1,748,538 results match your criteria China Ocean Engineering[Journal]


Biocompatibility of Biomaterials for Tissue Regeneration or Replacement.

Biotechnol J 2020 Jul 12:e2000160. Epub 2020 Jul 12.

S. Ramakrishna, Centre for Nanofibers & Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore, 117574, Singapore.

Emerging biomaterials for tissue engineering applications witness a multitude of interaction (both along their interface and internally) with human tissue that also changes over time. Insufficient consideration of these spatial and temporal aspects of biomaterial-tissue interactions often raise biocompatibility concerns. This review focuses on strategies implemented in some of the recently developed biomaterials - particularly for soft and hard tissue regeneration or replacement - to overcome potential foreign body response and ensure effective functioning of the biomaterial. Read More

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http://dx.doi.org/10.1002/biot.202000160DOI Listing

Single-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy.

Cancer Commun (Lond) 2020 Jul 12. Epub 2020 Jul 12.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.

Single-cell RNA sequencing (scRNA-seq) is a novel technology that allows transcriptomic analyses of individual cells. During the past decade, scRNA-seq sensitivity, accuracy, and efficiency have improved due to innovations including more sensitive, automated, and cost-effective single-cell isolation methods with higher throughput as well as ongoing technological development of scRNA-seq protocols. Among the variety of current approaches with distinct features, researchers can choose the most suitable method to carry out their research. Read More

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http://dx.doi.org/10.1002/cac2.12078DOI Listing

Antifungal mechanism of Streptomyces ma. FS-4 on fusarium wilt of banana.

J Appl Microbiol 2020 Jul 12. Epub 2020 Jul 12.

Key Laboratory of Tropical Fruit Biology, Ministry of Agriculture, South Subtropical Crop Research Institute, Chinese Academy of Tropical Agricultural Science, 524091, Zhanjiang, China.

Aim: Research on prevention and cure of banana wilt is important to ensure the healthy development of the banana industry. In this study, antifungal mechanism of Streptomyces ma. FS-4 on fusarium wilt of banana was investigated. Read More

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http://dx.doi.org/10.1111/jam.14784DOI Listing

Response: D-dimer triage for COVID-19.

Acad Emerg Med 2020 Jul 12. Epub 2020 Jul 12.

Providence Health System, Seattle, WA, USA.

We thank Dr Al-Najar and colleagues for their letter(1). Our Research Letter(2) from work completed early April 2020 is intended to rapidly communicate our finding of 93% 28-day survival (95% CI, 92-95%) for a normal D-dimer on admission and 98% survival (95% CI, 96-99%) for a normal D-dimer two days later. Because we reported on 749 patients, those estimates had high precision. Read More

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http://dx.doi.org/10.1111/acem.14084DOI Listing

Pan-genome analysis of Streptococcus suis serotype 2 revealed genomic diversity among strains of different virulence.

Transbound Emerg Dis 2020 Jul 11. Epub 2020 Jul 11.

College of Veterinary Medicine, Nanjing Agricultural University, Key Lab of Animal Bacteriology, Ministry of Agriculture, OIE Reference Lab for Swine Streptococcosis, Nanjing, 210095, China.

Streptococcus suis (SS) is an emerging zoonotic pathogen that causes severe infections in swine and humans. Among the 33 known serotypes, serotype 2 is most frequently associated with infections in pigs and humans. To better understand the virulence characterization of S. Read More

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http://dx.doi.org/10.1111/tbed.13725DOI Listing

High-resolution temporal dynamic transcriptome landscape reveals a GhCAL-mediated flowering regulatory pathway in cotton (Gossypium hirsutum L.).

Plant Biotechnol J 2020 Jul 12. Epub 2020 Jul 12.

College of Agronomy, Northwest A&F University, Yangling, 712100, Shaanxi, People's Republic of China.

The transition from vegetative to reproductive growth is very important for early maturity in cotton. However, the genetic control of this highly dynamic and complex developmental process remains unclear. A high-resolution tissue- and stage-specific transcriptome profile was generated from six developmental stages using 72 samples of two early-maturing and two late-maturing cotton varieties. Read More

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http://dx.doi.org/10.1111/pbi.13449DOI Listing

Icaritin activates Nrf2/Keap1 signaling to protect neuronal cells from oxidative stress.

