838,761 results match your criteria Chinese Journal Of Oceanology And Limnology[Journal]


Synergistic enhancement effect of MoO@Ag hybrid nanostructures for boosting selective detection sensitivity.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 18;241:118611. Epub 2020 Jun 18.

Tea Research Institute Chinese Academy of Agricultural Sciences, National Engineering Research Center for Tea Processing, Key Laboratory of Tea Biology and Resources Utilization, Ministry of Agriculture, 9 South Meiling Road, Hangzhou 310008, China.

An ex situ method was used to synthesize noble metals and metal oxide composite materials, due to the selective adsorption properties of metal oxides, the adsorption of different probe molecules by this composite structure had been studied. In the ex situ approach, we use (3-aminopropyl) diethoxy methylsilane (ATES) as a coupling agent which is easy for noble metal nanoparticles deposited on metallic oxide nanomaterials. The Raman scattering (SERS) substrate of 1D MoO nanowires (MoO-NWs) @Ag nanoparticles (Ag-NPs) hybrid surface had been fabricated. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118611DOI Listing

Mechanical control of plant morphogenesis: concepts and progress.

Authors:
Fei Du Yuling Jiao

Curr Opin Plant Biol 2020 Jun 30;57:16-23. Epub 2020 Jun 30.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Understanding how the genome encodes organismal shape is fundamental to biology. Extensive molecular genetic studies have uncovered genes regulating morphogenesis, that is, the generation of shape, however, such genes do not directly determine cell and tissue shape. Recent studies have started to elucidate how mechanical cues mediate the physical shaping of cells and tissues. Read More

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http://dx.doi.org/10.1016/j.pbi.2020.05.008DOI Listing

Low risk of category misdiagnosis of rice syrup adulteration in three botanical origin honey by ATR-FTIR and general model.

Food Chem 2020 Jun 21;332:127356. Epub 2020 Jun 21.

School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

This study is about the rice syrup adulteration determination in different botanical origin honey in the food product. Due to time-consuming and large risk of misdiagnosis, it is essential to establish a general model for adulteration detection regardless of the original category of honey. In this paper, infrared (IR) spectra combined with four supervised pattern recognition methods were employed to establish the general model for rice syrup adulteration detection in acacia, linden and jujube honey samples simultaneously. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127356DOI Listing

Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy.

Curr Opin Pharmacol 2020 Jun 30;54:1-10. Epub 2020 Jun 30.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, SAR, China; Department of Thoracic Surgery, Guangzhou Institute of Respiratory Health and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China. Electronic address:

Immune checkpoint blockade therapies that target CTLA-4 and PD-1/PD-L1 have ushered in a new era of cancer treatment. Nevertheless, a significant proportion of patients demonstrated primary or acquired resistance. Harnessing gut microbiota has been an emerging novel therapeutic strategy to overcome resistance. Read More

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http://dx.doi.org/10.1016/j.coph.2020.06.004DOI Listing

Sleep duration and cardiovascular risk factors in children and adolescents: A systematic review.

Sleep Med Rev 2020 May 19;53:101338. Epub 2020 May 19.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:

An association between short sleep duration and cardiovascular risk factors and outcomes is well demonstrated in adults. However, findings on the association in children and adolescents have been inconsistent. In this review, we searched PubMed, Embase and ISI Web of Science for eligible publications until March 16, 2020. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101338DOI Listing

Attributable risks associated with hospital outpatient visits for mental disorders due to air pollution: A multi-city study in China.

Environ Int 2020 Jun 30;143:105906. Epub 2020 Jun 30.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Aim: To determine the associations between outdoor air pollution and hospital outpatient visits for mental disorders in China.

Methods: We obtained data of 111,842 hospital outpatient visits for mental disorders from the largest hospitals of 13 cities, China, between January 01, 2013 and December 31, 2015. We collected air pollutant data including particulate matter ≤2. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105906DOI Listing

Fine particulate matter constituents and cause-specific mortality in China: A nationwide modelling study.

Environ Int 2020 Jun 30;143:105927. Epub 2020 Jun 30.

Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou 511443, China; JNU-QUT Joint Laboratory for Air Quality Science and Management, Jinan University, Guangzhou 511443, China. Electronic address:

Background: Fine particulate matter (with aerodynamic diameter ≤2.5 µm, PM) causes huge disease burden worldwide. However, evidence is still inadequate and inconsistent on the relationships between PM constituents and mortality, especially in low resource settings. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105927DOI Listing

Improved phenolic acid content and bioactivities of Salvia miltiorrhiza hairy roots by genetic manipulation of RAS and CYP98A14.

