1,206 results match your criteria Chinese Journal Of Physiology[Journal]


Effects of (L.) millsp. roots extracts on the antioxidant and anti-inflammatory activities.

Chin J Physiol 2020 May-Jun;63(3):137-148

Department of Food Science and Biotechnology, College of Biotechnology and Bioresources, Da-Yeh University, Changhua, Taiwan.

Cajanus cajan (L.) Millsp., also named pigeon pea, is widely grown in the tropics and the subtropics. Read More

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http://dx.doi.org/10.4103/CJP.CJP_88_19DOI Listing

Glucose reduces the osmopressor response in connection with the tyrosine phosphorylation of focal adhesion kinase in red blood cells.

Chin J Physiol 2020 May-Jun;63(3):128-136

Department of Anesthesiology, Taipei Veterans General Hospital; Graduate Institute of Life Sciences, National Defense Medical Center; Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.

Glucose ingestion attenuates the water ingestion-induced increase in the total peripheral vascular resistance and orthostatic tolerance. We investigated the gastrointestinal physiology of glucose by examining the effect of glucose ingestion on the functional expression of focal adhesion kinase (FAK) in red blood cell (RBC) membrane. This study was performed in 24 young, healthy subjects. Read More

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http://dx.doi.org/10.4103/CJP.CJP_32_20DOI Listing

Resveratrol enhances therapeutic effect on pancreatic regeneration in diabetes mellitus rats receiving autologous transplantation of adipose-derived stem cells.

Chin J Physiol 2020 May-Jun;63(3):122-127

Cardiovascular and Mitochondrial Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien; Department of Medical Research, China Medical University Hospital, China Medical University; Department of Biotechnology, Asia University, Taichung, Taiwan.

Pancreatic damage is the major causative agent in type 1 diabetes mellitus (DM). Several strategies have been suggested to regenerate pancreatic functions, such as stem cell transplantation and administration of active components isolating from natural herbals. This study aims to investigate if the synergistically protective effect on damaged pancreatic tissues can be observed in STZ-induced DM rats with autologous transplantation of adipose-derived stem cells (ADSC) coupling with oral administration of resveratrol. Read More

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http://dx.doi.org/10.4103/CJP.CJP_3_20DOI Listing

Muscle type from which satellite cells are derived plays a role in their damage response.

Chin J Physiol 2020 May-Jun;63(3):113-121

Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.

The aim of this study was to evaluate the response of satellite cells to muscular atrophies which possess different pathological characteristics and which were induced by distinct damages. Right lower limbs of rats were exposed to denervation or disuse and later its tibialis anterior (TA) or soleus (SOL) muscles were analyzed. After confirming their functional impairments indicated by common but distinct pathological and electrophysiological characteristics, the quantitative polymerase chain reaction analysis of Pax7 and Pax3 expressions and the number of Pax7 and Pax3 cells were analyzed sequentially at day 0, day 7, and day 14. Read More

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http://dx.doi.org/10.4103/CJP.CJP_98_19DOI Listing

Combination of exercise training and resveratrol attenuates obese sarcopenia in skeletal muscle atrophy.

Chin J Physiol 2020 May-Jun;63(3):101-112

Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Obese sarcopenia is a progressive loss of skeletal muscle mass and strength with increases in adipocytes. The aim of this study was to investigate the effects of combination of exercise training and resveratrol on the pathological pathway from obesity to sarcopenia, and potential therapy for skeletal muscle declines in physical function. Two animal models were experimented: (1) C57BL/6J male mice were fed either a high-fat diet (HFD) for 8 weeks to induce obesity and resveratrol (low-, middle-, and high-dose) for 4 weeks. Read More

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http://dx.doi.org/10.4103/CJP.CJP_95_19DOI Listing

Physiological and pathological functions of beta-amyloid in the brain and alzheimer's disease: A review.

Authors:
Ladislav Volicer

Chin J Physiol 2020 May-Jun;63(3):95-100

School of Aging Studies, University of South Florida, Tampa, FL, USA; 3rd Medical Faculty, Charles University, Prague, Czech Republic, Europe.