Chem Biol Drug Des 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, 276004, PR China.

Our earlier study indicated that icaritin (ICT) protected mice from cerebral ischemic injury by inhibiting oxidative stress, and this study aimed to investigate its mechanism using a H O -treated SH-SY5Y cells model. Cell viability was assessed by cell counting kit 8 (CCK-8). Oxidative stress parameters were detected by flow cytometry, and signaling pathways were analyzed by immunoblotting. Read More

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http://dx.doi.org/10.1111/cbdd.13765DOI Listing

Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma.

FEBS Open Bio 2020 Jul 12. Epub 2020 Jul 12.

Center of Clinical Laboratory, First medical center of Chinese, PLA General Hospital, Beijin, 100853, China.

The identification of non-invasive biomarkers for detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long noncoding RNAs (lncRNAs) have been reported to be possible biomarkers for diagnosis and prognosis of cancer. Here, we examined the suitability of the lncRNA LINC00887 as a potential biomarker for RCC, as its expression has been shown to be elevated in RCC tissue versus normal tissue in the Gene Expression Profiling Interactive Analysis (GEPIA) database. Read More

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http://dx.doi.org/10.1002/2211-5463.12930DOI Listing

Does health-related quality of life in Asian informal caregivers differ between early-onset dementia and late-onset dementia?

Psychogeriatrics 2020 Jul 12. Epub 2020 Jul 12.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Aim: Early-onset dementia (EOD) (defined as dementia onset before age 65) presents specific challenges and issues, adding to the negative impact of dementia on the health-related quality of life (HRQOL) of both patients and their caregivers. However, very few published studies have specifically compared the HRQOL of caregivers of people with EOD and late-onset dementia (LOD). This information is critical in allocating and prioritizing scarce health-care resources. Read More

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http://dx.doi.org/10.1111/psyg.12556DOI Listing

IL17RA variations showed no associations with post-bronchiolitis asthma or lung function.

Pediatr Int 2020 Jul 12. Epub 2020 Jul 12.

Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Background: Interleukin-17A (IL-17A) and IL-17F are involved with pathogenesis of asthma and allergy. Interleukin-17 receptor A (IL-17RA), encoded by the IL17RA gene, is a common receptor for IL-17A and IL-17F. The aim of the present study was to evaluate the association of IL17RA gene variations with asthma, allergy and lung function at school age in children prospectively followed-up after hospitalization for bronchiolitis in early infancy. Read More

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http://dx.doi.org/10.1111/ped.14387DOI Listing

Changing epidemiology of chronic kidney disease due to type 2 diabetes mellitus from 1990 to 2017: estimates from GBD 2017.

J Diabetes Investig 2020 Jul 11. Epub 2020 Jul 11.

Department of Nephrology, Kidney Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background: Type 2 diabetes mellitus (T2DM) has been a leading cause of chronic kidney disease (CKD) with a heterogeneous distribution worldwide. Optimal health-care planning requires an understanding how the burden of CKD due to T2DM has changed over time and geographic location, as well as the potential roles of sociodemographic, clinical, and behavioral factors in these changes.

Methods: We used the Global Burden of Disease data from 1990 to 2017 at the global, regional, and national levels to investigate changes in the incidence, death, and disability-adjusted life years (DALYs) of CKD due to T2DM, incorporating both epidemiological research and risk-factor monitoring. Read More

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http://dx.doi.org/10.1111/jdi.13355DOI Listing

Experiences and responses of nursing students as second victims of patient safety incidents in a clinical setting: a mixed methods study.

J Nurs Manag 2020 Jul 12. Epub 2020 Jul 12.

Department of Nursing, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Aim: To investigate the degree of second victim syndrome among nursing students in clinical practice and determine the rehabilitation process.

