840,099 results match your criteria Chinese Journal Of Polymer Science[Journal]


Outcomes and factors associated with early mortality in pediatric post-cardiotomy veno-arterial extracorporeal membrane oxygenation.

Artif Organs 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Mortality and morbidity of children received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery remain high despite remarkable advances in medical management and devices. The purpose of this study was to describe outcomes and risk factors of applying VA-ECMO in the surgical pediatric population. We retrospectively analyzed 85 consecutive pediatric patients (aged <18 years) who received post-cardiotomy VA-ECMO from January 2010 to December 2018. Read More

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http://dx.doi.org/10.1111/aor.13773DOI Listing

A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, People's Republic of China.

Fungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera , and are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus , which has been reported to possess great potential for its application as a biocontrol agent. Read More

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http://dx.doi.org/10.1055/a-1196-1906DOI Listing

Cytotoxic and Anti-inflammatory Terpenoids from the Whole Plant of Vaccinium emarginatum.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.

Two new Δ ursene-type triterpenoid coumaroyl esters (1: and 2: ), one new Δ isopimarane-type diterpenoid glycoside (20: ), and two new irido--lactone-type iridoids (21: and 22: ), together with 17 known pentacyclic triterpenoids (3:  - 19: ), were isolated during the phytochemical investigation of a methanol extract of the whole plant of . Their structures were determined by detailed analysis of standard spectroscopic data (MS, IR, 1D, and 2D NMR) and comparison with data of known analogs. The isolates were evaluated for their cytotoxicity against the PC-3 and Du145 prostate cancer cell lines (as assessed by an MTT cell proliferation assay), as well as for their anti-inflammatory activity via the inhibition of nitric oxide production in lipopolysaccharide-induced murine macrophage RAW 264. Read More

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http://dx.doi.org/10.1055/a-1192-6225DOI Listing

Clinicopathological Relevance and Prognostic Value of Androgen Receptor in Mammary Paget's Disease with Underlying Invasive Ductal Carcinoma.

Oncol Res Treat 2020 Jul 9:1-7. Epub 2020 Jul 9.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Mammary Paget's disease (MPD) is a rare cutaneous manifestation. Epidemiologically, more than half of the MPD patients concurrently have underlying invasive ductal carcinoma (MPD-IDC), and their prognosis remains poor despite multimodal treatments of breast cancer have markedly improved patients' survival. Accordingly, it is crucial to seek out novel therapeutic targets of MPD-IDC. Read More

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http://dx.doi.org/10.1159/000507893DOI Listing

Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations.

Ann Nutr Metab 2020 Jul 9:1-12. Epub 2020 Jul 9.

Public Health and Preventive Medicine Teaching and Research Center, Henan University of Chinese Medicine, Zhengzhou, China,

Background: The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. Read More

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http://dx.doi.org/10.1159/000507418DOI Listing

Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou Imaging Study.

Aging (Albany NY) 2020 Jul 9;12. Epub 2020 Jul 9.

State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.

Metabolomics provides a promising tool for understanding the pathophysiology and identifying biomarkers of atherosclerosis. We aimed to estimate the associations between circulating metabolites and subclinical atherosclerosis in a Chinese cohort. The baseline serum levels of 38 metabolites of 489 individuals were measured using nuclear magnetic resonance. Read More

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http://dx.doi.org/10.18632/aging.103456DOI Listing

Development of a specific isothermal nucleic acid amplification for the rapid and sensitive detection of shrimp allergens in processed food.

Food Chem 2020 Jun 24;332:127389. Epub 2020 Jun 24.

China Medical University, Department of Chinese Pharmaceutical Science and Chinese Medicine Resources, Taichung 40402, Taiwan. Electronic address:

Food allergens that cause anaphylactic reactions have become an important health problem worldwide. Among them, shrimp is a popular seafood in many cuisines. The best way to avoid allergic reactions is to mitigate the intake of food allergens. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127389DOI Listing

Dynamics of microbial communities, texture and flavor in Suan zuo yu during fermentation.

Food Chem 2020 Jun 18;332:127364. Epub 2020 Jun 18.

School of Food Science and Technology, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China. Electronic address:

Suan zuo yu is a traditional Chinese fermented product. We explored the microbial diversity, the dynamic changes of texture and flavor compounds at different fermentation times (up to 24 d). Results showed that Weissella and Lactobacillus may play a vital role in fermentation especially for the flavor. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127364DOI Listing

DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation.