Food Chem 2020 Jun 17;331:127365. Epub 2020 Jun 17.

Laboratory of Medicinal Plant Biotechnology, College of pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China; Institute of Plant Biotechnology, School of Life Sciences, Shanghai Normal University, Shanghai 200234, PR China. Electronic address:

Phenolic acids from Salvia miltiorrhiza have been widely used in nutritious, health-promoting products with an increasing demand. In the current study, two biosynthetic genes RAS (rosmarinic acid synthase) and CYP98A14 (a cytochrome P450-dependent monooxygenase) were successfully introduced into S. miltiorrhiza hairy roots. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127365DOI Listing

Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.

Eur J Med Chem 2020 Jun 25;202:112310. Epub 2020 Jun 25.

Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China. Electronic address:

Enterovirus A71 (EV-A71) is a human pathogen causing hand, foot and mouth disease (HFMD) which seriously threatened the safety and lives of infants and young children. However, there are no licensed direct antiviral agents to cure the HFMD. In this study, a series of quinoline formamide analogues as effective enterovirus inhibitors were developed, subsequent systematic structure-activity relationship (SAR) studies demonstrated that these quinoline formamide analogues exhibited good potency to treat EV-A71 infection. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112310DOI Listing

Age-related changes in the association of resting-state fMRI signal variability and global functional connectivity in non-demented healthy people.

Psychiatry Res 2020 Jun 27;291:113257. Epub 2020 Jun 27.

Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA, United States; Institute of Brain Sciences, National Yang-Ming University, Taipei, Taiwan; Digital Medicine Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Research suggests that the aging relates to variability of resting-state fMRI (rs-fMRI) signal and the functional connectivity. However, the association between the spatial and temporal activity of resting-state fMRI signal was less documented. We recruited 477 healthy Han Chinese participants, who were separated into young, middle and old groups to investigate the relationship between the variability and global functional connectivity (gFC) in different age ranges using standard deviation (SD) of time series and gFC, respectively. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113257DOI Listing

Distribution characteristics and comparison of chemical stabilization ways of heavy metals from MSW incineration fly ashes.

Waste Manag 2020 Jun 30;113:488-496. Epub 2020 Jun 30.

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), College of Resources and Environment, Southwest University, Chongqing 400715, China; State Cultivation Base of Eco-agriculture for Southwest Mountainous Land, College of Resources and Environment, Southwest University, Chongqing 400715, China. Electronic address:

With the purpose of fully understanding the potential toxicity of heavy metals of various particle sizes in fly ash (FA) and finding an optimal chemical reagent stabilization scheme for fly ash with single or mixture reagents, basic physicochemical characteristics of FA was investigated using multiple chemical stabilization reagent schemes to stabilize heavy metals. The following compounds were used to develop single and mixed chemical stabilization schemes for heavy metals in waste incineration FA: sodium sulfide (NaS), sodium dihydrogen phosphate (NaHPO), ammonium dibutyl dithiophosphate (DDTP), and 2,4,6-tri-mercapto-S-triazine trisodium salt (TMT-15). The results showed that the various particle sizes of FA were mainly distributed in the range of 48-1700 μm. Read More

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http://dx.doi.org/10.1016/j.wasman.2020.06.032DOI Listing

SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice.

Genomics Proteomics Bioinformatics 2020 Jun 30. Epub 2020 Jun 30.

Department of Crop Genomics and Bioinformatics, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100094, China. Electronic address:

The information commons for rice (IC4R) database is a collection of 18 million single nucleotide polymorphisms (SNPs) identified by resequencing of 5152 rice accessions. Although IC4R offers ultra-high density rice variation map, these raw SNPs are not readily usable for the public. To satisfy different research utilizations of SNPs for population genetics, evolutionary analysis, association studies, and genomic breeding in rice, raw genotypic data of these 18 million SNPs were processed by unified bioinformatics pipelines. Read More

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http://dx.doi.org/10.1016/j.gpb.2020.03.002DOI Listing

Associations of Clinical Characteristics and Treatment Regimens with Viral RNA Shedding Duration in Patients with COVID-19.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Department of Urology, the Sixth Affiliated Hospital of Guangzhou Medical University, Guangdong, China. Electronic address:

Objective: The novel coronavirus disease 2019 (COVID-19) has become a global pandemic, but the factors influencing viral RNA shedding remain unclear to inform optimal control strategies.