Background: Empirical evidence suggests that healthcare providers who are considered second victims suffer from various difficulties. Nursing students in a clinical setting could be potential second victims, but few studies have quantitatively investigated the experiences and explored their response processes. Read More

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http://dx.doi.org/10.1111/jonm.13085DOI Listing

R2R3 MYB-dependent auxin signaling regulates trichome formation, and increased trichome density confers spider mite tolerance on tomato.

Plant Biotechnol J 2020 Jul 12. Epub 2020 Jul 12.

Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences, Chongqing University, Chongqing, 400044, China.

Unicellular and multicellular tomato trichomes function as mechanical and chemical barriers against herbivores. Auxin treatment increased the formation of II, V and VI type trichomes in tomato leaves. The auxin response factor gene SlARF4, which was highly expressed in II, V and VI type trichomes, positively regulated the auxin-induced formation of II, V and VI type trichomes in the tomato leaves. Read More

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http://dx.doi.org/10.1111/pbi.13448DOI Listing

An optimality-based model explains seasonal variation in C3 plant photosynthetic capacity.

Glob Chang Biol 2020 Jul 12. Epub 2020 Jul 12.

Climate and Ecosystem Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

The maximum rate of carboxylation (V ) is an essential leaf trait determining the photosynthetic capacity of plants. Existing approaches for estimating V at large scale mainly rely on empirical relationships with proxies such as leaf nitrogen/chlorophyll content or hyperspectral reflectance, or on complicated inverse models from gross primary production or solar-induced fluorescence. A novel mechanistic approach based on the assumption that plants optimize resource investment coordinating with environment and growth has been shown to accurately predict C3 plant V based on mean growing season environmental conditions. Read More

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http://dx.doi.org/10.1111/gcb.15276DOI Listing

BBX28/BBX29-HY5-BBX30/31 form a feedback loop to fine-tune photomorphogenic development.

Plant J 2020 Jul 12. Epub 2020 Jul 12.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, National Center for Soybean Improvement, College of Agriculture,Nanjing Agricultural University, Nanjing, 210095, China.

Light is one of the key environmental cues controlling photomorphogenic development in plants. A group of B-box (BBX) proteins play critical roles in this developmental process through diverse regulatory mechanisms. In this study, we report that BBX29 acts as a negative regulator of light signaling. Read More

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http://dx.doi.org/10.1111/tpj.14929DOI Listing

PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: A meta-analysis.

BJOG 2020 Jul 12. Epub 2020 Jul 12.

Department of Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Up to 70% of the patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down the reccurence.

Objectives: To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer. Read More

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http://dx.doi.org/10.1111/1471-0528.16411DOI Listing

Synaptic organization of cortico-cortical communication in primates.

Eur J Neurosci 2020 Jul 12. Epub 2020 Jul 12.

Complex Systems and Computational Neuroscience Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, Hungary.

In cortical circuitry synaptic communication across areas is based on two types of axon terminals, small and large, with modulatory and driving roles, respectively. In contrast, it is not known whether similar synaptic specializations exist for intra-areal projections. Using anterograde tracing and three-dimensional reconstruction by electron microscopy (3D-EM) we asked if large boutons form synapses in the circuit of somatosensory cortical areas 3b and 1. Read More

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http://dx.doi.org/10.1111/ejn.14905DOI Listing

Enhanced silk yield in transgenic silkworm (Bombyx mori) via ectopic expression of BmGT1-L in the posterior silk gland.

Insect Mol Biol 2020 Jul 12. Epub 2020 Jul 12.

Biological Science Research Center, Southwest University, Chongqing, China.

The silkworm is an economically important insect producing plentiful silk fiber in the silk gland. In this study, we reported a cross-talk between the fat body, silk gland and midgut through glycine-serine biosynthetic pathway in the silkworm. Amino acid sequence and functional domains of glycine transporter gene BmGT1-L were mapped. Read More

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http://dx.doi.org/10.1111/imb.12655DOI Listing

Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Infectious Diseases Clinic, Linyi People's Hospital, Linyi, P.R. China.

