855 results match your criteria Chinese Journal Of Natural Medicines[Journal]


Bufalin-induced cardiotoxicity: new findings into mechanisms.

Chin J Nat Med 2020 Jul;18(7):550-560

China State Institutes of Pharmaceutical Industry National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai 201203, China; Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China. Electronic address:

Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine preparations. The cardiotoxicity clearly limits its application to patients living in countries. Hence, an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse reactions. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30065-0DOI Listing

Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy.

Chin J Nat Med 2020 Jul;18(7):536-549

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

The present study was designed to investigate the targets and synergistic mechanism of Shenfu Decoction (SFD) in the treatment of heart failure. A heart failure animal models was established to evaluate the pharmacological effects of SFD for anti-heart failure, then constructed ingredient-target interaction network by developing ingredient and target databases, the Discovery sdudio software was used for molecular docking. In addition, we validated the predicted protein targets of active ingredients in SFD by using surface plasmon resonance (SPR) technology. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30064-9DOI Listing

Advances on hormone-like activity of Panax ginseng and ginsenosides.

Chin J Nat Med 2020 Jul;18(7):526-535

The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Traditional Chinese medicine (TCM) has been paid much attentions due to the prevention and treatment of steroid hormone disorders. Ginseng, the root of Panax ginseng C. A. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30063-7DOI Listing

Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells.

Chin J Nat Med 2020 Jul;18(7):517-525

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China. Electronic address:

Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell membrane. Mechanistically, NLE increased the phosphorylation and expression of c-Jun, and promoted the localization of c-Jun in the nucleus, while silencing of c-Jun by small interfering RNA (siRNA) reduced NLE-induced PD-L1. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30062-5DOI Listing

The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis.

Chin J Nat Med 2020 Jul;18(7):508-516

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530200, China.

Lung cancer is the leading cause of cancer death and the most common malignant tumor, the long-term survival of which has stagnated in the past several decades. Pileostegia tomentella Hand. Mazz is a traditional Chinese medicine called "Zhongliuteng" (ZLT) in the pharmacopeia, which has been proved to possess a potent anti-tumor effect on various cancers. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30061-3DOI Listing

Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota.

Chin J Nat Med 2020 Jul;18(7):500-507

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address:

Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly relieved AOM/DSS-induced colon tumorigenesis and development by reducing the disease activity index (DAI) scores and colon tumor load. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30060-1DOI Listing

GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy.

Chin J Nat Med 2020 Jul;18(7):491-499

Department of Pharmacy, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China. Electronic address:

Adriamycin resistance in HCC seriously hinders the treatment of patients, it is necessary to investigate the mechanisms. Autophagy is involved in adriamycin resistance and JNK2 is related to autophagy. However, whether JNK2 inducing drug resistance though autophagy is unknown. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30059-5DOI Listing

In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism.

Chin J Nat Med 2020 Jul;18(7):483-490

Institute of Agricultural Biotechnology, Jilin Academy of Agricultural Sciences, Changchun 130033, China. Electronic address:

Cucurbitacin E (CuE) is previously reported to exhibit antitumor effect by several means. In this study, CuE acted as a tyrosine kinase inhibitor interfering with the epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signaling pathway and subsequently induced apoptosis and cell cycle arrest in non-small-cell lung cancer (NSCLC) cell line A549. The apoptosis regulators, cleaved Caspases-3 and Caspases-9, were observed to be increased with the treatment of CuE. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30058-3DOI Listing

Identification of anti-cancer compounds from natural products.

Chin J Nat Med 2020 Jul;18(7):481-482

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China. Electronic address:

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http://dx.doi.org/10.1016/S1875-5364(20)30057-1DOI Listing

Sangguayin preparation prevents palmitate-induced apoptosis by suppressing endoplasmic reticulum stress and autophagy in db/db mice and MIN6 pancreatic β-cells.

Chin J Nat Med 2020 Jun;18(6):472-480

Department of pharmacy, Xiangtan Central Hospital, Xiangtan 411100, China.

Sangguayin preparation (SGY-P) is refined from the traditional Chinese medicinal compound Sangguayin, which "clears heat and promotes fluid" and "tonifies kidney and spleen" for "Xiaoke", commonly known as 'Diabetes mellitus' in clinics. Previous studies have shown that SGY-P could reduce insulin resistance and repair damaged pancreas in db/db mice, but the underlying mechanisms were unclear. Here, we investigated whether treatment with SGY-P could protect pancreatic β-cells from apoptosis and uncovered the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30054-6DOI Listing

Potential quality evaluation approach for the absolute growth years' wild and transplanted Astragali Radix based on anti-heart failure efficacy.

