840,508 results match your criteria Chinese Journal Of Geophysics-chinese Edition[Journal]


Antifungal mechanism of Streptomyces ma. FS-4 on fusarium wilt of banana.

J Appl Microbiol 2020 Jul 12. Epub 2020 Jul 12.

Key Laboratory of Tropical Fruit Biology, Ministry of Agriculture, South Subtropical Crop Research Institute, Chinese Academy of Tropical Agricultural Science, 524091, Zhanjiang, China.

Aim: Research on prevention and cure of banana wilt is important to ensure the healthy development of the banana industry. In this study, antifungal mechanism of Streptomyces ma. FS-4 on fusarium wilt of banana was investigated. Read More

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http://dx.doi.org/10.1111/jam.14784DOI Listing

High-resolution temporal dynamic transcriptome landscape reveals a GhCAL-mediated flowering regulatory pathway in cotton (Gossypium hirsutum L.).

Plant Biotechnol J 2020 Jul 12. Epub 2020 Jul 12.

College of Agronomy, Northwest A&F University, Yangling, 712100, Shaanxi, People's Republic of China.

The transition from vegetative to reproductive growth is very important for early maturity in cotton. However, the genetic control of this highly dynamic and complex developmental process remains unclear. A high-resolution tissue- and stage-specific transcriptome profile was generated from six developmental stages using 72 samples of two early-maturing and two late-maturing cotton varieties. Read More

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http://dx.doi.org/10.1111/pbi.13449DOI Listing

Icaritin activates Nrf2/Keap1 signaling to protect neuronal cells from oxidative stress.

Chem Biol Drug Des 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, 276004, PR China.

Our earlier study indicated that icaritin (ICT) protected mice from cerebral ischemic injury by inhibiting oxidative stress, and this study aimed to investigate its mechanism using a H O -treated SH-SY5Y cells model. Cell viability was assessed by cell counting kit 8 (CCK-8). Oxidative stress parameters were detected by flow cytometry, and signaling pathways were analyzed by immunoblotting. Read More

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http://dx.doi.org/10.1111/cbdd.13765DOI Listing

Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma.

FEBS Open Bio 2020 Jul 12. Epub 2020 Jul 12.

Center of Clinical Laboratory, First medical center of Chinese, PLA General Hospital, Beijin, 100853, China.

The identification of non-invasive biomarkers for detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long noncoding RNAs (lncRNAs) have been reported to be possible biomarkers for diagnosis and prognosis of cancer. Here, we examined the suitability of the lncRNA LINC00887 as a potential biomarker for RCC, as its expression has been shown to be elevated in RCC tissue versus normal tissue in the Gene Expression Profiling Interactive Analysis (GEPIA) database. Read More

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http://dx.doi.org/10.1002/2211-5463.12930DOI Listing

PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: A meta-analysis.

BJOG 2020 Jul 12. Epub 2020 Jul 12.

Department of Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Up to 70% of the patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down the reccurence.

Objectives: To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer. Read More

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http://dx.doi.org/10.1111/1471-0528.16411DOI Listing

Dietary supplementation with Bacillus mixture modifies the intestinal ecosystem of weaned piglets in an overall beneficial way.

J Appl Microbiol 2020 Jul 11. Epub 2020 Jul 11.

CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China.

Aims: This study was conducted to investigate the effects of dietary supplementation with a mixture of Bacillus, which serves as an alternative of antibiotics on the intestinal ecosystem of weaned piglets.

Methods And Results: We randomly assigned 120 piglets to three groups: a control group (a basal diet), a probiotics group (a basal diet supplemented with 4 × 10 cfu g Bacillus licheniformis-Bacillus. subtilis mixture; BLS mix), and an antibiotics group (a basal diet supplemented with 0. Read More

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http://dx.doi.org/10.1111/jam.14782DOI Listing

Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells.

Oral Dis 2020 Jul 12. Epub 2020 Jul 12.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China.

Objective: There were rarely investigations on the effects and molecular mechanisms of oral squamous cell carcinoma (OSCC) cells when treated with isorhamnetin. This article assesses the anticancer effect of isorhamnetin.