Long non-coding RNAs (lncRNAs) have been highlighted as prominent genetic modulators involved in multiple important biological processes of cancer cells, especially in esophageal cancer (EC). We tried to elucidate the potential role of LINC00337 in the progression of EC. Based on TCGA database analysis and Reverse transcription quantitative polymerase chain reaction determination, high expression of LINC00337 and FSCN1 was detected, while miR-145 exhibited a low expression in EC. Read More

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http://dx.doi.org/10.1096/fj.202000470DOI Listing

Relapse-Related Molecular Signature in early stage Lung Adenocarcinomas based on BER, STING pathway and TILs.

Cancer Sci 2020 Jul 12. Epub 2020 Jul 12.

Cancer Center, Daping Hospital & Army Medical Center of PLA, Third Military Medical University(Army Medical University), Chongqing, 400042, China.

Approximately 30% of patients with early stage NSCLC relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I-LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor-infiltrating lymphocytes (TILs) to explore the relationship between protein expression and prognosis. Read More

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http://dx.doi.org/10.1111/cas.14570DOI Listing

The recent challenges of highly contagious COVID-19; causing respiratory infections: symptoms, diagnosis, transmission, possible vaccines, animal models and immunotherapy.

Chem Biol Drug Des 2020 Jul 12. Epub 2020 Jul 12.

Department of medicinal chemistry, National University of Pharmacy, Pushkinska str. 53, Kharkiv, 61002, Ukraine.

COVID-19 is highly contagious pathogenic viral infection initiated from Wuhan seafood wholesale market of China on December 2019 and spread rapidly around the whole world due to onward transmission. This recent outbreak of novel coronavirus (CoV) was believed to be originated from bats and causing respiratory infections such as common cold, dry cough, fever, headache, dyspnea, pneumonia and finally Severe Acute Respiratory Syndrome (SARS) in humans. For this widespread zoonotic virus, human-to-human transmission has resulted in nearly 83 lakh cases in 213 countries and territories with 4,50,686 deaths as on 19th June 2020. Read More

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http://dx.doi.org/10.1111/cbdd.13761DOI Listing

Lessons from the Ebola epidemics and their applications for COVID-19 pandemic response in sub-Saharan Africa.

Dev World Bioeth 2020 Jul 12. Epub 2020 Jul 12.

COVID-19, caused by a novel coronavirus named SARS-CoV-2, was identified in December 2019, in Wuhan, China. It was first confirmed in sub-Saharan Africa in Nigeria on 27 February 2020 and has since spread quickly to all sub-Saharan African countries, causing more than 111,309 confirmed cases and 2,498 deaths as of 03 June 2020. The lessons learned during the recent Ebola virus disease (EVD) outbreaks in some sub-Saharan African countries were expected to shape and influence the region's responses to COVID-19 pandemic. Read More

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http://dx.doi.org/10.1111/dewb.12275DOI Listing

Functional divergence of white genes in Henosepilachna vigintioctopunctata revealed by RNA interference.

Insect Mol Biol 2020 Jul 12. Epub 2020 Jul 12.

Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.

Henosepilachna vigintioctopunctata is a serious pest of Solanaceae and Cucurbitaceae in many Asian countries. RNA interference (RNAi) can effectively reduce transcript abundance in this beetle, offering opportunities to explore the biological function of specific genes. The white gene encodes a half-type ATP-binding cassette transporter that plays an essential role in tryptophan, guanine and uric acid transport across membranes. Read More

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http://dx.doi.org/10.1111/imb.12656DOI Listing

Dietary supplementation with Bacillus mixture modifies the intestinal ecosystem of weaned piglets in an overall beneficial way.

J Appl Microbiol 2020 Jul 11. Epub 2020 Jul 11.

CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China.

Aims: This study was conducted to investigate the effects of dietary supplementation with a mixture of Bacillus, which serves as an alternative of antibiotics on the intestinal ecosystem of weaned piglets.

Methods And Results: We randomly assigned 120 piglets to three groups: a control group (a basal diet), a probiotics group (a basal diet supplemented with 4 × 10 cfu g Bacillus licheniformis-Bacillus. subtilis mixture; BLS mix), and an antibiotics group (a basal diet supplemented with 0. Read More

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http://dx.doi.org/10.1111/jam.14782DOI Listing

Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells.