Methods: The clinical course and viral RNA shedding pattern of 267 consecutive symptomatic COVID-19 patients admitted to the hospital from January 20, 2020 to March 15, 2020 were retrospectively evaluated.

Results: The median viral RNA shedding duration was 12 days (interquartile range, 8-16 d) after the onset of illness. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.091DOI Listing

Clinical characteristics and postoperative symptoms of adolescent endometriosis among 85 cases.

J Pediatr Adolesc Gynecol 2020 Jun 30. Epub 2020 Jun 30.

Department of General Gynecological Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Study Objective: Endometriosis is the most common cause of secondary dysmenorrhea among adolescents. Data on postoperative symptoms of the disease in adolescents are limited. This study aims to describe the clinical characteristics and postoperative symptoms of adolescent endometriosis in our center. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.021DOI Listing

A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer.

Nanomedicine 2020 Jun 30:102250. Epub 2020 Jun 30.

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, 310009, China. Electronic address:

Accurate identification of tumor tissues and their margins are still challenging for conventional clinical imaging methods during liver cancer surgery. In this study, dual-band confocal laser endomicroscopy (CLE) combined with image mosaic was used to guide liver cancer surgery. In the experiments with mice bearing orthotropic liver tumor, CLE can accurately detect the tumors and identify their margins with two excitation wavelengths of 488nm and 660nm by clinically available dyes fluorescein sodium (FS) or indocyanine green (ICG). Read More

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http://dx.doi.org/10.1016/j.nano.2020.102250DOI Listing

Tracing the sources and microbial degradation of PCBs in field sediments by a multiple-line-of-evidence approach including compound-specific stable isotope analysis.

Water Res 2020 May 27;182:115977. Epub 2020 May 27.

State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

Comprehensive monitoring is crucial for tracing micropollutants in the natural environment. To better evaluate the sources and natural attenuation of polychlorinated biphenyls (PCBs), three composite sediment cores were sampled from a closed pond near e-waste recycling plants, and a multiple-line-of-evidence approach (MLEA) including quantification, enantiomer analysis, microbial community profiling, and compound-specific isotope analysis (CSIA) was used to investigate the fate of PCBs in sediment cores. The difference in the maximum PCB concentrations and associated depths between sites 1/2 and 3 and the corresponding significant (p < 0. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115977DOI Listing

miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1.

Mol Cell Probes 2020 Jun 30:101625. Epub 2020 Jun 30.

Department of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin, 300121, PR China. Electronic address:

MicroRNA (miRNA) exerts an important part in colon cancer cell proliferation and apoptosis. Meanwhile, the dysregulation of some miRNAs is detected in colon cancer cells. However, it remains unclear about the underlying mechanism of their effects on tumor pathogenesis. Read More

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http://dx.doi.org/10.1016/j.mcp.2020.101625DOI Listing

Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study.

Int J Biol Macromol 2020 Jun 30. Epub 2020 Jun 30.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China. Electronic address:

Protein tyrosine phosphatase 1B (PTP1B) is a highly validated target for the treatment of type 2 diabetes and obesity. Previous studies have shown that bromophenols from marine red alga Rhodomela confervoides can inhibit PTP1B activity. However, traditional in vitro enzymatic assays may result in false positive activity. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.263DOI Listing

Immune responses and protective effects against Japanese encephalitis induced by a DNA vaccine encoding the prM/E proteins of the attenuated SA14-14-2 strain.

Infect Genet Evol 2020 Jun 30:104443. Epub 2020 Jun 30.

Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China. Electronic address:

Japanese encephalitis virus (JEV) is the causal pathogen of Japanese encephalitis (JE), which has become a severe public health problem and is one of the most rapidly spreading mosquito-borne diseases worldwide. Currently, there is no specific treatment for JEV. A vaccine would be an effective measure for reducing morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104443DOI Listing

A Commentary on "Efficacy of single layered intestinal anastomosis over double layered intestinal anastomosis-an open labeled, randomized controlled trial".

Int J Surg 2020 Jun 30. Epub 2020 Jun 30.

Department of General Surgery, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, Zhejiang Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2020.06.036DOI Listing

Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis.

Mol Plant 2020 Jun 30. Epub 2020 Jun 30.

National Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China. Electronic address:

Seed germination and seedling establishment are important for the reproductive success of plants, but seeds and seedlings typically encounter constantly changing environmental conditions. By inhibiting seed germination and postgerminative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors, the phytohormone abscisic acid (ABA) prevents premature germination and seedling growth under unfavorable conditions. However, little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted. Read More

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http://dx.doi.org/10.1016/j.molp.2020.06.011DOI Listing

Tongmai Yangxin pill reduces myocardial no-reflow by regulating apoptosis and activating PI3K/Akt/eNOS pathway.

J Ethnopharmacol 2020 Jun 30:113069. Epub 2020 Jun 30.

Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. Electronic address:

Ethnopharmacological Relevance: Tongmai Yangxin pill (TMYX) is derived from the Zhigancao decoction recorded in Shang han lun by Zhang Zhongjing during the Han dynasty and was further improved by Professor Ruan Shiyi, a cardiovascular expert at Tianjin University of Traditional Chinese Medicine. TMYX is used for the clinical treatment of chest pain, heartache, and qi-yin-deficiency coronary heart disease and can improve vascular endothelial function in patients with angina pectoris or coronary heart disease by up-regulating nitric oxide activity and then regulating vascular tension. Whether TMYX can further improve myocardial no-reflow by up-regulating NO activity and then dilating blood vessels remains unclear. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113069DOI Listing

Agrochemicals and obesity.

Mol Cell Endocrinol 2020 Jun 30:110926. Epub 2020 Jun 30.

Department of Developmental and Cell Biology, University of California, Irvine, CA, 92697-2300, USA; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA. Electronic address:

Obesity has become a very large concern worldwide, reaching pandemic proportions over the past several decades. Lifestyle factors, such as excess caloric intake and decreased physical activity, together with genetic predispositions, are well-known factors related to obesity. There is accumulating evidence suggesting that exposure to some environmental chemicals during critical windows of development may contribute to the rapid increase in the incidence of obesity. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110926DOI Listing

Association of Hormone-sensitive lipase (HSL) gene polymorphisms with the intramuscular fat content in two Chinese beef cattle breeds.

Genomics 2020 Jun 30. Epub 2020 Jun 30.

Poyang Lake Eco-economy Research Center, Jiujiang University, Jiujiang, Jiangxi Province 332005, People's Republic of China. Electronic address:

Hormone-sensitive lipase (HSL) was considered as an essential enzyme in glucolipid metabolism. It has been proposed to be a lead candidate gene for genetic markers of lipid deposition in livestock. The aim of this study was to identify sequence variants (SVs) of the bovine HSL gene and evaluate the relations to intramuscular fat in two indigenous Chinese beef cattle breeds. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.06.037DOI Listing

Comparative mitochondrial genome analysis of Neodontobutis hainanensis and Perccottus glenii reveals conserved genome organization and phylogeny.

Genomics 2020 Jun 30. Epub 2020 Jun 30.

The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; Institute of Deep Sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China. Electronic address:

To investigate the molecular evolution of mitochondrial genomes among the family Odontobutidae, the complete mitochondrial genomes of Neodontobutis hainanensis and Perccottus glenii were sequenced and compared with seven odontobutids species. The genome organization, base composition, codon usage, and gene arrangement of N. hainanensis exhibited high similarity to P. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.06.039DOI Listing

Plastome phylogenomics, systematics, and divergence time estimation of the Beilschmiedia group (Lauraceae).

Mol Phylogenet Evol 2020 Jun 30:106901. Epub 2020 Jun 30.

State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China.

Intergeneric relationships of the Beilschmiedia group (Lauraceae) remain unresolved, hindering our understanding of their classification and evolutionary diversification. To remedy this, we sequenced and assembled complete plastid genomes (plastomes) from 25 species representing five genera spanning most major clades of Beilschmiedia and close relatives. Our inferred phylogeny is robust and includes two major clades. Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106901DOI Listing

What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.

Metab Eng 2020 Jun 30. Epub 2020 Jun 30.

Acib - Austrian Centre of Industrial Biotechnology, 1190, Vienna, Austria, EU; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, 1190, Vienna, Austria, EU; Department of Analytical Chemistry, University of Vienna, 1010, Vienna, Austria, EU. Electronic address:

Background: Cell line-specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) cells. However, a key ingredient, namely an experimentally validated biomass function that summarizes the cellular composition, was so far missing. Read More

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http://dx.doi.org/10.1016/j.ymben.2020.06.002DOI Listing

Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging.