Chin J Nat Med 2020 Jun;18(6):460-471

Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China. Electronic address:

The quality of Astragali Radix (AR) was closely related to the growth period. However, the current commodity grades of AR were only divided by diameter but not directly related to the growth period, which leads to the contradiction between the grade standard and the quality evaluation index. Therefore, solving this problem will be the key for the quality evaluation of AR. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30053-4DOI Listing

Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation.

Chin J Nat Med 2020 Jun;18(6):446-459

Key laboratory of Microbial technology and Bioinformatics of Zhejiang Province, Zhejiang Institute of Microbiology, Hangzhou 310012, China; NMPA Key laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Zhejiang Institute of Microbiology, Hangzhou 310012, China. Electronic address:

Dendrobium officinale Kimura et Migo (D. officinale) is a famous traditional Chinese medicine (TCM). A mixture of D. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30052-2DOI Listing

Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.

Chin J Nat Med 2020 Jun;18(6):436-445

Department of Cardiology, Gansu Provincial Hospital, Lanzhou 730000, China. Electronic address:

This study investigated the effects of X-ray irradiation on primary rat cardiac fibroblasts (CFs) and its potential mechanism, as well as whether sodium tanshinone IIA sulfonate (STS) has protective effect on CFs and its possible mechanism. Our data demonstrated that X-rays inhibited cell growth and increased oxidative stress in CFs, and STS mitigated X-ray-induced injury. Enzyme-linked immuno-sorbent assay showed that X-rays increased the levels of secreted angiotensin II (Ang II) and brain natriuretic peptide (BNP). Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30051-0DOI Listing

The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin.

Chin J Nat Med 2020 Jun;18(6):425-435

State Key laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of orthodontics, West China School of Stomatology Sichuan University, Chengdu 610041, China. Electronic address:

Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30050-9DOI Listing

Advances in biosynthesis of triterpenoid saponins in medicinal plants.

Chin J Nat Med 2020 Jun;18(6):417-424

Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, China. Electronic address:

In recent years, biosynthesis of triterpenoid saponins in medicinal plants has been widely studied because of their active ingredients with diverse pharmacological activities. Various oxidosqualene cyclases, cytochrome P450 monooxygenases, uridine diphosphate glucuronosyltransferases, and transcription factors related to triterpenoid saponins biosynthesis have been explored and identified. In the biosynthesis of triterpenoid saponins, the progress of gene mining by omics-based sequencing, gene screening, gene function verification, catalyzing mechanism of key enzymes and gene regulation are summarized and discussed. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30049-2DOI Listing

Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology.

Chin J Nat Med 2020 Jun;18(6):401-416

School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits (Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30048-0DOI Listing

Overexpression of ribonucleotide reductase small subunit, RNRM, increases cordycepin biosynthesis in transformed Cordyceps militaris.

Chin J Nat Med 2020 May;18(5):393-400

Key Laboratory of Standardization of Chinese Medicine, Ministry of Education; Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine, Resources Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Cordycepin was the first adenosine analogue used as an anticancer and antiviral agent, which is extracted from Cordyceps militaris and hasn't been biosynthesized until now. This study was first conducted to verify the role of ribonucleotide reductases (RNRs, the two RNR subunits, RNRL and RNRM) in the biosynthesis of cordycepin by over expressing RNRs genes in transformed C. militaris. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30046-7DOI Listing

Alkaloid constituents from the fruits of Flueggea virosa.

Chin J Nat Med 2020 May;18(5):385-392

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address:

Three new indole alkaloids, flueindolines A-C (1-3), along with nine known alkaloids (4-12), were isolated from the fruits of Flueggea virosa (Roxb. ex Willd.) Voigt. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30045-5DOI Listing

New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens.

Chin J Nat Med 2020 May;18(5):379-384

State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S-U (1-3), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30044-3DOI Listing

Pancreatic lipase inhibitory constituents from Fructus Psoraleae.

Chin J Nat Med 2020 May;18(5):369-378

College of Basic Medical Sciences, Dalian Medical University, Dalian 116000, China. Electronic address:

Pancreatic lipase (PL), a crucial enzyme in the digestive system of mammals, has been proven as a therapeutic target to prevent and treat obesity. The purpose of this study is to evaluate and characterize the PL inhibition activities of the major constituents from Fructus Psoraleae (FP), one of the most frequently used Chinese herbs with lipid-lowering activity. To this end, a total of eleven major constituents isolated from Fructus Psoraleae have been obtained and their inhibition potentials against PL have been assayed by a fluorescence-based assay. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30043-1DOI Listing

The antibacterial activity of Berberis heteropoda Schrenk and its effect on irritable bowel syndrome in rats.