Oral Dis 2020 Jul 12. Epub 2020 Jul 12.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China.

Objective: There were rarely investigations on the effects and molecular mechanisms of oral squamous cell carcinoma (OSCC) cells when treated with isorhamnetin. This article assesses the anticancer effect of isorhamnetin.

Methods And Materials: OSCC cells were treated with or without isorhamnetin. Read More

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http://dx.doi.org/10.1111/odi.13548DOI Listing

Enolase-phosphatase 1 acts as an oncogenic driver in glioma.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China.

Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in l-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. Read More

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http://dx.doi.org/10.1002/jcp.29926DOI Listing

A rare case of Klippel-Trenaunay syndrome in association with Sturge-Weber syndrome treated by HMME-PDT.

Photodermatol Photoimmunol Photomed 2020 Jul 11. Epub 2020 Jul 11.

West China Hospital of Sichuan University, Department of Dermatovenereology, Chengdu, China.

A 30-year-old male patient presented with red patches since birth, and then turned to purple patches, involving his face, breast, lower extremities, scrotum as well as penis. Additionally, the right lower limb was longer and thicker than the left lower limb. X-ray examination illustrated the left femur and tibia were longer than the opposite ones. Read More

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http://dx.doi.org/10.1111/phpp.12587DOI Listing

Esthetic- and patient-related outcomes following root coverage procedures: A systematic review and network meta-analysis.

J Clin Periodontol 2020 Jul 12. Epub 2020 Jul 12.

European Research Group on Periodontology (ERGOPERIO), Genova, Italy.

Background: Aim of this systematic review (SR) of randomized controlled trials (RCTs) was to evaluate effect of different flap designs and graft materials for root coverage, in term of esthetics, patient satisfaction and self-reported morbidity (post-operative pain/discomfort).

Material And Methods: A comprehensive literature search was performed. A mixed-modeling approach to Network Meta-Analysis was utilized to formulate direct and indirect comparisons among treatments for Root Coverage Esthetic Score (RES), with its individual components, and for subjective patient-reported satisfaction and post-operative pain/discomfort (visual analogue scale (VAS) of 100). Read More

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http://dx.doi.org/10.1111/jcpe.13346DOI Listing

Mission Abort Policy for Systems with Observable States of Standby Components.

Risk Anal 2020 Jul 11. Epub 2020 Jul 11.

Collaborative Autonomic Computing Laboratory, School of Computer Science, University of Electronic Science and Technology of China, Chengdu, China.

For some critical applications, successfully accomplishing the mission or surviving the system through aborting the mission and performing a rescue procedure in the event of certain deterioration condition being satisfied are both pivotal. This has motivated considerable studies on mission abort policies (MAPs) to mitigate the risk of system loss in the past several years, especially for standby systems that use one or multiple standby sparing components to continue the mission when the online component fails, improving the mission success probability. The existing MAPs are mainly based on the number of failed online components ignoring the status of the standby components. Read More

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http://dx.doi.org/10.1111/risa.13532DOI Listing

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.

Hepatology 2020 Jul 12. Epub 2020 Jul 12.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.

To identify the regulatory role of protein phosphatase 2A (PP2A) in the development of liver disease, we generated a mouse model with hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit). Homozygote (HO) mice and matched wild-type (WT) littermates were investigated at 3, 6, 9, 12, 15, and 18 months-of-age, respectively. Pathological examination showed that PP2A Aα deficiency in hepatocytes resulted in progressive liver fibrosis phenotype from 9 months-of-age. Read More

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http://dx.doi.org/10.1002/hep.31457DOI Listing

Susceptibility testing of clinical isolates of Sporothrix globosa in Shandong, China.

Mycoses 2020 Jul 12. Epub 2020 Jul 12.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, China.

Objective: To evaluate the antifungal susceptibility of Sporothrix globosa isolated from Shandong, China and compare the differences of antifungal activity in vitro between yeast and mycelial phase.