Fitoterapia 2020 Jun 30:104679. Epub 2020 Jun 30.

Natural Product Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address:

Segmentation-quantification is the most commonly used method for studying the tissue distribution of bioactive constituents in plant, but this method would bring uncontrollable pollution, compound migration and denaturation. Mass spectrometry imaging (MSI), as a new method developed in the past 20 years, has high sensitivity, high spatial resolution, high degree of visualization, and low risk of contamination and degeneration when studying tissue distribution of compounds. For the first time we applied matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to tissue distribution of characteristic constituents of the medicinal plant Salvia miltiorrhiza. Read More

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http://dx.doi.org/10.1016/j.fitote.2020.104679DOI Listing

Comparing the impact of various interventions to control the spread of COVID-19 in 12 countries.

J Hosp Infect 2020 Jun 30. Epub 2020 Jun 30.

Respiratory Sciences, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jhin.2020.06.029DOI Listing

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways.

Cancer Cell 2020 Jun 11. Epub 2020 Jun 11.

CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China; Department of Urology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China. Electronic address:

The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are molecularly intertwined. Here, we report that SETD2 delays prostate cancer (PCa) metastasis via its substrate EZH2. Read More

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http://dx.doi.org/10.1016/j.ccell.2020.05.022DOI Listing

Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.

Am J Hum Genet 2020 Jun 24. Epub 2020 Jun 24.

Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan; Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan; Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. Electronic address:

Sperm malformation is a direct factor for male infertility. Multiple morphological abnormalities of the flagella (MMAF), a severe form of asthenoteratozoospermia, are characterized by immotile spermatozoa with malformed and/or absent flagella in the ejaculate. Previous studies indicated genetic heterogeneity in MMAF. Read More

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http://dx.doi.org/10.1016/j.ajhg.2020.06.004DOI Listing

Monosubstituted tricationic Zn(II) phthalocyanine enhances antimicrobial photodynamic inactivation (aPDI) of methicillin-resistant (MRSA) and cytotoxicity evaluation for topical applications: and study.

Emerg Microbes Infect 2020 Jul 3:1-29. Epub 2020 Jul 3.

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong.

Antimicrobial photodynamic therapy (aPDT) has recently been proposed as an innovative approach to combat multi-drug resistant bacteria. It is known that cationic Zn(II) phthalocyanines (ZnPc) are effective in mediating aPDT against methicillin-resistant (MRSA). Here we have synthesized a ZnPc-based photosensitizer named ZnPcE previously reported by our research group to evaluate its aPDT efficacy against clinically relevant MRSAs including 4 ATCC type strains (ATCC 43300, ATCC BAA-42, ATCC BAA-43, ATCC BAA-44), two strains carrying specific antibiotic resistance mechanisms [AAC(6)'APH(2)" and RN4220/pUL5054] and 5 each from hospital- and community-associated MRSAs of important clonal types ST239, ST30 and ST59 which were previously documented to be prevalent in Hong Kong and its neighbouring countries. Read More

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http://dx.doi.org/10.1080/22221751.2020.1790305DOI Listing

The blood cells in NSCLC and the changes after RFA.

Int J Hyperthermia 2020 ;37(1):753-762

Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.

Lung cancer has attracted a lot of attention because of its high morbidity and mortality. The emergence of RFA provides a new treatment for unresectable NSCLC patients. In addition to killing lung tumors, RFA also provides new immuno-activated antigens, for the treatment of lung cancer. Read More

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http://dx.doi.org/10.1080/02656736.2020.1782486DOI Listing
January 2020

Vital volume increase versus clinical evaluation as the indication of additional radiofrequency ablation for benign thyroid nodule: a single center retrospective study.

Int J Hyperthermia 2020 ;37(1):777-785

Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China.

To compare results in patients treated with additional radiofrequency ablation (RFA) after clinical evaluation or vital volume (Va) increase. Forty patients with 42 benign thyroid nodules who underwent additional RFA were evaluated in this retrospective study. According to the different indication for additional RFA, 18 patients were divided into Vv increase group (V group) and 22 into clinical evaluation group (C group). Read More

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http://dx.doi.org/10.1080/02656736.2020.1778197DOI Listing
January 2020

"A Good Guy" Again: Biosociality in a Cancer Self-help Organization.

Med Anthropol 2020 Jul 3:1-14. Epub 2020 Jul 3.

Department of the History of Science, Tsinghua University , Beijing, China.