Methods And Materials: OSCC cells were treated with or without isorhamnetin. Read More

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http://dx.doi.org/10.1111/odi.13548DOI Listing

Enolase-phosphatase 1 acts as an oncogenic driver in glioma.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China.

Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in l-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. Read More

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http://dx.doi.org/10.1002/jcp.29926DOI Listing

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.

Hepatology 2020 Jul 12. Epub 2020 Jul 12.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.

To identify the regulatory role of protein phosphatase 2A (PP2A) in the development of liver disease, we generated a mouse model with hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit). Homozygote (HO) mice and matched wild-type (WT) littermates were investigated at 3, 6, 9, 12, 15, and 18 months-of-age, respectively. Pathological examination showed that PP2A Aα deficiency in hepatocytes resulted in progressive liver fibrosis phenotype from 9 months-of-age. Read More

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http://dx.doi.org/10.1002/hep.31457DOI Listing

Long-term results of the edge-to-edge repair for failed mitral valve repair as a bailout option.

Gen Thorac Cardiovasc Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Surgery, Fuwai Hospital, Chinese Academy of Medical Science, No. 167, North Lishi Road, Xicheng District, Beijing, 100037, China.

Objective: We evaluate the long-term clinical and echocardiographic outcomes of edge-to-edge (E2E) repair combined with mitral annuloplasty in our institute with degenerative mitral regurgitation (MR) up to 10 years.

Methods: Twenty-six consecutive patients undergoing E2E mitral repair after failure of other conventional mitral repair technique. There were 16 (61. Read More

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http://dx.doi.org/10.1007/s11748-020-01433-zDOI Listing

Comparison of efficacy and safety of urate-lowering therapies for hyperuricemic patients with gout: a meta-analysis of randomized, controlled trials.

Clin Rheumatol 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine, Division of Rheumatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.

Objectives: To assess the efficacy and safety of the commonly used urate-lowering therapies (ULTs): febuxostat, allopurinol, and lesinurad in hyperuricemic patients with gout.

Methods: We included all randomized controlled trials (RCTs) that compared ULTs with placebo or head to head. The primary efficacy endpoint was the proportion of subjects achieving the target serum urate (SU) level at month 6. Read More

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http://dx.doi.org/10.1007/s10067-020-05272-4DOI Listing

WSL9 Encodes an HNH Endonuclease Domain-Containing Protein that Is Essential for Early Chloroplast Development in Rice.

Rice (N Y) 2020 Jul 11;13(1):45. Epub 2020 Jul 11.

State Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.

Background: The plant chloroplast is essential for photosynthesis and other cellular processes, but an understanding of the biological mechanisms of plant chloroplast development are incomplete.

Results: A new temperature-sensitive white stripe leaf 9(wsl9) rice mutant is described. The mutant develops white stripes during early leaf development, but becomes green after the three-leaf stage under field conditions. Read More

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http://dx.doi.org/10.1186/s12284-020-00407-2DOI Listing

Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer.

Cancer Chemother Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.

Gemcitabine (GEM), as an anti-metabolic nucleoside analog, has been shown to have anticancer effects in various tumors, but its chemotherapy resistance is still an important factor leading to poor prognosis of cancer patient. A large number of studies in recent years have shown that autophagy plays an important role in the chemotherapy sensitivity of many tumors, including pancreatic, non-small cell lung, and bladder cancer. However, whether GEM causes autophagy in gallbladder cancer (GBC) and whether it is related to chemotherapy resistance is unknown. Read More

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http://dx.doi.org/10.1007/s00280-020-04100-5DOI Listing

Clinical outcomes of revision with retrograde intermedullary nailing for failed plating of distal femoral fractures: a retrospective study.

Int Orthop 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopaedics, Traditional Chinese Medicine Hospital, Southwest Medical University, 182# Chunhui Road, Luzhou, 646000, Sichuan, People's Republic of China.

Purpose: To assess the feasibility and effectiveness of retrograde intramedullary nail (RIN) revision surgeries for locking compression plate (LCP) failure in distal femoral fractures.