Methods: The in vitro sensitivity of mycelium phase and yeast phase of Sporothrix globosa to anidulafungin, micafungin, caspofungin, 5-flucytosine, posaconazole, voriconazole, itraconazole, fluconazole, and amphotericin B was tested by Sensititre™ YeastOne™. The minimum inhibitory concentration (MIC) values of mycelium phase and yeast phase were calculated. Read More

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http://dx.doi.org/10.1111/myc.13141DOI Listing

Water content quantitatively affects metabolic rates over the course of plant ontogeny.

New Phytol 2020 Jul 12. Epub 2020 Jul 12.

State Key Laboratory of Grassland Agro-Ecosystem, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.

Plant metabolism determines the structure and dynamics of ecological systems across many different scales. The metabolic theory of ecology (MTE) quantitatively predicts the scaling of metabolic rate as a function of body size and temperature. However, the role of tissue water content has been neglected even though hydration significantly affects metabolism, and thus ecosystem structure and functioning. Read More

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http://dx.doi.org/10.1111/nph.16808DOI Listing

FoxO1a mediated cadmium-induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cadmium (Cd), a type of heavy metal that accumulates in the body because of smoking, mediates the toxic effect of smoking in many diseases, such as cardiovascular disease, osteoarthritis, and osteoporosis. However, the toxic effect of Cd on intervertebral disc tissues have not been reported. In the current study, we demonstrated that Cd induced the apoptosis of annulus fibrosus (AF) cells, which contributed to intervertebral disc degeneration (IVDD). Read More

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http://dx.doi.org/10.1002/jcp.29895DOI Listing

Completion lymph node dissection in patients with sentinel lymph node positive cutaneous head and neck melanoma.

J Surg Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgical Oncology, Mayo Clinic, Jacksonville, Florida.

Background: Relatively few cutaneous head and neck melanoma (CHNM) patients with were included in the multicenter selective lymphadenectomy trial II (MSLT-II). Our objective was to investigate whether immediate completion lymph node dissection completion of lymph node dissection (CLND) was associated with survival benefit for sentinel lymph node (SLN) positive CHNM using the National Cancer Database.

Methods: SLN positive patients with CHNM from 2012 to 2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/jso.26119DOI Listing

The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions.

Scand J Immunol 2020 Jul 12:e12933. Epub 2020 Jul 12.

Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.

Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Read More

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http://dx.doi.org/10.1111/sji.12933DOI Listing

Nanographene oxides carrying antisense walR RNA regulates the Enterococcus faecalis biofilm formation and its susceptibility to chlorhexidine.

Lett Appl Microbiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.

Enterococcus faecalis (E. faecalis) is the dominant pathogen for persistent periapical periodontitis. The chlorhexidine (CHX) is used as conversional irrigation agents during endodontic root canal therapy. Read More

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http://dx.doi.org/10.1111/lam.13354DOI Listing

Natural variation in the OsbZIP18 promoter contributes to branched-chain amino acid levels in rice.

New Phytol 2020 Jul 11. Epub 2020 Jul 11.

National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, 430070, China.

Branched-chain amino acids (BCAAs) are essential amino acids that must be obtained from the diet for humans and animals, and they play important roles in various aspects of plant growth and development. Although BCAA biosynthetic pathways in higher plants have been uncovered, knowledge of their genetic control is still limited, and no positive regulators have been identified to date. Here, we showed that variation in BCAA levels in rice is attributable to differential transcription of OsbZIP18, a basic leucine zipper (bZIP) transcription factor, due to polymorphisms in its promoter. Read More

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http://dx.doi.org/10.1111/nph.16800DOI Listing

Climate and phylogenetic history structure morphological and architectural trait variation among fine-root orders.

New Phytol 2020 Jul 12. Epub 2020 Jul 12.

Department of Plant and Microbial Biology, University of Minnesota, St. Paul, MN, 55108, USA.

Rationale: Fine roots mediate belowground resource acquisition, yet understanding of how fine-root functional traits vary along environmental gradients, within branching orders, and across phylogenetic scales remains limited.