Int Immunopharmacol 2020 Jul 6;86:106729. Epub 2020 Jul 6.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:

Oxidative stress and neuroinflammation have been deeply associated with Alzheimer's disease. DL0410 is a novel acetylcholinesterase inhibitor with potential anti-oxidative effects in AD-related animal models, while the specific mechanism has not been fully clarified. In this study, DL0410 was predicted to be related to the modification of cell apoptosis, oxidation-reduction process, inflammatory response and ERK1/ERK2 cascade by in silico target fishing and GO enrichment analysis. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106729DOI Listing

Difficulties in identifying and describing feelings, social constraints, affect, and functional well-being among Chinese breast cancer patients: A mediation model.

Eur J Oncol Nurs 2020 Apr 10;47:101760. Epub 2020 Apr 10.

Department of Medical Nursing, Weifang Medical University, China. Electronic address:

Purpose: Functional well-being (i.e., individuals' functioning in daily living activities and social roles; FWB) is often an understudied aspect of quality of life among breast cancer patients (BCP). Read More

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http://dx.doi.org/10.1016/j.ejon.2020.101760DOI Listing

Evolution of phytotoxicity during the active phase of co-composting of chicken manure, tobacco powder and mushroom substrate.

Waste Manag 2020 Jul 6;114:25-32. Epub 2020 Jul 6.

Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Science, China Agricultural University, Beijing 100193, China. Electronic address:

This study systematically investigated the phytotoxicity of chicken manure co-composted with tobacco powder and mushroom substrate on seed germination during active phase of composting. All compost products met the sanitation requirements specified in the Chinese national standard; however, only the mushroom substrate compost satisfied the maturity standard. From day 28, the composting entered the end of active phase and the concentrations of K, Zn, Na, Cu and Fe decreased gradually. Read More

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http://dx.doi.org/10.1016/j.wasman.2020.06.034DOI Listing

Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis.

Aquat Toxicol 2020 Jun 30;226:105557. Epub 2020 Jun 30.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Extensive studies have shown that estrogenic endocrine-disrupting chemicals (EDCs) can disrupt testis differentiation and even cause feminization in vertebrates. However, little is known about the mechanisms by which estrogenic EDCs disrupt testis differentiation. Here, we employed Xenopus laevis, a model amphibian species sensitive to estrogenic EDCs, to explore the molecular and cellular events by which 17β-estradiol (E2) disrupts testis differentiation and causes feminization. Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105557DOI Listing

Axillary accessory breast cancer with persistent leftsuperior vena cava: A case report and treatment controversy.

Int J Surg Case Rep 2020 Jun 20;73:71-74. Epub 2020 Jun 20.

Wuxi Higher Health Vocational Technology School, Wuxi, China. Electronic address:

Introduction: Axillary accessory breast cancer and persistent left superior vena cava (PLSVC) are rare clinically. Many controversial treatments for accessory breast cancer are worth discussing and learning.

Presentation Of The Case: A 48-year-old woman presented with biopsy histopathology confirmed. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.038DOI Listing

PsbHLH1, a novel transcription factor involved in regulating anthocyanin biosynthesis in tree peony (Paeonia suffruticosa).

Plant Physiol Biochem 2020 Jun 12;154:396-408. Epub 2020 Jun 12.

Key Laboratory of Tree Breeding and Cultivation of National Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China. Electronic address:

Flower color is one of the most important features of ornamental plants. Anthocyanin composition and concentration are usually closely related to flower color formation. The biosynthesis of anthocyanin is regulated by a series of structural genes and regulatory genes. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.06.015DOI Listing

Effect of wet sea buckthorn pomace utilized as an additive on silage fermentation profile and bacterial community composition of alfalfa.

Bioresour Technol 2020 Jul 1;314:123773. Epub 2020 Jul 1.

Grassland Research Institute, Chinese Academy of Agricultural Sciences, Hohhot 010010, China. Electronic address:

To effectively preserve nutrients, alfalfa silage was treated without (control) or with Lactobacillus plantarum (LP) and their mixture (LP + SBP). Results showed that SBP decreased (P < 0.05) final pH value and ammonia-N of total N, increased (P < 0. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123773DOI Listing

Efficacy and safety of videolaryngoscopy versus direct laryngoscopy in paediatric intubation: A meta-analysis of 27 randomized controlled trials.