Alzheimer's disease is a major health problem all over the world. The role of beta-amyloid (Aβ) is at the center of investigations trying to discover the disease pathogenesis and to develop drugs for treatment or prevention on Alzheimer's disease. This review summarizes both physiological and pathological functions of Aβ and factors that may participate in the disease development. Read More

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http://dx.doi.org/10.4103/CJP.CJP_10_20DOI Listing

The expression and significance of serum caveolin-1 in patients with Kawasaki disease.

Chin J Physiol 2020 Mar-Apr;63(2):90-94

Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Institute of Cardiovascular Development and Translational Medicine, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.

We investigated the expression of caveolin-1 (Cav-1) in Kawasaki disease (KD) and analyzed its relationship with coronary artery lesions (CALs). Cav-1 participated in the progression of CAL in KD. A total of 68 children with KD (23 with CALs), age matched with a fever control group (F, n = 28) and a normal control group (N, n = 24) were enrolled in this study. Read More

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http://dx.doi.org/10.4103/CJP.CJP_71_19DOI Listing

Muscle activation and intermuscular coherence during forward and backward pedaling.

Chin J Physiol 2020 Mar-Apr;63(2):85-89

Department of Physical Therapy and Assistive Technology, National Yang-Ming University; Preventive Medicine Research Center, National Yang-Ming University, Taipei, Taiwan.

The purpose of this study was to investigate muscle activity and intermuscular coherence of the rectus femoris (RF) and biceps femoris (BF) during forward (FW) and backward (BW) pedaling. Sixteen healthy volunteers performed FW and BW pedaling in 30, 45, and 60 revolutions per minute (RPM), while electromyographic (EMG) signals of the RF and BF were recorded bilaterally to determine integral EMG and intermuscular coherence. BW pedaling showed a statistically significant larger EMG activity on the left BF (P = 0. Read More

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http://dx.doi.org/10.4103/CJP.CJP_82_19DOI Listing

extract reduces hepatotoxicity by antioxidative properties following dichlorvos administration in rats.

Chin J Physiol 2020 Mar-Apr;63(2):77-84

Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Ipomoea aquatica (IA) with antioxidant properties is used in therapeutic trends. An organophosphate, dichlorvos (Dich), is a common insecticide with various side effects on living tissues. This study examines the role of IA on Dich-induced hepatotoxicity in male rats. Read More

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http://dx.doi.org/10.4103/CJP.CJP_89_19DOI Listing

Repetitively hypoxic preconditioning attenuates ischemia/reperfusion-induced liver dysfunction through upregulation of hypoxia-induced factor-1 alpha-dependent mitochondrial Bcl-xl in rat.

Chin J Physiol 2020 Mar-Apr;63(2):68-76

School of Life Science, National Taiwan Normal University, Taipei, Taiwan.

Repetitive hypoxic preconditioning (HP) enforces protective effects to subsequently severe hypoxic/ischemic stress. We hypothesized that HP may provide protection against ischemia/reperfusion (I/R) injury in rat livers via hypoxia-induced factor-1 alpha (HIF-1α)/reactive oxygen species (ROS)-dependent defensive mechanisms. Female Wistar rats were exposed to hypoxia (15 h/day) in a hypobaric hypoxic chamber (5500 m) for HP induction, whereas the others were kept in sea level. Read More

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http://dx.doi.org/10.4103/CJP.CJP_74_19DOI Listing

Investigation of effect of tectorigenin (O-methylated isoflavone) on Ca signal transduction and cytotoxic responses in canine renal tubular cells.

Chin J Physiol 2020 Mar-Apr;63(2):60-67

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Tectorigenin, a traditional Chinese medicine, is isolated from the flower of plants such as Pueraria thomsonii Benth. It is an O-methylated isoflavone, a type of flavonoid. Previous studies have shown that tectorigenin evoked various physiological responses in different models, but the effect of tectorigenin on cytosolic-free Ca levels ([Ca]) and cytotoxicity in renal tubular cells is unknown. Read More

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http://dx.doi.org/10.4103/CJP.CJP_14_20DOI Listing

Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress.

Chin J Physiol 2020 Mar-Apr;63(2):53-59

Division of Medical Research and Education, Cheng Hsin General Hospital, Taipei, Taiwan.

