2 results match your criteria Chinese Journal Of Chemistry[Journal]

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Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CL Inhibitors.

Chin J Chem 2013 Sep 19;31(9):1199-1206. Epub 2013 Jul 19.

College of Pharmacy, Nankai University, Tianjin 300071, China.

SARS CoV 3CL is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome (SARS). A quinolinone compound was selected via virtual screening, and it was synthetized and tested for enzymatic inhibition . Compound showed potent inhibitory activity (IC=0. Read More

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http://dx.doi.org/10.1002/cjoc.201300392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159103PMC
September 2013

Discovery of anti-SARS coronavirus drug based on molecular docking and database screening.

Chin J Chem 2004 Aug 26;22(8):882-887. Epub 2010 Aug 26.

Laboratory of Computer Chemistry. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

The active site of 3CL proteinase (3CL) for coronavirus was identified by comparing the crystal structures of human and porcine coronavirus. The inhibitor of the main protein of rhinovirus (Ag7088) could bind with 3CL of human coronavirus, then it was selected as the reference for molecular docking and database screening. The ligands from two databases were used to search potential lead structures with molecular docking. Read More

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http://dx.doi.org/10.1002/cjoc.20040220825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162226PMC
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