Chin J Nat Med 2020 May;18(5):356-368

College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

The dried roots of Berberis heteropoda Schrenk have traditionally been used to treat acute gastroenteritis and dysentery. The aim of this study was to confirm the antibacterial activity of an extract of Berberis heteropoda Schrenk rootin vitro and its therapeutic effects on rats with diarrhea-predominant irritable bowel syndrome (D-IBS) in vivo, as well as to identify the related signaling pathways. A water extract of Berberis heteropoda Schrenk root (BHS) inhibited the growth of S. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30042-XDOI Listing

Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling.

Chin J Nat Med 2020 May;18(5):345-355

Glycochemistry & Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Cordycepin (3'-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro and in vivo remain vague. In this study, we reported functional target molecule of cordycepin which inhibited pancreatic cancer cells growth in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30041-8DOI Listing

A review of the phytochemistry and pharmacological activities of Ephedra herb.

Chin J Nat Med 2020 May;18(5):321-344

Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China.

Ephedra herb is a traditional Chinese medicine with a long history. Conventionally, it was used as a folk phytomedicine in many ancient medical books and traditional prescriptions. Up to date, a variety of specific ingredients have been found in Ephedra herb, mainly including alkaloids, flavonoids, tannins, polysaccharides, organic acids, volatile oils, and many other active compounds. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30040-6DOI Listing

Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats.

Chin J Nat Med 2020 Apr;18(4):308-320

Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China.

Osthole is observed to have the capacity to treat pulmonary arterial hypertension (PAH) in rats, but molecular mechanism is still unknown. The present study aims to discover therapeutic targets and explore therapeutic mechanism of osthole against PAH from metabolic perspective. A rat model with PAH was successfully established with MCT, following osthole administration, then untargeted metabolomics assay was performed using UPLC-Q-TOF-MS to identify differential metabolites and associated metabolic pathways, at last mechanism investigation was done by qRT-PCR, Western blot and ELISA. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30038-8DOI Listing

Prodrugs of hydrogen sulfide and related sulfur species: recent development.

Chin J Nat Med 2020 Apr;18(4):296-307

Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, USA. Electronic address:

Hydrogen sulfide (HS) is commonly referred to as the third gasotransmitter with firmly established physiological roles. Prodrug approaches have been broadly applied to deliver HS for various applications and mechanistic studies. Since S-persulfidation and glutathionylation are known to be important in cellular signaling by sulfur species, there have been interests in developing donors of persulfide and glutathione persulfide as well. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30037-6DOI Listing

CO as a therapeutic agent: discovery and delivery forms.

Chin J Nat Med 2020 Apr;18(4):284-295

Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta GA 30303, USA. Electronic address:

Carbon monoxide (CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we discussed CO's evolution from a well-recognized toxic gas to a signaling molecule, and the effort to develop different approaches to deliver it for therapeutic application. We also summarize recently reported chemistry towards different CO delivery forms. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30036-4DOI Listing

Nitric oxide donating anti-glaucoma drugs: advances and prospects.

Chin J Nat Med 2020 Apr;18(4):275-283

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Glaucoma is a disease that causes irreversible blindness. Reducing intraocular pressure (IOP) is the main treatment at present. Nitric oxide (NO), an endogenous gas signaling molecule, can increase aqueous humor outflow facility, inhibit aqueous humor production thereby reducing IOP, as well as regulate eye blood flow and protect the optic nerve. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30035-2DOI Listing

Gaseous signaling molecules as potential therapeutic agents.

Chin J Nat Med 2020 Apr;18(4):273-274

Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/S1875-5364(20)30034-0DOI Listing

New meroterpenoid compounds from the culture of mushroom Panus lecomtei.

Chin J Nat Med 2020 Apr;18(4):268-272

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Two new meroterpenoid compounds (1 and 2) together with five known meroterpenoid derivatives (3-7) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1-7 was postulated. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30033-9DOI Listing

Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae.

Chin J Nat Med 2020 Apr;18(4):261-267

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Two new caryophyllene-type sesquiterpenoids, pestathenols A (1) and B (2) and one new α-furanone, pestatheranone A (6), along with five known compounds (3-5, 7 and 8) have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae. Their structures were unambiguously established by extensive spectroscopic analyses. The absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke's method. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30032-7DOI Listing

Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3.