Water-induced pressor response appears mediated through the activation of transient receptor potential channel TRPV4 on hepatic portal circulation in animals. We sought to elucidate the mechanism of portal vein signaling in this response. Forty-five rats were divided into four groups: control rats without water ingestion (WI), control rats with WI, portal vein denervation rats with WI (PVDWI), and TRPV4 antagonist-treated rats with WI (anti-TRPV4WI). Read More

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http://dx.doi.org/10.4103/CJP.CJP_96_19DOI Listing

Corrigendum: Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats.

Authors:

Chin J Physiol 2020 Jan-Feb;63(1):50

[This corrects the article DOI: 10.4103/CJP.CJP_61_19]. Read More

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http://dx.doi.org/10.4103/0304-4920.277957DOI Listing
February 2020

The role of genotype/phenotype at apurinic/apyrimidinic endonuclease Rs1130409 in renal cell carcinoma.

Chin J Physiol 2020 Jan-Feb;63(1):43-49

Graduate Institute of Biomedical Sciences, China Medical University; Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.

The DNA repair capacity plays a critical role in maintaining the genomic stability and gatekeeping for individual cancer risk. In this study, we aim at evaluation the role of the AspGlu (rs1130409) variant at apurinic/apyrimidinic endonuclease (APE) gene in renal cell carcinoma (RCC) risk and the contribution of different genotypes to its transcriptional mRNA levels. In the case-control study, 92 RCC patients and 580 cancer-free patients matched by age and gender were recruited. Read More

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http://dx.doi.org/10.4103/CJP.CJP_72_19DOI Listing
February 2020
1.275 Impact Factor

Beneficial effects of a negative ion patch on eccentric exercise-induced muscle damage, inflammation, and exercise performance in badminton athletes.

Chin J Physiol 2020 Jan-Feb;63(1):35-42

Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Complementary and alternative medicines (CAMs) are widely applied and accepted for therapeutic purposes because of their numerous benefits. Negative ion treatment belongs to one of the critical categories defined by the National Center for CAM, with such treatment capable of air purification and ameliorating emotional disorders (e.g. Read More

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http://dx.doi.org/10.4103/CJP.CJP_33_19DOI Listing
February 2020
1.275 Impact Factor

Formosan wood mice () exhibit more exploratory behaviors and central dopaminergic activities than C57BL/6 mice in the open field test.

Chin J Physiol 2020 Jan-Feb;63(1):27-34

Holistic Education Center, Tzu Chi University of Science and Technology, Hualien, Taiwan.

Three-quarters of the lands in Taiwan are over 1000 m above sea level. Formosan wood mice (Apodemus semotus), also called Taiwanese field mice, are largely found at altitudes of 1400 ~ 3700 m and are the dominant rodents in these areas. Notably, Formosan wood mice show high levels of exploratory behaviors, not only in the wild but also in laboratory situations. Read More

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http://dx.doi.org/10.4103/CJP.CJP_47_19DOI Listing
February 2020

Acute and chronic effects of aerobic exercise on serum irisin, adropin, and cholesterol levels in the winter season: Indoor training versus outdoor training.

Chin J Physiol 2020 Jan-Feb;63(1):21-26

Department of Medical Biochemistry, School of Medicine, University of Health Sciences, Istanbul, Turkey.

The aim of this study is to investigate the acute and chronic effects of aerobic training performed indoors and outdoors on irisin, adropin, and cholesterol levels in winter. Thirty-two healthy males participated in this study. Participants were divided into two groups: outdoor group (n = 16) and indoor group (n = 16). Read More

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http://dx.doi.org/10.4103/CJP.CJP_84_19DOI Listing
February 2020

Physiological stress against simulated 200-m and 500-m sprints in world-class boat paddlers.

Chin J Physiol 2020 Jan-Feb;63(1):15-20

Institute of Sports Sciences, Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.