The notion of biosociality has been employed in the understanding of forging new forms of social groupings and other forms of social solidarity, with its feasibility and basis challenged in non-Western contexts. According to our study of a Chinese cancer self-help organization, an emergent biosociality occurs through an increasingly common diagnostic biomedical category, cancer. But what truly binds these people tighter is the pre-modern local knowledge of , as well as state ideology about living a useful life. Read More

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http://dx.doi.org/10.1080/01459740.2020.1775219DOI Listing

Genetic structure and insecticide resistance characteristics of fall armyworm populations invading China.

Mol Ecol Resour 2020 Jul 3. Epub 2020 Jul 3.

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.

The rapid wide-scale spread of fall armyworm (Spodoptera frugiperda) has caused serious crop losses globally. However, differences in the genetic background of subpopulations and the mechanisms of rapid adaptation behind the invasion are still not well understood. Here we report the assembly of a 390. Read More

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http://dx.doi.org/10.1111/1755-0998.13219DOI Listing

Diversity of endophytic fungi from the leaves of Vaccinium dunalianum.

Lett Appl Microbiol 2020 Jul 3. Epub 2020 Jul 3.

Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming, 650224, People's Republic of China.

This study was focus on investigating the community composition of endophytic fungi in the leaves of Vaccinium dunalianum Wight. Based on a combination of morphological features and molecular evidence, 239 endophytic fungal isolates belonging to 33 genera including 62 species were obtained and identified. By comparing the relative abundance (RA) values, the most frequent species belonged to Phyllosticta and Guignardia with RA of 26. Read More

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http://dx.doi.org/10.1111/lam.13345DOI Listing

CDK8 is associated with RAP2.6 and SnRK2.6 and positively modulates abscisic acid signaling and drought response in Arabidopsis.

New Phytol 2020 Jul 3. Epub 2020 Jul 3.

Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, 47907, USA.

CDK8 is a key subunit of Mediator complex, a large multi-protein complex that is a fundamental part of the conserved eukaryotic transcriptional machinery. However, the biological functions of CDK8 in plant abiotic stress responses remain largely unexplored. Here, we demonstrated CDK8 as a critical regulator in the ABA signaling and drought response pathways in Arabidopsis. Read More

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http://dx.doi.org/10.1111/nph.16787DOI Listing

Transcriptional profiling of Pseudomonas aeruginosa PAO1 in response to anti-biofilm and anti-infection agent exopolysaccharide EPS273.

J Appl Microbiol 2020 Jul 3. Epub 2020 Jul 3.

College of Life Sciences, Qingdao University, Qingdao, Shandong, China.

Aims: Relative few anti-biofilm polysaccharides against Pseudomonas aeruginosa were done to investigate the underlying molecular mechanism. Exopolysaccharide EPS273 can clearly reduce biofilm formation and infection of P. aeruginosa. Read More

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http://dx.doi.org/10.1111/jam.14764DOI Listing

Ligand Regulated Regiodivergent Hydrosilylation of Isoprene under Iron Catalysis.

Angew Chem Int Ed Engl 2020 Jul 3. Epub 2020 Jul 3.

Chinese Academy of Sciences, Dalian Institute of Chemical Physics, 457 Zhongshan Road, 116023, Dalian, CHINA.

A regiodivergent and stereoselective hydrosilylation of basic industrial feedstock isoprene with unactivated silanes has been developed using earth-abundant iron catalyst. The manipulation of regioselectivity relies on fine modification of the coordination geometry of iron center. While a bidentate pyridine imine ligand promotes the formation of allylic silanes via a 4,1-addition, the selectivity toward 3,4-adduct homoallylic silanes was achieved by switching to tridentate nitrogen ligand. Read More

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http://dx.doi.org/10.1002/anie.202007930DOI Listing

[A pedigree of L-2-hydroxyglutaric aciduria including 3 patients caused by homozygous L2HGDH variant].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):799

Department of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.024DOI Listing

[Progress in research and prenatal diagnosis for ring chromosomes].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):792-795

Department of Genetics, Shaoxing Women and Children's Hospital, Shaoxing, Zhejiang 312000, China.

Genetic counseling for ring chromosomes, particularly hereditary ring chromosomes, is still difficult. In recent years, molecular biology has provided more clues for the genetic mechanism of ring chromosomes. In this paper, the epidemiology, pathogenesis, clinical phenotype and prenatal diagnosis of ring chromosomes are reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.022DOI Listing

[Loss of zona pellucida in oocytes due to compound heterozygous variants of ZP1 gene].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):789-791

Reproductive Center of Obstetrics and Gynecology, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China.