Methods: This retrospective study included 13 patients who suffered from metalwork failures after they initially underwent open reduction and LCP fixation. In patients who eventually underwent RIN revision from January 2014 to December 2016, range of motion (ROM) and Hospital for Special Surgery (HSS) scores obtained before surgery and at the final follow-up time were analysed. Read More

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http://dx.doi.org/10.1007/s00264-020-04621-xDOI Listing

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance.

Cell Mol Life Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Stomatology, NHC Key Laboratory of Carcinogenesis, Xiangya Hospital, Central South University, Changsha, 410078, China.

The successful treatment of human cancers by immunotherapy has been made possible by breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD-1/PD-L1. However, the immunosuppressive effect of the tumor microenvironment still represents an important bottleneck that limits the success of immunotherapeutic approaches. The tumor microenvironment influences the metabolic crosstalk between tumor cells and tumor-infiltrating immune cells, creating competition for the utilization of nutrients and promoting immunosuppression. Read More

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http://dx.doi.org/10.1007/s00018-020-03581-0DOI Listing

Anterior release without odontoidectomy for irreducible atlantoaxial dislocation: transoral or endoscopic transnasal?

Eur Spine J 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopaedic Surgery, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing, 100029, China.

Purpose: To compare transoral and endoscopic transnasal anterior release without odontoidectomy and posterior reduction and fixation to treat irreducible atlantoaxial dislocation (IAAD).

Methods: From June 2006 to January 2017, 35 consecutive patients with IAAD underwent transoral (Tr-Oral group) or endoscopic transnasal (Tr-Nasal group) release and posterior fixation and fusion in our department. Clinical neurological recovery (Japanese Orthopedic Association (JOA) score) and radiological reduction parameters including atlantodontoid interval (ADI), space available for the cord (SAC) and cervicomedullary angle (CMA) were analyzed and compared. Read More

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http://dx.doi.org/10.1007/s00586-020-06527-zDOI Listing

Paleolithic genetic link between Southern China and Mainland Southeast Asia revealed by ancient mitochondrial genomes.

J Hum Genet 2020 Jul 11. Epub 2020 Jul 11.

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, CAS, 100044, Beijing, China.

The genetic history of Southern East Asians is not well-known, especially prior to the Neolithic period. To address this, we successfully sequenced two complete mitochondrial genomes of 11,000-year-old human individuals from Southern China, thus generating the oldest ancient DNA sequences from this area. Integrating published mitochondrial genomes, we characterized M71d, a new subhaplogroup of haplogroup M71. Read More

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http://dx.doi.org/10.1038/s10038-020-0796-9DOI Listing
July 2020
2.462 Impact Factor

Effects of calcium dobesilate (CaD) interference on serum creatinine measurements: a national External Quality Assessment (EQA)-based educational survey of drug-laboratory test interactions.

Clin Chem Lab Med 2020 Jul 13. Epub 2020 Jul 13.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, PR China.

Objectives Drug-laboratory test interactions (DLTIs) are one of the major sources of laboratory errors. Calcium dobesilate (CaD) interference on serum creatinine testing is a widespread problem that has long been ignored in China. A national EQA-based survey was launched to investigate the current status of CaD interference on creatinine routine methods used in China and enhance the education of CaD interference in clinical laboratories. Read More

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http://dx.doi.org/10.1515/cclm-2020-0424DOI Listing

Selective bioimaging of cancer cells and detection of HSA with indomethacin-based fluorescent probes.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 6;241:118685. Epub 2020 Jul 6.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Two fluorescent probes were designed by connecting indomethacin to coumarin through different linkers. The introduction of indomethacin quenched the fluorescence of coumarin-based probes with apparent red-shifts in the absorption and emission maxima, probably due to the photoinduced electron transfer (PET) from the indomethacin to the fluorophore and the formation of folding conformation. The addition of human serum albumin (HSA) triggered about 40-fold fluorescence enhancements of ADC-IMC-2 and ADC-IMC-6 with 85 nm blue-shifts. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118685DOI Listing

An integrative metabolomics and network pharmacology method for exploring the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba on anti-depression.

J Pharm Biomed Anal 2020 Jul 2;189:113435. Epub 2020 Jul 2.

