5 results match your criteria Chinese Chemical Letters[Journal]

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CRISPR-Cas13a mediated nanosystem for attomolar detection of canine parvovirus type 2.

Chin Chem Lett 2019 Dec 31;30(12):2201-2204. Epub 2019 Oct 31.

College of Life Science, Yangtze University, Jingzhou 434025, China.

Canine parvovirus type 2 (CPV-2) infection is the most lethal disease of dogs with higher mortality in puppies worldwide. In today's world, dogs are an integral part of our communities as well as dogs breeding and rearing has become a lucrative business. Therefore, a fast, accurate, portable, and cost-effective CPV-2 detection method with the ability for on-site detection is highly desired. Read More

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http://dx.doi.org/10.1016/j.cclet.2019.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129497PMC
December 2019

Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives.

Chin Chem Lett 2019 Feb 24;30(2):392-394. Epub 2018 May 24.

Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.

A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy. Read More

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http://dx.doi.org/10.1016/j.cclet.2018.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874410PMC
February 2019

Pediatric ocular nanomedicines: Challenges and opportunities.

Chin Chem Lett 2017 Sep 26;28(9):1817-1821. Epub 2017 Jul 26.

Department of Chemical & Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States.

The eye is a highly complex, yet readily accessible organ within the human body. As such, the eye is an appealing candidate target for a vast array of drug therapies. Despite advances in ocular drug therapy research, the focus on pediatric ocular drug delivery continues to be highly underrepresented due to the limited number of degenerative ocular diseases with childhood onset. Read More

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http://dx.doi.org/10.1016/j.cclet.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683720PMC
September 2017
3 Reads

Mechanism and Reactivity of Rh-Catalyzed Intermolecular [5+1] Cycloaddition of 3-Acyloxy-1,4-Enyne (ACE) and CO: A Computational Study.

Chin Chem Lett 2015 Jun 27;26(6):730-734. Epub 2015 Mar 27.

School of Pharmacy and Department of Chemistry, University of Wisconsin, Madison, WI 53705-2222.

The first theoretical study on the mechanism of [RhCl(CO)]-catalyzed [5 + 1] cycloadditions of 3-acyloxy-1,4-enyne (ACE) and CO has been performed using density functional theory (DFT) calculations. The effect of ester on reactivity of this reaction has been investigated. The computational results have revealed that the preferred catalytic cycle involves the sequential steps of 1,2-acyloxy migration, CO insertion, reductive elimination to form ketene intermediate, 6π-electroncyclization, and aromatization to afford the resorcinol product. Read More

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http://dx.doi.org/10.1016/j.cclet.2015.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852877PMC
June 2015
4 Reads

N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis.

Chin Chem Lett 2004 Jan;15(1):1-4

College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072.

Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH(3)CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via S(N)2' mechanism to give the desired N-alkoxyl pyrrolidines. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748332PMC
January 2004
6 Reads
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