Chin J Nat Med 2020 Apr;18(4):256-260

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. Electronic address:

Three new isocoumarin derivatives, (S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one (1), (S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one (2) and (R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl) propyl acetate (3), along with four known compounds (4-7) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30031-5DOI Listing

Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201.

Chin J Nat Med 2020 Apr;18(4):250-255

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; University of Chinese Academy of Sciences, Beijing 100049, China; South China Branch of Innovation Academy for Drug Discovery and Development, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address:

Penicildiones A-D (1-4), four new steroids derivatives together with three known compounds including 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5), stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft coral-derived fungus Penicillium sp. SCSIO41201, cultured in the 1% NaCl PDB substrate. Their structures were determined through spectroscopic methods and X-ray crystallography. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30030-3DOI Listing

A new iron(III) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059.

Chin J Nat Med 2020 Apr;18(4):243-249

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Institution of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou 511458, China. Electronic address:

Mycosphazine A (1), a new iron(III) chelator of coprogen-type siderophore, and mycosphamide A (2), a new cyclic amide benzoate, together with six known aryl amides (3-8), were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059. Alkaline hydrolysis of 1 afforded a new epimer of dimerum acid, mycosphazine B (1a), and a new bi-fusarinine-type siderophore, mycosphazine C (1b). Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30029-7DOI Listing

The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry.

Chin J Nat Med 2020 Apr;18(4):241-242

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/S1875-5364(20)30028-5DOI Listing

Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats.

Chin J Nat Med 2020 Mar;18(3):234-240

Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Electronic address:

Azithromycin and Chinese medicine forsythia are often used together to treat pediatric mycoplasma infections in China. We aimed to investigate the pharmacokinetic interaction of Forsythia suspensa extract and azithromycin after single and co-intravenous administration in rats. Male Sprague-Dawley rats received single (Forsythia suspensa extract or azithromycin) treatment or co-administration of Forsythia suspensa extract and azithromycin. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30026-1DOI Listing

Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats.

Chin J Nat Med 2020 Mar;18(3):226-233

Cardiology Department, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. Electronic address:

Shenfu injection (SFI), a Chinese medicinal product, shows potent efficacy in treating sepsis. The aim of the present study was to clarify the protective effects of SFI against lipopolysaccharide (LPS)-induced myocardial inflammation and apoptosis. Experiments were carried out in Sprague-Dawley (SD) rats treated with LPS or LPS + SFI, and in H9C2 cardiomyocytes. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30025-XDOI Listing

Construction and application of carbohydrate microarrays to detect foodborne bacteria.

Chin J Nat Med 2020 Mar;18(3):219-225

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address:

The rapid detection of pathogenic bacteria is vital for the prevention of outbreaks of infectious diseases, including infections by the common foodborne bacteria E.coli and Salmonella Carbohydrate microarrays have been developed as a powerful method to investigate carbohydrate-protein interaction with only very small amounts of glycans, which show great potential for detect the carbohydrate mediated interaction with pathogens. Here, different mannose-coated microarrays were constructed and tested with E. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30024-8DOI Listing

Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Schisandra sphenanthera extract) against LCA-induced cholestasis.

Chin J Nat Med 2020 Mar;18(3):211-218

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510000, China. Electronic address:

Cholestasis is caused by the obstacle of bile formation or secretion and can develop into severe liver diseases. We previously reported the ethanol extract of Schisandra sphenanthera (Wuzhi tablet, WZ) can significantly protect against lithocholic acid (LCA)-induced intrahepatic cholestasis in mice, partially due to the activation of PXR pathway and promotion of liver regeneration. However, the effect of WZ on the bile acids profile and gut microbiome in cholestastic mice remain unknown. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30023-6DOI Listing

Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP).

Chin J Nat Med 2020 Mar;18(3):206-210

School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China. Electronic address:

The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30022-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270732PMC

Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity.

Chin J Nat Med 2020 Mar;18(3):196-205

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

With the internationally growing popularity of traditional Chinese medicine (TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30021-2DOI Listing

Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice.

Chin J Nat Med 2020 Mar;18(3):186-195

Department of Microbiology, Wu Lien-Teh Institute, Harbin Medical University, Harbin 150081, China. Electronic address:

Alcoholic liver disease (ALD) has become one of the leading causes of death in the world. Berbamine (BM), a natural product mainly derived from Berberis vulgaris L, possesses multiple bioactivities as a traditional medicine. However, the protective effect of BM on ALD remains unknown. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30020-0DOI Listing

MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer.

