway remodeling and emphysematous destruction in the lung, the two classical clinical phenotypes of chronic obstructive pulmonary disease (COPD) are emphysema and bronchiolitis. The present study was designed to investigate the levels of small airway immunoglobulin A (IgA) in COPD with "emphysema phenotype." The study also evaluated the associations between the small airway IgA levels and the severity of disease by the extent of emphysema versus airflow limitation. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000863DOI Listing

Assessment and management of low anterior resection syndrome after sphincter preserving surgery for rectal cancer.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Division of Colorectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

Many patients develop a variety of bowel dysfunction after sphincter preserving surgeries (SPS) for rectal cancer. The bowel dysfunction usually manifests in the form of low anterior resection syndrome (LARS), which has a negative impact on the patients' quality of life. This study reviewed the LARS after SPS, its mechanism, risk factors, diagnosis, prevention, and treatment based on previously published studies. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000852DOI Listing

Relationship between quantitative magnetic resonance imaging and clinical symptoms in patients with knee osteoarthritis.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China.

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http://dx.doi.org/10.1097/CM9.0000000000000879DOI Listing

Association of serum zinc-α2-glycoprotein with non-alcoholic fatty liver disease.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China.

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http://dx.doi.org/10.1097/CM9.0000000000000873DOI Listing
June 2020
1.016 Impact Factor

Clinical significance of nuchal translucency measurement in routine prenatal examination.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

Department of Prenatal Diagnostic Center, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.

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http://dx.doi.org/10.1097/CM9.0000000000000895DOI Listing

Successful treatment of cutaneous mucormycosis disseminated from pulmonary mucormycosis with liposomal amphotericin B and posaconazole.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

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http://dx.doi.org/10.1097/CM9.0000000000000891DOI Listing

Polycyclic aromatic hydrocarbon: environmental sources, associations with altered lung function and potential mechanisms.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

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http://dx.doi.org/10.1097/CM9.0000000000000880DOI Listing

Health effects of air pollution: a Southern European perspective.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

National Research Council (NCR) Institute for Biomedical Research and Innovation (IRIB), 90146 Palermo, Italy.

Objective: To summarize the main updated evidence about the health effects of air pollution, with a special focus on Southern Europe.

Data Sources: Literature was obtained through PubMed Central and the official websites of European Agencies and Scientific Societies.

Study Selection: Recent shreds of evidence about the health effects of air pollution coming from international reports and original research were collected and described in this review. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000869DOI Listing

Climate change, air pollution, and allergic respiratory diseases: a call to action for health professionals.

Chin Med J (Engl) 2020 Jun 24. Epub 2020 Jun 24.

School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Rising emissions of greenhouse gases in the atmosphere have warmed the planet substantially and are also accompanied by poor air quality. The increased prevalence of allergic airway disease worldwide can be partially attributed to those global environmental changes. Climate change and air pollution pose adverse impacts on respiratory allergies, and that the mechanisms are complex and interactive. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000861DOI Listing

[Level and trend of respiratory diseases mortality in China from 2002 to 2016].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1895-1900

Department of Clinical Epidemiology and Tobacco Dependence Treatment Research, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To analyze the level and trend of respiratory disease mortality in China from 2002 to 2016. The standardized mortality rates were calculated based on the China health statistics yearbook (2003-2012) and China statistical yearbook of health and family planning (2013-2017) data released by the statistical information center of National health Commission of the People's Republic of China. Joinpoint model was used to calculate the standardized mortality rates (SMR), Annual percentage change (APC) and the average annual percentage change (AAPC) for standardized mortality rates. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191108-02430DOI Listing

[The role of Wnt/β-catenin/TCF-4 pathway on biological behavior of renal cell carcinoma and its mechanism].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1890-1894

Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.

To investigate the role of Wnt/β-catenin/TCF-4 pathway in renal cancer cells and to analyze its possible mechanism. β-catenin and TCF-4 were inhibited by siRNA in 786-O cells. The proliferation of transfected cells was detected by CCK8. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191107-02418DOI Listing

[Lymphocyte activation gene 3 expression on T lymphocyte cell subsets in patients with myelodysplastic syndrome].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1886-1889

Hematology Department, Tianjin Medical University General Hospital, Tianjin 300052, China.

To investigate the expression of Lymphocyte activation gene 3 (LAG3) in myelodysplastic syndromes (MDS) patients. A total of 16 MDS patients newly diagnosed in Hematology Department of Tianjin Medical University were enrolled from January to November 2019. The healthy control (HC) group includes 16 cases of healthy adults. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200217-00322DOI Listing

[Analysis of survival and prognosis of Siewert Ⅱ/Ⅲ esophagogastric junction adenocarcinoma patients with non-operative acute upper gastrointestinal hemorrhage].