J Clin Anesth 2020 Jul 6;66:109968. Epub 2020 Jul 6.

Department of Anesthesiology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Embryo Original Disease; Shanghai Municipal Key Clinical Specialty, Shanghai 200030, China. Electronic address:

Objective: Anatomical and physiological differences in paediatric and adult airways make intubation of paediatric patients a challenge. This study aimed to compare the efficacy and safety of video laryngoscopy (VL) to direct laryngoscopy (DL) on intubation outcomes in paediatric patients.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jclinane.2020.109968DOI Listing

All about toxoplasmosis in cats: the last decade.

Vet Parasitol 2020 May 27;283:109145. Epub 2020 May 27.

Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845, USA.

Toxoplasma gondii infections are common in humans and animals worldwide. Toxoplasmosis continues to be of public health concern. Cats (domestic and wild felids) are the most important host in the epidemiology of toxoplasmosis because they are the only species that can excrete the environmentally resistant oocysts in feces. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109145DOI Listing

Prevention and control of COVID-19 in nursing homes, orphanages, and prisons.

Environ Pollut 2020 Jul 2;266(Pt 1):115161. Epub 2020 Jul 2.

China CDC Key Laboratory of Environment and Population Health National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100021, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China. Electronic address:

As the number of Coronavirus Disease (2019) (COVID-19) cases increase globally, countries are taking more aggressive preventive measures against this pandemic. Transmission routes of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) include droplet and contact transmissions. There are also evidence of transmission through aerosol generating procedures (AGP) in specific circumstances and settings. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115161DOI Listing

SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection.

Mol Immunol 2020 Jul 6;125:51-62. Epub 2020 Jul 6.

Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether deletion of Socs3 in the lung epithelial cells would affect influenza lung replication and inflammation in vivo is unknown. To test this, we approached the influenza infected Socs3 and SpcCre. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.022DOI Listing

A combined abiotic oxidation-precipitation process for rapid As removal from high-As(III)-Mn(II) acid mine drainage and low As-leaching solid products.

J Hazard Mater 2020 Jul 1;401:123360. Epub 2020 Jul 1.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, China. Electronic address:

A combination process of Fenton-like and catalytic Mn(II) oxidation via molecular oxygen-induced abio-oxidation of As(III)-Mn(II)-rich acid mine drainage (AMD) is developed to rapidly and efficiently remove As and obtain low As-leaching solids in this study. The effect of pH, temperature, oxygen flow rate and neutralization reagent on As removal was investigated. The results showed that pH was important to As removal efficiency, which achieved maximum in 0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123360DOI Listing

Ultra-stable aqueous foams induced by interfacial co-assembly of highly hydrophobic particles and hydrophilic polymer.

J Colloid Interface Sci 2020 Jun 26;579:628-636. Epub 2020 Jun 26.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. Electronic address:

Hypothesis: Interfacial assembly between nanoparticles and complementary ligands can in-situ generate Janus-like particles, rendering high stability of a Pickering-based system. Hence, through the self-assembly and formation of a Janus structure at the air/water interface, which is composed of a hydrophobic particle layer in the inner air phase and then a hydrophilic polymer layer in the aqueous phase, it should be possible to fabricate ultra-stable Pickering foams.

Experiments: Foams containing different highly hydrophobic particles and hydrophilic polymers or microgels were prepared, and their stability was investigated. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.098DOI Listing

Analysis of relapse-associated alternative mRNA splicing and construction of a prognostic signature predicting relapse in I-III colon cancer.

Genomics 2020 Jul 6. Epub 2020 Jul 6.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

The literature comprehensively analyzed alternative splicing (AS) events in colon cancer is little and corresponding prognostic signature is still a lack. Based on data of TCGA, the relapse-associated ASs were comprehensively analyzed and a signature was further constructed to predict the relapse in I-III colon cancer. In total 1912 ASs of 1384 mRNA were identified as relapse-associated ASs, protein-protein interactions (PPI) and ASs-splicing factors (SF) interactions network were identified. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.07.002DOI Listing

Shaping children's racial bias through interpersonal movement.

J Exp Child Psychol 2020 Jul 6;198:104884. Epub 2020 Jul 6.