To characterize physiological stress response against simulated short-distance sprints among world-class paddlers. Thirteen dragon boat gold medalists performed 200-m and 500-m simulated race trials on a kayak ergometer in a randomized, counter-balanced, crossover fashion. During the 200-m and 500-m sprints, oxygen consumption (VO) increased from 8. Read More

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http://dx.doi.org/10.4103/CJP.CJP_87_19DOI Listing
February 2020
1.275 Impact Factor

Distinct patterns of interleukin-12/23 and tumor necrosis factor α synthesis by activated macrophages are modulated by glucose and colon cancer metabolites.

Chin J Physiol 2020 Jan-Feb;63(1):7-14

Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.

Chronic inflammation is a major risk factor for colitis-associated colorectal carcinoma (CRC). Macrophages play a key role in altering the tumor microenvironment by producing pro-inflammatory and anti-inflammatory cytokines. Our previous studies showed that glucose metabolism conferred death resistance for tumor progression and exerted anti-inflammatory effects in ischemic gut mucosa. Read More

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http://dx.doi.org/10.4103/CJP.CJP_75_19DOI Listing
February 2020

Sex-related differences in sudomotor function in healthy early twenties focused on activated sweat gland density.

Chin J Physiol 2020 Jan-Feb;63(1):1-6

College of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

The purpose of this study was to quantitatively assess the difference in sudomotor function between healthy males and females in their early twenties by measuring skin surface area and activated sweat gland density (ASGD). The quantitative sudomotor axon reflex test (QSART), a method for evaluating autonomic nervous system activity, was used for quantification. In QSART, the sweat glands are activated directly or indirectly by the subcutaneous application of neurotransmitters, such as acetylcholine, through iontophoresis. Read More

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http://dx.doi.org/10.4103/CJP.CJP_46_19DOI Listing
February 2020
1.275 Impact Factor

Corrigendum: Action of citral on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in juvenile mice.

Authors:

Chin J Physiol 2019 Nov-Dec;62(6):285

[This corrects the article DOI: 10.4103/CJP.CJP_32_19]. Read More

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http://dx.doi.org/10.4103/0304-4920.272031DOI Listing
December 2019

Blood dopamine level enhanced by caffeine in men after treadmill running.

Chin J Physiol 2019 Nov-Dec;62(6):279-284

Department of Physiology, College of Medicine, Soonchunhyang University, Dongnam-Gu, Cheonan, Korea.

The aim of this study was to investigate the plasma dopamine and serum serotonin levels in humans with and without caffeine (CAFF) ingestion during treadmill running exercise. Thirty male volunteers participated in the randomized experiment involving two groups: CON (n = 15, 200 mL of tap water) versus CAFF (n = 15, 3 mg/kg CAFF and 200 mL tap water). After treadmill running, the dopamine level was significantly increased in the CAFF group (P < 0. Read More

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http://dx.doi.org/10.4103/CJP.CJP_59_19DOI Listing
December 2019

The impact of high-intensity laser therapy on oxidative stress, lysosomal enzymes, and protease inhibitor in athletes.

Chin J Physiol 2019 Nov-Dec;62(6):273-278

Department of Psychiatry, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, Bydgoszcz, Poland.

The aim of the study was to assess the effect of one session of high-intensity laser therapy (HILT) on the levels of selected oxidative stress parameters, lysosomal hydrolases, and anti-inflammatory serine protease inhibitor in the peripheral blood of amateur athletes with torn or pulled tendons of the ankle or the knee joint. The group of injured athletes comprised 16 males and females aged 16.3 ± 1. Read More

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http://dx.doi.org/10.4103/CJP.CJP_40_19DOI Listing
December 2019

Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats.

Chin J Physiol 2019 Nov-Dec;62(6):267-272

Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.

Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo. Here, we examined glucose and insulin responses after an oral glucose challenge (0. Read More

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http://dx.doi.org/10.4103/CJP.CJP_61_19DOI Listing
December 2019
1.275 Impact Factor

Sex Differences in antiaging response to short- and long-term high-intensity interval exercise in rat cardiac muscle: Telomerase activity, total antioxidant/oxidant status.

Chin J Physiol 2019 Nov-Dec;62(6):261-266

Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.