Methods: Morphological and architectural fine-root traits were measured on individual root orders of 20 oak species (genus Quercus) from divergent climates of origin that were harvested after three growing seasons in a glasshouse. These were then compared with similar measurements obtained from a phylogenetically diverse dataset of woody species from the Fine-Root Ecology Database (FRED). Read More

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http://dx.doi.org/10.1111/nph.16804DOI Listing

A framework to assess the carbon supply-consumption balance in plant roots.

New Phytol 2020 Jul 12. Epub 2020 Jul 12.

Department of Forest Ecology and Management, Swedish University of Agricultural Sciences, Umeå, 90183, Sweden.

Plant uptake and transportation of resources, such as water, nutrients and photosynthates, are crucial for plant growth, and a main driver of ecosystem functioning and community responses to environmental changes (Evert, 2006; Ma et al., 2018; Steidinger et al., 2019). Read More

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http://dx.doi.org/10.1111/nph.16807DOI Listing

MiR-92 overexpression suppresses immune cell function in ovarian cancer via LATS2/YAP1/PD-L1 pathway.

Authors:
S Feng H Sun W Zhu

Clin Transl Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu Province, People's Republic of China.

Purpose: Increasing evidence suggested that microRNA plays an important role in ovarian cancer. In this study, the role of miR-92 in ovarian cancer was investigated.

Methods: In this study, miR-92 expression in clinical sample was evaluated, role of miR-92 was investigated in vitro, and underlying mechanism was investigated using Chip, co-IP, and western blot. Read More

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http://dx.doi.org/10.1007/s12094-020-02439-yDOI Listing

Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant.

J Nephrol 2020 Jul 11. Epub 2020 Jul 11.

Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.

Background: Kidney transplantation offers the best potential for full rehabilitation in patients with end-stage kidney disease who are treated with dialysis. However, due to organ shortage which is a universal phenomenon, most patients need to be maintained on a period of dialysis therapy before the prospect of transplantation. Peritoneal dialysis (PD) could be an ideal form of renal replacement therapy due to its favorable profile toward preservation of residual renal function, patient survival, lower overall burden on cardiovascular morbidity and infection risks. Read More

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http://dx.doi.org/10.1007/s40620-020-00787-0DOI Listing

Long-term results of the edge-to-edge repair for failed mitral valve repair as a bailout option.

Gen Thorac Cardiovasc Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Surgery, Fuwai Hospital, Chinese Academy of Medical Science, No. 167, North Lishi Road, Xicheng District, Beijing, 100037, China.

Objective: We evaluate the long-term clinical and echocardiographic outcomes of edge-to-edge (E2E) repair combined with mitral annuloplasty in our institute with degenerative mitral regurgitation (MR) up to 10 years.

Methods: Twenty-six consecutive patients undergoing E2E mitral repair after failure of other conventional mitral repair technique. There were 16 (61. Read More

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http://dx.doi.org/10.1007/s11748-020-01433-zDOI Listing

Effect of dietary isoleucine on skin mucus barrier and epithelial physical barrier functions of hybrid bagrid catfish Pelteobagrus vachelli × Leiocassis longirostris.

Fish Physiol Biochem 2020 Jul 11. Epub 2020 Jul 11.

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.

The study investigated the effects of dietary isoleucine (Ile) on skin mucus barrier and epithelial physical barrier functions of hybrid bagrid catfish Pelteobagrus vachelli × Leiocassis longirostris. A total of 630 fish (33.11 ± 0. Read More

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http://dx.doi.org/10.1007/s10695-020-00826-4DOI Listing

Comparison of efficacy and safety of urate-lowering therapies for hyperuricemic patients with gout: a meta-analysis of randomized, controlled trials.

Clin Rheumatol 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine, Division of Rheumatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.

Objectives: To assess the efficacy and safety of the commonly used urate-lowering therapies (ULTs): febuxostat, allopurinol, and lesinurad in hyperuricemic patients with gout.

Methods: We included all randomized controlled trials (RCTs) that compared ULTs with placebo or head to head. The primary efficacy endpoint was the proportion of subjects achieving the target serum urate (SU) level at month 6. Read More

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http://dx.doi.org/10.1007/s10067-020-05272-4DOI Listing

Optogenetic Activation of Dopamine Receptor D1 and D2 Neurons in Anterior Cingulate Cortex Differentially Modulates Trigeminal Neuropathic Pain.