Department of Psychology, University of Toronto Scarborough, Scarborough, Ontario M1C 1A4, Canada. Electronic address:

The early emergence of racial biases points to the urgent need to understand how interpersonal experiences might shape them. We examined whether interpersonal movement shapes racial biases among 4- to 6-year-old Chinese children who had no prior contact with Black people. In Experiment 1 (N = 134), children played a musical game, moving either in or out of synchrony with a Chinese or Black adult. Read More

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http://dx.doi.org/10.1016/j.jecp.2020.104884DOI Listing

Cloning and characterization of Litopenaeus vannamei cystainB-like in WSSV infection.

Fish Shellfish Immunol 2020 Jul 6. Epub 2020 Jul 6.

Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, China. Electronic address:

Cystatins B is an endogenous cysteine cathepsin inhibitor. In shrimp, cystatins B-like (CSTB-L) has not been characterized and its role in WSSV infection is largely unknown. In this study, a full-length 699 bp CSTB-L sequence with 291 bp open reading frame encoding a 96 amino acid from L. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.07.008DOI Listing

Structural features and antioxidant behavior of lignins successively extracted from ginkgo shells (Ginkgo biloba L).

Int J Biol Macromol 2020 Jul 6. Epub 2020 Jul 6.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Ginkgo shells as by-products from Ginkgo biloba L. industries with a remarkable annual output up to now are not fully analyzed and exploited. For the application of ginkgo shells beyond their current roles, structure and antioxidant activity of milled wood lignins successively extracted from two ginkgo shell species were investigated. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.027DOI Listing

Combining environmental isotopes with Contaminants of Emerging Concern (CECs) to characterise wastewater derived impacts on groundwater quality.

Water Res 2020 Jun 12;182:116036. Epub 2020 Jun 12.

School of Engineering, RMIT University, GPO Box 2476, Melbourne, VIC, 3001, Australia; Water: Effective Technologies & Tools Research Centre, RMIT University, GPO Box 2476, Melbourne, VIC, 3001, Australia. Electronic address:

The potential for Wastewater Treatment Plants (WWTPs) to cause adverse impacts to groundwater quality is a major global environmental challenge. Robust and sensitive techniques are required to characterise these impacts, particularly in settings with multiple potential contaminant sources (e.g. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116036DOI Listing

Molecular pathogenesis of the hyaluronic acid capsule of Pasteurella multocida.

Microb Pathog 2020 Jul 6:104380. Epub 2020 Jul 6.

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China; Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China. Electronic address:

Pasteurella multocida possesses a viscous capsule polysaccharide on the cell surface, which is a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. Based on the capsular antigen, P. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104380DOI Listing

Pathogenicity of Aeromonas hydrophila causing mass mortalities of Procambarus clarkia and its induced host immune response.

Microb Pathog 2020 Jul 6:104376. Epub 2020 Jul 6.

College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. Electronic address:

Outbreaks of mass mortalities among cultured Procambarus clarkia occurred in a commercial hatchery during the spring of 2019 in Jiangsu province of China. Here, we exploit the pathogenicity and immune response of Aeromonas hydrophila (GPC1-2), which was isolated from diseased P. clarkia. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104376DOI Listing

Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU.

Clin Chim Acta 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address:

Background: The novel SARS-CoV-2 caused a large number of infections and deaths worldwide. Thus, new ideas for an appropriated assessment of patients' condition and clinical treatment are of utmost importance. Therefore, in this study, the laboratory parameters of patients with coronavirus disease 2019 (COVID-19) were evaluated to identify the correlation between cytokine expression and other laboratory parameters. Read More

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http://dx.doi.org/10.1016/j.cca.2020.07.002DOI Listing

"One-gate" design should be used for the study of the diagnostic efficacy of biological markers.

Clin Chim Acta 2020 Jul 6. Epub 2020 Jul 6.

Department of Laboratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese, Medicine, Jinan 250014, China. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2020.07.004DOI Listing

Fine-tuning ERNIE for Chest Abnormal Imaging Signs Extraction.

J Biomed Inform 2020 Jul 6:103492. Epub 2020 Jul 6.