Heilongjiang University of Chinese Medicine, Harbin, 150040, China; Guangdong Pharmaceutical University, Guangdong, 510006, China. Electronic address:

Depression is a common mental illness, which is caused by 'liver qi stagnationin in traditional Chinese medicine (TCM) theory. Thus, relieving "liver qi stagnation" is considered to be effective at treating depression. The Radix Bupleuri and Radix Paeoniae Alba drug pair is the most classic compatible drug pair for mitigating a great variety of depression symptoms. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113435DOI Listing

Associations of prenatal exposure to multiple metals with testicular volume and anogenital distance in infant boys: A longitudinal cohort study.

Environ Int 2020 Jul 9;143:105900. Epub 2020 Jul 9.

Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, China; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China. Electronic address:

Background: Human are widely exposed to multiple metals, some of which have suspected reproductive toxicity, but no human studies have investigated the developmental effects of prenatal metal exposure.

Objectives: We aimed to evaluate the associations between prenatal multiple metal exposure and reproductive development in boys at 2-3 years using multi-pollutant approach.

Methods: This prospective study used data of 564 mother-child pairs recruited from the Guangxi Birth Cohort Study. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105900DOI Listing

TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway.

J Hazard Mater 2020 Jun 30;401:123341. Epub 2020 Jun 30.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Halogenated flame retardants (HFRs), including Tetrabromobisphenol A (TBBPA), Tetrabromobisphenol S (TBBPS), and Tetrachlorobisphenol A (TCBPA), are widely applied in the manufacturing industry to improve fire safety and can be detected in pregnant women's serum at nanomolar levels. Thus, it is necessary to pay attention to the three HFR potential development toxicity, which has not been conclusively addressed yet. The liver is the main organ that detoxifies our body; TBBPA exposure may lead to increased liver weight in rodents. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123341DOI Listing

Characterizing metabolites and potential metabolic pathways changes to understanding the mechanism of medicinal plant Phellodendri Amurensis cortex against doxorubicin-induced nephritis rats using UPLC-Q/TOF-MS metabolomics.

J Pharm Biomed Anal 2020 May 22;188:113336. Epub 2020 May 22.

Heilongjiang University of Traditional Chinese Medicine, Heping Road 24, Harbin, 150040, China; Guangdong Pharmaceutical University, Huandong Road 280, Guangzhou, 510006, China. Electronic address:

Phellodendri Amurensis cortex (PAC), a famous traditional Chinese herb with good anti-inflammatory efficacy, is used to treat various liver and kidney sickness in clinical practice. However, the potential mechanisms protecting against nephritis of PAC have not been comprehensively elucidated. The aim of this research was to explore the mechanism of PAC against doxorubicin- induced nephritis in rats by characterizing metabolites and potential metabolic pathways changes. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113336DOI Listing

Impact of quarantine measures on chemical compositions of PM during the COVID-19 epidemic in Shanghai, China.

Sci Total Environ 2020 Jul 6;743:140758. Epub 2020 Jul 6.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; Institute of Eco-Chongming (IEC), 20 Cuiniao Rd., Chenjia Zhen, Chongming, Shanghai 202162, China. Electronic address:

The COVID-19 epidemic broke out in Wuhan, Hubei in December 2019 and in January 2020 and was later transmitted to the entire country. Quarantine measures during Chinese New Year effectively alleviated the spread of the epidemic, but they simultaneously resulted in a decline in anthropogenic emissions from industry, transportation, and import and export of goods. Herein, we present the major chemical composition of non-refractory PM (NR-PM) and the concentrations of gaseous pollutants in an urban site in Shanghai before and during the quarantine period of the COVID-19 epidemic, which was Jan. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140758DOI Listing

Nitrogen use efficiency, crop water productivity and nitrous oxide emissions from Chinese greenhouse vegetables: A meta-analysis.

Sci Total Environ 2020 Jul 5;743:140696. Epub 2020 Jul 5.

College of Natural Resources and Environment, Northwest A&F University, Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture and Rural Affairs, 712100 Yangling, China.