Cardiovascular disease prevails with age which varies according to sex. Telomere length plays an important role in aging. Despite the great benefits of high-intensity interval training (HIIT), the acute responses to HIIT with different intervals have not been elucidated in different sexes. Read More

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http://dx.doi.org/10.4103/CJP.CJP_52_19DOI Listing
December 2019

Changes in the microvasculature and hemostatic system in rats after insonation.

Chin J Physiol 2019 Nov-Dec;62(6):256-260

Department of Normal Physiology, Federal State Budgetary Educational Institution of Higher Education "Altai State Medical University" of the Ministry of Health of the Russian Federation, Barnaul, Altai Territory; Laboratory of Physiology and Pathology of Hemostasis and Hemodynamics, Federal State Budgetary Scientific Institution "Scientific-Research Institute of Physiology and Basic Medicine", Novosibirsk, Russia.

Ultrasound, one of the most physically impactful factors of the modern human living environment, can cause hemodynamic changes in the microvasculature and the hemostatic system. Such shifts can be considered as possible predictors of cardiovascular diseases and their complications. This study aimed to examine the effect of 7-day in-air insonation on the microvasculature and hemostatic system of rats. Read More

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http://dx.doi.org/10.4103/CJP.CJP_9_19DOI Listing
December 2019

Sex differences and the modulating effects of gonad intactness on behavioral conformity in a mouse model.

Chin J Physiol 2019 Nov-Dec;62(6):245-255

Department of Physiology; Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.

Although gender differences in conformity are noticed in human studies, cultural norms and psychosocial factors inevitably affect such differences. Biological factors, especially the gonadal hormones and the brain regions involved, contributing to the sex differences in behavioral conformity remained scarcely explored. To prevent psychosocial and cultural norm confounds, intact and gonadectomized male and female mice were used to assess the modulating effects of gonadal hormones on behavioral conformity and such conformity-related brain regions using an approach of choice paradigm. Read More

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http://dx.doi.org/10.4103/CJP.CJP_42_19DOI Listing
December 2019

Identification of the force-velocity curve on dynamic resistance exercise for rats.

Chin J Physiol 2019 Nov-Dec;62(6):241-244

Research in Exercise and Nutrition in Health and Sports Performance-PENSARE, Graduate Program in Movement Sciences; Graduate Program in Health and Development in the Midwest Region, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.

The aim of this study was to identify force-velocity and power-velocity curves in climbing activity protocols, used as dynamic resistance exercise in rats. Eighteen 45-day-old male Wistar rats (weight = 211.9 ± 5. Read More

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http://dx.doi.org/10.4103/CJP.CJP_49_19DOI Listing
December 2019

Mechanistic insight of cyclin-dependent kinase 5 in modulating lung cancer growth.

Chin J Physiol 2019 Nov-Dec;62(6):231-240

Department of Nursing, Asia University; Translational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase in the central nervous system, has raised much attention in the recent years. Patients with aberrant Cdk5 expression also lead to poor survival. Read More

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http://dx.doi.org/10.4103/CJP.CJP_67_19DOI Listing
December 2019

Lifetime overproduction of circulating angiotensin-(1-7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise.

Chin J Physiol 2019 Sep-Oct;62(5):226-230

Department of Physiology and Pharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Angiotensin-(1-7) (Ang-[1-7]) can modulate glucose metabolism and protect against muscular damage. The aim of this study was to investigate the influence of lifetime increase of circulating levels of Ang-(1-7) at exhaustive swimming exercise (ESE). Sprague-Dawley (SD) and transgenic rats TGR(A1-7)3292 (TR) which overproduce Ang-(1-7) (2. Read More

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http://dx.doi.org/10.4103/CJP.CJP_57_19DOI Listing
November 2019

Association between adiposity and fasting serum levels of appetite-regulating peptides: Leptin, neuropeptide Y, desacyl ghrelin, peptide YY(1-36), obestatin, cocaine and amphetamine-regulated transcript, and agouti-related protein in nonobese participants.

Chin J Physiol 2019 Sep-Oct;62(5):217-225

Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Łódź, Poland.