School of Data and Computer Science, Guangdong Province Key Lab of Computational Science, Sun Yat-Sen University, Guangzhou, Guangdong 510006, PR China. Electronic address:

Chest imaging reports describe the results of chest radiography procedures. Automatic extraction of abnormal imaging signs from chest imaging reports has a pivotal role in clinical research and a wide range of downstream medical tasks. However, there are few studies on information extraction from Chinese chest imaging reports. Read More

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http://dx.doi.org/10.1016/j.jbi.2020.103492DOI Listing

RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins.

Mol Cell 2020 Jun 30. Epub 2020 Jun 30.

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Road, Pudong New District, Shanghai 201203, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China. Electronic address:

Valosin-containing protein (VCP)/p97 is an AAA-ATPase that extracts polyubiquitinated substrates from multimeric macromolecular complexes and biological membranes for proteasomal degradation. During p97-mediated extraction, the substrate is largely deubiquitinated as it is threaded through the p97 central pore. How p97-extracted substrates are targeted to the proteasome with few or no ubiquitins is unknown. Read More

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http://dx.doi.org/10.1016/j.molcel.2020.06.023DOI Listing

Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.

Eur J Pharmacol 2020 Jul 6:173352. Epub 2020 Jul 6.

Department of Chinese Medicinal Pharmaceutics, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Yang Guang South Street, Fangshan District, Beijing, 102488, China. Electronic address:

Pulmonary fibrosis (PF) is an interstitial lung disease characterized by interstitial inflammation and fibrosis. Salvianolic acid B (SAB) and sodium tanshinone IIA sulfonate (STS) are representative components in Salvia miltiorrhiza, which have been reported using in the treatment of PF. The aim of the study was to explain the role of inflammation in the process of PF and to investigate the effect of SAB and STS on inflammation and fibrosis in vitro. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173352DOI Listing

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS.

Cell 2020 Jun 28. Epub 2020 Jun 28.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 101408, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor-binding domain (RBD) is an attractive vaccine target but is undermined by limited immunogenicity. We describe a dimeric form of MERS-CoV RBD that overcomes this limitation. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.035DOI Listing

Genome Editing Enables Next-Generation Hybrid Seed Production Technology.

Mol Plant 2020 Jul 6. Epub 2020 Jul 6.

Institute of Crop Science, Chinese Academy of Agricultural Sciences, National Key Facility for Crop Gene Resources and Genetic Improvement, Beijing 100081, China. Electronic address:

The next-generation hybrid seed technology enables the successful production of sortable hybrid seeds from genic male sterile (GMS) lines and maintainers; however, it requires multiple laborious and complicated steps. Here, we designed a simple next-generation hybrid seed production strategy that takes advantage of the CRISPR/Cas9 technology to create a Manipulated GMS Maintainer (MGM) system via a single transformation. Under this schema, the maize male fertility gene ZmMS26 was nullified by removal of its fifth exon using the CRISPR/Cas9 system on a vector, and a second vector carrying a functional ZmMS26 cDNA was co-transformed to restore fertility. Read More

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http://dx.doi.org/10.1016/j.molp.2020.06.003DOI Listing

The COVID-19 pandemic.

Crit Rev Clin Lab Sci 2020 Jul 9:1-24. Epub 2020 Jul 9.

Department of Experimental Medicine, University of Tor Vergata, Rome, Italy.

In December 2019, an outbreak of pneumonia of unknown origin was reported in Wuhan, Hubei Province, China. Pneumonia cases were epidemiologically linked to the Huanan Seafood Wholesale Market. Inoculation of respiratory samples into human airway epithelial cells, Vero E6 and Huh7 cell lines, led to the isolation of a novel respiratory virus whose genome analysis showed it to be a novel coronavirus related to SARS-CoV, and therefore named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

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http://dx.doi.org/10.1080/10408363.2020.1783198DOI Listing

Neighborhood effects on the tannin-related foraging decisions of two rodent species under semi-natural conditions.

Integr Zool 2020 Jul 9. Epub 2020 Jul 9.

Institute of Ecology and Geobotany, College of Ecology and Environmental Science, Yunnan University, Kunming, 650091, China.

Neighborhood effects on seed predation and dispersal processes are usually seed-characteristic-dependent; however, how seeds with certain characteristics affect the foraging behavior of rodents in relation to other seeds nearby is unclear. Because large differences in seed characteristics between neighboring seeds may lead to significant differences in rodent foraging preferences, we hypothesized that neighborhood effects were more likely to be detected when paired seeds differed in seed characteristics. We investigated the foraging decisions of two rodent species, the red spiny rat Maxomys surifer and the Chinese white-bellied rat Niviventer confucianus, in semi-natural enclosures by presenting them with artificial seeds containing different levels of tannin (0, 3% and 6% tannin). Read More

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http://dx.doi.org/10.1111/1749-4877.12473DOI Listing

The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness.