Authors:
L Tian L Yu

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1881-1885

Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze the clinical characteristics and risk factors of non-operative acute upper gastrointestinal hemorrhage in patients with adenocarcinoma of the esophagogastric junction. The clinical diagnosis and treatment data of patients with adenocarcinoma of esophagogastric junction with non-operative acute upper gastrointestinal hemorrhage admitted to Cancer Hospital of Chinese Academy of Medical Sciences from 2004 to 2018 were collected retrospectively, and the survival of patients was followed up by telephone. SPSS software was used for database establishment and analysis. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200404-01082DOI Listing

[The application of medical alliance mode inexercise rehabilitation management of patients after percutaneous coronary interventioninchest paincenter].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1877-1880

Chest Pain Center, Yancheng Third People's Hospital, The Affiliated Yanchen Hospital of Southeast University, Yancheng 224000, China.

To explore the comprehensive effect of exercise-based cardia crehabilitation in patients managed with medical alliance who have undergone percutaneous coronary intervention (PCI) from Chest Pain Center. A total of 91 post PCI patients with coronary atherosclerotic heart disease were enrolled into the study. Fifty-four patients were in exercise rehabilitation group and 37 patients were in control group according to whether they were managed with medical alliance. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200328-00985DOI Listing

[Application of Endo-GIA stapler in laparoscopic radicalcystectomy].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1872-1876

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To explore the application of Endo-GIA stapler in laparoscopic radical cystectomy, especially in the treatment of lateral bladder ligament, and to evaluate its clinical feasibility and practicability. A retrospective analysis of clinical data about 38 cases of laparoscopic radical cystectomy (LRC) treated in the Department of Urology, Chaoyang Hospital of Beijing and Cancer Hospital, Chinese Academy of Medical Sciences from July 2017 to June 2019 were conducted. The patients were divided into Endo-GIA stopler group(18 cases) and non-Endo-GIA stopler group (20 cases) according to whether Endo-GIA stapler were used. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190925-02112DOI Listing

[Clinical analysis of mediastinal lymph node dissection through sternotomy approach in the treatment of papillary thyroid carcinoma with mediastinal lymph node metastasis].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1866-1871

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the rule of mediastinal lymph node metastasis of papillary thyroid carcinoma and the application of therapeutic mediastinal lymph node dissection through the sternotomy approach in the treatment of mediastinal lymph node metastasis of papillary thyroid carcinoma. All cases of papillary thyroid carcinoma with mediastinal lymph node metastasis treated through sternotomy cooperated by thoracic surgeons and head and neck surgeons from January 2006 to January 2017 in Cancer Hospital of Chinese Academy of Medical Sciences were included in this study. The distribution, metastasis rate, metastasis degree, surgical method, surgical complications and postoperative survival of patients with mediastinal lymph node metastasis were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200428-01353DOI Listing

[Clinical characteristics of patients with antisynthetase syndrome and interstitial pulmonary disease].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1861-1865

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital/Institute of Respiratory Medicine, Chinese Academy of Medical Sciences/National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.

To provide reference for clinicians in diagnosis and treatment of antisynthetase syndrome with interstitial pulmonary disease (ASS-ILD) by analyzing the clinical features, imaging features and pulmonary function changes of ASS-ILD patients. A total of 92 patients with ASS-ILD diagnosed in the Respiratory Center of China-Japan Friendship Hospital from January 2015 to May 2018 were included, clinical manifestations, high-resolution computed tomography (HRCT), pulmonary function test, treatment and outcome were retrospectively analyzed. The average age of the 92 patients was (58. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191120-02521DOI Listing

[Comparison of islet autoantigen-specific T cell response detected by direct enzyme-linked immunospot (ELISPOT) assay and accelerated co-cultured dendritic cells (acDCs) assay].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1856-1860

Department of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, the Second Xiangya Hospital, Central South University, National Clinical Research Center for Metabolic Diseases, Changsha 410011, China.

To investigate the effect of enzyme-linked immunospot (ELISPOT) on accelerated co-cultured dendritic cells (acDCs) and direct detection of islet full-length antigen-specific T cell response in peripheral blood of patients with type 1 diabetes mellitus (T1DM). Sixteen patients with T1DM[9 males, 7 females, mean age(28.5±9. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191128-02591DOI Listing

[Clinical characteristics of testicular adrenal rest tumor and factors associated with its occurrence in 21-hydroxylase deficiency patients].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1850-1855

Department of Endocrinology, Peking Union Medical College Hospital, Key Laboratory of Endocrinology, National Health Commission, Beijing 100730, China.

To analyze the occurrence and clinical characteristics of testicular adrenal rest tumor (TART) in 21-hydroxylase deficiency (21-OHD) patients, and further explore the possible factors related to the occurrence of TART. Twenty-seven male 21-OHD patients who visited Peking Union Medical College Hospital from January to December 2018 were enrolled and their clinical and biochemical data were collected. The CYP21A2 mutations were identified by Sanger sequencing and multiple ligation probe amplification (MLPA). Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191104-02389DOI Listing

Gut inflammation in the pathogenesis of acquired aplastic anemia.