Mol Neurobiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA.

Anterior cingulate cortex (ACC) is a critical brain center for chronic pain processing. Dopamine signaling in the brain has been demonstrated to contribute to descending pain modulation. However, the role of ACC dopamine receptors in chronic neuropathic pain remains unclear. Read More

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http://dx.doi.org/10.1007/s12035-020-02020-2DOI Listing

WSL9 Encodes an HNH Endonuclease Domain-Containing Protein that Is Essential for Early Chloroplast Development in Rice.

Rice (N Y) 2020 Jul 11;13(1):45. Epub 2020 Jul 11.

State Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.

Background: The plant chloroplast is essential for photosynthesis and other cellular processes, but an understanding of the biological mechanisms of plant chloroplast development are incomplete.

Results: A new temperature-sensitive white stripe leaf 9(wsl9) rice mutant is described. The mutant develops white stripes during early leaf development, but becomes green after the three-leaf stage under field conditions. Read More

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http://dx.doi.org/10.1186/s12284-020-00407-2DOI Listing

Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer.

Cancer Chemother Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.

Gemcitabine (GEM), as an anti-metabolic nucleoside analog, has been shown to have anticancer effects in various tumors, but its chemotherapy resistance is still an important factor leading to poor prognosis of cancer patient. A large number of studies in recent years have shown that autophagy plays an important role in the chemotherapy sensitivity of many tumors, including pancreatic, non-small cell lung, and bladder cancer. However, whether GEM causes autophagy in gallbladder cancer (GBC) and whether it is related to chemotherapy resistance is unknown. Read More

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http://dx.doi.org/10.1007/s00280-020-04100-5DOI Listing

Repetitive transcranial magnetic stimulation as an alternative therapy for stroke with spasticity: a systematic review and meta-analysis.

J Neurol 2020 Jul 11. Epub 2020 Jul 11.

Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China.

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) can be used to manage post-stroke spasticity, but a meta-analysis of the recent randomized-controlled trials (RCTs) is lacking. Our aim is to perform a meta-analysis of the RCTs that investigated the efficacy of rTMS in patients with post-stroke spasticity. PubMed, Embase, and Cochrane Library databases were searched for eligible papers published up to February 2020. Read More

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http://dx.doi.org/10.1007/s00415-020-10058-4DOI Listing

Clinical outcomes of revision with retrograde intermedullary nailing for failed plating of distal femoral fractures: a retrospective study.

Int Orthop 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopaedics, Traditional Chinese Medicine Hospital, Southwest Medical University, 182# Chunhui Road, Luzhou, 646000, Sichuan, People's Republic of China.

Purpose: To assess the feasibility and effectiveness of retrograde intramedullary nail (RIN) revision surgeries for locking compression plate (LCP) failure in distal femoral fractures.

Methods: This retrospective study included 13 patients who suffered from metalwork failures after they initially underwent open reduction and LCP fixation. In patients who eventually underwent RIN revision from January 2014 to December 2016, range of motion (ROM) and Hospital for Special Surgery (HSS) scores obtained before surgery and at the final follow-up time were analysed. Read More

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http://dx.doi.org/10.1007/s00264-020-04621-xDOI Listing

Clinical characteristics and predictors of permanent stoma in rectal cancer patients underwent anterior resections: the value of preoperative prognostic nutritional index.

Int J Clin Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Essential Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.

Objectives: This study was aimed to investigate the correlation between preoperative prognostic nutritional index (PNI) and permanent stoma (PS) in patients with defunctioning stoma (DS) after anterior resections and, based on it, to reveal the clinical value of PNI on clinical strategies about the selection of stoma location.

Methods: A total of 281 consecutive rectal cancer patients who accepted anterior resection and DS in the National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University from June 2008 to June 2018 were enrolled in this study. Receiver operating characteristic (ROC) curve for PNI was performed to discriminate PS. Read More

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http://dx.doi.org/10.1007/s10147-020-01743-5DOI Listing
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