J Leukoc Biol 2020 Jul;108(1):189-198

Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.

Acupuncture is a centuried and unfading treatment of traditional Chinese medicine, which has been proved to exert curative effects on various disorders. Numerous works have been put in to uncover the effective mechanisms of acupuncture. And the interdependent interaction between acupuncture and acupoint microenvironment is a crucial topic. Read More

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http://dx.doi.org/10.1002/JLB.3AB0420-361RRDOI Listing

A nomogram prediction for mandibular molar survival in Chinese patients with periodontitis: a 10-year retrospective cohort study.

J Clin Periodontol 2020 Jul 9. Epub 2020 Jul 9.

Department of Periodontology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing, China.

Aims: To develop a nomogram prediction model of mandibular molar survival by comprehensively analyzing clinical and radiographic risk factors of mandibular molar loss.

Materials And Methods: 478 mandibular molars of 139 subjects who underwent non-surgical periodontal treatment were examined retrospectively within a mean follow-up period of 11.1 years. Read More

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http://dx.doi.org/10.1111/jcpe.13343DOI Listing

Root anatomical traits determined leaf-level physiology and responses to precipitation change of herbaceous species in a temperate steppe.

New Phytol 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, the Chinese Academy of Sciences, Beijing, 100093, China.

lRoot anatomy plays important roles in control of leaf water relations. However, few studies have evaluated whether and how anatomical traits of absorptive roots influence leaf physiology of herbaceous species in a temperate grassland. lWe measured absorptive root anatomical traits and leaf physiological traits of 15 herbaceous species in a temperate steppe and monitored their responses to increased precipitation in a field stimulating experiment. Read More

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http://dx.doi.org/10.1111/nph.16797DOI Listing

CsSWEET1a and CsSWEET17 Mediate Growth and Freezing Tolerance by Promoting Sugar Transport across the Plasma Membrane.

Plant Cell Physiol 2020 Jul 9. Epub 2020 Jul 9.

National Center for Tea Plant Improvement, Tea Research Institute, Chinese Academy of Agricultural Sciences; Key Laboratory of Tea Biology and Resources Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, China.

Sugars will eventually be exported transporters (SWEETs) are important in plant biological processes. Expression levels of CsSWEET1a and CsSWEET17 are induced by cold acclimation (CA) and cold stress in Camellia sinensis. Here, we found that CsSWEET17 was alternatively spliced, and its exclusion (Ex) transcript was associated with CA process. Read More

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http://dx.doi.org/10.1093/pcp/pcaa091DOI Listing

Effect of weight loss on the retinochoroidal structural alterations among patients with exogenous obesity.

PLoS One 2020 9;15(7):e0235926. Epub 2020 Jul 9.

Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Purpose: To evaluate the changes in the retinochoroidal vasculature in patients with exogenous obesity using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA).

Methods: In this prospective study, 60 patients diagnosed with obesity (47 males) (mean age: 46.47±10. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235926PLOS

Main and interacting effects of physical activity and sedentary time on older adults' BMI: The moderating roles of socio-demographic and environmental attributes.

PLoS One 2020 9;15(7):e0235833. Epub 2020 Jul 9.

Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.

Objectives: Our first aim was to examine the main and interacting effects of accelerometer-based sedentary time (ST) and moderate-to-vigorous physical activity (MVPA) with BMI and the likelihood of being overweight/obese in Hong Kong and Ghent (Belgium) older adults. Second, we examined whether these main associations and interactions between MVPA and ST were moderated by socio-demographics (gender, education) and objective neighbourhood attributes supposed to be associated with healthy food intake (food outlet density, neighbourhood-level SES). Finally, we determined whether the associations and interactions were generalisable across study sites. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235833PLOS

Research on the relationship between Urban economic development level and urban spatial structure-A case study of two Chinese cities.

PLoS One 2020 9;15(7):e0235858. Epub 2020 Jul 9.

School of Architecture and Urban Planning, Yunnan University, Yunnan, China.