Chin Med J (Engl) 2020 Jun 18. Epub 2020 Jun 18.

Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China.

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http://dx.doi.org/10.1097/CM9.0000000000000772DOI Listing

Establishment of endometriotic models: the past and future.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Endometriosis is a prevalent chronic disease that affects approximately 6% to 10% of reproductive-aged women. Although numerous researchers have endeavored to explore the etiology of endometriosis over a century, its etiology still remains an enigma. The exploration of pathophysiologic mechanism and novel therapy for endometriosis depends on ideal endometriotic models. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000885DOI Listing

Multislice spiral computed tomography imaging in evaluating hemophilic arthropathy.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Department of Medical Imaging, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Central China Fuwai Hospital, Zhengzhou, Henan 450003, China.

Background: Certain hemophilia patients are unable to cooperate with or afford magnetic resonance imaging (MRI) examinations. The purpose of our study was to explore the value of multislice spiral computed tomography (MSCT) in evaluating hemophilic arthropathy (HA).

Methods: Thirty-eight patients with 73 joints of HA were consecutively selected from January 2016 to May 2018 for this prospective study. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000876DOI Listing

Risk factors and possible mechanisms of saphenous vein graft failure after coronary artery bypass surgery.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Department of Cardiovascular Surgery, Tianjin Chest Hospital, Tianjin 300222, China.

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http://dx.doi.org/10.1097/CM9.0000000000000872DOI Listing

Effect of temperature maintenance by forced-air warming blankets of different temperatures on changes in inflammatory factors in children undergoing congenital hip dislocation surgery.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Department of Operation Room, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.

Background: Hypothermia is associated with many adverse clinical outcomes in pediatric patients, and thus, it is important to find an effective and safe method for preventing peri-operative hypothermia and its associated adverse outcomes in pediatric patients. This study aimed to investigate the effect of forced-air warming blankets with different temperatures on changes in the transforming growth factor-β (TGF-β), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-10 levels in children undergoing surgical treatment for developmental displacement of the hip (DDH).

Methods: The study included 123 children undergoing surgery for DDH under general anesthesia. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000846DOI Listing

More mutation accumulation in Neisseria gonorrhoeae (NG) with susceptibility than that in NG with decreased susceptibility to ceftriaxone.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, China.

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http://dx.doi.org/10.1097/CM9.0000000000000884DOI Listing

Global lung cancer mortality trends and lifestyle modifications: preliminary analysis.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

High School of Health Administration, First Moscow Medical Academy, Moscow 119991, Russia.

Background: According to the Independent High-level Commission on Non-communicable Diseases (NCD) of the World Health Organization (WHO), global reduction in lung cancer mortality has been achieved since the year 2000, although this effect is not sufficient to reach the 30% reduction of mortality from NCDs by the year 2030, as stipulated by the United Nations Sustainable Development Goal 3.4. The objective of this study was to analyze whether the lifestyle changes implemented by the WHO at country level could have an impact on mortality from this form of cancer. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000918DOI Listing

Global alliance against chronic respiratory diseases demonstration project: aerosol pollution and its seasonal peculiarities in primary schools of Vilnius.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Department of Public Health, Institute of Health Sciences, and Department of Children's Diseases, Institute of Clinical Medicine, Vilnius University Faculty of Medicine, LT-03101 Vilnius, Lithuania.

Background: The growing public health concern caused by non-communicable diseases in urban surroundings cannot be solved by health care alone; therefore - a multidisciplinary approach is mandatory. This study aimed to evaluate the airborne aerosol pollution level in primary schools as possible factor influencing origin and course of the diseases in children.

Methods: Seasonal aerosol particle number concentration (PNC) and mass concentration (PMC) were studied in the randomly selected eleven primary schools in the Lithuanian capital, Vilnius, as model of a middle-size Eastern European city. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000913DOI Listing

Herpes simplex virus associated sepsis in an immunocompetent adult: the value of next-generation sequencing.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

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http://dx.doi.org/10.1097/CM9.0000000000000893DOI Listing

Global Alliance against Chronic Respiratory Diseases symposium on air pollution: overview and highlights.

Chin Med J (Engl) 2020 Jun 19. Epub 2020 Jun 19.

Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine M/C 719, University of Illinois at Chicago, 840 S. Wood St., Chicago, IL 60612, USA.

A 1-day symposium before the annual meeting of the Global Alliance against Chronic Respiratory Diseases, gathered authorities and researchers from around the world to discuss the impact of air pollution on human and planetary health. Air quality is a high priority for Global Alliance against Chronic Respiratory Diseases and China, the host country. This article presents a summary, commentary, and amplification of the 17 presentations. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000877DOI Listing