Greenhouse vegetable cultivation is a substantial source of nitrous oxide (NO) emissions in China due to intensive managements with nitrogen (N) fertilizers and irrigation water. We hypothesize that reducing input rates of N fertilizers or irrigation water to optimal levels would mitigate NO emissions without significant loss of vegetable yields. The primary aims of this study are to (i) quantify the variations in vegetable yields, NO emissions, nitrogen use efficiency (NUE) and crop water productivity (CWP) under greenhouse cultivation conditions; (ii) determine the major regulating factors of vegetable yields, NO emissions, emission factors (EFs), yield-scaled NO emissions, NUEs and CWPs; and (iii) evaluate the effectiveness of fertilization and irrigation strategies for NO mitigation. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140696DOI Listing

Thermal acclimation of leaf dark respiration of Larix gmelinii: A latitudinal transplant experiment.

Sci Total Environ 2020 Jul 3;743:140634. Epub 2020 Jul 3.

Center for Ecological Research, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, China. Electronic address:

The response of tree leaf dark respiration (R) to temperature change is important in modeling and predicting forest carbon (C) cycling under climate change, but it has rarely been investigated in nature. We conducted a field experiment by transplanting the trees of Larix gmelinii - the dominant tree species in Chinese boreal forests from four latitudinal sites to a common garden near the warm border of its range. Our objective was to explore thermal acclimation of R and the underlying mechanisms by comparing the temperature-response curves of R and related leaf traits both in the common garden and at the original sites. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140634DOI Listing

Combined application of biochar with urease and nitrification inhibitors have synergistic effects on mitigating CH emissions in rice field: A three-year study.

Sci Total Environ 2020 Jul 3;743:140500. Epub 2020 Jul 3.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

Biochar and inhibitors applications have been proposed for mitigating soil greenhouse gas emissions. However, how biochar, inhibitors and the combination of biochar and inhibitors affect CH emissions remains unclear in paddy soils. The objective of this study was to explore the effects of biochar application alone, and in combination with urease (hydroquinone) and nitrification inhibitors (dicyandiamide) on CH emissions and yield-scaled CH emissions during three rice growing seasons in the Taihu Lake region (Suzhou and Jurong), China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140500DOI Listing

Rapid analysis of anthocyanin and its structural modifications in fresh tomato fruit.

Food Chem 2020 Jul 4;333:127439. Epub 2020 Jul 4.

Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture, Sino-Dutch Joint Laboratory of Horticultural Genomics, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address:

Anthocyanin is derived from a flavylium cation structure, and it promotes health in humans and functions in plants as protection against environmental stress. The rapid analysis of anthocyanin structure and content is a critical challenge for improving fruit quality. In this study, the tomato cultivar Indigo Rose, which is a popular purple cultivated tomato used for breeding, was taken as an example for anthocyanin analysis. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127439DOI Listing

Study on the bioaccessibility and bioavailability of perchlorate in different food matrices in vitro.

Food Chem 2020 Jul 4;333:127470. Epub 2020 Jul 4.

Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, Hubei, People's Republic of China. Electronic address:

Perchlorate, a persistent pollutant, interferes with iodine uptake by the thyroid. Perchlorate exposure mainly occurs through ingested food; understanding the bioaccessibility and bioavailability of perchlorate in foods facilitate more accurate human health risk assessments. An in vitro digestion/Caco-2 cell model was used for this research. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127470DOI Listing

The study on the treatment of Xuebijing injection (XBJ) in adults with severe or critical Corona Virus Disease 2019 and the inhibitory effect of XBJ against SARS-CoV-2.

Pharmacol Res 2020 Jul 9:105073. Epub 2020 Jul 9.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, PR China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau; KingMed Virology Diagnostic & Translational Center, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2020.105073DOI Listing

Analysis on the Current Quality Standards of Chinese Materia Medica Used in COVID-19 Prevention and Treatment.

Pharmacol Res 2020 Jul 9:105074. Epub 2020 Jul 9.

Institute of TCM International Standardization, Shuguang hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Purpose: Traditional Chinese medicine (TCM) has fully engaged and played an essential role in the prevention and treatment of Coronavirus Disease 2019 (COVID-19). This study compares relevant standards on high-frequent Chinese Materia Medicia (CMM) used in this pandemic aiming at reaching a global consensus and ensuring the use of Chinese medicines safely.