The characteristics of urban spatial structure and the objective evaluation of the development level of urban economy have always been the concern of urban researchers, However, the spatial relationship between urban spatial structure and urban economic development level is often deliberately ignored. Through the point of interest (POI), the identification framework is constructed, the spatial structure of the city is identified and evaluated, and the Geographically Weighted Regression analysis is carried out with the distribution of unit GDP (Gross Domestic Product) in this study. The research shows that Kunming and Guiyang are polycentric spatial structures and Kunming's structure is more significant. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235858PLOS

Nesting and foraging behavior of Xylocopa valga in the Ejina Oasis, China.

PLoS One 2020 9;15(7):e0235769. Epub 2020 Jul 9.

Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Xylocopa valga is extinct in Latvia and Lithuania and is critically endangered in Poland, and its distribution in the Ejina Oasis, China, is currently unknown. Studies on the biology of X. valga are scarce, and thus, conservation efforts for this species are currently limited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235769PLOS

High-fidelity SaCas9 identified by directional screening in human cells.

PLoS Biol 2020 Jul 9;18(7):e3000747. Epub 2020 Jul 9.

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China.

CRISPR-Staphylococcus aureus Cas9 (CRISPR-SaCas9) has been harnessed as an effective in vivo genome-editing tool to manipulate genomes. However, off-target effects remain a major bottleneck that precludes safe and reliable applications in genome editing. Here, we characterize the off-target effects of wild-type (WT) SaCas9 at single-nucleotide (single-nt) resolution and describe a directional screening system to identify novel SaCas9 variants with desired properties in human cells. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000747DOI Listing

Validity and reliability of EQ-5D-5L among patients with axial spondyloarthritis in Singapore.

Eur J Rheumatol 2020 Apr 1;7(2):71-78. Epub 2020 Apr 1.

Department of Medicine, Duke-NUS Medical School, 8 College Road, Singapore.

Objective: This study aims to evaluate the reliability and validity of EuroQOL-5 Dimensions-5 Levels (EQ-5D-5L) among patients with axial spondyloarthritis (SpA) in Singapore.

Methods: A cross-sectional study was conducted involving patients with axial SpA in an Asian tertiary hospital from 2017 to 2018. This study followed the COnsensus-based Standards for selection of health Measurement Instruments framework. Read More

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http://dx.doi.org/10.5152/eurjrheum.2020.19043DOI Listing

DBDx-based drug combinations show highly potent therapeutic efficacy against human pancreatic cancer xenografts in athymic mice.

Cancer Biol Ther 2020 Aug 17;21(8):749-757. Epub 2020 Jun 17.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China.

Previous studies have shown that DBDx, a combination consisting of dipyridamole, bestatin and dexamethasone is highly effective against several cancer xenografts in athymic mice. Here the therapeutic effects of DBDx and its combination with gemcitabine or capcitabine against human pancreatic cancer xenografts and the mechanism were studied. In vivo experiments performed in athymic mice showed that the antitumor efficacy of DBDx was much stronger than that of gemcitabine or capecitabine alone. Read More

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http://dx.doi.org/10.1080/15384047.2020.1776580DOI Listing

A new dilignan from the twigs and leaves of .

J Asian Nat Prod Res 2020 Jul 9:1-6. Epub 2020 Jul 9.

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Previous work has shown that the lignans from the twigs and leaves of (Jack) I.C.N. Read More

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http://dx.doi.org/10.1080/10286020.2020.1791097DOI Listing

Identification of a 14-lncRNA Signature and Construction of a Prognostic Nomogram Predicting Overall Survival of Gastric Cancer.

DNA Cell Biol 2020 Jul 9. Epub 2020 Jul 9.

Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Increasing evidence suggests that aberrant long noncoding (lnc) RNA expression plays a vital role in gastric cancer (GC) initiation and progression. Thus, we aimed to develop a lncRNA-based risk signature and nomogram to predict overall survival (OS) for patients with GC. Our primary cohort was composed of 341 patients with clinical and lncRNA expression data in The Cancer Genome Atlas stomach adenocarcinoma (TCGA STAD), the internal validation cohort was composed of 172 randomly assigned patients, and the external validation cohort was composed of 300 patients from GSE62254 dataset. Read More

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http://dx.doi.org/10.1089/dna.2020.5565DOI Listing
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