The objective of this study was to evaluate the association between adiposity parameters and fasting serum levels of appetite-regulating peptides: leptin, neuropeptide Y (NPY), desacyl ghrelin, peptide YY(1-36), obestatin, cocaine- and amphetamine-regulated transcript (CART), and agouti-related protein in 30 healthy, non-obese subjects. Thirty European Caucasian adult participants were included in the study (17 men and 13 women). Body composition (body fat and lean body mass) was determined using bioelectrical impedance analysis. Read More

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http://dx.doi.org/10.4103/CJP.CJP_29_19DOI Listing
November 2019
1 Read

The association of matrix metalloproteinas-2 promoter polymorphisms with lung cancer susceptibility in Taiwan.

Chin J Physiol 2019 Sep-Oct;62(5):210-216

Graduate Institute of Biomedical Sciences, China Medical University; Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.

Matrix metalloproteinases-2 (MMP2) has been reported to be overexpressed in various types of cancer. However, the contribution of various genotypes of MMP2 to lung cancer is controversial and not yet been examined in Taiwan. Therefore, in the current study, we investigated the association of MMP2 genotypes with lung cancer risk among Taiwanese. Read More

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http://dx.doi.org/10.4103/CJP.CJP_43_19DOI Listing
November 2019

Magnesium sulfate attenuates lipopolysaccharides-induced acute lung injury in mice.

Chin J Physiol 2019 Sep-Oct;62(5):203-209

Department of Pathogenic Microbiology, Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, Yinchuan; Department of Microbiology and Molecular Biology, College of Life Science, Ningxia University, Yinchuan, Ningxia, China.

Acute lung injury (ALI) is a common and severe respiratory disease with high morbidity and mortality. Although some progress has been made in the past years, the pathogenesis of ALI is still poorly understood and the therapeutic outcome has still not been significantly improved. It is well-recognized that magnesium sulfate (MgSO) possesses potent anti-inflammation capacity. Read More

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http://dx.doi.org/10.4103/CJP.CJP_48_19DOI Listing
November 2019
1.275 Impact Factor

Adrenergic receptor beta-3 rs4994 (T>C) and liver X receptor alpha rs12221497 (G>A) polymorphism in Pakistanis with metabolic syndrome.

Chin J Physiol 2019 Sep-Oct;62(5):196-202

Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan.

The present study aimed to determine the association of adrenergic receptor beta-3 (ADRB3) rs4994 T>C and liver X receptor alpha (LXR-α) rs12221497 G>A polymorphism with metabolic syndrome (Met S) and the related traits in Pakistanis. Patients of Met S were recruited from the Endocrinology and Diabetic Clinic of Sheikh Zayed Hospital Lahore, over the time span of 6 months from July to December 2016. Single-nucleotide polymorphism (SNP) of ADRB3 was determined by restriction fragment length polymorphism and of LXR-α by amplification refractory mutation system polymerase chain reaction. Read More

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http://dx.doi.org/10.4103/CJP.CJP_45_19DOI Listing
November 2019

hayata extract and its ingredient daidzin ameliorate cyclophosphamide-induced hemorrhagic cystitis and oxidative stress through the action of antioxidation, anti-fibrosis, and anti-inflammation.

Chin J Physiol 2019 Sep-Oct;62(5):188-195

Department of Life Science, College of Science, National Taiwan Normal University, Taipei, Taiwan.

We explored the therapeutic potential of intragastric administration of traditional Chinese medicine Glycine tomentella Hayata (I-Tiao-Gung [ITG]) extract and its major component Daidzin on cyclophosphamide (CYP)-induced cystitis, oxidative stress, fibrosis, inflammation, and bladder hyperactivity in rats. Female Wistar rats were divided into control, CYP (200 mg/kg), CYP+ITG (1.17 g/kg/day), and CYP+Daidzin (12. Read More

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http://dx.doi.org/10.4103/CJP.CJP_60_19DOI Listing
November 2019

Effects of cannabinoid modulation on hypothalamic nesfatin-1 and insulin resistance.

Chin J Physiol 2019 Sep-Oct;62(5):182-187

Department of Physiology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Both nesfatin-1 and cannabinoid systems involved in the regulation of sleep, metabolism, and food intake. The relationship between cannabinoid system and nesfatin-1 levels remains to be elucidated. This study investigated nesfatin-1 and insulin resistance in 72-h rapid eye movement (REM) sleep-deprived mice under the effects of cannabinoid, and cannabinoid receptors CB1R and CB2R blocking. Read More

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http://dx.doi.org/10.4103/CJP.CJP_50_19DOI Listing
November 2019
1 Read

Action of citral on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in juvenile mice.