Methods: 141 representative Chinese formulas and Chinese Patent Medicines from the National Protocol and the most of Provincial Protocols for controlling COVID-19 in China have been collected to statistical analyze the composition and characteristics of CMM. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.105074DOI Listing

Efficient solid-state fermentation for the production of 5-aminolevulinic acid enriched feed using recombinant Saccharomyces cerevisiae.

J Biotechnol 2020 Jul 9. Epub 2020 Jul 9.

Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering of Ministry of Education, SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2020.06.001DOI Listing

Micelle driven oxidation mechansim and novel oxidation markers for different grades of polysorbate 20 and 80.

J Pharm Sci 2020 Jul 9. Epub 2020 Jul 9.

Coriolis Pharma Research, Fraunhoferstr. 18 b, 82152 Martinsried, Germany. Electronic address:

Different types and quality grades of polysorbate (PS) were subjected to oxidative stress (in absence of protein), and novel oxidation markers were discovered by our newly developed liquid chromatography-mass spectrometry (LC-MS) screening method. These markers confirmed that the more homogeneous, PS grades, such as PS80 all.oleate grade (compliant with Chinese pharmacopeia) and PS20 all-laurate grades are more prone to oxidative degradation compared to their multicompendial grade analogues. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.06.028DOI Listing

20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway.

Biochem Pharmacol 2020 Jul 9:114145. Epub 2020 Jul 9.

Research Center of Traditional Chinese Medicine, the Affiliated Hospital to Changchun University of Chinese Medicine, 1478 Gongnong Street, Changchun, Jilin Province, 130021, PR China; Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education. Electronic address:

We previously found that 20(S)-ginsenoside Rg3 (S-Rg3) promotes myoblast differentiation via an unknown mechanism. Here we measured levels of myosin heavy chain (MHC) and myogenin, markers of myoblast differentiation, using Western blot analysis and immunofluorescence staining. Notably, S-Rg3 treatment of C2C12 myoblasts led to increased muscle differentiation and protection from muscle atrophy in a dexamethasone (DEX)-treated C2C12 myotube-based muscle atrophy model. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114145DOI Listing

Impact of Aeromonas hydrophila and infectious spleen and kidney necrosis virus infections on susceptibility and host immune response in Chinese perch (Siniperca chuatsi).

Fish Shellfish Immunol 2020 Jul 10;105:117-125. Epub 2020 Jul 10.

College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. Electronic address:

Co-infections with pathogenic microorganisms are common in aquaculture, resulting in more serious economic losses than single-pathogen infection. Infection of Aeromonas hydrophila (A. hydrophila) often occurs together with infectious spleen and kidney necrosis virus (ISKNV) in Chinese perch (Siniperca chuatsi) culture ponds. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.07.012DOI Listing

Neuroanatomical Substrates and Predictors of Response to Capsulotomy in Intractable Obsessive-Compulsive Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2020 May 20. Epub 2020 May 20.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China. Electronic address:

Background: Anterior capsulotomy that surgically targets fiber tracts connecting prefrontal cortex and subcortical nuclei is a therapeutic option for a subgroup of patients with treatment-refractory obsessive-compulsive disorder. The goal of this study was to investigate neural correlates to anterior capsulotomy and find predictors of clinical improvement following this procedure.

Methods: Structural and diffusion imaging data and clinical evaluation were acquired from 31 patients with refractory obsessive-compulsive disorder who underwent anterior capsulotomy. Read More

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http://dx.doi.org/10.1016/j.bpsc.2020.05.005DOI Listing

Full-length transcriptome sequencing and modular organization analysis of oleanolic acid- and dammarane-type saponin related gene expression patterns in Panax japonicus.

Genomics 2020 Jul 9. Epub 2020 Jul 9.

School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address:

The saponins found in Panax japonicus, a traditional medicinal herb in Asia, exhibit high degrees of structural and functional similarity. In this study, metabolite analysis revealed that oleanolic acid-type and dammarane-type saponins were distributed unevenly in three tissues (rhizome_Y, rhizome_O, and secRoot) of P. japonicus. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.06.045DOI Listing

Insight into osteoarthritis through integrative analysis of metabolomics and transcriptomics.

Clin Chim Acta 2020 Jul 9. Epub 2020 Jul 9.