Objective: To explore the genetic basis of a patient with primary infertility due to loss of zona pellucida.

Methods: The proband and his parents were subjected to whole exome sequencing. Candidate variants were validated by Sanger sequencing and bioinformatics analysis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.021DOI Listing

[Phenotypic and genetic analysis of a boy with a 10p15.3 deletion and partial trisomy 18p syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):785-788

Children's Hospital Affiliated of Zhengzhou University, Henan Provincial Children's Hospital, Zhengzhou Children's Hospital, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Zhengzhou, Henan 450003, China.

Objective: To delineate the nature and origin of chromosomal aberration in a girl with mental retardation.

Methods: Genomic DNA was analyzed by using single nucleotide polymorphism-based array (SNP array). The proband and her parents were subjected to routine G-banded chromosomal karyotyping analysis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.020DOI Listing

[Application of high-throughput sequencing technology for the detection of fetal copy number variations].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):779-784

Center of Genetic Testing, Qingdao Women & Children's Hospital, Qingdao, Shandong 266034, China.

Objective: To assess the value of non-invasive prenatal testing (NIPT) for the detection of fetal copy number variations (CNVs) in addition to trisomies 21, 18, and 13.

Methods: A total of 37 306 pregnant women underwent the NIPT test. For those with fetal CNVs indicated by NIPT and accepted invasive prenatal diagnosis, amniotic fluid samples were obtained for chromosomal karyotyping analysis and chromosome microarray analysis (CMA). Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.019DOI Listing

[Analysis of rs4420638A/G and -317H1/H2 polymorphisms of APOC1 gene among Chinese patients with pre-eclampsia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):774-778

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.

Objective: To assess the association of apolipoprotein (apo) C1 (APOC1) gene rs4420638A/G and -317H1/H2 polymorphisms with the risk of pre-eclampsia (PE) and the influence of their genotypes on the clinical and metabolic indexes among Chinese women.

Methods: In total 289 PE patients and 824 women with uncomplicated pregnancies were included. The rs4420638A/G genotype was determined by a Taqman real-time PCR allelic discrimination assay. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.018DOI Listing

[Prenatal diagnosis of a case of Pallister-Killian syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):771-773

Department of Medical Genetics and Prenatal Diagnosis, Women and Children's Health Care Hospital of Sichuan Province, Chengdu, Sichuan 610000, China.

Objective: To carry out G-banded chromosomal karyotyping and chromosomal microarray analysis (CMA) for a fetus featuring multiple malformations.

Methods: The fetus was found to have increased nuchal thickness, generalized edema, asymmetric lower limbs, tetralogy of Fallot, nasal bone anomaly and cleft palate. Following amniocentesis, G-band karyotyping and CMA were carried out. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.017DOI Listing

[Diagnosis of a fetus with atelosteogenesis type 2 through combined prenatal ultrasonography and whole exome sequencing].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):767-770

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Key Laboratory of Maternal-Fetal Medicine of Liaoning Province, Shenyang, Liaoning 110004, China.

Objective: To explore the genetic basis for fetus with short limbs detected by prenatal ultrasonography.

Methods: Results of clinical imaging of the fetus was collected. Amniotic fluid sample was collected through amniocentesis for the extraction of fetal DNA. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.016DOI Listing

[Analysis of clinical features and genetic variants in an infant with Bloom syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):764-766

Department of Child Healthcare, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

Objective: To analyze the clinical features and genetic variants in a 13-month-old child with Bloom syndrome.

Methods: Clinical data of the child was collected. Genetic variants were detected by high-throughput sequencing and Sanger sequencing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.015DOI Listing

[Rapid screening of a hotspot variant c.609G>A in MMACHC gene by using PCR-high-resolution melting curve analysis].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):759-763

Tianjin Pediatric Research Institute, Tianjin Children's Hospital, Tianjin 300134, China.

Objective: To carry out genetic testing for two families affected with cobalamin C (cblC) and establish a rapid method for the detection of a hotspot pathogenic variant c.609G>A of the MMACHC gene by using a PCR-high-resolution melting curve (PCR-HRM) method.

Methods: Genomic DNA was extracted from peripheral blood samples of the probands and their parents. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.014DOI Listing
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