Chin J Physiol 2019 Sep-Oct;62(5):175-181

Department of Oral Physiology, School of Dentistry and Institute of Oral Bioscience, Jeonbuk National University, Jeonju, Republic of Korea.

The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is admitted as a pivotal site of integrating and regulating orofacial nociceptive inputs. Although citral (3,7-dimethyl-2,6-octadienal) is involved in antinociception, the action mechanism of citral on the SG neurons of the Vc has not been fully clarified yet. In this study, we examined the direct membrane effects of citral and how citral mediates responses on the SG neurons of the Vc in juvenile mice using a whole-cell patch-clamp technique. Read More

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http://dx.doi.org/10.4103/CJP.CJP_32_19DOI Listing
November 2019
1.275 Impact Factor

The effect of visuospatial resolution on discharge variability among motor units and force-discharge relation.

Chin J Physiol 2019 Jul-Aug;62(4):166-174

Institute of Allied Health Sciences; Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.

Although force steadiness varies with visuospatial information, accountable motor unit (MU) behaviors are not fully understood. This study investigated the modulation of MU discharges and force-discharge relation due to variations in the spatial resolution of visual feedback, with a particular focus on discharge variability among MUs. Fourteen young adults produced isometric force at 10% of maximal voluntary contraction (MVC) through index abduction, under the conditions of force trajectory displayed with low visual gain (LVG) and high visual gain (HVG). Read More

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http://dx.doi.org/10.4103/CJP.CJP_12_19DOI Listing
October 2019

Aloperine suppresses human pulmonary vascular smooth muscle cell proliferation via inhibiting inflammatory response.

Chin J Physiol 2019 Jul-Aug;62(4):157-165

Department of Pharmacology, College of Pharmacy; Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education; Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan 750004, PR China.

Abnormal pulmonary arterial vascular smooth muscle cells (PASMCs) proliferation is critical pathological feature of pulmonary vascular remodeling that acts as driving force in the initiation and development of pulmonary arterial hypertension (PAH), ultimately leading to pulmonary hypertension. Aloperine is a main active alkaloid extracted from the traditional Chinese herbal Sophora alopecuroides and possesses outstanding antioxidation and anti-inflammatory effects. Our group found Aloperine has protective effects on monocroline-induced pulmonary hypertension in rats by inhibiting oxidative stress in previous researches. Read More

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http://dx.doi.org/10.4103/CJP.CJP_27_19DOI Listing
October 2019
2 Reads

Effect of taurine on ethanol-induced oxidative stress in mouse liver and kidney.

Chin J Physiol 2019 Jul-Aug;62(4):148-156

Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, Nitra, Slovak Republic.

The purpose of this study was to investigate the effect of alcohol exposure on liver and kidney antioxidant systems in taurine exhibition during different time periods. Mice were divided into groups: I - control; II - alcohol (2.5 g/kg b. Read More

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http://dx.doi.org/10.4103/CJP.CJP_28_19DOI Listing
October 2019

Adenine decreases hypertrophic effects through interleukin-18 receptor.

Chin J Physiol 2019 Jul-Aug;62(4):139-147

Graduate Institute of Applied Science and Engineering; Department and Institute of Life Science, Fu-Jen Catholic University, Taipei, Taiwan.

Cardiac hypertrophy is the main cause of heart failure. Levels of circulating interleukin-18 (IL-18) have been reported to increase in congestive heart disease and cardiac hypertrophy. Relationships among IL-18 levels, IL-18 receptor (IL-18R) expression, and cardiac hypertrophy remain unclear. Read More

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http://dx.doi.org/10.4103/CJP.CJP_18_19DOI Listing
October 2019

Can royal jelly protect against renal ischemia/reperfusion injury in rats?