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China. Electronic address:

Lack of clinically specific biomarkers has impeded the diagnosis of osteoarthritis (OA) and limited understanding of pathogenesis for OA has also restrained the enhancement of therapeutic measures. In the study, plasma untargeted metabolomics of twelve OA patients and twenty healthy controls (HC) were analyzed by gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC/Q-TOF-MS). The differential metabolites (DMs) between OA and HC were evaluated by multivariate analysis and Bayes discriminant analysis was employed to discover potential diagnosis biomarkers. Read More

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http://dx.doi.org/10.1016/j.cca.2020.07.010DOI Listing

Amplitude of QRS complex within initial 40 ms in V (VQRS): Novel electrocardiographic criterion for predicting accurate localization of outflow tract ventricular arrhythmia origin.

Heart Rhythm 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: The initial depolarization vector of outflow tract (OT) ventricular arrhythmia (VA) varies in different origins, which may help to predict OT-VA origin more accurately.

Objective: To develop a more accurate electrocardiographic (ECG) criterion for differentiating between left and right OT-VA origins.

Methods: We studied 275 patients with successful ablation in the right ventricular OT (RVOT; n =207) or left ventricular OT (LVOT; n =68) in development cohort. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.07.006DOI Listing

Characterization of two kcnk3 genes in rabbitfish (Siganus canaliculatus): Molecular cloning, distribution patterns and their potential roles in fatty acids metabolism and osmoregulation.

Gen Comp Endocrinol 2020 Jul 9:113546. Epub 2020 Jul 9.

College of Marine Sciences of South China Agricultural University & Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642 China. Electronic address:

KCNK3 is a two-pore-domain (K) potassium channel involved in maintaining ion homeostasis mediating thermogenesis controlling breath and modulating electrical membrane potential. Although the functions of this channel have been widely described in mammals its roles in fishes are still rarely known. Here we identified two kcnk3 genes from the euryhaline rabbitfish (Siganus canaliculatus) and their roles related to fatty acids metabolism and osmoregulation were investigated. Read More

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http://dx.doi.org/10.1016/j.ygcen.2020.113546DOI Listing

New insights for screening etomidate analogues in the human H295R cell model.

Toxicol In Vitro 2020 Jul 9:104934. Epub 2020 Jul 9.

Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu 610041, Sichuan, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:

Etomidate is a sedative-hypnotic with excellent pharmacological effects, including rapid onset and hemodynamic stability. However, etomidate causes adrenocortical toxicity via binding to 11β-hydroxylase. Therefore, developing an approach to screen new etomidate analogues without endocrine-disrupting effects is urgently warranted. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104934DOI Listing

Executive summary of the 2020 KDIGO Diabetes Management in CKD Guideline: Evidence-based advances in monitoring and treatment.

Kidney Int 2020 Jul 9. Epub 2020 Jul 9.

Steno Diabetes Center, University of Denmark, Copenhagen, Denmark. Electronic address:

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on Diabetes Management in Chronic Kidney Disease represents the first KDIGO guideline on this subject. The guideline comes at a time when advances in diabetes technology and therapeutics offer new options to manage the large population of patients with diabetes and CKD at high risk of poor health outcomes. An enlarging base of high-quality evidence from randomized clinical trials is available to evaluate important new treatments offering organ protection, such as sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists. Read More

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http://dx.doi.org/10.1016/j.kint.2020.06.024DOI Listing

Function-based dementia severity assessment for vascular cognitive impairment.

J Formos Med Assoc 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan; Department of Nursing, College of Nursing and Health Sciences, Da-Yeh University, Dacun, Changhua, Taiwan. Electronic address:

Background/purposes: Unimpaired activities of daily living (ADL) is essential for the diagnosis of normal cognition and mild cognitive impairment. However, diagnosis according to this concept is difficult to apply to patients comorbid with motor dysfunction. We aim to use a novel ADL questionnaire for operationally diagnosing unimpaired ADL in vascular cognitive impairment with no dementia (VCIND). Read More

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http://dx.doi.org/10.1016/j.jfma.2020.07.001DOI Listing

Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation.

J Pharmacol Sci 2020 Jul 3. Epub 2020 Jul 3.

Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus. Read More

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http://dx.doi.org/10.1016/j.jphs.2020.07.002DOI Listing

The Anesthetic Management of the First Lung Transplant for a Patient with COVID-19 Respiratory Failure.

J Cardiothorac Vasc Anesth 2020 Jun 10. Epub 2020 Jun 10.

Department of Anesthesiology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1053/j.jvca.2020.06.011DOI Listing

Pollution sources of atmospheric fine particles and secondary aerosol characteristics in Beijing.

J Environ Sci (China) 2020 Sep 16;95:91-98. Epub 2020 Apr 16.

School of Municipal and Environmental Engineering, Co-Innovation Center for Green Building of Shandong Province, Shandong Jianzhu University, Jinan 250101, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China. Electronic address:

To investigate the secondary formation and pollution sources of atmospheric particles in urban Beijing, PM and its chemical components were collected and determined by URG-9000D ambient ion monitor (AIM) from March 2016 to January 2017. Among water-soluble ions (WSIs), NO, SO and NH (SNA) had the largest proportion (77.8%) with the total concentration of 23. Read More

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http://dx.doi.org/10.1016/j.jes.2020.04.002DOI Listing
September 2020

Hygroscopic properties of sodium and potassium salts as related to saline mineral dusts and sea salt aerosols.

J Environ Sci (China) 2020 Sep 9;95:65-72. Epub 2020 Apr 9.

State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; University of Chinese Academy of Sciences, Beijing 100049, China; Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

Mineral dust, soil, and sea salt aerosols are among the most abundant primary inorganic aerosols in the atmosphere, and their hygroscopicity affects the hydrological cycle and global climate. We investigated the hygroscopic behaviors of six Na- and K-containing salts commonly found in those primary organic aerosols. Their hygroscopic growths as a function of relative humidity (RH) agree well with thermodynamic model prediction. Read More

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http://dx.doi.org/10.1016/j.jes.2020.03.046DOI Listing
September 2020

Relationships between chemical elements of PM and O in Shanghai atmosphere based on the 1-year monitoring observation.

J Environ Sci (China) 2020 Sep 29;95:49-57. Epub 2020 Apr 29.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China. Electronic address:

Mass level of fine particles (PM) in main cities in China has decreased significantly in recent years due to implementation of Chinese Clean Air Action Plan since 2013, however, O pollution is getting worse than before, especially in megacities such as in Shanghai. In this work, O and PM were continuously monitored from May 27, 2018 to March 31, 2019. Our data showed that the annual average concentration of PM and O (O-8 hr, maximum 8-hour moving average of ozone days) was 39. Read More

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http://dx.doi.org/10.1016/j.jes.2020.03.043DOI Listing
September 2020

Studies on relationships between air pollutants and allergenicity of Humulus Scandens pollen collected from different areas of Shanghai.

J Environ Sci (China) 2020 Sep 30;95:43-48. Epub 2020 Apr 30.

School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.

Pollen pollution and allergy are becoming prominent issues in China. However, few studies on pollinosis have been reported. As an allergen in the atmosphere, allergenic Humulus scandens pollen was collected from four districts of Shanghai, including Wusong (WS), Jiading (JD), Xujiahui (XJH) and Songjiang (SJ). Read More

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http://dx.doi.org/10.1016/j.jes.2020.03.037DOI Listing
September 2020

Vertical profiles of biogenic volatile organic compounds as observed online at a tower in Beijing.

J Environ Sci (China) 2020 Sep 1;95:33-42. Epub 2020 May 1.

State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; Center for Excellence in Regional Atmospheric Environment Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Vertical profiles of isoprene and monoterpenes were measured by a proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) at heights of 3, 15, 32, 64, and 102 m above the ground on the Institute of Atmospheric Physics (IAP) tower in central Beijing during the winter of 2016 and the summer of 2017. Isoprene mixing ratios were larger in summer due to much stronger local emissions whereas monoterpenes were lower in summer due largely to their consumption by much higher levels of ozone. Isoprene mixing ratios were the highest at the 32 m in summer (1. Read More

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http://dx.doi.org/10.1016/j.jes.2020.03.032DOI Listing
September 2020
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