Chin J Nat Med 2020 Mar;18(3):178-185

The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210009, China. Electronic address:

Enhanced glucose metabolism is one of the hallmarks of pancreatic cancer. MUC1, a transmembrane protein, is a global regulator of glucose metabolism and essential for progression of pancreatic cancer. To clarify the role of MUC1 in glucose metabolism, we knocked out MUC1 in Capan-1 and CFPAC-1 cells. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30019-4DOI Listing

Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice.

Chin J Nat Med 2020 Mar;18(3):169-177

Department of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, China. Electronic address:

The objective of this study was to verify the protective effect of Bifidobacterium longum (BL) and the synergistical effect of Selenium and BL on alcohol plus high fat diet (HFD) induced hepatic injury in mice. We also want to explore the mechanism of Selenium-enriched Bifidobacterium longum (SeBL). C57BL/6 mice were treated with alcohol plus HFD with or without different dosage of BL or SeBL for 4 weeks. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30018-2DOI Listing

Fatty liver diseases, mechanisms, and potential therapeutic plant medicines.

Chin J Nat Med 2020 Mar;18(3):161-168

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

The liver is an important metabolic organ and controls lipid, glucose and energy metabolism. Dysruption of hepatic lipid metabolism is often associated with fatty liver diseases, including nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver diseases (AFLD) and hyperlipidemia. Recent studies have uncovered the contribution of hormones, transcription factors, and inflammatory cytokines to the pathogenesis of dyslipidemia and fatty liver diseases. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30017-0DOI Listing

Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang ShuaiLao Pian treated mid-adult mice.

Chin J Nat Med 2020 Feb;18(2):90-102

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

With the occurrence of aging process, decreased neuron dopamine, disrupted brown adipose tissue (BAT) remodeling and decreased butyrate level all reflect a weak host healthy in certain degree. Nevertheless, the signs of mid-adult gut microbiota, and its association with host healthy are not well understood. In current study, we deemed to illustrate the associations of age, neuron dopamine, BAT remodeling, butyrate and gut microbiota with the aid of traditional herbal formula Kang Shuai Lao Pian (KSLP), which is known for its anti-aging effect. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30010-8DOI Listing
February 2020

Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells.

Chin J Nat Med 2020 Feb;18(2):81-89

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. Electronic address:

Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with the intrinsic pathway by the activation of caspase-9, -3 and -7. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30009-1DOI Listing
February 2020

Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry.

Chin J Nat Med 2020 Feb;18(2):148-160

School of Pharmacy, Binzhou Medical University, Yantai 264003, China. Electronic address:

Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical constituent analysis of organic acids, flavonoids, iridoids and new-generated compounds in sulfur-fumigated LJF (SF-LJF). Based on the accurate mass measurement (< ± 5 ppm), chromatographic behavior and diagnostic product ions (DPIs), 113 constituents were unambiguously or tentatively characterized from SF-LJF extract, including 46 chlorogenic acids, 19 flavonoids, 29 iridoid glycosides and 19 newly-generated compounds (including 17 sulfur-containing derivatives). Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30015-7DOI Listing
February 2020

Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury.

Chin J Nat Med 2020 Feb;18(2):138-147

Department of Health Laboratory Technology, School of Public Health, China Medical University, Shenyang 110122, China. Electronic address:

Glycyrrhetinic acid (GA) is the bioactive ingredient in Glycyrrhizae Radix et Rhizoma. Our previous study has reported that GA has protective effect on realgar-induced hepatotoxicity. However, the details of the hepatoprotective mechanisms of GA on realgar-induced liver injury remain to be elucidated. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30014-5DOI Listing
February 2020

Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats.

Chin J Nat Med 2020 Feb;18(2):123-137

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Fructus Psoraleae, which is commonly consumed for the treatment of osteoporosis, bone fracture, and leucoderma, induces liver injury. This study investigated the pathogenesis of the ethanol extract of Fructus Psoraleae (EEFP)-induced liver injury in rats. EEFP (1. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30013-3DOI Listing
February 2020

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells.

Chin J Nat Med 2020 Feb;18(2):114-122

Department of Bioscience and Biotechnology, Sejong University, Seoul 05006, Republic of Korea. Electronic address:

Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human cancers. Autophagy promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic cells. Here, we investigated whether varying levels of autophagic flux in glioblastoma lead to different efficacies of curcumin treatment using U87MG and A172 human glioblastoma cells. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30012-1DOI Listing
February 2020