Chin J Physiol 2019 May-Jun;62(3):131-137

Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Royal jelly (RJ) is a honeybee secretion, has numerous medicinal properties in particular antioxidant activities. Ischemia/reperfusion (I/R) is one of the main challenges in acute kidney damage. This study was designed to assess the anti-inflammatory and protective effects of RJ against I/R-induced renal disorders. Read More

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http://dx.doi.org/10.4103/CJP.CJP_36_19DOI Listing
July 2019
6 Reads
1.275 Impact Factor

Action of chlorzoxazone on Camovement and viability in human oral cancer cells.

Chin J Physiol 2019 May-Jun;62(3):123-130

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on intracellular Ca concentrations ([Ca]) in oral cancer cells is unclear. This study examined whether chlorzoxazone altered Ca signaling and cell viability in OC2 human oral cancer cells. Read More

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http://dx.doi.org/10.4103/CJP.CJP_20_19DOI Listing
July 2019
1 Read

Altered expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, and Soluble Fms-like Tyrosine Kinase-1 in peripheral blood mononuclear cells from normal and preeclamptic pregnancies.

Chin J Physiol 2019 May-Jun;62(3):117-122

Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan.

Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality. It complicates around 2%-10% pregnancies worldwide due to imbalance between proangiogenic and anti-angiogenic factors, leading to incomplete placentation, ischemia, and endothelial dysfunction. The study was aimed to analyze the mRNA expression of vascular endothelial growth factor (VEGF) and its receptors, i. Read More

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http://dx.doi.org/10.4103/CJP.CJP_15_19DOI Listing
July 2019
5 Reads

Additive and nonadditive effects of salmon calcitonin and omega-3 fatty acids on antioxidant, hematological and bone and cartilage markers in experimental diabetic-osteoarthritic rats.

Chin J Physiol 2019 May-Jun;62(3):108-116

Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

Reports on the coexistence of diabetes mellitus and osteoarthritis in human subjects dated back to the 1960s. However, there is no account in literature on the co-manifestation of these disease conditions in experimental animals. In our previous study, we reported for the first time, the effects of pharmacological agents on glucoregulatory indices, lipid profile, and inflammatory markers in experimental diabetic-knee osteoarthritic rat. Read More

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http://dx.doi.org/10.4103/CJP.CJP_8_18DOI Listing
July 2019
2 Reads

Histone deacetylases in stroke.

Chin J Physiol 2019 May-Jun;62(3):95-107

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability to interact with not one, but multiple pathophysiological cascades at different levels that induced by the insult - cocktail therapy. Read More

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http://dx.doi.org/10.4103/CJP.CJP_22_19DOI Listing
July 2019
8 Reads

Differential effects of sympatholytic agents on the power spectrum of rats during the cooling-induced hemodynamic perturbations.

Chin J Physiol 2019 Mar-Apr;62(2):86-92

Department of Medical Research and Education, Cheng Hsin General Hospital, Taipei, Taiwan.

Cold stress-elicited hemodynamic perturbations (CEHP) its underlying mechanisms still not clear. We examined the difference of two effector arms of sympathetic outflows, the sympathoadrenal system, and postganglionic sympathetic neurons, their role in CEHP genesis by using two sympatholytic agents, fusaric acid (FA, dopamine-β-hydroxylase inhibitor) and guanethidine (GUA, norepinephrine-depleting drug). Adult male Sprague-Dawley rats were divided into three groups (n = 6, each), an intraperitoneal injection of control vehicle saline or FA or GUA and then all rats were subjected to a 10-min CS trial. Read More

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http://dx.doi.org/10.4103/CJP.CJP_7_18DOI Listing
July 2019
1 Read

Prepulse inhibition and acoustic startle response in young healthy Chinese.

Chin J Physiol 2019 Mar-Apr;62(2):80-85

Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing, China.

Prepulse inhibition (PPI) and habituation of the acoustic startle response (ASR) are considered to be effective neurobiological measures of sensorimotor gating and information processing. The deficit of PPI and habituation of ASR has been proposed to be candidate endophenotypes of schizophrenia spectrum disorders. However, there has been little information on PPI and ASR measures in Chinese. Read More

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http://dx.doi.org/10.4103/CJP.CJP_3_18DOI Listing
July 2019
1 Read